-- dump date 20140619_014837 -- class Genbank::misc_feature -- table misc_feature_note -- id note 320373000001 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 320373000002 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 320373000003 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 320373000004 Uncharacterized conserved protein [Function unknown]; Region: COG4121 320373000005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320373000006 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 320373000007 IHF dimer interface [polypeptide binding]; other site 320373000008 IHF - DNA interface [nucleotide binding]; other site 320373000009 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 320373000010 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 320373000011 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 320373000012 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 320373000013 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320373000014 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320373000015 catalytic residue [active] 320373000016 type II secretion system protein D; Region: type_II_gspD; TIGR02517 320373000017 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373000018 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373000019 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373000020 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 320373000021 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373000022 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 320373000023 type II secretion system protein E; Region: type_II_gspE; TIGR02533 320373000024 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 320373000025 Walker A motif; other site 320373000026 ATP binding site [chemical binding]; other site 320373000027 Walker B motif; other site 320373000028 type II secretion system protein F; Region: GspF; TIGR02120 320373000029 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373000030 Ceramidase; Region: Ceramidase; pfam05875 320373000031 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373000032 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 320373000033 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 320373000034 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 320373000035 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 320373000036 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 320373000037 Type II transport protein GspH; Region: GspH; pfam12019 320373000038 type II secretion system protein I; Region: gspI; TIGR01707 320373000039 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 320373000040 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 320373000041 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 320373000042 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 320373000043 GspL periplasmic domain; Region: GspL_C; pfam12693 320373000044 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 320373000045 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 320373000046 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373000047 MarR family; Region: MarR_2; cl17246 320373000048 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320373000049 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320373000050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373000051 putative substrate translocation pore; other site 320373000052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373000053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373000054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373000055 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 320373000056 putative dimerization interface [polypeptide binding]; other site 320373000057 LrgA family; Region: LrgA; pfam03788 320373000058 LrgB-like family; Region: LrgB; cl00596 320373000059 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 320373000060 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 320373000061 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 320373000062 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 320373000063 flagellar motor switch protein; Validated; Region: fliN; PRK05698 320373000064 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 320373000065 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 320373000066 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 320373000067 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 320373000068 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 320373000069 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 320373000070 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 320373000071 DNA binding residues [nucleotide binding] 320373000072 putative dimer interface [polypeptide binding]; other site 320373000073 putative metal binding residues [ion binding]; other site 320373000074 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373000075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373000076 S-adenosylmethionine binding site [chemical binding]; other site 320373000077 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 320373000078 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 320373000079 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373000080 membrane-bound complex binding site; other site 320373000081 hinge residues; other site 320373000082 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 320373000083 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320373000084 Walker A/P-loop; other site 320373000085 ATP binding site [chemical binding]; other site 320373000086 Q-loop/lid; other site 320373000087 ABC transporter signature motif; other site 320373000088 Walker B; other site 320373000089 D-loop; other site 320373000090 H-loop/switch region; other site 320373000091 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 320373000092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373000093 dimer interface [polypeptide binding]; other site 320373000094 conserved gate region; other site 320373000095 putative PBP binding loops; other site 320373000096 ABC-ATPase subunit interface; other site 320373000097 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 320373000098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373000099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373000100 dimer interface [polypeptide binding]; other site 320373000101 phosphorylation site [posttranslational modification] 320373000102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373000103 ATP binding site [chemical binding]; other site 320373000104 Mg2+ binding site [ion binding]; other site 320373000105 G-X-G motif; other site 320373000106 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 320373000107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373000108 active site 320373000109 phosphorylation site [posttranslational modification] 320373000110 intermolecular recognition site; other site 320373000111 dimerization interface [polypeptide binding]; other site 320373000112 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373000113 DNA binding site [nucleotide binding] 320373000114 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373000115 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373000116 trimer interface [polypeptide binding]; other site 320373000117 eyelet of channel; other site 320373000118 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 320373000119 DNA methylase; Region: N6_N4_Mtase; pfam01555 320373000120 DNA methylase; Region: N6_N4_Mtase; cl17433 320373000121 Restriction endonuclease [Defense mechanisms]; Region: COG3587 320373000122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320373000123 ATP binding site [chemical binding]; other site 320373000124 putative Mg++ binding site [ion binding]; other site 320373000125 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373000126 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373000127 trimer interface [polypeptide binding]; other site 320373000128 eyelet of channel; other site 320373000129 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320373000130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373000131 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320373000132 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320373000133 Walker A/P-loop; other site 320373000134 ATP binding site [chemical binding]; other site 320373000135 Q-loop/lid; other site 320373000136 ABC transporter signature motif; other site 320373000137 Walker B; other site 320373000138 D-loop; other site 320373000139 H-loop/switch region; other site 320373000140 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320373000141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373000142 Walker A/P-loop; other site 320373000143 ATP binding site [chemical binding]; other site 320373000144 Q-loop/lid; other site 320373000145 ABC transporter signature motif; other site 320373000146 Walker B; other site 320373000147 D-loop; other site 320373000148 H-loop/switch region; other site 320373000149 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320373000150 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320373000151 TM-ABC transporter signature motif; other site 320373000152 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320373000153 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373000154 TM-ABC transporter signature motif; other site 320373000155 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 320373000156 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 320373000157 putative ligand binding site [chemical binding]; other site 320373000158 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320373000159 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320373000160 NAD(P) binding site [chemical binding]; other site 320373000161 catalytic residues [active] 320373000162 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 320373000163 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 320373000164 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320373000165 classical (c) SDRs; Region: SDR_c; cd05233 320373000166 NAD(P) binding site [chemical binding]; other site 320373000167 active site 320373000168 choline dehydrogenase; Validated; Region: PRK02106 320373000169 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 320373000170 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320373000171 Predicted transcriptional regulators [Transcription]; Region: COG1695 320373000172 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 320373000173 Predicted membrane protein [Function unknown]; Region: COG4709 320373000174 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 320373000175 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320373000176 putative di-iron ligands [ion binding]; other site 320373000177 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 320373000178 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 320373000179 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 320373000180 conserved cys residue [active] 320373000181 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373000182 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373000183 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373000184 active site 320373000185 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 320373000186 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320373000187 dimer interface [polypeptide binding]; other site 320373000188 active site 320373000189 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 320373000190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373000191 substrate binding site [chemical binding]; other site 320373000192 oxyanion hole (OAH) forming residues; other site 320373000193 trimer interface [polypeptide binding]; other site 320373000194 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320373000195 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320373000196 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320373000197 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320373000198 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 320373000199 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 320373000200 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373000201 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373000202 DNA binding residues [nucleotide binding] 320373000203 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 320373000204 putative heme binding pocket [chemical binding]; other site 320373000205 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 320373000206 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 320373000207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373000208 ATP binding site [chemical binding]; other site 320373000209 Mg2+ binding site [ion binding]; other site 320373000210 G-X-G motif; other site 320373000211 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 320373000212 anchoring element; other site 320373000213 dimer interface [polypeptide binding]; other site 320373000214 ATP binding site [chemical binding]; other site 320373000215 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 320373000216 active site 320373000217 putative metal-binding site [ion binding]; other site 320373000218 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 320373000219 DNA polymerase III subunit beta; Validated; Region: PRK05643 320373000220 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 320373000221 putative DNA binding surface [nucleotide binding]; other site 320373000222 dimer interface [polypeptide binding]; other site 320373000223 beta-clamp/clamp loader binding surface; other site 320373000224 beta-clamp/translesion DNA polymerase binding surface; other site 320373000225 DnaA N-terminal domain; Region: DnaA_N; pfam11638 320373000226 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 320373000227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373000228 Walker A motif; other site 320373000229 ATP binding site [chemical binding]; other site 320373000230 Walker B motif; other site 320373000231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 320373000232 arginine finger; other site 320373000233 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 320373000234 DnaA box-binding interface [nucleotide binding]; other site 320373000235 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 320373000236 Ribonuclease P; Region: Ribonuclease_P; cl00457 320373000237 hypothetical protein; Validated; Region: PRK00041 320373000238 membrane protein insertase; Provisional; Region: PRK01318 320373000239 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 320373000240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373000241 sequence-specific DNA binding site [nucleotide binding]; other site 320373000242 salt bridge; other site 320373000243 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 320373000244 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 320373000245 trmE is a tRNA modification GTPase; Region: trmE; cd04164 320373000246 G1 box; other site 320373000247 GTP/Mg2+ binding site [chemical binding]; other site 320373000248 Switch I region; other site 320373000249 G2 box; other site 320373000250 Switch II region; other site 320373000251 G3 box; other site 320373000252 G4 box; other site 320373000253 G5 box; other site 320373000254 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 320373000255 integrase; Provisional; Region: PRK09692 320373000256 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 320373000257 active site 320373000258 Int/Topo IB signature motif; other site 320373000259 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 320373000260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 320373000261 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 320373000262 active site 320373000263 metal binding site [ion binding]; metal-binding site 320373000264 interdomain interaction site; other site 320373000265 Domain of unknown function (DUF927); Region: DUF927; pfam06048 320373000266 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 320373000267 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 320373000268 multiple promoter invertase; Provisional; Region: mpi; PRK13413 320373000269 catalytic residues [active] 320373000270 catalytic nucleophile [active] 320373000271 Presynaptic Site I dimer interface [polypeptide binding]; other site 320373000272 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 320373000273 Synaptic Flat tetramer interface [polypeptide binding]; other site 320373000274 Synaptic Site I dimer interface [polypeptide binding]; other site 320373000275 DNA binding site [nucleotide binding] 320373000276 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 320373000277 DNA-binding interface [nucleotide binding]; DNA binding site 320373000278 AAA domain; Region: AAA_13; pfam13166 320373000279 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 320373000280 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 320373000281 transport protein sec23; Provisional; Region: PLN00162 320373000282 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 320373000283 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320373000284 YaeQ protein; Region: YaeQ; pfam07152 320373000285 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 320373000286 dimer interface [polypeptide binding]; other site 320373000287 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373000288 metal binding site [ion binding]; metal-binding site 320373000289 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 320373000290 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 320373000291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373000292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373000293 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 320373000294 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 320373000295 DNA binding site [nucleotide binding] 320373000296 active site 320373000297 AlkA N-terminal domain; Region: AlkA_N; pfam06029 320373000298 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 320373000299 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 320373000300 minor groove reading motif; other site 320373000301 helix-hairpin-helix signature motif; other site 320373000302 substrate binding pocket [chemical binding]; other site 320373000303 active site 320373000304 glutamate--cysteine ligase; Provisional; Region: PRK02107 320373000305 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 320373000306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373000307 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 320373000308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373000309 DNA binding residues [nucleotide binding] 320373000310 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 320373000311 dimer interface [polypeptide binding]; other site 320373000312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373000313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373000314 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373000315 putative effector binding pocket; other site 320373000316 dimerization interface [polypeptide binding]; other site 320373000317 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 320373000318 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320373000319 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320373000320 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 320373000321 active site 320373000322 metal binding site [ion binding]; metal-binding site 320373000323 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 320373000324 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 320373000325 putative active site; other site 320373000326 catalytic triad [active] 320373000327 putative dimer interface [polypeptide binding]; other site 320373000328 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 320373000329 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320373000330 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 320373000331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 320373000332 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 320373000333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373000334 putative PBP binding loops; other site 320373000335 ABC-ATPase subunit interface; other site 320373000336 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 320373000337 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373000338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373000339 Coenzyme A binding pocket [chemical binding]; other site 320373000340 portal vertex protein; Provisional; Region: Q; PHA02536 320373000341 Phage portal protein; Region: Phage_portal; pfam04860 320373000342 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 320373000343 hypothetical protein; Provisional; Region: PRK01184 320373000344 Deoxycytidylate deaminase [Nucleotide transport and metabolism]; Region: ComEB; COG2131 320373000345 active site 320373000346 Zn binding site [ion binding]; other site 320373000347 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320373000348 CoenzymeA binding site [chemical binding]; other site 320373000349 subunit interaction site [polypeptide binding]; other site 320373000350 PHB binding site; other site 320373000351 Patatin-like phospholipase; Region: Patatin; pfam01734 320373000352 active site 320373000353 nucleophile elbow; other site 320373000354 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 320373000355 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 320373000356 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 320373000357 dimerization interface [polypeptide binding]; other site 320373000358 NAD binding site [chemical binding]; other site 320373000359 ligand binding site [chemical binding]; other site 320373000360 catalytic site [active] 320373000361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373000362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373000363 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373000364 putative effector binding pocket; other site 320373000365 dimerization interface [polypeptide binding]; other site 320373000366 DNA topoisomerase III; Validated; Region: PRK08173 320373000367 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 320373000368 active site 320373000369 putative interdomain interaction site [polypeptide binding]; other site 320373000370 putative metal-binding site [ion binding]; other site 320373000371 putative nucleotide binding site [chemical binding]; other site 320373000372 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 320373000373 domain I; other site 320373000374 DNA binding groove [nucleotide binding] 320373000375 phosphate binding site [ion binding]; other site 320373000376 domain II; other site 320373000377 domain III; other site 320373000378 nucleotide binding site [chemical binding]; other site 320373000379 catalytic site [active] 320373000380 domain IV; other site 320373000381 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 320373000382 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 320373000383 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320373000384 catalytic residues [active] 320373000385 DNA protecting protein DprA; Region: dprA; TIGR00732 320373000386 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 320373000387 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 320373000388 active site 320373000389 catalytic residues [active] 320373000390 metal binding site [ion binding]; metal-binding site 320373000391 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 320373000392 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 320373000393 putative active site [active] 320373000394 substrate binding site [chemical binding]; other site 320373000395 putative cosubstrate binding site; other site 320373000396 catalytic site [active] 320373000397 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 320373000398 substrate binding site [chemical binding]; other site 320373000399 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373000400 M48 family peptidase; Provisional; Region: PRK03001 320373000401 16S rRNA methyltransferase B; Provisional; Region: PRK10901 320373000402 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 320373000403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373000404 S-adenosylmethionine binding site [chemical binding]; other site 320373000405 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 320373000406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373000407 dimerization interface [polypeptide binding]; other site 320373000408 PAS domain; Region: PAS; smart00091 320373000409 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 320373000410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373000411 dimer interface [polypeptide binding]; other site 320373000412 phosphorylation site [posttranslational modification] 320373000413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373000414 ATP binding site [chemical binding]; other site 320373000415 Mg2+ binding site [ion binding]; other site 320373000416 G-X-G motif; other site 320373000417 Response regulator receiver domain; Region: Response_reg; pfam00072 320373000418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373000419 active site 320373000420 phosphorylation site [posttranslational modification] 320373000421 intermolecular recognition site; other site 320373000422 dimerization interface [polypeptide binding]; other site 320373000423 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 320373000424 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 320373000425 Ligand Binding Site [chemical binding]; other site 320373000426 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 320373000427 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 320373000428 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 320373000429 active site 320373000430 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 320373000431 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 320373000432 Sel1 repeat; Region: Sel1; cl02723 320373000433 Sel1-like repeats; Region: SEL1; smart00671 320373000434 Sel1-like repeats; Region: SEL1; smart00671 320373000435 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 320373000436 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 320373000437 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320373000438 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320373000439 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 320373000440 rod shape-determining protein MreC; Provisional; Region: PRK13922 320373000441 rod shape-determining protein MreC; Region: MreC; pfam04085 320373000442 rod shape-determining protein MreB; Provisional; Region: PRK13927 320373000443 MreB and similar proteins; Region: MreB_like; cd10225 320373000444 nucleotide binding site [chemical binding]; other site 320373000445 Mg binding site [ion binding]; other site 320373000446 putative protofilament interaction site [polypeptide binding]; other site 320373000447 RodZ interaction site [polypeptide binding]; other site 320373000448 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 320373000449 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 320373000450 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 320373000451 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 320373000452 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 320373000453 GatB domain; Region: GatB_Yqey; smart00845 320373000454 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 320373000455 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 320373000456 putative active site [active] 320373000457 putative catalytic site [active] 320373000458 putative DNA binding site [nucleotide binding]; other site 320373000459 putative phosphate binding site [ion binding]; other site 320373000460 metal binding site A [ion binding]; metal-binding site 320373000461 putative AP binding site [nucleotide binding]; other site 320373000462 putative metal binding site B [ion binding]; other site 320373000463 Transposase domain (DUF772); Region: DUF772; pfam05598 320373000464 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320373000465 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320373000466 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 320373000467 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 320373000468 putative NAD(P) binding site [chemical binding]; other site 320373000469 putative substrate binding site [chemical binding]; other site 320373000470 catalytic Zn binding site [ion binding]; other site 320373000471 structural Zn binding site [ion binding]; other site 320373000472 dimer interface [polypeptide binding]; other site 320373000473 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 320373000474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373000475 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373000476 Peptidase family M48; Region: Peptidase_M48; cl12018 320373000477 muropeptide transporter; Reviewed; Region: ampG; PRK11902 320373000478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373000479 putative substrate translocation pore; other site 320373000480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320373000481 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 320373000482 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 320373000483 division inhibitor protein; Provisional; Region: slmA; PRK09480 320373000484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373000485 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 320373000486 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 320373000487 feedback inhibition sensing region; other site 320373000488 homohexameric interface [polypeptide binding]; other site 320373000489 nucleotide binding site [chemical binding]; other site 320373000490 N-acetyl-L-glutamate binding site [chemical binding]; other site 320373000491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373000492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 320373000493 dimer interface [polypeptide binding]; other site 320373000494 phosphorylation site [posttranslational modification] 320373000495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373000496 ATP binding site [chemical binding]; other site 320373000497 Mg2+ binding site [ion binding]; other site 320373000498 G-X-G motif; other site 320373000499 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 320373000500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373000501 active site 320373000502 phosphorylation site [posttranslational modification] 320373000503 intermolecular recognition site; other site 320373000504 dimerization interface [polypeptide binding]; other site 320373000505 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373000506 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 320373000507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373000508 Walker A motif; other site 320373000509 ATP binding site [chemical binding]; other site 320373000510 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 320373000511 Walker B motif; other site 320373000512 arginine finger; other site 320373000513 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320373000514 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 320373000515 active site 320373000516 HslU subunit interaction site [polypeptide binding]; other site 320373000517 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 320373000518 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 320373000519 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 320373000520 P-loop, Walker A motif; other site 320373000521 Base recognition motif; other site 320373000522 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 320373000523 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 320373000524 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 320373000525 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 320373000526 putative RNA binding site [nucleotide binding]; other site 320373000527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373000528 S-adenosylmethionine binding site [chemical binding]; other site 320373000529 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 320373000530 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373000531 active site 320373000532 DNA binding site [nucleotide binding] 320373000533 Int/Topo IB signature motif; other site 320373000534 Protein of unknown function, DUF484; Region: DUF484; cl17449 320373000535 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 320373000536 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 320373000537 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 320373000538 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 320373000539 putative acyl-acceptor binding pocket; other site 320373000540 S-adenosylmethionine synthetase; Validated; Region: PRK05250 320373000541 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 320373000542 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 320373000543 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 320373000544 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 320373000545 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 320373000546 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320373000547 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 320373000548 active site 320373000549 catalytic tetrad [active] 320373000550 EamA-like transporter family; Region: EamA; pfam00892 320373000551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373000552 putative substrate translocation pore; other site 320373000553 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320373000554 serine/threonine protein kinase; Provisional; Region: PRK11768 320373000555 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 320373000556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373000557 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 320373000558 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 320373000559 NAD(P) binding site [chemical binding]; other site 320373000560 catalytic residues [active] 320373000561 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 320373000562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373000563 active site 320373000564 choline dehydrogenase; Validated; Region: PRK02106 320373000565 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320373000566 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 320373000567 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 320373000568 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 320373000569 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 320373000570 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 320373000571 Walker A motif/ATP binding site; other site 320373000572 Walker B motif; other site 320373000573 flagellar assembly protein H; Validated; Region: fliH; PRK05687 320373000574 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 320373000575 Flagellar assembly protein FliH; Region: FliH; pfam02108 320373000576 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 320373000577 FliG C-terminal domain; Region: FliG_C; pfam01706 320373000578 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 320373000579 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 320373000580 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 320373000581 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 320373000582 flagellar protein FliS; Validated; Region: fliS; PRK05685 320373000583 Flagellar protein FliT; Region: FliT; cl05125 320373000584 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 320373000585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 320373000586 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 320373000587 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 320373000588 XdhC Rossmann domain; Region: XdhC_C; pfam13478 320373000589 amino acid transporter; Region: 2A0306; TIGR00909 320373000590 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 320373000591 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373000592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373000593 active site 320373000594 phosphorylation site [posttranslational modification] 320373000595 intermolecular recognition site; other site 320373000596 dimerization interface [polypeptide binding]; other site 320373000597 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373000598 DNA binding residues [nucleotide binding] 320373000599 dimerization interface [polypeptide binding]; other site 320373000600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 320373000601 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 320373000602 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 320373000603 FAD binding pocket [chemical binding]; other site 320373000604 FAD binding motif [chemical binding]; other site 320373000605 phosphate binding motif [ion binding]; other site 320373000606 beta-alpha-beta structure motif; other site 320373000607 NAD binding pocket [chemical binding]; other site 320373000608 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373000609 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 320373000610 putative catalytic site [active] 320373000611 putative phosphate binding site [ion binding]; other site 320373000612 putative metal binding site [ion binding]; other site 320373000613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373000614 Walker A motif; other site 320373000615 ATP binding site [chemical binding]; other site 320373000616 Walker B motif; other site 320373000617 arginine finger; other site 320373000618 Predicted dehydrogenase [General function prediction only]; Region: COG0579 320373000619 hydroxyglutarate oxidase; Provisional; Region: PRK11728 320373000620 High potential iron-sulfur protein; Region: HIPIP; pfam01355 320373000621 citrate-proton symporter; Provisional; Region: PRK15075 320373000622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373000623 putative substrate translocation pore; other site 320373000624 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 320373000625 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 320373000626 peptide binding site [polypeptide binding]; other site 320373000627 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 320373000628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373000629 dimer interface [polypeptide binding]; other site 320373000630 conserved gate region; other site 320373000631 putative PBP binding loops; other site 320373000632 ABC-ATPase subunit interface; other site 320373000633 dipeptide transporter; Provisional; Region: PRK10913 320373000634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373000635 dimer interface [polypeptide binding]; other site 320373000636 conserved gate region; other site 320373000637 putative PBP binding loops; other site 320373000638 ABC-ATPase subunit interface; other site 320373000639 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 320373000640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373000641 Walker A/P-loop; other site 320373000642 ATP binding site [chemical binding]; other site 320373000643 Q-loop/lid; other site 320373000644 ABC transporter signature motif; other site 320373000645 Walker B; other site 320373000646 D-loop; other site 320373000647 H-loop/switch region; other site 320373000648 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320373000649 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 320373000650 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373000651 Walker A/P-loop; other site 320373000652 ATP binding site [chemical binding]; other site 320373000653 Q-loop/lid; other site 320373000654 ABC transporter signature motif; other site 320373000655 Walker B; other site 320373000656 D-loop; other site 320373000657 H-loop/switch region; other site 320373000658 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 320373000659 TraB family; Region: TraB; pfam01963 320373000660 Predicted membrane protein [Function unknown]; Region: COG3817 320373000661 Protein of unknown function (DUF979); Region: DUF979; pfam06166 320373000662 Protein of unknown function (DUF969); Region: DUF969; pfam06149 320373000663 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 320373000664 putative active site [active] 320373000665 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 320373000666 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 320373000667 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 320373000668 MarR family; Region: MarR_2; cl17246 320373000669 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 320373000670 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 320373000671 lytic murein transglycosylase; Provisional; Region: PRK11619 320373000672 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320373000673 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320373000674 catalytic residue [active] 320373000675 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 320373000676 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 320373000677 putative NAD(P) binding site [chemical binding]; other site 320373000678 active site 320373000679 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320373000680 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 320373000681 putative C-terminal domain interface [polypeptide binding]; other site 320373000682 putative GSH binding site (G-site) [chemical binding]; other site 320373000683 putative dimer interface [polypeptide binding]; other site 320373000684 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 320373000685 putative N-terminal domain interface [polypeptide binding]; other site 320373000686 putative dimer interface [polypeptide binding]; other site 320373000687 putative substrate binding pocket (H-site) [chemical binding]; other site 320373000688 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 320373000689 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 320373000690 active site 320373000691 NTP binding site [chemical binding]; other site 320373000692 metal binding triad [ion binding]; metal-binding site 320373000693 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 320373000694 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 320373000695 Killing trait; Region: RebB; pfam11747 320373000696 FlgN protein; Region: FlgN; pfam05130 320373000697 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 320373000698 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 320373000699 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 320373000700 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 320373000701 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 320373000702 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 320373000703 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320373000704 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320373000705 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 320373000706 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 320373000707 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 320373000708 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 320373000709 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320373000710 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 320373000711 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320373000712 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 320373000713 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320373000714 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 320373000715 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 320373000716 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320373000717 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320373000718 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 320373000719 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 320373000720 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 320373000721 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 320373000722 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 320373000723 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 320373000724 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 320373000725 Flagellar regulator YcgR; Region: YcgR; pfam07317 320373000726 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 320373000727 PilZ domain; Region: PilZ; pfam07238 320373000728 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 320373000729 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320373000730 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 320373000731 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 320373000732 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 320373000733 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320373000734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373000735 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320373000736 dimerization interface [polypeptide binding]; other site 320373000737 substrate binding pocket [chemical binding]; other site 320373000738 Chromate transporter; Region: Chromate_transp; pfam02417 320373000739 Chromate transporter; Region: Chromate_transp; pfam02417 320373000740 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 320373000741 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 320373000742 PhnA protein; Region: PhnA; pfam03831 320373000743 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 320373000744 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373000745 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373000746 trimer interface [polypeptide binding]; other site 320373000747 eyelet of channel; other site 320373000748 putative membrane protein; Region: HpnL; TIGR03476 320373000749 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 320373000750 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 320373000751 ligand binding site; other site 320373000752 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 320373000753 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 320373000754 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 320373000755 glutathione reductase; Validated; Region: PRK06116 320373000756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373000757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373000758 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320373000759 argininosuccinate synthase; Validated; Region: PRK05370 320373000760 argininosuccinate synthase; Provisional; Region: PRK13820 320373000761 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 320373000762 metal-binding site [ion binding] 320373000763 YHS domain; Region: YHS; pfam04945 320373000764 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 320373000765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320373000766 Soluble P-type ATPase [General function prediction only]; Region: COG4087 320373000767 LemA family; Region: LemA; pfam04011 320373000768 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 320373000769 Repair protein; Region: Repair_PSII; pfam04536 320373000770 Repair protein; Region: Repair_PSII; pfam04536 320373000771 HlyD family secretion protein; Region: HlyD_2; pfam12700 320373000772 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373000773 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 320373000774 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 320373000775 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 320373000776 Avidin family; Region: Avidin; pfam01382 320373000777 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 320373000778 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 320373000779 glutaminase active site [active] 320373000780 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 320373000781 dimer interface [polypeptide binding]; other site 320373000782 active site 320373000783 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 320373000784 dimer interface [polypeptide binding]; other site 320373000785 active site 320373000786 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 320373000787 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 320373000788 Substrate binding site; other site 320373000789 Mg++ binding site; other site 320373000790 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 320373000791 active site 320373000792 substrate binding site [chemical binding]; other site 320373000793 CoA binding site [chemical binding]; other site 320373000794 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 320373000795 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 320373000796 Ligand Binding Site [chemical binding]; other site 320373000797 Dihydroneopterin aldolase; Region: FolB; smart00905 320373000798 active site 320373000799 short chain dehydrogenase; Provisional; Region: PRK09134 320373000800 Uncharacterized conserved protein [Function unknown]; Region: COG1565 320373000801 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 320373000802 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 320373000803 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320373000804 putative substrate binding site [chemical binding]; other site 320373000805 putative ATP binding site [chemical binding]; other site 320373000806 dimerization interface [polypeptide binding]; other site 320373000807 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 320373000808 putative active cleft [active] 320373000809 Transcriptional regulators [Transcription]; Region: PurR; COG1609 320373000810 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 320373000811 DNA binding site [nucleotide binding] 320373000812 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 320373000813 ligand binding site [chemical binding]; other site 320373000814 dimerization interface [polypeptide binding]; other site 320373000815 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320373000816 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373000817 dimer interface [polypeptide binding]; other site 320373000818 putative CheW interface [polypeptide binding]; other site 320373000819 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 320373000820 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 320373000821 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373000822 trimer interface [polypeptide binding]; other site 320373000823 eyelet of channel; other site 320373000824 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373000825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373000826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373000827 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373000828 putative effector binding pocket; other site 320373000829 dimerization interface [polypeptide binding]; other site 320373000830 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 320373000831 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 320373000832 FMN binding site [chemical binding]; other site 320373000833 substrate binding site [chemical binding]; other site 320373000834 putative catalytic residue [active] 320373000835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373000836 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373000837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373000838 dimerization interface [polypeptide binding]; other site 320373000839 putative DNA binding site [nucleotide binding]; other site 320373000840 putative Zn2+ binding site [ion binding]; other site 320373000841 AsnC family; Region: AsnC_trans_reg; pfam01037 320373000842 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320373000843 EamA-like transporter family; Region: EamA; pfam00892 320373000844 EamA-like transporter family; Region: EamA; pfam00892 320373000845 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 320373000846 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 320373000847 putative deacylase active site [active] 320373000848 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 320373000849 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 320373000850 active site 320373000851 catalytic residues [active] 320373000852 metal binding site [ion binding]; metal-binding site 320373000853 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 320373000854 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 320373000855 putative ligand binding site [chemical binding]; other site 320373000856 NAD binding site [chemical binding]; other site 320373000857 dimerization interface [polypeptide binding]; other site 320373000858 catalytic site [active] 320373000859 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 320373000860 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373000861 putative metal binding site [ion binding]; other site 320373000862 Serine hydrolase; Region: Ser_hydrolase; pfam06821 320373000863 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320373000864 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679 320373000865 nudix motif; other site 320373000866 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 320373000867 Phosphoesterase family; Region: Phosphoesterase; pfam04185 320373000868 Domain of unknown function (DUF756); Region: DUF756; pfam05506 320373000869 Domain of unknown function (DUF756); Region: DUF756; pfam05506 320373000870 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373000871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373000872 putative DNA binding site [nucleotide binding]; other site 320373000873 putative Zn2+ binding site [ion binding]; other site 320373000874 AsnC family; Region: AsnC_trans_reg; pfam01037 320373000875 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 320373000876 Predicted membrane protein [Function unknown]; Region: COG4541 320373000877 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320373000878 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 320373000879 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 320373000880 dimer interface [polypeptide binding]; other site 320373000881 active site 320373000882 catalytic residue [active] 320373000883 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 320373000884 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 320373000885 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 320373000886 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 320373000887 Inward rectifier potassium channel; Region: IRK; pfam01007 320373000888 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 320373000889 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 320373000890 dimer interface [polypeptide binding]; other site 320373000891 PYR/PP interface [polypeptide binding]; other site 320373000892 TPP binding site [chemical binding]; other site 320373000893 substrate binding site [chemical binding]; other site 320373000894 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 320373000895 TPP-binding site [chemical binding]; other site 320373000896 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 320373000897 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 320373000898 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373000899 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 320373000900 dimer interface [polypeptide binding]; other site 320373000901 Alkaline phosphatase homologues; Region: alkPPc; smart00098 320373000902 active site 320373000903 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 320373000904 Alkaline phosphatase homologues; Region: alkPPc; smart00098 320373000905 active site 320373000906 dimer interface [polypeptide binding]; other site 320373000907 CutC family; Region: CutC; cl01218 320373000908 biotin synthase; Region: bioB; TIGR00433 320373000909 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373000910 FeS/SAM binding site; other site 320373000911 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 320373000912 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 320373000913 AAA domain; Region: AAA_26; pfam13500 320373000914 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 320373000915 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 320373000916 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373000917 catalytic residue [active] 320373000918 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 320373000919 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373000920 inhibitor-cofactor binding pocket; inhibition site 320373000921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373000922 catalytic residue [active] 320373000923 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 320373000924 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 320373000925 hypothetical protein; Provisional; Region: PRK01842 320373000926 short chain dehydrogenase; Provisional; Region: PRK06953 320373000927 NAD(P) binding site [chemical binding]; other site 320373000928 active site 320373000929 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 320373000930 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320373000931 dimer interface [polypeptide binding]; other site 320373000932 active site 320373000933 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 320373000934 active site clefts [active] 320373000935 zinc binding site [ion binding]; other site 320373000936 dimer interface [polypeptide binding]; other site 320373000937 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 320373000938 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 320373000939 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 320373000940 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 320373000941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373000942 Walker A/P-loop; other site 320373000943 ATP binding site [chemical binding]; other site 320373000944 Q-loop/lid; other site 320373000945 ABC transporter signature motif; other site 320373000946 Walker B; other site 320373000947 D-loop; other site 320373000948 H-loop/switch region; other site 320373000949 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320373000950 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 320373000951 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 320373000952 peptide binding site [polypeptide binding]; other site 320373000953 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320373000954 active site 320373000955 MarR family; Region: MarR_2; cl17246 320373000956 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320373000957 short chain dehydrogenase; Validated; Region: PRK08264 320373000958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373000959 NAD(P) binding site [chemical binding]; other site 320373000960 active site 320373000961 short chain dehydrogenase; Provisional; Region: PRK07024 320373000962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373000963 NAD(P) binding site [chemical binding]; other site 320373000964 active site 320373000965 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 320373000966 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 320373000967 catalytic residues [active] 320373000968 hinge region; other site 320373000969 alpha helical domain; other site 320373000970 Sporulation related domain; Region: SPOR; pfam05036 320373000971 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 320373000972 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 320373000973 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 320373000974 active site 320373000975 HIGH motif; other site 320373000976 KMSK motif region; other site 320373000977 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 320373000978 tRNA binding surface [nucleotide binding]; other site 320373000979 anticodon binding site; other site 320373000980 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 320373000981 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 320373000982 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 320373000983 substrate binding pocket [chemical binding]; other site 320373000984 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 320373000985 B12 binding site [chemical binding]; other site 320373000986 cobalt ligand [ion binding]; other site 320373000987 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 320373000988 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 320373000989 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 320373000990 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 320373000991 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 320373000992 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320373000993 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373000994 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 320373000995 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 320373000996 enoyl-CoA hydratase; Provisional; Region: PRK07657 320373000997 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373000998 substrate binding site [chemical binding]; other site 320373000999 oxyanion hole (OAH) forming residues; other site 320373001000 trimer interface [polypeptide binding]; other site 320373001001 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 320373001002 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 320373001003 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 320373001004 active site 320373001005 nucleophile elbow; other site 320373001006 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 320373001007 dinuclear metal binding motif [ion binding]; other site 320373001008 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 320373001009 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 320373001010 active site 320373001011 HIGH motif; other site 320373001012 nucleotide binding site [chemical binding]; other site 320373001013 pantothenate kinase; Reviewed; Region: PRK13328 320373001014 biotin--protein ligase; Provisional; Region: PRK06955 320373001015 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 320373001016 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 320373001017 Sel1-like repeats; Region: SEL1; smart00671 320373001018 Sel1-like repeats; Region: SEL1; smart00671 320373001019 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 320373001020 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 320373001021 active site 320373001022 metal binding site [ion binding]; metal-binding site 320373001023 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 320373001024 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 320373001025 Permease; Region: Permease; pfam02405 320373001026 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 320373001027 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 320373001028 Walker A/P-loop; other site 320373001029 ATP binding site [chemical binding]; other site 320373001030 Q-loop/lid; other site 320373001031 ABC transporter signature motif; other site 320373001032 Walker B; other site 320373001033 D-loop; other site 320373001034 H-loop/switch region; other site 320373001035 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 320373001036 mce related protein; Region: MCE; pfam02470 320373001037 Protein of unknown function (DUF330); Region: DUF330; pfam03886 320373001038 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 320373001039 dimer interface [polypeptide binding]; other site 320373001040 [2Fe-2S] cluster binding site [ion binding]; other site 320373001041 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 320373001042 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 320373001043 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320373001044 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 320373001045 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 320373001046 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 320373001047 homodimer interface [polypeptide binding]; other site 320373001048 substrate-cofactor binding pocket; other site 320373001049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373001050 catalytic residue [active] 320373001051 hypothetical protein; Provisional; Region: PRK02047 320373001052 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320373001053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373001054 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320373001055 dimerization interface [polypeptide binding]; other site 320373001056 substrate binding pocket [chemical binding]; other site 320373001057 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 320373001058 lipoate-protein ligase B; Provisional; Region: PRK14343 320373001059 lipoyl synthase; Provisional; Region: PRK05481 320373001060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373001061 FeS/SAM binding site; other site 320373001062 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320373001063 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 320373001064 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 320373001065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373001066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373001067 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373001068 putative effector binding pocket; other site 320373001069 dimerization interface [polypeptide binding]; other site 320373001070 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 320373001071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373001072 substrate binding site [chemical binding]; other site 320373001073 oxyanion hole (OAH) forming residues; other site 320373001074 trimer interface [polypeptide binding]; other site 320373001075 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320373001076 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320373001077 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320373001078 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 320373001079 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373001080 active site 320373001081 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 320373001082 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 320373001083 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 320373001084 active site 320373001085 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320373001086 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320373001087 Protein of unknown function, DUF485; Region: DUF485; pfam04341 320373001088 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 320373001089 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 320373001090 Na binding site [ion binding]; other site 320373001091 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 320373001092 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 320373001093 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 320373001094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373001095 dimer interface [polypeptide binding]; other site 320373001096 phosphorylation site [posttranslational modification] 320373001097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373001098 ATP binding site [chemical binding]; other site 320373001099 Mg2+ binding site [ion binding]; other site 320373001100 G-X-G motif; other site 320373001101 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320373001102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373001103 active site 320373001104 phosphorylation site [posttranslational modification] 320373001105 intermolecular recognition site; other site 320373001106 dimerization interface [polypeptide binding]; other site 320373001107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373001108 Walker A motif; other site 320373001109 ATP binding site [chemical binding]; other site 320373001110 Walker B motif; other site 320373001111 arginine finger; other site 320373001112 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373001113 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 320373001114 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320373001115 catalytic residues [active] 320373001116 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 320373001117 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 320373001118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373001119 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 320373001120 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 320373001121 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 320373001122 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 320373001123 Membrane fusogenic activity; Region: BMFP; pfam04380 320373001124 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 320373001125 Nitrogen regulatory protein P-II; Region: P-II; smart00938 320373001126 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 320373001127 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 320373001128 Glutamate-cysteine ligase; Region: GshA; pfam08886 320373001129 glutathione synthetase; Provisional; Region: PRK05246 320373001130 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 320373001131 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 320373001132 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 320373001133 active pocket/dimerization site; other site 320373001134 active site 320373001135 phosphorylation site [posttranslational modification] 320373001136 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 320373001137 dimerization domain swap beta strand [polypeptide binding]; other site 320373001138 regulatory protein interface [polypeptide binding]; other site 320373001139 active site 320373001140 regulatory phosphorylation site [posttranslational modification]; other site 320373001141 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 320373001142 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 320373001143 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 320373001144 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 320373001145 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 320373001146 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 320373001147 ATP binding site [chemical binding]; other site 320373001148 substrate interface [chemical binding]; other site 320373001149 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 320373001150 C-terminal peptidase (prc); Region: prc; TIGR00225 320373001151 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 320373001152 protein binding site [polypeptide binding]; other site 320373001153 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 320373001154 Catalytic dyad [active] 320373001155 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320373001156 catalytic core [active] 320373001157 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320373001158 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 320373001159 active site residue [active] 320373001160 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 320373001161 GSH binding site [chemical binding]; other site 320373001162 catalytic residues [active] 320373001163 preprotein translocase subunit SecB; Validated; Region: PRK05751 320373001164 SecA binding site; other site 320373001165 Preprotein binding site; other site 320373001166 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 320373001167 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 320373001168 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 320373001169 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 320373001170 putative ADP-ribose binding site [chemical binding]; other site 320373001171 putative active site [active] 320373001172 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 320373001173 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 320373001174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373001175 active site 320373001176 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 320373001177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373001178 S-adenosylmethionine binding site [chemical binding]; other site 320373001179 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 320373001180 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 320373001181 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 320373001182 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320373001183 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373001184 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 320373001185 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 320373001186 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373001187 ligand binding site [chemical binding]; other site 320373001188 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 320373001189 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 320373001190 Subunit I/III interface [polypeptide binding]; other site 320373001191 D-pathway; other site 320373001192 Subunit I/VIIc interface [polypeptide binding]; other site 320373001193 Subunit I/IV interface [polypeptide binding]; other site 320373001194 Subunit I/II interface [polypeptide binding]; other site 320373001195 Low-spin heme (heme a) binding site [chemical binding]; other site 320373001196 Subunit I/VIIa interface [polypeptide binding]; other site 320373001197 Subunit I/VIa interface [polypeptide binding]; other site 320373001198 Dimer interface; other site 320373001199 Putative water exit pathway; other site 320373001200 Binuclear center (heme a3/CuB) [ion binding]; other site 320373001201 K-pathway; other site 320373001202 Subunit I/Vb interface [polypeptide binding]; other site 320373001203 Putative proton exit pathway; other site 320373001204 Subunit I/VIb interface; other site 320373001205 Subunit I/VIc interface [polypeptide binding]; other site 320373001206 Electron transfer pathway; other site 320373001207 Subunit I/VIIIb interface [polypeptide binding]; other site 320373001208 Subunit I/VIIb interface [polypeptide binding]; other site 320373001209 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 320373001210 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 320373001211 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 320373001212 Subunit III/VIIa interface [polypeptide binding]; other site 320373001213 Phospholipid binding site [chemical binding]; other site 320373001214 Subunit I/III interface [polypeptide binding]; other site 320373001215 Subunit III/VIb interface [polypeptide binding]; other site 320373001216 Subunit III/VIa interface; other site 320373001217 Subunit III/Vb interface [polypeptide binding]; other site 320373001218 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 320373001219 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 320373001220 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 320373001221 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 320373001222 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 320373001223 UbiA prenyltransferase family; Region: UbiA; pfam01040 320373001224 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 320373001225 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320373001226 Cu(I) binding site [ion binding]; other site 320373001227 YCII-related domain; Region: YCII; cl00999 320373001228 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 320373001229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 320373001230 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320373001231 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373001232 dimer interface [polypeptide binding]; other site 320373001233 putative CheW interface [polypeptide binding]; other site 320373001234 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 320373001235 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 320373001236 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 320373001237 zinc binding site [ion binding]; other site 320373001238 putative ligand binding site [chemical binding]; other site 320373001239 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373001240 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 320373001241 TM-ABC transporter signature motif; other site 320373001242 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 320373001243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373001244 Walker A/P-loop; other site 320373001245 ATP binding site [chemical binding]; other site 320373001246 Q-loop/lid; other site 320373001247 ABC transporter signature motif; other site 320373001248 Walker B; other site 320373001249 D-loop; other site 320373001250 H-loop/switch region; other site 320373001251 DNA Polymerase Y-family; Region: PolY_like; cd03468 320373001252 active site 320373001253 DNA binding site [nucleotide binding] 320373001254 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 320373001255 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 320373001256 putative active site [active] 320373001257 putative PHP Thumb interface [polypeptide binding]; other site 320373001258 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 320373001259 generic binding surface II; other site 320373001260 generic binding surface I; other site 320373001261 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 320373001262 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320373001263 putative di-iron ligands [ion binding]; other site 320373001264 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 320373001265 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 320373001266 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373001267 inhibitor-cofactor binding pocket; inhibition site 320373001268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373001269 catalytic residue [active] 320373001270 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320373001271 ABC-2 type transporter; Region: ABC2_membrane; cl17235 320373001272 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 320373001273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373001274 Walker A/P-loop; other site 320373001275 ATP binding site [chemical binding]; other site 320373001276 Q-loop/lid; other site 320373001277 ABC transporter signature motif; other site 320373001278 Walker B; other site 320373001279 D-loop; other site 320373001280 H-loop/switch region; other site 320373001281 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320373001282 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373001283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373001284 S-adenosylmethionine binding site [chemical binding]; other site 320373001285 Citrate synthase; Region: Citrate_synt; pfam00285 320373001286 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 320373001287 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 320373001288 citrylCoA binding site [chemical binding]; other site 320373001289 oxalacetate binding site [chemical binding]; other site 320373001290 coenzyme A binding site [chemical binding]; other site 320373001291 catalytic triad [active] 320373001292 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 320373001293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373001294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373001295 active site 320373001296 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 320373001297 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320373001298 active site 320373001299 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 320373001300 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373001301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373001302 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373001303 acyl-activating enzyme (AAE) consensus motif; other site 320373001304 acyl-activating enzyme (AAE) consensus motif; other site 320373001305 AMP binding site [chemical binding]; other site 320373001306 active site 320373001307 CoA binding site [chemical binding]; other site 320373001308 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 320373001309 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 320373001310 dimer interface [polypeptide binding]; other site 320373001311 active site 320373001312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320373001313 catalytic residues [active] 320373001314 substrate binding site [chemical binding]; other site 320373001315 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320373001316 active site 320373001317 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 320373001318 dinuclear metal binding motif [ion binding]; other site 320373001319 Phosphopantetheine attachment site; Region: PP-binding; cl09936 320373001320 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 320373001321 acyl-CoA synthetase; Validated; Region: PRK09192 320373001322 acyl-activating enzyme (AAE) consensus motif; other site 320373001323 active site 320373001324 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 320373001325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373001326 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 320373001327 dimerization interface [polypeptide binding]; other site 320373001328 substrate binding pocket [chemical binding]; other site 320373001329 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 320373001330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373001331 DNA-binding site [nucleotide binding]; DNA binding site 320373001332 UTRA domain; Region: UTRA; pfam07702 320373001333 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 320373001334 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 320373001335 active site 320373001336 dimer interface [polypeptide binding]; other site 320373001337 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 320373001338 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 320373001339 dimer interface [polypeptide binding]; other site 320373001340 active site 320373001341 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 320373001342 dimer interface [polypeptide binding]; other site 320373001343 active site 320373001344 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 320373001345 HPr interaction site; other site 320373001346 glycerol kinase (GK) interaction site [polypeptide binding]; other site 320373001347 active site 320373001348 phosphorylation site [posttranslational modification] 320373001349 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 320373001350 dimerization domain swap beta strand [polypeptide binding]; other site 320373001351 regulatory protein interface [polypeptide binding]; other site 320373001352 active site 320373001353 regulatory phosphorylation site [posttranslational modification]; other site 320373001354 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 320373001355 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 320373001356 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 320373001357 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 320373001358 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 320373001359 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 320373001360 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 320373001361 active site turn [active] 320373001362 phosphorylation site [posttranslational modification] 320373001363 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 320373001364 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 320373001365 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 320373001366 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 320373001367 active site 320373001368 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 320373001369 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 320373001370 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 320373001371 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 320373001372 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 320373001373 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 320373001374 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 320373001375 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373001376 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373001377 DNA binding residues [nucleotide binding] 320373001378 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 320373001379 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 320373001380 SnoaL-like domain; Region: SnoaL_3; pfam13474 320373001381 2-isopropylmalate synthase; Validated; Region: PRK03739 320373001382 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 320373001383 active site 320373001384 catalytic residues [active] 320373001385 metal binding site [ion binding]; metal-binding site 320373001386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373001387 Coenzyme A binding pocket [chemical binding]; other site 320373001388 glycosyl transferase family protein; Provisional; Region: PRK08136 320373001389 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 320373001390 Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; smart00926 320373001391 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 320373001392 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 320373001393 molybdopterin cofactor binding site; other site 320373001394 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 320373001395 molybdopterin cofactor binding site; other site 320373001396 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 320373001397 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 320373001398 [2Fe-2S] cluster binding site [ion binding]; other site 320373001399 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 320373001400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373001401 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 320373001402 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 320373001403 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320373001404 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320373001405 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 320373001406 C-terminal domain interface [polypeptide binding]; other site 320373001407 GSH binding site (G-site) [chemical binding]; other site 320373001408 putative dimer interface [polypeptide binding]; other site 320373001409 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 320373001410 dimer interface [polypeptide binding]; other site 320373001411 N-terminal domain interface [polypeptide binding]; other site 320373001412 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 320373001413 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 320373001414 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 320373001415 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 320373001416 P loop; other site 320373001417 GTP binding site [chemical binding]; other site 320373001418 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 320373001419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373001420 S-adenosylmethionine binding site [chemical binding]; other site 320373001421 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 320373001422 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 320373001423 active site 320373001424 (T/H)XGH motif; other site 320373001425 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 320373001426 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 320373001427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373001428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373001429 homodimer interface [polypeptide binding]; other site 320373001430 catalytic residue [active] 320373001431 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 320373001432 putative active site [active] 320373001433 catalytic residue [active] 320373001434 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 320373001435 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 320373001436 5S rRNA interface [nucleotide binding]; other site 320373001437 CTC domain interface [polypeptide binding]; other site 320373001438 L16 interface [polypeptide binding]; other site 320373001439 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 320373001440 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 320373001441 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373001442 active site 320373001443 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 320373001444 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 320373001445 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 320373001446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 320373001447 binding surface 320373001448 TPR motif; other site 320373001449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373001450 binding surface 320373001451 TPR motif; other site 320373001452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373001453 binding surface 320373001454 TPR motif; other site 320373001455 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 320373001456 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 320373001457 DNA binding site [nucleotide binding] 320373001458 catalytic residue [active] 320373001459 H2TH interface [polypeptide binding]; other site 320373001460 putative catalytic residues [active] 320373001461 turnover-facilitating residue; other site 320373001462 intercalation triad [nucleotide binding]; other site 320373001463 8OG recognition residue [nucleotide binding]; other site 320373001464 putative reading head residues; other site 320373001465 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 320373001466 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 320373001467 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 320373001468 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 320373001469 minor groove reading motif; other site 320373001470 helix-hairpin-helix signature motif; other site 320373001471 active site 320373001472 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 320373001473 DNA binding and oxoG recognition site [nucleotide binding] 320373001474 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 320373001475 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 320373001476 AAA domain; Region: AAA_18; pfam13238 320373001477 HPr kinase/phosphorylase; Provisional; Region: PRK05428 320373001478 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 320373001479 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 320373001480 Hpr binding site; other site 320373001481 active site 320373001482 homohexamer subunit interaction site [polypeptide binding]; other site 320373001483 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 320373001484 active site 320373001485 phosphorylation site [posttranslational modification] 320373001486 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 320373001487 30S subunit binding site; other site 320373001488 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 320373001489 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 320373001490 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 320373001491 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 320373001492 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 320373001493 Walker A/P-loop; other site 320373001494 ATP binding site [chemical binding]; other site 320373001495 Q-loop/lid; other site 320373001496 ABC transporter signature motif; other site 320373001497 Walker B; other site 320373001498 D-loop; other site 320373001499 H-loop/switch region; other site 320373001500 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 320373001501 OstA-like protein; Region: OstA; pfam03968 320373001502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 320373001503 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 320373001504 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 320373001505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373001506 active site 320373001507 motif I; other site 320373001508 motif II; other site 320373001509 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 320373001510 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 320373001511 putative active site [active] 320373001512 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 320373001513 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 320373001514 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 320373001515 TrkA-N domain; Region: TrkA_N; pfam02254 320373001516 TrkA-C domain; Region: TrkA_C; pfam02080 320373001517 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373001518 active site 320373001519 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373001520 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 320373001521 nudix motif; other site 320373001522 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 320373001523 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 320373001524 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 320373001525 putative active site [active] 320373001526 putative substrate binding site [chemical binding]; other site 320373001527 putative cosubstrate binding site; other site 320373001528 catalytic site [active] 320373001529 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 320373001530 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 320373001531 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 320373001532 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 320373001533 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 320373001534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373001535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373001536 putative substrate translocation pore; other site 320373001537 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 320373001538 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 320373001539 dimer interface [polypeptide binding]; other site 320373001540 ssDNA binding site [nucleotide binding]; other site 320373001541 tetramer (dimer of dimers) interface [polypeptide binding]; other site 320373001542 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 320373001543 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373001544 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 320373001545 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 320373001546 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 320373001547 Family description; Region: VCBS; pfam13517 320373001548 Family description; Region: VCBS; pfam13517 320373001549 Family description; Region: VCBS; pfam13517 320373001550 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 320373001551 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 320373001552 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 320373001553 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 320373001554 Tetratricopeptide repeat; Region: TPR_12; pfam13424 320373001555 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 320373001556 phosphopeptide binding site; other site 320373001557 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 320373001558 active site 320373001559 ATP binding site [chemical binding]; other site 320373001560 substrate binding site [chemical binding]; other site 320373001561 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 320373001562 activation loop (A-loop); other site 320373001563 cyclase homology domain; Region: CHD; cd07302 320373001564 dimer interface [polypeptide binding]; other site 320373001565 nucleotidyl binding site; other site 320373001566 metal binding site [ion binding]; metal-binding site 320373001567 AAA ATPase domain; Region: AAA_16; pfam13191 320373001568 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 320373001569 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 320373001570 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 320373001571 YcaO-like family; Region: YcaO; pfam02624 320373001572 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 320373001573 aldolase II superfamily protein; Provisional; Region: PRK07044 320373001574 intersubunit interface [polypeptide binding]; other site 320373001575 active site 320373001576 Zn2+ binding site [ion binding]; other site 320373001577 PAS domain; Region: PAS; smart00091 320373001578 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320373001579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373001580 metal binding site [ion binding]; metal-binding site 320373001581 active site 320373001582 I-site; other site 320373001583 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373001584 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 320373001585 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 320373001586 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373001587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373001588 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 320373001589 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 320373001590 Substrate binding site; other site 320373001591 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 320373001592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373001593 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373001594 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 320373001595 putative ADP-binding pocket [chemical binding]; other site 320373001596 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 320373001597 active site 320373001598 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320373001599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373001600 Walker A motif; other site 320373001601 ATP binding site [chemical binding]; other site 320373001602 Walker B motif; other site 320373001603 arginine finger; other site 320373001604 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 320373001605 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 320373001606 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 320373001607 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 320373001608 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 320373001609 dimer interface [polypeptide binding]; other site 320373001610 motif 1; other site 320373001611 active site 320373001612 motif 2; other site 320373001613 motif 3; other site 320373001614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373001615 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373001616 active site 320373001617 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373001618 active site 320373001619 acyl carrier protein; Provisional; Region: PRK07081 320373001620 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320373001621 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320373001622 ligand binding site [chemical binding]; other site 320373001623 flexible hinge region; other site 320373001624 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 320373001625 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320373001626 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 320373001627 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 320373001628 non-specific DNA interactions [nucleotide binding]; other site 320373001629 DNA binding site [nucleotide binding] 320373001630 sequence specific DNA binding site [nucleotide binding]; other site 320373001631 putative cAMP binding site [chemical binding]; other site 320373001632 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 320373001633 Bacterial sugar transferase; Region: Bac_transf; pfam02397 320373001634 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 320373001635 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 320373001636 SLBB domain; Region: SLBB; pfam10531 320373001637 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 320373001638 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 320373001639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373001640 CHRD domain; Region: CHRD; pfam07452 320373001641 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 320373001642 EcsC protein family; Region: EcsC; pfam12787 320373001643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373001644 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373001645 putative substrate translocation pore; other site 320373001646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373001647 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320373001648 MarR family; Region: MarR; pfam01047 320373001649 MarR family; Region: MarR_2; cl17246 320373001650 intracellular protease, PfpI family; Region: PfpI; TIGR01382 320373001651 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 320373001652 conserved cys residue [active] 320373001653 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 320373001654 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 320373001655 dimer interface [polypeptide binding]; other site 320373001656 active site 320373001657 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320373001658 substrate binding site [chemical binding]; other site 320373001659 catalytic residue [active] 320373001660 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320373001661 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320373001662 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320373001663 putative active site [active] 320373001664 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 320373001665 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 320373001666 active site 320373001667 putative substrate binding pocket [chemical binding]; other site 320373001668 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 320373001669 homotrimer interaction site [polypeptide binding]; other site 320373001670 putative active site [active] 320373001671 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 320373001672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 320373001673 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 320373001674 threonine dehydratase; Reviewed; Region: PRK09224 320373001675 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 320373001676 tetramer interface [polypeptide binding]; other site 320373001677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373001678 catalytic residue [active] 320373001679 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 320373001680 putative Ile/Val binding site [chemical binding]; other site 320373001681 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 320373001682 putative Ile/Val binding site [chemical binding]; other site 320373001683 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 320373001684 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320373001685 FAD binding domain; Region: FAD_binding_4; pfam01565 320373001686 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320373001687 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 320373001688 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 320373001689 Cysteine-rich domain; Region: CCG; pfam02754 320373001690 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 320373001691 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 320373001692 nucleotide binding site/active site [active] 320373001693 HIT family signature motif; other site 320373001694 catalytic residue [active] 320373001695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 320373001696 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 320373001697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373001698 S-adenosylmethionine binding site [chemical binding]; other site 320373001699 Tim44-like domain; Region: Tim44; pfam04280 320373001700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 320373001701 SCP-2 sterol transfer family; Region: SCP2; pfam02036 320373001702 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 320373001703 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 320373001704 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 320373001705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320373001706 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 320373001707 Uncharacterized conserved protein [Function unknown]; Region: COG2928 320373001708 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 320373001709 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 320373001710 dimer interface [polypeptide binding]; other site 320373001711 anticodon binding site; other site 320373001712 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 320373001713 homodimer interface [polypeptide binding]; other site 320373001714 motif 1; other site 320373001715 active site 320373001716 motif 2; other site 320373001717 GAD domain; Region: GAD; pfam02938 320373001718 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 320373001719 motif 3; other site 320373001720 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 320373001721 nudix motif; other site 320373001722 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 320373001723 PLD-like domain; Region: PLDc_2; pfam13091 320373001724 putative active site [active] 320373001725 catalytic site [active] 320373001726 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 320373001727 PLD-like domain; Region: PLDc_2; pfam13091 320373001728 putative active site [active] 320373001729 catalytic site [active] 320373001730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373001731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373001732 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 320373001733 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 320373001734 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 320373001735 FAD binding site [chemical binding]; other site 320373001736 substrate binding site [chemical binding]; other site 320373001737 catalytic residues [active] 320373001738 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 320373001739 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 320373001740 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320373001741 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320373001742 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 320373001743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373001744 substrate binding site [chemical binding]; other site 320373001745 oxyanion hole (OAH) forming residues; other site 320373001746 trimer interface [polypeptide binding]; other site 320373001747 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 320373001748 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320373001749 dimer interface [polypeptide binding]; other site 320373001750 active site 320373001751 enoyl-CoA hydratase; Provisional; Region: PRK06688 320373001752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373001753 substrate binding site [chemical binding]; other site 320373001754 oxyanion hole (OAH) forming residues; other site 320373001755 trimer interface [polypeptide binding]; other site 320373001756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 320373001757 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 320373001758 conserved hypothetical protein; Region: nitr_red_assoc; TIGR02664 320373001759 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 320373001760 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 320373001761 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320373001762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373001763 Walker A/P-loop; other site 320373001764 ATP binding site [chemical binding]; other site 320373001765 Q-loop/lid; other site 320373001766 ABC transporter signature motif; other site 320373001767 Walker B; other site 320373001768 D-loop; other site 320373001769 H-loop/switch region; other site 320373001770 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 320373001771 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 320373001772 Substrate binding site; other site 320373001773 metal-binding site 320373001774 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 320373001775 Phosphotransferase enzyme family; Region: APH; pfam01636 320373001776 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 320373001777 Organic solvent tolerance protein; Region: OstA_C; pfam04453 320373001778 SurA N-terminal domain; Region: SurA_N; pfam09312 320373001779 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 320373001780 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320373001781 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320373001782 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 320373001783 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 320373001784 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 320373001785 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 320373001786 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 320373001787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373001788 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 320373001789 dimer interface [polypeptide binding]; other site 320373001790 active site 320373001791 metal binding site [ion binding]; metal-binding site 320373001792 glutathione binding site [chemical binding]; other site 320373001793 Protein of unknown function DUF45; Region: DUF45; pfam01863 320373001794 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 320373001795 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 320373001796 putative acyl-acceptor binding pocket; other site 320373001797 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 320373001798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373001799 active site 320373001800 motif I; other site 320373001801 motif II; other site 320373001802 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 320373001803 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 320373001804 dimer interface [polypeptide binding]; other site 320373001805 motif 1; other site 320373001806 active site 320373001807 motif 2; other site 320373001808 motif 3; other site 320373001809 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 320373001810 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 320373001811 putative active site [active] 320373001812 catalytic triad [active] 320373001813 putative dimer interface [polypeptide binding]; other site 320373001814 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 320373001815 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 320373001816 Transporter associated domain; Region: CorC_HlyC; smart01091 320373001817 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 320373001818 putative active site pocket [active] 320373001819 dimerization interface [polypeptide binding]; other site 320373001820 putative catalytic residue [active] 320373001821 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 320373001822 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 320373001823 PhoH-like protein; Region: PhoH; pfam02562 320373001824 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 320373001825 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 320373001826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373001827 FeS/SAM binding site; other site 320373001828 TRAM domain; Region: TRAM; pfam01938 320373001829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373001830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373001831 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373001832 putative effector binding pocket; other site 320373001833 dimerization interface [polypeptide binding]; other site 320373001834 MFS transport protein AraJ; Provisional; Region: PRK10091 320373001835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373001836 putative substrate translocation pore; other site 320373001837 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320373001838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373001839 non-specific DNA binding site [nucleotide binding]; other site 320373001840 salt bridge; other site 320373001841 sequence-specific DNA binding site [nucleotide binding]; other site 320373001842 Cupin domain; Region: Cupin_2; pfam07883 320373001843 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 320373001844 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 320373001845 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 320373001846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373001847 motif II; other site 320373001848 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 320373001849 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 320373001850 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 320373001851 active site 320373001852 dimer interface [polypeptide binding]; other site 320373001853 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 320373001854 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 320373001855 Ligand Binding Site [chemical binding]; other site 320373001856 Molecular Tunnel; other site 320373001857 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 320373001858 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 320373001859 hinge; other site 320373001860 active site 320373001861 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 320373001862 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 320373001863 putative active site [active] 320373001864 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 320373001865 homotrimer interaction site [polypeptide binding]; other site 320373001866 putative active site [active] 320373001867 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 320373001868 amphipathic channel; other site 320373001869 Asn-Pro-Ala signature motifs; other site 320373001870 glycerol kinase; Provisional; Region: glpK; PRK00047 320373001871 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 320373001872 N- and C-terminal domain interface [polypeptide binding]; other site 320373001873 active site 320373001874 MgATP binding site [chemical binding]; other site 320373001875 catalytic site [active] 320373001876 metal binding site [ion binding]; metal-binding site 320373001877 glycerol binding site [chemical binding]; other site 320373001878 homotetramer interface [polypeptide binding]; other site 320373001879 homodimer interface [polypeptide binding]; other site 320373001880 FBP binding site [chemical binding]; other site 320373001881 protein IIAGlc interface [polypeptide binding]; other site 320373001882 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 320373001883 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 320373001884 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 320373001885 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 320373001886 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 320373001887 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 320373001888 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 320373001889 dinuclear metal binding motif [ion binding]; other site 320373001890 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 320373001891 ATP binding site [chemical binding]; other site 320373001892 Mg++ binding site [ion binding]; other site 320373001893 motif III; other site 320373001894 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373001895 nucleotide binding region [chemical binding]; other site 320373001896 ATP-binding site [chemical binding]; other site 320373001897 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373001898 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373001899 Cytochrome c; Region: Cytochrom_C; pfam00034 320373001900 Cytochrome c; Region: Cytochrom_C; cl11414 320373001901 Cytochrome c; Region: Cytochrom_C; cl11414 320373001902 Copper resistance protein D; Region: CopD; pfam05425 320373001903 galactonate dehydratase; Provisional; Region: PRK14017 320373001904 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 320373001905 putative active site pocket [active] 320373001906 putative metal binding site [ion binding]; other site 320373001907 Uncharacterized conserved protein [Function unknown]; Region: COG3791 320373001908 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 320373001909 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320373001910 active site 320373001911 metal binding site [ion binding]; metal-binding site 320373001912 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 320373001913 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 320373001914 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 320373001915 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 320373001916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373001917 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 320373001918 linker region; other site 320373001919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373001920 ATP binding site [chemical binding]; other site 320373001921 Mg2+ binding site [ion binding]; other site 320373001922 G-X-G motif; other site 320373001923 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 320373001924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373001925 active site 320373001926 phosphorylation site [posttranslational modification] 320373001927 intermolecular recognition site; other site 320373001928 dimerization interface [polypeptide binding]; other site 320373001929 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320373001930 Zn2+ binding site [ion binding]; other site 320373001931 Mg2+ binding site [ion binding]; other site 320373001932 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 320373001933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373001934 PAS domain; Region: PAS_9; pfam13426 320373001935 putative active site [active] 320373001936 heme pocket [chemical binding]; other site 320373001937 HAMP domain; Region: HAMP; pfam00672 320373001938 dimerization interface [polypeptide binding]; other site 320373001939 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320373001940 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373001941 dimer interface [polypeptide binding]; other site 320373001942 putative CheW interface [polypeptide binding]; other site 320373001943 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320373001944 FAD binding domain; Region: FAD_binding_4; pfam01565 320373001945 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 320373001946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373001947 dimerization interface [polypeptide binding]; other site 320373001948 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 320373001949 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 320373001950 active site residue [active] 320373001951 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 320373001952 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320373001953 Walker A/P-loop; other site 320373001954 ATP binding site [chemical binding]; other site 320373001955 Q-loop/lid; other site 320373001956 ABC transporter signature motif; other site 320373001957 Walker B; other site 320373001958 D-loop; other site 320373001959 H-loop/switch region; other site 320373001960 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 320373001961 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 320373001962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373001963 dimer interface [polypeptide binding]; other site 320373001964 conserved gate region; other site 320373001965 putative PBP binding loops; other site 320373001966 ABC-ATPase subunit interface; other site 320373001967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373001968 dimer interface [polypeptide binding]; other site 320373001969 ABC-ATPase subunit interface; other site 320373001970 putative PBP binding loops; other site 320373001971 Erythromycin esterase; Region: Erythro_esteras; pfam05139 320373001972 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 320373001973 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 320373001974 active site 320373001975 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373001976 active site 320373001977 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 320373001978 Transglycosylase; Region: Transgly; cl17702 320373001979 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320373001980 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373001981 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373001982 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 320373001983 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 320373001984 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 320373001985 D-pathway; other site 320373001986 Putative ubiquinol binding site [chemical binding]; other site 320373001987 Low-spin heme (heme b) binding site [chemical binding]; other site 320373001988 Putative water exit pathway; other site 320373001989 Binuclear center (heme o3/CuB) [ion binding]; other site 320373001990 K-pathway; other site 320373001991 Putative proton exit pathway; other site 320373001992 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 320373001993 Subunit I/III interface [polypeptide binding]; other site 320373001994 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320373001995 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 320373001996 Cytochrome c; Region: Cytochrom_C; pfam00034 320373001997 thiamine pyrophosphate protein; Provisional; Region: PRK08273 320373001998 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 320373001999 PYR/PP interface [polypeptide binding]; other site 320373002000 dimer interface [polypeptide binding]; other site 320373002001 tetramer interface [polypeptide binding]; other site 320373002002 TPP binding site [chemical binding]; other site 320373002003 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373002004 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 320373002005 TPP-binding site [chemical binding]; other site 320373002006 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 320373002007 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 320373002008 metal binding site [ion binding]; metal-binding site 320373002009 substrate binding pocket [chemical binding]; other site 320373002010 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 320373002011 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 320373002012 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320373002013 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320373002014 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 320373002015 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 320373002016 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 320373002017 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 320373002018 active site 320373002019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373002020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373002021 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 320373002022 putative effector binding pocket; other site 320373002023 putative dimerization interface [polypeptide binding]; other site 320373002024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 320373002025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373002026 dimer interface [polypeptide binding]; other site 320373002027 phosphorylation site [posttranslational modification] 320373002028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373002029 ATP binding site [chemical binding]; other site 320373002030 Mg2+ binding site [ion binding]; other site 320373002031 G-X-G motif; other site 320373002032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373002033 Response regulator receiver domain; Region: Response_reg; pfam00072 320373002034 active site 320373002035 phosphorylation site [posttranslational modification] 320373002036 intermolecular recognition site; other site 320373002037 dimerization interface [polypeptide binding]; other site 320373002038 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 320373002039 BetR domain; Region: BetR; pfam08667 320373002040 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 320373002041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373002042 active site 320373002043 phosphorylation site [posttranslational modification] 320373002044 intermolecular recognition site; other site 320373002045 dimerization interface [polypeptide binding]; other site 320373002046 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 320373002047 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 320373002048 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 320373002049 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 320373002050 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 320373002051 Malic enzyme, N-terminal domain; Region: malic; pfam00390 320373002052 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 320373002053 NAD(P) binding pocket [chemical binding]; other site 320373002054 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373002055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373002056 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373002057 dimerization interface [polypeptide binding]; other site 320373002058 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 320373002059 EamA-like transporter family; Region: EamA; cl17759 320373002060 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 320373002061 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 320373002062 metal binding site [ion binding]; metal-binding site 320373002063 substrate binding pocket [chemical binding]; other site 320373002064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373002065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373002066 DNA binding residues [nucleotide binding] 320373002067 dimerization interface [polypeptide binding]; other site 320373002068 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 320373002069 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 320373002070 hinge; other site 320373002071 active site 320373002072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373002073 putative substrate translocation pore; other site 320373002074 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 320373002075 HAMP domain; Region: HAMP; pfam00672 320373002076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373002077 dimer interface [polypeptide binding]; other site 320373002078 phosphorylation site [posttranslational modification] 320373002079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373002080 ATP binding site [chemical binding]; other site 320373002081 Mg2+ binding site [ion binding]; other site 320373002082 G-X-G motif; other site 320373002083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373002084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373002085 active site 320373002086 phosphorylation site [posttranslational modification] 320373002087 intermolecular recognition site; other site 320373002088 dimerization interface [polypeptide binding]; other site 320373002089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373002090 DNA binding site [nucleotide binding] 320373002091 recombinase A; Provisional; Region: recA; PRK09354 320373002092 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 320373002093 hexamer interface [polypeptide binding]; other site 320373002094 Walker A motif; other site 320373002095 ATP binding site [chemical binding]; other site 320373002096 Walker B motif; other site 320373002097 recombination regulator RecX; Provisional; Region: recX; PRK14136 320373002098 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 320373002099 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 320373002100 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 320373002101 CoA-ligase; Region: Ligase_CoA; pfam00549 320373002102 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 320373002103 CoA binding domain; Region: CoA_binding; smart00881 320373002104 CoA-ligase; Region: Ligase_CoA; pfam00549 320373002105 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 320373002106 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 320373002107 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 320373002108 O-Antigen ligase; Region: Wzy_C; pfam04932 320373002109 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 320373002110 hypothetical protein; Provisional; Region: PRK11667 320373002111 Gram-negative bacterial tonB protein; Region: TonB; cl10048 320373002112 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 320373002113 trimer interface [polypeptide binding]; other site 320373002114 dimer interface [polypeptide binding]; other site 320373002115 putative active site [active] 320373002116 Peptidase family M48; Region: Peptidase_M48; pfam01435 320373002117 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 320373002118 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 320373002119 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 320373002120 SnoaL-like domain; Region: SnoaL_3; pfam13474 320373002121 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320373002122 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373002123 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373002124 putative active site [active] 320373002125 Zinc-finger domain; Region: zf-CHCC; cl01821 320373002126 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 320373002127 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 320373002128 homodimer interface [polypeptide binding]; other site 320373002129 substrate-cofactor binding pocket; other site 320373002130 catalytic residue [active] 320373002131 AzlC protein; Region: AzlC; cl00570 320373002132 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 320373002133 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 320373002134 Phosphoglycerate kinase; Region: PGK; pfam00162 320373002135 substrate binding site [chemical binding]; other site 320373002136 hinge regions; other site 320373002137 ADP binding site [chemical binding]; other site 320373002138 catalytic site [active] 320373002139 pyruvate kinase; Provisional; Region: PRK05826 320373002140 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 320373002141 domain interfaces; other site 320373002142 active site 320373002143 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 320373002144 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 320373002145 intersubunit interface [polypeptide binding]; other site 320373002146 active site 320373002147 zinc binding site [ion binding]; other site 320373002148 Na+ binding site [ion binding]; other site 320373002149 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 320373002150 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 320373002151 ATP binding site [chemical binding]; other site 320373002152 active site 320373002153 substrate binding site [chemical binding]; other site 320373002154 AIR carboxylase; Region: AIRC; pfam00731 320373002155 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 320373002156 ATP-grasp domain; Region: ATP-grasp; pfam02222 320373002157 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 320373002158 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 320373002159 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 320373002160 active site 320373002161 catalytic triad [active] 320373002162 oxyanion hole [active] 320373002163 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 320373002164 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 320373002165 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 320373002166 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 320373002167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373002168 active site 320373002169 phosphorylation site [posttranslational modification] 320373002170 intermolecular recognition site; other site 320373002171 dimerization interface [polypeptide binding]; other site 320373002172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373002173 DNA binding site [nucleotide binding] 320373002174 sensor protein QseC; Provisional; Region: PRK10337 320373002175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373002176 ATP binding site [chemical binding]; other site 320373002177 Mg2+ binding site [ion binding]; other site 320373002178 G-X-G motif; other site 320373002179 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 320373002180 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 320373002181 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320373002182 protein binding site [polypeptide binding]; other site 320373002183 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320373002184 protein binding site [polypeptide binding]; other site 320373002185 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 320373002186 Domain of unknown function (DUF427); Region: DUF427; pfam04248 320373002187 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 320373002188 hydrophobic ligand binding site; other site 320373002189 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 320373002190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373002191 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 320373002192 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 320373002193 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373002194 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373002195 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 320373002196 Protein export membrane protein; Region: SecD_SecF; cl14618 320373002197 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 320373002198 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 320373002199 xanthine permease; Region: pbuX; TIGR03173 320373002200 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 320373002201 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 320373002202 nucleotide binding site [chemical binding]; other site 320373002203 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320373002204 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 320373002205 conserved cys residue [active] 320373002206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373002207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373002208 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 320373002209 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 320373002210 substrate binding site [chemical binding]; other site 320373002211 catalytic Zn binding site [ion binding]; other site 320373002212 NAD binding site [chemical binding]; other site 320373002213 structural Zn binding site [ion binding]; other site 320373002214 dimer interface [polypeptide binding]; other site 320373002215 S-formylglutathione hydrolase; Region: PLN02442 320373002216 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 320373002217 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 320373002218 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 320373002219 dimer interface [polypeptide binding]; other site 320373002220 putative PBP binding regions; other site 320373002221 ABC-ATPase subunit interface; other site 320373002222 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 320373002223 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 320373002224 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 320373002225 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 320373002226 metal binding site [ion binding]; metal-binding site 320373002227 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 320373002228 metal binding site 2 [ion binding]; metal-binding site 320373002229 putative DNA binding helix; other site 320373002230 metal binding site 1 [ion binding]; metal-binding site 320373002231 dimer interface [polypeptide binding]; other site 320373002232 structural Zn2+ binding site [ion binding]; other site 320373002233 sorbitol dehydrogenase; Provisional; Region: PRK07067 320373002234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373002235 NAD(P) binding site [chemical binding]; other site 320373002236 active site 320373002237 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320373002238 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 320373002239 substrate binding site [chemical binding]; other site 320373002240 ATP binding site [chemical binding]; other site 320373002241 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 320373002242 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 320373002243 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 320373002244 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320373002245 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 320373002246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373002247 dimer interface [polypeptide binding]; other site 320373002248 conserved gate region; other site 320373002249 putative PBP binding loops; other site 320373002250 ABC-ATPase subunit interface; other site 320373002251 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 320373002252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373002253 dimer interface [polypeptide binding]; other site 320373002254 conserved gate region; other site 320373002255 putative PBP binding loops; other site 320373002256 ABC-ATPase subunit interface; other site 320373002257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373002258 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 320373002259 active site 320373002260 motif I; other site 320373002261 motif II; other site 320373002262 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 320373002263 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 320373002264 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 320373002265 Walker A/P-loop; other site 320373002266 ATP binding site [chemical binding]; other site 320373002267 Q-loop/lid; other site 320373002268 ABC transporter signature motif; other site 320373002269 Walker B; other site 320373002270 D-loop; other site 320373002271 H-loop/switch region; other site 320373002272 TOBE domain; Region: TOBE; pfam03459 320373002273 TOBE domain; Region: TOBE_2; pfam08402 320373002274 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 320373002275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373002276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373002277 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 320373002278 putative effector binding pocket; other site 320373002279 putative dimerization interface [polypeptide binding]; other site 320373002280 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 320373002281 Beta-lactamase; Region: Beta-lactamase; pfam00144 320373002282 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320373002283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373002284 putative substrate translocation pore; other site 320373002285 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 320373002286 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 320373002287 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 320373002288 N- and C-terminal domain interface [polypeptide binding]; other site 320373002289 D-xylulose kinase; Region: XylB; TIGR01312 320373002290 active site 320373002291 MgATP binding site [chemical binding]; other site 320373002292 catalytic site [active] 320373002293 metal binding site [ion binding]; metal-binding site 320373002294 xylulose binding site [chemical binding]; other site 320373002295 homodimer interface [polypeptide binding]; other site 320373002296 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 320373002297 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 320373002298 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 320373002299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373002300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373002301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373002302 dimerization interface [polypeptide binding]; other site 320373002303 benzoylformate decarboxylase; Reviewed; Region: PRK07092 320373002304 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373002305 PYR/PP interface [polypeptide binding]; other site 320373002306 dimer interface [polypeptide binding]; other site 320373002307 TPP binding site [chemical binding]; other site 320373002308 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373002309 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 320373002310 TPP-binding site [chemical binding]; other site 320373002311 dimer interface [polypeptide binding]; other site 320373002312 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 320373002313 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 320373002314 NAD(P) binding site [chemical binding]; other site 320373002315 catalytic residues [active] 320373002316 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 320373002317 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 320373002318 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 320373002319 benzoate transport; Region: 2A0115; TIGR00895 320373002320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373002321 putative substrate translocation pore; other site 320373002322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373002323 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 320373002324 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 320373002325 kynureninase; Region: kynureninase; TIGR01814 320373002326 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373002327 catalytic residue [active] 320373002328 Putative cyclase; Region: Cyclase; cl00814 320373002329 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373002330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373002331 putative DNA binding site [nucleotide binding]; other site 320373002332 putative Zn2+ binding site [ion binding]; other site 320373002333 AsnC family; Region: AsnC_trans_reg; pfam01037 320373002334 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 320373002335 methionine sulfoxide reductase A; Provisional; Region: PRK14054 320373002336 Protein of unknown function DUF72; Region: DUF72; pfam01904 320373002337 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 320373002338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373002339 S-adenosylmethionine binding site [chemical binding]; other site 320373002340 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 320373002341 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 320373002342 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 320373002343 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 320373002344 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 320373002345 putative ATP binding site [chemical binding]; other site 320373002346 putative substrate interface [chemical binding]; other site 320373002347 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 320373002348 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320373002349 catalytic residues [active] 320373002350 Pirin-related protein [General function prediction only]; Region: COG1741 320373002351 Pirin; Region: Pirin; pfam02678 320373002352 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 320373002353 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 320373002354 EamA-like transporter family; Region: EamA; pfam00892 320373002355 AMIN domain; Region: AMIN; pfam11741 320373002356 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 320373002357 active site 320373002358 metal binding site [ion binding]; metal-binding site 320373002359 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 320373002360 epoxyqueuosine reductase; Region: TIGR00276 320373002361 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 320373002362 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 320373002363 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 320373002364 DNA binding site [nucleotide binding] 320373002365 active site 320373002366 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 320373002367 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 320373002368 active site 320373002369 Int/Topo IB signature motif; other site 320373002370 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 320373002371 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373002372 acyl-activating enzyme (AAE) consensus motif; other site 320373002373 AMP binding site [chemical binding]; other site 320373002374 active site 320373002375 CoA binding site [chemical binding]; other site 320373002376 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 320373002377 putative deacylase active site [active] 320373002378 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 320373002379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 320373002380 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 320373002381 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 320373002382 FAD binding domain; Region: FAD_binding_4; pfam01565 320373002383 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 320373002384 ornithine carbamoyltransferase; Provisional; Region: PRK00779 320373002385 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 320373002386 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 320373002387 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 320373002388 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 320373002389 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 320373002390 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 320373002391 Uncharacterized conserved protein [Function unknown]; Region: COG2912 320373002392 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 320373002393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373002394 NAD(P) binding site [chemical binding]; other site 320373002395 active site 320373002396 adenylate kinase; Reviewed; Region: adk; PRK00279 320373002397 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 320373002398 AMP-binding site [chemical binding]; other site 320373002399 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 320373002400 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 320373002401 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 320373002402 Ligand binding site; other site 320373002403 oligomer interface; other site 320373002404 Uncharacterized conserved protein [Function unknown]; Region: COG2835 320373002405 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 320373002406 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 320373002407 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 320373002408 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 320373002409 generic binding surface II; other site 320373002410 generic binding surface I; other site 320373002411 superoxide dismutase; Provisional; Region: PRK10543 320373002412 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 320373002413 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 320373002414 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 320373002415 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 320373002416 Chromate transporter; Region: Chromate_transp; pfam02417 320373002417 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320373002418 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320373002419 ligand binding site [chemical binding]; other site 320373002420 flexible hinge region; other site 320373002421 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 320373002422 putative switch regulator; other site 320373002423 non-specific DNA interactions [nucleotide binding]; other site 320373002424 DNA binding site [nucleotide binding] 320373002425 sequence specific DNA binding site [nucleotide binding]; other site 320373002426 putative cAMP binding site [chemical binding]; other site 320373002427 Predicted membrane protein [Function unknown]; Region: COG4539 320373002428 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 320373002429 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 320373002430 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 320373002431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373002432 S-adenosylmethionine binding site [chemical binding]; other site 320373002433 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373002434 putative transporter; Provisional; Region: PRK10504 320373002435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373002436 putative substrate translocation pore; other site 320373002437 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 320373002438 Helix-turn-helix domain; Region: HTH_17; pfam12728 320373002439 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 320373002440 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 320373002441 dimer interface [polypeptide binding]; other site 320373002442 active site 320373002443 oxalacetate/citrate binding site [chemical binding]; other site 320373002444 citrylCoA binding site [chemical binding]; other site 320373002445 coenzyme A binding site [chemical binding]; other site 320373002446 catalytic triad [active] 320373002447 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 320373002448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373002449 DNA-binding site [nucleotide binding]; DNA binding site 320373002450 UTRA domain; Region: UTRA; pfam07702 320373002451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320373002452 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 320373002453 active site 320373002454 catalytic tetrad [active] 320373002455 elongation factor G; Reviewed; Region: PRK00007 320373002456 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 320373002457 G1 box; other site 320373002458 putative GEF interaction site [polypeptide binding]; other site 320373002459 GTP/Mg2+ binding site [chemical binding]; other site 320373002460 Switch I region; other site 320373002461 G2 box; other site 320373002462 G3 box; other site 320373002463 Switch II region; other site 320373002464 G4 box; other site 320373002465 G5 box; other site 320373002466 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 320373002467 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 320373002468 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 320373002469 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 320373002470 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 320373002471 pseudouridine synthase; Region: TIGR00093 320373002472 active site 320373002473 isocitrate dehydrogenase; Validated; Region: PRK07362 320373002474 isocitrate dehydrogenase; Reviewed; Region: PRK07006 320373002475 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 320373002476 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 320373002477 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 320373002478 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 320373002479 DNA-binding site [nucleotide binding]; DNA binding site 320373002480 RNA-binding motif; other site 320373002481 Uncharacterized conserved protein [Function unknown]; Region: COG2127 320373002482 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 320373002483 Clp amino terminal domain; Region: Clp_N; pfam02861 320373002484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373002485 Walker A motif; other site 320373002486 ATP binding site [chemical binding]; other site 320373002487 Walker B motif; other site 320373002488 arginine finger; other site 320373002489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373002490 Walker A motif; other site 320373002491 ATP binding site [chemical binding]; other site 320373002492 Walker B motif; other site 320373002493 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320373002494 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 320373002495 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 320373002496 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320373002497 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320373002498 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320373002499 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 320373002500 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 320373002501 trimer interface [polypeptide binding]; other site 320373002502 active site 320373002503 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 320373002504 Flavoprotein; Region: Flavoprotein; pfam02441 320373002505 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 320373002506 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 320373002507 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 320373002508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320373002509 active site 320373002510 HIGH motif; other site 320373002511 nucleotide binding site [chemical binding]; other site 320373002512 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 320373002513 active site 320373002514 KMSKS motif; other site 320373002515 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 320373002516 tRNA binding surface [nucleotide binding]; other site 320373002517 anticodon binding site; other site 320373002518 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 320373002519 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 320373002520 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 320373002521 active site 320373002522 Riboflavin kinase; Region: Flavokinase; smart00904 320373002523 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 320373002524 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 320373002525 active site 320373002526 substrate binding site [chemical binding]; other site 320373002527 cosubstrate binding site; other site 320373002528 catalytic site [active] 320373002529 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 320373002530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373002531 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 320373002532 Mechanosensitive ion channel; Region: MS_channel; pfam00924 320373002533 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 320373002534 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320373002535 Di-iron ligands [ion binding]; other site 320373002536 Transposase; Region: DDE_Tnp_ISL3; pfam01610 320373002537 quinolinate synthetase; Provisional; Region: PRK09375 320373002538 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 320373002539 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 320373002540 dimerization interface [polypeptide binding]; other site 320373002541 active site 320373002542 L-aspartate oxidase; Provisional; Region: PRK09077 320373002543 L-aspartate oxidase; Provisional; Region: PRK06175 320373002544 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 320373002545 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 320373002546 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 320373002547 hypothetical protein; Reviewed; Region: PRK00024 320373002548 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 320373002549 MPN+ (JAMM) motif; other site 320373002550 Zinc-binding site [ion binding]; other site 320373002551 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 320373002552 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 320373002553 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 320373002554 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 320373002555 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373002556 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320373002557 TM-ABC transporter signature motif; other site 320373002558 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320373002559 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320373002560 TM-ABC transporter signature motif; other site 320373002561 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320373002562 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320373002563 Walker A/P-loop; other site 320373002564 ATP binding site [chemical binding]; other site 320373002565 Q-loop/lid; other site 320373002566 ABC transporter signature motif; other site 320373002567 Walker B; other site 320373002568 D-loop; other site 320373002569 H-loop/switch region; other site 320373002570 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320373002571 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320373002572 Walker A/P-loop; other site 320373002573 ATP binding site [chemical binding]; other site 320373002574 Q-loop/lid; other site 320373002575 ABC transporter signature motif; other site 320373002576 Walker B; other site 320373002577 D-loop; other site 320373002578 H-loop/switch region; other site 320373002579 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 320373002580 putative acetyltransferase; Provisional; Region: PRK03624 320373002581 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320373002582 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 320373002583 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373002584 inhibitor-cofactor binding pocket; inhibition site 320373002585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373002586 catalytic residue [active] 320373002587 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 320373002588 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373002589 catalytic loop [active] 320373002590 iron binding site [ion binding]; other site 320373002591 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 320373002592 FAD binding pocket [chemical binding]; other site 320373002593 FAD binding motif [chemical binding]; other site 320373002594 phosphate binding motif [ion binding]; other site 320373002595 beta-alpha-beta structure motif; other site 320373002596 NAD binding pocket [chemical binding]; other site 320373002597 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320373002598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373002599 NAD(P) binding site [chemical binding]; other site 320373002600 active site 320373002601 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320373002602 RNA binding surface [nucleotide binding]; other site 320373002603 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 320373002604 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 320373002605 active site 320373002606 uracil binding [chemical binding]; other site 320373002607 CopC domain; Region: CopC; pfam04234 320373002608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373002609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373002610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373002611 dimerization interface [polypeptide binding]; other site 320373002612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373002613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373002614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373002615 dimerization interface [polypeptide binding]; other site 320373002616 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373002617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 320373002618 MOSC domain; Region: MOSC; pfam03473 320373002619 3-alpha domain; Region: 3-alpha; pfam03475 320373002620 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 320373002621 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 320373002622 inhibitor site; inhibition site 320373002623 active site 320373002624 dimer interface [polypeptide binding]; other site 320373002625 catalytic residue [active] 320373002626 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 320373002627 intersubunit interface [polypeptide binding]; other site 320373002628 active site 320373002629 Zn2+ binding site [ion binding]; other site 320373002630 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320373002631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373002632 non-specific DNA binding site [nucleotide binding]; other site 320373002633 salt bridge; other site 320373002634 sequence-specific DNA binding site [nucleotide binding]; other site 320373002635 Cupin domain; Region: Cupin_2; pfam07883 320373002636 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 320373002637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373002638 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 320373002639 substrate binding site [chemical binding]; other site 320373002640 dimerization interface [polypeptide binding]; other site 320373002641 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 320373002642 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320373002643 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320373002644 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 320373002645 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 320373002646 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 320373002647 Active Sites [active] 320373002648 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 320373002649 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 320373002650 Active Sites [active] 320373002651 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 320373002652 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 320373002653 CysD dimerization site [polypeptide binding]; other site 320373002654 G1 box; other site 320373002655 putative GEF interaction site [polypeptide binding]; other site 320373002656 GTP/Mg2+ binding site [chemical binding]; other site 320373002657 Switch I region; other site 320373002658 G2 box; other site 320373002659 G3 box; other site 320373002660 Switch II region; other site 320373002661 G4 box; other site 320373002662 G5 box; other site 320373002663 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 320373002664 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 320373002665 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 320373002666 active site 320373002667 SAM binding site [chemical binding]; other site 320373002668 homodimer interface [polypeptide binding]; other site 320373002669 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 320373002670 putative active site [active] 320373002671 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 320373002672 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 320373002673 Predicted permeases [General function prediction only]; Region: COG0795 320373002674 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 320373002675 multifunctional aminopeptidase A; Provisional; Region: PRK00913 320373002676 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 320373002677 interface (dimer of trimers) [polypeptide binding]; other site 320373002678 Substrate-binding/catalytic site; other site 320373002679 Zn-binding sites [ion binding]; other site 320373002680 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 320373002681 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 320373002682 Cytochrome c; Region: Cytochrom_C; cl11414 320373002683 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 320373002684 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 320373002685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373002686 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 320373002687 putative dimerization interface [polypeptide binding]; other site 320373002688 putative substrate binding pocket [chemical binding]; other site 320373002689 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 320373002690 Protein of unknown function (DUF541); Region: SIMPL; cl01077 320373002691 Uncharacterized conserved protein [Function unknown]; Region: COG2947 320373002692 Cell division protein ZapA; Region: ZapA; pfam05164 320373002693 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 320373002694 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 320373002695 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373002696 N-terminal plug; other site 320373002697 ligand-binding site [chemical binding]; other site 320373002698 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 320373002699 ABC-ATPase subunit interface; other site 320373002700 dimer interface [polypeptide binding]; other site 320373002701 putative PBP binding regions; other site 320373002702 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 320373002703 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 320373002704 Walker A/P-loop; other site 320373002705 ATP binding site [chemical binding]; other site 320373002706 Q-loop/lid; other site 320373002707 ABC transporter signature motif; other site 320373002708 Walker B; other site 320373002709 D-loop; other site 320373002710 H-loop/switch region; other site 320373002711 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 320373002712 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 320373002713 putative dimer interface [polypeptide binding]; other site 320373002714 active site pocket [active] 320373002715 putative cataytic base [active] 320373002716 cobalamin synthase; Reviewed; Region: cobS; PRK00235 320373002717 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320373002718 catalytic core [active] 320373002719 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 320373002720 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 320373002721 cobalamin binding residues [chemical binding]; other site 320373002722 putative BtuC binding residues; other site 320373002723 dimer interface [polypeptide binding]; other site 320373002724 putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959 320373002725 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 320373002726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373002727 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 320373002728 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 320373002729 homotrimer interface [polypeptide binding]; other site 320373002730 Walker A motif; other site 320373002731 GTP binding site [chemical binding]; other site 320373002732 Walker B motif; other site 320373002733 cobyric acid synthase; Provisional; Region: PRK00784 320373002734 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 320373002735 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 320373002736 catalytic triad [active] 320373002737 DoxX; Region: DoxX; pfam07681 320373002738 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 320373002739 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320373002740 P-loop; other site 320373002741 Magnesium ion binding site [ion binding]; other site 320373002742 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 320373002743 tetramerization interface [polypeptide binding]; other site 320373002744 active site 320373002745 pantoate--beta-alanine ligase; Region: panC; TIGR00018 320373002746 Pantoate-beta-alanine ligase; Region: PanC; cd00560 320373002747 active site 320373002748 ATP-binding site [chemical binding]; other site 320373002749 pantoate-binding site; other site 320373002750 HXXH motif; other site 320373002751 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 320373002752 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 320373002753 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 320373002754 Surface antigen; Region: Bac_surface_Ag; pfam01103 320373002755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 320373002756 Family of unknown function (DUF490); Region: DUF490; pfam04357 320373002757 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 320373002758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373002759 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 320373002760 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 320373002761 active site 320373002762 HIGH motif; other site 320373002763 KMSKS motif; other site 320373002764 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 320373002765 tRNA binding surface [nucleotide binding]; other site 320373002766 anticodon binding site; other site 320373002767 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 320373002768 dimer interface [polypeptide binding]; other site 320373002769 putative tRNA-binding site [nucleotide binding]; other site 320373002770 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 320373002771 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373002772 ligand binding site [chemical binding]; other site 320373002773 Domain of unknown function DUF59; Region: DUF59; pfam01883 320373002774 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 320373002775 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 320373002776 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 320373002777 E-class dimer interface [polypeptide binding]; other site 320373002778 P-class dimer interface [polypeptide binding]; other site 320373002779 active site 320373002780 Cu2+ binding site [ion binding]; other site 320373002781 Zn2+ binding site [ion binding]; other site 320373002782 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 320373002783 trimer interface [polypeptide binding]; other site 320373002784 active site 320373002785 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 320373002786 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 320373002787 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373002788 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373002789 catalytic residue [active] 320373002790 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 320373002791 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 320373002792 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 320373002793 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 320373002794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373002795 motif II; other site 320373002796 argininosuccinate lyase; Provisional; Region: PRK00855 320373002797 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 320373002798 active sites [active] 320373002799 tetramer interface [polypeptide binding]; other site 320373002800 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 320373002801 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 320373002802 PapC C-terminal domain; Region: PapC_C; pfam13953 320373002803 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 320373002804 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 320373002805 Uncharacterized secreted protein [Function unknown]; Region: COG5430 320373002806 Spore Coat Protein U domain; Region: SCPU; pfam05229 320373002807 Spore Coat Protein U domain; Region: SCPU; pfam05229 320373002808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373002809 sequence-specific DNA binding site [nucleotide binding]; other site 320373002810 salt bridge; other site 320373002811 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373002812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373002813 S-adenosylmethionine binding site [chemical binding]; other site 320373002814 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 320373002815 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 320373002816 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 320373002817 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 320373002818 domain interfaces; other site 320373002819 active site 320373002820 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 320373002821 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 320373002822 active site 320373002823 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 320373002824 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 320373002825 HemY protein N-terminus; Region: HemY_N; pfam07219 320373002826 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 320373002827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373002828 putative substrate translocation pore; other site 320373002829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373002830 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 320373002831 NAD(P) binding site [chemical binding]; other site 320373002832 active site 320373002833 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320373002834 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 320373002835 NAD(P) binding site [chemical binding]; other site 320373002836 catalytic residues [active] 320373002837 catalytic residues [active] 320373002838 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 320373002839 dimer interface [polypeptide binding]; other site 320373002840 substrate binding site [chemical binding]; other site 320373002841 metal binding sites [ion binding]; metal-binding site 320373002842 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 320373002843 GIY-YIG motif/motif A; other site 320373002844 putative active site [active] 320373002845 putative metal binding site [ion binding]; other site 320373002846 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 320373002847 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 320373002848 Protein of unknown function, DUF482; Region: DUF482; pfam04339 320373002849 NAD synthetase; Provisional; Region: PRK13981 320373002850 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 320373002851 multimer interface [polypeptide binding]; other site 320373002852 active site 320373002853 catalytic triad [active] 320373002854 protein interface 1 [polypeptide binding]; other site 320373002855 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 320373002856 homodimer interface [polypeptide binding]; other site 320373002857 NAD binding pocket [chemical binding]; other site 320373002858 ATP binding pocket [chemical binding]; other site 320373002859 Mg binding site [ion binding]; other site 320373002860 active-site loop [active] 320373002861 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 320373002862 Nitrogen regulatory protein P-II; Region: P-II; smart00938 320373002863 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373002864 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373002865 trimer interface [polypeptide binding]; other site 320373002866 eyelet of channel; other site 320373002867 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 320373002868 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320373002869 Walker A/P-loop; other site 320373002870 ATP binding site [chemical binding]; other site 320373002871 Q-loop/lid; other site 320373002872 ABC transporter signature motif; other site 320373002873 Walker B; other site 320373002874 D-loop; other site 320373002875 H-loop/switch region; other site 320373002876 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320373002877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373002878 dimer interface [polypeptide binding]; other site 320373002879 conserved gate region; other site 320373002880 putative PBP binding loops; other site 320373002881 ABC-ATPase subunit interface; other site 320373002882 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320373002883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373002884 dimer interface [polypeptide binding]; other site 320373002885 conserved gate region; other site 320373002886 putative PBP binding loops; other site 320373002887 ABC-ATPase subunit interface; other site 320373002888 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 320373002889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373002890 substrate binding pocket [chemical binding]; other site 320373002891 membrane-bound complex binding site; other site 320373002892 hinge residues; other site 320373002893 Pirin-related protein [General function prediction only]; Region: COG1741 320373002894 Pirin; Region: Pirin; pfam02678 320373002895 osmolarity response regulator; Provisional; Region: ompR; PRK09468 320373002896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373002897 active site 320373002898 phosphorylation site [posttranslational modification] 320373002899 intermolecular recognition site; other site 320373002900 dimerization interface [polypeptide binding]; other site 320373002901 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373002902 DNA binding site [nucleotide binding] 320373002903 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 320373002904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373002905 dimer interface [polypeptide binding]; other site 320373002906 phosphorylation site [posttranslational modification] 320373002907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373002908 ATP binding site [chemical binding]; other site 320373002909 Mg2+ binding site [ion binding]; other site 320373002910 G-X-G motif; other site 320373002911 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 320373002912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373002913 dimer interface [polypeptide binding]; other site 320373002914 conserved gate region; other site 320373002915 putative PBP binding loops; other site 320373002916 ABC-ATPase subunit interface; other site 320373002917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373002918 dimer interface [polypeptide binding]; other site 320373002919 conserved gate region; other site 320373002920 putative PBP binding loops; other site 320373002921 ABC-ATPase subunit interface; other site 320373002922 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 320373002923 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320373002924 Walker A/P-loop; other site 320373002925 ATP binding site [chemical binding]; other site 320373002926 Q-loop/lid; other site 320373002927 ABC transporter signature motif; other site 320373002928 Walker B; other site 320373002929 D-loop; other site 320373002930 H-loop/switch region; other site 320373002931 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 320373002932 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 320373002933 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 320373002934 active site 320373002935 homotetramer interface [polypeptide binding]; other site 320373002936 Predicted ATPase [General function prediction only]; Region: COG3911 320373002937 AAA domain; Region: AAA_28; pfam13521 320373002938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373002939 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373002940 putative substrate translocation pore; other site 320373002941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373002942 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 320373002943 substrate binding site [chemical binding]; other site 320373002944 ecotin; Provisional; Region: PRK03719 320373002945 secondary substrate binding site; other site 320373002946 primary substrate binding site; other site 320373002947 inhibition loop; other site 320373002948 dimerization interface [polypeptide binding]; other site 320373002949 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320373002950 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 320373002951 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 320373002952 haemagglutination activity domain; Region: Haemagg_act; pfam05860 320373002953 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 320373002954 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 320373002955 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 320373002956 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 320373002957 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 320373002958 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 320373002959 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 320373002960 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 320373002961 rRNA binding site [nucleotide binding]; other site 320373002962 predicted 30S ribosome binding site; other site 320373002963 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373002964 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373002965 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 320373002966 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 320373002967 Rubredoxin; Region: Rubredoxin; pfam00301 320373002968 iron binding site [ion binding]; other site 320373002969 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 320373002970 ABC transporter ATPase component; Reviewed; Region: PRK11147 320373002971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373002972 Walker A/P-loop; other site 320373002973 ATP binding site [chemical binding]; other site 320373002974 Q-loop/lid; other site 320373002975 ABC transporter signature motif; other site 320373002976 Walker B; other site 320373002977 D-loop; other site 320373002978 H-loop/switch region; other site 320373002979 ABC transporter; Region: ABC_tran_2; pfam12848 320373002980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320373002981 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 320373002982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373002983 ATP binding site [chemical binding]; other site 320373002984 Mg2+ binding site [ion binding]; other site 320373002985 G-X-G motif; other site 320373002986 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 320373002987 anchoring element; other site 320373002988 dimer interface [polypeptide binding]; other site 320373002989 ATP binding site [chemical binding]; other site 320373002990 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 320373002991 active site 320373002992 metal binding site [ion binding]; metal-binding site 320373002993 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 320373002994 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 320373002995 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 320373002996 CAP-like domain; other site 320373002997 active site 320373002998 primary dimer interface [polypeptide binding]; other site 320373002999 Predicted integral membrane protein [Function unknown]; Region: COG5615 320373003000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373003001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373003002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373003003 dimerization interface [polypeptide binding]; other site 320373003004 Predicted membrane protein [Function unknown]; Region: COG4125 320373003005 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 320373003006 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 320373003007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373003008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373003009 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373003010 dimerization interface [polypeptide binding]; other site 320373003011 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373003012 allantoate amidohydrolase; Reviewed; Region: PRK12893 320373003013 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 320373003014 active site 320373003015 metal binding site [ion binding]; metal-binding site 320373003016 dimer interface [polypeptide binding]; other site 320373003017 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320373003018 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 320373003019 active site 320373003020 Zn binding site [ion binding]; other site 320373003021 Chromate transporter; Region: Chromate_transp; pfam02417 320373003022 Chromate transporter; Region: Chromate_transp; pfam02417 320373003023 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320373003024 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373003025 metal binding site [ion binding]; metal-binding site 320373003026 active site 320373003027 I-site; other site 320373003028 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373003029 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 320373003030 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 320373003031 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 320373003032 homotrimer interaction site [polypeptide binding]; other site 320373003033 putative active site [active] 320373003034 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 320373003035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373003036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373003037 homodimer interface [polypeptide binding]; other site 320373003038 catalytic residue [active] 320373003039 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320373003040 EamA-like transporter family; Region: EamA; pfam00892 320373003041 EamA-like transporter family; Region: EamA; pfam00892 320373003042 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 320373003043 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373003044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373003045 DNA-binding site [nucleotide binding]; DNA binding site 320373003046 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373003047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373003048 homodimer interface [polypeptide binding]; other site 320373003049 catalytic residue [active] 320373003050 heat shock protein 90; Provisional; Region: PRK05218 320373003051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373003052 ATP binding site [chemical binding]; other site 320373003053 Mg2+ binding site [ion binding]; other site 320373003054 G-X-G motif; other site 320373003055 Chorismate lyase; Region: Chor_lyase; cl01230 320373003056 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 320373003057 putative active site [active] 320373003058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320373003059 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 320373003060 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 320373003061 Na binding site [ion binding]; other site 320373003062 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 320373003063 dimer interface [polypeptide binding]; other site 320373003064 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373003065 transaldolase-like protein; Provisional; Region: PTZ00411 320373003066 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 320373003067 active site 320373003068 dimer interface [polypeptide binding]; other site 320373003069 catalytic residue [active] 320373003070 Benzoate membrane transport protein; Region: BenE; pfam03594 320373003071 benzoate transporter; Region: benE; TIGR00843 320373003072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 320373003073 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320373003074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373003075 Walker A motif; other site 320373003076 ATP binding site [chemical binding]; other site 320373003077 Walker B motif; other site 320373003078 arginine finger; other site 320373003079 Cytochrome c553 [Energy production and conversion]; Region: COG2863 320373003080 Cytochrome c; Region: Cytochrom_C; cl11414 320373003081 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 320373003082 EamA-like transporter family; Region: EamA; pfam00892 320373003083 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 320373003084 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 320373003085 minor groove reading motif; other site 320373003086 helix-hairpin-helix signature motif; other site 320373003087 substrate binding pocket [chemical binding]; other site 320373003088 active site 320373003089 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 320373003090 ferredoxin; Provisional; Region: PRK06991 320373003091 Putative Fe-S cluster; Region: FeS; pfam04060 320373003092 4Fe-4S binding domain; Region: Fer4; pfam00037 320373003093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373003094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373003095 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 320373003096 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 320373003097 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 320373003098 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 320373003099 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 320373003100 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 320373003101 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 320373003102 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 320373003103 META domain; Region: META; pfam03724 320373003104 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 320373003105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373003106 ATP-grasp domain; Region: ATP-grasp; pfam02222 320373003107 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 320373003108 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 320373003109 DEAD-like helicases superfamily; Region: DEXDc; smart00487 320373003110 ATP binding site [chemical binding]; other site 320373003111 Mg++ binding site [ion binding]; other site 320373003112 motif III; other site 320373003113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373003114 nucleotide binding region [chemical binding]; other site 320373003115 ATP-binding site [chemical binding]; other site 320373003116 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 320373003117 active site 320373003118 HIGH motif; other site 320373003119 nucleotide binding site [chemical binding]; other site 320373003120 KMSKS motif; other site 320373003121 rhodanese superfamily protein; Provisional; Region: PRK05320 320373003122 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 320373003123 active site residue [active] 320373003124 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 320373003125 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 320373003126 putative active site [active] 320373003127 putative PHP Thumb interface [polypeptide binding]; other site 320373003128 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 320373003129 generic binding surface II; other site 320373003130 generic binding surface I; other site 320373003131 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 320373003132 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320373003133 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 320373003134 Walker A/P-loop; other site 320373003135 ATP binding site [chemical binding]; other site 320373003136 Q-loop/lid; other site 320373003137 ABC transporter signature motif; other site 320373003138 Walker B; other site 320373003139 D-loop; other site 320373003140 H-loop/switch region; other site 320373003141 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 320373003142 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 320373003143 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320373003144 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373003145 putative active site [active] 320373003146 O-Antigen ligase; Region: Wzy_C; cl04850 320373003147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373003148 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 320373003149 putative ADP-binding pocket [chemical binding]; other site 320373003150 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320373003151 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373003152 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373003153 putative active site [active] 320373003154 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 320373003155 putative metal binding site; other site 320373003156 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 320373003157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373003158 Uncharacterized conserved protein [Function unknown]; Region: COG2128 320373003159 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 320373003160 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 320373003161 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373003162 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373003163 DNA binding residues [nucleotide binding] 320373003164 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 320373003165 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 320373003166 Pectinacetylesterase; Region: PAE; pfam03283 320373003167 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 320373003168 ribonuclease G; Provisional; Region: PRK11712 320373003169 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 320373003170 homodimer interface [polypeptide binding]; other site 320373003171 oligonucleotide binding site [chemical binding]; other site 320373003172 Maf-like protein; Region: Maf; pfam02545 320373003173 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 320373003174 active site 320373003175 dimer interface [polypeptide binding]; other site 320373003176 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 320373003177 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 320373003178 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 320373003179 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 320373003180 active site 320373003181 (T/H)XGH motif; other site 320373003182 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 320373003183 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 320373003184 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 320373003185 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 320373003186 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 320373003187 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 320373003188 hypothetical protein; Validated; Region: PRK00110 320373003189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373003190 active site 320373003191 short chain dehydrogenase; Provisional; Region: PRK08339 320373003192 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 320373003193 putative NAD(P) binding site [chemical binding]; other site 320373003194 putative active site [active] 320373003195 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 320373003196 active site 320373003197 dimer interfaces [polypeptide binding]; other site 320373003198 catalytic residues [active] 320373003199 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 320373003200 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 320373003201 NADP binding site [chemical binding]; other site 320373003202 dimer interface [polypeptide binding]; other site 320373003203 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 320373003204 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 320373003205 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320373003206 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 320373003207 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 320373003208 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 320373003209 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 320373003210 Ligand Binding Site [chemical binding]; other site 320373003211 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 320373003212 GAF domain; Region: GAF_3; pfam13492 320373003213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373003214 dimer interface [polypeptide binding]; other site 320373003215 phosphorylation site [posttranslational modification] 320373003216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373003217 ATP binding site [chemical binding]; other site 320373003218 Mg2+ binding site [ion binding]; other site 320373003219 G-X-G motif; other site 320373003220 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 320373003221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373003222 active site 320373003223 phosphorylation site [posttranslational modification] 320373003224 intermolecular recognition site; other site 320373003225 dimerization interface [polypeptide binding]; other site 320373003226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373003227 DNA binding site [nucleotide binding] 320373003228 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 320373003229 Domain of unknown function (DUF333); Region: DUF333; pfam03891 320373003230 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 320373003231 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 320373003232 FtsX-like permease family; Region: FtsX; pfam02687 320373003233 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 320373003234 apolar tunnel; other site 320373003235 heme binding site [chemical binding]; other site 320373003236 dimerization interface [polypeptide binding]; other site 320373003237 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 320373003238 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 320373003239 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 320373003240 amidase; Provisional; Region: PRK07042 320373003241 Amidase; Region: Amidase; cl11426 320373003242 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373003243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373003244 putative substrate translocation pore; other site 320373003245 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 320373003246 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 320373003247 glucose-1-dehydrogenase; Provisional; Region: PRK06947 320373003248 classical (c) SDRs; Region: SDR_c; cd05233 320373003249 NAD(P) binding site [chemical binding]; other site 320373003250 active site 320373003251 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 320373003252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373003253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373003254 Bacterial transcriptional repressor; Region: TetR; pfam13972 320373003255 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 320373003256 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373003257 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 320373003258 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320373003259 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 320373003260 putative active site [active] 320373003261 putative metal binding site [ion binding]; other site 320373003262 RDD family; Region: RDD; pfam06271 320373003263 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 320373003264 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 320373003265 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373003266 RNA polymerase factor sigma-70; Validated; Region: PRK09047 320373003267 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373003268 DNA binding residues [nucleotide binding] 320373003269 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 320373003270 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373003271 PYR/PP interface [polypeptide binding]; other site 320373003272 dimer interface [polypeptide binding]; other site 320373003273 TPP binding site [chemical binding]; other site 320373003274 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373003275 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 320373003276 TPP-binding site [chemical binding]; other site 320373003277 dimer interface [polypeptide binding]; other site 320373003278 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 320373003279 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 320373003280 putative valine binding site [chemical binding]; other site 320373003281 dimer interface [polypeptide binding]; other site 320373003282 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 320373003283 ketol-acid reductoisomerase; Provisional; Region: PRK05479 320373003284 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 320373003285 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 320373003286 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 320373003287 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 320373003288 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 320373003289 2-isopropylmalate synthase; Validated; Region: PRK00915 320373003290 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 320373003291 active site 320373003292 catalytic residues [active] 320373003293 metal binding site [ion binding]; metal-binding site 320373003294 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 320373003295 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 320373003296 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 320373003297 Sulfate transporter family; Region: Sulfate_transp; pfam00916 320373003298 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 320373003299 active site clefts [active] 320373003300 zinc binding site [ion binding]; other site 320373003301 dimer interface [polypeptide binding]; other site 320373003302 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 320373003303 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 320373003304 putative ligand binding site [chemical binding]; other site 320373003305 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 320373003306 16S/18S rRNA binding site [nucleotide binding]; other site 320373003307 S13e-L30e interaction site [polypeptide binding]; other site 320373003308 25S rRNA binding site [nucleotide binding]; other site 320373003309 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 320373003310 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 320373003311 RNase E interface [polypeptide binding]; other site 320373003312 trimer interface [polypeptide binding]; other site 320373003313 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 320373003314 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 320373003315 RNase E interface [polypeptide binding]; other site 320373003316 trimer interface [polypeptide binding]; other site 320373003317 active site 320373003318 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 320373003319 putative nucleic acid binding region [nucleotide binding]; other site 320373003320 G-X-X-G motif; other site 320373003321 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 320373003322 RNA binding site [nucleotide binding]; other site 320373003323 domain interface; other site 320373003324 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 320373003325 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 320373003326 NAD(P) binding site [chemical binding]; other site 320373003327 triosephosphate isomerase; Provisional; Region: PRK14567 320373003328 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 320373003329 substrate binding site [chemical binding]; other site 320373003330 dimer interface [polypeptide binding]; other site 320373003331 catalytic triad [active] 320373003332 Preprotein translocase SecG subunit; Region: SecG; pfam03840 320373003333 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 320373003334 NADH dehydrogenase subunit B; Validated; Region: PRK06411 320373003335 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 320373003336 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 320373003337 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 320373003338 NADH dehydrogenase subunit D; Validated; Region: PRK06075 320373003339 NADH dehydrogenase subunit E; Validated; Region: PRK07539 320373003340 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 320373003341 putative dimer interface [polypeptide binding]; other site 320373003342 [2Fe-2S] cluster binding site [ion binding]; other site 320373003343 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 320373003344 SLBB domain; Region: SLBB; pfam10531 320373003345 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 320373003346 NADH dehydrogenase subunit G; Validated; Region: PRK09129 320373003347 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373003348 catalytic loop [active] 320373003349 iron binding site [ion binding]; other site 320373003350 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 320373003351 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 320373003352 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 320373003353 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 320373003354 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 320373003355 4Fe-4S binding domain; Region: Fer4; cl02805 320373003356 4Fe-4S binding domain; Region: Fer4; pfam00037 320373003357 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 320373003358 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 320373003359 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 320373003360 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 320373003361 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 320373003362 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320373003363 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 320373003364 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320373003365 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 320373003366 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320373003367 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 320373003368 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 320373003369 dimer interface [polypeptide binding]; other site 320373003370 ADP-ribose binding site [chemical binding]; other site 320373003371 active site 320373003372 nudix motif; other site 320373003373 metal binding site [ion binding]; metal-binding site 320373003374 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 320373003375 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 320373003376 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 320373003377 FAD binding site [chemical binding]; other site 320373003378 substrate binding site [chemical binding]; other site 320373003379 catalytic base [active] 320373003380 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 320373003381 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 320373003382 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 320373003383 active site 320373003384 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 320373003385 putative active site [active] 320373003386 putative catalytic site [active] 320373003387 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 320373003388 putative active site [active] 320373003389 putative catalytic site [active] 320373003390 Right handed beta helix region; Region: Beta_helix; pfam13229 320373003391 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373003392 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 320373003393 FAD binding site [chemical binding]; other site 320373003394 substrate binding site [chemical binding]; other site 320373003395 catalytic base [active] 320373003396 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 320373003397 putative active site [active] 320373003398 putative substrate binding site [chemical binding]; other site 320373003399 ATP binding site [chemical binding]; other site 320373003400 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320373003401 catalytic core [active] 320373003402 enoyl-CoA hydratase; Provisional; Region: PRK07511 320373003403 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373003404 substrate binding site [chemical binding]; other site 320373003405 oxyanion hole (OAH) forming residues; other site 320373003406 trimer interface [polypeptide binding]; other site 320373003407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 320373003408 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320373003409 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 320373003410 C-terminal domain interface [polypeptide binding]; other site 320373003411 GSH binding site (G-site) [chemical binding]; other site 320373003412 dimer interface [polypeptide binding]; other site 320373003413 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 320373003414 putative N-terminal domain interface [polypeptide binding]; other site 320373003415 putative dimer interface [polypeptide binding]; other site 320373003416 putative substrate binding pocket (H-site) [chemical binding]; other site 320373003417 methionine aminotransferase; Validated; Region: PRK09082 320373003418 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373003419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373003420 homodimer interface [polypeptide binding]; other site 320373003421 catalytic residue [active] 320373003422 PIN domain; Region: PIN_3; pfam13470 320373003423 PIN domain; Region: PIN_3; cl17397 320373003424 hypothetical protein; Validated; Region: PRK02101 320373003425 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 320373003426 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 320373003427 putative active site [active] 320373003428 Zn binding site [ion binding]; other site 320373003429 Predicted membrane protein [Function unknown]; Region: COG3235 320373003430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373003431 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 320373003432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373003433 DNA binding residues [nucleotide binding] 320373003434 dimerization interface [polypeptide binding]; other site 320373003435 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 320373003436 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 320373003437 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 320373003438 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 320373003439 active site 320373003440 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320373003441 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 320373003442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373003443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373003444 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 320373003445 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 320373003446 ligand binding site [chemical binding]; other site 320373003447 NAD binding site [chemical binding]; other site 320373003448 tetramer interface [polypeptide binding]; other site 320373003449 catalytic site [active] 320373003450 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 320373003451 L-serine binding site [chemical binding]; other site 320373003452 ACT domain interface; other site 320373003453 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 320373003454 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 320373003455 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373003456 substrate binding pocket [chemical binding]; other site 320373003457 membrane-bound complex binding site; other site 320373003458 hinge residues; other site 320373003459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 320373003460 Histidine kinase; Region: HisKA_3; pfam07730 320373003461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373003462 ATP binding site [chemical binding]; other site 320373003463 Mg2+ binding site [ion binding]; other site 320373003464 G-X-G motif; other site 320373003465 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 320373003466 catalytic motif [active] 320373003467 Catalytic residue [active] 320373003468 Aspartyl protease; Region: Asp_protease_2; pfam13650 320373003469 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 320373003470 Cytochrome c; Region: Cytochrom_C; cl11414 320373003471 Cytochrome c; Region: Cytochrom_C; cl11414 320373003472 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373003473 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373003474 Cytochrome c; Region: Cytochrom_C; pfam00034 320373003475 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 320373003476 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320373003477 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 320373003478 Putative D-pathway homolog; other site 320373003479 Low-spin heme binding site [chemical binding]; other site 320373003480 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 320373003481 Subunit I/II interface [polypeptide binding]; other site 320373003482 Putative Q-pathway; other site 320373003483 Putative alternate electron transfer pathway; other site 320373003484 Putative water exit pathway; other site 320373003485 Binuclear center (active site) [active] 320373003486 Putative K-pathway homolog; other site 320373003487 Putative proton exit pathway; other site 320373003488 Subunit I/IIa interface [polypeptide binding]; other site 320373003489 Electron transfer pathway; other site 320373003490 Cytochrome c553 [Energy production and conversion]; Region: COG2863 320373003491 Cytochrome c; Region: Cytochrom_C; cl11414 320373003492 HDOD domain; Region: HDOD; pfam08668 320373003493 PAS domain; Region: PAS_9; pfam13426 320373003494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373003495 putative active site [active] 320373003496 heme pocket [chemical binding]; other site 320373003497 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373003498 metal binding site [ion binding]; metal-binding site 320373003499 active site 320373003500 I-site; other site 320373003501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373003502 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 320373003503 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 320373003504 catalytic triad [active] 320373003505 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 320373003506 NADH(P)-binding; Region: NAD_binding_10; pfam13460 320373003507 NAD(P) binding site [chemical binding]; other site 320373003508 putative active site [active] 320373003509 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 320373003510 Protein export membrane protein; Region: SecD_SecF; cl14618 320373003511 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 320373003512 Protein export membrane protein; Region: SecD_SecF; cl14618 320373003513 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 320373003514 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373003515 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373003516 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320373003517 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373003518 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373003519 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 320373003520 Predicted transcriptional regulator [Transcription]; Region: COG1959 320373003521 Transcriptional regulator; Region: Rrf2; pfam02082 320373003522 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 320373003523 NADH(P)-binding; Region: NAD_binding_10; pfam13460 320373003524 NAD binding site [chemical binding]; other site 320373003525 putative active site [active] 320373003526 substrate binding site [chemical binding]; other site 320373003527 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 320373003528 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373003529 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373003530 putative DNA binding site [nucleotide binding]; other site 320373003531 putative Zn2+ binding site [ion binding]; other site 320373003532 AsnC family; Region: AsnC_trans_reg; pfam01037 320373003533 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 320373003534 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 320373003535 Walker A/P-loop; other site 320373003536 ATP binding site [chemical binding]; other site 320373003537 Q-loop/lid; other site 320373003538 ABC transporter signature motif; other site 320373003539 Walker B; other site 320373003540 D-loop; other site 320373003541 H-loop/switch region; other site 320373003542 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 320373003543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373003544 dimer interface [polypeptide binding]; other site 320373003545 conserved gate region; other site 320373003546 putative PBP binding loops; other site 320373003547 ABC-ATPase subunit interface; other site 320373003548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373003549 ABC-ATPase subunit interface; other site 320373003550 putative PBP binding loops; other site 320373003551 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320373003552 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320373003553 putative proline-specific permease; Provisional; Region: proY; PRK10580 320373003554 Predicted membrane protein [Function unknown]; Region: COG1289 320373003555 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 320373003556 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 320373003557 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320373003558 trimer interface [polypeptide binding]; other site 320373003559 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 320373003560 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 320373003561 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 320373003562 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 320373003563 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 320373003564 Family description; Region: UvrD_C_2; pfam13538 320373003565 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 320373003566 AAA domain; Region: AAA_30; pfam13604 320373003567 Family description; Region: UvrD_C_2; pfam13538 320373003568 hypothetical protein; Provisional; Region: PRK09256 320373003569 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 320373003570 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373003571 EamA-like transporter family; Region: EamA; pfam00892 320373003572 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 320373003573 EamA-like transporter family; Region: EamA; pfam00892 320373003574 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 320373003575 ThiC-associated domain; Region: ThiC-associated; pfam13667 320373003576 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 320373003577 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 320373003578 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 320373003579 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 320373003580 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 320373003581 Moco binding site; other site 320373003582 metal coordination site [ion binding]; other site 320373003583 EamA-like transporter family; Region: EamA; pfam00892 320373003584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373003585 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320373003586 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 320373003587 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320373003588 active site 320373003589 metal binding site [ion binding]; metal-binding site 320373003590 hexamer interface [polypeptide binding]; other site 320373003591 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 320373003592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373003593 Walker A/P-loop; other site 320373003594 ATP binding site [chemical binding]; other site 320373003595 Q-loop/lid; other site 320373003596 ABC transporter signature motif; other site 320373003597 Walker B; other site 320373003598 D-loop; other site 320373003599 H-loop/switch region; other site 320373003600 TOBE domain; Region: TOBE_2; pfam08402 320373003601 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 320373003602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373003603 putative PBP binding loops; other site 320373003604 ABC-ATPase subunit interface; other site 320373003605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 320373003606 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320373003607 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320373003608 Transcriptional regulators [Transcription]; Region: PurR; COG1609 320373003609 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 320373003610 DNA binding site [nucleotide binding] 320373003611 domain linker motif; other site 320373003612 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 320373003613 putative dimerization interface [polypeptide binding]; other site 320373003614 putative ligand binding site [chemical binding]; other site 320373003615 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 320373003616 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320373003617 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373003618 metal binding site [ion binding]; metal-binding site 320373003619 active site 320373003620 I-site; other site 320373003621 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 320373003622 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 320373003623 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 320373003624 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 320373003625 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373003626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373003627 DNA-binding site [nucleotide binding]; DNA binding site 320373003628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373003629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373003630 homodimer interface [polypeptide binding]; other site 320373003631 catalytic residue [active] 320373003632 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373003633 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373003634 putative DNA binding site [nucleotide binding]; other site 320373003635 putative Zn2+ binding site [ion binding]; other site 320373003636 AsnC family; Region: AsnC_trans_reg; pfam01037 320373003637 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 320373003638 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 320373003639 glutaminase active site [active] 320373003640 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 320373003641 dimer interface [polypeptide binding]; other site 320373003642 active site 320373003643 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 320373003644 dimer interface [polypeptide binding]; other site 320373003645 active site 320373003646 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 320373003647 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 320373003648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373003649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373003650 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 320373003651 putative effector binding pocket; other site 320373003652 putative dimerization interface [polypeptide binding]; other site 320373003653 short chain dehydrogenase; Provisional; Region: PRK12744 320373003654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373003655 NAD(P) binding site [chemical binding]; other site 320373003656 active site 320373003657 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 320373003658 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 320373003659 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 320373003660 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320373003661 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320373003662 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 320373003663 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373003664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373003665 DNA-binding site [nucleotide binding]; DNA binding site 320373003666 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373003667 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373003668 homodimer interface [polypeptide binding]; other site 320373003669 catalytic residue [active] 320373003670 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320373003671 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 320373003672 putative dimer interface [polypeptide binding]; other site 320373003673 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320373003674 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 320373003675 putative dimer interface [polypeptide binding]; other site 320373003676 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 320373003677 active site 320373003678 substrate-binding site [chemical binding]; other site 320373003679 metal-binding site [ion binding] 320373003680 GTP binding site [chemical binding]; other site 320373003681 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 320373003682 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320373003683 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320373003684 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373003685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373003686 LysR substrate binding domain; Region: LysR_substrate; pfam03466 320373003687 dimerization interface [polypeptide binding]; other site 320373003688 Malonate transporter MadL subunit; Region: MadL; cl04273 320373003689 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 320373003690 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 320373003691 Coenzyme A transferase; Region: CoA_trans; cl17247 320373003692 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 320373003693 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 320373003694 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 320373003695 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 320373003696 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 320373003697 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 320373003698 Acyl transferase domain; Region: Acyl_transf_1; cl08282 320373003699 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 320373003700 putative active site [active] 320373003701 catalytic site [active] 320373003702 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 320373003703 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320373003704 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 320373003705 C-terminal domain interface [polypeptide binding]; other site 320373003706 GSH binding site (G-site) [chemical binding]; other site 320373003707 dimer interface [polypeptide binding]; other site 320373003708 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 320373003709 N-terminal domain interface [polypeptide binding]; other site 320373003710 proline/glycine betaine transporter; Provisional; Region: PRK10642 320373003711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373003712 putative substrate translocation pore; other site 320373003713 hypothetical protein; Provisional; Region: PRK02237 320373003714 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 320373003715 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 320373003716 active site 320373003717 catalytic site [active] 320373003718 substrate binding site [chemical binding]; other site 320373003719 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 320373003720 RNA/DNA hybrid binding site [nucleotide binding]; other site 320373003721 active site 320373003722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373003723 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 320373003724 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 320373003725 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320373003726 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320373003727 catalytic residue [active] 320373003728 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 320373003729 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320373003730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373003731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373003732 putative substrate translocation pore; other site 320373003733 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 320373003734 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373003735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373003736 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 320373003737 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 320373003738 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 320373003739 catalytic site [active] 320373003740 subunit interface [polypeptide binding]; other site 320373003741 leucine export protein LeuE; Provisional; Region: PRK10958 320373003742 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 320373003743 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320373003744 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 320373003745 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 320373003746 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320373003747 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320373003748 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 320373003749 IMP binding site; other site 320373003750 dimer interface [polypeptide binding]; other site 320373003751 interdomain contacts; other site 320373003752 partial ornithine binding site; other site 320373003753 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 320373003754 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 320373003755 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 320373003756 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 320373003757 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 320373003758 FtsJ-like methyltransferase; Region: FtsJ; cl17430 320373003759 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 320373003760 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 320373003761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373003762 Walker A motif; other site 320373003763 ATP binding site [chemical binding]; other site 320373003764 Walker B motif; other site 320373003765 arginine finger; other site 320373003766 Peptidase family M41; Region: Peptidase_M41; pfam01434 320373003767 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 320373003768 dihydropteroate synthase; Region: DHPS; TIGR01496 320373003769 substrate binding pocket [chemical binding]; other site 320373003770 dimer interface [polypeptide binding]; other site 320373003771 inhibitor binding site; inhibition site 320373003772 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 320373003773 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 320373003774 active site 320373003775 substrate binding site [chemical binding]; other site 320373003776 metal binding site [ion binding]; metal-binding site 320373003777 PBP superfamily domain; Region: PBP_like_2; cl17296 320373003778 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 320373003779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373003780 dimer interface [polypeptide binding]; other site 320373003781 conserved gate region; other site 320373003782 putative PBP binding loops; other site 320373003783 ABC-ATPase subunit interface; other site 320373003784 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 320373003785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373003786 dimer interface [polypeptide binding]; other site 320373003787 conserved gate region; other site 320373003788 putative PBP binding loops; other site 320373003789 ABC-ATPase subunit interface; other site 320373003790 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 320373003791 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 320373003792 Walker A/P-loop; other site 320373003793 ATP binding site [chemical binding]; other site 320373003794 Q-loop/lid; other site 320373003795 ABC transporter signature motif; other site 320373003796 Walker B; other site 320373003797 D-loop; other site 320373003798 H-loop/switch region; other site 320373003799 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 320373003800 PhoU domain; Region: PhoU; pfam01895 320373003801 PhoU domain; Region: PhoU; pfam01895 320373003802 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 320373003803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373003804 active site 320373003805 phosphorylation site [posttranslational modification] 320373003806 intermolecular recognition site; other site 320373003807 dimerization interface [polypeptide binding]; other site 320373003808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373003809 DNA binding site [nucleotide binding] 320373003810 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 320373003811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373003812 dimer interface [polypeptide binding]; other site 320373003813 phosphorylation site [posttranslational modification] 320373003814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373003815 ATP binding site [chemical binding]; other site 320373003816 Mg2+ binding site [ion binding]; other site 320373003817 G-X-G motif; other site 320373003818 polyphosphate kinase; Provisional; Region: PRK05443 320373003819 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 320373003820 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 320373003821 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 320373003822 putative active site [active] 320373003823 catalytic site [active] 320373003824 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 320373003825 putative domain interface [polypeptide binding]; other site 320373003826 putative active site [active] 320373003827 catalytic site [active] 320373003828 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 320373003829 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 320373003830 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 320373003831 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 320373003832 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 320373003833 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 320373003834 catalytic core [active] 320373003835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 320373003836 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 320373003837 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 320373003838 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 320373003839 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 320373003840 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 320373003841 active site 320373003842 acyl-activating enzyme (AAE) consensus motif; other site 320373003843 putative CoA binding site [chemical binding]; other site 320373003844 AMP binding site [chemical binding]; other site 320373003845 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320373003846 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 320373003847 Peptidase family M23; Region: Peptidase_M23; pfam01551 320373003848 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 320373003849 active site 320373003850 catalytic residues [active] 320373003851 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 320373003852 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 320373003853 Phage-related minor tail protein [Function unknown]; Region: COG5281 320373003854 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 320373003855 integrase; Provisional; Region: int; PHA02601 320373003856 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373003857 active site 320373003858 DNA binding site [nucleotide binding] 320373003859 Int/Topo IB signature motif; other site 320373003860 Transposase domain (DUF772); Region: DUF772; pfam05598 320373003861 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320373003862 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320373003863 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373003864 DNA binding site [nucleotide binding] 320373003865 active site 320373003866 Int/Topo IB signature motif; other site 320373003867 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 320373003868 PAAR motif; Region: PAAR_motif; pfam05488 320373003869 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 320373003870 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 320373003871 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 320373003872 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 320373003873 Leucine carboxyl methyltransferase; Region: LCM; cl01306 320373003874 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373003875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373003876 DNA-binding site [nucleotide binding]; DNA binding site 320373003877 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373003878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373003879 homodimer interface [polypeptide binding]; other site 320373003880 catalytic residue [active] 320373003881 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 320373003882 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 320373003883 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 320373003884 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 320373003885 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 320373003886 active site 320373003887 catalytic site [active] 320373003888 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 320373003889 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 320373003890 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 320373003891 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 320373003892 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 320373003893 catalytic site [active] 320373003894 active site 320373003895 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 320373003896 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 320373003897 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 320373003898 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 320373003899 active site 320373003900 catalytic site [active] 320373003901 glycogen branching enzyme; Provisional; Region: PRK05402 320373003902 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 320373003903 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 320373003904 active site 320373003905 catalytic site [active] 320373003906 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 320373003907 trehalose synthase; Region: treS_nterm; TIGR02456 320373003908 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 320373003909 active site 320373003910 catalytic site [active] 320373003911 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 320373003912 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 320373003913 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 320373003914 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 320373003915 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 320373003916 active site 320373003917 homodimer interface [polypeptide binding]; other site 320373003918 catalytic site [active] 320373003919 acceptor binding site [chemical binding]; other site 320373003920 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 320373003921 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 320373003922 Interdomain contacts; other site 320373003923 Cytokine receptor motif; other site 320373003924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373003925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373003926 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373003927 dimerization interface [polypeptide binding]; other site 320373003928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373003929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373003930 active site 320373003931 phosphorylation site [posttranslational modification] 320373003932 intermolecular recognition site; other site 320373003933 dimerization interface [polypeptide binding]; other site 320373003934 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373003935 DNA binding site [nucleotide binding] 320373003936 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 320373003937 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 320373003938 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 320373003939 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373003940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373003941 active site 320373003942 phosphorylation site [posttranslational modification] 320373003943 intermolecular recognition site; other site 320373003944 dimerization interface [polypeptide binding]; other site 320373003945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373003946 DNA binding site [nucleotide binding] 320373003947 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 320373003948 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320373003949 trimer interface [polypeptide binding]; other site 320373003950 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 320373003951 trimer interface [polypeptide binding]; other site 320373003952 YadA-like C-terminal region; Region: YadA; pfam03895 320373003953 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373003954 ligand binding site [chemical binding]; other site 320373003955 TPR repeat; Region: TPR_11; pfam13414 320373003956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373003957 binding surface 320373003958 TPR motif; other site 320373003959 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 320373003960 H-NS histone family; Region: Histone_HNS; pfam00816 320373003961 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373003962 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 320373003963 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320373003964 Cu(I) binding site [ion binding]; other site 320373003965 Ricin-type beta-trefoil; Region: RICIN; smart00458 320373003966 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 320373003967 putative sugar binding sites [chemical binding]; other site 320373003968 Q-X-W motif; other site 320373003969 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 320373003970 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 320373003971 Galactose oxidase, central domain; Region: Kelch_3; cl02701 320373003972 Kelch motif; Region: Kelch_6; pfam13964 320373003973 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 320373003974 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 320373003975 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320373003976 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 320373003977 PAAR motif; Region: PAAR_motif; pfam05488 320373003978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 320373003979 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373003980 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373003981 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 320373003982 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 320373003983 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 320373003984 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 320373003985 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 320373003986 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 320373003987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 320373003988 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373003989 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373003990 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 320373003991 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 320373003992 Pleckstrin homology-like domain; Region: PH-like; cl17171 320373003993 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320373003994 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373003995 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373003996 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 320373003997 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 320373003998 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 320373003999 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 320373004000 Integrase core domain; Region: rve; pfam00665 320373004001 Integrase core domain; Region: rve_3; pfam13683 320373004002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 320373004003 H-NS histone family; Region: Histone_HNS; pfam00816 320373004004 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373004005 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 320373004006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320373004007 active site 320373004008 benzoate transport; Region: 2A0115; TIGR00895 320373004009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373004010 putative substrate translocation pore; other site 320373004011 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 320373004012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373004013 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 320373004014 dimerization interface [polypeptide binding]; other site 320373004015 substrate binding pocket [chemical binding]; other site 320373004016 Spore Coat Protein U domain; Region: SCPU; pfam05229 320373004017 Spore Coat Protein U domain; Region: SCPU; pfam05229 320373004018 Spore Coat Protein U domain; Region: SCPU; pfam05229 320373004019 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 320373004020 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 320373004021 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 320373004022 PapC N-terminal domain; Region: PapC_N; pfam13954 320373004023 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 320373004024 PapC C-terminal domain; Region: PapC_C; pfam13953 320373004025 Spore Coat Protein U domain; Region: SCPU; pfam05229 320373004026 Spore Coat Protein U domain; Region: SCPU; pfam05229 320373004027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373004028 dimer interface [polypeptide binding]; other site 320373004029 phosphorylation site [posttranslational modification] 320373004030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373004031 ATP binding site [chemical binding]; other site 320373004032 Mg2+ binding site [ion binding]; other site 320373004033 G-X-G motif; other site 320373004034 Response regulator receiver domain; Region: Response_reg; pfam00072 320373004035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373004036 active site 320373004037 phosphorylation site [posttranslational modification] 320373004038 intermolecular recognition site; other site 320373004039 dimerization interface [polypeptide binding]; other site 320373004040 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373004041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373004042 active site 320373004043 phosphorylation site [posttranslational modification] 320373004044 intermolecular recognition site; other site 320373004045 dimerization interface [polypeptide binding]; other site 320373004046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373004047 DNA binding residues [nucleotide binding] 320373004048 dimerization interface [polypeptide binding]; other site 320373004049 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 320373004050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373004051 S-adenosylmethionine binding site [chemical binding]; other site 320373004052 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373004053 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320373004054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373004055 putative substrate translocation pore; other site 320373004056 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 320373004057 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373004058 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373004059 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 320373004060 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 320373004061 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 320373004062 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 320373004063 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 320373004064 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 320373004065 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 320373004066 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 320373004067 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 320373004068 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 320373004069 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 320373004070 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 320373004071 nudix motif; other site 320373004072 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 320373004073 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320373004074 active site 320373004075 HIGH motif; other site 320373004076 nucleotide binding site [chemical binding]; other site 320373004077 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 320373004078 KMSKS motif; other site 320373004079 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 320373004080 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320373004081 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320373004082 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 320373004083 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 320373004084 motif 1; other site 320373004085 active site 320373004086 motif 2; other site 320373004087 motif 3; other site 320373004088 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 320373004089 DHHA1 domain; Region: DHHA1; pfam02272 320373004090 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373004091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373004092 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373004093 dimerization interface [polypeptide binding]; other site 320373004094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373004095 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 320373004096 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 320373004097 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320373004098 protein binding site [polypeptide binding]; other site 320373004099 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320373004100 protein binding site [polypeptide binding]; other site 320373004101 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 320373004102 nudix motif; other site 320373004103 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 320373004104 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 320373004105 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 320373004106 putative active site [active] 320373004107 metal binding site [ion binding]; metal-binding site 320373004108 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 320373004109 active site 320373004110 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320373004111 TM-ABC transporter signature motif; other site 320373004112 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320373004113 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320373004114 TM-ABC transporter signature motif; other site 320373004115 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320373004116 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320373004117 Walker A/P-loop; other site 320373004118 ATP binding site [chemical binding]; other site 320373004119 Q-loop/lid; other site 320373004120 ABC transporter signature motif; other site 320373004121 Walker B; other site 320373004122 D-loop; other site 320373004123 H-loop/switch region; other site 320373004124 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320373004125 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320373004126 Walker A/P-loop; other site 320373004127 ATP binding site [chemical binding]; other site 320373004128 Q-loop/lid; other site 320373004129 ABC transporter signature motif; other site 320373004130 Walker B; other site 320373004131 D-loop; other site 320373004132 H-loop/switch region; other site 320373004133 KduI/IolB family; Region: KduI; pfam04962 320373004134 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 320373004135 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 320373004136 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373004137 PYR/PP interface [polypeptide binding]; other site 320373004138 dimer interface [polypeptide binding]; other site 320373004139 TPP binding site [chemical binding]; other site 320373004140 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373004141 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 320373004142 TPP-binding site [chemical binding]; other site 320373004143 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320373004144 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 320373004145 substrate binding site [chemical binding]; other site 320373004146 ATP binding site [chemical binding]; other site 320373004147 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 320373004148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 320373004149 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320373004150 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320373004151 Walker A/P-loop; other site 320373004152 ATP binding site [chemical binding]; other site 320373004153 Q-loop/lid; other site 320373004154 ABC transporter signature motif; other site 320373004155 Walker B; other site 320373004156 D-loop; other site 320373004157 H-loop/switch region; other site 320373004158 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373004159 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373004160 TM-ABC transporter signature motif; other site 320373004161 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 320373004162 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320373004163 putative ligand binding site [chemical binding]; other site 320373004164 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320373004165 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320373004166 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320373004167 putative active site [active] 320373004168 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 320373004169 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 320373004170 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 320373004171 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 320373004172 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 320373004173 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 320373004174 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 320373004175 CPxP motif; other site 320373004176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373004177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373004178 active site 320373004179 phosphorylation site [posttranslational modification] 320373004180 intermolecular recognition site; other site 320373004181 dimerization interface [polypeptide binding]; other site 320373004182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373004183 DNA binding site [nucleotide binding] 320373004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 320373004185 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320373004186 FecR protein; Region: FecR; pfam04773 320373004187 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 320373004188 CHASE2 domain; Region: CHASE2; pfam05226 320373004189 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 320373004190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373004191 dimer interface [polypeptide binding]; other site 320373004192 phosphorylation site [posttranslational modification] 320373004193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373004194 ATP binding site [chemical binding]; other site 320373004195 Mg2+ binding site [ion binding]; other site 320373004196 G-X-G motif; other site 320373004197 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 320373004198 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 320373004199 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 320373004200 active site 320373004201 tetramer interface; other site 320373004202 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 320373004203 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 320373004204 HIGH motif; other site 320373004205 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 320373004206 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 320373004207 active site 320373004208 KMSKS motif; other site 320373004209 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 320373004210 tRNA binding surface [nucleotide binding]; other site 320373004211 anticodon binding site; other site 320373004212 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 320373004213 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 320373004214 Part of AAA domain; Region: AAA_19; pfam13245 320373004215 Family description; Region: UvrD_C_2; pfam13538 320373004216 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 320373004217 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 320373004218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373004219 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373004220 putative substrate translocation pore; other site 320373004221 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320373004222 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373004223 dimer interface [polypeptide binding]; other site 320373004224 putative CheW interface [polypeptide binding]; other site 320373004225 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 320373004226 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373004227 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373004228 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 320373004229 Fusaric acid resistance protein family; Region: FUSC; pfam04632 320373004230 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 320373004231 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373004232 transcriptional regulator; Provisional; Region: PRK10632 320373004233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373004234 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373004235 putative effector binding pocket; other site 320373004236 dimerization interface [polypeptide binding]; other site 320373004237 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320373004238 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320373004239 active site 320373004240 metal binding site [ion binding]; metal-binding site 320373004241 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320373004242 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320373004243 FAD binding domain; Region: FAD_binding_4; pfam01565 320373004244 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 320373004245 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 320373004246 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320373004247 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 320373004248 Protein of unknown function (DUF962); Region: DUF962; cl01879 320373004249 FOG: CBS domain [General function prediction only]; Region: COG0517 320373004250 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 320373004251 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 320373004252 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 320373004253 putative acyl-acceptor binding pocket; other site 320373004254 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 320373004255 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 320373004256 Tetramer interface [polypeptide binding]; other site 320373004257 active site 320373004258 FMN-binding site [chemical binding]; other site 320373004259 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 320373004260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320373004261 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 320373004262 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 320373004263 short chain dehydrogenase; Provisional; Region: PRK06949 320373004264 classical (c) SDRs; Region: SDR_c; cd05233 320373004265 NAD(P) binding site [chemical binding]; other site 320373004266 active site 320373004267 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 320373004268 active site 320373004269 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 320373004270 PAS domain; Region: PAS_9; pfam13426 320373004271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373004272 putative active site [active] 320373004273 heme pocket [chemical binding]; other site 320373004274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373004275 DNA binding residues [nucleotide binding] 320373004276 dimerization interface [polypeptide binding]; other site 320373004277 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 320373004278 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 320373004279 short chain dehydrogenase; Provisional; Region: PRK07041 320373004280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373004281 NAD(P) binding site [chemical binding]; other site 320373004282 active site 320373004283 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 320373004284 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 320373004285 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 320373004286 LysR family transcriptional regulator; Provisional; Region: PRK14997 320373004287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373004288 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373004289 putative effector binding pocket; other site 320373004290 dimerization interface [polypeptide binding]; other site 320373004291 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 320373004292 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 320373004293 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373004294 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373004295 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 320373004296 homotrimer interaction site [polypeptide binding]; other site 320373004297 putative active site [active] 320373004298 HD domain; Region: HD_4; pfam13328 320373004299 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 320373004300 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 320373004301 synthetase active site [active] 320373004302 NTP binding site [chemical binding]; other site 320373004303 metal binding site [ion binding]; metal-binding site 320373004304 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 320373004305 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 320373004306 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 320373004307 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 320373004308 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 320373004309 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 320373004310 active site 320373004311 dimer interface [polypeptide binding]; other site 320373004312 motif 1; other site 320373004313 motif 2; other site 320373004314 motif 3; other site 320373004315 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 320373004316 anticodon binding site; other site 320373004317 translation initiation factor IF-3; Region: infC; TIGR00168 320373004318 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 320373004319 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 320373004320 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 320373004321 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 320373004322 23S rRNA binding site [nucleotide binding]; other site 320373004323 L21 binding site [polypeptide binding]; other site 320373004324 L13 binding site [polypeptide binding]; other site 320373004325 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 320373004326 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 320373004327 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 320373004328 dimer interface [polypeptide binding]; other site 320373004329 motif 1; other site 320373004330 active site 320373004331 motif 2; other site 320373004332 motif 3; other site 320373004333 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 320373004334 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 320373004335 putative tRNA-binding site [nucleotide binding]; other site 320373004336 B3/4 domain; Region: B3_4; pfam03483 320373004337 tRNA synthetase B5 domain; Region: B5; smart00874 320373004338 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 320373004339 dimer interface [polypeptide binding]; other site 320373004340 motif 1; other site 320373004341 motif 3; other site 320373004342 motif 2; other site 320373004343 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 320373004344 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 320373004345 IHF dimer interface [polypeptide binding]; other site 320373004346 IHF - DNA interface [nucleotide binding]; other site 320373004347 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 320373004348 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 320373004349 DNA binding residues [nucleotide binding] 320373004350 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320373004351 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 320373004352 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 320373004353 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 320373004354 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 320373004355 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 320373004356 Transposase domain (DUF772); Region: DUF772; pfam05598 320373004357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320373004358 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320373004359 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 320373004360 outer membrane protein A; Reviewed; Region: PRK10808 320373004361 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 320373004362 Uncharacterized conserved protein [Function unknown]; Region: COG1434 320373004363 putative active site [active] 320373004364 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 320373004365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373004366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373004367 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 320373004368 putative dimerization interface [polypeptide binding]; other site 320373004369 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 320373004370 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 320373004371 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320373004372 RNA binding surface [nucleotide binding]; other site 320373004373 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 320373004374 probable active site [active] 320373004375 ribosome maturation protein RimP; Reviewed; Region: PRK00092 320373004376 Sm and related proteins; Region: Sm_like; cl00259 320373004377 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 320373004378 putative oligomer interface [polypeptide binding]; other site 320373004379 putative RNA binding site [nucleotide binding]; other site 320373004380 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 320373004381 NusA N-terminal domain; Region: NusA_N; pfam08529 320373004382 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 320373004383 RNA binding site [nucleotide binding]; other site 320373004384 homodimer interface [polypeptide binding]; other site 320373004385 NusA-like KH domain; Region: KH_5; pfam13184 320373004386 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 320373004387 G-X-X-G motif; other site 320373004388 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 320373004389 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 320373004390 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 320373004391 translation initiation factor IF-2; Region: IF-2; TIGR00487 320373004392 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 320373004393 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 320373004394 G1 box; other site 320373004395 putative GEF interaction site [polypeptide binding]; other site 320373004396 GTP/Mg2+ binding site [chemical binding]; other site 320373004397 Switch I region; other site 320373004398 G2 box; other site 320373004399 G3 box; other site 320373004400 Switch II region; other site 320373004401 G4 box; other site 320373004402 G5 box; other site 320373004403 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 320373004404 Translation-initiation factor 2; Region: IF-2; pfam11987 320373004405 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 320373004406 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 320373004407 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 320373004408 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 320373004409 RNA binding site [nucleotide binding]; other site 320373004410 active site 320373004411 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 320373004412 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320373004413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373004414 putative substrate translocation pore; other site 320373004415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373004416 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 320373004417 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373004418 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320373004419 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373004420 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320373004421 MarR family; Region: MarR_2; pfam12802 320373004422 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 320373004423 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 320373004424 G1 box; other site 320373004425 putative GEF interaction site [polypeptide binding]; other site 320373004426 GTP/Mg2+ binding site [chemical binding]; other site 320373004427 Switch I region; other site 320373004428 G2 box; other site 320373004429 G3 box; other site 320373004430 Switch II region; other site 320373004431 G4 box; other site 320373004432 G5 box; other site 320373004433 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 320373004434 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 320373004435 Transposase domain (DUF772); Region: DUF772; pfam05598 320373004436 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320373004437 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320373004438 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 320373004439 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 320373004440 TPP-binding site [chemical binding]; other site 320373004441 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 320373004442 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 320373004443 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320373004444 E3 interaction surface; other site 320373004445 lipoyl attachment site [posttranslational modification]; other site 320373004446 e3 binding domain; Region: E3_binding; pfam02817 320373004447 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 320373004448 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 320373004449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373004450 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320373004451 Predicted ATPase [General function prediction only]; Region: COG1485 320373004452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373004453 Walker B; other site 320373004454 D-loop; other site 320373004455 H-loop/switch region; other site 320373004456 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 320373004457 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 320373004458 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 320373004459 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 320373004460 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 320373004461 Flp/Fap pilin component; Region: Flp_Fap; cl01585 320373004462 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 320373004463 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 320373004464 TadE-like protein; Region: TadE; pfam07811 320373004465 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 320373004466 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 320373004467 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 320373004468 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373004469 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 320373004470 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 320373004471 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 320373004472 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 320373004473 ATP binding site [chemical binding]; other site 320373004474 Walker A motif; other site 320373004475 hexamer interface [polypeptide binding]; other site 320373004476 Walker B motif; other site 320373004477 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 320373004478 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373004479 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 320373004480 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373004481 TPR repeat; Region: TPR_11; pfam13414 320373004482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373004483 binding surface 320373004484 TPR motif; other site 320373004485 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 320373004486 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 320373004487 Predicted membrane protein [Function unknown]; Region: COG4655 320373004488 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 320373004489 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 320373004490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373004491 Walker A motif; other site 320373004492 ATP binding site [chemical binding]; other site 320373004493 Walker B motif; other site 320373004494 arginine finger; other site 320373004495 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373004496 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 320373004497 bacterial Hfq-like; Region: Hfq; cd01716 320373004498 hexamer interface [polypeptide binding]; other site 320373004499 Sm1 motif; other site 320373004500 RNA binding site [nucleotide binding]; other site 320373004501 Sm2 motif; other site 320373004502 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 320373004503 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 320373004504 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 320373004505 acyl-activating enzyme (AAE) consensus motif; other site 320373004506 putative AMP binding site [chemical binding]; other site 320373004507 putative active site [active] 320373004508 putative CoA binding site [chemical binding]; other site 320373004509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373004510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373004511 putative sialic acid transporter; Region: 2A0112; TIGR00891 320373004512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373004513 putative substrate translocation pore; other site 320373004514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 320373004515 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320373004516 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 320373004517 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 320373004518 Sulfate transporter family; Region: Sulfate_transp; pfam00916 320373004519 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 320373004520 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 320373004521 metal binding site [ion binding]; metal-binding site 320373004522 Phosphoesterase family; Region: Phosphoesterase; pfam04185 320373004523 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373004524 dimer interface [polypeptide binding]; other site 320373004525 putative CheW interface [polypeptide binding]; other site 320373004526 ribonuclease R; Region: RNase_R; TIGR02063 320373004527 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 320373004528 RNB domain; Region: RNB; pfam00773 320373004529 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320373004530 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 320373004531 RNA binding site [nucleotide binding]; other site 320373004532 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 320373004533 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 320373004534 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 320373004535 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 320373004536 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 320373004537 amidase catalytic site [active] 320373004538 Zn binding residues [ion binding]; other site 320373004539 substrate binding site [chemical binding]; other site 320373004540 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 320373004541 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 320373004542 tetramer (dimer of dimers) interface [polypeptide binding]; other site 320373004543 active site 320373004544 dimer interface [polypeptide binding]; other site 320373004545 Transcriptional regulators [Transcription]; Region: FadR; COG2186 320373004546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373004547 DNA-binding site [nucleotide binding]; DNA binding site 320373004548 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 320373004549 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 320373004550 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 320373004551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373004552 dimer interface [polypeptide binding]; other site 320373004553 conserved gate region; other site 320373004554 putative PBP binding loops; other site 320373004555 ABC-ATPase subunit interface; other site 320373004556 cystine transporter subunit; Provisional; Region: PRK11260 320373004557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373004558 substrate binding pocket [chemical binding]; other site 320373004559 membrane-bound complex binding site; other site 320373004560 hinge residues; other site 320373004561 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 320373004562 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 320373004563 quinone interaction residues [chemical binding]; other site 320373004564 active site 320373004565 catalytic residues [active] 320373004566 FMN binding site [chemical binding]; other site 320373004567 substrate binding site [chemical binding]; other site 320373004568 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 320373004569 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 320373004570 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 320373004571 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 320373004572 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 320373004573 nudix motif; other site 320373004574 hypothetical protein; Provisional; Region: PRK02487 320373004575 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 320373004576 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 320373004577 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373004578 substrate binding site [chemical binding]; other site 320373004579 oxyanion hole (OAH) forming residues; other site 320373004580 trimer interface [polypeptide binding]; other site 320373004581 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 320373004582 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 320373004583 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 320373004584 active site 320373004585 dimer interface [polypeptide binding]; other site 320373004586 non-prolyl cis peptide bond; other site 320373004587 insertion regions; other site 320373004588 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 320373004589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373004590 dimer interface [polypeptide binding]; other site 320373004591 conserved gate region; other site 320373004592 putative PBP binding loops; other site 320373004593 ABC-ATPase subunit interface; other site 320373004594 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 320373004595 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320373004596 Walker A/P-loop; other site 320373004597 ATP binding site [chemical binding]; other site 320373004598 Q-loop/lid; other site 320373004599 ABC transporter signature motif; other site 320373004600 Walker B; other site 320373004601 D-loop; other site 320373004602 H-loop/switch region; other site 320373004603 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 320373004604 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 320373004605 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 320373004606 FMN binding site [chemical binding]; other site 320373004607 active site 320373004608 catalytic residues [active] 320373004609 substrate binding site [chemical binding]; other site 320373004610 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 320373004611 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 320373004612 Predicted transcriptional regulators [Transcription]; Region: COG1733 320373004613 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 320373004614 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320373004615 CoenzymeA binding site [chemical binding]; other site 320373004616 subunit interaction site [polypeptide binding]; other site 320373004617 PHB binding site; other site 320373004618 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320373004619 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 320373004620 active site 320373004621 catalytic tetrad [active] 320373004622 Predicted permease; Region: DUF318; cl17795 320373004623 ABC-2 type transporter; Region: ABC2_membrane; cl17235 320373004624 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320373004625 nodulation ABC transporter NodI; Provisional; Region: PRK13537 320373004626 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 320373004627 Walker A/P-loop; other site 320373004628 ATP binding site [chemical binding]; other site 320373004629 Q-loop/lid; other site 320373004630 ABC transporter signature motif; other site 320373004631 Walker B; other site 320373004632 D-loop; other site 320373004633 H-loop/switch region; other site 320373004634 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373004635 Ligand Binding Site [chemical binding]; other site 320373004636 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 320373004637 LexA repressor; Validated; Region: PRK00215 320373004638 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 320373004639 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 320373004640 Catalytic site [active] 320373004641 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 320373004642 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373004643 substrate binding pocket [chemical binding]; other site 320373004644 membrane-bound complex binding site; other site 320373004645 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 320373004646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373004647 dimer interface [polypeptide binding]; other site 320373004648 conserved gate region; other site 320373004649 putative PBP binding loops; other site 320373004650 ABC-ATPase subunit interface; other site 320373004651 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 320373004652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373004653 dimer interface [polypeptide binding]; other site 320373004654 conserved gate region; other site 320373004655 putative PBP binding loops; other site 320373004656 ABC-ATPase subunit interface; other site 320373004657 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 320373004658 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 320373004659 Walker A/P-loop; other site 320373004660 ATP binding site [chemical binding]; other site 320373004661 Q-loop/lid; other site 320373004662 ABC transporter signature motif; other site 320373004663 Walker B; other site 320373004664 D-loop; other site 320373004665 H-loop/switch region; other site 320373004666 TOBE-like domain; Region: TOBE_3; pfam12857 320373004667 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 320373004668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373004669 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 320373004670 substrate binding site [chemical binding]; other site 320373004671 dimerization interface [polypeptide binding]; other site 320373004672 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 320373004673 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320373004674 ligand binding site [chemical binding]; other site 320373004675 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 320373004676 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320373004677 Walker A/P-loop; other site 320373004678 ATP binding site [chemical binding]; other site 320373004679 Q-loop/lid; other site 320373004680 ABC transporter signature motif; other site 320373004681 Walker B; other site 320373004682 D-loop; other site 320373004683 H-loop/switch region; other site 320373004684 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320373004685 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373004686 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373004687 TM-ABC transporter signature motif; other site 320373004688 Transcriptional regulators [Transcription]; Region: PurR; COG1609 320373004689 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 320373004690 DNA binding site [nucleotide binding] 320373004691 domain linker motif; other site 320373004692 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 320373004693 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320373004694 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 320373004695 substrate binding site [chemical binding]; other site 320373004696 dimer interface [polypeptide binding]; other site 320373004697 ATP binding site [chemical binding]; other site 320373004698 Tar ligand binding domain homologue; Region: TarH; pfam02203 320373004699 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 320373004700 dimerization interface [polypeptide binding]; other site 320373004701 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 320373004702 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373004703 dimer interface [polypeptide binding]; other site 320373004704 putative CheW interface [polypeptide binding]; other site 320373004705 PrkA family serine protein kinase; Provisional; Region: PRK15455 320373004706 AAA ATPase domain; Region: AAA_16; pfam13191 320373004707 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 320373004708 hypothetical protein; Provisional; Region: PRK05325 320373004709 SpoVR family protein; Provisional; Region: PRK11767 320373004710 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 320373004711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373004712 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 320373004713 putative substrate translocation pore; other site 320373004714 NMT1-like family; Region: NMT1_2; pfam13379 320373004715 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 320373004716 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 320373004717 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320373004718 Walker A/P-loop; other site 320373004719 ATP binding site [chemical binding]; other site 320373004720 Q-loop/lid; other site 320373004721 ABC transporter signature motif; other site 320373004722 Walker B; other site 320373004723 D-loop; other site 320373004724 H-loop/switch region; other site 320373004725 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 320373004726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373004727 putative PBP binding loops; other site 320373004728 dimer interface [polypeptide binding]; other site 320373004729 ABC-ATPase subunit interface; other site 320373004730 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 320373004731 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 320373004732 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 320373004733 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373004734 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 320373004735 AAA domain; Region: AAA_31; pfam13614 320373004736 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 320373004737 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 320373004738 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 320373004739 ATP binding site [chemical binding]; other site 320373004740 Walker A motif; other site 320373004741 hexamer interface [polypeptide binding]; other site 320373004742 Walker B motif; other site 320373004743 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 320373004744 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373004745 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 320373004746 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373004747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 320373004748 binding surface 320373004749 TPR motif; other site 320373004750 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 320373004751 TadE-like protein; Region: TadE; pfam07811 320373004752 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320373004753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373004754 substrate binding pocket [chemical binding]; other site 320373004755 membrane-bound complex binding site; other site 320373004756 hinge residues; other site 320373004757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373004758 dimer interface [polypeptide binding]; other site 320373004759 conserved gate region; other site 320373004760 putative PBP binding loops; other site 320373004761 ABC-ATPase subunit interface; other site 320373004762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373004763 dimer interface [polypeptide binding]; other site 320373004764 conserved gate region; other site 320373004765 putative PBP binding loops; other site 320373004766 ABC-ATPase subunit interface; other site 320373004767 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 320373004768 Peptidase family M23; Region: Peptidase_M23; pfam01551 320373004769 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 320373004770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373004771 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 320373004772 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 320373004773 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373004774 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373004775 multidrug efflux protein; Reviewed; Region: PRK09577 320373004776 Protein export membrane protein; Region: SecD_SecF; cl14618 320373004777 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 320373004778 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 320373004779 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 320373004780 PapC N-terminal domain; Region: PapC_N; pfam13954 320373004781 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 320373004782 PapC C-terminal domain; Region: PapC_C; pfam13953 320373004783 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 320373004784 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 320373004785 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 320373004786 Fimbrial protein; Region: Fimbrial; pfam00419 320373004787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 320373004788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373004789 Walker A/P-loop; other site 320373004790 ATP binding site [chemical binding]; other site 320373004791 Q-loop/lid; other site 320373004792 ABC transporter signature motif; other site 320373004793 Walker B; other site 320373004794 D-loop; other site 320373004795 H-loop/switch region; other site 320373004796 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 320373004797 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 320373004798 Ligand Binding Site [chemical binding]; other site 320373004799 Molecular Tunnel; other site 320373004800 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 320373004801 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320373004802 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320373004803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373004804 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 320373004805 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320373004806 putative ligand binding site [chemical binding]; other site 320373004807 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 320373004808 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320373004809 Walker A/P-loop; other site 320373004810 ATP binding site [chemical binding]; other site 320373004811 Q-loop/lid; other site 320373004812 ABC transporter signature motif; other site 320373004813 Walker B; other site 320373004814 D-loop; other site 320373004815 H-loop/switch region; other site 320373004816 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320373004817 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 320373004818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373004819 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373004820 TM-ABC transporter signature motif; other site 320373004821 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 320373004822 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320373004823 NAD(P) binding site [chemical binding]; other site 320373004824 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 320373004825 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 320373004826 N- and C-terminal domain interface [polypeptide binding]; other site 320373004827 putative active site [active] 320373004828 MgATP binding site [chemical binding]; other site 320373004829 catalytic site [active] 320373004830 metal binding site [ion binding]; metal-binding site 320373004831 putative xylulose binding site [chemical binding]; other site 320373004832 putative homodimer interface [polypeptide binding]; other site 320373004833 short chain dehydrogenase; Provisional; Region: PRK07060 320373004834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373004835 NAD(P) binding site [chemical binding]; other site 320373004836 active site 320373004837 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 320373004838 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373004839 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 320373004840 DNA binding residues [nucleotide binding] 320373004841 MbtH-like protein; Region: MbtH; cl01279 320373004842 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 320373004843 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 320373004844 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 320373004845 Walker A/P-loop; other site 320373004846 ATP binding site [chemical binding]; other site 320373004847 Q-loop/lid; other site 320373004848 ABC transporter signature motif; other site 320373004849 Walker B; other site 320373004850 D-loop; other site 320373004851 H-loop/switch region; other site 320373004852 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 320373004853 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 320373004854 dimer interface [polypeptide binding]; other site 320373004855 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 320373004856 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 320373004857 ABC-ATPase subunit interface; other site 320373004858 dimer interface [polypeptide binding]; other site 320373004859 putative PBP binding regions; other site 320373004860 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 320373004861 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 320373004862 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 320373004863 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 320373004864 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 320373004865 siderophore binding site; other site 320373004866 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 320373004867 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 320373004868 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 320373004869 Walker A/P-loop; other site 320373004870 ATP binding site [chemical binding]; other site 320373004871 Q-loop/lid; other site 320373004872 ABC transporter signature motif; other site 320373004873 Walker B; other site 320373004874 D-loop; other site 320373004875 H-loop/switch region; other site 320373004876 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373004877 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373004878 acyl-activating enzyme (AAE) consensus motif; other site 320373004879 AMP binding site [chemical binding]; other site 320373004880 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373004881 Condensation domain; Region: Condensation; pfam00668 320373004882 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373004883 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373004884 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373004885 acyl-activating enzyme (AAE) consensus motif; other site 320373004886 AMP binding site [chemical binding]; other site 320373004887 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373004888 Condensation domain; Region: Condensation; pfam00668 320373004889 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 320373004890 Condensation domain; Region: Condensation; pfam00668 320373004891 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373004892 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373004893 acyl-activating enzyme (AAE) consensus motif; other site 320373004894 AMP binding site [chemical binding]; other site 320373004895 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373004896 Condensation domain; Region: Condensation; pfam00668 320373004897 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373004898 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373004899 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373004900 acyl-activating enzyme (AAE) consensus motif; other site 320373004901 AMP binding site [chemical binding]; other site 320373004902 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373004903 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373004904 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 320373004905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373004906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373004907 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 320373004908 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373004909 N-terminal plug; other site 320373004910 ligand-binding site [chemical binding]; other site 320373004911 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 320373004912 catalytic site [active] 320373004913 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 320373004914 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 320373004915 catalytic triad [active] 320373004916 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 320373004917 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 320373004918 homodimer interface [polypeptide binding]; other site 320373004919 Walker A motif; other site 320373004920 ATP binding site [chemical binding]; other site 320373004921 hydroxycobalamin binding site [chemical binding]; other site 320373004922 Walker B motif; other site 320373004923 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 320373004924 High-affinity nickel-transport protein; Region: NicO; cl00964 320373004925 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 320373004926 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 320373004927 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 320373004928 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 320373004929 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 320373004930 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 320373004931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373004932 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320373004933 Walker A motif; other site 320373004934 ATP binding site [chemical binding]; other site 320373004935 Walker B motif; other site 320373004936 arginine finger; other site 320373004937 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 320373004938 metal ion-dependent adhesion site (MIDAS); other site 320373004939 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 320373004940 Serine hydrolase (FSH1); Region: FSH1; pfam03959 320373004941 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 320373004942 active site 320373004943 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 320373004944 aromatic chitin/cellulose binding site residues [chemical binding]; other site 320373004945 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 320373004946 aromatic chitin/cellulose binding site residues [chemical binding]; other site 320373004947 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 320373004948 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 320373004949 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 320373004950 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 320373004951 active site 320373004952 SAM binding site [chemical binding]; other site 320373004953 homodimer interface [polypeptide binding]; other site 320373004954 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 320373004955 active site 320373004956 SAM binding site [chemical binding]; other site 320373004957 homodimer interface [polypeptide binding]; other site 320373004958 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 320373004959 Precorrin-8X methylmutase; Region: CbiC; pfam02570 320373004960 precorrin-3B synthase; Region: CobG; TIGR02435 320373004961 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320373004962 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320373004963 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 320373004964 active site 320373004965 putative homodimer interface [polypeptide binding]; other site 320373004966 SAM binding site [chemical binding]; other site 320373004967 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 320373004968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373004969 S-adenosylmethionine binding site [chemical binding]; other site 320373004970 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 320373004971 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 320373004972 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 320373004973 active site 320373004974 SAM binding site [chemical binding]; other site 320373004975 homodimer interface [polypeptide binding]; other site 320373004976 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 320373004977 putative cyanate transporter; Provisional; Region: cynX; PRK09705 320373004978 MarR family; Region: MarR_2; cl17246 320373004979 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320373004980 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320373004981 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320373004982 dimerization interface [polypeptide binding]; other site 320373004983 ligand binding site [chemical binding]; other site 320373004984 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320373004985 MarR family; Region: MarR_2; pfam12802 320373004986 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 320373004987 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 320373004988 C-terminal domain interface [polypeptide binding]; other site 320373004989 GSH binding site (G-site) [chemical binding]; other site 320373004990 dimer interface [polypeptide binding]; other site 320373004991 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 320373004992 dimer interface [polypeptide binding]; other site 320373004993 N-terminal domain interface [polypeptide binding]; other site 320373004994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373004995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373004996 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 320373004997 putative effector binding pocket; other site 320373004998 putative dimerization interface [polypeptide binding]; other site 320373004999 Domain of unknown function (DUF336); Region: DUF336; pfam03928 320373005000 short chain dehydrogenase; Provisional; Region: PRK09291 320373005001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373005002 NAD(P) binding site [chemical binding]; other site 320373005003 active site 320373005004 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 320373005005 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 320373005006 putative substrate binding site [chemical binding]; other site 320373005007 nucleotide binding site [chemical binding]; other site 320373005008 nucleotide binding site [chemical binding]; other site 320373005009 homodimer interface [polypeptide binding]; other site 320373005010 ornithine carbamoyltransferase; Validated; Region: PRK02102 320373005011 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 320373005012 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 320373005013 arginine deiminase; Provisional; Region: PRK01388 320373005014 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 320373005015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373005016 ABC-ATPase subunit interface; other site 320373005017 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 320373005018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373005019 Walker A/P-loop; other site 320373005020 ATP binding site [chemical binding]; other site 320373005021 Q-loop/lid; other site 320373005022 ABC transporter signature motif; other site 320373005023 Walker B; other site 320373005024 D-loop; other site 320373005025 H-loop/switch region; other site 320373005026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373005027 dimer interface [polypeptide binding]; other site 320373005028 conserved gate region; other site 320373005029 putative PBP binding loops; other site 320373005030 ABC-ATPase subunit interface; other site 320373005031 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 320373005032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373005033 S-adenosylmethionine binding site [chemical binding]; other site 320373005034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373005035 putative substrate translocation pore; other site 320373005036 AMP-binding domain protein; Validated; Region: PRK07529 320373005037 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373005038 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 320373005039 acyl-activating enzyme (AAE) consensus motif; other site 320373005040 putative AMP binding site [chemical binding]; other site 320373005041 putative active site [active] 320373005042 putative CoA binding site [chemical binding]; other site 320373005043 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 320373005044 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373005045 dimer interface [polypeptide binding]; other site 320373005046 putative CheW interface [polypeptide binding]; other site 320373005047 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 320373005048 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320373005049 EamA-like transporter family; Region: EamA; pfam00892 320373005050 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320373005051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373005052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373005053 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373005054 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373005055 trimer interface [polypeptide binding]; other site 320373005056 eyelet of channel; other site 320373005057 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 320373005058 Cupin-like domain; Region: Cupin_8; pfam13621 320373005059 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373005060 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 320373005061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373005062 homodimer interface [polypeptide binding]; other site 320373005063 catalytic residue [active] 320373005064 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373005065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373005066 S-adenosylmethionine binding site [chemical binding]; other site 320373005067 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 320373005068 active site 320373005069 substrate binding site [chemical binding]; other site 320373005070 cosubstrate binding site; other site 320373005071 catalytic site [active] 320373005072 argininosuccinate synthase; Provisional; Region: PRK13820 320373005073 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 320373005074 ANP binding site [chemical binding]; other site 320373005075 Substrate Binding Site II [chemical binding]; other site 320373005076 Substrate Binding Site I [chemical binding]; other site 320373005077 argininosuccinate lyase; Provisional; Region: PRK00855 320373005078 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 320373005079 active sites [active] 320373005080 tetramer interface [polypeptide binding]; other site 320373005081 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 320373005082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373005083 putative substrate translocation pore; other site 320373005084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373005085 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 320373005086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373005087 catalytic residue [active] 320373005088 dimer interface [polypeptide binding]; other site 320373005089 argininosuccinate lyase; Provisional; Region: PRK02186 320373005090 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 320373005091 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 320373005092 active sites [active] 320373005093 tetramer interface [polypeptide binding]; other site 320373005094 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373005095 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 320373005096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373005097 catalytic residue [active] 320373005098 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 320373005099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373005100 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 320373005101 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 320373005102 acyl-activating enzyme (AAE) consensus motif; other site 320373005103 active site 320373005104 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373005105 Condensation domain; Region: Condensation; pfam00668 320373005106 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373005107 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373005108 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373005109 acyl-activating enzyme (AAE) consensus motif; other site 320373005110 AMP binding site [chemical binding]; other site 320373005111 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373005112 Condensation domain; Region: Condensation; pfam00668 320373005113 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373005114 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373005115 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373005116 acyl-activating enzyme (AAE) consensus motif; other site 320373005117 AMP binding site [chemical binding]; other site 320373005118 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373005119 Condensation domain; Region: Condensation; pfam00668 320373005120 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373005121 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373005122 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373005123 acyl-activating enzyme (AAE) consensus motif; other site 320373005124 AMP binding site [chemical binding]; other site 320373005125 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373005126 Condensation domain; Region: Condensation; pfam00668 320373005127 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373005128 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373005129 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373005130 acyl-activating enzyme (AAE) consensus motif; other site 320373005131 AMP binding site [chemical binding]; other site 320373005132 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373005133 Condensation domain; Region: Condensation; pfam00668 320373005134 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373005135 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373005136 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373005137 acyl-activating enzyme (AAE) consensus motif; other site 320373005138 AMP binding site [chemical binding]; other site 320373005139 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373005140 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373005141 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 320373005142 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 320373005143 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 320373005144 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 320373005145 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 320373005146 active site 320373005147 Transposase, Mutator family; Region: Transposase_mut; pfam00872 320373005148 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 320373005149 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 320373005150 nucleophilic elbow; other site 320373005151 catalytic triad; other site 320373005152 transcriptional regulator FimZ; Provisional; Region: PRK09935 320373005153 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373005154 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 320373005155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373005156 dimer interface [polypeptide binding]; other site 320373005157 phosphorylation site [posttranslational modification] 320373005158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373005159 ATP binding site [chemical binding]; other site 320373005160 Mg2+ binding site [ion binding]; other site 320373005161 G-X-G motif; other site 320373005162 Response regulator receiver domain; Region: Response_reg; pfam00072 320373005163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373005164 active site 320373005165 phosphorylation site [posttranslational modification] 320373005166 intermolecular recognition site; other site 320373005167 dimerization interface [polypeptide binding]; other site 320373005168 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373005169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373005170 active site 320373005171 phosphorylation site [posttranslational modification] 320373005172 intermolecular recognition site; other site 320373005173 dimerization interface [polypeptide binding]; other site 320373005174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373005175 DNA binding residues [nucleotide binding] 320373005176 dimerization interface [polypeptide binding]; other site 320373005177 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320373005178 Haemagglutinin; Region: HIM; pfam05662 320373005179 YadA-like C-terminal region; Region: YadA; pfam03895 320373005180 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 320373005181 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 320373005182 PapC N-terminal domain; Region: PapC_N; pfam13954 320373005183 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 320373005184 PapC C-terminal domain; Region: PapC_C; pfam13953 320373005185 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 320373005186 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 320373005187 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 320373005188 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 320373005189 MEKHLA domain; Region: MEKHLA; pfam08670 320373005190 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 320373005191 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 320373005192 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 320373005193 dimer interface [polypeptide binding]; other site 320373005194 active site 320373005195 metal binding site [ion binding]; metal-binding site 320373005196 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 320373005197 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 320373005198 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 320373005199 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 320373005200 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320373005201 iron-sulfur cluster [ion binding]; other site 320373005202 [2Fe-2S] cluster binding site [ion binding]; other site 320373005203 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 320373005204 dihydroxyacetone kinase; Provisional; Region: PRK14479 320373005205 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 320373005206 DAK2 domain; Region: Dak2; pfam02734 320373005207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373005208 dimerization interface [polypeptide binding]; other site 320373005209 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373005210 dimer interface [polypeptide binding]; other site 320373005211 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 320373005212 putative CheW interface [polypeptide binding]; other site 320373005213 ABC-2 type transporter; Region: ABC2_membrane; cl17235 320373005214 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320373005215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 320373005216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373005217 Walker A/P-loop; other site 320373005218 ATP binding site [chemical binding]; other site 320373005219 Q-loop/lid; other site 320373005220 ABC transporter signature motif; other site 320373005221 Walker B; other site 320373005222 D-loop; other site 320373005223 H-loop/switch region; other site 320373005224 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 320373005225 ApbE family; Region: ApbE; pfam02424 320373005226 nitrous-oxide reductase; Validated; Region: PRK02888 320373005227 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320373005228 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 320373005229 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 320373005230 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 320373005231 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 320373005232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373005233 Walker A/P-loop; other site 320373005234 ATP binding site [chemical binding]; other site 320373005235 Q-loop/lid; other site 320373005236 ABC transporter signature motif; other site 320373005237 Walker B; other site 320373005238 D-loop; other site 320373005239 H-loop/switch region; other site 320373005240 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 320373005241 NosL; Region: NosL; pfam05573 320373005242 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 320373005243 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 320373005244 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 320373005245 4Fe-4S binding domain; Region: Fer4_5; pfam12801 320373005246 4Fe-4S binding domain; Region: Fer4_5; pfam12801 320373005247 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 320373005248 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 320373005249 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 320373005250 Mechanosensitive ion channel; Region: MS_channel; pfam00924 320373005251 YciI-like protein; Reviewed; Region: PRK12866 320373005252 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 320373005253 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 320373005254 oligomer interface [polypeptide binding]; other site 320373005255 metal binding site [ion binding]; metal-binding site 320373005256 metal binding site [ion binding]; metal-binding site 320373005257 putative Cl binding site [ion binding]; other site 320373005258 basic sphincter; other site 320373005259 hydrophobic gate; other site 320373005260 periplasmic entrance; other site 320373005261 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 320373005262 AAA domain; Region: AAA_33; pfam13671 320373005263 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 320373005264 active site 320373005265 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 320373005266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373005267 Double zinc ribbon; Region: DZR; pfam12773 320373005268 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 320373005269 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 320373005270 AsnC family; Region: AsnC_trans_reg; pfam01037 320373005271 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373005272 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373005273 acyl-activating enzyme (AAE) consensus motif; other site 320373005274 AMP binding site [chemical binding]; other site 320373005275 thioester reductase domain; Region: Thioester-redct; TIGR01746 320373005276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373005277 NAD(P) binding site [chemical binding]; other site 320373005278 active site 320373005279 LTXXQ motif family protein; Region: LTXXQ; pfam07813 320373005280 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 320373005281 PGDYG protein; Region: PGDYG; pfam14083 320373005282 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 320373005283 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 320373005284 Transcriptional regulators [Transcription]; Region: PurR; COG1609 320373005285 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 320373005286 DNA binding site [nucleotide binding] 320373005287 domain linker motif; other site 320373005288 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 320373005289 putative ligand binding site [chemical binding]; other site 320373005290 putative dimerization interface [polypeptide binding]; other site 320373005291 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 320373005292 dimerization interface [polypeptide binding]; other site 320373005293 ligand binding site [chemical binding]; other site 320373005294 NADP binding site [chemical binding]; other site 320373005295 catalytic site [active] 320373005296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373005297 D-galactonate transporter; Region: 2A0114; TIGR00893 320373005298 putative substrate translocation pore; other site 320373005299 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320373005300 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 320373005301 substrate binding site [chemical binding]; other site 320373005302 ATP binding site [chemical binding]; other site 320373005303 SdpI/YhfL protein family; Region: SdpI; pfam13630 320373005304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373005305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373005306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373005307 dimerization interface [polypeptide binding]; other site 320373005308 Predicted membrane protein [Function unknown]; Region: COG2855 320373005309 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 320373005310 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 320373005311 Cl- selectivity filter; other site 320373005312 Cl- binding residues [ion binding]; other site 320373005313 pore gating glutamate residue; other site 320373005314 dimer interface [polypeptide binding]; other site 320373005315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 320373005316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373005317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373005318 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 320373005319 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373005320 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373005321 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 320373005322 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373005323 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 320373005324 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 320373005325 DNA binding residues [nucleotide binding] 320373005326 putative dimer interface [polypeptide binding]; other site 320373005327 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 320373005328 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 320373005329 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373005330 active site 320373005331 CoA binding site [chemical binding]; other site 320373005332 AMP binding site [chemical binding]; other site 320373005333 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373005334 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 320373005335 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373005336 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 320373005337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373005338 catalytic residue [active] 320373005339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373005340 putative substrate translocation pore; other site 320373005341 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 320373005342 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 320373005343 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 320373005344 active site 320373005345 PAS fold; Region: PAS_4; pfam08448 320373005346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373005347 putative active site [active] 320373005348 heme pocket [chemical binding]; other site 320373005349 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320373005350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373005351 Walker A motif; other site 320373005352 ATP binding site [chemical binding]; other site 320373005353 Walker B motif; other site 320373005354 arginine finger; other site 320373005355 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 320373005356 DNA-binding interface [nucleotide binding]; DNA binding site 320373005357 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 320373005358 Putative phosphatase (DUF442); Region: DUF442; cl17385 320373005359 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 320373005360 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 320373005361 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 320373005362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373005363 dimer interface [polypeptide binding]; other site 320373005364 conserved gate region; other site 320373005365 putative PBP binding loops; other site 320373005366 ABC-ATPase subunit interface; other site 320373005367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373005368 dimer interface [polypeptide binding]; other site 320373005369 conserved gate region; other site 320373005370 putative PBP binding loops; other site 320373005371 ABC-ATPase subunit interface; other site 320373005372 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 320373005373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373005374 Walker A/P-loop; other site 320373005375 ATP binding site [chemical binding]; other site 320373005376 Q-loop/lid; other site 320373005377 ABC transporter signature motif; other site 320373005378 Walker B; other site 320373005379 D-loop; other site 320373005380 H-loop/switch region; other site 320373005381 TOBE domain; Region: TOBE_2; pfam08402 320373005382 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 320373005383 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320373005384 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 320373005385 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 320373005386 Predicted Fe-S protein [General function prediction only]; Region: COG3313 320373005387 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320373005388 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 320373005389 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 320373005390 FMN binding site [chemical binding]; other site 320373005391 substrate binding site [chemical binding]; other site 320373005392 putative catalytic residue [active] 320373005393 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 320373005394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320373005395 NAD binding site [chemical binding]; other site 320373005396 catalytic residues [active] 320373005397 Burkholderia Lethal Factor 1; Region: BPSL1549; cd12812 320373005398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373005399 H-loop/switch region; other site 320373005400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320373005401 HTH-like domain; Region: HTH_21; pfam13276 320373005402 Integrase core domain; Region: rve; pfam00665 320373005403 Integrase core domain; Region: rve_3; pfam13683 320373005404 Transposase; Region: HTH_Tnp_1; pfam01527 320373005405 H-NS histone family; Region: Histone_HNS; pfam00816 320373005406 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373005407 FRG domain; Region: FRG; cl07460 320373005408 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320373005409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373005410 non-specific DNA binding site [nucleotide binding]; other site 320373005411 salt bridge; other site 320373005412 sequence-specific DNA binding site [nucleotide binding]; other site 320373005413 Competence protein CoiA-like family; Region: CoiA; cl11541 320373005414 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 320373005415 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 320373005416 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 320373005417 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373005418 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373005419 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 320373005420 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 320373005421 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 320373005422 Transposase; Region: HTH_Tnp_1; pfam01527 320373005423 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 320373005424 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320373005425 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320373005426 ABC transporter; Region: ABC_tran_2; pfam12848 320373005427 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320373005428 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 320373005429 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 320373005430 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 320373005431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373005432 Walker A/P-loop; other site 320373005433 ATP binding site [chemical binding]; other site 320373005434 Q-loop/lid; other site 320373005435 ABC transporter signature motif; other site 320373005436 Walker B; other site 320373005437 D-loop; other site 320373005438 H-loop/switch region; other site 320373005439 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 320373005440 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 320373005441 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 320373005442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373005443 motif II; other site 320373005444 cystathionine beta-lyase; Provisional; Region: PRK07050 320373005445 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373005446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373005447 catalytic residue [active] 320373005448 beta-ketothiolase; Provisional; Region: PRK09051 320373005449 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320373005450 dimer interface [polypeptide binding]; other site 320373005451 active site 320373005452 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320373005453 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 320373005454 substrate binding site [chemical binding]; other site 320373005455 ATP binding site [chemical binding]; other site 320373005456 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 320373005457 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 320373005458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373005459 FeS/SAM binding site; other site 320373005460 TRAM domain; Region: TRAM; cl01282 320373005461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 320373005462 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 320373005463 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 320373005464 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 320373005465 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 320373005466 NAD(P) binding site [chemical binding]; other site 320373005467 homotetramer interface [polypeptide binding]; other site 320373005468 homodimer interface [polypeptide binding]; other site 320373005469 active site 320373005470 putative acyltransferase; Provisional; Region: PRK05790 320373005471 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320373005472 dimer interface [polypeptide binding]; other site 320373005473 active site 320373005474 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 320373005475 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 320373005476 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 320373005477 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 320373005478 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 320373005479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320373005480 RNA binding surface [nucleotide binding]; other site 320373005481 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 320373005482 active site 320373005483 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 320373005484 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 320373005485 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 320373005486 DEAD_2; Region: DEAD_2; pfam06733 320373005487 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 320373005488 Protein of unknown function (DUF465); Region: DUF465; pfam04325 320373005489 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 320373005490 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 320373005491 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 320373005492 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 320373005493 RNA binding site [nucleotide binding]; other site 320373005494 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 320373005495 potassium uptake protein; Region: kup; TIGR00794 320373005496 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 320373005497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373005498 active site 320373005499 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 320373005500 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 320373005501 GDP-binding site [chemical binding]; other site 320373005502 ACT binding site; other site 320373005503 IMP binding site; other site 320373005504 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 320373005505 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 320373005506 dimer interface [polypeptide binding]; other site 320373005507 motif 1; other site 320373005508 active site 320373005509 motif 2; other site 320373005510 motif 3; other site 320373005511 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 320373005512 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 320373005513 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 320373005514 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 320373005515 HflK protein; Region: hflK; TIGR01933 320373005516 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 320373005517 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 320373005518 HflX GTPase family; Region: HflX; cd01878 320373005519 G1 box; other site 320373005520 GTP/Mg2+ binding site [chemical binding]; other site 320373005521 Switch I region; other site 320373005522 G2 box; other site 320373005523 G3 box; other site 320373005524 Switch II region; other site 320373005525 G4 box; other site 320373005526 G5 box; other site 320373005527 bacterial Hfq-like; Region: Hfq; cd01716 320373005528 hexamer interface [polypeptide binding]; other site 320373005529 Sm1 motif; other site 320373005530 RNA binding site [nucleotide binding]; other site 320373005531 Sm2 motif; other site 320373005532 GTP-binding protein Der; Reviewed; Region: PRK00093 320373005533 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 320373005534 G1 box; other site 320373005535 GTP/Mg2+ binding site [chemical binding]; other site 320373005536 Switch I region; other site 320373005537 G2 box; other site 320373005538 Switch II region; other site 320373005539 G3 box; other site 320373005540 G4 box; other site 320373005541 G5 box; other site 320373005542 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 320373005543 G1 box; other site 320373005544 GTP/Mg2+ binding site [chemical binding]; other site 320373005545 Switch I region; other site 320373005546 G2 box; other site 320373005547 G3 box; other site 320373005548 Switch II region; other site 320373005549 G4 box; other site 320373005550 G5 box; other site 320373005551 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 320373005552 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 320373005553 Trp docking motif [polypeptide binding]; other site 320373005554 active site 320373005555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 320373005556 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 320373005557 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 320373005558 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 320373005559 dimer interface [polypeptide binding]; other site 320373005560 motif 1; other site 320373005561 active site 320373005562 motif 2; other site 320373005563 motif 3; other site 320373005564 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 320373005565 anticodon binding site; other site 320373005566 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 320373005567 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 320373005568 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 320373005569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373005570 non-specific DNA binding site [nucleotide binding]; other site 320373005571 salt bridge; other site 320373005572 sequence-specific DNA binding site [nucleotide binding]; other site 320373005573 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 320373005574 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 320373005575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373005576 FeS/SAM binding site; other site 320373005577 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 320373005578 active site 320373005579 multimer interface [polypeptide binding]; other site 320373005580 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 320373005581 YccA-like proteins; Region: YccA_like; cd10433 320373005582 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 320373005583 TRAM domain; Region: TRAM; cl01282 320373005584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373005585 S-adenosylmethionine binding site [chemical binding]; other site 320373005586 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 320373005587 putative catalytic site [active] 320373005588 putative metal binding site [ion binding]; other site 320373005589 putative phosphate binding site [ion binding]; other site 320373005590 putative catalytic site [active] 320373005591 putative phosphate binding site [ion binding]; other site 320373005592 putative metal binding site [ion binding]; other site 320373005593 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 320373005594 active site 320373005595 catalytic site [active] 320373005596 substrate binding site [chemical binding]; other site 320373005597 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 320373005598 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 320373005599 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 320373005600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373005601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373005602 DNA binding residues [nucleotide binding] 320373005603 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320373005604 Peptidase family M23; Region: Peptidase_M23; pfam01551 320373005605 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 320373005606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373005607 S-adenosylmethionine binding site [chemical binding]; other site 320373005608 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 320373005609 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320373005610 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320373005611 recombination protein RecR; Reviewed; Region: recR; PRK00076 320373005612 RecR protein; Region: RecR; pfam02132 320373005613 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 320373005614 putative active site [active] 320373005615 putative metal-binding site [ion binding]; other site 320373005616 tetramer interface [polypeptide binding]; other site 320373005617 hypothetical protein; Validated; Region: PRK00153 320373005618 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 320373005619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373005620 Walker A motif; other site 320373005621 ATP binding site [chemical binding]; other site 320373005622 Walker B motif; other site 320373005623 arginine finger; other site 320373005624 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 320373005625 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320373005626 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320373005627 catalytic residues [active] 320373005628 transcription termination factor Rho; Provisional; Region: rho; PRK09376 320373005629 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 320373005630 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 320373005631 RNA binding site [nucleotide binding]; other site 320373005632 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 320373005633 multimer interface [polypeptide binding]; other site 320373005634 Walker A motif; other site 320373005635 ATP binding site [chemical binding]; other site 320373005636 Walker B motif; other site 320373005637 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 320373005638 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 320373005639 DNA binding residues [nucleotide binding] 320373005640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373005641 putative substrate translocation pore; other site 320373005642 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320373005643 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 320373005644 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 320373005645 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 320373005646 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 320373005647 putative efflux protein, MATE family; Region: matE; TIGR00797 320373005648 cation binding site [ion binding]; other site 320373005649 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 320373005650 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 320373005651 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 320373005652 DNA binding residues [nucleotide binding] 320373005653 putative dimer interface [polypeptide binding]; other site 320373005654 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 320373005655 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 320373005656 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 320373005657 Clp amino terminal domain; Region: Clp_N; pfam02861 320373005658 Clp amino terminal domain; Region: Clp_N; pfam02861 320373005659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373005660 Walker A motif; other site 320373005661 ATP binding site [chemical binding]; other site 320373005662 Walker B motif; other site 320373005663 arginine finger; other site 320373005664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373005665 Walker A motif; other site 320373005666 ATP binding site [chemical binding]; other site 320373005667 Walker B motif; other site 320373005668 arginine finger; other site 320373005669 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320373005670 Transcriptional regulator; Region: Rrf2; cl17282 320373005671 Rrf2 family protein; Region: rrf2_super; TIGR00738 320373005672 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 320373005673 apolar tunnel; other site 320373005674 heme binding site [chemical binding]; other site 320373005675 dimerization interface [polypeptide binding]; other site 320373005676 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 320373005677 MoaE homodimer interface [polypeptide binding]; other site 320373005678 MoaD interaction [polypeptide binding]; other site 320373005679 active site residues [active] 320373005680 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 320373005681 MoaE interaction surface [polypeptide binding]; other site 320373005682 MoeB interaction surface [polypeptide binding]; other site 320373005683 thiocarboxylated glycine; other site 320373005684 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 320373005685 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 320373005686 dimer interface [polypeptide binding]; other site 320373005687 putative functional site; other site 320373005688 putative MPT binding site; other site 320373005689 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 320373005690 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 320373005691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373005692 catalytic residue [active] 320373005693 homoserine dehydrogenase; Provisional; Region: PRK06349 320373005694 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 320373005695 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 320373005696 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 320373005697 aminotransferase AlaT; Validated; Region: PRK09265 320373005698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373005699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373005700 homodimer interface [polypeptide binding]; other site 320373005701 catalytic residue [active] 320373005702 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 320373005703 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 320373005704 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 320373005705 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 320373005706 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 320373005707 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 320373005708 inhibitor-cofactor binding pocket; inhibition site 320373005709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373005710 catalytic residue [active] 320373005711 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 320373005712 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 320373005713 Ligand binding site; other site 320373005714 Putative Catalytic site; other site 320373005715 DXD motif; other site 320373005716 putative formyltransferase; Provisional; Region: PRK06988 320373005717 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 320373005718 active site 320373005719 substrate binding site [chemical binding]; other site 320373005720 cosubstrate binding site; other site 320373005721 catalytic site [active] 320373005722 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 320373005723 active site 320373005724 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 320373005725 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 320373005726 NAD binding site [chemical binding]; other site 320373005727 substrate binding site [chemical binding]; other site 320373005728 active site 320373005729 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 320373005730 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 320373005731 putative active site [active] 320373005732 putative catalytic site [active] 320373005733 putative Zn binding site [ion binding]; other site 320373005734 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 320373005735 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320373005736 catalytic triad [active] 320373005737 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 320373005738 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 320373005739 putative active site [active] 320373005740 PhoH-like protein; Region: PhoH; pfam02562 320373005741 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 320373005742 NlpC/P60 family; Region: NLPC_P60; pfam00877 320373005743 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 320373005744 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 320373005745 replicative DNA helicase; Provisional; Region: PRK07004 320373005746 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 320373005747 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 320373005748 Walker A motif; other site 320373005749 ATP binding site [chemical binding]; other site 320373005750 Walker B motif; other site 320373005751 DNA binding loops [nucleotide binding] 320373005752 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 320373005753 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 320373005754 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 320373005755 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 320373005756 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 320373005757 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 320373005758 Putative zinc-finger; Region: zf-HC2; pfam13490 320373005759 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 320373005760 RNA polymerase sigma factor; Provisional; Region: PRK12533 320373005761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373005762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373005763 DNA binding residues [nucleotide binding] 320373005764 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320373005765 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320373005766 active site 320373005767 metal binding site [ion binding]; metal-binding site 320373005768 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320373005769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373005770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373005771 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373005772 putative effector binding pocket; other site 320373005773 dimerization interface [polypeptide binding]; other site 320373005774 glyoxylate carboligase; Provisional; Region: PRK11269 320373005775 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373005776 PYR/PP interface [polypeptide binding]; other site 320373005777 dimer interface [polypeptide binding]; other site 320373005778 TPP binding site [chemical binding]; other site 320373005779 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373005780 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 320373005781 TPP-binding site [chemical binding]; other site 320373005782 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 320373005783 tartronate semialdehyde reductase; Provisional; Region: PRK15059 320373005784 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 320373005785 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 320373005786 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320373005787 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 320373005788 active site 320373005789 homodimer interface [polypeptide binding]; other site 320373005790 homotetramer interface [polypeptide binding]; other site 320373005791 psiF repeat; Region: PsiF_repeat; pfam07769 320373005792 psiF repeat; Region: PsiF_repeat; pfam07769 320373005793 Domain of unknown function DUF221; Region: DUF221; pfam02714 320373005794 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 320373005795 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 320373005796 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373005797 putative ADP-binding pocket [chemical binding]; other site 320373005798 Predicted ATPase [General function prediction only]; Region: COG4637 320373005799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373005800 Walker A/P-loop; other site 320373005801 ATP binding site [chemical binding]; other site 320373005802 Q-loop/lid; other site 320373005803 ABC transporter signature motif; other site 320373005804 Walker B; other site 320373005805 D-loop; other site 320373005806 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 320373005807 Mechanosensitive ion channel; Region: MS_channel; pfam00924 320373005808 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 320373005809 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 320373005810 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 320373005811 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 320373005812 active site 320373005813 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 320373005814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373005815 Coenzyme A binding pocket [chemical binding]; other site 320373005816 DNA polymerase III subunit delta'; Validated; Region: PRK06964 320373005817 DNA polymerase III subunit delta'; Validated; Region: PRK08485 320373005818 thymidylate kinase; Validated; Region: tmk; PRK00698 320373005819 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 320373005820 TMP-binding site; other site 320373005821 ATP-binding site [chemical binding]; other site 320373005822 YceG-like family; Region: YceG; pfam02618 320373005823 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 320373005824 dimerization interface [polypeptide binding]; other site 320373005825 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 320373005826 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 320373005827 NRDE protein; Region: NRDE; cl01315 320373005828 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 320373005829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373005830 Coenzyme A binding pocket [chemical binding]; other site 320373005831 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 320373005832 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 320373005833 substrate binding pocket [chemical binding]; other site 320373005834 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 320373005835 Prostaglandin dehydrogenases; Region: PGDH; cd05288 320373005836 NAD(P) binding site [chemical binding]; other site 320373005837 substrate binding site [chemical binding]; other site 320373005838 dimer interface [polypeptide binding]; other site 320373005839 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320373005840 CoenzymeA binding site [chemical binding]; other site 320373005841 subunit interaction site [polypeptide binding]; other site 320373005842 PHB binding site; other site 320373005843 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 320373005844 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 320373005845 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320373005846 dimer interface [polypeptide binding]; other site 320373005847 active site 320373005848 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 320373005849 catalytic triad [active] 320373005850 metal binding site [ion binding]; metal-binding site 320373005851 conserved cis-peptide bond; other site 320373005852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373005853 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 320373005854 substrate binding site [chemical binding]; other site 320373005855 oxyanion hole (OAH) forming residues; other site 320373005856 trimer interface [polypeptide binding]; other site 320373005857 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320373005858 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320373005859 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320373005860 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 320373005861 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 320373005862 dimer interface [polypeptide binding]; other site 320373005863 acyl-activating enzyme (AAE) consensus motif; other site 320373005864 putative active site [active] 320373005865 AMP binding site [chemical binding]; other site 320373005866 putative CoA binding site [chemical binding]; other site 320373005867 Uncharacterized conserved protein [Function unknown]; Region: COG0397 320373005868 hypothetical protein; Validated; Region: PRK00029 320373005869 SelR domain; Region: SelR; pfam01641 320373005870 methionine sulfoxide reductase B; Provisional; Region: PRK00222 320373005871 intracellular septation protein A; Reviewed; Region: PRK00259 320373005872 BolA-like protein; Region: BolA; pfam01722 320373005873 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 320373005874 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320373005875 Predicted acetyltransferase [General function prediction only]; Region: COG3153 320373005876 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 320373005877 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 320373005878 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 320373005879 dimerization interface [polypeptide binding]; other site 320373005880 ATP binding site [chemical binding]; other site 320373005881 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 320373005882 dimerization interface [polypeptide binding]; other site 320373005883 ATP binding site [chemical binding]; other site 320373005884 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 320373005885 putative active site [active] 320373005886 catalytic triad [active] 320373005887 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 320373005888 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 320373005889 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 320373005890 putative substrate binding site [chemical binding]; other site 320373005891 putative ATP binding site [chemical binding]; other site 320373005892 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 320373005893 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 320373005894 active site 320373005895 dimer interface [polypeptide binding]; other site 320373005896 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 320373005897 dimer interface [polypeptide binding]; other site 320373005898 active site 320373005899 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 320373005900 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320373005901 Walker A/P-loop; other site 320373005902 ATP binding site [chemical binding]; other site 320373005903 Q-loop/lid; other site 320373005904 ABC transporter signature motif; other site 320373005905 Walker B; other site 320373005906 D-loop; other site 320373005907 H-loop/switch region; other site 320373005908 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 320373005909 active site 320373005910 catalytic triad [active] 320373005911 oxyanion hole [active] 320373005912 switch loop; other site 320373005913 SurA N-terminal domain; Region: SurA_N_3; cl07813 320373005914 periplasmic folding chaperone; Provisional; Region: PRK10788 320373005915 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320373005916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 320373005917 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 320373005918 30S subunit binding site; other site 320373005919 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 320373005920 Found in ATP-dependent protease La (LON); Region: LON; smart00464 320373005921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373005922 Walker A motif; other site 320373005923 ATP binding site [chemical binding]; other site 320373005924 Walker B motif; other site 320373005925 arginine finger; other site 320373005926 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 320373005927 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 320373005928 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 320373005929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373005930 Walker A motif; other site 320373005931 ATP binding site [chemical binding]; other site 320373005932 Walker B motif; other site 320373005933 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320373005934 Clp protease; Region: CLP_protease; pfam00574 320373005935 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 320373005936 oligomer interface [polypeptide binding]; other site 320373005937 active site residues [active] 320373005938 trigger factor; Provisional; Region: tig; PRK01490 320373005939 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 320373005940 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 320373005941 Glycerate kinase family; Region: Gly_kinase; cl00841 320373005942 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320373005943 MarR family; Region: MarR_2; pfam12802 320373005944 MarR family; Region: MarR_2; cl17246 320373005945 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 320373005946 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 320373005947 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 320373005948 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373005949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373005950 dimerization interface [polypeptide binding]; other site 320373005951 DNA binding residues [nucleotide binding] 320373005952 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373005953 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373005954 trimer interface [polypeptide binding]; other site 320373005955 eyelet of channel; other site 320373005956 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 320373005957 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320373005958 active site 320373005959 Zn binding site [ion binding]; other site 320373005960 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 320373005961 PLD-like domain; Region: PLDc_2; pfam13091 320373005962 putative active site [active] 320373005963 catalytic site [active] 320373005964 Avidin family; Region: Avidin; pfam01382 320373005965 PAAR motif; Region: PAAR_motif; pfam05488 320373005966 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 320373005967 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 320373005968 active site lid residues [active] 320373005969 substrate binding pocket [chemical binding]; other site 320373005970 catalytic residues [active] 320373005971 substrate-Mg2+ binding site; other site 320373005972 aspartate-rich region 1; other site 320373005973 aspartate-rich region 2; other site 320373005974 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 320373005975 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 320373005976 osmolarity response regulator; Provisional; Region: ompR; PRK09468 320373005977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373005978 active site 320373005979 phosphorylation site [posttranslational modification] 320373005980 intermolecular recognition site; other site 320373005981 dimerization interface [polypeptide binding]; other site 320373005982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373005983 DNA binding site [nucleotide binding] 320373005984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373005985 HAMP domain; Region: HAMP; pfam00672 320373005986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373005987 dimer interface [polypeptide binding]; other site 320373005988 phosphorylation site [posttranslational modification] 320373005989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373005990 ATP binding site [chemical binding]; other site 320373005991 Mg2+ binding site [ion binding]; other site 320373005992 G-X-G motif; other site 320373005993 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 320373005994 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 320373005995 dimer interface [polypeptide binding]; other site 320373005996 decamer (pentamer of dimers) interface [polypeptide binding]; other site 320373005997 catalytic triad [active] 320373005998 peroxidatic and resolving cysteines [active] 320373005999 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 320373006000 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 320373006001 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 320373006002 homotrimer interaction site [polypeptide binding]; other site 320373006003 zinc binding site [ion binding]; other site 320373006004 CDP-binding sites; other site 320373006005 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 320373006006 substrate binding site; other site 320373006007 dimer interface; other site 320373006008 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 320373006009 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 320373006010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320373006011 ATP binding site [chemical binding]; other site 320373006012 putative Mg++ binding site [ion binding]; other site 320373006013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373006014 nucleotide binding region [chemical binding]; other site 320373006015 ATP-binding site [chemical binding]; other site 320373006016 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 320373006017 acetylornithine deacetylase; Provisional; Region: PRK07522 320373006018 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 320373006019 metal binding site [ion binding]; metal-binding site 320373006020 putative dimer interface [polypeptide binding]; other site 320373006021 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 320373006022 tetramer interface [polypeptide binding]; other site 320373006023 hypothetical protein; Provisional; Region: PRK06815 320373006024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373006025 catalytic residue [active] 320373006026 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 320373006027 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 320373006028 Transglycosylase; Region: Transgly; pfam00912 320373006029 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320373006030 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 320373006031 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 320373006032 Tetratricopeptide repeat; Region: TPR_16; pfam13432 320373006033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373006034 TPR motif; other site 320373006035 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 320373006036 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 320373006037 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 320373006038 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 320373006039 Dodecin; Region: Dodecin; pfam07311 320373006040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373006041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373006042 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 320373006043 putative substrate binding pocket [chemical binding]; other site 320373006044 putative dimerization interface [polypeptide binding]; other site 320373006045 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 320373006046 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 320373006047 active site 320373006048 putative substrate binding pocket [chemical binding]; other site 320373006049 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 320373006050 active site 320373006051 homotetramer interface [polypeptide binding]; other site 320373006052 Predicted membrane protein [Function unknown]; Region: COG3748 320373006053 Protein of unknown function (DUF989); Region: DUF989; pfam06181 320373006054 Cytochrome c; Region: Cytochrom_C; pfam00034 320373006055 ureidoglycolate hydrolase; Provisional; Region: PRK03606 320373006056 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 320373006057 allantoicase; Provisional; Region: PRK13257 320373006058 Allantoicase repeat; Region: Allantoicase; pfam03561 320373006059 Allantoicase repeat; Region: Allantoicase; pfam03561 320373006060 OHCU decarboxylase; Region: UHCUDC; TIGR03164 320373006061 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 320373006062 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 320373006063 active site 320373006064 catalytic site [active] 320373006065 tetramer interface [polypeptide binding]; other site 320373006066 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 320373006067 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 320373006068 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 320373006069 Na binding site [ion binding]; other site 320373006070 putative substrate binding site [chemical binding]; other site 320373006071 Transcriptional regulators [Transcription]; Region: GntR; COG1802 320373006072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373006073 DNA-binding site [nucleotide binding]; DNA binding site 320373006074 FCD domain; Region: FCD; pfam07729 320373006075 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 320373006076 dimer interface [polypeptide binding]; other site 320373006077 catalytic triad [active] 320373006078 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 320373006079 nucleoside/Zn binding site; other site 320373006080 dimer interface [polypeptide binding]; other site 320373006081 catalytic motif [active] 320373006082 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 320373006083 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 320373006084 GMP synthase; Reviewed; Region: guaA; PRK00074 320373006085 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 320373006086 AMP/PPi binding site [chemical binding]; other site 320373006087 candidate oxyanion hole; other site 320373006088 catalytic triad [active] 320373006089 potential glutamine specificity residues [chemical binding]; other site 320373006090 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 320373006091 ATP Binding subdomain [chemical binding]; other site 320373006092 Ligand Binding sites [chemical binding]; other site 320373006093 Dimerization subdomain; other site 320373006094 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 320373006095 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 320373006096 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 320373006097 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 320373006098 active site 320373006099 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 320373006100 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 320373006101 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320373006102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 320373006103 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 320373006104 putative coenzyme Q binding site [chemical binding]; other site 320373006105 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 320373006106 SmpB-tmRNA interface; other site 320373006107 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 320373006108 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 320373006109 phosphoenolpyruvate synthase; Validated; Region: PRK06464 320373006110 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 320373006111 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 320373006112 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 320373006113 Phytochelatin synthase; Region: Phytochelatin; pfam05023 320373006114 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 320373006115 peptidase domain interface [polypeptide binding]; other site 320373006116 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 320373006117 active site 320373006118 catalytic triad [active] 320373006119 calcium binding site [ion binding]; other site 320373006120 PEP synthetase regulatory protein; Provisional; Region: PRK05339 320373006121 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 320373006122 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 320373006123 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 320373006124 RNA/DNA hybrid binding site [nucleotide binding]; other site 320373006125 active site 320373006126 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 320373006127 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 320373006128 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 320373006129 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 320373006130 active site 320373006131 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 320373006132 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 320373006133 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 320373006134 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 320373006135 trimer interface [polypeptide binding]; other site 320373006136 active site 320373006137 UDP-GlcNAc binding site [chemical binding]; other site 320373006138 lipid binding site [chemical binding]; lipid-binding site 320373006139 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 320373006140 periplasmic chaperone; Provisional; Region: PRK10780 320373006141 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 320373006142 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320373006143 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320373006144 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320373006145 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320373006146 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320373006147 Surface antigen; Region: Bac_surface_Ag; pfam01103 320373006148 zinc metallopeptidase RseP; Provisional; Region: PRK10779 320373006149 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 320373006150 active site 320373006151 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 320373006152 protein binding site [polypeptide binding]; other site 320373006153 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 320373006154 putative substrate binding region [chemical binding]; other site 320373006155 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 320373006156 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 320373006157 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 320373006158 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 320373006159 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 320373006160 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 320373006161 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 320373006162 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 320373006163 catalytic residue [active] 320373006164 putative FPP diphosphate binding site; other site 320373006165 putative FPP binding hydrophobic cleft; other site 320373006166 dimer interface [polypeptide binding]; other site 320373006167 putative IPP diphosphate binding site; other site 320373006168 ribosome recycling factor; Reviewed; Region: frr; PRK00083 320373006169 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 320373006170 hinge region; other site 320373006171 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 320373006172 putative nucleotide binding site [chemical binding]; other site 320373006173 uridine monophosphate binding site [chemical binding]; other site 320373006174 homohexameric interface [polypeptide binding]; other site 320373006175 elongation factor Ts; Provisional; Region: tsf; PRK09377 320373006176 UBA/TS-N domain; Region: UBA; pfam00627 320373006177 Elongation factor TS; Region: EF_TS; pfam00889 320373006178 Elongation factor TS; Region: EF_TS; pfam00889 320373006179 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 320373006180 rRNA interaction site [nucleotide binding]; other site 320373006181 S8 interaction site; other site 320373006182 putative laminin-1 binding site; other site 320373006183 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 320373006184 active site 320373006185 PII uridylyl-transferase; Provisional; Region: PRK03059 320373006186 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 320373006187 metal binding triad; other site 320373006188 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 320373006189 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320373006190 Zn2+ binding site [ion binding]; other site 320373006191 Mg2+ binding site [ion binding]; other site 320373006192 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 320373006193 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 320373006194 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 320373006195 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320373006196 RNA binding surface [nucleotide binding]; other site 320373006197 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 320373006198 active site 320373006199 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 320373006200 active site 320373006201 catalytic residues [active] 320373006202 metal binding site [ion binding]; metal-binding site 320373006203 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 320373006204 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 320373006205 nucleotide binding pocket [chemical binding]; other site 320373006206 K-X-D-G motif; other site 320373006207 catalytic site [active] 320373006208 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 320373006209 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 320373006210 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 320373006211 Dimer interface [polypeptide binding]; other site 320373006212 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 320373006213 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 320373006214 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 320373006215 Walker A/P-loop; other site 320373006216 ATP binding site [chemical binding]; other site 320373006217 Q-loop/lid; other site 320373006218 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 320373006219 Q-loop/lid; other site 320373006220 ABC transporter signature motif; other site 320373006221 Walker B; other site 320373006222 D-loop; other site 320373006223 H-loop/switch region; other site 320373006224 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320373006225 EamA-like transporter family; Region: EamA; pfam00892 320373006226 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 320373006227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373006228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373006229 homodimer interface [polypeptide binding]; other site 320373006230 catalytic residue [active] 320373006231 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 320373006232 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 320373006233 trimer interface [polypeptide binding]; other site 320373006234 active site 320373006235 substrate binding site [chemical binding]; other site 320373006236 CoA binding site [chemical binding]; other site 320373006237 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 320373006238 ArsC family; Region: ArsC; pfam03960 320373006239 putative catalytic residues [active] 320373006240 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 320373006241 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 320373006242 metal binding site [ion binding]; metal-binding site 320373006243 dimer interface [polypeptide binding]; other site 320373006244 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 320373006245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373006246 S-adenosylmethionine binding site [chemical binding]; other site 320373006247 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 320373006248 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 320373006249 putative active site [active] 320373006250 catalytic site [active] 320373006251 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 320373006252 putative active site [active] 320373006253 catalytic site [active] 320373006254 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 320373006255 catalytic residues [active] 320373006256 dimer interface [polypeptide binding]; other site 320373006257 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 320373006258 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320373006259 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320373006260 ABC transporter; Region: ABC_tran_2; pfam12848 320373006261 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320373006262 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 320373006263 DNA repair protein RadA; Provisional; Region: PRK11823 320373006264 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 320373006265 Walker A motif/ATP binding site; other site 320373006266 ATP binding site [chemical binding]; other site 320373006267 Walker B motif; other site 320373006268 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 320373006269 alanine racemase; Reviewed; Region: dadX; PRK03646 320373006270 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 320373006271 active site 320373006272 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320373006273 substrate binding site [chemical binding]; other site 320373006274 catalytic residues [active] 320373006275 dimer interface [polypeptide binding]; other site 320373006276 lysophospholipid transporter LplT; Provisional; Region: PRK11195 320373006277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373006278 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 320373006279 dimer interface [polypeptide binding]; other site 320373006280 substrate binding site [chemical binding]; other site 320373006281 ATP binding site [chemical binding]; other site 320373006282 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 320373006283 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 320373006284 Fe-S cluster binding site [ion binding]; other site 320373006285 active site 320373006286 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 320373006287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373006288 Coenzyme A binding pocket [chemical binding]; other site 320373006289 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 320373006290 Glycoprotease family; Region: Peptidase_M22; pfam00814 320373006291 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 320373006292 acyl-CoA binding pocket [chemical binding]; other site 320373006293 CoA binding site [chemical binding]; other site 320373006294 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 320373006295 DEAD-like helicases superfamily; Region: DEXDc; smart00487 320373006296 ATP binding site [chemical binding]; other site 320373006297 Mg++ binding site [ion binding]; other site 320373006298 motif III; other site 320373006299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373006300 nucleotide binding region [chemical binding]; other site 320373006301 ATP-binding site [chemical binding]; other site 320373006302 isocitrate lyase; Provisional; Region: PRK15063 320373006303 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 320373006304 tetramer interface [polypeptide binding]; other site 320373006305 active site 320373006306 Mg2+/Mn2+ binding site [ion binding]; other site 320373006307 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373006308 Ligand Binding Site [chemical binding]; other site 320373006309 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373006310 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373006311 putative effector binding pocket; other site 320373006312 dimerization interface [polypeptide binding]; other site 320373006313 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 320373006314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373006315 motif II; other site 320373006316 malate synthase A; Region: malate_syn_A; TIGR01344 320373006317 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 320373006318 active site 320373006319 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 320373006320 putative active site pocket [active] 320373006321 dimerization interface [polypeptide binding]; other site 320373006322 putative catalytic residue [active] 320373006323 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 320373006324 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320373006325 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320373006326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373006327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373006328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373006329 Coenzyme A binding pocket [chemical binding]; other site 320373006330 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 320373006331 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 320373006332 active site 320373006333 HIGH motif; other site 320373006334 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 320373006335 active site 320373006336 KMSKS motif; other site 320373006337 hypothetical protein; Provisional; Region: PRK10279 320373006338 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 320373006339 nucleophile elbow; other site 320373006340 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 320373006341 NlpC/P60 family; Region: NLPC_P60; pfam00877 320373006342 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 320373006343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373006344 Walker A/P-loop; other site 320373006345 ATP binding site [chemical binding]; other site 320373006346 Q-loop/lid; other site 320373006347 ABC transporter signature motif; other site 320373006348 Walker B; other site 320373006349 D-loop; other site 320373006350 H-loop/switch region; other site 320373006351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320373006352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373006353 Walker A/P-loop; other site 320373006354 ATP binding site [chemical binding]; other site 320373006355 Q-loop/lid; other site 320373006356 ABC transporter signature motif; other site 320373006357 Walker B; other site 320373006358 D-loop; other site 320373006359 H-loop/switch region; other site 320373006360 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320373006361 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 320373006362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373006363 dimer interface [polypeptide binding]; other site 320373006364 conserved gate region; other site 320373006365 putative PBP binding loops; other site 320373006366 ABC-ATPase subunit interface; other site 320373006367 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 320373006368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373006369 dimer interface [polypeptide binding]; other site 320373006370 conserved gate region; other site 320373006371 putative PBP binding loops; other site 320373006372 ABC-ATPase subunit interface; other site 320373006373 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 320373006374 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 320373006375 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 320373006376 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 320373006377 NAD binding site [chemical binding]; other site 320373006378 homotetramer interface [polypeptide binding]; other site 320373006379 homodimer interface [polypeptide binding]; other site 320373006380 substrate binding site [chemical binding]; other site 320373006381 active site 320373006382 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 320373006383 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 320373006384 putative [Fe4-S4] binding site [ion binding]; other site 320373006385 putative molybdopterin cofactor binding site [chemical binding]; other site 320373006386 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373006387 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 320373006388 putative molybdopterin cofactor binding site; other site 320373006389 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 320373006390 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 320373006391 FAD binding pocket [chemical binding]; other site 320373006392 FAD binding motif [chemical binding]; other site 320373006393 phosphate binding motif [ion binding]; other site 320373006394 beta-alpha-beta structure motif; other site 320373006395 NAD binding pocket [chemical binding]; other site 320373006396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373006397 Radical SAM superfamily; Region: Radical_SAM; pfam04055 320373006398 FeS/SAM binding site; other site 320373006399 Ferredoxin [Energy production and conversion]; Region: COG1146 320373006400 4Fe-4S binding domain; Region: Fer4; cl02805 320373006401 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 320373006402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373006403 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 320373006404 active site 320373006405 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 320373006406 argininosuccinate lyase; Provisional; Region: PRK02186 320373006407 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 320373006408 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 320373006409 active sites [active] 320373006410 tetramer interface [polypeptide binding]; other site 320373006411 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 320373006412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373006413 catalytic residue [active] 320373006414 dimer interface [polypeptide binding]; other site 320373006415 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 320373006416 G1 box; other site 320373006417 GTP/Mg2+ binding site [chemical binding]; other site 320373006418 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 320373006419 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 320373006420 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 320373006421 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 320373006422 Active Sites [active] 320373006423 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320373006424 active site 320373006425 phosphoserine aminotransferase; Provisional; Region: PRK12462 320373006426 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373006427 catalytic residue [active] 320373006428 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320373006429 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 320373006430 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 320373006431 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 320373006432 PYR/PP interface [polypeptide binding]; other site 320373006433 dimer interface [polypeptide binding]; other site 320373006434 TPP binding site [chemical binding]; other site 320373006435 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 320373006436 TPP-binding site [chemical binding]; other site 320373006437 dimer interface [polypeptide binding]; other site 320373006438 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 320373006439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373006440 S-adenosylmethionine binding site [chemical binding]; other site 320373006441 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320373006442 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320373006443 active site 320373006444 iron coordination sites [ion binding]; other site 320373006445 substrate binding pocket [chemical binding]; other site 320373006446 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 320373006447 Condensation domain; Region: Condensation; pfam00668 320373006448 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373006449 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373006450 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373006451 acyl-activating enzyme (AAE) consensus motif; other site 320373006452 AMP binding site [chemical binding]; other site 320373006453 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373006454 Condensation domain; Region: Condensation; pfam00668 320373006455 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 320373006456 Condensation domain; Region: Condensation; pfam00668 320373006457 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373006458 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373006459 acyl-activating enzyme (AAE) consensus motif; other site 320373006460 AMP binding site [chemical binding]; other site 320373006461 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373006462 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 320373006463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 320373006464 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 320373006465 Transmembrane secretion effector; Region: MFS_3; pfam05977 320373006466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373006467 putative substrate translocation pore; other site 320373006468 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373006469 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373006470 acyl-activating enzyme (AAE) consensus motif; other site 320373006471 AMP binding site [chemical binding]; other site 320373006472 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373006473 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 320373006474 ligand-binding site [chemical binding]; other site 320373006475 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 320373006476 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373006477 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373006478 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 320373006479 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 320373006480 active site 320373006481 catalytic triad [active] 320373006482 oxyanion hole [active] 320373006483 Autotransporter beta-domain; Region: Autotransporter; smart00869 320373006484 aspartate kinase; Reviewed; Region: PRK06635 320373006485 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 320373006486 putative nucleotide binding site [chemical binding]; other site 320373006487 putative catalytic residues [active] 320373006488 putative Mg ion binding site [ion binding]; other site 320373006489 putative aspartate binding site [chemical binding]; other site 320373006490 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 320373006491 putative allosteric regulatory site; other site 320373006492 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 320373006493 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 320373006494 Ligand Binding Site [chemical binding]; other site 320373006495 TilS substrate binding domain; Region: TilS; pfam09179 320373006496 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 320373006497 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 320373006498 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 320373006499 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 320373006500 endonuclease III; Region: ENDO3c; smart00478 320373006501 minor groove reading motif; other site 320373006502 helix-hairpin-helix signature motif; other site 320373006503 substrate binding pocket [chemical binding]; other site 320373006504 active site 320373006505 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 320373006506 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 320373006507 active site 320373006508 HIGH motif; other site 320373006509 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 320373006510 KMSKS motif; other site 320373006511 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 320373006512 tRNA binding surface [nucleotide binding]; other site 320373006513 anticodon binding site; other site 320373006514 TPR repeat; Region: TPR_11; pfam13414 320373006515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373006516 binding surface 320373006517 TPR motif; other site 320373006518 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 320373006519 substrate binding site [chemical binding]; other site 320373006520 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 320373006521 substrate binding site [chemical binding]; other site 320373006522 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320373006523 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 320373006524 putative active site [active] 320373006525 putative metal binding site [ion binding]; other site 320373006526 serine O-acetyltransferase; Region: cysE; TIGR01172 320373006527 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 320373006528 trimer interface [polypeptide binding]; other site 320373006529 active site 320373006530 substrate binding site [chemical binding]; other site 320373006531 CoA binding site [chemical binding]; other site 320373006532 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 320373006533 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 320373006534 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 320373006535 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 320373006536 active site 320373006537 dimerization interface [polypeptide binding]; other site 320373006538 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 320373006539 MutS domain I; Region: MutS_I; pfam01624 320373006540 MutS domain II; Region: MutS_II; pfam05188 320373006541 MutS domain III; Region: MutS_III; pfam05192 320373006542 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 320373006543 Walker A/P-loop; other site 320373006544 ATP binding site [chemical binding]; other site 320373006545 Q-loop/lid; other site 320373006546 ABC transporter signature motif; other site 320373006547 Walker B; other site 320373006548 D-loop; other site 320373006549 H-loop/switch region; other site 320373006550 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 320373006551 Uncharacterized conserved protein [Function unknown]; Region: COG2850 320373006552 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 320373006553 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 320373006554 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 320373006555 dihydrodipicolinate synthase; Region: dapA; TIGR00674 320373006556 dimer interface [polypeptide binding]; other site 320373006557 active site 320373006558 catalytic residue [active] 320373006559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320373006560 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 320373006561 active site 320373006562 HIGH motif; other site 320373006563 dimer interface [polypeptide binding]; other site 320373006564 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320373006565 active site 320373006566 KMSKS motif; other site 320373006567 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 320373006568 Peptidase family M50; Region: Peptidase_M50; pfam02163 320373006569 active site 320373006570 putative substrate binding region [chemical binding]; other site 320373006571 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 320373006572 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 320373006573 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 320373006574 active site 320373006575 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 320373006576 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373006577 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373006578 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 320373006579 catalytic site [active] 320373006580 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 320373006581 dinuclear metal binding motif [ion binding]; other site 320373006582 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 320373006583 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 320373006584 trimer interface [polypeptide binding]; other site 320373006585 putative metal binding site [ion binding]; other site 320373006586 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 320373006587 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 320373006588 dimerization interface [polypeptide binding]; other site 320373006589 domain crossover interface; other site 320373006590 redox-dependent activation switch; other site 320373006591 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 320373006592 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 320373006593 enolase; Provisional; Region: eno; PRK00077 320373006594 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 320373006595 dimer interface [polypeptide binding]; other site 320373006596 metal binding site [ion binding]; metal-binding site 320373006597 substrate binding pocket [chemical binding]; other site 320373006598 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 320373006599 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 320373006600 CTP synthetase; Validated; Region: pyrG; PRK05380 320373006601 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 320373006602 Catalytic site [active] 320373006603 active site 320373006604 UTP binding site [chemical binding]; other site 320373006605 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 320373006606 active site 320373006607 putative oxyanion hole; other site 320373006608 catalytic triad [active] 320373006609 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373006610 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 320373006611 nucleophilic elbow; other site 320373006612 catalytic triad; other site 320373006613 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 320373006614 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 320373006615 Competence protein; Region: Competence; pfam03772 320373006616 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 320373006617 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320373006618 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 320373006619 active site 320373006620 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 320373006621 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320373006622 Walker A/P-loop; other site 320373006623 ATP binding site [chemical binding]; other site 320373006624 Q-loop/lid; other site 320373006625 ABC transporter signature motif; other site 320373006626 Walker B; other site 320373006627 D-loop; other site 320373006628 H-loop/switch region; other site 320373006629 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 320373006630 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 320373006631 FtsX-like permease family; Region: FtsX; pfam02687 320373006632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 320373006633 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 320373006634 DHH family; Region: DHH; pfam01368 320373006635 DHHA1 domain; Region: DHHA1; pfam02272 320373006636 peptide chain release factor 2; Validated; Region: prfB; PRK00578 320373006637 This domain is found in peptide chain release factors; Region: PCRF; smart00937 320373006638 RF-1 domain; Region: RF-1; pfam00472 320373006639 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 320373006640 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 320373006641 dimer interface [polypeptide binding]; other site 320373006642 putative anticodon binding site; other site 320373006643 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 320373006644 motif 1; other site 320373006645 active site 320373006646 motif 2; other site 320373006647 motif 3; other site 320373006648 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 320373006649 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 320373006650 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373006651 catalytic loop [active] 320373006652 iron binding site [ion binding]; other site 320373006653 chaperone protein HscA; Provisional; Region: hscA; PRK05183 320373006654 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 320373006655 nucleotide binding site [chemical binding]; other site 320373006656 putative NEF/HSP70 interaction site [polypeptide binding]; other site 320373006657 SBD interface [polypeptide binding]; other site 320373006658 co-chaperone HscB; Provisional; Region: hscB; PRK03578 320373006659 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 320373006660 HSP70 interaction site [polypeptide binding]; other site 320373006661 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 320373006662 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 320373006663 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 320373006664 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 320373006665 trimerization site [polypeptide binding]; other site 320373006666 active site 320373006667 cysteine desulfurase; Provisional; Region: PRK14012 320373006668 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 320373006669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373006670 catalytic residue [active] 320373006671 Predicted transcriptional regulator [Transcription]; Region: COG1959 320373006672 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 320373006673 Low molecular weight phosphatase family; Region: LMWPc; cd00115 320373006674 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 320373006675 active site 320373006676 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 320373006677 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 320373006678 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 320373006679 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 320373006680 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 320373006681 Cysteine-rich domain; Region: CCG; pfam02754 320373006682 Cysteine-rich domain; Region: CCG; pfam02754 320373006683 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320373006684 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373006685 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373006686 Transposase domain (DUF772); Region: DUF772; pfam05598 320373006687 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320373006688 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320373006689 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 320373006690 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320373006691 Phasin protein; Region: Phasin_2; pfam09361 320373006692 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320373006693 E3 interaction surface; other site 320373006694 lipoyl attachment site [posttranslational modification]; other site 320373006695 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 320373006696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373006697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373006698 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320373006699 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 320373006700 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320373006701 E3 interaction surface; other site 320373006702 lipoyl attachment site [posttranslational modification]; other site 320373006703 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320373006704 E3 interaction surface; other site 320373006705 lipoyl attachment site [posttranslational modification]; other site 320373006706 e3 binding domain; Region: E3_binding; pfam02817 320373006707 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 320373006708 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 320373006709 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 320373006710 dimer interface [polypeptide binding]; other site 320373006711 TPP-binding site [chemical binding]; other site 320373006712 PAS domain S-box; Region: sensory_box; TIGR00229 320373006713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373006714 putative active site [active] 320373006715 heme pocket [chemical binding]; other site 320373006716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373006717 dimer interface [polypeptide binding]; other site 320373006718 phosphorylation site [posttranslational modification] 320373006719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373006720 ATP binding site [chemical binding]; other site 320373006721 Mg2+ binding site [ion binding]; other site 320373006722 G-X-G motif; other site 320373006723 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 320373006724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373006725 active site 320373006726 phosphorylation site [posttranslational modification] 320373006727 intermolecular recognition site; other site 320373006728 dimerization interface [polypeptide binding]; other site 320373006729 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373006730 DNA binding residues [nucleotide binding] 320373006731 dimerization interface [polypeptide binding]; other site 320373006732 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 320373006733 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 320373006734 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 320373006735 homodimer interface [polypeptide binding]; other site 320373006736 NADP binding site [chemical binding]; other site 320373006737 substrate binding site [chemical binding]; other site 320373006738 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 320373006739 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 320373006740 active site 320373006741 Zn binding site [ion binding]; other site 320373006742 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 320373006743 active site 320373006744 DNA polymerase IV; Validated; Region: PRK02406 320373006745 DNA binding site [nucleotide binding] 320373006746 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 320373006747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373006748 putative substrate translocation pore; other site 320373006749 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 320373006750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373006751 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 320373006752 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 320373006753 [4Fe-4S] binding site [ion binding]; other site 320373006754 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373006755 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373006756 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373006757 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 320373006758 molybdopterin cofactor binding site; other site 320373006759 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 320373006760 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 320373006761 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 320373006762 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 320373006763 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 320373006764 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373006765 dimerization interface [polypeptide binding]; other site 320373006766 GAF domain; Region: GAF; pfam01590 320373006767 Histidine kinase; Region: HisKA_3; pfam07730 320373006768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373006769 ATP binding site [chemical binding]; other site 320373006770 Mg2+ binding site [ion binding]; other site 320373006771 G-X-G motif; other site 320373006772 transcriptional regulator NarL; Provisional; Region: PRK10651 320373006773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373006774 active site 320373006775 phosphorylation site [posttranslational modification] 320373006776 intermolecular recognition site; other site 320373006777 dimerization interface [polypeptide binding]; other site 320373006778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373006779 DNA binding residues [nucleotide binding] 320373006780 dimerization interface [polypeptide binding]; other site 320373006781 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 320373006782 putative catalytic site [active] 320373006783 putative phosphate binding site [ion binding]; other site 320373006784 active site 320373006785 metal binding site A [ion binding]; metal-binding site 320373006786 DNA binding site [nucleotide binding] 320373006787 putative AP binding site [nucleotide binding]; other site 320373006788 putative metal binding site B [ion binding]; other site 320373006789 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 320373006790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373006791 active site 320373006792 phosphorylation site [posttranslational modification] 320373006793 intermolecular recognition site; other site 320373006794 dimerization interface [polypeptide binding]; other site 320373006795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373006796 Walker A motif; other site 320373006797 ATP binding site [chemical binding]; other site 320373006798 Walker B motif; other site 320373006799 arginine finger; other site 320373006800 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373006801 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 320373006802 PAS domain; Region: PAS; smart00091 320373006803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373006804 dimer interface [polypeptide binding]; other site 320373006805 phosphorylation site [posttranslational modification] 320373006806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373006807 ATP binding site [chemical binding]; other site 320373006808 Mg2+ binding site [ion binding]; other site 320373006809 G-X-G motif; other site 320373006810 glutamine synthetase; Provisional; Region: glnA; PRK09469 320373006811 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 320373006812 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 320373006813 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 320373006814 active site residue [active] 320373006815 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 320373006816 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 320373006817 putative MPT binding site; other site 320373006818 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 320373006819 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 320373006820 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 320373006821 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 320373006822 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 320373006823 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 320373006824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320373006825 ATP binding site [chemical binding]; other site 320373006826 putative Mg++ binding site [ion binding]; other site 320373006827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373006828 nucleotide binding region [chemical binding]; other site 320373006829 ATP-binding site [chemical binding]; other site 320373006830 Helicase associated domain (HA2); Region: HA2; pfam04408 320373006831 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 320373006832 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 320373006833 N-acetylglutamate synthase; Validated; Region: PRK05279 320373006834 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 320373006835 putative feedback inhibition sensing region; other site 320373006836 putative nucleotide binding site [chemical binding]; other site 320373006837 putative substrate binding site [chemical binding]; other site 320373006838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373006839 Coenzyme A binding pocket [chemical binding]; other site 320373006840 oxidative damage protection protein; Provisional; Region: PRK05408 320373006841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373006842 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373006843 putative substrate translocation pore; other site 320373006844 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320373006845 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320373006846 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373006847 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373006848 active site 320373006849 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 320373006850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373006851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373006852 dimerization interface [polypeptide binding]; other site 320373006853 putative aminotransferase; Validated; Region: PRK07480 320373006854 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373006855 inhibitor-cofactor binding pocket; inhibition site 320373006856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373006857 catalytic residue [active] 320373006858 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 320373006859 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 320373006860 Peptidase C26; Region: Peptidase_C26; pfam07722 320373006861 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 320373006862 catalytic triad [active] 320373006863 N-formylglutamate amidohydrolase; Region: FGase; cl01522 320373006864 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 320373006865 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320373006866 active site 320373006867 imidazolonepropionase; Validated; Region: PRK09356 320373006868 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 320373006869 active site 320373006870 HutD; Region: HutD; pfam05962 320373006871 urocanate hydratase; Provisional; Region: PRK05414 320373006872 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 320373006873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373006874 DNA-binding site [nucleotide binding]; DNA binding site 320373006875 UTRA domain; Region: UTRA; pfam07702 320373006876 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 320373006877 active sites [active] 320373006878 tetramer interface [polypeptide binding]; other site 320373006879 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 320373006880 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 320373006881 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 320373006882 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320373006883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373006884 DNA binding residues [nucleotide binding] 320373006885 dimerization interface [polypeptide binding]; other site 320373006886 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 320373006887 ligand-binding site [chemical binding]; other site 320373006888 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 320373006889 DNA photolyase; Region: DNA_photolyase; pfam00875 320373006890 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 320373006891 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320373006892 Di-iron ligands [ion binding]; other site 320373006893 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 320373006894 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 320373006895 NnrS protein; Region: NnrS; pfam05940 320373006896 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 320373006897 Class III ribonucleotide reductase; Region: RNR_III; cd01675 320373006898 effector binding site; other site 320373006899 active site 320373006900 Zn binding site [ion binding]; other site 320373006901 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 320373006902 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 320373006903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373006904 FeS/SAM binding site; other site 320373006905 DGC domain; Region: DGC; pfam08859 320373006906 SCP-2 sterol transfer family; Region: SCP2; cl01225 320373006907 putative protease; Provisional; Region: PRK15447 320373006908 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 320373006909 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 320373006910 Peptidase family U32; Region: Peptidase_U32; pfam01136 320373006911 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 320373006912 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 320373006913 FMN binding site [chemical binding]; other site 320373006914 substrate binding site [chemical binding]; other site 320373006915 putative catalytic residue [active] 320373006916 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320373006917 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320373006918 ligand binding site [chemical binding]; other site 320373006919 flexible hinge region; other site 320373006920 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 320373006921 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 320373006922 HemN C-terminal domain; Region: HemN_C; pfam06969 320373006923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373006924 dimerization interface [polypeptide binding]; other site 320373006925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373006926 dimer interface [polypeptide binding]; other site 320373006927 putative CheW interface [polypeptide binding]; other site 320373006928 NnrS protein; Region: NnrS; pfam05940 320373006929 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 320373006930 putative ABC transporter; Region: ycf24; CHL00085 320373006931 FeS assembly ATPase SufC; Region: sufC; TIGR01978 320373006932 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 320373006933 Walker A/P-loop; other site 320373006934 ATP binding site [chemical binding]; other site 320373006935 Q-loop/lid; other site 320373006936 ABC transporter signature motif; other site 320373006937 Walker B; other site 320373006938 D-loop; other site 320373006939 H-loop/switch region; other site 320373006940 FeS assembly protein SufD; Region: sufD; TIGR01981 320373006941 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 320373006942 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 320373006943 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 320373006944 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373006945 catalytic residue [active] 320373006946 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 320373006947 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 320373006948 trimerization site [polypeptide binding]; other site 320373006949 active site 320373006950 Domain of unknown function DUF59; Region: DUF59; cl00941 320373006951 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 320373006952 Transcriptional regulator; Region: Rrf2; cl17282 320373006953 Rrf2 family protein; Region: rrf2_super; TIGR00738 320373006954 Hemerythrin; Region: Hemerythrin; cd12107 320373006955 Fe binding site [ion binding]; other site 320373006956 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 320373006957 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320373006958 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 320373006959 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 320373006960 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 320373006961 D-pathway; other site 320373006962 Putative ubiquinol binding site [chemical binding]; other site 320373006963 Low-spin heme (heme b) binding site [chemical binding]; other site 320373006964 Putative water exit pathway; other site 320373006965 Binuclear center (heme o3/CuB) [ion binding]; other site 320373006966 K-pathway; other site 320373006967 Putative proton exit pathway; other site 320373006968 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 320373006969 Subunit I/III interface [polypeptide binding]; other site 320373006970 Subunit III/IV interface [polypeptide binding]; other site 320373006971 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 320373006972 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 320373006973 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320373006974 putative di-iron ligands [ion binding]; other site 320373006975 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 320373006976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373006977 substrate binding pocket [chemical binding]; other site 320373006978 membrane-bound complex binding site; other site 320373006979 hinge residues; other site 320373006980 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 320373006981 dimer interface [polypeptide binding]; other site 320373006982 N-terminal domain interface [polypeptide binding]; other site 320373006983 substrate binding pocket (H-site) [chemical binding]; other site 320373006984 succinylglutamate desuccinylase; Provisional; Region: PRK05324 320373006985 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 320373006986 active site 320373006987 Zn binding site [ion binding]; other site 320373006988 succinylarginine dihydrolase; Provisional; Region: PRK13281 320373006989 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 320373006990 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 320373006991 NAD(P) binding site [chemical binding]; other site 320373006992 catalytic residues [active] 320373006993 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 320373006994 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 320373006995 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 320373006996 arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245 320373006997 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 320373006998 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373006999 inhibitor-cofactor binding pocket; inhibition site 320373007000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373007001 catalytic residue [active] 320373007002 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320373007003 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 320373007004 conserved cys residue [active] 320373007005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373007006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373007007 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 320373007008 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320373007009 Walker A/P-loop; other site 320373007010 ATP binding site [chemical binding]; other site 320373007011 Q-loop/lid; other site 320373007012 ABC transporter signature motif; other site 320373007013 Walker B; other site 320373007014 D-loop; other site 320373007015 H-loop/switch region; other site 320373007016 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320373007017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373007018 dimer interface [polypeptide binding]; other site 320373007019 conserved gate region; other site 320373007020 putative PBP binding loops; other site 320373007021 ABC-ATPase subunit interface; other site 320373007022 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320373007023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373007024 dimer interface [polypeptide binding]; other site 320373007025 conserved gate region; other site 320373007026 putative PBP binding loops; other site 320373007027 ABC-ATPase subunit interface; other site 320373007028 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 320373007029 putative membrane protein; Region: HpnL; TIGR03476 320373007030 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 320373007031 putative active site [active] 320373007032 YdjC motif; other site 320373007033 Mg binding site [ion binding]; other site 320373007034 putative homodimer interface [polypeptide binding]; other site 320373007035 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 320373007036 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 320373007037 B12 binding site [chemical binding]; other site 320373007038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373007039 FeS/SAM binding site; other site 320373007040 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 320373007041 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 320373007042 ligand binding site; other site 320373007043 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 320373007044 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 320373007045 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 320373007046 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373007047 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373007048 pyridoxamine kinase; Validated; Region: PRK05756 320373007049 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 320373007050 dimer interface [polypeptide binding]; other site 320373007051 pyridoxal binding site [chemical binding]; other site 320373007052 ATP binding site [chemical binding]; other site 320373007053 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 320373007054 Phosphoesterase family; Region: Phosphoesterase; pfam04185 320373007055 Domain of unknown function (DUF756); Region: DUF756; pfam05506 320373007056 Domain of unknown function (DUF756); Region: DUF756; pfam05506 320373007057 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320373007058 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320373007059 dimerization interface [polypeptide binding]; other site 320373007060 ligand binding site [chemical binding]; other site 320373007061 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 320373007062 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 320373007063 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 320373007064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373007065 putative ADP-binding pocket [chemical binding]; other site 320373007066 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 320373007067 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320373007068 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 320373007069 Walker A/P-loop; other site 320373007070 ATP binding site [chemical binding]; other site 320373007071 Q-loop/lid; other site 320373007072 ABC transporter signature motif; other site 320373007073 Walker B; other site 320373007074 D-loop; other site 320373007075 H-loop/switch region; other site 320373007076 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 320373007077 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 320373007078 active site 320373007079 homotetramer interface [polypeptide binding]; other site 320373007080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373007081 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 320373007082 active site 320373007083 motif I; other site 320373007084 motif II; other site 320373007085 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 320373007086 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320373007087 Cu(I) binding site [ion binding]; other site 320373007088 Protein of unknown function (DUF461); Region: DUF461; pfam04314 320373007089 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 320373007090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373007091 Pirin-related protein [General function prediction only]; Region: COG1741 320373007092 Pirin; Region: Pirin; pfam02678 320373007093 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 320373007094 LysR family transcriptional regulator; Provisional; Region: PRK14997 320373007095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373007096 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 320373007097 putative effector binding pocket; other site 320373007098 putative dimerization interface [polypeptide binding]; other site 320373007099 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 320373007100 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 320373007101 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 320373007102 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 320373007103 GIY-YIG motif/motif A; other site 320373007104 active site 320373007105 catalytic site [active] 320373007106 putative DNA binding site [nucleotide binding]; other site 320373007107 metal binding site [ion binding]; metal-binding site 320373007108 UvrB/uvrC motif; Region: UVR; pfam02151 320373007109 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 320373007110 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 320373007111 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 320373007112 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 320373007113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 320373007114 elongation factor P; Validated; Region: PRK00529 320373007115 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 320373007116 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 320373007117 RNA binding site [nucleotide binding]; other site 320373007118 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 320373007119 RNA binding site [nucleotide binding]; other site 320373007120 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320373007121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373007122 active site 320373007123 phosphorylation site [posttranslational modification] 320373007124 intermolecular recognition site; other site 320373007125 dimerization interface [polypeptide binding]; other site 320373007126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373007127 Walker A motif; other site 320373007128 ATP binding site [chemical binding]; other site 320373007129 Walker B motif; other site 320373007130 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373007131 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 320373007132 beta-hexosaminidase; Provisional; Region: PRK05337 320373007133 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 320373007134 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 320373007135 active site 320373007136 hydrophilic channel; other site 320373007137 dimerization interface [polypeptide binding]; other site 320373007138 catalytic residues [active] 320373007139 active site lid [active] 320373007140 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 320373007141 Recombination protein O N terminal; Region: RecO_N; pfam11967 320373007142 Recombination protein O C terminal; Region: RecO_C; pfam02565 320373007143 GTPase Era; Reviewed; Region: era; PRK00089 320373007144 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 320373007145 G1 box; other site 320373007146 GTP/Mg2+ binding site [chemical binding]; other site 320373007147 Switch I region; other site 320373007148 G2 box; other site 320373007149 Switch II region; other site 320373007150 G3 box; other site 320373007151 G4 box; other site 320373007152 G5 box; other site 320373007153 KH domain; Region: KH_2; pfam07650 320373007154 ribonuclease III; Provisional; Region: PRK14718 320373007155 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 320373007156 dimerization interface [polypeptide binding]; other site 320373007157 active site 320373007158 metal binding site [ion binding]; metal-binding site 320373007159 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 320373007160 signal peptidase I; Provisional; Region: PRK10861 320373007161 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 320373007162 Catalytic site [active] 320373007163 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 320373007164 GTP-binding protein LepA; Provisional; Region: PRK05433 320373007165 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 320373007166 G1 box; other site 320373007167 putative GEF interaction site [polypeptide binding]; other site 320373007168 GTP/Mg2+ binding site [chemical binding]; other site 320373007169 Switch I region; other site 320373007170 G2 box; other site 320373007171 G3 box; other site 320373007172 Switch II region; other site 320373007173 G4 box; other site 320373007174 G5 box; other site 320373007175 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 320373007176 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 320373007177 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 320373007178 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 320373007179 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 320373007180 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 320373007181 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320373007182 protein binding site [polypeptide binding]; other site 320373007183 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320373007184 protein binding site [polypeptide binding]; other site 320373007185 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 320373007186 anti-sigma E factor; Provisional; Region: rseB; PRK09455 320373007187 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 320373007188 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 320373007189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373007190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373007191 DNA binding residues [nucleotide binding] 320373007192 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 320373007193 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 320373007194 dimer interface [polypeptide binding]; other site 320373007195 active site 320373007196 acyl carrier protein; Provisional; Region: acpP; PRK00982 320373007197 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 320373007198 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 320373007199 NAD(P) binding site [chemical binding]; other site 320373007200 homotetramer interface [polypeptide binding]; other site 320373007201 homodimer interface [polypeptide binding]; other site 320373007202 active site 320373007203 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 320373007204 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320373007205 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 320373007206 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 320373007207 dimer interface [polypeptide binding]; other site 320373007208 active site 320373007209 CoA binding pocket [chemical binding]; other site 320373007210 putative phosphate acyltransferase; Provisional; Region: PRK05331 320373007211 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 320373007212 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 320373007213 Maf-like protein; Region: Maf; pfam02545 320373007214 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 320373007215 active site 320373007216 dimer interface [polypeptide binding]; other site 320373007217 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 320373007218 putative SAM binding site [chemical binding]; other site 320373007219 homodimer interface [polypeptide binding]; other site 320373007220 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 320373007221 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 320373007222 tandem repeat interface [polypeptide binding]; other site 320373007223 oligomer interface [polypeptide binding]; other site 320373007224 active site residues [active] 320373007225 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 320373007226 iron-sulfur cluster [ion binding]; other site 320373007227 [2Fe-2S] cluster binding site [ion binding]; other site 320373007228 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 320373007229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373007230 motif II; other site 320373007231 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 320373007232 S4 domain; Region: S4; pfam01479 320373007233 RNA binding surface [nucleotide binding]; other site 320373007234 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 320373007235 active site 320373007236 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 320373007237 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 320373007238 homodimer interface [polypeptide binding]; other site 320373007239 oligonucleotide binding site [chemical binding]; other site 320373007240 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 320373007241 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373007242 FeS/SAM binding site; other site 320373007243 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 320373007244 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 320373007245 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 320373007246 GTP binding site; other site 320373007247 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 320373007248 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 320373007249 dimer interface [polypeptide binding]; other site 320373007250 putative functional site; other site 320373007251 putative MPT binding site; other site 320373007252 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320373007253 RmuC family; Region: RmuC; pfam02646 320373007254 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 320373007255 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 320373007256 dimerization interface [polypeptide binding]; other site 320373007257 ligand binding site [chemical binding]; other site 320373007258 NADP binding site [chemical binding]; other site 320373007259 catalytic site [active] 320373007260 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 320373007261 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 320373007262 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 320373007263 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 320373007264 active site 320373007265 Ferredoxin [Energy production and conversion]; Region: COG1146 320373007266 4Fe-4S binding domain; Region: Fer4; cl02805 320373007267 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 320373007268 Transposase domain (DUF772); Region: DUF772; pfam05598 320373007269 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320373007270 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320373007271 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320373007272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 320373007273 CreA protein; Region: CreA; pfam05981 320373007274 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 320373007275 S4 domain; Region: S4_2; pfam13275 320373007276 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 320373007277 multidrug efflux protein; Reviewed; Region: PRK01766 320373007278 cation binding site [ion binding]; other site 320373007279 fumarate hydratase; Reviewed; Region: fumC; PRK00485 320373007280 Class II fumarases; Region: Fumarase_classII; cd01362 320373007281 active site 320373007282 tetramer interface [polypeptide binding]; other site 320373007283 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 320373007284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373007285 dimerization interface [polypeptide binding]; other site 320373007286 putative DNA binding site [nucleotide binding]; other site 320373007287 putative Zn2+ binding site [ion binding]; other site 320373007288 FecR protein; Region: FecR; pfam04773 320373007289 thymidylate synthase; Provisional; Region: thyA; PRK13821 320373007290 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 320373007291 dimerization interface [polypeptide binding]; other site 320373007292 active site 320373007293 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320373007294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373007295 Walker A motif; other site 320373007296 ATP binding site [chemical binding]; other site 320373007297 Walker B motif; other site 320373007298 arginine finger; other site 320373007299 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373007300 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320373007301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373007302 Walker A motif; other site 320373007303 ATP binding site [chemical binding]; other site 320373007304 Walker B motif; other site 320373007305 arginine finger; other site 320373007306 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 320373007307 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 320373007308 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 320373007309 folate binding site [chemical binding]; other site 320373007310 NADP+ binding site [chemical binding]; other site 320373007311 Transposase domain (DUF772); Region: DUF772; pfam05598 320373007312 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320373007313 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320373007314 peptidase PmbA; Provisional; Region: PRK11040 320373007315 hypothetical protein; Provisional; Region: PRK05255 320373007316 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 320373007317 MPT binding site; other site 320373007318 trimer interface [polypeptide binding]; other site 320373007319 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 320373007320 catalytic site [active] 320373007321 putative active site [active] 320373007322 putative substrate binding site [chemical binding]; other site 320373007323 dimer interface [polypeptide binding]; other site 320373007324 Peptidase family M48; Region: Peptidase_M48; pfam01435 320373007325 GTPase RsgA; Reviewed; Region: PRK00098 320373007326 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 320373007327 RNA binding site [nucleotide binding]; other site 320373007328 homodimer interface [polypeptide binding]; other site 320373007329 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 320373007330 GTPase/Zn-binding domain interface [polypeptide binding]; other site 320373007331 GTP/Mg2+ binding site [chemical binding]; other site 320373007332 G4 box; other site 320373007333 G5 box; other site 320373007334 G1 box; other site 320373007335 Switch I region; other site 320373007336 G2 box; other site 320373007337 G3 box; other site 320373007338 Switch II region; other site 320373007339 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 320373007340 CobD/CbiB family protein; Provisional; Region: PRK07630 320373007341 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 320373007342 putative active site [active] 320373007343 putative CoA binding site [chemical binding]; other site 320373007344 nudix motif; other site 320373007345 metal binding site [ion binding]; metal-binding site 320373007346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373007347 Coenzyme A binding pocket [chemical binding]; other site 320373007348 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 320373007349 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 320373007350 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 320373007351 RimM N-terminal domain; Region: RimM; pfam01782 320373007352 PRC-barrel domain; Region: PRC; pfam05239 320373007353 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 320373007354 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 320373007355 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 320373007356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373007357 FeS/SAM binding site; other site 320373007358 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 320373007359 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 320373007360 AsnC family; Region: AsnC_trans_reg; pfam01037 320373007361 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 320373007362 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373007363 hydroxyglutarate oxidase; Provisional; Region: PRK11728 320373007364 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 320373007365 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 320373007366 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373007367 active site 320373007368 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 320373007369 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 320373007370 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 320373007371 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 320373007372 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 320373007373 Ligand binding site [chemical binding]; other site 320373007374 Electron transfer flavoprotein domain; Region: ETF; pfam01012 320373007375 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 320373007376 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 320373007377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373007378 dimer interface [polypeptide binding]; other site 320373007379 conserved gate region; other site 320373007380 ABC-ATPase subunit interface; other site 320373007381 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 320373007382 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 320373007383 Walker A/P-loop; other site 320373007384 ATP binding site [chemical binding]; other site 320373007385 Q-loop/lid; other site 320373007386 ABC transporter signature motif; other site 320373007387 Walker B; other site 320373007388 D-loop; other site 320373007389 H-loop/switch region; other site 320373007390 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 320373007391 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 320373007392 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373007393 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320373007394 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 320373007395 putative active site [active] 320373007396 Zn binding site [ion binding]; other site 320373007397 Transglycosylase SLT domain; Region: SLT_2; pfam13406 320373007398 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320373007399 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320373007400 catalytic residue [active] 320373007401 cysteine synthase B; Region: cysM; TIGR01138 320373007402 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 320373007403 dimer interface [polypeptide binding]; other site 320373007404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373007405 catalytic residue [active] 320373007406 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 320373007407 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 320373007408 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 320373007409 NADP binding site [chemical binding]; other site 320373007410 homopentamer interface [polypeptide binding]; other site 320373007411 substrate binding site [chemical binding]; other site 320373007412 active site 320373007413 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 320373007414 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320373007415 putative ribose interaction site [chemical binding]; other site 320373007416 putative ADP binding site [chemical binding]; other site 320373007417 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 320373007418 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 320373007419 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 320373007420 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 320373007421 tetratricopeptide repeat protein; Provisional; Region: PRK11788 320373007422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373007423 binding surface 320373007424 TPR motif; other site 320373007425 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 320373007426 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 320373007427 IHF dimer interface [polypeptide binding]; other site 320373007428 IHF - DNA interface [nucleotide binding]; other site 320373007429 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 320373007430 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 320373007431 RNA binding site [nucleotide binding]; other site 320373007432 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 320373007433 RNA binding site [nucleotide binding]; other site 320373007434 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 320373007435 RNA binding site [nucleotide binding]; other site 320373007436 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 320373007437 RNA binding site [nucleotide binding]; other site 320373007438 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 320373007439 RNA binding site [nucleotide binding]; other site 320373007440 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 320373007441 RNA binding site [nucleotide binding]; other site 320373007442 cytidylate kinase; Provisional; Region: cmk; PRK00023 320373007443 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 320373007444 CMP-binding site; other site 320373007445 The sites determining sugar specificity; other site 320373007446 bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK11861 320373007447 prephenate dehydrogenase; Validated; Region: PRK08507 320373007448 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 320373007449 hinge; other site 320373007450 active site 320373007451 Chorismate mutase type II; Region: CM_2; smart00830 320373007452 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 320373007453 Prephenate dehydratase; Region: PDT; pfam00800 320373007454 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 320373007455 putative L-Phe binding site [chemical binding]; other site 320373007456 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 320373007457 homodimer interface [polypeptide binding]; other site 320373007458 substrate-cofactor binding pocket; other site 320373007459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373007460 catalytic residue [active] 320373007461 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 320373007462 DNA gyrase subunit A; Validated; Region: PRK05560 320373007463 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 320373007464 CAP-like domain; other site 320373007465 active site 320373007466 primary dimer interface [polypeptide binding]; other site 320373007467 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320373007468 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320373007469 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320373007470 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320373007471 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320373007472 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 320373007473 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373007474 ligand binding site [chemical binding]; other site 320373007475 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 320373007476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373007477 S-adenosylmethionine binding site [chemical binding]; other site 320373007478 phosphoglycolate phosphatase; Provisional; Region: PRK13226 320373007479 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373007480 motif II; other site 320373007481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373007482 S-adenosylmethionine binding site [chemical binding]; other site 320373007483 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 320373007484 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 320373007485 PBP superfamily domain; Region: PBP_like; pfam12727 320373007486 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 320373007487 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 320373007488 putative dimer interface [polypeptide binding]; other site 320373007489 [2Fe-2S] cluster binding site [ion binding]; other site 320373007490 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 320373007491 putative dimer interface [polypeptide binding]; other site 320373007492 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 320373007493 SLBB domain; Region: SLBB; pfam10531 320373007494 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 320373007495 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 320373007496 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373007497 catalytic loop [active] 320373007498 iron binding site [ion binding]; other site 320373007499 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 320373007500 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 320373007501 [4Fe-4S] binding site [ion binding]; other site 320373007502 molybdopterin cofactor binding site; other site 320373007503 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 320373007504 molybdopterin cofactor binding site; other site 320373007505 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 320373007506 hypothetical protein; Provisional; Region: PRK06184 320373007507 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320373007508 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 320373007509 TPR repeat; Region: TPR_11; pfam13414 320373007510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373007511 binding surface 320373007512 TPR motif; other site 320373007513 TPR repeat; Region: TPR_11; pfam13414 320373007514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373007515 TPR repeat; Region: TPR_11; pfam13414 320373007516 TPR motif; other site 320373007517 binding surface 320373007518 TPR repeat; Region: TPR_11; pfam13414 320373007519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373007520 binding surface 320373007521 TPR motif; other site 320373007522 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373007523 citrate-proton symporter; Provisional; Region: PRK15075 320373007524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373007525 putative substrate translocation pore; other site 320373007526 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 320373007527 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 320373007528 catalytic triad [active] 320373007529 amidase; Provisional; Region: PRK07056 320373007530 Amidase; Region: Amidase; cl11426 320373007531 disulfide bond formation protein B; Provisional; Region: PRK02110 320373007532 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 320373007533 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 320373007534 XdhC Rossmann domain; Region: XdhC_C; pfam13478 320373007535 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 320373007536 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 320373007537 active site 320373007538 purine riboside binding site [chemical binding]; other site 320373007539 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 320373007540 guanine deaminase; Provisional; Region: PRK09228 320373007541 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320373007542 active site 320373007543 Predicted membrane protein [Function unknown]; Region: COG2119 320373007544 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 320373007545 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 320373007546 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 320373007547 aminopeptidase N; Provisional; Region: pepN; PRK14015 320373007548 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 320373007549 active site 320373007550 Zn binding site [ion binding]; other site 320373007551 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 320373007552 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 320373007553 THF binding site; other site 320373007554 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 320373007555 substrate binding site [chemical binding]; other site 320373007556 THF binding site; other site 320373007557 zinc-binding site [ion binding]; other site 320373007558 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 320373007559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373007560 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 320373007561 putative dimerization interface [polypeptide binding]; other site 320373007562 fructose-1,6-bisphosphatase family protein; Region: PLN02628 320373007563 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 320373007564 AMP binding site [chemical binding]; other site 320373007565 metal binding site [ion binding]; metal-binding site 320373007566 active site 320373007567 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 320373007568 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320373007569 catalytic residues [active] 320373007570 BNR repeat-like domain; Region: BNR_2; pfam13088 320373007571 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 320373007572 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373007573 N-terminal plug; other site 320373007574 ligand-binding site [chemical binding]; other site 320373007575 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 320373007576 chorismate mutase; Provisional; Region: PRK09269 320373007577 Chorismate mutase type II; Region: CM_2; cl00693 320373007578 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 320373007579 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 320373007580 active site 320373007581 catalytic site [active] 320373007582 substrate binding site [chemical binding]; other site 320373007583 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 320373007584 GIY-YIG motif/motif A; other site 320373007585 active site 320373007586 catalytic site [active] 320373007587 putative DNA binding site [nucleotide binding]; other site 320373007588 metal binding site [ion binding]; metal-binding site 320373007589 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 320373007590 DNA-binding site [nucleotide binding]; DNA binding site 320373007591 RNA-binding motif; other site 320373007592 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373007593 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373007594 trimer interface [polypeptide binding]; other site 320373007595 eyelet of channel; other site 320373007596 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 320373007597 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 320373007598 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 320373007599 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 320373007600 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320373007601 Zn2+ binding site [ion binding]; other site 320373007602 Mg2+ binding site [ion binding]; other site 320373007603 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 320373007604 synthetase active site [active] 320373007605 NTP binding site [chemical binding]; other site 320373007606 metal binding site [ion binding]; metal-binding site 320373007607 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 320373007608 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 320373007609 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 320373007610 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 320373007611 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 320373007612 catalytic site [active] 320373007613 G-X2-G-X-G-K; other site 320373007614 hypothetical protein; Provisional; Region: PRK11820 320373007615 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 320373007616 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 320373007617 ribonuclease PH; Reviewed; Region: rph; PRK00173 320373007618 Ribonuclease PH; Region: RNase_PH_bact; cd11362 320373007619 hexamer interface [polypeptide binding]; other site 320373007620 active site 320373007621 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 320373007622 active site 320373007623 dimerization interface [polypeptide binding]; other site 320373007624 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 320373007625 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373007626 FeS/SAM binding site; other site 320373007627 HemN C-terminal domain; Region: HemN_C; pfam06969 320373007628 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 320373007629 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373007630 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 320373007631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373007632 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373007633 putative substrate translocation pore; other site 320373007634 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320373007635 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373007636 putative active site [active] 320373007637 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 320373007638 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 320373007639 putative ion selectivity filter; other site 320373007640 putative pore gating glutamate residue; other site 320373007641 putative H+/Cl- coupling transport residue; other site 320373007642 cell division topological specificity factor MinE; Provisional; Region: PRK13989 320373007643 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 320373007644 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 320373007645 Switch I; other site 320373007646 Switch II; other site 320373007647 septum formation inhibitor; Reviewed; Region: PRK01973 320373007648 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 320373007649 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 320373007650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373007651 Coenzyme A binding pocket [chemical binding]; other site 320373007652 LexA regulated protein; Provisional; Region: PRK11675 320373007653 Replication initiation factor; Region: Rep_trans; pfam02486 320373007654 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 320373007655 Zonular occludens toxin (Zot); Region: Zot; cl17485 320373007656 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 320373007657 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373007658 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 320373007659 multiple promoter invertase; Provisional; Region: mpi; PRK13413 320373007660 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 320373007661 catalytic residues [active] 320373007662 catalytic nucleophile [active] 320373007663 Presynaptic Site I dimer interface [polypeptide binding]; other site 320373007664 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 320373007665 Synaptic Flat tetramer interface [polypeptide binding]; other site 320373007666 Synaptic Site I dimer interface [polypeptide binding]; other site 320373007667 DNA binding site [nucleotide binding] 320373007668 seryl-tRNA synthetase; Provisional; Region: PRK05431 320373007669 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 320373007670 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 320373007671 dimer interface [polypeptide binding]; other site 320373007672 active site 320373007673 motif 1; other site 320373007674 motif 2; other site 320373007675 motif 3; other site 320373007676 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 320373007677 recombination factor protein RarA; Reviewed; Region: PRK13342 320373007678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373007679 Walker A motif; other site 320373007680 ATP binding site [chemical binding]; other site 320373007681 Walker B motif; other site 320373007682 arginine finger; other site 320373007683 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 320373007684 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 320373007685 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 320373007686 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 320373007687 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 320373007688 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 320373007689 thioredoxin reductase; Provisional; Region: PRK10262 320373007690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373007691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 320373007692 Smr domain; Region: Smr; pfam01713 320373007693 Predicted membrane protein [Function unknown]; Region: COG2860 320373007694 UPF0126 domain; Region: UPF0126; pfam03458 320373007695 UPF0126 domain; Region: UPF0126; pfam03458 320373007696 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 320373007697 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 320373007698 Walker A/P-loop; other site 320373007699 ATP binding site [chemical binding]; other site 320373007700 Q-loop/lid; other site 320373007701 ABC transporter signature motif; other site 320373007702 Walker B; other site 320373007703 D-loop; other site 320373007704 H-loop/switch region; other site 320373007705 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 320373007706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373007707 dimer interface [polypeptide binding]; other site 320373007708 conserved gate region; other site 320373007709 putative PBP binding loops; other site 320373007710 ABC-ATPase subunit interface; other site 320373007711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373007712 dimer interface [polypeptide binding]; other site 320373007713 conserved gate region; other site 320373007714 putative PBP binding loops; other site 320373007715 ABC-ATPase subunit interface; other site 320373007716 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 320373007717 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 320373007718 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 320373007719 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 320373007720 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 320373007721 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 320373007722 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 320373007723 putative active site [active] 320373007724 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 320373007725 glucokinase; Provisional; Region: glk; PRK00292 320373007726 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320373007727 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320373007728 putative active site [active] 320373007729 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320373007730 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373007731 substrate binding pocket [chemical binding]; other site 320373007732 membrane-bound complex binding site; other site 320373007733 hinge residues; other site 320373007734 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320373007735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373007736 dimer interface [polypeptide binding]; other site 320373007737 conserved gate region; other site 320373007738 putative PBP binding loops; other site 320373007739 ABC-ATPase subunit interface; other site 320373007740 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 320373007741 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320373007742 Walker A/P-loop; other site 320373007743 ATP binding site [chemical binding]; other site 320373007744 Q-loop/lid; other site 320373007745 ABC transporter signature motif; other site 320373007746 Walker B; other site 320373007747 D-loop; other site 320373007748 H-loop/switch region; other site 320373007749 D-cysteine desulfhydrase; Validated; Region: PRK03910 320373007750 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 320373007751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373007752 catalytic residue [active] 320373007753 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 320373007754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373007755 putative substrate translocation pore; other site 320373007756 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 320373007757 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373007758 inhibitor-cofactor binding pocket; inhibition site 320373007759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373007760 catalytic residue [active] 320373007761 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 320373007762 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 320373007763 catalytic motif [active] 320373007764 Zn binding site [ion binding]; other site 320373007765 RibD C-terminal domain; Region: RibD_C; cl17279 320373007766 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 320373007767 Lumazine binding domain; Region: Lum_binding; pfam00677 320373007768 Lumazine binding domain; Region: Lum_binding; pfam00677 320373007769 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 320373007770 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 320373007771 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 320373007772 dimerization interface [polypeptide binding]; other site 320373007773 active site 320373007774 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 320373007775 homopentamer interface [polypeptide binding]; other site 320373007776 active site 320373007777 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 320373007778 putative RNA binding site [nucleotide binding]; other site 320373007779 aminotransferase; Validated; Region: PRK07337 320373007780 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373007781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373007782 homodimer interface [polypeptide binding]; other site 320373007783 catalytic residue [active] 320373007784 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 320373007785 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320373007786 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320373007787 catalytic residue [active] 320373007788 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 320373007789 LysE type translocator; Region: LysE; cl00565 320373007790 serine racemase; Region: PLN02970 320373007791 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 320373007792 tetramer interface [polypeptide binding]; other site 320373007793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373007794 catalytic residue [active] 320373007795 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 320373007796 Rossmann-like domain; Region: Rossmann-like; pfam10727 320373007797 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 320373007798 YGGT family; Region: YGGT; pfam02325 320373007799 YGGT family; Region: YGGT; pfam02325 320373007800 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 320373007801 chromosome condensation membrane protein; Provisional; Region: PRK14196 320373007802 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 320373007803 active site 320373007804 catalytic triad [active] 320373007805 calcium binding site [ion binding]; other site 320373007806 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373007807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373007808 S-adenosylmethionine binding site [chemical binding]; other site 320373007809 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 320373007810 Integrase core domain; Region: rve; pfam00665 320373007811 Integrase core domain; Region: rve_3; pfam13683 320373007812 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 320373007813 DEAD-like helicases superfamily; Region: DEXDc; smart00487 320373007814 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 320373007815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 320373007816 nucleotide binding region [chemical binding]; other site 320373007817 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 320373007818 active site 320373007819 catalytic residues [active] 320373007820 DNA binding site [nucleotide binding] 320373007821 Int/Topo IB signature motif; other site 320373007822 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 320373007823 SIR2-like domain; Region: SIR2_2; pfam13289 320373007824 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320373007825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373007826 S-adenosylmethionine binding site [chemical binding]; other site 320373007827 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 320373007828 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 320373007829 Flagellin N-methylase; Region: FliB; pfam03692 320373007830 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 320373007831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373007832 FeS/SAM binding site; other site 320373007833 HemN C-terminal domain; Region: HemN_C; pfam06969 320373007834 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 320373007835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320373007836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373007837 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 320373007838 active site residue [active] 320373007839 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 320373007840 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373007841 inhibitor-cofactor binding pocket; inhibition site 320373007842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373007843 catalytic residue [active] 320373007844 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 320373007845 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 320373007846 putative ligand binding site [chemical binding]; other site 320373007847 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320373007848 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373007849 TM-ABC transporter signature motif; other site 320373007850 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320373007851 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320373007852 TM-ABC transporter signature motif; other site 320373007853 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 320373007854 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320373007855 Walker A/P-loop; other site 320373007856 ATP binding site [chemical binding]; other site 320373007857 Q-loop/lid; other site 320373007858 ABC transporter signature motif; other site 320373007859 Walker B; other site 320373007860 D-loop; other site 320373007861 H-loop/switch region; other site 320373007862 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 320373007863 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320373007864 Walker A/P-loop; other site 320373007865 ATP binding site [chemical binding]; other site 320373007866 Q-loop/lid; other site 320373007867 ABC transporter signature motif; other site 320373007868 Walker B; other site 320373007869 D-loop; other site 320373007870 H-loop/switch region; other site 320373007871 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 320373007872 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 320373007873 alpha-gamma subunit interface [polypeptide binding]; other site 320373007874 beta-gamma subunit interface [polypeptide binding]; other site 320373007875 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 320373007876 gamma-beta subunit interface [polypeptide binding]; other site 320373007877 alpha-beta subunit interface [polypeptide binding]; other site 320373007878 urease subunit alpha; Reviewed; Region: ureC; PRK13207 320373007879 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 320373007880 subunit interactions [polypeptide binding]; other site 320373007881 active site 320373007882 flap region; other site 320373007883 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 320373007884 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 320373007885 dimer interface [polypeptide binding]; other site 320373007886 catalytic residues [active] 320373007887 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 320373007888 UreF; Region: UreF; pfam01730 320373007889 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 320373007890 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 320373007891 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 320373007892 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373007893 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 320373007894 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320373007895 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373007896 putative active site [active] 320373007897 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 320373007898 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 320373007899 active site 320373007900 substrate binding site [chemical binding]; other site 320373007901 metal binding site [ion binding]; metal-binding site 320373007902 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 320373007903 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 320373007904 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 320373007905 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320373007906 active site 320373007907 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 320373007908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373007909 putative ADP-binding pocket [chemical binding]; other site 320373007910 UDP-glucose 4-epimerase; Region: PLN02240 320373007911 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 320373007912 NAD binding site [chemical binding]; other site 320373007913 homodimer interface [polypeptide binding]; other site 320373007914 active site 320373007915 substrate binding site [chemical binding]; other site 320373007916 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 320373007917 Mg++ binding site [ion binding]; other site 320373007918 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 320373007919 putative catalytic motif [active] 320373007920 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 320373007921 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 320373007922 NAD(P) binding site [chemical binding]; other site 320373007923 homodimer interface [polypeptide binding]; other site 320373007924 substrate binding site [chemical binding]; other site 320373007925 active site 320373007926 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 320373007927 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 320373007928 Mg++ binding site [ion binding]; other site 320373007929 putative catalytic motif [active] 320373007930 putative substrate binding site [chemical binding]; other site 320373007931 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320373007932 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 320373007933 putative NAD(P) binding site [chemical binding]; other site 320373007934 active site 320373007935 putative substrate binding site [chemical binding]; other site 320373007936 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 320373007937 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320373007938 active site 320373007939 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320373007940 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 320373007941 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 320373007942 Probable Catalytic site; other site 320373007943 metal-binding site 320373007944 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 320373007945 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 320373007946 active site 320373007947 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373007948 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320373007949 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 320373007950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 320373007951 active site 320373007952 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 320373007953 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 320373007954 Probable Catalytic site; other site 320373007955 metal-binding site 320373007956 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320373007957 extended (e) SDRs; Region: SDR_e; cd08946 320373007958 NAD(P) binding site [chemical binding]; other site 320373007959 active site 320373007960 substrate binding site [chemical binding]; other site 320373007961 Acyltransferase family; Region: Acyl_transf_3; pfam01757 320373007962 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 320373007963 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 320373007964 Walker A/P-loop; other site 320373007965 ATP binding site [chemical binding]; other site 320373007966 Q-loop/lid; other site 320373007967 ABC transporter signature motif; other site 320373007968 Walker B; other site 320373007969 D-loop; other site 320373007970 H-loop/switch region; other site 320373007971 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 320373007972 putative carbohydrate binding site [chemical binding]; other site 320373007973 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 320373007974 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 320373007975 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 320373007976 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 320373007977 NADP binding site [chemical binding]; other site 320373007978 active site 320373007979 putative substrate binding site [chemical binding]; other site 320373007980 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 320373007981 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 320373007982 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 320373007983 substrate binding site; other site 320373007984 tetramer interface; other site 320373007985 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 320373007986 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 320373007987 NAD binding site [chemical binding]; other site 320373007988 substrate binding site [chemical binding]; other site 320373007989 homodimer interface [polypeptide binding]; other site 320373007990 active site 320373007991 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 320373007992 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 320373007993 active site 320373007994 metal binding site [ion binding]; metal-binding site 320373007995 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 320373007996 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 320373007997 putative acyl-acceptor binding pocket; other site 320373007998 dihydroorotase; Provisional; Region: PRK07627 320373007999 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320373008000 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 320373008001 active site 320373008002 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 320373008003 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 320373008004 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 320373008005 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373008006 active site 320373008007 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 320373008008 hypothetical protein; Validated; Region: PRK00228 320373008009 Rubredoxin [Energy production and conversion]; Region: COG1773 320373008010 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 320373008011 iron binding site [ion binding]; other site 320373008012 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 320373008013 dimer interface [polypeptide binding]; other site 320373008014 substrate binding site [chemical binding]; other site 320373008015 ATP binding site [chemical binding]; other site 320373008016 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 320373008017 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 320373008018 ring oligomerisation interface [polypeptide binding]; other site 320373008019 ATP/Mg binding site [chemical binding]; other site 320373008020 stacking interactions; other site 320373008021 hinge regions; other site 320373008022 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 320373008023 oligomerisation interface [polypeptide binding]; other site 320373008024 mobile loop; other site 320373008025 roof hairpin; other site 320373008026 Predicted transcriptional regulators [Transcription]; Region: COG1733 320373008027 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 320373008028 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 320373008029 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 320373008030 putative NAD(P) binding site [chemical binding]; other site 320373008031 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320373008032 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320373008033 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320373008034 Predicted transcriptional regulators [Transcription]; Region: COG1733 320373008035 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373008036 dimerization interface [polypeptide binding]; other site 320373008037 putative DNA binding site [nucleotide binding]; other site 320373008038 putative Zn2+ binding site [ion binding]; other site 320373008039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320373008040 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320373008041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373008042 non-specific DNA binding site [nucleotide binding]; other site 320373008043 salt bridge; other site 320373008044 sequence-specific DNA binding site [nucleotide binding]; other site 320373008045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373008046 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373008047 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 320373008048 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 320373008049 putative active site [active] 320373008050 catalytic site [active] 320373008051 putative metal binding site [ion binding]; other site 320373008052 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320373008053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373008054 putative substrate translocation pore; other site 320373008055 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 320373008056 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 320373008057 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 320373008058 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 320373008059 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 320373008060 BON domain; Region: BON; pfam04972 320373008061 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 320373008062 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 320373008063 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 320373008064 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 320373008065 putative catalytic residue [active] 320373008066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373008067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373008068 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373008069 dimerization interface [polypeptide binding]; other site 320373008070 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 320373008071 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 320373008072 dimer interface [polypeptide binding]; other site 320373008073 putative PBP binding regions; other site 320373008074 ABC-ATPase subunit interface; other site 320373008075 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 320373008076 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 320373008077 putative ligand binding residues [chemical binding]; other site 320373008078 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 320373008079 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 320373008080 Walker A/P-loop; other site 320373008081 ATP binding site [chemical binding]; other site 320373008082 Q-loop/lid; other site 320373008083 ABC transporter signature motif; other site 320373008084 Walker B; other site 320373008085 D-loop; other site 320373008086 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 320373008087 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373008088 N-terminal plug; other site 320373008089 ligand-binding site [chemical binding]; other site 320373008090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 320373008091 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 320373008092 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320373008093 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 320373008094 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 320373008095 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 320373008096 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 320373008097 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373008098 catalytic loop [active] 320373008099 iron binding site [ion binding]; other site 320373008100 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 320373008101 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 320373008102 major facilitator superfamily transporter; Provisional; Region: PRK05122 320373008103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373008104 putative substrate translocation pore; other site 320373008105 EamA-like transporter family; Region: EamA; pfam00892 320373008106 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 320373008107 EamA-like transporter family; Region: EamA; pfam00892 320373008108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373008109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373008110 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 320373008111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373008112 catalytic residue [active] 320373008113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373008114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373008115 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373008116 putative effector binding pocket; other site 320373008117 dimerization interface [polypeptide binding]; other site 320373008118 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 320373008119 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 320373008120 putative ligand binding site [chemical binding]; other site 320373008121 putative NAD binding site [chemical binding]; other site 320373008122 catalytic site [active] 320373008123 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 320373008124 putative FMN binding site [chemical binding]; other site 320373008125 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320373008126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373008127 putative substrate translocation pore; other site 320373008128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373008129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373008130 putative substrate translocation pore; other site 320373008131 fumarylacetoacetase; Region: PLN02856 320373008132 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 320373008133 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 320373008134 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 320373008135 benzoate transport; Region: 2A0115; TIGR00895 320373008136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373008137 putative substrate translocation pore; other site 320373008138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373008139 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 320373008140 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 320373008141 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320373008142 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320373008143 EAL domain; Region: EAL; pfam00563 320373008144 Uncharacterized conserved protein [Function unknown]; Region: COG3791 320373008145 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373008146 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320373008147 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373008148 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 320373008149 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373008150 FAD binding site [chemical binding]; other site 320373008151 substrate binding pocket [chemical binding]; other site 320373008152 catalytic base [active] 320373008153 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 320373008154 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 320373008155 dimer interface [polypeptide binding]; other site 320373008156 decamer (pentamer of dimers) interface [polypeptide binding]; other site 320373008157 catalytic triad [active] 320373008158 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 320373008159 Predicted membrane protein [Function unknown]; Region: COG5393 320373008160 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 320373008161 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 320373008162 Type II transport protein GspH; Region: GspH; pfam12019 320373008163 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 320373008164 ATP cone domain; Region: ATP-cone; pfam03477 320373008165 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 320373008166 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 320373008167 dimer interface [polypeptide binding]; other site 320373008168 active site 320373008169 glycine-pyridoxal phosphate binding site [chemical binding]; other site 320373008170 folate binding site [chemical binding]; other site 320373008171 malonic semialdehyde reductase; Provisional; Region: PRK10538 320373008172 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 320373008173 putative NAD(P) binding site [chemical binding]; other site 320373008174 homodimer interface [polypeptide binding]; other site 320373008175 homotetramer interface [polypeptide binding]; other site 320373008176 active site 320373008177 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 320373008178 active site 320373008179 TolQ protein; Region: tolQ; TIGR02796 320373008180 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 320373008181 TolR protein; Region: tolR; TIGR02801 320373008182 TolA protein; Region: tolA_full; TIGR02794 320373008183 TonB C terminal; Region: TonB_2; pfam13103 320373008184 translocation protein TolB; Provisional; Region: tolB; PRK02889 320373008185 TolB amino-terminal domain; Region: TolB_N; pfam04052 320373008186 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 320373008187 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 320373008188 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 320373008189 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 320373008190 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373008191 ligand binding site [chemical binding]; other site 320373008192 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 320373008193 Tetratricopeptide repeat; Region: TPR_6; pfam13174 320373008194 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 320373008195 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 320373008196 active site 320373008197 tetramer interface; other site 320373008198 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 320373008199 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 320373008200 putative active site [active] 320373008201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 320373008202 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 320373008203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373008204 active site 320373008205 motif I; other site 320373008206 motif II; other site 320373008207 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 320373008208 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 320373008209 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373008210 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373008211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373008212 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373008213 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 320373008214 trimer interface [polypeptide binding]; other site 320373008215 active site 320373008216 substrate binding site [chemical binding]; other site 320373008217 CoA binding site [chemical binding]; other site 320373008218 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 320373008219 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 320373008220 tyrosine kinase; Provisional; Region: PRK11519 320373008221 Chain length determinant protein; Region: Wzz; pfam02706 320373008222 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 320373008223 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 320373008224 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 320373008225 Low molecular weight phosphatase family; Region: LMWPc; cd00115 320373008226 active site 320373008227 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 320373008228 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 320373008229 CoA-binding domain; Region: CoA_binding_3; pfam13727 320373008230 Bacterial sugar transferase; Region: Bac_transf; pfam02397 320373008231 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320373008232 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 320373008233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373008234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373008235 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 320373008236 active site 320373008237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373008238 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 320373008239 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373008240 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373008241 catalytic residue [active] 320373008242 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 320373008243 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 320373008244 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 320373008245 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373008246 active site 320373008247 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 320373008248 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320373008249 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373008250 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320373008251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373008252 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 320373008253 Enoylreductase; Region: PKS_ER; smart00829 320373008254 NAD(P) binding site [chemical binding]; other site 320373008255 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 320373008256 KR domain; Region: KR; pfam08659 320373008257 putative NADP binding site [chemical binding]; other site 320373008258 active site 320373008259 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373008260 Sulfatase; Region: Sulfatase; pfam00884 320373008261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373008262 NAD(P) binding site [chemical binding]; other site 320373008263 active site 320373008264 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 320373008265 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 320373008266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373008267 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 320373008268 active site 320373008269 motif I; other site 320373008270 motif II; other site 320373008271 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 320373008272 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 320373008273 Substrate binding site; other site 320373008274 Mg++ binding site; other site 320373008275 metal-binding site 320373008276 Mg++ binding site; other site 320373008277 metal-binding site 320373008278 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320373008279 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 320373008280 dimer interface [polypeptide binding]; other site 320373008281 active site 320373008282 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 320373008283 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 320373008284 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 320373008285 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 320373008286 NADP-binding site; other site 320373008287 homotetramer interface [polypeptide binding]; other site 320373008288 substrate binding site [chemical binding]; other site 320373008289 homodimer interface [polypeptide binding]; other site 320373008290 active site 320373008291 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 320373008292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373008293 NAD(P) binding site [chemical binding]; other site 320373008294 active site 320373008295 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373008296 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373008297 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 320373008298 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 320373008299 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 320373008300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373008301 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 320373008302 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 320373008303 Walker A/P-loop; other site 320373008304 ATP binding site [chemical binding]; other site 320373008305 Q-loop/lid; other site 320373008306 ABC transporter signature motif; other site 320373008307 Walker B; other site 320373008308 D-loop; other site 320373008309 H-loop/switch region; other site 320373008310 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 320373008311 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 320373008312 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 320373008313 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 320373008314 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 320373008315 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 320373008316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373008317 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 320373008318 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 320373008319 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 320373008320 Substrate binding site; other site 320373008321 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 320373008322 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 320373008323 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 320373008324 putative active site [active] 320373008325 putative dimer interface [polypeptide binding]; other site 320373008326 mechanosensitive channel MscS; Provisional; Region: PRK10334 320373008327 Mechanosensitive ion channel; Region: MS_channel; pfam00924 320373008328 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 320373008329 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 320373008330 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 320373008331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373008332 ATP binding site [chemical binding]; other site 320373008333 Mg2+ binding site [ion binding]; other site 320373008334 G-X-G motif; other site 320373008335 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 320373008336 ATP binding site [chemical binding]; other site 320373008337 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 320373008338 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 320373008339 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 320373008340 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 320373008341 SnoaL-like domain; Region: SnoaL_3; pfam13474 320373008342 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 320373008343 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 320373008344 dimerization interface [polypeptide binding]; other site 320373008345 putative ATP binding site [chemical binding]; other site 320373008346 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 320373008347 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 320373008348 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 320373008349 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 320373008350 poly(A) polymerase; Region: pcnB; TIGR01942 320373008351 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 320373008352 active site 320373008353 NTP binding site [chemical binding]; other site 320373008354 metal binding triad [ion binding]; metal-binding site 320373008355 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 320373008356 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 320373008357 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 320373008358 catalytic center binding site [active] 320373008359 ATP binding site [chemical binding]; other site 320373008360 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 320373008361 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 320373008362 Substrate-binding site [chemical binding]; other site 320373008363 Substrate specificity [chemical binding]; other site 320373008364 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 320373008365 oligomerization interface [polypeptide binding]; other site 320373008366 active site 320373008367 metal binding site [ion binding]; metal-binding site 320373008368 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 320373008369 chorismate binding enzyme; Region: Chorismate_bind; cl10555 320373008370 hypothetical protein; Provisional; Region: PRK07546 320373008371 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 320373008372 homodimer interface [polypeptide binding]; other site 320373008373 substrate-cofactor binding pocket; other site 320373008374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373008375 catalytic residue [active] 320373008376 chaperone protein DnaJ; Provisional; Region: PRK10767 320373008377 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 320373008378 HSP70 interaction site [polypeptide binding]; other site 320373008379 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 320373008380 Zn binding sites [ion binding]; other site 320373008381 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 320373008382 dimer interface [polypeptide binding]; other site 320373008383 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 320373008384 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 320373008385 nucleotide binding site [chemical binding]; other site 320373008386 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320373008387 GrpE; Region: GrpE; pfam01025 320373008388 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 320373008389 dimer interface [polypeptide binding]; other site 320373008390 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 320373008391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320373008392 RNA binding surface [nucleotide binding]; other site 320373008393 ferrochelatase; Reviewed; Region: hemH; PRK00035 320373008394 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 320373008395 C-terminal domain interface [polypeptide binding]; other site 320373008396 active site 320373008397 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 320373008398 active site 320373008399 N-terminal domain interface [polypeptide binding]; other site 320373008400 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 320373008401 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 320373008402 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 320373008403 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 320373008404 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 320373008405 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 320373008406 Walker A/P-loop; other site 320373008407 ATP binding site [chemical binding]; other site 320373008408 Q-loop/lid; other site 320373008409 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 320373008410 ABC transporter signature motif; other site 320373008411 Walker B; other site 320373008412 D-loop; other site 320373008413 H-loop/switch region; other site 320373008414 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 320373008415 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 320373008416 metal binding triad; other site 320373008417 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 320373008418 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 320373008419 metal binding triad; other site 320373008420 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 320373008421 TIGR02099 family protein; Region: TIGR02099 320373008422 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 320373008423 nitrilase; Region: PLN02798 320373008424 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 320373008425 putative active site [active] 320373008426 catalytic triad [active] 320373008427 dimer interface [polypeptide binding]; other site 320373008428 protease TldD; Provisional; Region: tldD; PRK10735 320373008429 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 320373008430 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 320373008431 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 320373008432 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 320373008433 heme-binding site [chemical binding]; other site 320373008434 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 320373008435 FAD binding pocket [chemical binding]; other site 320373008436 FAD binding motif [chemical binding]; other site 320373008437 phosphate binding motif [ion binding]; other site 320373008438 beta-alpha-beta structure motif; other site 320373008439 NAD binding pocket [chemical binding]; other site 320373008440 Heme binding pocket [chemical binding]; other site 320373008441 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 320373008442 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320373008443 FAD binding domain; Region: FAD_binding_4; pfam01565 320373008444 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 320373008445 FAD binding domain; Region: FAD_binding_4; pfam01565 320373008446 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 320373008447 FAD binding domain; Region: FAD_binding_4; pfam01565 320373008448 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 320373008449 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 320373008450 Cysteine-rich domain; Region: CCG; pfam02754 320373008451 Cysteine-rich domain; Region: CCG; pfam02754 320373008452 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 320373008453 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320373008454 catalytic residue [active] 320373008455 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 320373008456 pyrroline-5-carboxylate reductase; Region: PLN02688 320373008457 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 320373008458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373008459 dimer interface [polypeptide binding]; other site 320373008460 conserved gate region; other site 320373008461 ABC-ATPase subunit interface; other site 320373008462 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 320373008463 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 320373008464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373008465 Walker A/P-loop; other site 320373008466 ATP binding site [chemical binding]; other site 320373008467 Q-loop/lid; other site 320373008468 ABC transporter signature motif; other site 320373008469 Walker B; other site 320373008470 D-loop; other site 320373008471 H-loop/switch region; other site 320373008472 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 320373008473 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320373008474 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 320373008475 active site 320373008476 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 320373008477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373008478 Walker A/P-loop; other site 320373008479 ATP binding site [chemical binding]; other site 320373008480 Q-loop/lid; other site 320373008481 ABC transporter signature motif; other site 320373008482 Walker B; other site 320373008483 D-loop; other site 320373008484 H-loop/switch region; other site 320373008485 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 320373008486 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373008487 Walker A/P-loop; other site 320373008488 ATP binding site [chemical binding]; other site 320373008489 Q-loop/lid; other site 320373008490 ABC transporter signature motif; other site 320373008491 Walker B; other site 320373008492 D-loop; other site 320373008493 H-loop/switch region; other site 320373008494 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320373008495 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 320373008496 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 320373008497 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 320373008498 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 320373008499 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 320373008500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373008501 DNA-binding site [nucleotide binding]; DNA binding site 320373008502 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 320373008503 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 320373008504 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 320373008505 active site 320373008506 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 320373008507 UbiA prenyltransferase family; Region: UbiA; pfam01040 320373008508 Predicted transcriptional regulators [Transcription]; Region: COG1733 320373008509 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 320373008510 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 320373008511 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 320373008512 dimerization interface [polypeptide binding]; other site 320373008513 DPS ferroxidase diiron center [ion binding]; other site 320373008514 ion pore; other site 320373008515 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 320373008516 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 320373008517 dimer interface [polypeptide binding]; other site 320373008518 active site 320373008519 heme binding site [chemical binding]; other site 320373008520 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 320373008521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373008522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373008523 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 320373008524 dimerization interface [polypeptide binding]; other site 320373008525 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 320373008526 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 320373008527 generic binding surface II; other site 320373008528 ssDNA binding site; other site 320373008529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320373008530 ATP binding site [chemical binding]; other site 320373008531 putative Mg++ binding site [ion binding]; other site 320373008532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373008533 nucleotide binding region [chemical binding]; other site 320373008534 ATP-binding site [chemical binding]; other site 320373008535 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 320373008536 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 320373008537 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 320373008538 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 320373008539 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 320373008540 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 320373008541 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 320373008542 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 320373008543 Protein export membrane protein; Region: SecD_SecF; cl14618 320373008544 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 320373008545 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 320373008546 Protein export membrane protein; Region: SecD_SecF; pfam02355 320373008547 citrate-proton symporter; Provisional; Region: PRK15075 320373008548 Uncharacterized conserved protein [Function unknown]; Region: COG2353 320373008549 YceI-like domain; Region: YceI; smart00867 320373008550 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 320373008551 Paraquat-inducible protein A; Region: PqiA; pfam04403 320373008552 Paraquat-inducible protein A; Region: PqiA; pfam04403 320373008553 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 320373008554 mce related protein; Region: MCE; pfam02470 320373008555 mce related protein; Region: MCE; pfam02470 320373008556 Protein of unknown function (DUF330); Region: DUF330; pfam03886 320373008557 Site-specific recombinase; Region: SpecificRecomb; pfam10136 320373008558 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 320373008559 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 320373008560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 320373008561 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 320373008562 Predicted transcriptional regulator [Transcription]; Region: COG2378 320373008563 HTH domain; Region: HTH_11; pfam08279 320373008564 WYL domain; Region: WYL; pfam13280 320373008565 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 320373008566 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 320373008567 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 320373008568 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 320373008569 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 320373008570 ligand binding site [chemical binding]; other site 320373008571 homodimer interface [polypeptide binding]; other site 320373008572 NAD(P) binding site [chemical binding]; other site 320373008573 trimer interface B [polypeptide binding]; other site 320373008574 trimer interface A [polypeptide binding]; other site 320373008575 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 320373008576 nudix motif; other site 320373008577 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 320373008578 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 320373008579 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 320373008580 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 320373008581 active site 320373008582 FMN binding site [chemical binding]; other site 320373008583 substrate binding site [chemical binding]; other site 320373008584 3Fe-4S cluster binding site [ion binding]; other site 320373008585 putative glutathione S-transferase; Provisional; Region: PRK10357 320373008586 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 320373008587 putative C-terminal domain interface [polypeptide binding]; other site 320373008588 putative GSH binding site (G-site) [chemical binding]; other site 320373008589 putative dimer interface [polypeptide binding]; other site 320373008590 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 320373008591 dimer interface [polypeptide binding]; other site 320373008592 N-terminal domain interface [polypeptide binding]; other site 320373008593 putative substrate binding pocket (H-site) [chemical binding]; other site 320373008594 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 320373008595 proline aminopeptidase P II; Provisional; Region: PRK10879 320373008596 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 320373008597 active site 320373008598 hypothetical protein; Provisional; Region: PRK06996 320373008599 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320373008600 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 320373008601 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 320373008602 FMN binding site [chemical binding]; other site 320373008603 active site 320373008604 catalytic residues [active] 320373008605 substrate binding site [chemical binding]; other site 320373008606 DNA-binding protein Fis; Provisional; Region: PRK01905 320373008607 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 320373008608 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 320373008609 purine monophosphate binding site [chemical binding]; other site 320373008610 dimer interface [polypeptide binding]; other site 320373008611 putative catalytic residues [active] 320373008612 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 320373008613 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 320373008614 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 320373008615 active site 320373008616 putative DNA-binding cleft [nucleotide binding]; other site 320373008617 dimer interface [polypeptide binding]; other site 320373008618 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 320373008619 RuvA N terminal domain; Region: RuvA_N; pfam01330 320373008620 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 320373008621 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 320373008622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373008623 Walker A motif; other site 320373008624 ATP binding site [chemical binding]; other site 320373008625 Walker B motif; other site 320373008626 arginine finger; other site 320373008627 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 320373008628 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 320373008629 Putative ParB-like nuclease; Region: ParBc_2; cl17538 320373008630 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320373008631 catalytic core [active] 320373008632 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 320373008633 putative active site [active] 320373008634 dimerization interface [polypeptide binding]; other site 320373008635 putative tRNAtyr binding site [nucleotide binding]; other site 320373008636 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 320373008637 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 320373008638 active site 320373008639 HIGH motif; other site 320373008640 dimer interface [polypeptide binding]; other site 320373008641 KMSKS motif; other site 320373008642 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320373008643 RNA binding surface [nucleotide binding]; other site 320373008644 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 320373008645 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 320373008646 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 320373008647 C-terminal domain interface [polypeptide binding]; other site 320373008648 GSH binding site (G-site) [chemical binding]; other site 320373008649 dimer interface [polypeptide binding]; other site 320373008650 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 320373008651 N-terminal domain interface [polypeptide binding]; other site 320373008652 putative dimer interface [polypeptide binding]; other site 320373008653 active site 320373008654 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 320373008655 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 320373008656 C-terminal domain interface [polypeptide binding]; other site 320373008657 GSH binding site (G-site) [chemical binding]; other site 320373008658 dimer interface [polypeptide binding]; other site 320373008659 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 320373008660 N-terminal domain interface [polypeptide binding]; other site 320373008661 dimer interface [polypeptide binding]; other site 320373008662 substrate binding pocket (H-site) [chemical binding]; other site 320373008663 Cupin; Region: Cupin_6; pfam12852 320373008664 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373008665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373008666 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 320373008667 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 320373008668 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 320373008669 23S rRNA interface [nucleotide binding]; other site 320373008670 L3 interface [polypeptide binding]; other site 320373008671 OsmC-like protein; Region: OsmC; cl00767 320373008672 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 320373008673 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 320373008674 active site 320373008675 substrate binding pocket [chemical binding]; other site 320373008676 dimer interface [polypeptide binding]; other site 320373008677 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 320373008678 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 320373008679 putative active site [active] 320373008680 putative dimer interface [polypeptide binding]; other site 320373008681 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320373008682 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 320373008683 putative dimer interface [polypeptide binding]; other site 320373008684 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320373008685 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 320373008686 putative dimer interface [polypeptide binding]; other site 320373008687 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 320373008688 oligomerisation interface [polypeptide binding]; other site 320373008689 mobile loop; other site 320373008690 roof hairpin; other site 320373008691 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 320373008692 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320373008693 Walker A/P-loop; other site 320373008694 ATP binding site [chemical binding]; other site 320373008695 Q-loop/lid; other site 320373008696 ABC transporter signature motif; other site 320373008697 Walker B; other site 320373008698 D-loop; other site 320373008699 H-loop/switch region; other site 320373008700 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320373008701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373008702 dimer interface [polypeptide binding]; other site 320373008703 conserved gate region; other site 320373008704 putative PBP binding loops; other site 320373008705 ABC-ATPase subunit interface; other site 320373008706 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320373008707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373008708 dimer interface [polypeptide binding]; other site 320373008709 conserved gate region; other site 320373008710 putative PBP binding loops; other site 320373008711 ABC-ATPase subunit interface; other site 320373008712 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 320373008713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373008714 substrate binding pocket [chemical binding]; other site 320373008715 membrane-bound complex binding site; other site 320373008716 hinge residues; other site 320373008717 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 320373008718 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 320373008719 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 320373008720 NAD(P) binding site [chemical binding]; other site 320373008721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373008722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373008723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373008724 dimerization interface [polypeptide binding]; other site 320373008725 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 320373008726 adenylosuccinate lyase; Provisional; Region: PRK09285 320373008727 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 320373008728 tetramer interface [polypeptide binding]; other site 320373008729 active site 320373008730 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 320373008731 ATP-binding site [chemical binding]; other site 320373008732 Gluconate-6-phosphate binding site [chemical binding]; other site 320373008733 Shikimate kinase; Region: SKI; pfam01202 320373008734 GntP family permease; Region: GntP_permease; pfam02447 320373008735 fructuronate transporter; Provisional; Region: PRK10034; cl15264 320373008736 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 320373008737 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 320373008738 active site 320373008739 intersubunit interface [polypeptide binding]; other site 320373008740 catalytic residue [active] 320373008741 phosphogluconate dehydratase; Validated; Region: PRK09054 320373008742 6-phosphogluconate dehydratase; Region: edd; TIGR01196 320373008743 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320373008744 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320373008745 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320373008746 putative active site [active] 320373008747 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 320373008748 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 320373008749 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 320373008750 putative catalytic cysteine [active] 320373008751 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 320373008752 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 320373008753 Lipopolysaccharide-assembly; Region: LptE; cl01125 320373008754 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 320373008755 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 320373008756 HIGH motif; other site 320373008757 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 320373008758 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320373008759 active site 320373008760 KMSKS motif; other site 320373008761 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 320373008762 tRNA binding surface [nucleotide binding]; other site 320373008763 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 320373008764 TolR protein; Region: tolR; TIGR02801 320373008765 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 320373008766 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 320373008767 dihydrodipicolinate reductase; Provisional; Region: PRK00048 320373008768 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 320373008769 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 320373008770 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 320373008771 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 320373008772 ferric uptake regulator; Provisional; Region: fur; PRK09462 320373008773 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 320373008774 metal binding site 2 [ion binding]; metal-binding site 320373008775 putative DNA binding helix; other site 320373008776 metal binding site 1 [ion binding]; metal-binding site 320373008777 dimer interface [polypeptide binding]; other site 320373008778 structural Zn2+ binding site [ion binding]; other site 320373008779 ureidoglycolate hydrolase; Provisional; Region: PRK13395 320373008780 allantoicase; Provisional; Region: PRK13257 320373008781 Allantoicase repeat; Region: Allantoicase; pfam03561 320373008782 Allantoicase repeat; Region: Allantoicase; pfam03561 320373008783 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 320373008784 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 320373008785 Transcriptional regulators [Transcription]; Region: FadR; COG2186 320373008786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373008787 DNA-binding site [nucleotide binding]; DNA binding site 320373008788 FCD domain; Region: FCD; pfam07729 320373008789 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 320373008790 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373008791 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 320373008792 dimerization interface [polypeptide binding]; other site 320373008793 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 320373008794 active site clefts [active] 320373008795 zinc binding site [ion binding]; other site 320373008796 dimer interface [polypeptide binding]; other site 320373008797 cyanate hydratase; Validated; Region: PRK02866 320373008798 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 320373008799 oligomer interface [polypeptide binding]; other site 320373008800 active site 320373008801 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320373008802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373008803 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 320373008804 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 320373008805 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 320373008806 transketolase; Reviewed; Region: PRK12753 320373008807 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 320373008808 TPP-binding site [chemical binding]; other site 320373008809 dimer interface [polypeptide binding]; other site 320373008810 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 320373008811 PYR/PP interface [polypeptide binding]; other site 320373008812 dimer interface [polypeptide binding]; other site 320373008813 TPP binding site [chemical binding]; other site 320373008814 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 320373008815 spermidine synthase; Provisional; Region: PRK00811 320373008816 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 320373008817 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 320373008818 putative dimer interface [polypeptide binding]; other site 320373008819 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373008820 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 320373008821 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 320373008822 putative RNAase interaction site [polypeptide binding]; other site 320373008823 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 320373008824 active site 320373008825 barstar interaction site; other site 320373008826 malic enzyme; Reviewed; Region: PRK12862 320373008827 Malic enzyme, N-terminal domain; Region: malic; pfam00390 320373008828 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 320373008829 putative NAD(P) binding site [chemical binding]; other site 320373008830 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 320373008831 thiamine monophosphate kinase; Provisional; Region: PRK05731 320373008832 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 320373008833 ATP binding site [chemical binding]; other site 320373008834 dimerization interface [polypeptide binding]; other site 320373008835 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 320373008836 tetramer interfaces [polypeptide binding]; other site 320373008837 binuclear metal-binding site [ion binding]; other site 320373008838 Competence-damaged protein; Region: CinA; pfam02464 320373008839 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 320373008840 active site 320373008841 dimer interface [polypeptide binding]; other site 320373008842 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 320373008843 active site 320373008844 catalytic residues [active] 320373008845 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320373008846 classical (c) SDRs; Region: SDR_c; cd05233 320373008847 NAD(P) binding site [chemical binding]; other site 320373008848 active site 320373008849 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373008850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373008851 TM-ABC transporter signature motif; other site 320373008852 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 320373008853 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320373008854 Walker A/P-loop; other site 320373008855 ATP binding site [chemical binding]; other site 320373008856 Q-loop/lid; other site 320373008857 ABC transporter signature motif; other site 320373008858 Walker B; other site 320373008859 D-loop; other site 320373008860 H-loop/switch region; other site 320373008861 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320373008862 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 320373008863 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 320373008864 ligand binding site [chemical binding]; other site 320373008865 short chain dehydrogenase; Provisional; Region: PRK07063 320373008866 classical (c) SDRs; Region: SDR_c; cd05233 320373008867 NAD(P) binding site [chemical binding]; other site 320373008868 active site 320373008869 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 320373008870 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 320373008871 active site 320373008872 intersubunit interface [polypeptide binding]; other site 320373008873 catalytic residue [active] 320373008874 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 320373008875 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 320373008876 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373008877 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320373008878 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373008879 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 320373008880 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 320373008881 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 320373008882 Transglycosylase; Region: Transgly; cl17702 320373008883 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 320373008884 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 320373008885 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 320373008886 shikimate binding site; other site 320373008887 NAD(P) binding site [chemical binding]; other site 320373008888 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 320373008889 RNB domain; Region: RNB; pfam00773 320373008890 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 320373008891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320373008892 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 320373008893 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 320373008894 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320373008895 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320373008896 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 320373008897 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320373008898 catalytic residues [active] 320373008899 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 320373008900 Dehydroquinase class II; Region: DHquinase_II; pfam01220 320373008901 active site 320373008902 trimer interface [polypeptide binding]; other site 320373008903 dimer interface [polypeptide binding]; other site 320373008904 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 320373008905 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 320373008906 carboxyltransferase (CT) interaction site; other site 320373008907 biotinylation site [posttranslational modification]; other site 320373008908 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 320373008909 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320373008910 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320373008911 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 320373008912 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 320373008913 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320373008914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373008915 S-adenosylmethionine binding site [chemical binding]; other site 320373008916 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 320373008917 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 320373008918 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 320373008919 dimer interface [polypeptide binding]; other site 320373008920 catalytic triad [active] 320373008921 peroxidatic and resolving cysteines [active] 320373008922 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320373008923 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 320373008924 substrate binding site [chemical binding]; other site 320373008925 ATP binding site [chemical binding]; other site 320373008926 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 320373008927 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 320373008928 dimer interface [polypeptide binding]; other site 320373008929 putative radical transfer pathway; other site 320373008930 diiron center [ion binding]; other site 320373008931 tyrosyl radical; other site 320373008932 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 320373008933 ATP cone domain; Region: ATP-cone; pfam03477 320373008934 Class I ribonucleotide reductase; Region: RNR_I; cd01679 320373008935 active site 320373008936 dimer interface [polypeptide binding]; other site 320373008937 catalytic residues [active] 320373008938 effector binding site; other site 320373008939 R2 peptide binding site; other site 320373008940 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 320373008941 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 320373008942 amidase catalytic site [active] 320373008943 Zn binding residues [ion binding]; other site 320373008944 substrate binding site [chemical binding]; other site 320373008945 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 320373008946 signal recognition particle protein; Provisional; Region: PRK10867 320373008947 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 320373008948 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 320373008949 P loop; other site 320373008950 GTP binding site [chemical binding]; other site 320373008951 Signal peptide binding domain; Region: SRP_SPB; pfam02978 320373008952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373008953 active site 320373008954 MarC family integral membrane protein; Region: MarC; cl00919 320373008955 prolyl-tRNA synthetase; Provisional; Region: PRK09194 320373008956 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 320373008957 dimer interface [polypeptide binding]; other site 320373008958 motif 1; other site 320373008959 active site 320373008960 motif 2; other site 320373008961 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 320373008962 putative deacylase active site [active] 320373008963 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 320373008964 active site 320373008965 motif 3; other site 320373008966 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 320373008967 anticodon binding site; other site 320373008968 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 320373008969 putative active site [active] 320373008970 Ap4A binding site [chemical binding]; other site 320373008971 nudix motif; other site 320373008972 putative metal binding site [ion binding]; other site 320373008973 CNP1-like family; Region: CNP1; pfam08750 320373008974 gamma-glutamyl kinase; Provisional; Region: PRK05429 320373008975 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 320373008976 nucleotide binding site [chemical binding]; other site 320373008977 homotetrameric interface [polypeptide binding]; other site 320373008978 putative phosphate binding site [ion binding]; other site 320373008979 putative allosteric binding site; other site 320373008980 PUA domain; Region: PUA; pfam01472 320373008981 GTPase CgtA; Reviewed; Region: obgE; PRK12298 320373008982 GTP1/OBG; Region: GTP1_OBG; pfam01018 320373008983 Obg GTPase; Region: Obg; cd01898 320373008984 G1 box; other site 320373008985 GTP/Mg2+ binding site [chemical binding]; other site 320373008986 Switch I region; other site 320373008987 G2 box; other site 320373008988 G3 box; other site 320373008989 Switch II region; other site 320373008990 G4 box; other site 320373008991 G5 box; other site 320373008992 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 320373008993 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 320373008994 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 320373008995 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 320373008996 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 320373008997 substrate binding pocket [chemical binding]; other site 320373008998 chain length determination region; other site 320373008999 substrate-Mg2+ binding site; other site 320373009000 catalytic residues [active] 320373009001 aspartate-rich region 1; other site 320373009002 active site lid residues [active] 320373009003 aspartate-rich region 2; other site 320373009004 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373009005 active site 320373009006 DNA binding site [nucleotide binding] 320373009007 Int/Topo IB signature motif; other site 320373009008 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320373009009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373009010 non-specific DNA binding site [nucleotide binding]; other site 320373009011 salt bridge; other site 320373009012 sequence-specific DNA binding site [nucleotide binding]; other site 320373009013 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320373009014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373009015 non-specific DNA binding site [nucleotide binding]; other site 320373009016 salt bridge; other site 320373009017 sequence-specific DNA binding site [nucleotide binding]; other site 320373009018 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 320373009019 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 320373009020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 320373009021 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 320373009022 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 320373009023 cofactor binding site; other site 320373009024 DNA binding site [nucleotide binding] 320373009025 substrate interaction site [chemical binding]; other site 320373009026 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 320373009027 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 320373009028 Domain of unknown function DUF21; Region: DUF21; pfam01595 320373009029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 320373009030 Transporter associated domain; Region: CorC_HlyC; smart01091 320373009031 Type II/IV secretion system protein; Region: T2SE; pfam00437 320373009032 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 320373009033 Walker A motif; other site 320373009034 ATP binding site [chemical binding]; other site 320373009035 Walker B motif; other site 320373009036 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 320373009037 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373009038 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373009039 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 320373009040 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 320373009041 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 320373009042 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 320373009043 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 320373009044 CoA-binding site [chemical binding]; other site 320373009045 ATP-binding [chemical binding]; other site 320373009046 hypothetical protein; Provisional; Region: PRK05287 320373009047 Domain of unknown function (DUF329); Region: DUF329; pfam03884 320373009048 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 320373009049 active site 320373009050 8-oxo-dGMP binding site [chemical binding]; other site 320373009051 nudix motif; other site 320373009052 metal binding site [ion binding]; metal-binding site 320373009053 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 320373009054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373009055 Walker A motif; other site 320373009056 ATP binding site [chemical binding]; other site 320373009057 Walker B motif; other site 320373009058 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 320373009059 heterotetramer interface [polypeptide binding]; other site 320373009060 active site pocket [active] 320373009061 cleavage site 320373009062 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 320373009063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 320373009064 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 320373009065 SEC-C motif; Region: SEC-C; pfam02810 320373009066 Protein of unknown function (DUF721); Region: DUF721; pfam05258 320373009067 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 320373009068 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 320373009069 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 320373009070 catalytic triad [active] 320373009071 dimer interface [polypeptide binding]; other site 320373009072 cell division protein FtsZ; Validated; Region: PRK09330 320373009073 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 320373009074 nucleotide binding site [chemical binding]; other site 320373009075 SulA interaction site; other site 320373009076 cell division protein FtsA; Region: ftsA; TIGR01174 320373009077 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 320373009078 nucleotide binding site [chemical binding]; other site 320373009079 Cell division protein FtsA; Region: FtsA; pfam14450 320373009080 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 320373009081 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 320373009082 Cell division protein FtsQ; Region: FtsQ; pfam03799 320373009083 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 320373009084 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 320373009085 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320373009086 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 320373009087 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 320373009088 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320373009089 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320373009090 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 320373009091 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 320373009092 active site 320373009093 homodimer interface [polypeptide binding]; other site 320373009094 cell division protein FtsW; Region: ftsW; TIGR02614 320373009095 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 320373009096 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320373009097 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320373009098 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 320373009099 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 320373009100 Mg++ binding site [ion binding]; other site 320373009101 putative catalytic motif [active] 320373009102 putative substrate binding site [chemical binding]; other site 320373009103 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 320373009104 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 320373009105 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320373009106 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320373009107 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 320373009108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320373009109 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320373009110 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 320373009111 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320373009112 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320373009113 Cell division protein FtsL; Region: FtsL; pfam04999 320373009114 MraW methylase family; Region: Methyltransf_5; cl17771 320373009115 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 320373009116 cell division protein MraZ; Reviewed; Region: PRK00326 320373009117 MraZ protein; Region: MraZ; pfam02381 320373009118 MraZ protein; Region: MraZ; pfam02381 320373009119 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 320373009120 diiron binding motif [ion binding]; other site 320373009121 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373009122 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373009123 trimer interface [polypeptide binding]; other site 320373009124 eyelet of channel; other site 320373009125 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 320373009126 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 320373009127 acyl-activating enzyme (AAE) consensus motif; other site 320373009128 putative AMP binding site [chemical binding]; other site 320373009129 putative active site [active] 320373009130 putative CoA binding site [chemical binding]; other site 320373009131 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 320373009132 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 320373009133 putative [4Fe-4S] binding site [ion binding]; other site 320373009134 putative molybdopterin cofactor binding site [chemical binding]; other site 320373009135 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 320373009136 putative molybdopterin cofactor binding site; other site 320373009137 enoyl-CoA hydratase; Provisional; Region: PRK05862 320373009138 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373009139 substrate binding site [chemical binding]; other site 320373009140 oxyanion hole (OAH) forming residues; other site 320373009141 trimer interface [polypeptide binding]; other site 320373009142 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 320373009143 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320373009144 NAD(P) binding site [chemical binding]; other site 320373009145 catalytic residues [active] 320373009146 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 320373009147 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320373009148 dimer interface [polypeptide binding]; other site 320373009149 active site 320373009150 enoyl-CoA hydratase; Provisional; Region: PRK08140 320373009151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373009152 substrate binding site [chemical binding]; other site 320373009153 oxyanion hole (OAH) forming residues; other site 320373009154 trimer interface [polypeptide binding]; other site 320373009155 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320373009156 CoenzymeA binding site [chemical binding]; other site 320373009157 subunit interaction site [polypeptide binding]; other site 320373009158 PHB binding site; other site 320373009159 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 320373009160 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 320373009161 active site 320373009162 AMP binding site [chemical binding]; other site 320373009163 homodimer interface [polypeptide binding]; other site 320373009164 acyl-activating enzyme (AAE) consensus motif; other site 320373009165 CoA binding site [chemical binding]; other site 320373009166 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 320373009167 MltA specific insert domain; Region: MltA; smart00925 320373009168 3D domain; Region: 3D; pfam06725 320373009169 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 320373009170 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 320373009171 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 320373009172 substrate binding site [chemical binding]; other site 320373009173 hexamer interface [polypeptide binding]; other site 320373009174 metal binding site [ion binding]; metal-binding site 320373009175 phosphoglycolate phosphatase; Provisional; Region: PRK13222 320373009176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373009177 motif II; other site 320373009178 anthranilate synthase component I; Provisional; Region: PRK13565 320373009179 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 320373009180 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 320373009181 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 320373009182 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 320373009183 glutamine binding [chemical binding]; other site 320373009184 catalytic triad [active] 320373009185 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 320373009186 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 320373009187 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 320373009188 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 320373009189 active site 320373009190 ribulose/triose binding site [chemical binding]; other site 320373009191 phosphate binding site [ion binding]; other site 320373009192 substrate (anthranilate) binding pocket [chemical binding]; other site 320373009193 product (indole) binding pocket [chemical binding]; other site 320373009194 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 320373009195 putative active site [active] 320373009196 putative metal binding residues [ion binding]; other site 320373009197 signature motif; other site 320373009198 putative triphosphate binding site [ion binding]; other site 320373009199 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 320373009200 ligand binding site [chemical binding]; other site 320373009201 active site 320373009202 UGI interface [polypeptide binding]; other site 320373009203 catalytic site [active] 320373009204 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 320373009205 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320373009206 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 320373009207 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 320373009208 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320373009209 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 320373009210 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 320373009211 dimerization domain [polypeptide binding]; other site 320373009212 dimer interface [polypeptide binding]; other site 320373009213 catalytic residues [active] 320373009214 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 320373009215 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 320373009216 GTP-binding protein YchF; Reviewed; Region: PRK09601 320373009217 YchF GTPase; Region: YchF; cd01900 320373009218 G1 box; other site 320373009219 GTP/Mg2+ binding site [chemical binding]; other site 320373009220 Switch I region; other site 320373009221 G2 box; other site 320373009222 Switch II region; other site 320373009223 G3 box; other site 320373009224 G4 box; other site 320373009225 G5 box; other site 320373009226 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 320373009227 NADH dehydrogenase subunit B; Validated; Region: PRK06411 320373009228 Helix-turn-helix domain; Region: HTH_18; pfam12833 320373009229 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 320373009230 Protein of unknown function (DUF419); Region: DUF419; cl15265 320373009231 Protein of unknown function (DUF419); Region: DUF419; cl15265 320373009232 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 320373009233 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 320373009234 active site 320373009235 catalytic site [active] 320373009236 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 320373009237 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 320373009238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373009239 Walker A/P-loop; other site 320373009240 ATP binding site [chemical binding]; other site 320373009241 Q-loop/lid; other site 320373009242 ABC transporter signature motif; other site 320373009243 Walker B; other site 320373009244 D-loop; other site 320373009245 H-loop/switch region; other site 320373009246 ABC transporter; Region: ABC_tran_2; pfam12848 320373009247 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 320373009248 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 320373009249 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 320373009250 Isochorismatase family; Region: Isochorismatase; pfam00857 320373009251 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 320373009252 catalytic triad [active] 320373009253 conserved cis-peptide bond; other site 320373009254 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 320373009255 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 320373009256 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 320373009257 active site 320373009258 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 320373009259 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 320373009260 tRNA; other site 320373009261 putative tRNA binding site [nucleotide binding]; other site 320373009262 putative NADP binding site [chemical binding]; other site 320373009263 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 320373009264 peptide chain release factor 1; Validated; Region: prfA; PRK00591 320373009265 This domain is found in peptide chain release factors; Region: PCRF; smart00937 320373009266 RF-1 domain; Region: RF-1; pfam00472 320373009267 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 320373009268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373009269 S-adenosylmethionine binding site [chemical binding]; other site 320373009270 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 320373009271 putative GSH binding site [chemical binding]; other site 320373009272 catalytic residues [active] 320373009273 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 320373009274 Flavoprotein; Region: Flavoprotein; pfam02441 320373009275 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 320373009276 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 320373009277 putative active site [active] 320373009278 metal binding site [ion binding]; metal-binding site 320373009279 amino acid transporter; Region: 2A0306; TIGR00909 320373009280 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 320373009281 DNA-binding site [nucleotide binding]; DNA binding site 320373009282 RNA-binding motif; other site 320373009283 putative chaperone; Provisional; Region: PRK11678 320373009284 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 320373009285 nucleotide binding site [chemical binding]; other site 320373009286 putative NEF/HSP70 interaction site [polypeptide binding]; other site 320373009287 SBD interface [polypeptide binding]; other site 320373009288 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 320373009289 putative FMN binding site [chemical binding]; other site 320373009290 D-galactonate transporter; Region: 2A0114; TIGR00893 320373009291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373009292 putative substrate translocation pore; other site 320373009293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373009294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373009295 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 320373009296 Methyltransferase domain; Region: Methyltransf_32; pfam13679 320373009297 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373009298 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 320373009299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373009300 S-adenosylmethionine binding site [chemical binding]; other site 320373009301 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320373009302 Water Stress and Hypersensitive response; Region: WHy; smart00769 320373009303 Peptidase family M1; Region: Peptidase_M1; pfam01433 320373009304 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 320373009305 Zn binding site [ion binding]; other site 320373009306 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 320373009307 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373009308 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373009309 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 320373009310 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 320373009311 putative active site [active] 320373009312 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320373009313 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 320373009314 Walker A/P-loop; other site 320373009315 ATP binding site [chemical binding]; other site 320373009316 Q-loop/lid; other site 320373009317 ABC transporter signature motif; other site 320373009318 Walker B; other site 320373009319 D-loop; other site 320373009320 H-loop/switch region; other site 320373009321 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 320373009322 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 320373009323 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 320373009324 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 320373009325 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320373009326 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320373009327 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320373009328 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 320373009329 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 320373009330 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373009331 ligand binding site [chemical binding]; other site 320373009332 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 320373009333 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320373009334 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 320373009335 Clp amino terminal domain; Region: Clp_N; pfam02861 320373009336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373009337 Walker A motif; other site 320373009338 ATP binding site [chemical binding]; other site 320373009339 Walker B motif; other site 320373009340 arginine finger; other site 320373009341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373009342 Walker A motif; other site 320373009343 ATP binding site [chemical binding]; other site 320373009344 Walker B motif; other site 320373009345 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320373009346 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 320373009347 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320373009348 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 320373009349 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 320373009350 Protein of unknown function (DUF796); Region: DUF796; pfam05638 320373009351 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 320373009352 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320373009353 Protein of unknown function (DUF770); Region: DUF770; pfam05591 320373009354 TPR repeat; Region: TPR_11; pfam13414 320373009355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373009356 TPR motif; other site 320373009357 binding surface 320373009358 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 320373009359 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 320373009360 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320373009361 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 320373009362 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373009363 Transposase; Region: HTH_Tnp_1; pfam01527 320373009364 HTH-like domain; Region: HTH_21; pfam13276 320373009365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320373009366 Integrase core domain; Region: rve; pfam00665 320373009367 Integrase core domain; Region: rve_3; pfam13683 320373009368 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 320373009369 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 320373009370 Methyltransferase domain; Region: Methyltransf_26; pfam13659 320373009371 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 320373009372 stringent starvation protein A; Provisional; Region: sspA; PRK09481 320373009373 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 320373009374 C-terminal domain interface [polypeptide binding]; other site 320373009375 putative GSH binding site (G-site) [chemical binding]; other site 320373009376 dimer interface [polypeptide binding]; other site 320373009377 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 320373009378 dimer interface [polypeptide binding]; other site 320373009379 N-terminal domain interface [polypeptide binding]; other site 320373009380 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 320373009381 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 320373009382 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 320373009383 Qi binding site; other site 320373009384 intrachain domain interface; other site 320373009385 interchain domain interface [polypeptide binding]; other site 320373009386 heme bH binding site [chemical binding]; other site 320373009387 heme bL binding site [chemical binding]; other site 320373009388 Qo binding site; other site 320373009389 interchain domain interface [polypeptide binding]; other site 320373009390 intrachain domain interface; other site 320373009391 Qi binding site; other site 320373009392 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 320373009393 Qo binding site; other site 320373009394 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 320373009395 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 320373009396 [2Fe-2S] cluster binding site [ion binding]; other site 320373009397 Uncharacterized conserved protein [Function unknown]; Region: COG0327 320373009398 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 320373009399 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 320373009400 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 320373009401 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 320373009402 protein binding site [polypeptide binding]; other site 320373009403 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 320373009404 sec-independent translocase; Provisional; Region: tatB; PRK01919 320373009405 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 320373009406 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 320373009407 nucleotide binding site/active site [active] 320373009408 HIT family signature motif; other site 320373009409 catalytic residue [active] 320373009410 Predicted membrane protein [Function unknown]; Region: COG3671 320373009411 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 320373009412 metal binding site [ion binding]; metal-binding site 320373009413 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 320373009414 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 320373009415 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 320373009416 substrate binding site [chemical binding]; other site 320373009417 glutamase interaction surface [polypeptide binding]; other site 320373009418 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 320373009419 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 320373009420 catalytic residues [active] 320373009421 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 320373009422 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 320373009423 putative active site [active] 320373009424 oxyanion strand; other site 320373009425 catalytic triad [active] 320373009426 MarC family integral membrane protein; Region: MarC; cl00919 320373009427 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 320373009428 putative active site pocket [active] 320373009429 4-fold oligomerization interface [polypeptide binding]; other site 320373009430 metal binding residues [ion binding]; metal-binding site 320373009431 3-fold/trimer interface [polypeptide binding]; other site 320373009432 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 320373009433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373009434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373009435 homodimer interface [polypeptide binding]; other site 320373009436 catalytic residue [active] 320373009437 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 320373009438 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 320373009439 NAD binding site [chemical binding]; other site 320373009440 dimerization interface [polypeptide binding]; other site 320373009441 product binding site; other site 320373009442 substrate binding site [chemical binding]; other site 320373009443 zinc binding site [ion binding]; other site 320373009444 catalytic residues [active] 320373009445 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 320373009446 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 320373009447 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 320373009448 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 320373009449 hinge; other site 320373009450 active site 320373009451 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 320373009452 ABC-2 type transporter; Region: ABC2_membrane; cl17235 320373009453 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320373009454 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 320373009455 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 320373009456 Walker A/P-loop; other site 320373009457 ATP binding site [chemical binding]; other site 320373009458 Q-loop/lid; other site 320373009459 ABC transporter signature motif; other site 320373009460 Walker B; other site 320373009461 D-loop; other site 320373009462 H-loop/switch region; other site 320373009463 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 320373009464 anti sigma factor interaction site; other site 320373009465 regulatory phosphorylation site [posttranslational modification]; other site 320373009466 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 320373009467 VacJ like lipoprotein; Region: VacJ; cl01073 320373009468 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 320373009469 mce related protein; Region: MCE; pfam02470 320373009470 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 320373009471 Permease; Region: Permease; pfam02405 320373009472 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 320373009473 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 320373009474 Walker A/P-loop; other site 320373009475 ATP binding site [chemical binding]; other site 320373009476 Q-loop/lid; other site 320373009477 ABC transporter signature motif; other site 320373009478 Walker B; other site 320373009479 D-loop; other site 320373009480 H-loop/switch region; other site 320373009481 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 320373009482 thiamine phosphate binding site [chemical binding]; other site 320373009483 active site 320373009484 pyrophosphate binding site [ion binding]; other site 320373009485 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 320373009486 ThiS interaction site; other site 320373009487 putative active site [active] 320373009488 tetramer interface [polypeptide binding]; other site 320373009489 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 320373009490 thiS-thiF/thiG interaction site; other site 320373009491 FAD dependent oxidoreductase; Region: DAO; pfam01266 320373009492 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 320373009493 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 320373009494 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 320373009495 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 320373009496 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 320373009497 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 320373009498 amino acid carrier protein; Region: agcS; TIGR00835 320373009499 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 320373009500 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373009501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373009502 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 320373009503 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 320373009504 active site 320373009505 dimer interface [polypeptide binding]; other site 320373009506 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 320373009507 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 320373009508 active site 320373009509 FMN binding site [chemical binding]; other site 320373009510 substrate binding site [chemical binding]; other site 320373009511 3Fe-4S cluster binding site [ion binding]; other site 320373009512 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 320373009513 domain interface; other site 320373009514 Transposase IS200 like; Region: Y1_Tnp; cl00848 320373009515 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320373009516 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 320373009517 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 320373009518 active site 320373009519 catalytic site [active] 320373009520 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 320373009521 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 320373009522 Walker A/P-loop; other site 320373009523 ATP binding site [chemical binding]; other site 320373009524 Q-loop/lid; other site 320373009525 ABC transporter signature motif; other site 320373009526 Walker B; other site 320373009527 D-loop; other site 320373009528 H-loop/switch region; other site 320373009529 TOBE domain; Region: TOBE_2; pfam08402 320373009530 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 320373009531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373009532 dimer interface [polypeptide binding]; other site 320373009533 conserved gate region; other site 320373009534 putative PBP binding loops; other site 320373009535 ABC-ATPase subunit interface; other site 320373009536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373009537 dimer interface [polypeptide binding]; other site 320373009538 conserved gate region; other site 320373009539 putative PBP binding loops; other site 320373009540 ABC-ATPase subunit interface; other site 320373009541 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 320373009542 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 320373009543 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 320373009544 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320373009545 Zn2+ binding site [ion binding]; other site 320373009546 Mg2+ binding site [ion binding]; other site 320373009547 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 320373009548 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 320373009549 active site 320373009550 dimer interface [polypeptide binding]; other site 320373009551 metal binding site [ion binding]; metal-binding site 320373009552 shikimate kinase; Reviewed; Region: aroK; PRK00131 320373009553 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 320373009554 ADP binding site [chemical binding]; other site 320373009555 magnesium binding site [ion binding]; other site 320373009556 putative shikimate binding site; other site 320373009557 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 320373009558 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373009559 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373009560 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 320373009561 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 320373009562 Transglycosylase; Region: Transgly; pfam00912 320373009563 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320373009564 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 320373009565 putative iron binding site [ion binding]; other site 320373009566 diaminopimelate decarboxylase; Region: lysA; TIGR01048 320373009567 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 320373009568 active site 320373009569 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320373009570 substrate binding site [chemical binding]; other site 320373009571 catalytic residues [active] 320373009572 dimer interface [polypeptide binding]; other site 320373009573 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 320373009574 TMAO/DMSO reductase; Reviewed; Region: PRK05363 320373009575 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 320373009576 Moco binding site; other site 320373009577 metal coordination site [ion binding]; other site 320373009578 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 320373009579 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 320373009580 ResB-like family; Region: ResB; pfam05140 320373009581 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 320373009582 ResB-like family; Region: ResB; pfam05140 320373009583 Cytochrome c553 [Energy production and conversion]; Region: COG2863 320373009584 Cytochrome c; Region: Cytochrom_C; cl11414 320373009585 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 320373009586 G1 box; other site 320373009587 GTP/Mg2+ binding site [chemical binding]; other site 320373009588 Switch I region; other site 320373009589 G2 box; other site 320373009590 G3 box; other site 320373009591 Switch II region; other site 320373009592 G4 box; other site 320373009593 G5 box; other site 320373009594 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 320373009595 dimer interface [polypeptide binding]; other site 320373009596 active site 320373009597 aspartate-rich active site metal binding site; other site 320373009598 allosteric magnesium binding site [ion binding]; other site 320373009599 Schiff base residues; other site 320373009600 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 320373009601 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 320373009602 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 320373009603 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 320373009604 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320373009605 DsbD alpha interface [polypeptide binding]; other site 320373009606 catalytic residues [active] 320373009607 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 320373009608 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 320373009609 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 320373009610 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 320373009611 alphaNTD homodimer interface [polypeptide binding]; other site 320373009612 alphaNTD - beta interaction site [polypeptide binding]; other site 320373009613 alphaNTD - beta' interaction site [polypeptide binding]; other site 320373009614 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 320373009615 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 320373009616 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 320373009617 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 320373009618 RNA binding surface [nucleotide binding]; other site 320373009619 30S ribosomal protein S11; Validated; Region: PRK05309 320373009620 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 320373009621 30S ribosomal protein S13; Region: bact_S13; TIGR03631 320373009622 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 320373009623 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 320373009624 rRNA binding site [nucleotide binding]; other site 320373009625 predicted 30S ribosome binding site; other site 320373009626 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 320373009627 SecY translocase; Region: SecY; pfam00344 320373009628 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 320373009629 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 320373009630 23S rRNA binding site [nucleotide binding]; other site 320373009631 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 320373009632 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 320373009633 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 320373009634 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 320373009635 5S rRNA interface [nucleotide binding]; other site 320373009636 L27 interface [polypeptide binding]; other site 320373009637 23S rRNA interface [nucleotide binding]; other site 320373009638 L5 interface [polypeptide binding]; other site 320373009639 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 320373009640 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 320373009641 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 320373009642 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 320373009643 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 320373009644 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 320373009645 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 320373009646 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 320373009647 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 320373009648 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 320373009649 RNA binding site [nucleotide binding]; other site 320373009650 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 320373009651 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 320373009652 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 320373009653 23S rRNA interface [nucleotide binding]; other site 320373009654 putative translocon interaction site; other site 320373009655 signal recognition particle (SRP54) interaction site; other site 320373009656 L23 interface [polypeptide binding]; other site 320373009657 trigger factor interaction site; other site 320373009658 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 320373009659 23S rRNA interface [nucleotide binding]; other site 320373009660 5S rRNA interface [nucleotide binding]; other site 320373009661 putative antibiotic binding site [chemical binding]; other site 320373009662 L25 interface [polypeptide binding]; other site 320373009663 L27 interface [polypeptide binding]; other site 320373009664 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 320373009665 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 320373009666 G-X-X-G motif; other site 320373009667 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 320373009668 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 320373009669 putative translocon binding site; other site 320373009670 protein-rRNA interface [nucleotide binding]; other site 320373009671 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 320373009672 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 320373009673 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 320373009674 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 320373009675 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 320373009676 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 320373009677 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 320373009678 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 320373009679 elongation factor Tu; Reviewed; Region: PRK00049 320373009680 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 320373009681 G1 box; other site 320373009682 GEF interaction site [polypeptide binding]; other site 320373009683 GTP/Mg2+ binding site [chemical binding]; other site 320373009684 Switch I region; other site 320373009685 G2 box; other site 320373009686 G3 box; other site 320373009687 Switch II region; other site 320373009688 G4 box; other site 320373009689 G5 box; other site 320373009690 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 320373009691 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 320373009692 Antibiotic Binding Site [chemical binding]; other site 320373009693 elongation factor G; Reviewed; Region: PRK00007 320373009694 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 320373009695 G1 box; other site 320373009696 putative GEF interaction site [polypeptide binding]; other site 320373009697 GTP/Mg2+ binding site [chemical binding]; other site 320373009698 Switch I region; other site 320373009699 G2 box; other site 320373009700 G3 box; other site 320373009701 Switch II region; other site 320373009702 G4 box; other site 320373009703 G5 box; other site 320373009704 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 320373009705 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 320373009706 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 320373009707 30S ribosomal protein S7; Validated; Region: PRK05302 320373009708 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 320373009709 S17 interaction site [polypeptide binding]; other site 320373009710 S8 interaction site; other site 320373009711 16S rRNA interaction site [nucleotide binding]; other site 320373009712 streptomycin interaction site [chemical binding]; other site 320373009713 23S rRNA interaction site [nucleotide binding]; other site 320373009714 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 320373009715 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 320373009716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320373009717 ATP binding site [chemical binding]; other site 320373009718 putative Mg++ binding site [ion binding]; other site 320373009719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373009720 nucleotide binding region [chemical binding]; other site 320373009721 ATP-binding site [chemical binding]; other site 320373009722 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 320373009723 HRDC domain; Region: HRDC; pfam00570 320373009724 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 320373009725 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 320373009726 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 320373009727 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 320373009728 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 320373009729 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 320373009730 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 320373009731 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 320373009732 DNA binding site [nucleotide binding] 320373009733 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 320373009734 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 320373009735 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 320373009736 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 320373009737 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 320373009738 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 320373009739 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 320373009740 RPB3 interaction site [polypeptide binding]; other site 320373009741 RPB1 interaction site [polypeptide binding]; other site 320373009742 RPB11 interaction site [polypeptide binding]; other site 320373009743 RPB10 interaction site [polypeptide binding]; other site 320373009744 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 320373009745 peripheral dimer interface [polypeptide binding]; other site 320373009746 core dimer interface [polypeptide binding]; other site 320373009747 L10 interface [polypeptide binding]; other site 320373009748 L11 interface [polypeptide binding]; other site 320373009749 putative EF-Tu interaction site [polypeptide binding]; other site 320373009750 putative EF-G interaction site [polypeptide binding]; other site 320373009751 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 320373009752 23S rRNA interface [nucleotide binding]; other site 320373009753 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 320373009754 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 320373009755 mRNA/rRNA interface [nucleotide binding]; other site 320373009756 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 320373009757 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 320373009758 23S rRNA interface [nucleotide binding]; other site 320373009759 L7/L12 interface [polypeptide binding]; other site 320373009760 putative thiostrepton binding site; other site 320373009761 L25 interface [polypeptide binding]; other site 320373009762 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 320373009763 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 320373009764 putative homodimer interface [polypeptide binding]; other site 320373009765 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 320373009766 heterodimer interface [polypeptide binding]; other site 320373009767 homodimer interface [polypeptide binding]; other site 320373009768 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 320373009769 elongation factor Tu; Reviewed; Region: PRK00049 320373009770 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 320373009771 G1 box; other site 320373009772 GEF interaction site [polypeptide binding]; other site 320373009773 GTP/Mg2+ binding site [chemical binding]; other site 320373009774 Switch I region; other site 320373009775 G2 box; other site 320373009776 G3 box; other site 320373009777 Switch II region; other site 320373009778 G4 box; other site 320373009779 G5 box; other site 320373009780 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 320373009781 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 320373009782 Antibiotic Binding Site [chemical binding]; other site 320373009783 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 320373009784 catalytic triad [active] 320373009785 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 320373009786 active site 320373009787 oxyanion hole [active] 320373009788 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 320373009789 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 320373009790 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 320373009791 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 320373009792 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 320373009793 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 320373009794 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 320373009795 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 320373009796 FAD binding pocket [chemical binding]; other site 320373009797 FAD binding motif [chemical binding]; other site 320373009798 phosphate binding motif [ion binding]; other site 320373009799 beta-alpha-beta structure motif; other site 320373009800 NAD(p) ribose binding residues [chemical binding]; other site 320373009801 NAD binding pocket [chemical binding]; other site 320373009802 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 320373009803 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373009804 catalytic loop [active] 320373009805 iron binding site [ion binding]; other site 320373009806 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 320373009807 Protein of unknown function; Region: DUF3658; pfam12395 320373009808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373009809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373009810 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 320373009811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373009812 Coenzyme A binding pocket [chemical binding]; other site 320373009813 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373009814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373009815 putative DNA binding site [nucleotide binding]; other site 320373009816 putative Zn2+ binding site [ion binding]; other site 320373009817 AsnC family; Region: AsnC_trans_reg; pfam01037 320373009818 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 320373009819 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 320373009820 dimer interface [polypeptide binding]; other site 320373009821 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 320373009822 active site 320373009823 Fe binding site [ion binding]; other site 320373009824 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 320373009825 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 320373009826 dimer interface [polypeptide binding]; other site 320373009827 PYR/PP interface [polypeptide binding]; other site 320373009828 TPP binding site [chemical binding]; other site 320373009829 substrate binding site [chemical binding]; other site 320373009830 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 320373009831 TPP-binding site; other site 320373009832 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 320373009833 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 320373009834 Malic enzyme, N-terminal domain; Region: malic; pfam00390 320373009835 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 320373009836 putative NAD(P) binding site [chemical binding]; other site 320373009837 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 320373009838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373009839 active site 320373009840 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 320373009841 substrate binding site [chemical binding]; other site 320373009842 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 320373009843 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320373009844 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 320373009845 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 320373009846 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320373009847 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 320373009848 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320373009849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373009850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373009851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373009852 dimerization interface [polypeptide binding]; other site 320373009853 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373009854 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 320373009855 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 320373009856 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 320373009857 Uncharacterized conserved protein [Function unknown]; Region: COG1656 320373009858 Protein of unknown function DUF82; Region: DUF82; pfam01927 320373009859 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 320373009860 Spore germination protein; Region: Spore_permease; cl17796 320373009861 Cytochrome c; Region: Cytochrom_C; cl11414 320373009862 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 320373009863 BON domain; Region: BON; pfam04972 320373009864 BON domain; Region: BON; pfam04972 320373009865 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 320373009866 dimer interface [polypeptide binding]; other site 320373009867 active site 320373009868 hypothetical protein; Provisional; Region: PRK14673 320373009869 Predicted methyltransferases [General function prediction only]; Region: COG0313 320373009870 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 320373009871 putative SAM binding site [chemical binding]; other site 320373009872 putative homodimer interface [polypeptide binding]; other site 320373009873 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 320373009874 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 320373009875 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 320373009876 active site 320373009877 catalytic site [active] 320373009878 substrate binding site [chemical binding]; other site 320373009879 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 320373009880 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373009881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373009882 putative DNA binding site [nucleotide binding]; other site 320373009883 putative Zn2+ binding site [ion binding]; other site 320373009884 AsnC family; Region: AsnC_trans_reg; pfam01037 320373009885 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 320373009886 Cation efflux family; Region: Cation_efflux; pfam01545 320373009887 H-NS histone family; Region: Histone_HNS; pfam00816 320373009888 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373009889 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 320373009890 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320373009891 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320373009892 dimerization interface [polypeptide binding]; other site 320373009893 ligand binding site [chemical binding]; other site 320373009894 Nitronate monooxygenase; Region: NMO; pfam03060 320373009895 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 320373009896 FMN binding site [chemical binding]; other site 320373009897 substrate binding site [chemical binding]; other site 320373009898 putative catalytic residue [active] 320373009899 Dienelactone hydrolase family; Region: DLH; pfam01738 320373009900 amidase; Provisional; Region: PRK07869 320373009901 Amidase; Region: Amidase; cl11426 320373009902 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 320373009903 FAD binding site [chemical binding]; other site 320373009904 Predicted membrane protein [Function unknown]; Region: COG1950 320373009905 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 320373009906 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 320373009907 homotetramer interface [polypeptide binding]; other site 320373009908 ligand binding site [chemical binding]; other site 320373009909 catalytic site [active] 320373009910 NAD binding site [chemical binding]; other site 320373009911 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 320373009912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373009913 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 320373009914 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373009915 DNA binding residues [nucleotide binding] 320373009916 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 320373009917 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 320373009918 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 320373009919 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 320373009920 FHIPEP family; Region: FHIPEP; pfam00771 320373009921 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 320373009922 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 320373009923 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 320373009924 dimer interface [polypeptide binding]; other site 320373009925 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 320373009926 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 320373009927 chemotaxis regulator CheZ; Provisional; Region: PRK11166 320373009928 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 320373009929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373009930 active site 320373009931 phosphorylation site [posttranslational modification] 320373009932 intermolecular recognition site; other site 320373009933 dimerization interface [polypeptide binding]; other site 320373009934 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 320373009935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373009936 active site 320373009937 phosphorylation site [posttranslational modification] 320373009938 intermolecular recognition site; other site 320373009939 dimerization interface [polypeptide binding]; other site 320373009940 CheB methylesterase; Region: CheB_methylest; pfam01339 320373009941 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 320373009942 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 320373009943 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 320373009944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373009945 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 320373009946 dimer interface [polypeptide binding]; other site 320373009947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373009948 dimerization interface [polypeptide binding]; other site 320373009949 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320373009950 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373009951 dimer interface [polypeptide binding]; other site 320373009952 putative CheW interface [polypeptide binding]; other site 320373009953 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 320373009954 putative CheA interaction surface; other site 320373009955 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 320373009956 putative binding surface; other site 320373009957 active site 320373009958 CheY binding; Region: CheY-binding; pfam09078 320373009959 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 320373009960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373009961 ATP binding site [chemical binding]; other site 320373009962 Mg2+ binding site [ion binding]; other site 320373009963 G-X-G motif; other site 320373009964 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 320373009965 Response regulator receiver domain; Region: Response_reg; pfam00072 320373009966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373009967 active site 320373009968 phosphorylation site [posttranslational modification] 320373009969 intermolecular recognition site; other site 320373009970 dimerization interface [polypeptide binding]; other site 320373009971 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 320373009972 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 320373009973 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373009974 ligand binding site [chemical binding]; other site 320373009975 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 320373009976 flagellar motor protein MotA; Validated; Region: PRK09110 320373009977 transcriptional activator FlhC; Provisional; Region: PRK12722 320373009978 transcriptional activator FlhD; Provisional; Region: PRK02909 320373009979 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373009980 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 320373009981 putative ADP-binding pocket [chemical binding]; other site 320373009982 H-NS histone family; Region: Histone_HNS; pfam00816 320373009983 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373009984 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 320373009985 amphipathic channel; other site 320373009986 Asn-Pro-Ala signature motifs; other site 320373009987 putative hydrolase; Provisional; Region: PRK10976 320373009988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373009989 active site 320373009990 motif I; other site 320373009991 motif II; other site 320373009992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373009993 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 320373009994 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 320373009995 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 320373009996 flagellin; Reviewed; Region: PRK08869 320373009997 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 320373009998 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 320373009999 flagellar capping protein; Reviewed; Region: fliD; PRK08032 320373010000 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 320373010001 Tetratricopeptide repeat; Region: TPR_16; pfam13432 320373010002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373010003 TPR motif; other site 320373010004 binding surface 320373010005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373010006 binding surface 320373010007 TPR motif; other site 320373010008 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 320373010009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373010010 TPR motif; other site 320373010011 binding surface 320373010012 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 320373010013 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 320373010014 inhibitor-cofactor binding pocket; inhibition site 320373010015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373010016 catalytic residue [active] 320373010017 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 320373010018 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 320373010019 dimer interface [polypeptide binding]; other site 320373010020 active site 320373010021 CoA binding pocket [chemical binding]; other site 320373010022 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 320373010023 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 320373010024 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 320373010025 dimer interface [polypeptide binding]; other site 320373010026 active site 320373010027 CoA binding pocket [chemical binding]; other site 320373010028 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320373010029 classical (c) SDRs; Region: SDR_c; cd05233 320373010030 NAD(P) binding site [chemical binding]; other site 320373010031 active site 320373010032 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 320373010033 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 320373010034 putative trimer interface [polypeptide binding]; other site 320373010035 putative CoA binding site [chemical binding]; other site 320373010036 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320373010037 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320373010038 [2Fe-2S] cluster binding site [ion binding]; other site 320373010039 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 320373010040 alpha subunit interface [polypeptide binding]; other site 320373010041 active site 320373010042 substrate binding site [chemical binding]; other site 320373010043 Fe binding site [ion binding]; other site 320373010044 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373010045 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373010046 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 320373010047 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 320373010048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 320373010049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 320373010050 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 320373010051 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 320373010052 Cache domain; Region: Cache_1; pfam02743 320373010053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373010054 dimerization interface [polypeptide binding]; other site 320373010055 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320373010056 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373010057 dimer interface [polypeptide binding]; other site 320373010058 putative CheW interface [polypeptide binding]; other site 320373010059 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320373010060 FAD binding domain; Region: FAD_binding_4; pfam01565 320373010061 Berberine and berberine like; Region: BBE; pfam08031 320373010062 Chitin binding domain; Region: Chitin_bind_3; pfam03067 320373010063 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 320373010064 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 320373010065 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373010066 DNA binding site [nucleotide binding] 320373010067 active site 320373010068 Int/Topo IB signature motif; other site 320373010069 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373010070 DNA binding site [nucleotide binding] 320373010071 active site 320373010072 Int/Topo IB signature motif; other site 320373010073 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 320373010074 Domain of unknown function (DUF955); Region: DUF955; cl01076 320373010075 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373010076 Zonular occludens toxin (Zot); Region: Zot; cl17485 320373010077 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320373010078 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 320373010079 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 320373010080 Cytochrome c; Region: Cytochrom_C; cl11414 320373010081 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 320373010082 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 320373010083 Part of AAA domain; Region: AAA_19; pfam13245 320373010084 Family description; Region: UvrD_C_2; pfam13538 320373010085 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 320373010086 oxyanion hole [active] 320373010087 active site 320373010088 catalytic triad [active] 320373010089 putative oxidoreductase; Provisional; Region: PRK11579 320373010090 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 320373010091 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 320373010092 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 320373010093 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 320373010094 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 320373010095 lipoyl attachment site [posttranslational modification]; other site 320373010096 glycine dehydrogenase; Provisional; Region: PRK05367 320373010097 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 320373010098 tetramer interface [polypeptide binding]; other site 320373010099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373010100 catalytic residue [active] 320373010101 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 320373010102 tetramer interface [polypeptide binding]; other site 320373010103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373010104 catalytic residue [active] 320373010105 Alginate lyase; Region: Alginate_lyase; pfam05426 320373010106 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 320373010107 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 320373010108 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 320373010109 thiamine pyrophosphate protein; Validated; Region: PRK08199 320373010110 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373010111 PYR/PP interface [polypeptide binding]; other site 320373010112 dimer interface [polypeptide binding]; other site 320373010113 TPP binding site [chemical binding]; other site 320373010114 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373010115 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 320373010116 TPP-binding site [chemical binding]; other site 320373010117 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373010118 Helix-turn-helix domain; Region: HTH_18; pfam12833 320373010119 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 320373010120 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320373010121 NAD(P) binding site [chemical binding]; other site 320373010122 catalytic residues [active] 320373010123 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 320373010124 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 320373010125 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 320373010126 ethanolamine permease; Region: 2A0305; TIGR00908 320373010127 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 320373010128 Acyltransferase family; Region: Acyl_transf_3; pfam01757 320373010129 Conserved TM helix; Region: TM_helix; pfam05552 320373010130 Conserved TM helix; Region: TM_helix; pfam05552 320373010131 Conserved TM helix; Region: TM_helix; pfam05552 320373010132 Double zinc ribbon; Region: DZR; pfam12773 320373010133 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 320373010134 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320373010135 Soluble P-type ATPase [General function prediction only]; Region: COG4087 320373010136 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 320373010137 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 320373010138 DNA binding residues [nucleotide binding] 320373010139 dimer interface [polypeptide binding]; other site 320373010140 putative metal binding site [ion binding]; other site 320373010141 Predicted transcriptional regulators [Transcription]; Region: COG1695 320373010142 Transcriptional regulator PadR-like family; Region: PadR; cl17335 320373010143 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 320373010144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373010145 substrate binding pocket [chemical binding]; other site 320373010146 membrane-bound complex binding site; other site 320373010147 hinge residues; other site 320373010148 putative aminotransferase; Provisional; Region: PRK12414 320373010149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373010150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373010151 homodimer interface [polypeptide binding]; other site 320373010152 catalytic residue [active] 320373010153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373010154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373010155 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 320373010156 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373010157 active site 320373010158 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 320373010159 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373010160 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 320373010161 acyl-activating enzyme (AAE) consensus motif; other site 320373010162 acyl-activating enzyme (AAE) consensus motif; other site 320373010163 putative AMP binding site [chemical binding]; other site 320373010164 putative active site [active] 320373010165 putative CoA binding site [chemical binding]; other site 320373010166 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320373010167 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320373010168 dimerization interface [polypeptide binding]; other site 320373010169 ligand binding site [chemical binding]; other site 320373010170 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 320373010171 Predicted transcriptional regulator [Transcription]; Region: COG3905 320373010172 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 320373010173 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 320373010174 Glutamate binding site [chemical binding]; other site 320373010175 NAD binding site [chemical binding]; other site 320373010176 catalytic residues [active] 320373010177 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320373010178 NAD(P) binding site [chemical binding]; other site 320373010179 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373010180 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 320373010181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320373010182 ATP binding site [chemical binding]; other site 320373010183 putative Mg++ binding site [ion binding]; other site 320373010184 nucleotide binding region [chemical binding]; other site 320373010185 helicase superfamily c-terminal domain; Region: HELICc; smart00490 320373010186 ATP-binding site [chemical binding]; other site 320373010187 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 320373010188 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 320373010189 substrate binding site [chemical binding]; other site 320373010190 active site 320373010191 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373010192 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320373010193 substrate binding pocket [chemical binding]; other site 320373010194 membrane-bound complex binding site; other site 320373010195 hinge residues; other site 320373010196 CoA binding domain; Region: CoA_binding; cl17356 320373010197 AMP-binding domain protein; Validated; Region: PRK08315 320373010198 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373010199 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 320373010200 acyl-activating enzyme (AAE) consensus motif; other site 320373010201 putative AMP binding site [chemical binding]; other site 320373010202 putative active site [active] 320373010203 putative CoA binding site [chemical binding]; other site 320373010204 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 320373010205 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 320373010206 gamma subunit interface [polypeptide binding]; other site 320373010207 epsilon subunit interface [polypeptide binding]; other site 320373010208 LBP interface [polypeptide binding]; other site 320373010209 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 320373010210 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320373010211 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 320373010212 alpha subunit interaction interface [polypeptide binding]; other site 320373010213 Walker A motif; other site 320373010214 ATP binding site [chemical binding]; other site 320373010215 Walker B motif; other site 320373010216 inhibitor binding site; inhibition site 320373010217 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320373010218 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 320373010219 core domain interface [polypeptide binding]; other site 320373010220 delta subunit interface [polypeptide binding]; other site 320373010221 epsilon subunit interface [polypeptide binding]; other site 320373010222 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 320373010223 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320373010224 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 320373010225 beta subunit interaction interface [polypeptide binding]; other site 320373010226 Walker A motif; other site 320373010227 ATP binding site [chemical binding]; other site 320373010228 Walker B motif; other site 320373010229 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320373010230 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 320373010231 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 320373010232 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 320373010233 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 320373010234 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 320373010235 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 320373010236 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 320373010237 ATP synthase I chain; Region: ATP_synt_I; cl09170 320373010238 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 320373010239 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 320373010240 transmembrane helices; other site 320373010241 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 320373010242 ParB-like nuclease domain; Region: ParBc; pfam02195 320373010243 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 320373010244 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320373010245 P-loop; other site 320373010246 Magnesium ion binding site [ion binding]; other site 320373010247 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320373010248 Magnesium ion binding site [ion binding]; other site 320373010249 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 320373010250 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 320373010251 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 320373010252 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 320373010253 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 320373010254 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 320373010255 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320373010256 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320373010257 Walker A/P-loop; other site 320373010258 ATP binding site [chemical binding]; other site 320373010259 Q-loop/lid; other site 320373010260 ABC transporter signature motif; other site 320373010261 Walker B; other site 320373010262 D-loop; other site 320373010263 H-loop/switch region; other site 320373010264 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320373010265 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320373010266 TM-ABC transporter signature motif; other site 320373010267 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320373010268 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320373010269 Walker A/P-loop; other site 320373010270 ATP binding site [chemical binding]; other site 320373010271 Q-loop/lid; other site 320373010272 ABC transporter signature motif; other site 320373010273 Walker B; other site 320373010274 D-loop; other site 320373010275 H-loop/switch region; other site 320373010276 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320373010277 TM-ABC transporter signature motif; other site 320373010278 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320373010279 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 320373010280 putative ligand binding site [chemical binding]; other site 320373010281 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 320373010282 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 320373010283 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320373010284 TM-ABC transporter signature motif; other site 320373010285 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373010286 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320373010287 TM-ABC transporter signature motif; other site 320373010288 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 320373010289 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 320373010290 putative ligand binding site [chemical binding]; other site 320373010291 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320373010292 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320373010293 Walker A/P-loop; other site 320373010294 ATP binding site [chemical binding]; other site 320373010295 Q-loop/lid; other site 320373010296 ABC transporter signature motif; other site 320373010297 Walker B; other site 320373010298 D-loop; other site 320373010299 H-loop/switch region; other site 320373010300 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320373010301 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320373010302 Walker A/P-loop; other site 320373010303 ATP binding site [chemical binding]; other site 320373010304 Q-loop/lid; other site 320373010305 ABC transporter signature motif; other site 320373010306 Walker B; other site 320373010307 D-loop; other site 320373010308 H-loop/switch region; other site 320373010309 choline dehydrogenase; Validated; Region: PRK02106 320373010310 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320373010311 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 320373010312 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 320373010313 tetrameric interface [polypeptide binding]; other site 320373010314 NAD binding site [chemical binding]; other site 320373010315 catalytic residues [active] 320373010316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373010317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373010318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373010319 dimerization interface [polypeptide binding]; other site 320373010320 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 320373010321 putative active site [active] 320373010322 putative metal binding residues [ion binding]; other site 320373010323 signature motif; other site 320373010324 putative triphosphate binding site [ion binding]; other site 320373010325 dimer interface [polypeptide binding]; other site 320373010326 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373010327 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 320373010328 putative DNA binding site [nucleotide binding]; other site 320373010329 putative Zn2+ binding site [ion binding]; other site 320373010330 AsnC family; Region: AsnC_trans_reg; pfam01037 320373010331 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 320373010332 cofactor binding site; other site 320373010333 metal binding site [ion binding]; metal-binding site 320373010334 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 320373010335 aromatic arch; other site 320373010336 DCoH dimer interaction site [polypeptide binding]; other site 320373010337 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 320373010338 DCoH tetramer interaction site [polypeptide binding]; other site 320373010339 substrate binding site [chemical binding]; other site 320373010340 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 320373010341 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373010342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010343 active site 320373010344 phosphorylation site [posttranslational modification] 320373010345 intermolecular recognition site; other site 320373010346 dimerization interface [polypeptide binding]; other site 320373010347 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373010348 DNA binding site [nucleotide binding] 320373010349 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 320373010350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373010351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373010352 dimer interface [polypeptide binding]; other site 320373010353 phosphorylation site [posttranslational modification] 320373010354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373010355 ATP binding site [chemical binding]; other site 320373010356 Mg2+ binding site [ion binding]; other site 320373010357 G-X-G motif; other site 320373010358 Proteins containing SET domain [General function prediction only]; Region: COG2940 320373010359 SET domain; Region: SET; pfam00856 320373010360 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320373010361 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 320373010362 active site 320373010363 FMN binding site [chemical binding]; other site 320373010364 substrate binding site [chemical binding]; other site 320373010365 homotetramer interface [polypeptide binding]; other site 320373010366 catalytic residue [active] 320373010367 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 320373010368 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 320373010369 catalytic triad [active] 320373010370 Transcriptional regulators [Transcription]; Region: MarR; COG1846 320373010371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373010372 putative DNA binding site [nucleotide binding]; other site 320373010373 putative Zn2+ binding site [ion binding]; other site 320373010374 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 320373010375 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 320373010376 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 320373010377 active site 320373010378 Int/Topo IB signature motif; other site 320373010379 catalytic residues [active] 320373010380 DNA binding site [nucleotide binding] 320373010381 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 320373010382 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 320373010383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373010384 non-specific DNA binding site [nucleotide binding]; other site 320373010385 salt bridge; other site 320373010386 sequence-specific DNA binding site [nucleotide binding]; other site 320373010387 Cupin domain; Region: Cupin_2; pfam07883 320373010388 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 320373010389 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 320373010390 substrate-cofactor binding pocket; other site 320373010391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373010392 catalytic residue [active] 320373010393 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 320373010394 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320373010395 NAD(P) binding site [chemical binding]; other site 320373010396 Uncharacterized conserved protein [Function unknown]; Region: COG2353 320373010397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373010398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373010399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 320373010400 SnoaL-like domain; Region: SnoaL_2; pfam12680 320373010401 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 320373010402 putative active site [active] 320373010403 Zn binding site [ion binding]; other site 320373010404 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 320373010405 tartrate dehydrogenase; Region: TTC; TIGR02089 320373010406 Phospholipid methyltransferase; Region: PEMT; cl17370 320373010407 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320373010408 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 320373010409 putative C-terminal domain interface [polypeptide binding]; other site 320373010410 putative GSH binding site (G-site) [chemical binding]; other site 320373010411 putative dimer interface [polypeptide binding]; other site 320373010412 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 320373010413 putative N-terminal domain interface [polypeptide binding]; other site 320373010414 putative dimer interface [polypeptide binding]; other site 320373010415 putative substrate binding pocket (H-site) [chemical binding]; other site 320373010416 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 320373010417 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 320373010418 nucleophile elbow; other site 320373010419 Patatin phospholipase; Region: DUF3734; pfam12536 320373010420 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 320373010421 classical (c) SDRs; Region: SDR_c; cd05233 320373010422 NAD(P) binding site [chemical binding]; other site 320373010423 active site 320373010424 acetoacetate decarboxylase; Provisional; Region: PRK02265 320373010425 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 320373010426 active site 320373010427 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 320373010428 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 320373010429 FAD binding pocket [chemical binding]; other site 320373010430 FAD binding motif [chemical binding]; other site 320373010431 phosphate binding motif [ion binding]; other site 320373010432 NAD binding pocket [chemical binding]; other site 320373010433 Predicted transcriptional regulators [Transcription]; Region: COG1695 320373010434 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 320373010435 Beta protein; Region: Beta_protein; pfam14350 320373010436 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 320373010437 Domain of unknown function (DUF955); Region: DUF955; pfam06114 320373010438 Integrase core domain; Region: rve_3; pfam13683 320373010439 Transposase; Region: HTH_Tnp_1; pfam01527 320373010440 HTH-like domain; Region: HTH_21; pfam13276 320373010441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320373010442 Integrase core domain; Region: rve; pfam00665 320373010443 Integrase core domain; Region: rve_3; pfam13683 320373010444 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 320373010445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373010446 Walker A/P-loop; other site 320373010447 ATP binding site [chemical binding]; other site 320373010448 Syntaxin 6, N-terminal; Region: Syntaxin-6_N; pfam09177 320373010449 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 320373010450 putative active site [active] 320373010451 putative metal-binding site [ion binding]; other site 320373010452 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 320373010453 Part of AAA domain; Region: AAA_19; pfam13245 320373010454 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 320373010455 Family description; Region: UvrD_C_2; pfam13538 320373010456 Restriction endonuclease; Region: Mrr_cat; pfam04471 320373010457 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 320373010458 Cytochrome P450; Region: p450; cl12078 320373010459 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 320373010460 Protein of unknown function (DUF692); Region: DUF692; cl01263 320373010461 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 320373010462 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 320373010463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373010464 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 320373010465 FeS/SAM binding site; other site 320373010466 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373010467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373010468 S-adenosylmethionine binding site [chemical binding]; other site 320373010469 Lysine efflux permease [General function prediction only]; Region: COG1279 320373010470 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 320373010471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373010472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373010473 dimerization interface [polypeptide binding]; other site 320373010474 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 320373010475 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320373010476 ligand binding site [chemical binding]; other site 320373010477 flexible hinge region; other site 320373010478 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 320373010479 putative switch regulator; other site 320373010480 non-specific DNA interactions [nucleotide binding]; other site 320373010481 DNA binding site [nucleotide binding] 320373010482 sequence specific DNA binding site [nucleotide binding]; other site 320373010483 putative cAMP binding site [chemical binding]; other site 320373010484 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373010485 Ligand Binding Site [chemical binding]; other site 320373010486 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 320373010487 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 320373010488 dimer interface [polypeptide binding]; other site 320373010489 NADP binding site [chemical binding]; other site 320373010490 catalytic residues [active] 320373010491 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 320373010492 Strictosidine synthase; Region: Str_synth; pfam03088 320373010493 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 320373010494 Transcriptional activator HlyU; Region: HlyU; cl02273 320373010495 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 320373010496 serine O-acetyltransferase; Region: cysE; TIGR01172 320373010497 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 320373010498 trimer interface [polypeptide binding]; other site 320373010499 active site 320373010500 substrate binding site [chemical binding]; other site 320373010501 CoA binding site [chemical binding]; other site 320373010502 short chain dehydrogenase; Provisional; Region: PRK09134 320373010503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373010504 NAD(P) binding site [chemical binding]; other site 320373010505 active site 320373010506 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 320373010507 GTP cyclohydrolase I; Provisional; Region: PLN03044 320373010508 active site 320373010509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373010510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373010511 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 320373010512 substrate binding pocket [chemical binding]; other site 320373010513 dimerization interface [polypeptide binding]; other site 320373010514 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 320373010515 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320373010516 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 320373010517 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 320373010518 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 320373010519 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 320373010520 tetramer interface [polypeptide binding]; other site 320373010521 active site 320373010522 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 320373010523 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 320373010524 benzoate transport; Region: 2A0115; TIGR00895 320373010525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373010526 putative substrate translocation pore; other site 320373010527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373010528 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373010529 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 320373010530 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 320373010531 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373010532 DDE domain; Region: DDE_Tnp_IS240; pfam13610 320373010533 Uncharacterized conserved protein [Function unknown]; Region: COG3391 320373010534 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 320373010535 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 320373010536 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 320373010537 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 320373010538 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 320373010539 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 320373010540 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 320373010541 Chromate transporter; Region: Chromate_transp; pfam02417 320373010542 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 320373010543 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 320373010544 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 320373010545 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 320373010546 RNA polymerase sigma factor; Provisional; Region: PRK11922 320373010547 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373010548 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373010549 DNA binding residues [nucleotide binding] 320373010550 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 320373010551 H-NS histone family; Region: Histone_HNS; pfam00816 320373010552 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373010553 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 320373010554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373010555 putative substrate translocation pore; other site 320373010556 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 320373010557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373010558 dimer interface [polypeptide binding]; other site 320373010559 phosphorylation site [posttranslational modification] 320373010560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373010561 ATP binding site [chemical binding]; other site 320373010562 Mg2+ binding site [ion binding]; other site 320373010563 G-X-G motif; other site 320373010564 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320373010565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010566 active site 320373010567 phosphorylation site [posttranslational modification] 320373010568 intermolecular recognition site; other site 320373010569 dimerization interface [polypeptide binding]; other site 320373010570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373010571 Walker A motif; other site 320373010572 ATP binding site [chemical binding]; other site 320373010573 Walker B motif; other site 320373010574 arginine finger; other site 320373010575 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373010576 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 320373010577 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373010578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373010579 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 320373010580 Phosphoesterase family; Region: Phosphoesterase; pfam04185 320373010581 Domain of unknown function (DUF756); Region: DUF756; pfam05506 320373010582 Domain of unknown function (DUF756); Region: DUF756; pfam05506 320373010583 Integrase core domain; Region: rve_3; cl15866 320373010584 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 320373010585 Integrase core domain; Region: rve; pfam00665 320373010586 HTH-like domain; Region: HTH_21; pfam13276 320373010587 Integrase core domain; Region: rve; pfam00665 320373010588 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 320373010589 Helix-turn-helix domain; Region: HTH_18; pfam12833 320373010590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373010591 dimer interface [polypeptide binding]; other site 320373010592 conserved gate region; other site 320373010593 putative PBP binding loops; other site 320373010594 ABC-ATPase subunit interface; other site 320373010595 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 320373010596 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320373010597 H-NS histone family; Region: Histone_HNS; pfam00816 320373010598 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373010599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 320373010600 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373010601 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373010602 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 320373010603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 320373010604 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 320373010605 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 320373010606 Uncharacterized conserved protein [Function unknown]; Region: COG4104 320373010607 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 320373010608 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320373010609 catalytic residues [active] 320373010610 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 320373010611 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 320373010612 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 320373010613 Subunit I/III interface [polypeptide binding]; other site 320373010614 D-pathway; other site 320373010615 Subunit I/VIIc interface [polypeptide binding]; other site 320373010616 Subunit I/IV interface [polypeptide binding]; other site 320373010617 Subunit I/II interface [polypeptide binding]; other site 320373010618 Low-spin heme (heme a) binding site [chemical binding]; other site 320373010619 Subunit I/VIIa interface [polypeptide binding]; other site 320373010620 Subunit I/VIa interface [polypeptide binding]; other site 320373010621 Dimer interface; other site 320373010622 Putative water exit pathway; other site 320373010623 Binuclear center (heme a3/CuB) [ion binding]; other site 320373010624 K-pathway; other site 320373010625 Subunit I/Vb interface [polypeptide binding]; other site 320373010626 Putative proton exit pathway; other site 320373010627 Subunit I/VIb interface; other site 320373010628 Subunit I/VIc interface [polypeptide binding]; other site 320373010629 Electron transfer pathway; other site 320373010630 Subunit I/VIIIb interface [polypeptide binding]; other site 320373010631 Subunit I/VIIb interface [polypeptide binding]; other site 320373010632 Haemagglutinin; Region: HIM; pfam05662 320373010633 YadA-like C-terminal region; Region: YadA; pfam03895 320373010634 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 320373010635 YfaZ precursor; Region: YfaZ; pfam07437 320373010636 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 320373010637 putative chaperone protein EcpD; Provisional; Region: PRK09926 320373010638 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 320373010639 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 320373010640 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 320373010641 PapC N-terminal domain; Region: PapC_N; pfam13954 320373010642 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 320373010643 PapC C-terminal domain; Region: PapC_C; pfam13953 320373010644 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 320373010645 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 320373010646 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 320373010647 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373010648 ligand binding site [chemical binding]; other site 320373010649 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 320373010650 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 320373010651 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320373010652 Protein of unknown function (DUF796); Region: DUF796; pfam05638 320373010653 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 320373010654 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 320373010655 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320373010656 hypothetical protein; Provisional; Region: PRK08126 320373010657 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 320373010658 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373010659 ligand binding site [chemical binding]; other site 320373010660 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 320373010661 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320373010662 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320373010663 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320373010664 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373010665 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373010666 PAAR motif; Region: PAAR_motif; pfam05488 320373010667 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 320373010668 RHS Repeat; Region: RHS_repeat; cl11982 320373010669 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 320373010670 RHS Repeat; Region: RHS_repeat; cl11982 320373010671 RHS protein; Region: RHS; pfam03527 320373010672 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 320373010673 Fimbrial protein; Region: Fimbrial; pfam00419 320373010674 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 320373010675 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320373010676 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 320373010677 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320373010678 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 320373010679 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 320373010680 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 320373010681 ImpE protein; Region: ImpE; pfam07024 320373010682 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 320373010683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373010684 Walker A motif; other site 320373010685 ATP binding site [chemical binding]; other site 320373010686 Walker B motif; other site 320373010687 arginine finger; other site 320373010688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373010689 Walker A motif; other site 320373010690 ATP binding site [chemical binding]; other site 320373010691 Walker B motif; other site 320373010692 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320373010693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373010694 dimer interface [polypeptide binding]; other site 320373010695 phosphorylation site [posttranslational modification] 320373010696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373010697 ATP binding site [chemical binding]; other site 320373010698 Mg2+ binding site [ion binding]; other site 320373010699 G-X-G motif; other site 320373010700 Response regulator receiver domain; Region: Response_reg; pfam00072 320373010701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010702 active site 320373010703 phosphorylation site [posttranslational modification] 320373010704 intermolecular recognition site; other site 320373010705 dimerization interface [polypeptide binding]; other site 320373010706 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373010707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010708 active site 320373010709 phosphorylation site [posttranslational modification] 320373010710 intermolecular recognition site; other site 320373010711 dimerization interface [polypeptide binding]; other site 320373010712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373010713 DNA binding residues [nucleotide binding] 320373010714 dimerization interface [polypeptide binding]; other site 320373010715 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373010716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010717 active site 320373010718 phosphorylation site [posttranslational modification] 320373010719 intermolecular recognition site; other site 320373010720 dimerization interface [polypeptide binding]; other site 320373010721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373010722 DNA binding residues [nucleotide binding] 320373010723 dimerization interface [polypeptide binding]; other site 320373010724 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373010725 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320373010726 substrate binding pocket [chemical binding]; other site 320373010727 membrane-bound complex binding site; other site 320373010728 hinge residues; other site 320373010729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373010730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373010731 dimer interface [polypeptide binding]; other site 320373010732 phosphorylation site [posttranslational modification] 320373010733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373010734 ATP binding site [chemical binding]; other site 320373010735 Mg2+ binding site [ion binding]; other site 320373010736 G-X-G motif; other site 320373010737 Response regulator receiver domain; Region: Response_reg; pfam00072 320373010738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010739 active site 320373010740 phosphorylation site [posttranslational modification] 320373010741 intermolecular recognition site; other site 320373010742 dimerization interface [polypeptide binding]; other site 320373010743 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 320373010744 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 320373010745 active site 320373010746 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373010747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373010748 S-adenosylmethionine binding site [chemical binding]; other site 320373010749 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 320373010750 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 320373010751 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320373010752 active site 320373010753 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 320373010754 flagellin; Provisional; Region: PRK12802 320373010755 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 320373010756 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 320373010757 flagellar motor protein MotA; Provisional; Region: PRK12482 320373010758 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 320373010759 hypothetical protein; Validated; Region: PRK06778 320373010760 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 320373010761 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373010762 ligand binding site [chemical binding]; other site 320373010763 Response regulator receiver domain; Region: Response_reg; pfam00072 320373010764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010765 active site 320373010766 phosphorylation site [posttranslational modification] 320373010767 intermolecular recognition site; other site 320373010768 dimerization interface [polypeptide binding]; other site 320373010769 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 320373010770 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 320373010771 putative binding surface; other site 320373010772 active site 320373010773 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 320373010774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373010775 ATP binding site [chemical binding]; other site 320373010776 Mg2+ binding site [ion binding]; other site 320373010777 G-X-G motif; other site 320373010778 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 320373010779 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 320373010780 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373010781 dimer interface [polypeptide binding]; other site 320373010782 putative CheW interface [polypeptide binding]; other site 320373010783 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 320373010784 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 320373010785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373010786 CheD chemotactic sensory transduction; Region: CheD; cl00810 320373010787 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 320373010788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010789 active site 320373010790 phosphorylation site [posttranslational modification] 320373010791 intermolecular recognition site; other site 320373010792 dimerization interface [polypeptide binding]; other site 320373010793 CheB methylesterase; Region: CheB_methylest; pfam01339 320373010794 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 320373010795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010796 active site 320373010797 phosphorylation site [posttranslational modification] 320373010798 intermolecular recognition site; other site 320373010799 dimerization interface [polypeptide binding]; other site 320373010800 CheB methylesterase; Region: CheB_methylest; pfam01339 320373010801 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 320373010802 FHIPEP family; Region: FHIPEP; pfam00771 320373010803 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 320373010804 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 320373010805 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 320373010806 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 320373010807 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 320373010808 flagellar motor switch protein FliN; Region: fliN; TIGR02480 320373010809 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 320373010810 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 320373010811 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 320373010812 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 320373010813 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 320373010814 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 320373010815 FliG C-terminal domain; Region: FliG_C; pfam01706 320373010816 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 320373010817 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 320373010818 Flagellar assembly protein FliH; Region: FliH; pfam02108 320373010819 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 320373010820 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320373010821 Walker A motif; other site 320373010822 ATP binding site [chemical binding]; other site 320373010823 Walker B motif; other site 320373010824 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 320373010825 flagellar capping protein; Reviewed; Region: fliD; PRK08032 320373010826 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 320373010827 Flagellar protein FliS; Region: FliS; cl00654 320373010828 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 320373010829 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 320373010830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373010831 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 320373010832 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373010833 DNA binding residues [nucleotide binding] 320373010834 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 320373010835 FlgN protein; Region: FlgN; pfam05130 320373010836 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 320373010837 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 320373010838 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 320373010839 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 320373010840 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320373010841 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320373010842 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 320373010843 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 320373010844 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 320373010845 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 320373010846 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 320373010847 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 320373010848 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320373010849 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 320373010850 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 320373010851 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 320373010852 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320373010853 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 320373010854 Flagellar L-ring protein; Region: FlgH; pfam02107 320373010855 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 320373010856 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 320373010857 Rod binding protein; Region: Rod-binding; cl01626 320373010858 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 320373010859 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 320373010860 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 320373010861 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 320373010862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 320373010863 DNA binding site [nucleotide binding] 320373010864 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373010865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373010866 active site 320373010867 phosphorylation site [posttranslational modification] 320373010868 intermolecular recognition site; other site 320373010869 dimerization interface [polypeptide binding]; other site 320373010870 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373010871 DNA binding residues [nucleotide binding] 320373010872 dimerization interface [polypeptide binding]; other site 320373010873 H-NS histone family; Region: Histone_HNS; pfam00816 320373010874 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373010875 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 320373010876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373010877 putative substrate translocation pore; other site 320373010878 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 320373010879 pyruvate kinase; Provisional; Region: PRK06247 320373010880 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 320373010881 domain interfaces; other site 320373010882 active site 320373010883 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 320373010884 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 320373010885 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 320373010886 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 320373010887 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373010888 acyl-activating enzyme (AAE) consensus motif; other site 320373010889 AMP binding site [chemical binding]; other site 320373010890 active site 320373010891 CoA binding site [chemical binding]; other site 320373010892 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373010893 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 320373010894 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320373010895 extended (e) SDRs; Region: SDR_e; cd08946 320373010896 NAD(P) binding site [chemical binding]; other site 320373010897 active site 320373010898 substrate binding site [chemical binding]; other site 320373010899 SnoaL-like domain; Region: SnoaL_2; pfam12680 320373010900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 320373010901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373010902 S-adenosylmethionine binding site [chemical binding]; other site 320373010903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373010904 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320373010905 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320373010906 substrate binding pocket [chemical binding]; other site 320373010907 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 320373010908 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320373010909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373010910 metal binding site [ion binding]; metal-binding site 320373010911 active site 320373010912 I-site; other site 320373010913 mercuric reductase; Validated; Region: PRK06370 320373010914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373010915 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320373010916 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 320373010917 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320373010918 putative ligand binding site [chemical binding]; other site 320373010919 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373010920 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373010921 TM-ABC transporter signature motif; other site 320373010922 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 320373010923 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320373010924 Walker A/P-loop; other site 320373010925 ATP binding site [chemical binding]; other site 320373010926 Q-loop/lid; other site 320373010927 ABC transporter signature motif; other site 320373010928 Walker B; other site 320373010929 D-loop; other site 320373010930 H-loop/switch region; other site 320373010931 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320373010932 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 320373010933 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 320373010934 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 320373010935 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 320373010936 Domain interface; other site 320373010937 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 320373010938 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 320373010939 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 320373010940 starch-binding site 2 [chemical binding]; other site 320373010941 starch-binding site 1 [chemical binding]; other site 320373010942 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 320373010943 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 320373010944 ATP binding site [chemical binding]; other site 320373010945 Mg++ binding site [ion binding]; other site 320373010946 motif III; other site 320373010947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373010948 nucleotide binding region [chemical binding]; other site 320373010949 ATP-binding site [chemical binding]; other site 320373010950 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 320373010951 putative RNA binding site [nucleotide binding]; other site 320373010952 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373010953 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373010954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373010955 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373010956 putative substrate translocation pore; other site 320373010957 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 320373010958 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 320373010959 metal binding site [ion binding]; metal-binding site 320373010960 putative dimer interface [polypeptide binding]; other site 320373010961 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 320373010962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373010963 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373010964 dimerization interface [polypeptide binding]; other site 320373010965 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 320373010966 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 320373010967 putative di-iron ligands [ion binding]; other site 320373010968 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 320373010969 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373010970 substrate binding pocket [chemical binding]; other site 320373010971 membrane-bound complex binding site; other site 320373010972 hinge residues; other site 320373010973 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 320373010974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320373010975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373010976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373010977 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373010978 dimerization interface [polypeptide binding]; other site 320373010979 short chain dehydrogenase; Provisional; Region: PRK07023 320373010980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373010981 NAD(P) binding site [chemical binding]; other site 320373010982 active site 320373010983 SnoaL-like domain; Region: SnoaL_2; pfam12680 320373010984 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 320373010985 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 320373010986 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 320373010987 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 320373010988 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 320373010989 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 320373010990 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320373010991 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320373010992 substrate binding pocket [chemical binding]; other site 320373010993 active site 320373010994 iron coordination sites [ion binding]; other site 320373010995 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 320373010996 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 320373010997 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 320373010998 active site 320373010999 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 320373011000 dimer interface [polypeptide binding]; other site 320373011001 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 320373011002 Ligand Binding Site [chemical binding]; other site 320373011003 Molecular Tunnel; other site 320373011004 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 320373011005 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 320373011006 NADP binding site [chemical binding]; other site 320373011007 dimer interface [polypeptide binding]; other site 320373011008 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 320373011009 putative active site [active] 320373011010 putative metal binding site [ion binding]; other site 320373011011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373011012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011013 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373011014 putative effector binding pocket; other site 320373011015 dimerization interface [polypeptide binding]; other site 320373011016 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 320373011017 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320373011018 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320373011019 hypothetical protein; Provisional; Region: PRK08126 320373011020 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 320373011021 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373011022 ligand binding site [chemical binding]; other site 320373011023 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 320373011024 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320373011025 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 320373011026 Protein of unknown function (DUF796); Region: DUF796; pfam05638 320373011027 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 320373011028 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320373011029 Protein of unknown function (DUF770); Region: DUF770; pfam05591 320373011030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373011031 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320373011032 Walker A motif; other site 320373011033 ATP binding site [chemical binding]; other site 320373011034 Walker B motif; other site 320373011035 arginine finger; other site 320373011036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373011037 Walker A motif; other site 320373011038 ATP binding site [chemical binding]; other site 320373011039 Walker B motif; other site 320373011040 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320373011041 ImpE protein; Region: ImpE; pfam07024 320373011042 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 320373011043 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320373011044 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 320373011045 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 320373011046 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 320373011047 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320373011048 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320373011049 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373011050 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373011051 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 320373011052 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373011053 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373011054 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320373011055 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373011056 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373011057 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373011058 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320373011059 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373011060 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373011061 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 320373011062 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 320373011063 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 320373011064 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373011065 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011066 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 320373011067 putative substrate binding pocket [chemical binding]; other site 320373011068 putative dimerization interface [polypeptide binding]; other site 320373011069 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 320373011070 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320373011071 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373011072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373011073 catalytic residue [active] 320373011074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373011075 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 320373011076 dimer interface [polypeptide binding]; other site 320373011077 putative metal binding site [ion binding]; other site 320373011078 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 320373011079 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 320373011080 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 320373011081 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 320373011082 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320373011083 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320373011084 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 320373011085 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 320373011086 carboxyltransferase (CT) interaction site; other site 320373011087 biotinylation site [posttranslational modification]; other site 320373011088 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 320373011089 putative active site [active] 320373011090 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373011091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011092 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 320373011093 putative substrate binding pocket [chemical binding]; other site 320373011094 dimerization interface [polypeptide binding]; other site 320373011095 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 320373011096 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 320373011097 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 320373011098 active site 320373011099 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 320373011100 TAP-like protein; Region: Abhydrolase_4; pfam08386 320373011101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373011102 S-adenosylmethionine binding site [chemical binding]; other site 320373011103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373011104 dimerization interface [polypeptide binding]; other site 320373011105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373011106 dimer interface [polypeptide binding]; other site 320373011107 putative CheW interface [polypeptide binding]; other site 320373011108 Propionate catabolism activator; Region: PrpR_N; pfam06506 320373011109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373011110 putative active site [active] 320373011111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373011112 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 320373011113 Walker A motif; other site 320373011114 ATP binding site [chemical binding]; other site 320373011115 Walker B motif; other site 320373011116 arginine finger; other site 320373011117 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 320373011118 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 320373011119 tetramer interface [polypeptide binding]; other site 320373011120 active site 320373011121 Mg2+/Mn2+ binding site [ion binding]; other site 320373011122 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 320373011123 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 320373011124 dimer interface [polypeptide binding]; other site 320373011125 active site 320373011126 citrylCoA binding site [chemical binding]; other site 320373011127 oxalacetate/citrate binding site [chemical binding]; other site 320373011128 coenzyme A binding site [chemical binding]; other site 320373011129 catalytic triad [active] 320373011130 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 320373011131 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 320373011132 substrate binding site [chemical binding]; other site 320373011133 ligand binding site [chemical binding]; other site 320373011134 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 320373011135 substrate binding site [chemical binding]; other site 320373011136 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 320373011137 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320373011138 CoenzymeA binding site [chemical binding]; other site 320373011139 subunit interaction site [polypeptide binding]; other site 320373011140 PHB binding site; other site 320373011141 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 320373011142 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 320373011143 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 320373011144 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 320373011145 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 320373011146 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 320373011147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373011148 FeS/SAM binding site; other site 320373011149 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 320373011150 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 320373011151 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 320373011152 dimer interface [polypeptide binding]; other site 320373011153 ligand binding site [chemical binding]; other site 320373011154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373011155 dimer interface [polypeptide binding]; other site 320373011156 putative CheW interface [polypeptide binding]; other site 320373011157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373011158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011159 putative substrate translocation pore; other site 320373011160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011161 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 320373011162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011163 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 320373011164 dimerization interface [polypeptide binding]; other site 320373011165 substrate binding pocket [chemical binding]; other site 320373011166 dimerization interface [polypeptide binding]; other site 320373011167 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 320373011168 putative active cleft [active] 320373011169 MgtC family; Region: MgtC; pfam02308 320373011170 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 320373011171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373011172 Coenzyme A binding pocket [chemical binding]; other site 320373011173 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 320373011174 Heavy-metal-associated domain; Region: HMA; pfam00403 320373011175 metal-binding site [ion binding] 320373011176 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 320373011177 metal-binding site [ion binding] 320373011178 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 320373011179 metal-binding site [ion binding] 320373011180 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 320373011181 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 320373011182 metal-binding site [ion binding] 320373011183 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320373011184 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 320373011185 Uncharacterized conserved protein [Function unknown]; Region: COG5361 320373011186 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 320373011187 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 320373011188 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 320373011189 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 320373011190 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 320373011191 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 320373011192 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 320373011193 Sulfatase; Region: Sulfatase; cl17466 320373011194 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373011195 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 320373011196 active site 320373011197 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 320373011198 active site lid residues [active] 320373011199 substrate binding pocket [chemical binding]; other site 320373011200 catalytic residues [active] 320373011201 substrate-Mg2+ binding site; other site 320373011202 aspartate-rich region 1; other site 320373011203 aspartate-rich region 2; other site 320373011204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373011205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011206 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 320373011207 putative effector binding pocket; other site 320373011208 dimerization interface [polypeptide binding]; other site 320373011209 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320373011210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011211 putative substrate translocation pore; other site 320373011212 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320373011213 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 320373011214 active site 320373011215 catalytic tetrad [active] 320373011216 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320373011217 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 320373011218 FMN binding site [chemical binding]; other site 320373011219 active site 320373011220 substrate binding site [chemical binding]; other site 320373011221 catalytic residue [active] 320373011222 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 320373011223 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 320373011224 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 320373011225 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 320373011226 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 320373011227 tetramer interface [polypeptide binding]; other site 320373011228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373011229 catalytic residue [active] 320373011230 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 320373011231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011232 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 320373011233 putative dimerization interface [polypeptide binding]; other site 320373011234 Transglycosylase; Region: Transgly; pfam00912 320373011235 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 320373011236 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320373011237 Predicted membrane protein [Function unknown]; Region: COG2860 320373011238 UPF0126 domain; Region: UPF0126; pfam03458 320373011239 UPF0126 domain; Region: UPF0126; pfam03458 320373011240 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 320373011241 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 320373011242 Walker A/P-loop; other site 320373011243 ATP binding site [chemical binding]; other site 320373011244 Q-loop/lid; other site 320373011245 ABC transporter signature motif; other site 320373011246 Walker B; other site 320373011247 D-loop; other site 320373011248 H-loop/switch region; other site 320373011249 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 320373011250 putative PBP binding regions; other site 320373011251 ABC-ATPase subunit interface; other site 320373011252 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 320373011253 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 320373011254 intersubunit interface [polypeptide binding]; other site 320373011255 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 320373011256 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 320373011257 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 320373011258 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 320373011259 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373011260 N-terminal plug; other site 320373011261 ligand-binding site [chemical binding]; other site 320373011262 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320373011263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011264 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373011265 dimerization interface [polypeptide binding]; other site 320373011266 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 320373011267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373011268 dimer interface [polypeptide binding]; other site 320373011269 conserved gate region; other site 320373011270 putative PBP binding loops; other site 320373011271 ABC-ATPase subunit interface; other site 320373011272 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 320373011273 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 320373011274 Walker A/P-loop; other site 320373011275 ATP binding site [chemical binding]; other site 320373011276 Q-loop/lid; other site 320373011277 ABC transporter signature motif; other site 320373011278 Walker B; other site 320373011279 D-loop; other site 320373011280 H-loop/switch region; other site 320373011281 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320373011282 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320373011283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373011284 dimer interface [polypeptide binding]; other site 320373011285 conserved gate region; other site 320373011286 putative PBP binding loops; other site 320373011287 ABC-ATPase subunit interface; other site 320373011288 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 320373011289 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 320373011290 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373011291 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373011292 eyelet of channel; other site 320373011293 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 320373011294 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 320373011295 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 320373011296 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 320373011297 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 320373011298 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320373011299 Walker A/P-loop; other site 320373011300 ATP binding site [chemical binding]; other site 320373011301 Q-loop/lid; other site 320373011302 ABC transporter signature motif; other site 320373011303 Walker B; other site 320373011304 D-loop; other site 320373011305 H-loop/switch region; other site 320373011306 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320373011307 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373011308 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373011309 TM-ABC transporter signature motif; other site 320373011310 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 320373011311 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320373011312 putative ligand binding site [chemical binding]; other site 320373011313 short chain dehydrogenase; Provisional; Region: PRK06841 320373011314 classical (c) SDRs; Region: SDR_c; cd05233 320373011315 NAD(P) binding site [chemical binding]; other site 320373011316 active site 320373011317 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 320373011318 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 320373011319 putative NAD(P) binding site [chemical binding]; other site 320373011320 catalytic Zn binding site [ion binding]; other site 320373011321 structural Zn binding site [ion binding]; other site 320373011322 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 320373011323 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 320373011324 DAK2 domain; Region: Dak2; cl03685 320373011325 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 320373011326 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373011327 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373011328 trimer interface [polypeptide binding]; other site 320373011329 eyelet of channel; other site 320373011330 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 320373011331 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 320373011332 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 320373011333 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 320373011334 active site 320373011335 Zn binding site [ion binding]; other site 320373011336 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320373011337 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373011338 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320373011339 substrate binding pocket [chemical binding]; other site 320373011340 membrane-bound complex binding site; other site 320373011341 hinge residues; other site 320373011342 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 320373011343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373011345 dimerization interface [polypeptide binding]; other site 320373011346 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 320373011347 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 320373011348 metal binding site [ion binding]; metal-binding site 320373011349 putative dimer interface [polypeptide binding]; other site 320373011350 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373011351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011352 putative substrate translocation pore; other site 320373011353 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 320373011354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373011355 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 320373011356 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 320373011357 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320373011358 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373011359 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 320373011360 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 320373011361 dimer interface [polypeptide binding]; other site 320373011362 active site 320373011363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373011364 PAS domain; Region: PAS_9; pfam13426 320373011365 putative active site [active] 320373011366 heme pocket [chemical binding]; other site 320373011367 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373011368 dimer interface [polypeptide binding]; other site 320373011369 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 320373011370 putative CheW interface [polypeptide binding]; other site 320373011371 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 320373011372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373011373 S-adenosylmethionine binding site [chemical binding]; other site 320373011374 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 320373011375 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 320373011376 hydrophobic ligand binding site; other site 320373011377 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 320373011378 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320373011379 iron-sulfur cluster [ion binding]; other site 320373011380 [2Fe-2S] cluster binding site [ion binding]; other site 320373011381 succinic semialdehyde dehydrogenase; Region: PLN02278 320373011382 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 320373011383 tetramerization interface [polypeptide binding]; other site 320373011384 NAD(P) binding site [chemical binding]; other site 320373011385 catalytic residues [active] 320373011386 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 320373011387 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373011388 inhibitor-cofactor binding pocket; inhibition site 320373011389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373011390 catalytic residue [active] 320373011391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373011392 DNA-binding site [nucleotide binding]; DNA binding site 320373011393 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373011394 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373011395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373011396 homodimer interface [polypeptide binding]; other site 320373011397 catalytic residue [active] 320373011398 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 320373011399 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 320373011400 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373011401 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373011402 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 320373011403 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 320373011404 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 320373011405 EamA-like transporter family; Region: EamA; cl17759 320373011406 selenophosphate synthetase; Provisional; Region: PRK00943 320373011407 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 320373011408 dimerization interface [polypeptide binding]; other site 320373011409 putative ATP binding site [chemical binding]; other site 320373011410 Purine nucleoside permease (NUP); Region: NUP; pfam06516 320373011411 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320373011412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373011413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011414 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 320373011415 putative effector binding pocket; other site 320373011416 putative dimerization interface [polypeptide binding]; other site 320373011417 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 320373011418 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 320373011419 substrate binding pocket [chemical binding]; other site 320373011420 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 320373011421 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373011422 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373011423 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 320373011424 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373011425 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 320373011426 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 320373011427 Transcriptional regulators [Transcription]; Region: GntR; COG1802 320373011428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373011429 DNA-binding site [nucleotide binding]; DNA binding site 320373011430 FCD domain; Region: FCD; pfam07729 320373011431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373011432 Coenzyme A binding pocket [chemical binding]; other site 320373011433 Membrane transport protein; Region: Mem_trans; cl09117 320373011434 acyl-CoA synthetase; Validated; Region: PRK05850 320373011435 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 320373011436 acyl-activating enzyme (AAE) consensus motif; other site 320373011437 active site 320373011438 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 320373011439 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320373011440 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 320373011441 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373011442 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 320373011443 acyl-activating enzyme (AAE) consensus motif; other site 320373011444 AMP binding site [chemical binding]; other site 320373011445 active site 320373011446 CoA binding site [chemical binding]; other site 320373011447 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 320373011448 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 320373011449 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320373011450 catalytic residue [active] 320373011451 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 320373011452 Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059 320373011453 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 320373011454 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 320373011455 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373011456 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373011457 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320373011458 active site 320373011459 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320373011460 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320373011461 putative NADP binding site [chemical binding]; other site 320373011462 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320373011463 active site 320373011464 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320373011465 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373011466 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373011467 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373011468 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373011469 active site 320373011470 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373011471 Condensation domain; Region: Condensation; pfam00668 320373011472 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373011473 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373011474 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373011475 thioester reductase domain; Region: Thioester-redct; TIGR01746 320373011476 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 320373011477 putative NAD(P) binding site [chemical binding]; other site 320373011478 active site 320373011479 putative substrate binding site [chemical binding]; other site 320373011480 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 320373011481 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 320373011482 tetrameric interface [polypeptide binding]; other site 320373011483 NAD binding site [chemical binding]; other site 320373011484 catalytic residues [active] 320373011485 substrate binding site [chemical binding]; other site 320373011486 hypothetical protein; Provisional; Region: PRK07036 320373011487 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373011488 inhibitor-cofactor binding pocket; inhibition site 320373011489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373011490 catalytic residue [active] 320373011491 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320373011492 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 320373011493 Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508 320373011494 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 320373011495 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373011496 AMP-binding enzyme; Region: AMP-binding; pfam00501 320373011497 acyl-activating enzyme (AAE) consensus motif; other site 320373011498 AMP binding site [chemical binding]; other site 320373011499 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373011500 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320373011501 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373011502 active site 320373011503 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320373011504 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 320373011505 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 320373011506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373011507 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320373011508 NAD(P) binding site [chemical binding]; other site 320373011509 active site 320373011510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373011511 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 320373011512 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320373011513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373011514 DNA binding residues [nucleotide binding] 320373011515 dimerization interface [polypeptide binding]; other site 320373011516 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 320373011517 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 320373011518 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 320373011519 active site 320373011520 non-prolyl cis peptide bond; other site 320373011521 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 320373011522 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 320373011523 Walker A/P-loop; other site 320373011524 ATP binding site [chemical binding]; other site 320373011525 Q-loop/lid; other site 320373011526 ABC transporter signature motif; other site 320373011527 Walker B; other site 320373011528 D-loop; other site 320373011529 H-loop/switch region; other site 320373011530 NIL domain; Region: NIL; pfam09383 320373011531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373011532 dimer interface [polypeptide binding]; other site 320373011533 conserved gate region; other site 320373011534 ABC-ATPase subunit interface; other site 320373011535 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 320373011536 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 320373011537 Flavin binding site [chemical binding]; other site 320373011538 transcriptional regulator NanR; Provisional; Region: PRK03837 320373011539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373011540 DNA-binding site [nucleotide binding]; DNA binding site 320373011541 FCD domain; Region: FCD; pfam07729 320373011542 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 320373011543 Cysteine-rich domain; Region: CCG; pfam02754 320373011544 Cysteine-rich domain; Region: CCG; pfam02754 320373011545 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 320373011546 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 320373011547 4Fe-4S binding domain; Region: Fer4; pfam00037 320373011548 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 320373011549 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 320373011550 glycolate transporter; Provisional; Region: PRK09695 320373011551 L-lactate permease; Region: Lactate_perm; cl00701 320373011552 Predicted membrane protein [Function unknown]; Region: COG2259 320373011553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011554 putative substrate translocation pore; other site 320373011555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011556 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373011557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011558 putative substrate translocation pore; other site 320373011559 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 320373011560 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 320373011561 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 320373011562 dimer interface [polypeptide binding]; other site 320373011563 NADP binding site [chemical binding]; other site 320373011564 catalytic residues [active] 320373011565 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 320373011566 Spore germination protein; Region: Spore_permease; cl17796 320373011567 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 320373011568 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 320373011569 inhibitor site; inhibition site 320373011570 active site 320373011571 dimer interface [polypeptide binding]; other site 320373011572 catalytic residue [active] 320373011573 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 320373011574 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 320373011575 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 320373011576 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 320373011577 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 320373011578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 320373011579 PAS fold; Region: PAS_4; pfam08448 320373011580 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320373011581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373011582 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 320373011583 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 320373011584 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 320373011585 dimer interface [polypeptide binding]; other site 320373011586 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 320373011587 active site 320373011588 Fe binding site [ion binding]; other site 320373011589 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 320373011590 Dehydroquinase class II; Region: DHquinase_II; pfam01220 320373011591 active site 320373011592 trimer interface [polypeptide binding]; other site 320373011593 dimer interface [polypeptide binding]; other site 320373011594 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 320373011595 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 320373011596 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 320373011597 shikimate binding site; other site 320373011598 NAD(P) binding site [chemical binding]; other site 320373011599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011600 D-galactonate transporter; Region: 2A0114; TIGR00893 320373011601 putative substrate translocation pore; other site 320373011602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011603 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 320373011604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373011605 catalytic residue [active] 320373011606 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 320373011607 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320373011608 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 320373011609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373011610 Walker A/P-loop; other site 320373011611 ATP binding site [chemical binding]; other site 320373011612 Q-loop/lid; other site 320373011613 ABC transporter signature motif; other site 320373011614 Walker B; other site 320373011615 D-loop; other site 320373011616 H-loop/switch region; other site 320373011617 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 320373011618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373011619 dimer interface [polypeptide binding]; other site 320373011620 conserved gate region; other site 320373011621 putative PBP binding loops; other site 320373011622 ABC-ATPase subunit interface; other site 320373011623 2-aminoethylphosphonate ABC transport system, membrane component PhnV; Region: PhnV; TIGR03255 320373011624 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 320373011625 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 320373011626 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 320373011627 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 320373011628 NAD(P) binding site [chemical binding]; other site 320373011629 catalytic residues [active] 320373011630 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 320373011631 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 320373011632 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 320373011633 DNA binding residues [nucleotide binding] 320373011634 dimer interface [polypeptide binding]; other site 320373011635 copper binding site [ion binding]; other site 320373011636 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 320373011637 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 320373011638 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320373011639 active site 320373011640 catalytic tetrad [active] 320373011641 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 320373011642 classical (c) SDRs; Region: SDR_c; cd05233 320373011643 NAD(P) binding site [chemical binding]; other site 320373011644 active site 320373011645 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 320373011646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373011647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373011648 homodimer interface [polypeptide binding]; other site 320373011649 catalytic residue [active] 320373011650 excinuclease ABC subunit B; Provisional; Region: PRK05298 320373011651 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 320373011652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320373011653 ATP-binding site [chemical binding]; other site 320373011654 ATP binding site [chemical binding]; other site 320373011655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373011656 nucleotide binding region [chemical binding]; other site 320373011657 ATP-binding site [chemical binding]; other site 320373011658 Ultra-violet resistance protein B; Region: UvrB; pfam12344 320373011659 UvrB/uvrC motif; Region: UVR; pfam02151 320373011660 Fe2+ transport protein; Region: Iron_transport; pfam10634 320373011661 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 320373011662 Iron permease FTR1 family; Region: FTR1; cl00475 320373011663 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 320373011664 4Fe-4S binding domain; Region: Fer4_5; pfam12801 320373011665 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 320373011666 Hemin uptake protein hemP; Region: hemP; pfam10636 320373011667 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 320373011668 putative hydrophobic ligand binding site [chemical binding]; other site 320373011669 Pirin-related protein [General function prediction only]; Region: COG1741 320373011670 Pirin; Region: Pirin; pfam02678 320373011671 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 320373011672 LysR family transcriptional regulator; Provisional; Region: PRK14997 320373011673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011674 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 320373011675 putative effector binding pocket; other site 320373011676 putative dimerization interface [polypeptide binding]; other site 320373011677 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 320373011678 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 320373011679 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 320373011680 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 320373011681 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 320373011682 glutamate racemase; Provisional; Region: PRK00865 320373011683 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 320373011684 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 320373011685 heme binding site [chemical binding]; other site 320373011686 ferroxidase pore; other site 320373011687 ferroxidase diiron center [ion binding]; other site 320373011688 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 320373011689 Fumarase C-terminus; Region: Fumerase_C; pfam05683 320373011690 hypothetical protein; Provisional; Region: PRK05208 320373011691 EamA-like transporter family; Region: EamA; pfam00892 320373011692 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 320373011693 EamA-like transporter family; Region: EamA; pfam00892 320373011694 acetyl-CoA synthetase; Provisional; Region: PRK00174 320373011695 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 320373011696 active site 320373011697 CoA binding site [chemical binding]; other site 320373011698 acyl-activating enzyme (AAE) consensus motif; other site 320373011699 AMP binding site [chemical binding]; other site 320373011700 acetate binding site [chemical binding]; other site 320373011701 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 320373011702 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 320373011703 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 320373011704 Transposase; Region: HTH_Tnp_1; pfam01527 320373011705 HTH-like domain; Region: HTH_21; pfam13276 320373011706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320373011707 Integrase core domain; Region: rve; pfam00665 320373011708 Integrase core domain; Region: rve_3; pfam13683 320373011709 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 320373011710 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373011711 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373011712 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 320373011713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 320373011714 PAAR motif; Region: PAAR_motif; pfam05488 320373011715 HTH-like domain; Region: HTH_21; pfam13276 320373011716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 320373011717 Integrase core domain; Region: rve; pfam00665 320373011718 Integrase core domain; Region: rve_3; pfam13683 320373011719 Transposase; Region: HTH_Tnp_1; pfam01527 320373011720 Transposase; Region: DEDD_Tnp_IS110; pfam01548 320373011721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 320373011722 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 320373011723 Transposase; Region: HTH_Tnp_1; pfam01527 320373011724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 320373011725 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 320373011726 Integrase core domain; Region: rve_3; pfam13683 320373011727 putative transposase OrfB; Reviewed; Region: PHA02517 320373011728 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320373011729 Bacterial Ig-like domain; Region: Big_5; pfam13205 320373011730 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 320373011731 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373011732 PYR/PP interface [polypeptide binding]; other site 320373011733 dimer interface [polypeptide binding]; other site 320373011734 TPP binding site [chemical binding]; other site 320373011735 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373011736 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 320373011737 TPP-binding site [chemical binding]; other site 320373011738 dimer interface [polypeptide binding]; other site 320373011739 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 320373011740 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 320373011741 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 320373011742 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 320373011743 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 320373011744 SLBB domain; Region: SLBB; pfam10531 320373011745 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 320373011746 Chain length determinant protein; Region: Wzz; pfam02706 320373011747 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 320373011748 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 320373011749 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 320373011750 substrate binding site; other site 320373011751 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 320373011752 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 320373011753 NAD binding site [chemical binding]; other site 320373011754 homotetramer interface [polypeptide binding]; other site 320373011755 homodimer interface [polypeptide binding]; other site 320373011756 substrate binding site [chemical binding]; other site 320373011757 active site 320373011758 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 320373011759 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 320373011760 inhibitor-cofactor binding pocket; inhibition site 320373011761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373011762 catalytic residue [active] 320373011763 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 320373011764 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320373011765 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 320373011766 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 320373011767 inhibitor-cofactor binding pocket; inhibition site 320373011768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373011769 catalytic residue [active] 320373011770 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 320373011771 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 320373011772 active site 320373011773 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320373011774 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373011775 putative active site [active] 320373011776 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320373011777 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373011778 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373011779 putative active site [active] 320373011780 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 320373011781 trimer interface [polypeptide binding]; other site 320373011782 active site 320373011783 substrate binding site [chemical binding]; other site 320373011784 CoA binding site [chemical binding]; other site 320373011785 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 320373011786 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 320373011787 active site 320373011788 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 320373011789 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373011790 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011791 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373011792 putative effector binding pocket; other site 320373011793 dimerization interface [polypeptide binding]; other site 320373011794 Pirin-related protein [General function prediction only]; Region: COG1741 320373011795 Pirin; Region: Pirin; pfam02678 320373011796 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 320373011797 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320373011798 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320373011799 ligand binding site [chemical binding]; other site 320373011800 flexible hinge region; other site 320373011801 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320373011802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373011803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373011804 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373011805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373011806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373011807 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 320373011808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373011809 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 320373011810 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373011811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373011812 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373011813 putative effector binding pocket; other site 320373011814 dimerization interface [polypeptide binding]; other site 320373011815 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 320373011816 Isochorismatase family; Region: Isochorismatase; pfam00857 320373011817 catalytic triad [active] 320373011818 dimer interface [polypeptide binding]; other site 320373011819 conserved cis-peptide bond; other site 320373011820 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 320373011821 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 320373011822 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 320373011823 active site 320373011824 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 320373011825 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373011826 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373011827 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 320373011828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373011829 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373011830 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 320373011831 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 320373011832 NAD binding site [chemical binding]; other site 320373011833 active site 320373011834 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 320373011835 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373011836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373011837 DNA-binding site [nucleotide binding]; DNA binding site 320373011838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373011839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373011840 homodimer interface [polypeptide binding]; other site 320373011841 catalytic residue [active] 320373011842 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 320373011843 Putative amidotransferase; Region: DUF4066; pfam13278 320373011844 conserved cys residue [active] 320373011845 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320373011846 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 320373011847 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 320373011848 hypothetical protein; Provisional; Region: PRK08609 320373011849 active site 320373011850 primer binding site [nucleotide binding]; other site 320373011851 NTP binding site [chemical binding]; other site 320373011852 metal binding triad [ion binding]; metal-binding site 320373011853 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 320373011854 active site 320373011855 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 320373011856 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 320373011857 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 320373011858 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 320373011859 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 320373011860 CopC domain; Region: CopC; pfam04234 320373011861 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320373011862 HAMP domain; Region: HAMP; pfam00672 320373011863 dimerization interface [polypeptide binding]; other site 320373011864 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320373011865 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373011866 dimer interface [polypeptide binding]; other site 320373011867 putative CheW interface [polypeptide binding]; other site 320373011868 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 320373011869 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 320373011870 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 320373011871 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 320373011872 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 320373011873 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 320373011874 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 320373011875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373011876 dimer interface [polypeptide binding]; other site 320373011877 conserved gate region; other site 320373011878 putative PBP binding loops; other site 320373011879 ABC-ATPase subunit interface; other site 320373011880 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 320373011881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373011882 dimer interface [polypeptide binding]; other site 320373011883 conserved gate region; other site 320373011884 putative PBP binding loops; other site 320373011885 ABC-ATPase subunit interface; other site 320373011886 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 320373011887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373011888 Walker A/P-loop; other site 320373011889 ATP binding site [chemical binding]; other site 320373011890 Q-loop/lid; other site 320373011891 ABC transporter signature motif; other site 320373011892 Walker B; other site 320373011893 D-loop; other site 320373011894 H-loop/switch region; other site 320373011895 TOBE domain; Region: TOBE_2; pfam08402 320373011896 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 320373011897 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320373011898 putative aminotransferase; Validated; Region: PRK07480 320373011899 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373011900 inhibitor-cofactor binding pocket; inhibition site 320373011901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373011902 catalytic residue [active] 320373011903 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 320373011904 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 320373011905 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 320373011906 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 320373011907 catalytic triad [active] 320373011908 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 320373011909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373011910 non-specific DNA binding site [nucleotide binding]; other site 320373011911 salt bridge; other site 320373011912 sequence-specific DNA binding site [nucleotide binding]; other site 320373011913 Cupin domain; Region: Cupin_2; pfam07883 320373011914 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 320373011915 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 320373011916 NAD(P) binding site [chemical binding]; other site 320373011917 catalytic residues [active] 320373011918 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 320373011919 agmatinase; Region: agmatinase; TIGR01230 320373011920 oligomer interface [polypeptide binding]; other site 320373011921 putative active site [active] 320373011922 Mn binding site [ion binding]; other site 320373011923 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 320373011924 oligomerisation interface [polypeptide binding]; other site 320373011925 mobile loop; other site 320373011926 roof hairpin; other site 320373011927 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 320373011928 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 320373011929 ring oligomerisation interface [polypeptide binding]; other site 320373011930 ATP/Mg binding site [chemical binding]; other site 320373011931 stacking interactions; other site 320373011932 hinge regions; other site 320373011933 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 320373011934 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 320373011935 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 320373011936 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 320373011937 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 320373011938 active site 320373011939 dimer interface [polypeptide binding]; other site 320373011940 effector binding site; other site 320373011941 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373011942 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 320373011943 acyl-activating enzyme (AAE) consensus motif; other site 320373011944 AMP binding site [chemical binding]; other site 320373011945 active site 320373011946 CoA binding site [chemical binding]; other site 320373011947 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 320373011948 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320373011949 active site 320373011950 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 320373011951 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 320373011952 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 320373011953 dimer interface [polypeptide binding]; other site 320373011954 active site 320373011955 CoA binding pocket [chemical binding]; other site 320373011956 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320373011957 acyl-CoA synthetase; Validated; Region: PRK05850 320373011958 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 320373011959 acyl-activating enzyme (AAE) consensus motif; other site 320373011960 active site 320373011961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373011962 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 320373011963 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 320373011964 active site 320373011965 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373011966 MAPEG family; Region: MAPEG; cl09190 320373011967 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 320373011968 putative hydrophobic ligand binding site [chemical binding]; other site 320373011969 Integrase core domain; Region: rve_3; pfam13683 320373011970 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 320373011971 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 320373011972 catalytic residue [active] 320373011973 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 320373011974 catalytic residues [active] 320373011975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373011976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373011977 peroxiredoxin; Region: AhpC; TIGR03137 320373011978 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 320373011979 dimer interface [polypeptide binding]; other site 320373011980 decamer (pentamer of dimers) interface [polypeptide binding]; other site 320373011981 catalytic triad [active] 320373011982 peroxidatic and resolving cysteines [active] 320373011983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 320373011984 Chitin binding domain; Region: Chitin_bind_3; pfam03067 320373011985 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 320373011986 putative FMN binding site [chemical binding]; other site 320373011987 Uncharacterized conserved protein [Function unknown]; Region: COG2308 320373011988 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 320373011989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 320373011990 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 320373011991 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 320373011992 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 320373011993 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 320373011994 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 320373011995 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 320373011996 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 320373011997 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 320373011998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 320373011999 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 320373012000 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 320373012001 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 320373012002 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 320373012003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373012004 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373012005 DNA-binding site [nucleotide binding]; DNA binding site 320373012006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373012007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373012008 homodimer interface [polypeptide binding]; other site 320373012009 catalytic residue [active] 320373012010 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 320373012011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373012012 putative substrate translocation pore; other site 320373012013 Predicted membrane protein [Function unknown]; Region: COG1289 320373012014 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 320373012015 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320373012016 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 320373012017 conserved cys residue [active] 320373012018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373012019 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 320373012020 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 320373012021 conserved cys residue [active] 320373012022 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373012023 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373012024 catalytic residue [active] 320373012025 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373012026 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 320373012027 PYR/PP interface [polypeptide binding]; other site 320373012028 dimer interface [polypeptide binding]; other site 320373012029 TPP binding site [chemical binding]; other site 320373012030 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 320373012031 TPP-binding site [chemical binding]; other site 320373012032 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 320373012033 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 320373012034 tetramer interface [polypeptide binding]; other site 320373012035 active site 320373012036 Mg2+/Mn2+ binding site [ion binding]; other site 320373012037 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 320373012038 active site 320373012039 metal-binding site 320373012040 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 320373012041 active site 320373012042 metal-binding site 320373012043 putative membrane protein; Region: HpnL; TIGR03476 320373012044 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 320373012045 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 320373012046 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 320373012047 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 320373012048 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 320373012049 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320373012050 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 320373012051 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 320373012052 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 320373012053 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320373012054 Protein of unknown function (DUF796); Region: DUF796; pfam05638 320373012055 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 320373012056 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320373012057 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 320373012058 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 320373012059 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 320373012060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373012061 Walker A motif; other site 320373012062 ATP binding site [chemical binding]; other site 320373012063 Walker B motif; other site 320373012064 arginine finger; other site 320373012065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 320373012066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373012067 Walker A motif; other site 320373012068 ATP binding site [chemical binding]; other site 320373012069 Walker B motif; other site 320373012070 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 320373012071 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320373012072 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373012073 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373012074 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320373012075 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373012076 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373012077 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 320373012078 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320373012079 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320373012080 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320373012081 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320373012082 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373012083 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 320373012084 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 320373012085 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 320373012086 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 320373012087 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320373012088 hypothetical protein; Provisional; Region: PRK14693 320373012089 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 320373012090 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373012091 ligand binding site [chemical binding]; other site 320373012092 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 320373012093 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320373012094 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320373012095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320373012096 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 320373012097 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 320373012098 active site 320373012099 TDP-binding site; other site 320373012100 acceptor substrate-binding pocket; other site 320373012101 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320373012102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373012103 putative substrate translocation pore; other site 320373012104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373012105 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 320373012106 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 320373012107 Ligand binding site; other site 320373012108 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373012109 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 320373012110 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373012111 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373012112 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 320373012113 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 320373012114 substrate binding [chemical binding]; other site 320373012115 active site 320373012116 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 320373012117 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 320373012118 active site 320373012119 Transcriptional regulators [Transcription]; Region: PurR; COG1609 320373012120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 320373012121 DNA binding site [nucleotide binding] 320373012122 domain linker motif; other site 320373012123 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 320373012124 ligand binding site [chemical binding]; other site 320373012125 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 320373012126 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 320373012127 NAD binding site [chemical binding]; other site 320373012128 catalytic Zn binding site [ion binding]; other site 320373012129 structural Zn binding site [ion binding]; other site 320373012130 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320373012131 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 320373012132 conserved cys residue [active] 320373012133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373012134 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 320373012135 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 320373012136 dimer interface [polypeptide binding]; other site 320373012137 active site 320373012138 glycine-pyridoxal phosphate binding site [chemical binding]; other site 320373012139 folate binding site [chemical binding]; other site 320373012140 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 320373012141 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 320373012142 active site 320373012143 dimer interface [polypeptide binding]; other site 320373012144 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 320373012145 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 320373012146 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 320373012147 putative active site [active] 320373012148 putative FMN binding site [chemical binding]; other site 320373012149 putative substrate binding site [chemical binding]; other site 320373012150 putative catalytic residue [active] 320373012151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320373012152 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 320373012153 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 320373012154 Cysteine-rich domain; Region: CCG; pfam02754 320373012155 Cysteine-rich domain; Region: CCG; pfam02754 320373012156 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 320373012157 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 320373012158 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 320373012159 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320373012160 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320373012161 [2Fe-2S] cluster binding site [ion binding]; other site 320373012162 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 320373012163 putative alpha subunit interface [polypeptide binding]; other site 320373012164 putative active site [active] 320373012165 putative substrate binding site [chemical binding]; other site 320373012166 Fe binding site [ion binding]; other site 320373012167 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 320373012168 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 320373012169 FAD binding pocket [chemical binding]; other site 320373012170 FAD binding motif [chemical binding]; other site 320373012171 phosphate binding motif [ion binding]; other site 320373012172 beta-alpha-beta structure motif; other site 320373012173 NAD binding pocket [chemical binding]; other site 320373012174 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 320373012175 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373012176 catalytic loop [active] 320373012177 iron binding site [ion binding]; other site 320373012178 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 320373012179 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 320373012180 Amino acid permease; Region: AA_permease_2; pfam13520 320373012181 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 320373012182 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 320373012183 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 320373012184 putative active site [active] 320373012185 putative substrate binding site [chemical binding]; other site 320373012186 putative cosubstrate binding site; other site 320373012187 catalytic site [active] 320373012188 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 320373012189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373012190 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320373012191 substrate binding pocket [chemical binding]; other site 320373012192 dimerization interface [polypeptide binding]; other site 320373012193 choline-sulfatase; Region: chol_sulfatase; TIGR03417 320373012194 Sulfatase; Region: Sulfatase; cl17466 320373012195 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 320373012196 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 320373012197 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 320373012198 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373012199 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373012200 trimer interface [polypeptide binding]; other site 320373012201 eyelet of channel; other site 320373012202 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 320373012203 Peptidase family M28; Region: Peptidase_M28; pfam04389 320373012204 active site 320373012205 metal binding site [ion binding]; metal-binding site 320373012206 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 320373012207 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 320373012208 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 320373012209 Zn binding site [ion binding]; other site 320373012210 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320373012211 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 320373012212 conserved cys residue [active] 320373012213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373012214 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 320373012215 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 320373012216 Uncharacterized conserved protein [Function unknown]; Region: COG3246 320373012217 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 320373012218 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 320373012219 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 320373012220 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 320373012221 active site 320373012222 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 320373012223 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320373012224 short chain dehydrogenase; Provisional; Region: PRK06197 320373012225 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 320373012226 putative NAD(P) binding site [chemical binding]; other site 320373012227 active site 320373012228 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 320373012229 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 320373012230 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320373012231 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320373012232 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320373012233 dimerization interface [polypeptide binding]; other site 320373012234 ligand binding site [chemical binding]; other site 320373012235 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373012236 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 320373012237 TM-ABC transporter signature motif; other site 320373012238 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 320373012239 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 320373012240 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 320373012241 TM-ABC transporter signature motif; other site 320373012242 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 320373012243 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 320373012244 Walker A/P-loop; other site 320373012245 ATP binding site [chemical binding]; other site 320373012246 Q-loop/lid; other site 320373012247 ABC transporter signature motif; other site 320373012248 Walker B; other site 320373012249 D-loop; other site 320373012250 H-loop/switch region; other site 320373012251 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 320373012252 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 320373012253 Walker A/P-loop; other site 320373012254 ATP binding site [chemical binding]; other site 320373012255 Q-loop/lid; other site 320373012256 ABC transporter signature motif; other site 320373012257 Walker B; other site 320373012258 D-loop; other site 320373012259 H-loop/switch region; other site 320373012260 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 320373012261 Peptidase family M23; Region: Peptidase_M23; pfam01551 320373012262 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 320373012263 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 320373012264 chorismate binding enzyme; Region: Chorismate_bind; cl10555 320373012265 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 320373012266 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 320373012267 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 320373012268 nucleophilic elbow; other site 320373012269 catalytic triad; other site 320373012270 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 320373012271 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 320373012272 acyl-activating enzyme (AAE) consensus motif; other site 320373012273 active site 320373012274 AMP binding site [chemical binding]; other site 320373012275 substrate binding site [chemical binding]; other site 320373012276 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320373012277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373012278 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 320373012279 Condensation domain; Region: Condensation; pfam00668 320373012280 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373012281 Nonribosomal peptide synthase; Region: NRPS; pfam08415 320373012282 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 320373012283 acyl-activating enzyme (AAE) consensus motif; other site 320373012284 AMP binding site [chemical binding]; other site 320373012285 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320373012286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373012287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373012288 Condensation domain; Region: Condensation; pfam00668 320373012289 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373012290 Nonribosomal peptide synthase; Region: NRPS; pfam08415 320373012291 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 320373012292 acyl-activating enzyme (AAE) consensus motif; other site 320373012293 AMP binding site [chemical binding]; other site 320373012294 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320373012295 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373012296 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 320373012297 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 320373012298 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 320373012299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373012300 Walker A/P-loop; other site 320373012301 ATP binding site [chemical binding]; other site 320373012302 Q-loop/lid; other site 320373012303 ABC transporter signature motif; other site 320373012304 Walker B; other site 320373012305 D-loop; other site 320373012306 H-loop/switch region; other site 320373012307 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 320373012308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373012309 Walker A/P-loop; other site 320373012310 ATP binding site [chemical binding]; other site 320373012311 Q-loop/lid; other site 320373012312 ABC transporter signature motif; other site 320373012313 Walker B; other site 320373012314 D-loop; other site 320373012315 H-loop/switch region; other site 320373012316 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 320373012317 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373012318 N-terminal plug; other site 320373012319 ligand-binding site [chemical binding]; other site 320373012320 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 320373012321 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 320373012322 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 320373012323 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373012324 catalytic loop [active] 320373012325 iron binding site [ion binding]; other site 320373012326 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 320373012327 GAF domain; Region: GAF; pfam01590 320373012328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373012329 Walker A motif; other site 320373012330 ATP binding site [chemical binding]; other site 320373012331 Walker B motif; other site 320373012332 arginine finger; other site 320373012333 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373012334 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 320373012335 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 320373012336 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 320373012337 TIGR02594 family protein; Region: TIGR02594 320373012338 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 320373012339 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320373012340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373012341 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320373012342 dimerization interface [polypeptide binding]; other site 320373012343 substrate binding pocket [chemical binding]; other site 320373012344 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 320373012345 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 320373012346 NAD(P) binding site [chemical binding]; other site 320373012347 catalytic residues [active] 320373012348 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320373012349 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 320373012350 active site 320373012351 iron coordination sites [ion binding]; other site 320373012352 substrate binding pocket [chemical binding]; other site 320373012353 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373012354 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 320373012355 PYR/PP interface [polypeptide binding]; other site 320373012356 dimer interface [polypeptide binding]; other site 320373012357 TPP binding site [chemical binding]; other site 320373012358 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 320373012359 TPP-binding site; other site 320373012360 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 320373012361 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 320373012362 tetramer interface [polypeptide binding]; other site 320373012363 active site 320373012364 Mg2+/Mn2+ binding site [ion binding]; other site 320373012365 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 320373012366 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 320373012367 short chain dehydrogenase; Validated; Region: PRK05855 320373012368 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373012369 classical (c) SDRs; Region: SDR_c; cd05233 320373012370 NAD(P) binding site [chemical binding]; other site 320373012371 active site 320373012372 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 320373012373 active site 320373012374 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 320373012375 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 320373012376 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 320373012377 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 320373012378 active site 320373012379 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 320373012380 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 320373012381 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373012382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373012383 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373012384 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373012385 active site 320373012386 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 320373012387 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 320373012388 active site 320373012389 acyl-activating enzyme (AAE) consensus motif; other site 320373012390 putative CoA binding site [chemical binding]; other site 320373012391 AMP binding site [chemical binding]; other site 320373012392 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 320373012393 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 320373012394 tetrameric interface [polypeptide binding]; other site 320373012395 NAD binding site [chemical binding]; other site 320373012396 catalytic residues [active] 320373012397 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 320373012398 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 320373012399 enoyl-CoA hydratase; Provisional; Region: PRK09076 320373012400 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373012401 substrate binding site [chemical binding]; other site 320373012402 oxyanion hole (OAH) forming residues; other site 320373012403 trimer interface [polypeptide binding]; other site 320373012404 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 320373012405 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373012406 substrate binding site [chemical binding]; other site 320373012407 oxyanion hole (OAH) forming residues; other site 320373012408 trimer interface [polypeptide binding]; other site 320373012409 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 320373012410 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373012411 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 320373012412 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320373012413 Walker A/P-loop; other site 320373012414 ATP binding site [chemical binding]; other site 320373012415 Q-loop/lid; other site 320373012416 ABC transporter signature motif; other site 320373012417 Walker B; other site 320373012418 D-loop; other site 320373012419 H-loop/switch region; other site 320373012420 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 320373012421 FtsX-like permease family; Region: FtsX; pfam02687 320373012422 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 320373012423 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373012424 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373012425 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 320373012426 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 320373012427 active site 320373012428 dimer interface [polypeptide binding]; other site 320373012429 non-prolyl cis peptide bond; other site 320373012430 insertion regions; other site 320373012431 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 320373012432 B1 nucleotide binding pocket [chemical binding]; other site 320373012433 B2 nucleotide binding pocket [chemical binding]; other site 320373012434 CAS motifs; other site 320373012435 active site 320373012436 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 320373012437 glutaminase; Provisional; Region: PRK00971 320373012438 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 320373012439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373012440 active site 320373012441 phosphorylation site [posttranslational modification] 320373012442 intermolecular recognition site; other site 320373012443 dimerization interface [polypeptide binding]; other site 320373012444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373012445 DNA binding site [nucleotide binding] 320373012446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373012447 dimer interface [polypeptide binding]; other site 320373012448 phosphorylation site [posttranslational modification] 320373012449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373012450 ATP binding site [chemical binding]; other site 320373012451 Mg2+ binding site [ion binding]; other site 320373012452 G-X-G motif; other site 320373012453 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 320373012454 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 320373012455 active site 320373012456 nucleophile elbow; other site 320373012457 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 320373012458 Surface antigen; Region: Bac_surface_Ag; pfam01103 320373012459 rod shape-determining protein MreB; Provisional; Region: PRK13930 320373012460 MreB and similar proteins; Region: MreB_like; cd10225 320373012461 nucleotide binding site [chemical binding]; other site 320373012462 Mg binding site [ion binding]; other site 320373012463 putative protofilament interaction site [polypeptide binding]; other site 320373012464 RodZ interaction site [polypeptide binding]; other site 320373012465 Cytochrome c; Region: Cytochrom_C; cl11414 320373012466 HD domain; Region: HD_3; pfam13023 320373012467 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 320373012468 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 320373012469 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 320373012470 substrate binding pocket [chemical binding]; other site 320373012471 substrate-Mg2+ binding site; other site 320373012472 aspartate-rich region 1; other site 320373012473 aspartate-rich region 2; other site 320373012474 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 320373012475 putative dimer interface [polypeptide binding]; other site 320373012476 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373012477 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320373012478 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 320373012479 C-terminal domain interface [polypeptide binding]; other site 320373012480 GSH binding site (G-site) [chemical binding]; other site 320373012481 dimer interface [polypeptide binding]; other site 320373012482 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 320373012483 N-terminal domain interface [polypeptide binding]; other site 320373012484 dimer interface [polypeptide binding]; other site 320373012485 substrate binding pocket (H-site) [chemical binding]; other site 320373012486 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 320373012487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373012488 dimer interface [polypeptide binding]; other site 320373012489 phosphorylation site [posttranslational modification] 320373012490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373012491 ATP binding site [chemical binding]; other site 320373012492 Mg2+ binding site [ion binding]; other site 320373012493 G-X-G motif; other site 320373012494 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 320373012495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373012496 active site 320373012497 phosphorylation site [posttranslational modification] 320373012498 intermolecular recognition site; other site 320373012499 dimerization interface [polypeptide binding]; other site 320373012500 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373012501 DNA binding site [nucleotide binding] 320373012502 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320373012503 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320373012504 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320373012505 putative active site [active] 320373012506 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 320373012507 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 320373012508 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 320373012509 active site residue [active] 320373012510 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 320373012511 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 320373012512 conserved cys residue [active] 320373012513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373012514 hypothetical protein; Provisional; Region: PRK07907 320373012515 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 320373012516 metal binding site [ion binding]; metal-binding site 320373012517 putative dimer interface [polypeptide binding]; other site 320373012518 TfoX N-terminal domain; Region: TfoX_N; pfam04993 320373012519 NnrU protein; Region: NnrU; pfam07298 320373012520 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 320373012521 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 320373012522 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 320373012523 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 320373012524 VirK protein; Region: VirK; pfam06903 320373012525 HTH-like domain; Region: HTH_21; pfam13276 320373012526 Integrase core domain; Region: rve; pfam00665 320373012527 Integrase core domain; Region: rve_3; cl15866 320373012528 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 320373012529 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 320373012530 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 320373012531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 320373012532 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 320373012533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373012534 putative substrate translocation pore; other site 320373012535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373012536 Trehalase; Region: Trehalase; cl17346 320373012537 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 320373012538 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 320373012539 Subunit I/III interface [polypeptide binding]; other site 320373012540 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320373012541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373012542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373012543 DNA binding residues [nucleotide binding] 320373012544 dimerization interface [polypeptide binding]; other site 320373012545 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320373012546 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 320373012547 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 320373012548 active site 320373012549 dimer interface [polypeptide binding]; other site 320373012550 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 320373012551 Ligand Binding Site [chemical binding]; other site 320373012552 Molecular Tunnel; other site 320373012553 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 320373012554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373012555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373012556 DNA binding site [nucleotide binding] 320373012557 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 320373012558 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 320373012559 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 320373012560 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 320373012561 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 320373012562 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 320373012563 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373012564 catalytic loop [active] 320373012565 iron binding site [ion binding]; other site 320373012566 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 320373012567 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 320373012568 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320373012569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373012570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373012571 SnoaL-like domain; Region: SnoaL_2; pfam12680 320373012572 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 320373012573 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 320373012574 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 320373012575 Flavin binding site [chemical binding]; other site 320373012576 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 320373012577 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373012578 active site 320373012579 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 320373012580 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 320373012581 active site 320373012582 non-prolyl cis peptide bond; other site 320373012583 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373012584 dimerization interface [polypeptide binding]; other site 320373012585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373012586 dimer interface [polypeptide binding]; other site 320373012587 phosphorylation site [posttranslational modification] 320373012588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373012589 ATP binding site [chemical binding]; other site 320373012590 Mg2+ binding site [ion binding]; other site 320373012591 G-X-G motif; other site 320373012592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373012593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373012594 active site 320373012595 phosphorylation site [posttranslational modification] 320373012596 intermolecular recognition site; other site 320373012597 dimerization interface [polypeptide binding]; other site 320373012598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373012599 DNA binding site [nucleotide binding] 320373012600 MltA-interacting protein MipA; Region: MipA; cl01504 320373012601 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320373012602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373012603 NAD(P) binding site [chemical binding]; other site 320373012604 active site 320373012605 MarR family; Region: MarR_2; cl17246 320373012606 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320373012607 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 320373012608 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 320373012609 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 320373012610 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 320373012611 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 320373012612 NAD binding site [chemical binding]; other site 320373012613 catalytic residues [active] 320373012614 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 320373012615 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 320373012616 putative active site [active] 320373012617 putative metal binding site [ion binding]; other site 320373012618 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 320373012619 putative substrate binding pocket [chemical binding]; other site 320373012620 trimer interface [polypeptide binding]; other site 320373012621 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 320373012622 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 320373012623 Helix-turn-helix domain; Region: HTH_18; pfam12833 320373012624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373012625 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 320373012626 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320373012627 NAD(P) binding site [chemical binding]; other site 320373012628 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373012629 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373012630 trimer interface [polypeptide binding]; other site 320373012631 eyelet of channel; other site 320373012632 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 320373012633 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 320373012634 Walker A/P-loop; other site 320373012635 ATP binding site [chemical binding]; other site 320373012636 Q-loop/lid; other site 320373012637 ABC transporter signature motif; other site 320373012638 Walker B; other site 320373012639 D-loop; other site 320373012640 H-loop/switch region; other site 320373012641 TOBE domain; Region: TOBE_2; pfam08402 320373012642 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 320373012643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373012644 dimer interface [polypeptide binding]; other site 320373012645 conserved gate region; other site 320373012646 ABC-ATPase subunit interface; other site 320373012647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373012648 dimer interface [polypeptide binding]; other site 320373012649 conserved gate region; other site 320373012650 putative PBP binding loops; other site 320373012651 ABC-ATPase subunit interface; other site 320373012652 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320373012653 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 320373012654 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 320373012655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373012656 active site 320373012657 phosphorylation site [posttranslational modification] 320373012658 intermolecular recognition site; other site 320373012659 dimerization interface [polypeptide binding]; other site 320373012660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373012661 DNA binding site [nucleotide binding] 320373012662 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 320373012663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373012664 dimer interface [polypeptide binding]; other site 320373012665 phosphorylation site [posttranslational modification] 320373012666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373012667 ATP binding site [chemical binding]; other site 320373012668 Mg2+ binding site [ion binding]; other site 320373012669 G-X-G motif; other site 320373012670 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 320373012671 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 320373012672 MOSC domain; Region: MOSC; pfam03473 320373012673 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373012674 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373012675 trimer interface [polypeptide binding]; other site 320373012676 eyelet of channel; other site 320373012677 enoyl-CoA hydratase; Validated; Region: PRK08139 320373012678 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373012679 substrate binding site [chemical binding]; other site 320373012680 oxyanion hole (OAH) forming residues; other site 320373012681 trimer interface [polypeptide binding]; other site 320373012682 alanine racemase; Reviewed; Region: PRK13340 320373012683 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 320373012684 active site 320373012685 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320373012686 substrate binding site [chemical binding]; other site 320373012687 catalytic residues [active] 320373012688 dimer interface [polypeptide binding]; other site 320373012689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 320373012690 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 320373012691 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 320373012692 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 320373012693 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 320373012694 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 320373012695 Esterase/lipase [General function prediction only]; Region: COG1647 320373012696 MASE1; Region: MASE1; pfam05231 320373012697 PAS fold; Region: PAS_3; pfam08447 320373012698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373012699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373012700 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 320373012701 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 320373012702 potential catalytic triad [active] 320373012703 conserved cys residue [active] 320373012704 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320373012705 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 320373012706 active site 320373012707 FMN binding site [chemical binding]; other site 320373012708 substrate binding site [chemical binding]; other site 320373012709 homotetramer interface [polypeptide binding]; other site 320373012710 catalytic residue [active] 320373012711 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 320373012712 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 320373012713 NAD binding site [chemical binding]; other site 320373012714 homotetramer interface [polypeptide binding]; other site 320373012715 homodimer interface [polypeptide binding]; other site 320373012716 substrate binding site [chemical binding]; other site 320373012717 active site 320373012718 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 320373012719 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 320373012720 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320373012721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373012722 NAD(P) binding site [chemical binding]; other site 320373012723 active site 320373012724 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373012725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373012726 DNA-binding site [nucleotide binding]; DNA binding site 320373012727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373012728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373012729 homodimer interface [polypeptide binding]; other site 320373012730 catalytic residue [active] 320373012731 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 320373012732 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 320373012733 Mg2+ binding site [ion binding]; other site 320373012734 G-X-G motif; other site 320373012735 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 320373012736 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320373012737 ligand binding site [chemical binding]; other site 320373012738 flexible hinge region; other site 320373012739 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 320373012740 acyl-CoA synthetase; Validated; Region: PRK08162 320373012741 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 320373012742 acyl-activating enzyme (AAE) consensus motif; other site 320373012743 putative active site [active] 320373012744 AMP binding site [chemical binding]; other site 320373012745 putative CoA binding site [chemical binding]; other site 320373012746 Cache domain; Region: Cache_1; pfam02743 320373012747 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373012748 dimer interface [polypeptide binding]; other site 320373012749 putative CheW interface [polypeptide binding]; other site 320373012750 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 320373012751 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 320373012752 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 320373012753 DXD motif; other site 320373012754 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373012755 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373012756 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 320373012757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373012758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373012759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373012760 dimerization interface [polypeptide binding]; other site 320373012761 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 320373012762 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373012763 inhibitor-cofactor binding pocket; inhibition site 320373012764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373012765 catalytic residue [active] 320373012766 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 320373012767 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 320373012768 tetrameric interface [polypeptide binding]; other site 320373012769 NAD binding site [chemical binding]; other site 320373012770 catalytic residues [active] 320373012771 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 320373012772 Secretory lipase; Region: LIP; pfam03583 320373012773 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 320373012774 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373012775 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373012776 trimer interface [polypeptide binding]; other site 320373012777 eyelet of channel; other site 320373012778 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 320373012779 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 320373012780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373012781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373012782 DNA binding residues [nucleotide binding] 320373012783 dimerization interface [polypeptide binding]; other site 320373012784 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 320373012785 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 320373012786 homodimer interface [polypeptide binding]; other site 320373012787 homotetramer interface [polypeptide binding]; other site 320373012788 active site pocket [active] 320373012789 cleavage site 320373012790 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 320373012791 Fusaric acid resistance protein family; Region: FUSC; pfam04632 320373012792 transcriptional regulator; Provisional; Region: PRK10632 320373012793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373012794 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373012795 putative effector binding pocket; other site 320373012796 dimerization interface [polypeptide binding]; other site 320373012797 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320373012798 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373012799 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373012800 trimer interface [polypeptide binding]; other site 320373012801 eyelet of channel; other site 320373012802 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 320373012803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373012804 cytosine permease; Provisional; Region: codB; PRK11017 320373012805 Na binding site [ion binding]; other site 320373012806 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 320373012807 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 320373012808 cytosine deaminase; Provisional; Region: PRK09230 320373012809 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 320373012810 active site 320373012811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373012812 putative substrate translocation pore; other site 320373012813 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 320373012814 short chain dehydrogenase; Provisional; Region: PRK12829 320373012815 classical (c) SDRs; Region: SDR_c; cd05233 320373012816 NAD(P) binding site [chemical binding]; other site 320373012817 active site 320373012818 Transcriptional regulators [Transcription]; Region: GntR; COG1802 320373012819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 320373012820 FCD domain; Region: FCD; pfam07729 320373012821 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 320373012822 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 320373012823 putative ion selectivity filter; other site 320373012824 putative pore gating glutamate residue; other site 320373012825 H-type lectin domain; Region: H_lectin; pfam09458 320373012826 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 320373012827 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 320373012828 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373012829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 320373012830 active site 320373012831 phosphorylation site [posttranslational modification] 320373012832 intermolecular recognition site; other site 320373012833 dimerization interface [polypeptide binding]; other site 320373012834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373012835 DNA binding residues [nucleotide binding] 320373012836 dimerization interface [polypeptide binding]; other site 320373012837 MarR family; Region: MarR_2; cl17246 320373012838 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320373012839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373012840 dimerization interface [polypeptide binding]; other site 320373012841 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373012842 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373012843 TM-ABC transporter signature motif; other site 320373012844 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 320373012845 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 320373012846 Uncharacterized conserved protein [Function unknown]; Region: COG5649 320373012847 Tannase and feruloyl esterase; Region: Tannase; pfam07519 320373012848 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373012849 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 320373012850 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373012851 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 320373012852 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320373012853 ligand binding site [chemical binding]; other site 320373012854 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 320373012855 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 320373012856 Walker A/P-loop; other site 320373012857 ATP binding site [chemical binding]; other site 320373012858 Q-loop/lid; other site 320373012859 ABC transporter signature motif; other site 320373012860 Walker B; other site 320373012861 D-loop; other site 320373012862 H-loop/switch region; other site 320373012863 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320373012864 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373012865 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373012866 TM-ABC transporter signature motif; other site 320373012867 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 320373012868 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 320373012869 Amidohydrolase; Region: Amidohydro_2; pfam04909 320373012870 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 320373012871 active site 320373012872 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 320373012873 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 320373012874 NAD binding site [chemical binding]; other site 320373012875 homotetramer interface [polypeptide binding]; other site 320373012876 homodimer interface [polypeptide binding]; other site 320373012877 active site 320373012878 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 320373012879 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 320373012880 short chain dehydrogenase; Provisional; Region: PRK08628 320373012881 classical (c) SDRs; Region: SDR_c; cd05233 320373012882 NAD(P) binding site [chemical binding]; other site 320373012883 active site 320373012884 Domain of unknown function (DUF718); Region: DUF718; cl01281 320373012885 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 320373012886 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320373012887 trimer interface [polypeptide binding]; other site 320373012888 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320373012889 YadA-like C-terminal region; Region: YadA; pfam03895 320373012890 H-NS histone family; Region: Histone_HNS; pfam00816 320373012891 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373012892 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 320373012893 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373012894 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373012895 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373012896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373012897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373012898 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320373012899 CoenzymeA binding site [chemical binding]; other site 320373012900 subunit interaction site [polypeptide binding]; other site 320373012901 PHB binding site; other site 320373012902 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 320373012903 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 320373012904 dimerization interface [polypeptide binding]; other site 320373012905 ligand binding site [chemical binding]; other site 320373012906 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 320373012907 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 320373012908 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 320373012909 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 320373012910 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 320373012911 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320373012912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373012913 metal binding site [ion binding]; metal-binding site 320373012914 active site 320373012915 I-site; other site 320373012916 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373012917 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373012918 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 320373012919 AsnC family; Region: AsnC_trans_reg; pfam01037 320373012920 aromatic amino acid transporter; Provisional; Region: PRK10238 320373012921 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 320373012922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373012923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373012924 homodimer interface [polypeptide binding]; other site 320373012925 catalytic residue [active] 320373012926 Protein of unknown function, DUF488; Region: DUF488; cl01246 320373012927 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 320373012928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373012929 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 320373012930 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 320373012931 PAS fold; Region: PAS; pfam00989 320373012932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373012933 putative active site [active] 320373012934 heme pocket [chemical binding]; other site 320373012935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373012936 ATP binding site [chemical binding]; other site 320373012937 G-X-G motif; other site 320373012938 Response regulator receiver domain; Region: Response_reg; pfam00072 320373012939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373012940 active site 320373012941 phosphorylation site [posttranslational modification] 320373012942 intermolecular recognition site; other site 320373012943 dimerization interface [polypeptide binding]; other site 320373012944 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 320373012945 Transglycosylase; Region: Transgly; pfam00912 320373012946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320373012947 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 320373012948 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 320373012949 MG2 domain; Region: A2M_N; pfam01835 320373012950 Alpha-2-macroglobulin family; Region: A2M; pfam00207 320373012951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 320373012952 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 320373012953 putative active site pocket [active] 320373012954 dimerization interface [polypeptide binding]; other site 320373012955 putative catalytic residue [active] 320373012956 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320373012957 active site 320373012958 HIGH motif; other site 320373012959 nucleotide binding site [chemical binding]; other site 320373012960 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320373012961 active site 320373012962 KMSKS motif; other site 320373012963 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 320373012964 tRNA binding surface [nucleotide binding]; other site 320373012965 anticodon binding site; other site 320373012966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373012967 S-adenosylmethionine binding site [chemical binding]; other site 320373012968 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 320373012969 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320373012970 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 320373012971 substrate binding pocket [chemical binding]; other site 320373012972 active site 320373012973 iron coordination sites [ion binding]; other site 320373012974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373012975 S-adenosylmethionine binding site [chemical binding]; other site 320373012976 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 320373012977 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373012978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373012979 catalytic residue [active] 320373012980 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 320373012981 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 320373012982 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320373012983 putative monooxygenase; Reviewed; Region: PRK07045 320373012984 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320373012985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 320373012986 sequence-specific DNA binding site [nucleotide binding]; other site 320373012987 salt bridge; other site 320373012988 Cupin domain; Region: Cupin_2; pfam07883 320373012989 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 320373012990 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 320373012991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373012992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373012993 active site 320373012994 phosphorylation site [posttranslational modification] 320373012995 intermolecular recognition site; other site 320373012996 dimerization interface [polypeptide binding]; other site 320373012997 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373012998 DNA binding residues [nucleotide binding] 320373012999 dimerization interface [polypeptide binding]; other site 320373013000 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373013001 Ligand Binding Site [chemical binding]; other site 320373013002 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373013003 Ligand Binding Site [chemical binding]; other site 320373013004 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373013005 Ligand Binding Site [chemical binding]; other site 320373013006 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373013007 Ligand Binding Site [chemical binding]; other site 320373013008 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373013009 Ligand Binding Site [chemical binding]; other site 320373013010 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373013011 Ligand Binding Site [chemical binding]; other site 320373013012 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 320373013013 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 320373013014 catalytic Zn binding site [ion binding]; other site 320373013015 structural Zn binding site [ion binding]; other site 320373013016 NAD(P) binding site [chemical binding]; other site 320373013017 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 320373013018 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 320373013019 active site residue [active] 320373013020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373013021 NAD(P) binding site [chemical binding]; other site 320373013022 active site 320373013023 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 320373013024 Spore germination protein; Region: Spore_permease; cl17796 320373013025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373013026 sequence-specific DNA binding site [nucleotide binding]; other site 320373013027 salt bridge; other site 320373013028 H-NS histone family; Region: Histone_HNS; pfam00816 320373013029 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373013030 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 320373013031 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 320373013032 Flavin binding site [chemical binding]; other site 320373013033 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 320373013034 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 320373013035 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 320373013036 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 320373013037 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 320373013038 active site 320373013039 non-prolyl cis peptide bond; other site 320373013040 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 320373013041 active site 320373013042 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 320373013043 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 320373013044 substrate binding site [chemical binding]; other site 320373013045 dimer interface [polypeptide binding]; other site 320373013046 ATP binding site [chemical binding]; other site 320373013047 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 320373013048 DEAD/DEAH box helicase; Region: DEAD; pfam00270 320373013049 DEAD_2; Region: DEAD_2; pfam06733 320373013050 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 320373013051 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 320373013052 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 320373013053 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 320373013054 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 320373013055 flagellar capping protein; Reviewed; Region: fliD; PRK08032 320373013056 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 320373013057 transcriptional regulator; Provisional; Region: PRK10632 320373013058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373013059 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373013060 putative effector binding pocket; other site 320373013061 dimerization interface [polypeptide binding]; other site 320373013062 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 320373013063 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 320373013064 catalytic residues [active] 320373013065 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373013066 dimerization interface [polypeptide binding]; other site 320373013067 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 320373013068 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 320373013069 active site 320373013070 catalytic tetrad [active] 320373013071 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 320373013072 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 320373013073 classical (c) SDRs; Region: SDR_c; cd05233 320373013074 NAD(P) binding site [chemical binding]; other site 320373013075 active site 320373013076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373013077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373013078 DNA binding residues [nucleotide binding] 320373013079 dimerization interface [polypeptide binding]; other site 320373013080 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320373013081 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320373013082 NAD(P) binding site [chemical binding]; other site 320373013083 catalytic residues [active] 320373013084 hypothetical protein; Provisional; Region: PRK07481 320373013085 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373013086 inhibitor-cofactor binding pocket; inhibition site 320373013087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373013088 catalytic residue [active] 320373013089 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 320373013090 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 320373013091 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373013092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373013093 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373013094 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373013095 eyelet of channel; other site 320373013096 trimer interface [polypeptide binding]; other site 320373013097 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373013098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373013099 Coenzyme A binding pocket [chemical binding]; other site 320373013100 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320373013101 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 320373013102 FMN binding site [chemical binding]; other site 320373013103 active site 320373013104 substrate binding site [chemical binding]; other site 320373013105 catalytic residue [active] 320373013106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373013107 putative DNA binding site [nucleotide binding]; other site 320373013108 dimerization interface [polypeptide binding]; other site 320373013109 putative Zn2+ binding site [ion binding]; other site 320373013110 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373013111 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373013112 trimer interface [polypeptide binding]; other site 320373013113 eyelet of channel; other site 320373013114 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 320373013115 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 320373013116 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320373013117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 320373013118 FOG: CBS domain [General function prediction only]; Region: COG0517 320373013119 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 320373013120 dimerization interface [polypeptide binding]; other site 320373013121 active site 320373013122 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 320373013123 NADH/NADPH cofactor binding site [chemical binding]; other site 320373013124 Autoinducer synthetase; Region: Autoind_synth; cl17404 320373013125 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 320373013126 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320373013127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373013128 DNA binding residues [nucleotide binding] 320373013129 dimerization interface [polypeptide binding]; other site 320373013130 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 320373013131 MgtC family; Region: MgtC; pfam02308 320373013132 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 320373013133 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320373013134 putative active site [active] 320373013135 putative metal binding site [ion binding]; other site 320373013136 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 320373013137 putative FMN binding site [chemical binding]; other site 320373013138 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 320373013139 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320373013140 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373013141 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373013142 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373013143 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373013144 trimer interface [polypeptide binding]; other site 320373013145 eyelet of channel; other site 320373013146 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 320373013147 [2Fe-2S] cluster binding site [ion binding]; other site 320373013148 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320373013149 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320373013150 [2Fe-2S] cluster binding site [ion binding]; other site 320373013151 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 320373013152 hydrophobic ligand binding site; other site 320373013153 short chain dehydrogenase; Provisional; Region: PRK12939 320373013154 classical (c) SDRs; Region: SDR_c; cd05233 320373013155 NAD(P) binding site [chemical binding]; other site 320373013156 active site 320373013157 Cupin domain; Region: Cupin_2; pfam07883 320373013158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320373013159 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 320373013160 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373013161 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373013162 short chain dehydrogenase; Provisional; Region: PRK07062 320373013163 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 320373013164 putative NAD(P) binding site [chemical binding]; other site 320373013165 putative active site [active] 320373013166 hypothetical protein; Provisional; Region: PRK07064 320373013167 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373013168 PYR/PP interface [polypeptide binding]; other site 320373013169 dimer interface [polypeptide binding]; other site 320373013170 TPP binding site [chemical binding]; other site 320373013171 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373013172 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 320373013173 TPP-binding site [chemical binding]; other site 320373013174 L-aspartate dehydrogenase; Provisional; Region: PRK13303 320373013175 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 320373013176 Domain of unknown function DUF108; Region: DUF108; pfam01958 320373013177 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320373013178 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 320373013179 NAD(P) binding site [chemical binding]; other site 320373013180 catalytic residues [active] 320373013181 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 320373013182 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 320373013183 active site 320373013184 metal binding site [ion binding]; metal-binding site 320373013185 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 320373013186 putative active site [active] 320373013187 putative metal binding site [ion binding]; other site 320373013188 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 320373013189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373013190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373013191 benzoate transport; Region: 2A0115; TIGR00895 320373013192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373013193 putative substrate translocation pore; other site 320373013194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373013195 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320373013196 trimer interface [polypeptide binding]; other site 320373013197 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320373013198 trimer interface [polypeptide binding]; other site 320373013199 Haemagglutinin; Region: HIM; pfam05662 320373013200 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320373013201 trimer interface [polypeptide binding]; other site 320373013202 Haemagglutinin; Region: HIM; pfam05662 320373013203 Haemagglutinin; Region: HIM; pfam05662 320373013204 YadA-like C-terminal region; Region: YadA; pfam03895 320373013205 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 320373013206 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 320373013207 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373013208 ligand binding site [chemical binding]; other site 320373013209 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373013210 Ligand Binding Site [chemical binding]; other site 320373013211 amidase; Provisional; Region: PRK07486 320373013212 Amidase; Region: Amidase; pfam01425 320373013213 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373013214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373013215 dimerization interface [polypeptide binding]; other site 320373013216 putative DNA binding site [nucleotide binding]; other site 320373013217 putative Zn2+ binding site [ion binding]; other site 320373013218 AsnC family; Region: AsnC_trans_reg; pfam01037 320373013219 methionine gamma-lyase; Validated; Region: PRK07049 320373013220 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 320373013221 homodimer interface [polypeptide binding]; other site 320373013222 substrate-cofactor binding pocket; other site 320373013223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373013224 catalytic residue [active] 320373013225 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 320373013226 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 320373013227 Predicted transcriptional regulator [Transcription]; Region: COG1959 320373013228 Transcriptional regulator; Region: Rrf2; pfam02082 320373013229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 320373013230 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373013231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373013232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373013233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373013234 dimerization interface [polypeptide binding]; other site 320373013235 hypothetical protein; Provisional; Region: PRK07079 320373013236 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 320373013237 metal binding site [ion binding]; metal-binding site 320373013238 putative dimer interface [polypeptide binding]; other site 320373013239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373013240 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373013241 putative substrate translocation pore; other site 320373013242 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373013243 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373013244 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 320373013245 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 320373013246 short chain dehydrogenase; Provisional; Region: PRK07832 320373013247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373013248 NAD(P) binding site [chemical binding]; other site 320373013249 active site 320373013250 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 320373013251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 320373013252 YhhN-like protein; Region: YhhN; pfam07947 320373013253 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 320373013254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373013255 substrate binding pocket [chemical binding]; other site 320373013256 membrane-bound complex binding site; other site 320373013257 hinge residues; other site 320373013258 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 320373013259 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 320373013260 DNA binding residues [nucleotide binding] 320373013261 putative dimer interface [polypeptide binding]; other site 320373013262 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 320373013263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373013264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373013265 Coenzyme A binding pocket [chemical binding]; other site 320373013266 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320373013267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373013268 putative substrate translocation pore; other site 320373013269 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320373013270 Tar ligand binding domain homologue; Region: TarH; pfam02203 320373013271 dimer interface [polypeptide binding]; other site 320373013272 ligand binding site [chemical binding]; other site 320373013273 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 320373013274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373013275 dimerization interface [polypeptide binding]; other site 320373013276 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373013277 dimer interface [polypeptide binding]; other site 320373013278 putative CheW interface [polypeptide binding]; other site 320373013279 Family description; Region: UvrD_C_2; pfam13538 320373013280 BetR domain; Region: BetR; pfam08667 320373013281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373013282 active site 320373013283 phosphorylation site [posttranslational modification] 320373013284 intermolecular recognition site; other site 320373013285 dimerization interface [polypeptide binding]; other site 320373013286 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 320373013287 hydroxyglutarate oxidase; Provisional; Region: PRK11728 320373013288 Ion channel; Region: Ion_trans_2; pfam07885 320373013289 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 320373013290 TrkA-N domain; Region: TrkA_N; pfam02254 320373013291 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373013292 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 320373013293 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 320373013294 ornithine cyclodeaminase; Validated; Region: PRK07340 320373013295 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 320373013296 Putative esterase; Region: Esterase; pfam00756 320373013297 OpgC protein; Region: OpgC_C; pfam10129 320373013298 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373013299 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373013300 trimer interface [polypeptide binding]; other site 320373013301 eyelet of channel; other site 320373013302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373013303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373013304 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 320373013305 putative dimerization interface [polypeptide binding]; other site 320373013306 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320373013307 Peptidase family M23; Region: Peptidase_M23; pfam01551 320373013308 beta-lactamase TEM; Provisional; Region: PRK15442 320373013309 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 320373013310 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320373013311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373013312 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320373013313 substrate binding pocket [chemical binding]; other site 320373013314 dimerization interface [polypeptide binding]; other site 320373013315 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 320373013316 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373013317 Walker A/P-loop; other site 320373013318 ATP binding site [chemical binding]; other site 320373013319 Q-loop/lid; other site 320373013320 ABC transporter signature motif; other site 320373013321 Walker B; other site 320373013322 D-loop; other site 320373013323 H-loop/switch region; other site 320373013324 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 320373013325 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373013326 Walker A/P-loop; other site 320373013327 ATP binding site [chemical binding]; other site 320373013328 Q-loop/lid; other site 320373013329 ABC transporter signature motif; other site 320373013330 Walker B; other site 320373013331 D-loop; other site 320373013332 H-loop/switch region; other site 320373013333 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 320373013334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373013335 dimer interface [polypeptide binding]; other site 320373013336 conserved gate region; other site 320373013337 putative PBP binding loops; other site 320373013338 ABC-ATPase subunit interface; other site 320373013339 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 320373013340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373013341 dimer interface [polypeptide binding]; other site 320373013342 conserved gate region; other site 320373013343 putative PBP binding loops; other site 320373013344 ABC-ATPase subunit interface; other site 320373013345 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 320373013346 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 320373013347 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 320373013348 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320373013349 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320373013350 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 320373013351 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320373013352 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373013353 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373013354 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 320373013355 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 320373013356 PAAR motif; Region: PAAR_motif; pfam05488 320373013357 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 320373013358 RHS Repeat; Region: RHS_repeat; cl11982 320373013359 RHS Repeat; Region: RHS_repeat; pfam05593 320373013360 RHS Repeat; Region: RHS_repeat; cl11982 320373013361 RHS Repeat; Region: RHS_repeat; pfam05593 320373013362 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 320373013363 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 320373013364 RHS Repeat; Region: RHS_repeat; pfam05593 320373013365 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 320373013366 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 320373013367 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 320373013368 catalytic triad [active] 320373013369 putative active site [active] 320373013370 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 320373013371 Autotransporter beta-domain; Region: Autotransporter; smart00869 320373013372 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 320373013373 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 320373013374 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 320373013375 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 320373013376 Cupin; Region: Cupin_1; smart00835 320373013377 Cupin; Region: Cupin_1; smart00835 320373013378 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 320373013379 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 320373013380 Predicted membrane protein [Function unknown]; Region: COG4682 320373013381 yiaA/B two helix domain; Region: YiaAB; pfam05360 320373013382 yiaA/B two helix domain; Region: YiaAB; pfam05360 320373013383 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 320373013384 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 320373013385 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 320373013386 putative molybdopterin cofactor binding site [chemical binding]; other site 320373013387 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 320373013388 putative molybdopterin cofactor binding site; other site 320373013389 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373013390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373013391 DNA-binding site [nucleotide binding]; DNA binding site 320373013392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373013393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373013394 homodimer interface [polypeptide binding]; other site 320373013395 catalytic residue [active] 320373013396 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 320373013397 magnesium-transporting ATPase; Provisional; Region: PRK15122 320373013398 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 320373013399 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320373013400 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 320373013401 Soluble P-type ATPase [General function prediction only]; Region: COG4087 320373013402 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 320373013403 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 320373013404 active site 320373013405 catalytic triad [active] 320373013406 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 320373013407 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 320373013408 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320373013409 Cytochrome c; Region: Cytochrom_C; pfam00034 320373013410 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373013411 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373013412 Cytochrome c; Region: Cytochrom_C; pfam00034 320373013413 Predicted membrane protein [Function unknown]; Region: COG2259 320373013414 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373013415 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373013416 trimer interface [polypeptide binding]; other site 320373013417 eyelet of channel; other site 320373013418 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 320373013419 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320373013420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373013421 dimer interface [polypeptide binding]; other site 320373013422 conserved gate region; other site 320373013423 putative PBP binding loops; other site 320373013424 ABC-ATPase subunit interface; other site 320373013425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373013426 dimer interface [polypeptide binding]; other site 320373013427 conserved gate region; other site 320373013428 putative PBP binding loops; other site 320373013429 ABC-ATPase subunit interface; other site 320373013430 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 320373013431 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320373013432 Walker A/P-loop; other site 320373013433 ATP binding site [chemical binding]; other site 320373013434 Q-loop/lid; other site 320373013435 ABC transporter signature motif; other site 320373013436 Walker B; other site 320373013437 D-loop; other site 320373013438 H-loop/switch region; other site 320373013439 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 320373013440 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 320373013441 putative active site [active] 320373013442 Uncharacterized conserved protein [Function unknown]; Region: COG3791 320373013443 H+ Antiporter protein; Region: 2A0121; TIGR00900 320373013444 Histidine kinase; Region: His_kinase; pfam06580 320373013445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373013446 ATP binding site [chemical binding]; other site 320373013447 Mg2+ binding site [ion binding]; other site 320373013448 G-X-G motif; other site 320373013449 Response regulator receiver domain; Region: Response_reg; pfam00072 320373013450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373013451 active site 320373013452 phosphorylation site [posttranslational modification] 320373013453 intermolecular recognition site; other site 320373013454 dimerization interface [polypeptide binding]; other site 320373013455 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 320373013456 LytTr DNA-binding domain; Region: LytTR; smart00850 320373013457 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 320373013458 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 320373013459 tetramer interface [polypeptide binding]; other site 320373013460 heme binding pocket [chemical binding]; other site 320373013461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373013462 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373013463 S-adenosylmethionine binding site [chemical binding]; other site 320373013464 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 320373013465 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373013466 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320373013467 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 320373013468 iron-sulfur cluster [ion binding]; other site 320373013469 [2Fe-2S] cluster binding site [ion binding]; other site 320373013470 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 320373013471 hydrophobic ligand binding site; other site 320373013472 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 320373013473 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 320373013474 dimer interface [polypeptide binding]; other site 320373013475 active site 320373013476 acyl carrier protein; Validated; Region: PRK07117 320373013477 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 320373013478 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373013479 substrate binding site [chemical binding]; other site 320373013480 oxyanion hole (OAH) forming residues; other site 320373013481 trimer interface [polypeptide binding]; other site 320373013482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373013483 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 320373013484 substrate binding site [chemical binding]; other site 320373013485 oxyanion hole (OAH) forming residues; other site 320373013486 trimer interface [polypeptide binding]; other site 320373013487 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 320373013488 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 320373013489 dimer interface [polypeptide binding]; other site 320373013490 active site 320373013491 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320373013492 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 320373013493 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 320373013494 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013495 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013496 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320373013497 active site 320373013498 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320373013499 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320373013500 KR domain; Region: KR; pfam08659 320373013501 putative NADP binding site [chemical binding]; other site 320373013502 active site 320373013503 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013504 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 320373013505 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 320373013506 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373013507 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373013508 catalytic residue [active] 320373013509 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013510 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373013511 active site 320373013512 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013513 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373013514 active site 320373013515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013516 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013517 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013518 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013519 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013520 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373013521 active site 320373013522 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320373013523 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320373013524 putative NADP binding site [chemical binding]; other site 320373013525 KR domain; Region: KR; pfam08659 320373013526 active site 320373013527 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013528 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013529 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373013530 active site 320373013531 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013532 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013533 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013534 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373013535 active site 320373013536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373013537 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320373013538 NAD(P) binding site [chemical binding]; other site 320373013539 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320373013540 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373013541 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013542 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013543 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373013544 active site 320373013545 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013546 Condensation domain; Region: Condensation; pfam00668 320373013547 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373013548 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373013549 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373013550 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373013551 acyl-activating enzyme (AAE) consensus motif; other site 320373013552 AMP binding site [chemical binding]; other site 320373013553 active site 320373013554 CoA binding site [chemical binding]; other site 320373013555 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013556 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373013557 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013558 active site 320373013559 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320373013560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373013561 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320373013562 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013563 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013564 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320373013565 active site 320373013566 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320373013567 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320373013568 putative NADP binding site [chemical binding]; other site 320373013569 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320373013570 active site 320373013571 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373013572 Methyltransferase domain; Region: Methyltransf_12; pfam08242 320373013573 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013574 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013575 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013576 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 320373013577 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373013578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373013579 catalytic residue [active] 320373013580 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 320373013581 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013582 active site 320373013583 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 320373013584 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320373013585 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 320373013586 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 320373013587 Cl- selectivity filter; other site 320373013588 Cl- binding residues [ion binding]; other site 320373013589 pore gating glutamate residue; other site 320373013590 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 320373013591 MarR family; Region: MarR_2; pfam12802 320373013592 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 320373013593 HPP family; Region: HPP; pfam04982 320373013594 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 320373013595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373013596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373013597 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373013598 putative effector binding pocket; other site 320373013599 dimerization interface [polypeptide binding]; other site 320373013600 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 320373013601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373013602 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 320373013603 CAAX protease self-immunity; Region: Abi; cl00558 320373013604 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 320373013605 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 320373013606 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373013607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373013608 RNA polymerase sigma factor; Provisional; Region: PRK12547 320373013609 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373013610 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373013611 DNA binding residues [nucleotide binding] 320373013612 YceI-like domain; Region: YceI; pfam04264 320373013613 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 320373013614 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 320373013615 RNA polymerase sigma factor; Provisional; Region: PRK12528 320373013616 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373013617 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373013618 DNA binding residues [nucleotide binding] 320373013619 fec operon regulator FecR; Reviewed; Region: PRK09774 320373013620 FecR protein; Region: FecR; pfam04773 320373013621 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 320373013622 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373013623 N-terminal plug; other site 320373013624 ligand-binding site [chemical binding]; other site 320373013625 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 320373013626 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373013627 TM-ABC transporter signature motif; other site 320373013628 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 320373013629 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 320373013630 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 320373013631 Walker A/P-loop; other site 320373013632 ATP binding site [chemical binding]; other site 320373013633 Q-loop/lid; other site 320373013634 ABC transporter signature motif; other site 320373013635 Walker B; other site 320373013636 D-loop; other site 320373013637 H-loop/switch region; other site 320373013638 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 320373013639 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 320373013640 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 320373013641 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 320373013642 putative ligand binding site [chemical binding]; other site 320373013643 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 320373013644 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 320373013645 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 320373013646 Flavin binding site [chemical binding]; other site 320373013647 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 320373013648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373013649 putative substrate translocation pore; other site 320373013650 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320373013651 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 320373013652 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373013653 dimerization interface [polypeptide binding]; other site 320373013654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373013655 dimer interface [polypeptide binding]; other site 320373013656 phosphorylation site [posttranslational modification] 320373013657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373013658 ATP binding site [chemical binding]; other site 320373013659 Mg2+ binding site [ion binding]; other site 320373013660 G-X-G motif; other site 320373013661 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 320373013662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373013663 active site 320373013664 phosphorylation site [posttranslational modification] 320373013665 intermolecular recognition site; other site 320373013666 dimerization interface [polypeptide binding]; other site 320373013667 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373013668 DNA binding site [nucleotide binding] 320373013669 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 320373013670 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373013671 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 320373013672 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373013673 Outer membrane efflux protein; Region: OEP; pfam02321 320373013674 Outer membrane efflux protein; Region: OEP; pfam02321 320373013675 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 320373013676 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 320373013677 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 320373013678 dimer interface [polypeptide binding]; other site 320373013679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373013680 catalytic residue [active] 320373013681 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 320373013682 putative deacylase active site [active] 320373013683 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 320373013684 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 320373013685 hexamer interface [polypeptide binding]; other site 320373013686 ligand binding site [chemical binding]; other site 320373013687 putative active site [active] 320373013688 NAD(P) binding site [chemical binding]; other site 320373013689 H-NS histone family; Region: Histone_HNS; pfam00816 320373013690 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373013691 ProQ/FINO family; Region: ProQ; pfam04352 320373013692 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 320373013693 putative RNA binding sites [nucleotide binding]; other site 320373013694 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 320373013695 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 320373013696 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 320373013697 nucleotide binding site [chemical binding]; other site 320373013698 putative NEF/HSP70 interaction site [polypeptide binding]; other site 320373013699 SBD interface [polypeptide binding]; other site 320373013700 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 320373013701 nucleotide binding site [chemical binding]; other site 320373013702 putative NEF/HSP70 interaction site [polypeptide binding]; other site 320373013703 SBD interface [polypeptide binding]; other site 320373013704 DNA-K related protein; Region: DUF3731; pfam12531 320373013705 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 320373013706 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 320373013707 putative active site [active] 320373013708 putative metal binding site [ion binding]; other site 320373013709 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 320373013710 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 320373013711 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 320373013712 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 320373013713 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 320373013714 Soluble P-type ATPase [General function prediction only]; Region: COG4087 320373013715 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 320373013716 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373013717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373013718 S-adenosylmethionine binding site [chemical binding]; other site 320373013719 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 320373013720 Mannan-binding protein; Region: MVL; pfam12151 320373013721 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 320373013722 dimer interface [polypeptide binding]; other site 320373013723 substrate binding site [chemical binding]; other site 320373013724 ATP binding site [chemical binding]; other site 320373013725 Methyltransferase domain; Region: Methyltransf_11; pfam08241 320373013726 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 320373013727 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 320373013728 dimerization interface [polypeptide binding]; other site 320373013729 active site 320373013730 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 320373013731 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 320373013732 nudix motif; other site 320373013733 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373013734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373013735 S-adenosylmethionine binding site [chemical binding]; other site 320373013736 Protein of unknown function (DUF971); Region: DUF971; cl01414 320373013737 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 320373013738 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 320373013739 substrate binding pocket [chemical binding]; other site 320373013740 active site 320373013741 iron coordination sites [ion binding]; other site 320373013742 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 320373013743 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 320373013744 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 320373013745 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 320373013746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373013747 Walker A motif; other site 320373013748 ATP binding site [chemical binding]; other site 320373013749 Walker B motif; other site 320373013750 arginine finger; other site 320373013751 Peptidase family M41; Region: Peptidase_M41; pfam01434 320373013752 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 320373013753 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320373013754 active site 320373013755 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320373013756 Predicted transcriptional regulator [Transcription]; Region: COG2345 320373013757 MarR family; Region: MarR_2; pfam12802 320373013758 Transcriptional regulator PadR-like family; Region: PadR; cl17335 320373013759 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 320373013760 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 320373013761 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373013762 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373013763 multidrug efflux protein; Reviewed; Region: PRK09579 320373013764 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 320373013765 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 320373013766 dimerization interface [polypeptide binding]; other site 320373013767 active site 320373013768 FOG: WD40 repeat [General function prediction only]; Region: COG2319 320373013769 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 320373013770 structural tetrad; other site 320373013771 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 320373013772 structural tetrad; other site 320373013773 FOG: WD40 repeat [General function prediction only]; Region: COG2319 320373013774 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373013775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373013776 S-adenosylmethionine binding site [chemical binding]; other site 320373013777 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 320373013778 Uncharacterized conserved protein [Function unknown]; Region: COG1262 320373013779 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 320373013780 catalytic motif [active] 320373013781 Zn binding site [ion binding]; other site 320373013782 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 320373013783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373013784 S-adenosylmethionine binding site [chemical binding]; other site 320373013785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373013786 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 320373013787 active site 320373013788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373013789 putative substrate translocation pore; other site 320373013790 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 320373013791 PAS fold; Region: PAS_4; pfam08448 320373013792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373013793 DNA binding residues [nucleotide binding] 320373013794 dimerization interface [polypeptide binding]; other site 320373013795 SnoaL-like domain; Region: SnoaL_2; pfam12680 320373013796 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320373013797 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 320373013798 active site 320373013799 FMN binding site [chemical binding]; other site 320373013800 2,4-decadienoyl-CoA binding site; other site 320373013801 catalytic residue [active] 320373013802 4Fe-4S cluster binding site [ion binding]; other site 320373013803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 320373013804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373013805 Predicted transcriptional regulators [Transcription]; Region: COG1695 320373013806 Transcriptional regulator PadR-like family; Region: PadR; cl17335 320373013807 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 320373013808 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 320373013809 substrate binding site [chemical binding]; other site 320373013810 multimerization interface [polypeptide binding]; other site 320373013811 ATP binding site [chemical binding]; other site 320373013812 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320373013813 substrate binding pocket [chemical binding]; other site 320373013814 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 320373013815 active site 320373013816 iron coordination sites [ion binding]; other site 320373013817 Membrane transport protein; Region: Mem_trans; cl09117 320373013818 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 320373013819 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 320373013820 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373013821 Ligand Binding Site [chemical binding]; other site 320373013822 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373013823 Ligand Binding Site [chemical binding]; other site 320373013824 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 320373013825 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 320373013826 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 320373013827 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 320373013828 hydrogenase 4 subunit F; Validated; Region: PRK06458 320373013829 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320373013830 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 320373013831 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 320373013832 NADH dehydrogenase; Region: NADHdh; cl00469 320373013833 hydrogenase 4 subunit B; Validated; Region: PRK06521 320373013834 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 320373013835 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 320373013836 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 320373013837 regulatory phosphorylation site [posttranslational modification]; other site 320373013838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373013839 S-adenosylmethionine binding site [chemical binding]; other site 320373013840 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 320373013841 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 320373013842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373013843 putative substrate translocation pore; other site 320373013844 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320373013845 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 320373013846 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 320373013847 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 320373013848 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 320373013849 4Fe-4S binding domain; Region: Fer4; cl02805 320373013850 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 320373013851 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 320373013852 [4Fe-4S] binding site [ion binding]; other site 320373013853 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373013854 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373013855 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373013856 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 320373013857 molybdopterin cofactor binding site; other site 320373013858 CHASE domain; Region: CHASE; cl01369 320373013859 PAS domain S-box; Region: sensory_box; TIGR00229 320373013860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373013861 putative active site [active] 320373013862 heme pocket [chemical binding]; other site 320373013863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 320373013864 Histidine kinase; Region: HisKA_3; pfam07730 320373013865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373013866 ATP binding site [chemical binding]; other site 320373013867 Mg2+ binding site [ion binding]; other site 320373013868 G-X-G motif; other site 320373013869 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373013870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373013871 active site 320373013872 phosphorylation site [posttranslational modification] 320373013873 intermolecular recognition site; other site 320373013874 dimerization interface [polypeptide binding]; other site 320373013875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373013876 DNA binding residues [nucleotide binding] 320373013877 dimerization interface [polypeptide binding]; other site 320373013878 Response regulator receiver domain; Region: Response_reg; pfam00072 320373013879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373013880 active site 320373013881 phosphorylation site [posttranslational modification] 320373013882 intermolecular recognition site; other site 320373013883 dimerization interface [polypeptide binding]; other site 320373013884 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 320373013885 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320373013886 ligand binding site [chemical binding]; other site 320373013887 flexible hinge region; other site 320373013888 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 320373013889 putative switch regulator; other site 320373013890 non-specific DNA interactions [nucleotide binding]; other site 320373013891 DNA binding site [nucleotide binding] 320373013892 sequence specific DNA binding site [nucleotide binding]; other site 320373013893 putative cAMP binding site [chemical binding]; other site 320373013894 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 320373013895 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 320373013896 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320373013897 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 320373013898 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 320373013899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373013900 putative substrate translocation pore; other site 320373013901 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 320373013902 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 320373013903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 320373013904 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 320373013905 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013906 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373013907 active site 320373013908 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013909 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 320373013910 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373013911 acyl-activating enzyme (AAE) consensus motif; other site 320373013912 AMP binding site [chemical binding]; other site 320373013913 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013914 Condensation domain; Region: Condensation; pfam00668 320373013915 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373013916 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373013917 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320373013918 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013919 active site 320373013920 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320373013921 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320373013922 putative NADP binding site [chemical binding]; other site 320373013923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373013924 NAD(P) binding site [chemical binding]; other site 320373013925 active site 320373013926 active site 320373013927 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013928 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373013929 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320373013930 active site 320373013931 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320373013932 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 320373013933 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320373013934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373013935 NAD(P) binding site [chemical binding]; other site 320373013936 active site 320373013937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013938 Condensation domain; Region: Condensation; pfam00668 320373013939 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373013940 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 320373013941 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373013942 acyl-activating enzyme (AAE) consensus motif; other site 320373013943 AMP binding site [chemical binding]; other site 320373013944 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013945 Condensation domain; Region: Condensation; pfam00668 320373013946 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373013947 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373013948 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 320373013949 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 320373013950 active site 320373013951 Zn binding site [ion binding]; other site 320373013952 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 320373013953 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320373013954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373013955 DNA binding residues [nucleotide binding] 320373013956 dimerization interface [polypeptide binding]; other site 320373013957 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320373013958 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 320373013959 Autoinducer synthetase; Region: Autoind_synth; cl17404 320373013960 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 320373013961 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373013962 acyl-activating enzyme (AAE) consensus motif; other site 320373013963 AMP binding site [chemical binding]; other site 320373013964 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013965 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 320373013966 shikimate transporter; Provisional; Region: PRK09952 320373013967 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373013968 acyl-CoA synthetase; Validated; Region: PRK05850 320373013969 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373013970 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 320373013971 acyl-activating enzyme (AAE) consensus motif; other site 320373013972 acyl-activating enzyme (AAE) consensus motif; other site 320373013973 active site 320373013974 AMP binding site [chemical binding]; other site 320373013975 active site 320373013976 AMP binding site [chemical binding]; other site 320373013977 CoA binding site [chemical binding]; other site 320373013978 CoA binding site [chemical binding]; other site 320373013979 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 320373013980 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 320373013981 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 320373013982 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373013983 catalytic residue [active] 320373013984 Condensation domain; Region: Condensation; pfam00668 320373013985 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 320373013986 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373013987 acyl-activating enzyme (AAE) consensus motif; other site 320373013988 AMP binding site [chemical binding]; other site 320373013989 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013990 Condensation domain; Region: Condensation; pfam00668 320373013991 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373013992 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373013993 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373013994 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373013995 acyl-activating enzyme (AAE) consensus motif; other site 320373013996 AMP binding site [chemical binding]; other site 320373013997 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373013998 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 320373013999 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320373014000 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373014001 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 320373014002 active site 320373014003 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320373014004 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 320373014005 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373014006 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373014007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373014008 catalytic residue [active] 320373014009 Condensation domain; Region: Condensation; pfam00668 320373014010 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373014011 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373014012 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373014013 acyl-activating enzyme (AAE) consensus motif; other site 320373014014 AMP binding site [chemical binding]; other site 320373014015 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373014016 Condensation domain; Region: Condensation; pfam00668 320373014017 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 320373014018 major capsid protein; Region: PHA00665 320373014019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373014020 DNA-binding site [nucleotide binding]; DNA binding site 320373014021 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373014022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373014023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373014024 homodimer interface [polypeptide binding]; other site 320373014025 catalytic residue [active] 320373014026 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 320373014027 Uncharacterized conserved protein [Function unknown]; Region: COG2128 320373014028 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 320373014029 Predicted small secreted protein [Function unknown]; Region: COG5510 320373014030 aspartate carbamoyltransferase; Provisional; Region: PRK11891 320373014031 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 320373014032 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 320373014033 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 320373014034 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373014035 N-terminal plug; other site 320373014036 ligand-binding site [chemical binding]; other site 320373014037 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 320373014038 Sel1 repeat; Region: Sel1; cl02723 320373014039 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 320373014040 Transposase, Mutator family; Region: Transposase_mut; pfam00872 320373014041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 320373014042 Transposase; Region: HTH_Tnp_1; cl17663 320373014043 Uncharacterized conserved protein [Function unknown]; Region: COG4104 320373014044 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 320373014045 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 320373014046 DDE domain; Region: DDE_Tnp_IS240; pfam13610 320373014047 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 320373014048 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 320373014049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320373014050 active site 320373014051 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320373014052 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 320373014053 putative C-terminal domain interface [polypeptide binding]; other site 320373014054 putative GSH binding site (G-site) [chemical binding]; other site 320373014055 putative dimer interface [polypeptide binding]; other site 320373014056 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 320373014057 putative N-terminal domain interface [polypeptide binding]; other site 320373014058 putative dimer interface [polypeptide binding]; other site 320373014059 putative substrate binding pocket (H-site) [chemical binding]; other site 320373014060 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 320373014061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 320373014062 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 320373014063 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 320373014064 Active Sites [active] 320373014065 DDE domain; Region: DDE_Tnp_IS240; pfam13610 320373014066 DDE domain; Region: DDE_Tnp_IS240; pfam13610 320373014067 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 320373014068 metal-binding site 320373014069 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 320373014070 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 320373014071 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373014072 dimer interface [polypeptide binding]; other site 320373014073 putative CheW interface [polypeptide binding]; other site 320373014074 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 320373014075 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320373014076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320373014077 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 320373014078 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 320373014079 ligand binding site [chemical binding]; other site 320373014080 short chain dehydrogenase; Provisional; Region: PRK07074 320373014081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373014082 NAD(P) binding site [chemical binding]; other site 320373014083 active site 320373014084 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 320373014085 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 320373014086 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 320373014087 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 320373014088 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 320373014089 substrate binding pocket [chemical binding]; other site 320373014090 chain length determination region; other site 320373014091 substrate-Mg2+ binding site; other site 320373014092 catalytic residues [active] 320373014093 aspartate-rich region 1; other site 320373014094 active site lid residues [active] 320373014095 aspartate-rich region 2; other site 320373014096 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 320373014097 substrate binding pocket [chemical binding]; other site 320373014098 substrate-Mg2+ binding site; other site 320373014099 aspartate-rich region 1; other site 320373014100 aspartate-rich region 2; other site 320373014101 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 320373014102 putative cation:proton antiport protein; Provisional; Region: PRK10669 320373014103 TrkA-N domain; Region: TrkA_N; pfam02254 320373014104 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 320373014105 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 320373014106 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 320373014107 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 320373014108 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 320373014109 dimer interface [polypeptide binding]; other site 320373014110 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 320373014111 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 320373014112 Cl binding site [ion binding]; other site 320373014113 oligomer interface [polypeptide binding]; other site 320373014114 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 320373014115 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 320373014116 Electron transfer DM13; Region: DM13; pfam10517 320373014117 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 320373014118 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 320373014119 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 320373014120 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 320373014121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373014122 dimer interface [polypeptide binding]; other site 320373014123 conserved gate region; other site 320373014124 putative PBP binding loops; other site 320373014125 ABC-ATPase subunit interface; other site 320373014126 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 320373014127 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 320373014128 inhibitor binding site; inhibition site 320373014129 catalytic Zn binding site [ion binding]; other site 320373014130 structural Zn binding site [ion binding]; other site 320373014131 NADP binding site [chemical binding]; other site 320373014132 tetramer interface [polypeptide binding]; other site 320373014133 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 320373014134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373014135 Walker A/P-loop; other site 320373014136 ATP binding site [chemical binding]; other site 320373014137 Q-loop/lid; other site 320373014138 ABC transporter signature motif; other site 320373014139 Walker B; other site 320373014140 D-loop; other site 320373014141 H-loop/switch region; other site 320373014142 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320373014143 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 320373014144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373014145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373014146 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 320373014147 N- and C-terminal domain interface [polypeptide binding]; other site 320373014148 active site 320373014149 MgATP binding site [chemical binding]; other site 320373014150 catalytic site [active] 320373014151 metal binding site [ion binding]; metal-binding site 320373014152 xylulose binding site [chemical binding]; other site 320373014153 homodimer interface [polypeptide binding]; other site 320373014154 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 320373014155 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 320373014156 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 320373014157 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 320373014158 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 320373014159 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 320373014160 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 320373014161 [4Fe-4S] binding site [ion binding]; other site 320373014162 molybdopterin cofactor binding site; other site 320373014163 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 320373014164 molybdopterin cofactor binding site; other site 320373014165 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 320373014166 Flavodoxin; Region: Flavodoxin_1; pfam00258 320373014167 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 320373014168 FAD binding pocket [chemical binding]; other site 320373014169 FAD binding motif [chemical binding]; other site 320373014170 catalytic residues [active] 320373014171 NAD binding pocket [chemical binding]; other site 320373014172 phosphate binding motif [ion binding]; other site 320373014173 beta-alpha-beta structure motif; other site 320373014174 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 320373014175 nitrite reductase subunit NirD; Provisional; Region: PRK14989 320373014176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373014177 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 320373014178 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 320373014179 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 320373014180 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 320373014181 active site 320373014182 SAM binding site [chemical binding]; other site 320373014183 homodimer interface [polypeptide binding]; other site 320373014184 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 320373014185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373014186 active site 320373014187 phosphorylation site [posttranslational modification] 320373014188 intermolecular recognition site; other site 320373014189 dimerization interface [polypeptide binding]; other site 320373014190 ANTAR domain; Region: ANTAR; pfam03861 320373014191 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 320373014192 NMT1-like family; Region: NMT1_2; pfam13379 320373014193 GTP cyclohydrolase I; Reviewed; Region: PRK12606 320373014194 GTP cyclohydrolase I; Provisional; Region: PLN03044 320373014195 active site 320373014196 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 320373014197 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 320373014198 active site 320373014199 Zn binding site [ion binding]; other site 320373014200 allantoate amidohydrolase; Reviewed; Region: PRK12893 320373014201 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 320373014202 active site 320373014203 metal binding site [ion binding]; metal-binding site 320373014204 dimer interface [polypeptide binding]; other site 320373014205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014206 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373014207 putative substrate translocation pore; other site 320373014208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373014209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373014210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373014211 dimerization interface [polypeptide binding]; other site 320373014212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373014213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373014214 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 320373014215 putative effector binding pocket; other site 320373014216 putative dimerization interface [polypeptide binding]; other site 320373014217 short chain dehydrogenase; Provisional; Region: PRK12937 320373014218 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 320373014219 NADP binding site [chemical binding]; other site 320373014220 homodimer interface [polypeptide binding]; other site 320373014221 active site 320373014222 substrate binding site [chemical binding]; other site 320373014223 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320373014224 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320373014225 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 320373014226 Prostaglandin dehydrogenases; Region: PGDH; cd05288 320373014227 NAD(P) binding site [chemical binding]; other site 320373014228 substrate binding site [chemical binding]; other site 320373014229 dimer interface [polypeptide binding]; other site 320373014230 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 320373014231 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 320373014232 dimer interface [polypeptide binding]; other site 320373014233 active site 320373014234 metal binding site [ion binding]; metal-binding site 320373014235 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373014236 Peptidase M66; Region: Peptidase_M66; pfam10462 320373014237 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 320373014238 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 320373014239 Domain of unknown function (DUF802); Region: DUF802; pfam05650 320373014240 Domain of unknown function (DUF802); Region: DUF802; pfam05650 320373014241 hypothetical protein; Provisional; Region: PRK09040 320373014242 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373014243 ligand binding site [chemical binding]; other site 320373014244 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 320373014245 Condensation domain; Region: Condensation; pfam00668 320373014246 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373014247 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373014248 acyl-activating enzyme (AAE) consensus motif; other site 320373014249 AMP binding site [chemical binding]; other site 320373014250 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373014251 MbtH-like protein; Region: MbtH; pfam03621 320373014252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014253 putative substrate translocation pore; other site 320373014254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373014255 Condensation domain; Region: Condensation; pfam00668 320373014256 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373014257 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373014258 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373014259 acyl-activating enzyme (AAE) consensus motif; other site 320373014260 AMP binding site [chemical binding]; other site 320373014261 Condensation domain; Region: Condensation; pfam00668 320373014262 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373014263 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373014264 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373014265 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373014266 acyl-activating enzyme (AAE) consensus motif; other site 320373014267 AMP binding site [chemical binding]; other site 320373014268 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373014269 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 320373014270 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373014271 active site 320373014272 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 320373014273 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 320373014274 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320373014275 KR domain; Region: KR; pfam08659 320373014276 putative NADP binding site [chemical binding]; other site 320373014277 active site 320373014278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373014279 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 320373014280 Biofilm formation and stress response factor; Region: BsmA; pfam10014 320373014281 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373014282 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373014283 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 320373014284 active site 320373014285 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373014286 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 320373014287 active site 320373014288 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 320373014289 acyl-CoA synthetase; Validated; Region: PRK05850 320373014290 acyl-activating enzyme (AAE) consensus motif; other site 320373014291 active site 320373014292 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 320373014293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373014294 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373014295 DNA binding residues [nucleotide binding] 320373014296 Uncharacterized conserved protein [Function unknown]; Region: COG1739 320373014297 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 320373014298 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 320373014299 EamA-like transporter family; Region: EamA; pfam00892 320373014300 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320373014301 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 320373014302 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 320373014303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320373014304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373014305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373014306 threonine dehydratase; Reviewed; Region: PRK09224 320373014307 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 320373014308 tetramer interface [polypeptide binding]; other site 320373014309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373014310 catalytic residue [active] 320373014311 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 320373014312 putative Ile/Val binding site [chemical binding]; other site 320373014313 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 320373014314 putative Ile/Val binding site [chemical binding]; other site 320373014315 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 320373014316 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 320373014317 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 320373014318 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 320373014319 linker region; other site 320373014320 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373014321 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 320373014322 putative acyl-acceptor binding pocket; other site 320373014323 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 320373014324 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 320373014325 putative active site [active] 320373014326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320373014327 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 320373014328 Walker A/P-loop; other site 320373014329 ATP binding site [chemical binding]; other site 320373014330 Q-loop/lid; other site 320373014331 ABC transporter signature motif; other site 320373014332 Walker B; other site 320373014333 D-loop; other site 320373014334 H-loop/switch region; other site 320373014335 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 320373014336 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 320373014337 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 320373014338 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 320373014339 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 320373014340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 320373014341 ATP binding site [chemical binding]; other site 320373014342 putative Mg++ binding site [ion binding]; other site 320373014343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 320373014344 nucleotide binding region [chemical binding]; other site 320373014345 ATP-binding site [chemical binding]; other site 320373014346 DEAD/H associated; Region: DEAD_assoc; pfam08494 320373014347 putative transporter; Provisional; Region: PRK11021 320373014348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 320373014349 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 320373014350 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 320373014351 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 320373014352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373014353 S-adenosylmethionine binding site [chemical binding]; other site 320373014354 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320373014355 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373014356 metal binding site [ion binding]; metal-binding site 320373014357 active site 320373014358 I-site; other site 320373014359 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 320373014360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373014361 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373014362 dimerization interface [polypeptide binding]; other site 320373014363 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 320373014364 heterodimer interface [polypeptide binding]; other site 320373014365 multimer interface [polypeptide binding]; other site 320373014366 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 320373014367 active site 320373014368 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 320373014369 active site 320373014370 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 320373014371 SxDxEG motif; other site 320373014372 active site 320373014373 metal binding site [ion binding]; metal-binding site 320373014374 homopentamer interface [polypeptide binding]; other site 320373014375 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 320373014376 active site pocket [active] 320373014377 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 320373014378 cleavage site 320373014379 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 320373014380 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 320373014381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373014382 dimer interface [polypeptide binding]; other site 320373014383 conserved gate region; other site 320373014384 putative PBP binding loops; other site 320373014385 ABC-ATPase subunit interface; other site 320373014386 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 320373014387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373014388 dimer interface [polypeptide binding]; other site 320373014389 conserved gate region; other site 320373014390 putative PBP binding loops; other site 320373014391 ABC-ATPase subunit interface; other site 320373014392 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 320373014393 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 320373014394 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 320373014395 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373014396 Walker A/P-loop; other site 320373014397 ATP binding site [chemical binding]; other site 320373014398 Q-loop/lid; other site 320373014399 ABC transporter signature motif; other site 320373014400 Walker B; other site 320373014401 D-loop; other site 320373014402 H-loop/switch region; other site 320373014403 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 320373014404 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373014405 Walker A/P-loop; other site 320373014406 ATP binding site [chemical binding]; other site 320373014407 Q-loop/lid; other site 320373014408 ABC transporter signature motif; other site 320373014409 Walker B; other site 320373014410 D-loop; other site 320373014411 H-loop/switch region; other site 320373014412 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320373014413 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 320373014414 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 320373014415 catalytic nucleophile [active] 320373014416 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 320373014417 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 320373014418 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 320373014419 putative active site [active] 320373014420 BCCT family transporter; Region: BCCT; pfam02028 320373014421 Beta-lactamase; Region: Beta-lactamase; pfam00144 320373014422 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 320373014423 Phosphoesterase family; Region: Phosphoesterase; pfam04185 320373014424 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 320373014425 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320373014426 active site 320373014427 HIGH motif; other site 320373014428 nucleotide binding site [chemical binding]; other site 320373014429 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 320373014430 active site 320373014431 KMSKS motif; other site 320373014432 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 320373014433 tRNA binding surface [nucleotide binding]; other site 320373014434 anticodon binding site; other site 320373014435 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 320373014436 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320373014437 EamA-like transporter family; Region: EamA; pfam00892 320373014438 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 320373014439 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 320373014440 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 320373014441 FAD binding domain; Region: FAD_binding_4; pfam01565 320373014442 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 320373014443 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320373014444 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373014445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373014446 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 320373014447 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 320373014448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373014449 catalytic residue [active] 320373014450 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 320373014451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373014452 putative DNA binding site [nucleotide binding]; other site 320373014453 putative Zn2+ binding site [ion binding]; other site 320373014454 AsnC family; Region: AsnC_trans_reg; pfam01037 320373014455 LabA_like proteins; Region: LabA_like; cd06167 320373014456 putative metal binding site [ion binding]; other site 320373014457 Uncharacterized conserved protein [Function unknown]; Region: COG1432 320373014458 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 320373014459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014460 putative substrate translocation pore; other site 320373014461 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 320373014462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373014463 DNA-binding site [nucleotide binding]; DNA binding site 320373014464 UTRA domain; Region: UTRA; pfam07702 320373014465 benzoate transport; Region: 2A0115; TIGR00895 320373014466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014467 putative substrate translocation pore; other site 320373014468 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 320373014469 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 320373014470 active site 320373014471 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320373014472 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320373014473 active site 320373014474 metal binding site [ion binding]; metal-binding site 320373014475 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 320373014476 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 320373014477 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 320373014478 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 320373014479 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 320373014480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373014481 Coenzyme A binding pocket [chemical binding]; other site 320373014482 Predicted transporter component [General function prediction only]; Region: COG2391 320373014483 Sulphur transport; Region: Sulf_transp; pfam04143 320373014484 Predicted transporter component [General function prediction only]; Region: COG2391 320373014485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373014486 dimerization interface [polypeptide binding]; other site 320373014487 putative DNA binding site [nucleotide binding]; other site 320373014488 putative Zn2+ binding site [ion binding]; other site 320373014489 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 320373014490 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 320373014491 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 320373014492 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373014493 catalytic residue [active] 320373014494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373014495 non-specific DNA binding site [nucleotide binding]; other site 320373014496 salt bridge; other site 320373014497 sequence-specific DNA binding site [nucleotide binding]; other site 320373014498 serine O-acetyltransferase; Region: cysE; TIGR01172 320373014499 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 320373014500 trimer interface [polypeptide binding]; other site 320373014501 active site 320373014502 substrate binding site [chemical binding]; other site 320373014503 CoA binding site [chemical binding]; other site 320373014504 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 320373014505 active site residue [active] 320373014506 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 320373014507 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 320373014508 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 320373014509 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373014510 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373014511 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373014512 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 320373014513 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 320373014514 Ligand binding site; other site 320373014515 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 320373014516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014517 putative substrate translocation pore; other site 320373014518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014519 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 320373014520 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 320373014521 active site 320373014522 TDP-binding site; other site 320373014523 acceptor substrate-binding pocket; other site 320373014524 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320373014525 transcriptional regulator BetI; Validated; Region: PRK00767 320373014526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373014527 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 320373014528 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 320373014529 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 320373014530 NAD(P) binding site [chemical binding]; other site 320373014531 catalytic residues [active] 320373014532 choline dehydrogenase; Validated; Region: PRK02106 320373014533 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320373014534 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 320373014535 benzoate transport; Region: 2A0115; TIGR00895 320373014536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014537 putative substrate translocation pore; other site 320373014538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014539 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 320373014540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373014541 active site 320373014542 phosphorylation site [posttranslational modification] 320373014543 intermolecular recognition site; other site 320373014544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373014545 PAS fold; Region: PAS_3; pfam08447 320373014546 putative active site [active] 320373014547 heme pocket [chemical binding]; other site 320373014548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 320373014549 Histidine kinase; Region: HisKA_3; pfam07730 320373014550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373014551 ATP binding site [chemical binding]; other site 320373014552 Mg2+ binding site [ion binding]; other site 320373014553 G-X-G motif; other site 320373014554 Response regulator receiver domain; Region: Response_reg; pfam00072 320373014555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373014556 active site 320373014557 phosphorylation site [posttranslational modification] 320373014558 intermolecular recognition site; other site 320373014559 dimerization interface [polypeptide binding]; other site 320373014560 CHASE3 domain; Region: CHASE3; pfam05227 320373014561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373014562 PAS domain; Region: PAS_9; pfam13426 320373014563 putative active site [active] 320373014564 heme pocket [chemical binding]; other site 320373014565 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 320373014566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373014567 putative active site [active] 320373014568 heme pocket [chemical binding]; other site 320373014569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373014570 dimer interface [polypeptide binding]; other site 320373014571 phosphorylation site [posttranslational modification] 320373014572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373014573 ATP binding site [chemical binding]; other site 320373014574 Mg2+ binding site [ion binding]; other site 320373014575 G-X-G motif; other site 320373014576 OsmC-like protein; Region: OsmC; cl00767 320373014577 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 320373014578 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 320373014579 putative ligand binding site [chemical binding]; other site 320373014580 NAD binding site [chemical binding]; other site 320373014581 catalytic site [active] 320373014582 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 320373014583 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 320373014584 DNA-binding site [nucleotide binding]; DNA binding site 320373014585 RNA-binding motif; other site 320373014586 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 320373014587 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 320373014588 active site 320373014589 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 320373014590 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 320373014591 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 320373014592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373014593 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 320373014594 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 320373014595 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 320373014596 hydroxyglutarate oxidase; Provisional; Region: PRK11728 320373014597 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 320373014598 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 320373014599 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 320373014600 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320373014601 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 320373014602 conserved cys residue [active] 320373014603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373014604 hypothetical protein; Provisional; Region: PRK11239 320373014605 Protein of unknown function, DUF480; Region: DUF480; pfam04337 320373014606 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 320373014607 GSH binding site (G-site) [chemical binding]; other site 320373014608 C-terminal domain interface [polypeptide binding]; other site 320373014609 dimer interface [polypeptide binding]; other site 320373014610 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 320373014611 dimer interface [polypeptide binding]; other site 320373014612 N-terminal domain interface [polypeptide binding]; other site 320373014613 substrate binding pocket (H-site) [chemical binding]; other site 320373014614 Low affinity iron permease; Region: Iron_permease; pfam04120 320373014615 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 320373014616 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 320373014617 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 320373014618 Domain of unknown function (DUF305); Region: DUF305; pfam03713 320373014619 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 320373014620 MgtC family; Region: MgtC; pfam02308 320373014621 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 320373014622 putative active site [active] 320373014623 catalytic site [active] 320373014624 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 320373014625 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 320373014626 putative active site [active] 320373014627 catalytic site [active] 320373014628 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 320373014629 Uncharacterized conserved protein [Function unknown]; Region: COG0398 320373014630 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 320373014631 putative catalytic site [active] 320373014632 putative metal binding site [ion binding]; other site 320373014633 putative phosphate binding site [ion binding]; other site 320373014634 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 320373014635 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 320373014636 type II secretion system protein D; Region: type_II_gspD; TIGR02517 320373014637 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373014638 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373014639 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373014640 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373014641 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 320373014642 type III secretion protein HrpB7; Region: HrpB7; TIGR02559 320373014643 type III secretion system ATPase; Provisional; Region: PRK09099 320373014644 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320373014645 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320373014646 Walker A motif; other site 320373014647 ATP binding site [chemical binding]; other site 320373014648 Walker B motif; other site 320373014649 type III secretion system protein HrpB; Validated; Region: PRK09098 320373014650 Flagellar assembly protein FliH; Region: FliH; pfam02108 320373014651 type III secretion protein HrpB4; Region: HrpB4; TIGR02560 320373014652 Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502 320373014653 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 320373014654 type III secretion protein HrpB2; Region: HrpB2; TIGR02558 320373014655 type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561 320373014656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 320373014657 TPR motif; other site 320373014658 binding surface 320373014659 type III secretion system protein HrcU; Validated; Region: PRK09108 320373014660 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 320373014661 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 320373014662 FHIPEP family; Region: FHIPEP; pfam00771 320373014663 type III secretion protein HpaP; Region: HpaP; TIGR02557 320373014664 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 320373014665 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 320373014666 type III secretion system protein YscR; Provisional; Region: PRK12797 320373014667 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 320373014668 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 320373014669 Tir chaperone protein (CesT) family; Region: CesT; cl08444 320373014670 Cupin domain; Region: Cupin_2; cl17218 320373014671 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 320373014672 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 320373014673 Transcriptional regulators [Transcription]; Region: FadR; COG2186 320373014674 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373014675 DNA-binding site [nucleotide binding]; DNA binding site 320373014676 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 320373014677 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 320373014678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 320373014679 putative aldolase; Validated; Region: PRK08130 320373014680 intersubunit interface [polypeptide binding]; other site 320373014681 active site 320373014682 Zn2+ binding site [ion binding]; other site 320373014683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014684 D-galactonate transporter; Region: 2A0114; TIGR00893 320373014685 putative substrate translocation pore; other site 320373014686 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 320373014687 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320373014688 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 320373014689 putative NAD(P) binding site [chemical binding]; other site 320373014690 active site 320373014691 putative substrate binding site [chemical binding]; other site 320373014692 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 320373014693 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 320373014694 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 320373014695 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 320373014696 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320373014697 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 320373014698 conserved cys residue [active] 320373014699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373014700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373014701 dimer interface [polypeptide binding]; other site 320373014702 conserved gate region; other site 320373014703 putative PBP binding loops; other site 320373014704 ABC-ATPase subunit interface; other site 320373014705 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 320373014706 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 320373014707 Walker A/P-loop; other site 320373014708 ATP binding site [chemical binding]; other site 320373014709 Q-loop/lid; other site 320373014710 ABC transporter signature motif; other site 320373014711 Walker B; other site 320373014712 D-loop; other site 320373014713 H-loop/switch region; other site 320373014714 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 320373014715 Predicted flavoprotein [General function prediction only]; Region: COG0431 320373014716 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320373014717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373014718 dimerization interface [polypeptide binding]; other site 320373014719 putative DNA binding site [nucleotide binding]; other site 320373014720 putative Zn2+ binding site [ion binding]; other site 320373014721 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 320373014722 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373014723 putative metal binding site [ion binding]; other site 320373014724 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 320373014725 Low molecular weight phosphatase family; Region: LMWPc; cd00115 320373014726 active site 320373014727 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 320373014728 arsenical-resistance protein; Region: acr3; TIGR00832 320373014729 ribonuclease E; Reviewed; Region: rne; PRK10811 320373014730 ribonuclease E; Reviewed; Region: rne; PRK10811 320373014731 ribonuclease E; Reviewed; Region: rne; PRK10811 320373014732 ribonuclease E; Reviewed; Region: rne; PRK10811 320373014733 ribonuclease E; Reviewed; Region: rne; PRK10811 320373014734 Haemagglutinin; Region: HIM; pfam05662 320373014735 YadA-like C-terminal region; Region: YadA; pfam03895 320373014736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373014737 binding surface 320373014738 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373014739 Haemagglutinin; Region: HIM; pfam05662 320373014740 YadA-like C-terminal region; Region: YadA; pfam03895 320373014741 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 320373014742 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 320373014743 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 320373014744 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 320373014745 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320373014746 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320373014747 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 320373014748 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 320373014749 carboxyltransferase (CT) interaction site; other site 320373014750 biotinylation site [posttranslational modification]; other site 320373014751 enoyl-CoA hydratase; Provisional; Region: PRK05995 320373014752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373014753 substrate binding site [chemical binding]; other site 320373014754 oxyanion hole (OAH) forming residues; other site 320373014755 trimer interface [polypeptide binding]; other site 320373014756 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 320373014757 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 320373014758 isovaleryl-CoA dehydrogenase; Region: PLN02519 320373014759 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 320373014760 substrate binding site [chemical binding]; other site 320373014761 FAD binding site [chemical binding]; other site 320373014762 catalytic base [active] 320373014763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373014764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373014765 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 320373014766 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 320373014767 putative active site [active] 320373014768 homotrimer interaction site [polypeptide binding]; other site 320373014769 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 320373014770 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 320373014771 Putative water exit pathway; other site 320373014772 Binuclear center (active site) [active] 320373014773 K-pathway; other site 320373014774 Putative proton exit pathway; other site 320373014775 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 320373014776 Multicopper oxidase; Region: Cu-oxidase; pfam00394 320373014777 Cytochrome c; Region: Cytochrom_C; pfam00034 320373014778 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320373014779 [2Fe-2S] cluster binding site [ion binding]; other site 320373014780 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 320373014781 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 320373014782 alpha subunit interface [polypeptide binding]; other site 320373014783 active site 320373014784 substrate binding site [chemical binding]; other site 320373014785 Fe binding site [ion binding]; other site 320373014786 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 320373014787 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 320373014788 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 320373014789 catalytic residue [active] 320373014790 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 320373014791 Cupin-like domain; Region: Cupin_8; pfam13621 320373014792 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 320373014793 benzoate transport; Region: 2A0115; TIGR00895 320373014794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014796 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 320373014797 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320373014798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373014799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373014800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 320373014801 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 320373014802 dimer interface [polypeptide binding]; other site 320373014803 phosphorylation site [posttranslational modification] 320373014804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373014805 ATP binding site [chemical binding]; other site 320373014806 Mg2+ binding site [ion binding]; other site 320373014807 G-X-G motif; other site 320373014808 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373014809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373014810 active site 320373014811 phosphorylation site [posttranslational modification] 320373014812 intermolecular recognition site; other site 320373014813 dimerization interface [polypeptide binding]; other site 320373014814 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373014815 DNA binding site [nucleotide binding] 320373014816 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 320373014817 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 320373014818 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 320373014819 Flavodoxin; Region: Flavodoxin_1; pfam00258 320373014820 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 320373014821 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 320373014822 FAD binding pocket [chemical binding]; other site 320373014823 conserved FAD binding motif [chemical binding]; other site 320373014824 phosphate binding motif [ion binding]; other site 320373014825 beta-alpha-beta structure motif; other site 320373014826 NAD binding pocket [chemical binding]; other site 320373014827 ApbE family; Region: ApbE; pfam02424 320373014828 ApbE family; Region: ApbE; pfam02424 320373014829 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 320373014830 aldehyde dehydrogenase family 7 member; Region: PLN02315 320373014831 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 320373014832 tetrameric interface [polypeptide binding]; other site 320373014833 NAD binding site [chemical binding]; other site 320373014834 catalytic residues [active] 320373014835 aminotransferase A; Validated; Region: PRK07683 320373014836 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373014837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373014838 homodimer interface [polypeptide binding]; other site 320373014839 catalytic residue [active] 320373014840 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 320373014841 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320373014842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373014843 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373014844 dimerization interface [polypeptide binding]; other site 320373014845 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 320373014846 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 320373014847 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 320373014848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373014849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373014850 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 320373014851 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 320373014852 putative active site [active] 320373014853 catalytic site [active] 320373014854 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 320373014855 putative active site [active] 320373014856 catalytic site [active] 320373014857 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 320373014858 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 320373014859 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 320373014860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014861 D-galactonate transporter; Region: 2A0114; TIGR00893 320373014862 putative substrate translocation pore; other site 320373014863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373014864 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 320373014865 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 320373014866 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 320373014867 Transcriptional regulators [Transcription]; Region: GntR; COG1802 320373014868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373014869 DNA-binding site [nucleotide binding]; DNA binding site 320373014870 FCD domain; Region: FCD; pfam07729 320373014871 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 320373014872 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 320373014873 putative active site pocket [active] 320373014874 putative metal binding site [ion binding]; other site 320373014875 putative oxidoreductase; Provisional; Region: PRK10083 320373014876 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 320373014877 putative NAD(P) binding site [chemical binding]; other site 320373014878 catalytic Zn binding site [ion binding]; other site 320373014879 structural Zn binding site [ion binding]; other site 320373014880 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 320373014881 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 320373014882 homodimer interface [polypeptide binding]; other site 320373014883 NAD binding pocket [chemical binding]; other site 320373014884 ATP binding pocket [chemical binding]; other site 320373014885 Mg binding site [ion binding]; other site 320373014886 active-site loop [active] 320373014887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373014888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373014889 hypothetical protein; Provisional; Region: PRK02399 320373014890 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 320373014891 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 320373014892 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 320373014893 putative hydrophobic ligand binding site [chemical binding]; other site 320373014894 protein interface [polypeptide binding]; other site 320373014895 gate; other site 320373014896 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 320373014897 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 320373014898 Multicopper oxidase; Region: Cu-oxidase; pfam00394 320373014899 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373014900 Cytochrome c; Region: Cytochrom_C; pfam00034 320373014901 Uncharacterized conserved protein [Function unknown]; Region: COG1262 320373014902 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 320373014903 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 320373014904 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320373014905 Cu(I) binding site [ion binding]; other site 320373014906 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 320373014907 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 320373014908 amidase catalytic site [active] 320373014909 Zn binding residues [ion binding]; other site 320373014910 substrate binding site [chemical binding]; other site 320373014911 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 320373014912 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373014913 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 320373014914 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 320373014915 trimer interface [polypeptide binding]; other site 320373014916 Haemagglutinin; Region: HIM; pfam05662 320373014917 YadA-like C-terminal region; Region: YadA; pfam03895 320373014918 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320373014919 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 320373014920 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373014921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373014922 active site 320373014923 phosphorylation site [posttranslational modification] 320373014924 intermolecular recognition site; other site 320373014925 dimerization interface [polypeptide binding]; other site 320373014926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373014927 DNA binding site [nucleotide binding] 320373014928 MASE1; Region: MASE1; cl17823 320373014929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373014930 dimer interface [polypeptide binding]; other site 320373014931 phosphorylation site [posttranslational modification] 320373014932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373014933 ATP binding site [chemical binding]; other site 320373014934 G-X-G motif; other site 320373014935 Protein of unknown function (DUF770); Region: DUF770; pfam05591 320373014936 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 320373014937 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320373014938 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 320373014939 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 320373014940 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 320373014941 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320373014942 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 320373014943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373014944 Walker A motif; other site 320373014945 ATP binding site [chemical binding]; other site 320373014946 Walker B motif; other site 320373014947 arginine finger; other site 320373014948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373014949 Walker A motif; other site 320373014950 ATP binding site [chemical binding]; other site 320373014951 Walker B motif; other site 320373014952 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320373014953 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 320373014954 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373014955 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373014956 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 320373014957 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320373014958 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373014959 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373014960 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320373014961 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320373014962 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373014963 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 320373014964 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 320373014965 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 320373014966 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 320373014967 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 320373014968 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 320373014969 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 320373014970 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320373014971 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 320373014972 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 320373014973 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320373014974 Bacterial Ig-like domain; Region: Big_5; pfam13205 320373014975 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 320373014976 active site 320373014977 GTP cyclohydrolase I; Reviewed; Region: PRK12606 320373014978 GTP cyclohydrolase I; Provisional; Region: PLN03044 320373014979 active site 320373014980 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373014981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373014982 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373014983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373014984 active site 320373014985 phosphorylation site [posttranslational modification] 320373014986 intermolecular recognition site; other site 320373014987 dimerization interface [polypeptide binding]; other site 320373014988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373014989 DNA binding residues [nucleotide binding] 320373014990 dimerization interface [polypeptide binding]; other site 320373014991 chaperone protein SicP; Provisional; Region: PRK15329 320373014992 SicP binding; Region: SicP-binding; pfam09119 320373014993 type III secretion protein BopE; Provisional; Region: PRK15278 320373014994 SopE GEF domain; Region: SopE_GEF; pfam07487 320373014995 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 320373014996 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 320373014997 N-acetyl-D-glucosamine binding site [chemical binding]; other site 320373014998 catalytic residue [active] 320373014999 Phosphopantetheine attachment site; Region: PP-binding; cl09936 320373015000 type III effector protein IpaD/SipD/SspD; Region: SipD_IpaD_SspD; TIGR02553 320373015001 H-NS histone family; Region: Histone_HNS; pfam00816 320373015002 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373015003 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; pfam09599 320373015004 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 320373015005 chaperone protein SicA; Provisional; Region: PRK15331 320373015006 Tetratricopeptide repeat; Region: TPR_3; pfam07720 320373015007 Tetratricopeptide repeat; Region: TPR_3; pfam07720 320373015008 type III secretion system protein SpaS; Validated; Region: PRK08156 320373015009 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 320373015010 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 320373015011 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 320373015012 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 320373015013 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 320373015014 ATP synthase SpaL; Validated; Region: PRK08149 320373015015 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320373015016 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320373015017 Walker A motif; other site 320373015018 ATP binding site [chemical binding]; other site 320373015019 Walker B motif; other site 320373015020 Invasion protein B family; Region: Invas_SpaK; cl04129 320373015021 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 320373015022 type III secretion system protein InvA; Provisional; Region: PRK15337 320373015023 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 320373015024 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373015025 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373015026 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 320373015027 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373015028 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373015029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373015030 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 320373015031 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 320373015032 Type III secretion needle MxiH like; Region: MxiH; cl09641 320373015033 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 320373015034 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 320373015035 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 320373015036 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 320373015037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 320373015038 DNA binding site [nucleotide binding] 320373015039 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 320373015040 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 320373015041 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 320373015042 active site 320373015043 Zn binding site [ion binding]; other site 320373015044 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320373015045 MarR family; Region: MarR_2; cl17246 320373015046 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 320373015047 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373015048 dimer interface [polypeptide binding]; other site 320373015049 putative metal binding site [ion binding]; other site 320373015050 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 320373015051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373015052 putative substrate translocation pore; other site 320373015053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373015054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373015055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373015056 dimerization interface [polypeptide binding]; other site 320373015057 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 320373015058 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 320373015059 phosphate binding site [ion binding]; other site 320373015060 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 320373015061 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 320373015062 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 320373015063 peptidase domain interface [polypeptide binding]; other site 320373015064 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 320373015065 active site 320373015066 catalytic triad [active] 320373015067 calcium binding site [ion binding]; other site 320373015068 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373015069 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373015070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373015071 putative DNA binding site [nucleotide binding]; other site 320373015072 putative Zn2+ binding site [ion binding]; other site 320373015073 AsnC family; Region: AsnC_trans_reg; pfam01037 320373015074 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 320373015075 putative hydrophobic ligand binding site [chemical binding]; other site 320373015076 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 320373015077 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 320373015078 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 320373015079 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 320373015080 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373015081 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 320373015082 putative AMP binding site [chemical binding]; other site 320373015083 putative active site [active] 320373015084 acyl-activating enzyme (AAE) consensus motif; other site 320373015085 putative CoA binding site [chemical binding]; other site 320373015086 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320373015087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373015088 DNA binding residues [nucleotide binding] 320373015089 dimerization interface [polypeptide binding]; other site 320373015090 Autoinducer synthetase; Region: Autoind_synth; cl17404 320373015091 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 320373015092 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320373015093 putative active site [active] 320373015094 putative FMN binding site [chemical binding]; other site 320373015095 putative substrate binding site [chemical binding]; other site 320373015096 putative catalytic residue [active] 320373015097 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 320373015098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373015099 dimer interface [polypeptide binding]; other site 320373015100 conserved gate region; other site 320373015101 putative PBP binding loops; other site 320373015102 ABC-ATPase subunit interface; other site 320373015103 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 320373015104 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 320373015105 Walker A/P-loop; other site 320373015106 ATP binding site [chemical binding]; other site 320373015107 Q-loop/lid; other site 320373015108 ABC transporter signature motif; other site 320373015109 Walker B; other site 320373015110 D-loop; other site 320373015111 H-loop/switch region; other site 320373015112 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 320373015113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373015114 substrate binding pocket [chemical binding]; other site 320373015115 membrane-bound complex binding site; other site 320373015116 hinge residues; other site 320373015117 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 320373015118 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 320373015119 active site 320373015120 iron coordination sites [ion binding]; other site 320373015121 substrate binding pocket [chemical binding]; other site 320373015122 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 320373015123 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 320373015124 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 320373015125 DXD motif; other site 320373015126 PilZ domain; Region: PilZ; pfam07238 320373015127 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 320373015128 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 320373015129 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 320373015130 endo-1,4-D-glucanase; Provisional; Region: PRK11097 320373015131 cellulose synthase regulator protein; Provisional; Region: PRK11114 320373015132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373015133 non-specific DNA binding site [nucleotide binding]; other site 320373015134 salt bridge; other site 320373015135 sequence-specific DNA binding site [nucleotide binding]; other site 320373015136 HipA N-terminal domain; Region: couple_hipA; TIGR03071 320373015137 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 320373015138 HipA-like N-terminal domain; Region: HipA_N; pfam07805 320373015139 HipA-like C-terminal domain; Region: HipA_C; pfam07804 320373015140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373015141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373015142 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 320373015143 dimerization interface [polypeptide binding]; other site 320373015144 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 320373015145 agmatinase; Region: agmatinase; TIGR01230 320373015146 oligomer interface [polypeptide binding]; other site 320373015147 putative active site [active] 320373015148 Mn binding site [ion binding]; other site 320373015149 type II secretion system protein D; Region: type_II_gspD; TIGR02517 320373015150 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373015151 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 320373015152 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373015153 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 320373015154 PilM; Region: PilM; pfam07419 320373015155 PilS N terminal; Region: PilS; pfam08805 320373015156 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373015157 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373015158 Type II/IV secretion system protein; Region: T2SE; pfam00437 320373015159 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320373015160 Walker A motif; other site 320373015161 ATP binding site [chemical binding]; other site 320373015162 Walker B motif; other site 320373015163 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 320373015164 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 320373015165 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373015166 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 320373015167 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320373015168 Walker A motif; other site 320373015169 ATP binding site [chemical binding]; other site 320373015170 Walker B motif; other site 320373015171 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 320373015172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 320373015173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373015174 active site 320373015175 phosphorylation site [posttranslational modification] 320373015176 intermolecular recognition site; other site 320373015177 dimerization interface [polypeptide binding]; other site 320373015178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373015179 DNA binding site [nucleotide binding] 320373015180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373015181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373015182 ATP binding site [chemical binding]; other site 320373015183 Mg2+ binding site [ion binding]; other site 320373015184 G-X-G motif; other site 320373015185 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 320373015186 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 320373015187 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373015188 Tir chaperone protein (CesT) family; Region: CesT; cl08444 320373015189 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 320373015190 type III secretion system protein YscR; Provisional; Region: PRK12797 320373015191 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 320373015192 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 320373015193 type III secretion protein HpaP; Region: HpaP; TIGR02557 320373015194 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 320373015195 FHIPEP family; Region: FHIPEP; pfam00771 320373015196 type III secretion system protein HrcU; Validated; Region: PRK09108 320373015197 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 320373015198 type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561 320373015199 type III secretion protein HrpB2; Region: HrpB2; TIGR02558 320373015200 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 320373015201 type III secretion protein HrpB4; Region: HrpB4; TIGR02560 320373015202 Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502 320373015203 type III secretion system protein HrpB; Validated; Region: PRK09098 320373015204 Flagellar assembly protein FliH; Region: FliH; pfam02108 320373015205 type III secretion system ATPase; Provisional; Region: PRK09099 320373015206 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320373015207 Walker A motif; other site 320373015208 ATP binding site [chemical binding]; other site 320373015209 Walker B motif; other site 320373015210 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 320373015211 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 320373015212 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 320373015213 substrate binding pocket [chemical binding]; other site 320373015214 active site 320373015215 iron coordination sites [ion binding]; other site 320373015216 Condensation domain; Region: Condensation; pfam00668 320373015217 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373015218 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373015219 acyl-activating enzyme (AAE) consensus motif; other site 320373015220 AMP binding site [chemical binding]; other site 320373015221 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373015222 Condensation domain; Region: Condensation; pfam00668 320373015223 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373015224 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373015225 acyl-activating enzyme (AAE) consensus motif; other site 320373015226 AMP binding site [chemical binding]; other site 320373015227 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373015228 Condensation domain; Region: Condensation; pfam00668 320373015229 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373015230 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373015231 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373015232 acyl-activating enzyme (AAE) consensus motif; other site 320373015233 AMP binding site [chemical binding]; other site 320373015234 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373015235 Condensation domain; Region: Condensation; pfam00668 320373015236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373015237 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373015238 acyl-activating enzyme (AAE) consensus motif; other site 320373015239 AMP binding site [chemical binding]; other site 320373015240 active site 320373015241 CoA binding site [chemical binding]; other site 320373015242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373015243 Condensation domain; Region: Condensation; pfam00668 320373015244 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 320373015245 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 320373015246 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 320373015247 acyl-activating enzyme (AAE) consensus motif; other site 320373015248 AMP binding site [chemical binding]; other site 320373015249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373015250 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 320373015251 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 320373015252 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 320373015253 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373015254 inhibitor-cofactor binding pocket; inhibition site 320373015255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373015256 catalytic residue [active] 320373015257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373015258 putative substrate translocation pore; other site 320373015259 pyruvate dehydrogenase; Provisional; Region: PRK09124 320373015260 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 320373015261 PYR/PP interface [polypeptide binding]; other site 320373015262 tetramer interface [polypeptide binding]; other site 320373015263 dimer interface [polypeptide binding]; other site 320373015264 TPP binding site [chemical binding]; other site 320373015265 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373015266 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 320373015267 TPP-binding site [chemical binding]; other site 320373015268 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 320373015269 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 320373015270 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 320373015271 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 320373015272 putative active site [active] 320373015273 putative catalytic site [active] 320373015274 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 320373015275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373015276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373015277 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 320373015278 putative dimerization interface [polypeptide binding]; other site 320373015279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373015280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373015281 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373015282 putative effector binding pocket; other site 320373015283 dimerization interface [polypeptide binding]; other site 320373015284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373015285 putative substrate translocation pore; other site 320373015286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 320373015287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373015288 ATP binding site [chemical binding]; other site 320373015289 Mg2+ binding site [ion binding]; other site 320373015290 G-X-G motif; other site 320373015291 Uncharacterized conserved protein [Function unknown]; Region: COG3287 320373015292 FIST N domain; Region: FIST; pfam08495 320373015293 FIST C domain; Region: FIST_C; pfam10442 320373015294 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 320373015295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373015296 active site 320373015297 phosphorylation site [posttranslational modification] 320373015298 intermolecular recognition site; other site 320373015299 dimerization interface [polypeptide binding]; other site 320373015300 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 320373015301 Zn2+ binding site [ion binding]; other site 320373015302 Mg2+ binding site [ion binding]; other site 320373015303 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 320373015304 Ricin-type beta-trefoil; Region: RICIN; smart00458 320373015305 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 320373015306 putative sugar binding sites [chemical binding]; other site 320373015307 Q-X-W motif; other site 320373015308 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 320373015309 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 320373015310 putative sugar binding sites [chemical binding]; other site 320373015311 Q-X-W motif; other site 320373015312 Kelch motif; Region: Kelch_6; pfam13964 320373015313 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 320373015314 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 320373015315 Cu(I) binding site [ion binding]; other site 320373015316 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 320373015317 active site 320373015318 nucleophile elbow; other site 320373015319 benzoate transport; Region: 2A0115; TIGR00895 320373015320 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 320373015321 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 320373015322 Cytochrome P450; Region: p450; cl12078 320373015323 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 320373015324 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 320373015325 FMN-binding pocket [chemical binding]; other site 320373015326 flavin binding motif; other site 320373015327 phosphate binding motif [ion binding]; other site 320373015328 beta-alpha-beta structure motif; other site 320373015329 NAD binding pocket [chemical binding]; other site 320373015330 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373015331 catalytic loop [active] 320373015332 iron binding site [ion binding]; other site 320373015333 H+ Antiporter protein; Region: 2A0121; TIGR00900 320373015334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373015335 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 320373015336 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 320373015337 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 320373015338 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 320373015339 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 320373015340 Amidase; Region: Amidase; pfam01425 320373015341 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 320373015342 catalytic residue [active] 320373015343 Phage T7 tail fibre protein; Region: Phage_T7_tail; pfam03906 320373015344 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 320373015345 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 320373015346 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 320373015347 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 320373015348 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 320373015349 Terminase-like family; Region: Terminase_6; pfam03237 320373015350 hypothetical protein; Region: PHA01971 320373015351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373015352 non-specific DNA binding site [nucleotide binding]; other site 320373015353 salt bridge; other site 320373015354 Predicted transcriptional regulator [Transcription]; Region: COG2932 320373015355 sequence-specific DNA binding site [nucleotide binding]; other site 320373015356 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 320373015357 Catalytic site [active] 320373015358 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 320373015359 KTSC domain; Region: KTSC; pfam13619 320373015360 RecT family; Region: RecT; pfam03837 320373015361 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 320373015362 DNA methylase; Region: N6_N4_Mtase; pfam01555 320373015363 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 320373015364 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 320373015365 active site 320373015366 Int/Topo IB signature motif; other site 320373015367 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 320373015368 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 320373015369 G1 box; other site 320373015370 putative GEF interaction site [polypeptide binding]; other site 320373015371 GTP/Mg2+ binding site [chemical binding]; other site 320373015372 Switch I region; other site 320373015373 G2 box; other site 320373015374 G3 box; other site 320373015375 Switch II region; other site 320373015376 G4 box; other site 320373015377 G5 box; other site 320373015378 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 320373015379 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 320373015380 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 320373015381 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 320373015382 selenocysteine synthase; Provisional; Region: PRK04311 320373015383 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 320373015384 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373015385 catalytic residue [active] 320373015386 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 320373015387 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 320373015388 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 320373015389 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 320373015390 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 320373015391 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 320373015392 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373015393 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373015394 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 320373015395 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 320373015396 molybdopterin cofactor binding site; other site 320373015397 Uncharacterized conserved protein [Function unknown]; Region: COG1434 320373015398 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 320373015399 putative active site [active] 320373015400 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373015401 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320373015402 substrate binding pocket [chemical binding]; other site 320373015403 membrane-bound complex binding site; other site 320373015404 hinge residues; other site 320373015405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373015406 dimer interface [polypeptide binding]; other site 320373015407 conserved gate region; other site 320373015408 putative PBP binding loops; other site 320373015409 ABC-ATPase subunit interface; other site 320373015410 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 320373015411 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320373015412 Walker A/P-loop; other site 320373015413 ATP binding site [chemical binding]; other site 320373015414 Q-loop/lid; other site 320373015415 ABC transporter signature motif; other site 320373015416 Walker B; other site 320373015417 D-loop; other site 320373015418 H-loop/switch region; other site 320373015419 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 320373015420 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 320373015421 active site 320373015422 non-prolyl cis peptide bond; other site 320373015423 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 320373015424 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 320373015425 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 320373015426 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373015427 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320373015428 substrate binding pocket [chemical binding]; other site 320373015429 membrane-bound complex binding site; other site 320373015430 hinge residues; other site 320373015431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 320373015432 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 320373015433 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 320373015434 putative active site [active] 320373015435 Zn binding site [ion binding]; other site 320373015436 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 320373015437 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373015438 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373015439 trimer interface [polypeptide binding]; other site 320373015440 eyelet of channel; other site 320373015441 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320373015442 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 320373015443 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 320373015444 active site 320373015445 tetramer interface; other site 320373015446 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320373015447 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373015448 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 320373015449 putative ADP-binding pocket [chemical binding]; other site 320373015450 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 320373015451 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373015452 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 320373015453 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 320373015454 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320373015455 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 320373015456 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 320373015457 NADP-binding site; other site 320373015458 homotetramer interface [polypeptide binding]; other site 320373015459 substrate binding site [chemical binding]; other site 320373015460 homodimer interface [polypeptide binding]; other site 320373015461 active site 320373015462 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320373015463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373015464 NAD(P) binding site [chemical binding]; other site 320373015465 active site 320373015466 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 320373015467 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 320373015468 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 320373015469 homodimer interface [polypeptide binding]; other site 320373015470 substrate-cofactor binding pocket; other site 320373015471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373015472 catalytic residue [active] 320373015473 amidophosphoribosyltransferase; Provisional; Region: PRK09246 320373015474 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 320373015475 active site 320373015476 tetramer interface [polypeptide binding]; other site 320373015477 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 320373015478 active site 320373015479 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 320373015480 Colicin V production protein; Region: Colicin_V; pfam02674 320373015481 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 320373015482 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 320373015483 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 320373015484 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 320373015485 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 320373015486 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 320373015487 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 320373015488 substrate binding site [chemical binding]; other site 320373015489 active site 320373015490 catalytic residues [active] 320373015491 heterodimer interface [polypeptide binding]; other site 320373015492 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 320373015493 DNA methylase; Region: N6_N4_Mtase; pfam01555 320373015494 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 320373015495 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 320373015496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373015497 catalytic residue [active] 320373015498 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 320373015499 active site 320373015500 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 320373015501 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 320373015502 dimerization interface 3.5A [polypeptide binding]; other site 320373015503 active site 320373015504 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 320373015505 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 320373015506 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 320373015507 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 320373015508 tartrate dehydrogenase; Region: TTC; TIGR02089 320373015509 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 320373015510 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 320373015511 substrate binding site [chemical binding]; other site 320373015512 Entericidin EcnA/B family; Region: Entericidin; cl02322 320373015513 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 320373015514 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 320373015515 substrate binding site [chemical binding]; other site 320373015516 ligand binding site [chemical binding]; other site 320373015517 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 320373015518 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 320373015519 active site 320373015520 non-prolyl cis peptide bond; other site 320373015521 cyclase homology domain; Region: CHD; cd07302 320373015522 nucleotidyl binding site; other site 320373015523 metal binding site [ion binding]; metal-binding site 320373015524 dimer interface [polypeptide binding]; other site 320373015525 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373015526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373015527 putative DNA binding site [nucleotide binding]; other site 320373015528 putative Zn2+ binding site [ion binding]; other site 320373015529 AsnC family; Region: AsnC_trans_reg; pfam01037 320373015530 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 320373015531 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 320373015532 dimer interface [polypeptide binding]; other site 320373015533 TPP-binding site [chemical binding]; other site 320373015534 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 320373015535 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 320373015536 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 320373015537 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373015538 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320373015539 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373015540 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 320373015541 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 320373015542 dimer interface [polypeptide binding]; other site 320373015543 active site 320373015544 citrylCoA binding site [chemical binding]; other site 320373015545 NADH binding [chemical binding]; other site 320373015546 cationic pore residues; other site 320373015547 oxalacetate/citrate binding site [chemical binding]; other site 320373015548 coenzyme A binding site [chemical binding]; other site 320373015549 catalytic triad [active] 320373015550 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 320373015551 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 320373015552 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 320373015553 L-aspartate oxidase; Provisional; Region: PRK06175 320373015554 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 320373015555 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 320373015556 SdhC subunit interface [polypeptide binding]; other site 320373015557 proximal heme binding site [chemical binding]; other site 320373015558 cardiolipin binding site; other site 320373015559 Iron-sulfur protein interface; other site 320373015560 proximal quinone binding site [chemical binding]; other site 320373015561 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 320373015562 Iron-sulfur protein interface; other site 320373015563 proximal quinone binding site [chemical binding]; other site 320373015564 SdhD (CybS) interface [polypeptide binding]; other site 320373015565 proximal heme binding site [chemical binding]; other site 320373015566 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 320373015567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373015568 DNA-binding site [nucleotide binding]; DNA binding site 320373015569 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 320373015570 malate dehydrogenase; Provisional; Region: PRK05442 320373015571 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 320373015572 NAD(P) binding site [chemical binding]; other site 320373015573 dimer interface [polypeptide binding]; other site 320373015574 malate binding site [chemical binding]; other site 320373015575 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 320373015576 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 320373015577 2-methylcitrate dehydratase; Region: prpD; TIGR02330 320373015578 aconitate hydratase; Provisional; Region: acnA; PRK12881 320373015579 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 320373015580 substrate binding site [chemical binding]; other site 320373015581 ligand binding site [chemical binding]; other site 320373015582 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 320373015583 substrate binding site [chemical binding]; other site 320373015584 haemagglutination activity domain; Region: Haemagg_act; pfam05860 320373015585 Inositol polyphosphate kinase; Region: IPK; cl12283 320373015586 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 320373015587 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 320373015588 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 320373015589 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373015590 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 320373015591 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 320373015592 Cytochrome c [Energy production and conversion]; Region: COG3258 320373015593 Cytochrome c; Region: Cytochrom_C; pfam00034 320373015594 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 320373015595 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 320373015596 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 320373015597 peptidase domain interface [polypeptide binding]; other site 320373015598 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 320373015599 active site 320373015600 catalytic triad [active] 320373015601 calcium binding site [ion binding]; other site 320373015602 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 320373015603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373015604 putative PBP binding loops; other site 320373015605 dimer interface [polypeptide binding]; other site 320373015606 ABC-ATPase subunit interface; other site 320373015607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373015608 dimer interface [polypeptide binding]; other site 320373015609 conserved gate region; other site 320373015610 putative PBP binding loops; other site 320373015611 ABC-ATPase subunit interface; other site 320373015612 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 320373015613 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 320373015614 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 320373015615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373015616 Walker A/P-loop; other site 320373015617 ATP binding site [chemical binding]; other site 320373015618 Q-loop/lid; other site 320373015619 ABC transporter signature motif; other site 320373015620 Walker B; other site 320373015621 D-loop; other site 320373015622 H-loop/switch region; other site 320373015623 TOBE domain; Region: TOBE_2; pfam08402 320373015624 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 320373015625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373015626 DNA-binding site [nucleotide binding]; DNA binding site 320373015627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373015628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373015629 homodimer interface [polypeptide binding]; other site 320373015630 catalytic residue [active] 320373015631 lipase chaperone; Provisional; Region: PRK01294 320373015632 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 320373015633 Lipase (class 2); Region: Lipase_2; pfam01674 320373015634 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 320373015635 PGAP1-like protein; Region: PGAP1; pfam07819 320373015636 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 320373015637 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373015638 N-terminal plug; other site 320373015639 ligand-binding site [chemical binding]; other site 320373015640 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 320373015641 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 320373015642 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 320373015643 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320373015644 E3 interaction surface; other site 320373015645 lipoyl attachment site [posttranslational modification]; other site 320373015646 Cupin domain; Region: Cupin_2; cl17218 320373015647 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320373015648 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 320373015649 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 320373015650 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 320373015651 Protein of unknown function (DUF938); Region: DUF938; pfam06080 320373015652 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373015653 NAD-dependent deacetylase; Provisional; Region: PRK05333 320373015654 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 320373015655 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 320373015656 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 320373015657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373015658 S-adenosylmethionine binding site [chemical binding]; other site 320373015659 Methyltransferase domain; Region: Methyltransf_31; pfam13847 320373015660 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 320373015661 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373015662 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 320373015663 DNA binding site [nucleotide binding] 320373015664 active site 320373015665 Int/Topo IB signature motif; other site 320373015666 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 320373015667 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 320373015668 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 320373015669 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 320373015670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373015671 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 320373015672 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 320373015673 DNA binding residues [nucleotide binding] 320373015674 DNA primase; Validated; Region: dnaG; PRK05667 320373015675 CHC2 zinc finger; Region: zf-CHC2; pfam01807 320373015676 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 320373015677 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 320373015678 active site 320373015679 metal binding site [ion binding]; metal-binding site 320373015680 interdomain interaction site; other site 320373015681 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 320373015682 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 320373015683 Yqey-like protein; Region: YqeY; pfam09424 320373015684 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 320373015685 Predicted flavoproteins [General function prediction only]; Region: COG2081 320373015686 UGMP family protein; Validated; Region: PRK09604 320373015687 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 320373015688 putative GTP cyclohydrolase; Provisional; Region: PRK13674 320373015689 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 320373015690 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 320373015691 TPP-binding site; other site 320373015692 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 320373015693 PYR/PP interface [polypeptide binding]; other site 320373015694 dimer interface [polypeptide binding]; other site 320373015695 TPP binding site [chemical binding]; other site 320373015696 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 320373015697 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 320373015698 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 320373015699 substrate binding pocket [chemical binding]; other site 320373015700 chain length determination region; other site 320373015701 substrate-Mg2+ binding site; other site 320373015702 catalytic residues [active] 320373015703 aspartate-rich region 1; other site 320373015704 active site lid residues [active] 320373015705 aspartate-rich region 2; other site 320373015706 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 320373015707 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320373015708 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 320373015709 [2Fe-2S] cluster binding site [ion binding]; other site 320373015710 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 320373015711 alpha subunit interface [polypeptide binding]; other site 320373015712 active site 320373015713 substrate binding site [chemical binding]; other site 320373015714 Fe binding site [ion binding]; other site 320373015715 Transposase domain (DUF772); Region: DUF772; pfam05598 320373015716 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 320373015717 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 320373015718 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 320373015719 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 320373015720 active site residue [active] 320373015721 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 320373015722 active site residue [active] 320373015723 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 320373015724 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 320373015725 Predicted membrane protein [Function unknown]; Region: COG4655 320373015726 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 320373015727 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 320373015728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373015729 DNA polymerase I; Provisional; Region: PRK05755 320373015730 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 320373015731 active site 320373015732 metal binding site 1 [ion binding]; metal-binding site 320373015733 putative 5' ssDNA interaction site; other site 320373015734 metal binding site 3; metal-binding site 320373015735 metal binding site 2 [ion binding]; metal-binding site 320373015736 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 320373015737 putative DNA binding site [nucleotide binding]; other site 320373015738 putative metal binding site [ion binding]; other site 320373015739 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 320373015740 active site 320373015741 catalytic site [active] 320373015742 substrate binding site [chemical binding]; other site 320373015743 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 320373015744 active site 320373015745 DNA binding site [nucleotide binding] 320373015746 catalytic site [active] 320373015747 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 320373015748 Uncharacterized conserved protein [Function unknown]; Region: COG1683 320373015749 AMP nucleosidase; Provisional; Region: PRK08292 320373015750 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 320373015751 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 320373015752 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 320373015753 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 320373015754 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 320373015755 putative active site [active] 320373015756 putative substrate binding site [chemical binding]; other site 320373015757 ATP binding site [chemical binding]; other site 320373015758 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320373015759 MarR family; Region: MarR; pfam01047 320373015760 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 320373015761 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 320373015762 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 320373015763 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 320373015764 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 320373015765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373015766 putative PBP binding loops; other site 320373015767 dimer interface [polypeptide binding]; other site 320373015768 ABC-ATPase subunit interface; other site 320373015769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373015770 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 320373015771 Walker A/P-loop; other site 320373015772 ATP binding site [chemical binding]; other site 320373015773 Q-loop/lid; other site 320373015774 ABC transporter signature motif; other site 320373015775 Walker B; other site 320373015776 D-loop; other site 320373015777 H-loop/switch region; other site 320373015778 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 320373015779 molybdenum-pterin binding domain; Region: Mop; TIGR00638 320373015780 TOBE domain; Region: TOBE; cl01440 320373015781 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 320373015782 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 320373015783 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 320373015784 dimer interface [polypeptide binding]; other site 320373015785 hexamer interface [polypeptide binding]; other site 320373015786 active site 2 [active] 320373015787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373015788 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373015789 dimerization interface [polypeptide binding]; other site 320373015790 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 320373015791 EamA-like transporter family; Region: EamA; pfam00892 320373015792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373015793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373015794 dimer interface [polypeptide binding]; other site 320373015795 phosphorylation site [posttranslational modification] 320373015796 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 320373015797 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 320373015798 Domain of unknown function DUF21; Region: DUF21; pfam01595 320373015799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 320373015800 Transporter associated domain; Region: CorC_HlyC; smart01091 320373015801 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 320373015802 thiamine phosphate binding site [chemical binding]; other site 320373015803 active site 320373015804 pyrophosphate binding site [ion binding]; other site 320373015805 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 320373015806 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 320373015807 active site 320373015808 catalytic site [active] 320373015809 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 320373015810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373015811 S-adenosylmethionine binding site [chemical binding]; other site 320373015812 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 320373015813 DNA binding residues [nucleotide binding] 320373015814 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 320373015815 putative deacylase active site [active] 320373015816 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 320373015817 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 320373015818 phosphate binding site [ion binding]; other site 320373015819 Homeodomain-like domain; Region: HTH_23; pfam13384 320373015820 Winged helix-turn helix; Region: HTH_29; pfam13551 320373015821 Winged helix-turn helix; Region: HTH_33; pfam13592 320373015822 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373015823 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 320373015824 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373015825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373015826 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320373015827 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 320373015828 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 320373015829 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 320373015830 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 320373015831 active site 320373015832 catalytic residues [active] 320373015833 metal binding site [ion binding]; metal-binding site 320373015834 DmpG-like communication domain; Region: DmpG_comm; pfam07836 320373015835 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 320373015836 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 320373015837 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 320373015838 Thioesterase domain; Region: Thioesterase; pfam00975 320373015839 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 320373015840 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 320373015841 homodimer interface [polypeptide binding]; other site 320373015842 substrate-cofactor binding pocket; other site 320373015843 catalytic residue [active] 320373015844 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 320373015845 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 320373015846 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 320373015847 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 320373015848 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 320373015849 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 320373015850 acyl-activating enzyme (AAE) consensus motif; other site 320373015851 AMP binding site [chemical binding]; other site 320373015852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373015853 dimerization interface [polypeptide binding]; other site 320373015854 putative DNA binding site [nucleotide binding]; other site 320373015855 putative Zn2+ binding site [ion binding]; other site 320373015856 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 320373015857 putative hydrophobic ligand binding site [chemical binding]; other site 320373015858 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 320373015859 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320373015860 active site 320373015861 metal binding site [ion binding]; metal-binding site 320373015862 RES domain; Region: RES; smart00953 320373015863 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 320373015864 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 320373015865 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 320373015866 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 320373015867 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 320373015868 Cupin domain; Region: Cupin_2; cl17218 320373015869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373015870 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373015871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373015872 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 320373015873 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373015874 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 320373015875 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 320373015876 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373015877 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373015878 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 320373015879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 320373015880 active site 320373015881 tyrosine kinase; Provisional; Region: PRK11519 320373015882 Chain length determinant protein; Region: Wzz; cl15801 320373015883 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 320373015884 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 320373015885 polysaccharide export protein Wza; Provisional; Region: PRK15078 320373015886 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 320373015887 SLBB domain; Region: SLBB; pfam10531 320373015888 SLBB domain; Region: SLBB; pfam10531 320373015889 Low molecular weight phosphatase family; Region: LMWPc; cl00105 320373015890 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 320373015891 active site 320373015892 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 320373015893 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 320373015894 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 320373015895 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 320373015896 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 320373015897 Bacterial sugar transferase; Region: Bac_transf; pfam02397 320373015898 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 320373015899 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 320373015900 Substrate binding site; other site 320373015901 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 320373015902 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 320373015903 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 320373015904 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 320373015905 Cysteine-rich domain; Region: CCG; pfam02754 320373015906 Cysteine-rich domain; Region: CCG; pfam02754 320373015907 Rubrerythrin [Energy production and conversion]; Region: COG1592 320373015908 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 320373015909 binuclear metal center [ion binding]; other site 320373015910 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 320373015911 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 320373015912 amidase catalytic site [active] 320373015913 Zn binding residues [ion binding]; other site 320373015914 substrate binding site [chemical binding]; other site 320373015915 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 320373015916 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 320373015917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 320373015918 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 320373015919 putative hydrophobic ligand binding site [chemical binding]; other site 320373015920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 320373015921 YCII-related domain; Region: YCII; cl00999 320373015922 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 320373015923 generic binding surface I; other site 320373015924 generic binding surface II; other site 320373015925 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 320373015926 putative active site [active] 320373015927 putative catalytic site [active] 320373015928 putative Mg binding site IVb [ion binding]; other site 320373015929 putative phosphate binding site [ion binding]; other site 320373015930 putative DNA binding site [nucleotide binding]; other site 320373015931 putative Mg binding site IVa [ion binding]; other site 320373015932 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 320373015933 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 320373015934 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 320373015935 Domain of unknown function DUF20; Region: UPF0118; pfam01594 320373015936 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 320373015937 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 320373015938 N-terminal plug; other site 320373015939 ligand-binding site [chemical binding]; other site 320373015940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373015941 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 320373015942 Prostaglandin dehydrogenases; Region: PGDH; cd05288 320373015943 NAD(P) binding site [chemical binding]; other site 320373015944 substrate binding site [chemical binding]; other site 320373015945 dimer interface [polypeptide binding]; other site 320373015946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373015947 short chain dehydrogenase; Validated; Region: PRK07069 320373015948 NAD(P) binding site [chemical binding]; other site 320373015949 active site 320373015950 short chain dehydrogenase; Provisional; Region: PRK07035 320373015951 classical (c) SDRs; Region: SDR_c; cd05233 320373015952 NAD(P) binding site [chemical binding]; other site 320373015953 active site 320373015954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 320373015955 catalytic core [active] 320373015956 Phosphotransferase enzyme family; Region: APH; pfam01636 320373015957 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 320373015958 putative active site [active] 320373015959 putative substrate binding site [chemical binding]; other site 320373015960 ATP binding site [chemical binding]; other site 320373015961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373015962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373015963 active site 320373015964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373015965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373015966 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 320373015967 substrate binding pocket [chemical binding]; other site 320373015968 dimerization interface [polypeptide binding]; other site 320373015969 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 320373015970 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 320373015971 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 320373015972 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 320373015973 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 320373015974 Walker A/P-loop; other site 320373015975 ATP binding site [chemical binding]; other site 320373015976 Q-loop/lid; other site 320373015977 ABC transporter signature motif; other site 320373015978 Walker B; other site 320373015979 D-loop; other site 320373015980 H-loop/switch region; other site 320373015981 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 320373015982 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 320373015983 conserved cys residue [active] 320373015984 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 320373015985 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 320373015986 conserved cys residue [active] 320373015987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373015988 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 320373015989 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 320373015990 active site 320373015991 HIGH motif; other site 320373015992 dimer interface [polypeptide binding]; other site 320373015993 KMSKS motif; other site 320373015994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373015995 CAAX protease self-immunity; Region: Abi; pfam02517 320373015996 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 320373015997 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 320373015998 Cl- selectivity filter; other site 320373015999 Cl- binding residues [ion binding]; other site 320373016000 pore gating glutamate residue; other site 320373016001 dimer interface [polypeptide binding]; other site 320373016002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373016003 motif II; other site 320373016004 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 320373016005 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 320373016006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373016007 active site 320373016008 phosphorylation site [posttranslational modification] 320373016009 intermolecular recognition site; other site 320373016010 CheB methylesterase; Region: CheB_methylest; pfam01339 320373016011 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 320373016012 putative binding surface; other site 320373016013 active site 320373016014 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 320373016015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373016016 ATP binding site [chemical binding]; other site 320373016017 Mg2+ binding site [ion binding]; other site 320373016018 G-X-G motif; other site 320373016019 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 320373016020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373016021 Response regulator receiver domain; Region: Response_reg; pfam00072 320373016022 active site 320373016023 phosphorylation site [posttranslational modification] 320373016024 intermolecular recognition site; other site 320373016025 dimerization interface [polypeptide binding]; other site 320373016026 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 320373016027 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 320373016028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373016029 S-adenosylmethionine binding site [chemical binding]; other site 320373016030 TPR repeat; Region: TPR_11; pfam13414 320373016031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 320373016032 binding surface 320373016033 TPR motif; other site 320373016034 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 320373016035 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320373016036 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 320373016037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373016038 dimerization interface [polypeptide binding]; other site 320373016039 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373016040 dimer interface [polypeptide binding]; other site 320373016041 putative CheW interface [polypeptide binding]; other site 320373016042 Response regulator receiver domain; Region: Response_reg; pfam00072 320373016043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373016044 active site 320373016045 phosphorylation site [posttranslational modification] 320373016046 intermolecular recognition site; other site 320373016047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373016048 dimerization interface [polypeptide binding]; other site 320373016049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373016050 dimer interface [polypeptide binding]; other site 320373016051 phosphorylation site [posttranslational modification] 320373016052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373016053 ATP binding site [chemical binding]; other site 320373016054 Mg2+ binding site [ion binding]; other site 320373016055 G-X-G motif; other site 320373016056 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 320373016057 active site 320373016058 catalytic site [active] 320373016059 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 320373016060 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 320373016061 NAD(P) binding site [chemical binding]; other site 320373016062 catalytic residues [active] 320373016063 acetolactate synthase; Reviewed; Region: PRK08322 320373016064 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 320373016065 PYR/PP interface [polypeptide binding]; other site 320373016066 dimer interface [polypeptide binding]; other site 320373016067 TPP binding site [chemical binding]; other site 320373016068 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 320373016069 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 320373016070 TPP-binding site [chemical binding]; other site 320373016071 dimer interface [polypeptide binding]; other site 320373016072 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 320373016073 Protein of unknown function (DUF445); Region: DUF445; pfam04286 320373016074 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 320373016075 PLD-like domain; Region: PLDc_2; pfam13091 320373016076 putative active site [active] 320373016077 catalytic site [active] 320373016078 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 320373016079 PLD-like domain; Region: PLDc_2; pfam13091 320373016080 putative active site [active] 320373016081 catalytic site [active] 320373016082 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 320373016083 HIT family signature motif; other site 320373016084 catalytic residue [active] 320373016085 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 320373016086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373016087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373016088 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 320373016089 [2Fe-2S] cluster binding site [ion binding]; other site 320373016090 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 320373016091 inter-subunit interface; other site 320373016092 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 320373016093 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 320373016094 putative alpha subunit interface [polypeptide binding]; other site 320373016095 putative active site [active] 320373016096 putative substrate binding site [chemical binding]; other site 320373016097 Fe binding site [ion binding]; other site 320373016098 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373016099 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 320373016100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373016102 dimerization interface [polypeptide binding]; other site 320373016103 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 320373016104 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 320373016105 octamer interface [polypeptide binding]; other site 320373016106 active site 320373016107 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 320373016108 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 320373016109 dimer interface [polypeptide binding]; other site 320373016110 active site 320373016111 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 320373016112 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 320373016113 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 320373016114 Subunit I/III interface [polypeptide binding]; other site 320373016115 Subunit III/IV interface [polypeptide binding]; other site 320373016116 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 320373016117 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 320373016118 D-pathway; other site 320373016119 Putative ubiquinol binding site [chemical binding]; other site 320373016120 Low-spin heme (heme b) binding site [chemical binding]; other site 320373016121 Putative water exit pathway; other site 320373016122 Binuclear center (heme o3/CuB) [ion binding]; other site 320373016123 K-pathway; other site 320373016124 Putative proton exit pathway; other site 320373016125 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 320373016126 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 320373016127 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 320373016128 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 320373016129 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 320373016130 active site 320373016131 FMN binding site [chemical binding]; other site 320373016132 2,4-decadienoyl-CoA binding site; other site 320373016133 catalytic residue [active] 320373016134 4Fe-4S cluster binding site [ion binding]; other site 320373016135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 320373016136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373016137 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 320373016138 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 320373016139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 320373016140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373016141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016142 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373016143 dimerization interface [polypeptide binding]; other site 320373016144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373016145 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320373016146 NAD(P) binding site [chemical binding]; other site 320373016147 active site 320373016148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373016149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016150 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 320373016151 dimerizarion interface [polypeptide binding]; other site 320373016152 CrgA pocket; other site 320373016153 substrate binding pocket [chemical binding]; other site 320373016154 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 320373016155 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 320373016156 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 320373016157 putative alpha subunit interface [polypeptide binding]; other site 320373016158 putative active site [active] 320373016159 putative substrate binding site [chemical binding]; other site 320373016160 Fe binding site [ion binding]; other site 320373016161 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 320373016162 inter-subunit interface; other site 320373016163 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 320373016164 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 320373016165 catalytic loop [active] 320373016166 iron binding site [ion binding]; other site 320373016167 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 320373016168 FAD binding pocket [chemical binding]; other site 320373016169 FAD binding motif [chemical binding]; other site 320373016170 phosphate binding motif [ion binding]; other site 320373016171 beta-alpha-beta structure motif; other site 320373016172 NAD binding pocket [chemical binding]; other site 320373016173 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 320373016174 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 320373016175 putative NAD(P) binding site [chemical binding]; other site 320373016176 active site 320373016177 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 320373016178 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 320373016179 nucleophilic elbow; other site 320373016180 catalytic triad; other site 320373016181 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 320373016182 Isochorismatase family; Region: Isochorismatase; pfam00857 320373016183 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 320373016184 catalytic triad [active] 320373016185 conserved cis-peptide bond; other site 320373016186 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 320373016187 Asp-box motif; other site 320373016188 lysine transporter; Provisional; Region: PRK10836 320373016189 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 320373016190 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 320373016191 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 320373016192 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 320373016193 Beta-Casp domain; Region: Beta-Casp; smart01027 320373016194 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 320373016195 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 320373016196 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 320373016197 NAD(P) binding site [chemical binding]; other site 320373016198 homotetramer interface [polypeptide binding]; other site 320373016199 homodimer interface [polypeptide binding]; other site 320373016200 active site 320373016201 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 320373016202 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 320373016203 ligand binding site [chemical binding]; other site 320373016204 flexible hinge region; other site 320373016205 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 320373016206 putative switch regulator; other site 320373016207 non-specific DNA interactions [nucleotide binding]; other site 320373016208 DNA binding site [nucleotide binding] 320373016209 sequence specific DNA binding site [nucleotide binding]; other site 320373016210 putative cAMP binding site [chemical binding]; other site 320373016211 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 320373016212 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 320373016213 putative NAD(P) binding site [chemical binding]; other site 320373016214 putative substrate binding site [chemical binding]; other site 320373016215 catalytic Zn binding site [ion binding]; other site 320373016216 structural Zn binding site [ion binding]; other site 320373016217 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 320373016218 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 320373016219 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 320373016220 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 320373016221 BON domain; Region: BON; pfam04972 320373016222 BON domain; Region: BON; pfam04972 320373016223 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 320373016224 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 320373016225 ligand-binding site [chemical binding]; other site 320373016226 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 320373016227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373016228 dimer interface [polypeptide binding]; other site 320373016229 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 320373016230 putative CheW interface [polypeptide binding]; other site 320373016231 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 320373016232 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 320373016233 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 320373016234 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373016235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 320373016236 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320373016237 Walker A/P-loop; other site 320373016238 ATP binding site [chemical binding]; other site 320373016239 Q-loop/lid; other site 320373016240 ABC transporter signature motif; other site 320373016241 Walker B; other site 320373016242 D-loop; other site 320373016243 H-loop/switch region; other site 320373016244 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 320373016245 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 320373016246 FtsX-like permease family; Region: FtsX; pfam02687 320373016247 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 320373016248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 320373016249 Ligand Binding Site [chemical binding]; other site 320373016250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373016251 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 320373016252 HlyD family secretion protein; Region: HlyD; pfam00529 320373016253 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 320373016254 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 320373016255 HlyD family secretion protein; Region: HlyD_3; pfam13437 320373016256 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 320373016257 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 320373016258 Walker A/P-loop; other site 320373016259 ATP binding site [chemical binding]; other site 320373016260 Q-loop/lid; other site 320373016261 ABC transporter signature motif; other site 320373016262 Walker B; other site 320373016263 D-loop; other site 320373016264 H-loop/switch region; other site 320373016265 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 320373016266 Walker A/P-loop; other site 320373016267 ATP binding site [chemical binding]; other site 320373016268 Q-loop/lid; other site 320373016269 ABC transporter signature motif; other site 320373016270 Walker B; other site 320373016271 D-loop; other site 320373016272 H-loop/switch region; other site 320373016273 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320373016274 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 320373016275 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 320373016276 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 320373016277 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 320373016278 PAS fold; Region: PAS_4; pfam08448 320373016279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373016280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373016281 dimer interface [polypeptide binding]; other site 320373016282 phosphorylation site [posttranslational modification] 320373016283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373016284 ATP binding site [chemical binding]; other site 320373016285 Mg2+ binding site [ion binding]; other site 320373016286 G-X-G motif; other site 320373016287 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 320373016288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373016289 active site 320373016290 phosphorylation site [posttranslational modification] 320373016291 intermolecular recognition site; other site 320373016292 dimerization interface [polypeptide binding]; other site 320373016293 Cache domain; Region: Cache_2; pfam08269 320373016294 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 320373016295 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 320373016296 dimer interface [polypeptide binding]; other site 320373016297 putative CheW interface [polypeptide binding]; other site 320373016298 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 320373016299 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 320373016300 NAD binding site [chemical binding]; other site 320373016301 substrate binding site [chemical binding]; other site 320373016302 catalytic Zn binding site [ion binding]; other site 320373016303 tetramer interface [polypeptide binding]; other site 320373016304 structural Zn binding site [ion binding]; other site 320373016305 ATP synthase; Region: ATP-synt; pfam00231 320373016306 core domain interface [polypeptide binding]; other site 320373016307 delta subunit interface [polypeptide binding]; other site 320373016308 epsilon subunit interface [polypeptide binding]; other site 320373016309 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320373016310 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 320373016311 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 320373016312 Walker A motif; other site 320373016313 ATP binding site [chemical binding]; other site 320373016314 Walker B motif; other site 320373016315 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320373016316 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 320373016317 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 320373016318 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 320373016319 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 320373016320 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 320373016321 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 320373016322 gamma subunit interface [polypeptide binding]; other site 320373016323 epsilon subunit interface [polypeptide binding]; other site 320373016324 LBP interface [polypeptide binding]; other site 320373016325 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 320373016326 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 320373016327 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 320373016328 alpha subunit interaction interface [polypeptide binding]; other site 320373016329 Walker A motif; other site 320373016330 ATP binding site [chemical binding]; other site 320373016331 Walker B motif; other site 320373016332 inhibitor binding site; inhibition site 320373016333 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 320373016334 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 320373016335 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 320373016336 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 320373016337 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 320373016338 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 320373016339 dimer interaction site [polypeptide binding]; other site 320373016340 substrate-binding tunnel; other site 320373016341 active site 320373016342 catalytic site [active] 320373016343 substrate binding site [chemical binding]; other site 320373016344 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 320373016345 acetate kinase; Provisional; Region: PRK07058 320373016346 propionate/acetate kinase; Provisional; Region: PRK12379 320373016347 6-phosphofructokinase 2; Provisional; Region: PRK10294 320373016348 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 320373016349 putative substrate binding site [chemical binding]; other site 320373016350 putative ATP binding site [chemical binding]; other site 320373016351 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 320373016352 BON domain; Region: BON; pfam04972 320373016353 BON domain; Region: BON; pfam04972 320373016354 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 320373016355 active site 320373016356 catalytic motif [active] 320373016357 Zn binding site [ion binding]; other site 320373016358 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 320373016359 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 320373016360 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 320373016361 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 320373016362 deoxyribose-phosphate aldolase; Provisional; Region: PRK05283 320373016363 catalytic residue [active] 320373016364 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 320373016365 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 320373016366 Nucleoside recognition; Region: Gate; pfam07670 320373016367 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 320373016368 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 320373016369 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 320373016370 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 320373016371 putative C-terminal domain interface [polypeptide binding]; other site 320373016372 putative GSH binding site (G-site) [chemical binding]; other site 320373016373 putative dimer interface [polypeptide binding]; other site 320373016374 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 320373016375 putative N-terminal domain interface [polypeptide binding]; other site 320373016376 putative dimer interface [polypeptide binding]; other site 320373016377 putative substrate binding pocket (H-site) [chemical binding]; other site 320373016378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373016379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016380 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 320373016381 putative effector binding pocket; other site 320373016382 dimerization interface [polypeptide binding]; other site 320373016383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373016384 short chain dehydrogenase; Provisional; Region: PRK06181 320373016385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373016386 NAD(P) binding site [chemical binding]; other site 320373016387 active site 320373016388 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 320373016389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 320373016390 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373016391 Cache domain; Region: Cache_1; pfam02743 320373016392 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320373016393 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373016394 metal binding site [ion binding]; metal-binding site 320373016395 active site 320373016396 I-site; other site 320373016397 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 320373016398 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 320373016399 peptidase domain interface [polypeptide binding]; other site 320373016400 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 320373016401 active site 320373016402 catalytic triad [active] 320373016403 calcium binding site [ion binding]; other site 320373016404 Phospholipid methyltransferase; Region: PEMT; cl17370 320373016405 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 320373016406 Chain length determinant protein; Region: Wzz; pfam02706 320373016407 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 320373016408 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 320373016409 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 320373016410 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 320373016411 putative metal binding site [ion binding]; other site 320373016412 putative homodimer interface [polypeptide binding]; other site 320373016413 putative homotetramer interface [polypeptide binding]; other site 320373016414 putative homodimer-homodimer interface [polypeptide binding]; other site 320373016415 putative allosteric switch controlling residues; other site 320373016416 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 320373016417 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 320373016418 Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins; Region: PLDc_DNaseII_1; cd09120 320373016419 Deoxyribonuclease II; Region: DNase_II; pfam03265 320373016420 putative active site [active] 320373016421 catalytic site [active] 320373016422 Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins; Region: PLDc_DNaseII_2; cd09121 320373016423 putative active site [active] 320373016424 catalytic site [active] 320373016425 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 320373016426 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 320373016427 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 320373016428 active site 320373016429 metal binding site [ion binding]; metal-binding site 320373016430 Ferritin-like; Region: Ferritin-like; pfam12902 320373016431 aldolase II superfamily protein; Provisional; Region: PRK07044 320373016432 intersubunit interface [polypeptide binding]; other site 320373016433 active site 320373016434 Zn2+ binding site [ion binding]; other site 320373016435 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 320373016436 putative uracil binding site [chemical binding]; other site 320373016437 putative active site [active] 320373016438 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 320373016439 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 320373016440 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 320373016441 active site 320373016442 catalytic triad [active] 320373016443 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 320373016444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373016445 active site 320373016446 phosphorylation site [posttranslational modification] 320373016447 intermolecular recognition site; other site 320373016448 dimerization interface [polypeptide binding]; other site 320373016449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 320373016450 DNA binding site [nucleotide binding] 320373016451 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 320373016452 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 320373016453 dimerization interface [polypeptide binding]; other site 320373016454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373016455 dimer interface [polypeptide binding]; other site 320373016456 phosphorylation site [posttranslational modification] 320373016457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373016458 ATP binding site [chemical binding]; other site 320373016459 Mg2+ binding site [ion binding]; other site 320373016460 G-X-G motif; other site 320373016461 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 320373016462 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 320373016463 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 320373016464 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 320373016465 Phosphoesterase family; Region: Phosphoesterase; pfam04185 320373016466 Iron permease FTR1 family; Region: FTR1; cl00475 320373016467 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 320373016468 CTP synthase; Region: PyrG; TIGR00337 320373016469 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373016470 substrate binding pocket [chemical binding]; other site 320373016471 membrane-bound complex binding site; other site 320373016472 hinge residues; other site 320373016473 Predicted metal-binding protein [General function prediction only]; Region: COG3019 320373016474 Transposase; Region: HTH_Tnp_1; cl17663 320373016475 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 320373016476 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 320373016477 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 320373016478 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 320373016479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 320373016480 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit of aminopyrrolnitrin oxygenase (PrnD). PrnD is a novel Rieske N-oxygenase that catalyzes the final step in the pyrrolnitrin biosynthetic pathway, the oxidation...; Region: Rieske_RO_Alpha_PrnD; cd03537 320373016481 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 320373016482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 320373016483 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 320373016484 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 320373016485 glutaminase active site [active] 320373016486 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 320373016487 dimer interface [polypeptide binding]; other site 320373016488 active site 320373016489 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 320373016490 dimer interface [polypeptide binding]; other site 320373016491 active site 320373016492 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 320373016493 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 320373016494 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 320373016495 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 320373016496 DXD motif; other site 320373016497 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 320373016498 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 320373016499 active site 320373016500 homodimer interface [polypeptide binding]; other site 320373016501 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 320373016502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373016504 dimerization interface [polypeptide binding]; other site 320373016505 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 320373016506 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 320373016507 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 320373016508 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 320373016509 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 320373016510 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373016511 catalytic residue [active] 320373016512 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 320373016513 D-mannose binding lectin; Region: B_lectin; pfam01453 320373016514 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 320373016515 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 320373016516 NAD binding site [chemical binding]; other site 320373016517 catalytic Zn binding site [ion binding]; other site 320373016518 structural Zn binding site [ion binding]; other site 320373016519 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 320373016520 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 320373016521 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373016522 catalytic residue [active] 320373016523 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 320373016524 N- and C-terminal domain interface [polypeptide binding]; other site 320373016525 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 320373016526 active site 320373016527 MgATP binding site [chemical binding]; other site 320373016528 catalytic site [active] 320373016529 metal binding site [ion binding]; metal-binding site 320373016530 xylulose binding site [chemical binding]; other site 320373016531 putative homodimer interface [polypeptide binding]; other site 320373016532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 320373016533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 320373016534 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373016535 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373016536 active site 320373016537 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320373016538 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 320373016539 NAD(P) binding site [chemical binding]; other site 320373016540 substrate binding site [chemical binding]; other site 320373016541 homotetramer interface [polypeptide binding]; other site 320373016542 active site 320373016543 homodimer interface [polypeptide binding]; other site 320373016544 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 320373016545 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 320373016546 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 320373016547 active site 320373016548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 320373016549 enoyl-CoA hydratase; Provisional; Region: PRK07468 320373016550 substrate binding site [chemical binding]; other site 320373016551 oxyanion hole (OAH) forming residues; other site 320373016552 trimer interface [polypeptide binding]; other site 320373016553 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 320373016554 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 320373016555 ATP-grasp domain; Region: ATP-grasp_4; cl17255 320373016556 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 320373016557 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 320373016558 carboxyltransferase (CT) interaction site; other site 320373016559 biotinylation site [posttranslational modification]; other site 320373016560 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 320373016561 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 320373016562 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 320373016563 acyl-activating enzyme (AAE) consensus motif; other site 320373016564 AMP binding site [chemical binding]; other site 320373016565 active site 320373016566 CoA binding site [chemical binding]; other site 320373016567 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 320373016568 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320373016569 Di-iron ligands [ion binding]; other site 320373016570 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 320373016571 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 320373016572 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 320373016573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373016574 S-adenosylmethionine binding site [chemical binding]; other site 320373016575 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 320373016576 Fatty acid desaturase; Region: FA_desaturase; pfam00487 320373016577 Di-iron ligands [ion binding]; other site 320373016578 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 320373016579 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 320373016580 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 320373016581 active site 320373016582 acyl-CoA synthetase; Validated; Region: PRK05850 320373016583 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 320373016584 acyl-activating enzyme (AAE) consensus motif; other site 320373016585 active site 320373016586 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 320373016587 CoenzymeA binding site [chemical binding]; other site 320373016588 subunit interaction site [polypeptide binding]; other site 320373016589 PHB binding site; other site 320373016590 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373016591 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 320373016592 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 320373016593 dimer interface [polypeptide binding]; other site 320373016594 ADP-ribose binding site [chemical binding]; other site 320373016595 active site 320373016596 nudix motif; other site 320373016597 metal binding site [ion binding]; metal-binding site 320373016598 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 320373016599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373016600 motif II; other site 320373016601 Transposase, Mutator family; Region: Transposase_mut; pfam00872 320373016602 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 320373016603 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 320373016604 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 320373016605 RHS Repeat; Region: RHS_repeat; pfam05593 320373016606 RHS Repeat; Region: RHS_repeat; pfam05593 320373016607 RHS Repeat; Region: RHS_repeat; pfam05593 320373016608 RHS Repeat; Region: RHS_repeat; cl11982 320373016609 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 320373016610 RHS Repeat; Region: RHS_repeat; cl11982 320373016611 RHS protein; Region: RHS; pfam03527 320373016612 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 320373016613 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 320373016614 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 320373016615 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 320373016616 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 320373016617 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 320373016618 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 320373016619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373016620 Walker A motif; other site 320373016621 ATP binding site [chemical binding]; other site 320373016622 Walker B motif; other site 320373016623 arginine finger; other site 320373016624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373016625 Walker A motif; other site 320373016626 ATP binding site [chemical binding]; other site 320373016627 Walker B motif; other site 320373016628 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 320373016629 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 320373016630 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 320373016631 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 320373016632 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 320373016633 Protein of unknown function (DUF796); Region: DUF796; pfam05638 320373016634 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 320373016635 Protein of unknown function (DUF877); Region: DUF877; pfam05943 320373016636 Protein of unknown function (DUF770); Region: DUF770; pfam05591 320373016637 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 320373016638 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 320373016639 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 320373016640 Catalytic domain of Protein Kinases; Region: PKc; cd00180 320373016641 active site 320373016642 ATP binding site [chemical binding]; other site 320373016643 substrate binding site [chemical binding]; other site 320373016644 activation loop (A-loop); other site 320373016645 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 320373016646 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 320373016647 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 320373016648 G1 box; other site 320373016649 GTP/Mg2+ binding site [chemical binding]; other site 320373016650 G2 box; other site 320373016651 G3 box; other site 320373016652 Switch II region; other site 320373016653 G4 box; other site 320373016654 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 320373016655 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 320373016656 hypothetical protein; Provisional; Region: PRK07033 320373016657 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 320373016658 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 320373016659 ligand binding site [chemical binding]; other site 320373016660 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 320373016661 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 320373016662 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 320373016663 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 320373016664 phosphopeptide binding site; other site 320373016665 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 320373016666 hypothetical protein; Provisional; Region: PRK07538 320373016667 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 320373016668 Chorismate lyase; Region: Chor_lyase; cl01230 320373016669 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 320373016670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 320373016671 NAD(P) binding site [chemical binding]; other site 320373016672 active site 320373016673 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320373016674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016675 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 320373016676 dimerization interface [polypeptide binding]; other site 320373016677 substrate binding pocket [chemical binding]; other site 320373016678 D-serine dehydratase; Provisional; Region: PRK02991 320373016679 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 320373016680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373016681 catalytic residue [active] 320373016682 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 320373016683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373016685 dimerization interface [polypeptide binding]; other site 320373016686 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 320373016687 metabolite-proton symporter; Region: 2A0106; TIGR00883 320373016688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373016689 putative substrate translocation pore; other site 320373016690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373016692 dimerization interface [polypeptide binding]; other site 320373016693 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 320373016694 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 320373016695 phosphate binding site [ion binding]; other site 320373016696 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 320373016697 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 320373016698 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373016699 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 320373016700 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373016701 indole acetimide hydrolase; Validated; Region: PRK07488 320373016702 Amidase; Region: Amidase; pfam01425 320373016703 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 320373016704 CoA binding domain; Region: CoA_binding_2; pfam13380 320373016705 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 320373016706 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 320373016707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 320373016708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373016709 Coenzyme A binding pocket [chemical binding]; other site 320373016710 H-NS histone family; Region: Histone_HNS; pfam00816 320373016711 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 320373016712 PAS fold; Region: PAS_4; pfam08448 320373016713 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320373016714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373016715 Walker B motif; other site 320373016716 arginine finger; other site 320373016717 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373016718 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 320373016719 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 320373016720 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 320373016721 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 320373016722 active site residue [active] 320373016723 outer membrane porin, OprD family; Region: OprD; pfam03573 320373016724 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 320373016725 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373016726 Walker A/P-loop; other site 320373016727 ATP binding site [chemical binding]; other site 320373016728 Q-loop/lid; other site 320373016729 ABC transporter signature motif; other site 320373016730 Walker B; other site 320373016731 D-loop; other site 320373016732 H-loop/switch region; other site 320373016733 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320373016734 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 320373016735 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 320373016736 Walker A/P-loop; other site 320373016737 ATP binding site [chemical binding]; other site 320373016738 Q-loop/lid; other site 320373016739 ABC transporter signature motif; other site 320373016740 Walker B; other site 320373016741 D-loop; other site 320373016742 H-loop/switch region; other site 320373016743 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 320373016744 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 320373016745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373016746 dimer interface [polypeptide binding]; other site 320373016747 conserved gate region; other site 320373016748 putative PBP binding loops; other site 320373016749 ABC-ATPase subunit interface; other site 320373016750 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 320373016751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373016752 dimer interface [polypeptide binding]; other site 320373016753 conserved gate region; other site 320373016754 putative PBP binding loops; other site 320373016755 ABC-ATPase subunit interface; other site 320373016756 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 320373016757 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 320373016758 peptide binding site [polypeptide binding]; other site 320373016759 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 320373016760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373016761 non-specific DNA binding site [nucleotide binding]; other site 320373016762 salt bridge; other site 320373016763 sequence-specific DNA binding site [nucleotide binding]; other site 320373016764 Cupin domain; Region: Cupin_2; pfam07883 320373016765 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 320373016766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373016767 putative substrate translocation pore; other site 320373016768 POT family; Region: PTR2; cl17359 320373016769 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 320373016770 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 320373016771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016772 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 320373016773 substrate binding pocket [chemical binding]; other site 320373016774 dimerization interface [polypeptide binding]; other site 320373016775 Putative cyclase; Region: Cyclase; cl00814 320373016776 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 320373016777 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 320373016778 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320373016779 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320373016780 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 320373016781 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 320373016782 NAD(P) binding site [chemical binding]; other site 320373016783 Isochorismatase family; Region: Isochorismatase; pfam00857 320373016784 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 320373016785 catalytic triad [active] 320373016786 conserved cis-peptide bond; other site 320373016787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373016788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 320373016789 putative substrate translocation pore; other site 320373016790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373016791 phosphate:H+ symporter; Region: 2A0109; TIGR00887 320373016792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373016793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373016794 putative substrate translocation pore; other site 320373016795 Putative cyclase; Region: Cyclase; cl00814 320373016796 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 320373016797 CoA-transferase family III; Region: CoA_transf_3; pfam02515 320373016798 Transcriptional regulator [Transcription]; Region: IclR; COG1414 320373016799 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 320373016800 Bacterial transcriptional regulator; Region: IclR; pfam01614 320373016801 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 320373016802 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373016803 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373016804 trimer interface [polypeptide binding]; other site 320373016805 eyelet of channel; other site 320373016806 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 320373016807 2-methylcitrate dehydratase; Region: prpD; TIGR02330 320373016808 OpgC protein; Region: OpgC_C; pfam10129 320373016809 Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]; Region: DBF4; COG5067 320373016810 Predicted permeases [General function prediction only]; Region: RarD; COG2962 320373016811 acylphosphatase; Provisional; Region: PRK14424 320373016812 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 320373016813 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 320373016814 putative NADP binding site [chemical binding]; other site 320373016815 putative substrate binding site [chemical binding]; other site 320373016816 active site 320373016817 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 320373016818 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 320373016819 active site 320373016820 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 320373016821 LytB protein; Region: LYTB; pfam02401 320373016822 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 320373016823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 320373016824 FeS/SAM binding site; other site 320373016825 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 320373016826 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 320373016827 aminotransferase; Validated; Region: PRK07046 320373016828 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 320373016829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 320373016830 catalytic residue [active] 320373016831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 320373016832 sequence-specific DNA binding site [nucleotide binding]; other site 320373016833 salt bridge; other site 320373016834 Protein of unknown function (DUF466); Region: DUF466; pfam04328 320373016835 carbon starvation protein A; Provisional; Region: PRK15015 320373016836 Carbon starvation protein CstA; Region: CstA; pfam02554 320373016837 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 320373016838 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373016839 Uncharacterized conserved protein [Function unknown]; Region: COG5476 320373016840 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 320373016841 MlrC C-terminus; Region: MlrC_C; pfam07171 320373016842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373016843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373016845 dimerization interface [polypeptide binding]; other site 320373016846 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 320373016847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 320373016848 metal binding site [ion binding]; metal-binding site 320373016849 SnoaL-like domain; Region: SnoaL_2; pfam12680 320373016850 Predicted membrane protein [Function unknown]; Region: COG2246 320373016851 GtrA-like protein; Region: GtrA; pfam04138 320373016852 Methyltransferase domain; Region: Methyltransf_23; pfam13489 320373016853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 320373016854 S-adenosylmethionine binding site [chemical binding]; other site 320373016855 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 320373016856 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 320373016857 Ligand binding site; other site 320373016858 Putative Catalytic site; other site 320373016859 DXD motif; other site 320373016860 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 320373016861 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 320373016862 Flp/Fap pilin component; Region: Flp_Fap; cl01585 320373016863 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 320373016864 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 320373016865 active site 320373016866 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 320373016867 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 320373016868 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 320373016869 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 320373016870 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 320373016871 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 320373016872 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 320373016873 TadE-like protein; Region: TadE; pfam07811 320373016874 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 320373016875 TadE-like protein; Region: TadE; pfam07811 320373016876 AAA domain; Region: AAA_31; pfam13614 320373016877 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 320373016878 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 320373016879 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 320373016880 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 320373016881 ATP binding site [chemical binding]; other site 320373016882 Walker A motif; other site 320373016883 hexamer interface [polypeptide binding]; other site 320373016884 Walker B motif; other site 320373016885 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 320373016886 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373016887 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 320373016888 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 320373016889 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 320373016890 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 320373016891 putative DNA binding site [nucleotide binding]; other site 320373016892 putative Zn2+ binding site [ion binding]; other site 320373016893 AsnC family; Region: AsnC_trans_reg; pfam01037 320373016894 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 320373016895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 320373016896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373016897 homodimer interface [polypeptide binding]; other site 320373016898 catalytic residue [active] 320373016899 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 320373016900 homotrimer interaction site [polypeptide binding]; other site 320373016901 putative active site [active] 320373016902 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373016903 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373016904 trimer interface [polypeptide binding]; other site 320373016905 eyelet of channel; other site 320373016906 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 320373016907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 320373016908 DNA-binding site [nucleotide binding]; DNA binding site 320373016909 Transcriptional regulators [Transcription]; Region: FadR; COG2186 320373016910 Uncharacterized conserved protein [Function unknown]; Region: COG5476 320373016911 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 320373016912 MlrC C-terminus; Region: MlrC_C; pfam07171 320373016913 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 320373016914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373016915 putative substrate translocation pore; other site 320373016916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373016917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373016918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 320373016919 dimerization interface [polypeptide binding]; other site 320373016920 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 320373016921 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 320373016922 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 320373016923 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 320373016924 active site 320373016925 DNA binding site [nucleotide binding] 320373016926 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 320373016927 DNA binding site [nucleotide binding] 320373016928 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 320373016929 nucleotide binding site [chemical binding]; other site 320373016930 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 320373016931 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 320373016932 putative DNA binding site [nucleotide binding]; other site 320373016933 putative homodimer interface [polypeptide binding]; other site 320373016934 Predicted membrane protein [Function unknown]; Region: COG2323 320373016935 hydroperoxidase II; Provisional; Region: katE; PRK11249 320373016936 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 320373016937 tetramer interface [polypeptide binding]; other site 320373016938 heme binding pocket [chemical binding]; other site 320373016939 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 320373016940 domain interactions; other site 320373016941 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 320373016942 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 320373016943 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 320373016944 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 320373016945 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 320373016946 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 320373016947 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 320373016948 dimanganese center [ion binding]; other site 320373016949 Domain of unknown function (DUF892); Region: DUF892; pfam05974 320373016950 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 320373016951 MltA-interacting protein MipA; Region: MipA; cl01504 320373016952 FOG: CBS domain [General function prediction only]; Region: COG0517 320373016953 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 320373016954 PRC-barrel domain; Region: PRC; pfam05239 320373016955 Response regulator receiver domain; Region: Response_reg; pfam00072 320373016956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373016957 active site 320373016958 phosphorylation site [posttranslational modification] 320373016959 intermolecular recognition site; other site 320373016960 dimerization interface [polypeptide binding]; other site 320373016961 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 320373016962 Fe-S cluster binding site [ion binding]; other site 320373016963 active site 320373016964 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 320373016965 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 320373016966 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 320373016967 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 320373016968 NAD binding site [chemical binding]; other site 320373016969 catalytic Zn binding site [ion binding]; other site 320373016970 structural Zn binding site [ion binding]; other site 320373016971 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 320373016972 short chain dehydrogenase; Provisional; Region: PRK06701 320373016973 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 320373016974 NAD binding site [chemical binding]; other site 320373016975 metal binding site [ion binding]; metal-binding site 320373016976 active site 320373016977 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 320373016978 short chain dehydrogenase; Provisional; Region: PRK07109 320373016979 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 320373016980 putative NAD(P) binding site [chemical binding]; other site 320373016981 active site 320373016982 BON domain; Region: BON; pfam04972 320373016983 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 320373016984 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 320373016985 putative ADP-binding pocket [chemical binding]; other site 320373016986 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 320373016987 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 320373016988 NAD binding site [chemical binding]; other site 320373016989 putative substrate binding site 2 [chemical binding]; other site 320373016990 putative substrate binding site 1 [chemical binding]; other site 320373016991 active site 320373016992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373016993 PAS domain; Region: PAS_9; pfam13426 320373016994 putative active site [active] 320373016995 heme pocket [chemical binding]; other site 320373016996 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 320373016997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373016998 putative active site [active] 320373016999 heme pocket [chemical binding]; other site 320373017000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373017001 dimer interface [polypeptide binding]; other site 320373017002 phosphorylation site [posttranslational modification] 320373017003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373017004 ATP binding site [chemical binding]; other site 320373017005 Mg2+ binding site [ion binding]; other site 320373017006 G-X-G motif; other site 320373017007 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 320373017008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373017009 active site 320373017010 phosphorylation site [posttranslational modification] 320373017011 intermolecular recognition site; other site 320373017012 dimerization interface [polypeptide binding]; other site 320373017013 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 320373017014 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 320373017015 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320373017016 active site 320373017017 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 320373017018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373017019 active site 320373017020 phosphorylation site [posttranslational modification] 320373017021 intermolecular recognition site; other site 320373017022 dimerization interface [polypeptide binding]; other site 320373017023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373017024 Walker A motif; other site 320373017025 ATP binding site [chemical binding]; other site 320373017026 Walker B motif; other site 320373017027 arginine finger; other site 320373017028 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 320373017029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 320373017030 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 320373017031 Walker A motif; other site 320373017032 ATP binding site [chemical binding]; other site 320373017033 Walker B motif; other site 320373017034 arginine finger; other site 320373017035 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 320373017036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 320373017037 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373017038 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320373017039 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373017040 putative active site [active] 320373017041 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 320373017042 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 320373017043 active site 320373017044 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 320373017045 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 320373017046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 320373017047 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 320373017048 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 320373017049 putative active site [active] 320373017050 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 320373017051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 320373017052 active site 320373017053 motif I; other site 320373017054 motif II; other site 320373017055 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 320373017056 classical (c) SDRs; Region: SDR_c; cd05233 320373017057 NAD(P) binding site [chemical binding]; other site 320373017058 active site 320373017059 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 320373017060 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 320373017061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373017062 Walker A/P-loop; other site 320373017063 ATP binding site [chemical binding]; other site 320373017064 Q-loop/lid; other site 320373017065 ABC transporter signature motif; other site 320373017066 Walker B; other site 320373017067 D-loop; other site 320373017068 H-loop/switch region; other site 320373017069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 320373017070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373017071 Response regulator receiver domain; Region: Response_reg; pfam00072 320373017072 active site 320373017073 phosphorylation site [posttranslational modification] 320373017074 intermolecular recognition site; other site 320373017075 dimerization interface [polypeptide binding]; other site 320373017076 BON domain; Region: BON; pfam04972 320373017077 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 320373017078 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 320373017079 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12575 320373017080 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 320373017081 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 320373017082 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 320373017083 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 320373017084 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 320373017085 active site 320373017086 non-prolyl cis peptide bond; other site 320373017087 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 320373017088 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 320373017089 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 320373017090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 320373017091 putative substrate translocation pore; other site 320373017092 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 320373017093 Autoinducer binding domain; Region: Autoind_bind; pfam03472 320373017094 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 320373017095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373017096 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 320373017097 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 320373017098 E3 interaction surface; other site 320373017099 lipoyl attachment site [posttranslational modification]; other site 320373017100 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 320373017101 e3 binding domain; Region: E3_binding; pfam02817 320373017102 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 320373017103 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 320373017104 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 320373017105 alpha subunit interface [polypeptide binding]; other site 320373017106 TPP binding site [chemical binding]; other site 320373017107 heterodimer interface [polypeptide binding]; other site 320373017108 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 320373017109 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 320373017110 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 320373017111 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 320373017112 tetramer interface [polypeptide binding]; other site 320373017113 TPP-binding site [chemical binding]; other site 320373017114 heterodimer interface [polypeptide binding]; other site 320373017115 phosphorylation loop region [posttranslational modification] 320373017116 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 320373017117 putative hydrophobic ligand binding site [chemical binding]; other site 320373017118 protein interface [polypeptide binding]; other site 320373017119 gate; other site 320373017120 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 320373017121 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 320373017122 hydrophobic ligand binding site; other site 320373017123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 320373017124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 320373017125 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 320373017126 substrate binding pocket [chemical binding]; other site 320373017127 dimerization interface [polypeptide binding]; other site 320373017128 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 320373017129 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 320373017130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 320373017131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 320373017132 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 320373017133 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 320373017134 nucleophile elbow; other site 320373017135 Patatin phospholipase; Region: DUF3734; pfam12536 320373017136 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 320373017137 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 320373017138 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 320373017139 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 320373017140 active site 320373017141 dimer interface [polypeptide binding]; other site 320373017142 effector binding site; other site 320373017143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 320373017144 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 320373017145 AAA domain; Region: AAA_33; pfam13671 320373017146 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 320373017147 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 320373017148 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 320373017149 Sulfate transporter family; Region: Sulfate_transp; pfam00916 320373017150 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 320373017151 FOG: CBS domain [General function prediction only]; Region: COG0517 320373017152 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 320373017153 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 320373017154 putative FMN binding site [chemical binding]; other site 320373017155 NADPH bind site [chemical binding]; other site 320373017156 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 320373017157 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 320373017158 putative dimer interface [polypeptide binding]; other site 320373017159 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 320373017160 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373017161 molybdopterin cofactor binding site; other site 320373017162 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 320373017163 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 320373017164 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 320373017165 putative molybdopterin cofactor binding site; other site 320373017166 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 320373017167 4Fe-4S binding domain; Region: Fer4; pfam00037 320373017168 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 320373017169 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 320373017170 putative active site [active] 320373017171 putative metal binding site [ion binding]; other site 320373017172 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 320373017173 Transglycosylase; Region: Transgly; pfam00912 320373017174 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 320373017175 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 320373017176 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 320373017177 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 320373017178 catalytic residues [active] 320373017179 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 320373017180 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 320373017181 trimer interface [polypeptide binding]; other site 320373017182 eyelet of channel; other site 320373017183 amidase; Provisional; Region: PRK08137 320373017184 Amidase; Region: Amidase; cl11426 320373017185 putative acetyltransferase YhhY; Provisional; Region: PRK10140 320373017186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 320373017187 Coenzyme A binding pocket [chemical binding]; other site 320373017188 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 320373017189 Coenzyme A binding pocket [chemical binding]; other site 320373017190 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 320373017191 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 320373017192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 320373017193 D-loop; other site 320373017194 H-loop/switch region; other site 320373017195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 320373017196 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 320373017197 Histidine kinase; Region: HisKA_3; pfam07730 320373017198 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 320373017199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 320373017200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373017201 active site 320373017202 phosphorylation site [posttranslational modification] 320373017203 intermolecular recognition site; other site 320373017204 dimerization interface [polypeptide binding]; other site 320373017205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 320373017206 DNA binding residues [nucleotide binding] 320373017207 dimerization interface [polypeptide binding]; other site 320373017208 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 320373017209 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 320373017210 PAS domain; Region: PAS_9; pfam13426 320373017211 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373017212 putative active site [active] 320373017213 heme pocket [chemical binding]; other site 320373017214 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320373017215 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373017216 metal binding site [ion binding]; metal-binding site 320373017217 active site 320373017218 I-site; other site 320373017219 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 320373017220 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 320373017221 Lipase (class 2); Region: Lipase_2; pfam01674 320373017222 PGAP1-like protein; Region: PGAP1; pfam07819 320373017223 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 320373017224 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 320373017225 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 320373017226 FtsX-like permease family; Region: FtsX; pfam02687 320373017227 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 320373017228 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 320373017229 Walker A/P-loop; other site 320373017230 ATP binding site [chemical binding]; other site 320373017231 Q-loop/lid; other site 320373017232 ABC transporter signature motif; other site 320373017233 Walker B; other site 320373017234 D-loop; other site 320373017235 H-loop/switch region; other site 320373017236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 320373017237 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 320373017238 Cytochrome P450; Region: p450; cl12078 320373017239 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 320373017240 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320373017241 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320373017242 putative NADP binding site [chemical binding]; other site 320373017243 active site 320373017244 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 320373017245 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 320373017246 putative NAD(P) binding site [chemical binding]; other site 320373017247 active site 320373017248 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320373017249 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 320373017250 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 320373017251 active site 320373017252 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 320373017253 active site 320373017254 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 320373017255 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 320373017256 putative NADP binding site [chemical binding]; other site 320373017257 active site 320373017258 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 320373017259 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 320373017260 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 320373017261 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 320373017262 VacJ like lipoprotein; Region: VacJ; cl01073 320373017263 hypothetical protein; Provisional; Region: PRK07483 320373017264 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 320373017265 inhibitor-cofactor binding pocket; inhibition site 320373017266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 320373017267 catalytic residue [active] 320373017268 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 320373017269 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 320373017270 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 320373017271 Walker A/P-loop; other site 320373017272 ATP binding site [chemical binding]; other site 320373017273 Q-loop/lid; other site 320373017274 ABC transporter signature motif; other site 320373017275 Walker B; other site 320373017276 D-loop; other site 320373017277 H-loop/switch region; other site 320373017278 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 320373017279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 320373017280 dimer interface [polypeptide binding]; other site 320373017281 conserved gate region; other site 320373017282 putative PBP binding loops; other site 320373017283 ABC-ATPase subunit interface; other site 320373017284 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 320373017285 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 320373017286 substrate binding pocket [chemical binding]; other site 320373017287 membrane-bound complex binding site; other site 320373017288 hinge residues; other site 320373017289 hypothetical protein; Provisional; Region: PRK07077 320373017290 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 320373017291 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 320373017292 Active site cavity [active] 320373017293 catalytic acid [active] 320373017294 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 320373017295 active site lid residues [active] 320373017296 substrate binding pocket [chemical binding]; other site 320373017297 catalytic residues [active] 320373017298 substrate-Mg2+ binding site; other site 320373017299 aspartate-rich region 1; other site 320373017300 aspartate-rich region 2; other site 320373017301 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 320373017302 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 320373017303 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 320373017304 PAS fold; Region: PAS_4; pfam08448 320373017305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 320373017306 putative active site [active] 320373017307 heme pocket [chemical binding]; other site 320373017308 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 320373017309 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 320373017310 metal binding site [ion binding]; metal-binding site 320373017311 active site 320373017312 I-site; other site 320373017313 Response regulator receiver domain; Region: Response_reg; pfam00072 320373017314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373017315 active site 320373017316 phosphorylation site [posttranslational modification] 320373017317 intermolecular recognition site; other site 320373017318 dimerization interface [polypeptide binding]; other site 320373017319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 320373017320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 320373017321 dimer interface [polypeptide binding]; other site 320373017322 phosphorylation site [posttranslational modification] 320373017323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 320373017324 ATP binding site [chemical binding]; other site 320373017325 Mg2+ binding site [ion binding]; other site 320373017326 G-X-G motif; other site 320373017327 Response regulator receiver domain; Region: Response_reg; pfam00072 320373017328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 320373017329 active site 320373017330 phosphorylation site [posttranslational modification] 320373017331 intermolecular recognition site; other site 320373017332 dimerization interface [polypeptide binding]; other site 320373017333 Predicted flavoprotein [General function prediction only]; Region: COG0431 320373017334 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 320373017335 RNA polymerase sigma factor; Provisional; Region: PRK12545 320373017336 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 320373017337 DNA binding residues [nucleotide binding] 320373017338 Putative zinc-finger; Region: zf-HC2; pfam13490 320373017339 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 320373017340 ArsC family; Region: ArsC; pfam03960 320373017341 catalytic residues [active] 320373017342 ParA-like protein; Provisional; Region: PHA02518 320373017343 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 320373017344 P-loop; other site 320373017345 Magnesium ion binding site [ion binding]; other site 320373017346 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 320373017347 ParB-like nuclease domain; Region: ParB; smart00470 320373017348 Initiator Replication protein; Region: Rep_3; pfam01051