-- dump date 20140619_015905 -- class Genbank::misc_feature -- table misc_feature_note -- id note 266265000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 266265000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 266265000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265000004 Walker A motif; other site 266265000005 ATP binding site [chemical binding]; other site 266265000006 Walker B motif; other site 266265000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266265000008 arginine finger; other site 266265000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 266265000010 DnaA box-binding interface [nucleotide binding]; other site 266265000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 266265000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 266265000013 putative DNA binding surface [nucleotide binding]; other site 266265000014 dimer interface [polypeptide binding]; other site 266265000015 beta-clamp/clamp loader binding surface; other site 266265000016 beta-clamp/translesion DNA polymerase binding surface; other site 266265000017 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 266265000018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265000019 ATP binding site [chemical binding]; other site 266265000020 Mg2+ binding site [ion binding]; other site 266265000021 G-X-G motif; other site 266265000022 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266265000023 anchoring element; other site 266265000024 dimer interface [polypeptide binding]; other site 266265000025 ATP binding site [chemical binding]; other site 266265000026 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 266265000027 active site 266265000028 putative metal-binding site [ion binding]; other site 266265000029 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266265000030 Transposase domain (DUF772); Region: DUF772; pfam05598 266265000031 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265000032 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 266265000033 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265000034 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266265000035 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266265000036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265000037 ABC transporter signature motif; other site 266265000038 Walker B; other site 266265000039 D-loop; other site 266265000040 H-loop/switch region; other site 266265000041 Helix-turn-helix domain; Region: HTH_38; pfam13936 266265000042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266265000043 Integrase core domain; Region: rve; pfam00665 266265000044 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266265000045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265000046 Walker A motif; other site 266265000047 ATP binding site [chemical binding]; other site 266265000048 Walker B motif; other site 266265000049 arginine finger; other site 266265000050 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 266265000051 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 266265000052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265000053 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266265000054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265000055 putative substrate translocation pore; other site 266265000056 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265000057 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265000058 DNA-binding site [nucleotide binding]; DNA binding site 266265000059 FCD domain; Region: FCD; pfam07729 266265000060 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266265000061 galactarate dehydratase; Region: galactar-dH20; TIGR03248 266265000062 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266265000063 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265000064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265000065 DNA-binding site [nucleotide binding]; DNA binding site 266265000066 FCD domain; Region: FCD; pfam07729 266265000067 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 266265000068 ethanolamine permease; Region: 2A0305; TIGR00908 266265000069 hypothetical protein; Provisional; Region: PHA02764 266265000070 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 266265000071 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 266265000072 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 266265000073 Protein of unknown function (DUF779); Region: DUF779; pfam05610 266265000074 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 266265000075 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265000076 NAD(P) binding site [chemical binding]; other site 266265000077 catalytic residues [active] 266265000078 transcriptional regulator EutR; Provisional; Region: PRK10130 266265000079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265000080 Heavy-metal-associated domain; Region: HMA; pfam00403 266265000081 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 266265000082 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266265000083 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266265000084 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266265000085 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266265000086 DNA binding residues [nucleotide binding] 266265000087 dimer interface [polypeptide binding]; other site 266265000088 putative metal binding site [ion binding]; other site 266265000089 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 266265000090 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266265000091 ATP binding site [chemical binding]; other site 266265000092 Mg++ binding site [ion binding]; other site 266265000093 motif III; other site 266265000094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265000095 nucleotide binding region [chemical binding]; other site 266265000096 ATP-binding site [chemical binding]; other site 266265000097 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 266265000098 putative aminotransferase; Provisional; Region: PRK12414 266265000099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265000100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265000101 homodimer interface [polypeptide binding]; other site 266265000102 catalytic residue [active] 266265000103 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265000104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265000105 substrate binding pocket [chemical binding]; other site 266265000106 membrane-bound complex binding site; other site 266265000107 hinge residues; other site 266265000108 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 266265000109 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 266265000110 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 266265000111 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 266265000112 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 266265000113 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266265000114 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 266265000115 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 266265000116 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 266265000117 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 266265000118 RHS Repeat; Region: RHS_repeat; pfam05593 266265000119 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266265000120 RHS Repeat; Region: RHS_repeat; pfam05593 266265000121 RHS Repeat; Region: RHS_repeat; pfam05593 266265000122 RHS Repeat; Region: RHS_repeat; pfam05593 266265000123 RHS Repeat; Region: RHS_repeat; pfam05593 266265000124 RHS protein; Region: RHS; pfam03527 266265000125 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 266265000126 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 266265000127 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266265000128 CoenzymeA binding site [chemical binding]; other site 266265000129 subunit interaction site [polypeptide binding]; other site 266265000130 PHB binding site; other site 266265000131 Patatin-like phospholipase; Region: Patatin; pfam01734 266265000132 active site 266265000133 nucleophile elbow; other site 266265000134 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 266265000135 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266265000136 dimerization interface [polypeptide binding]; other site 266265000137 NAD binding site [chemical binding]; other site 266265000138 ligand binding site [chemical binding]; other site 266265000139 catalytic site [active] 266265000140 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 266265000141 active site 266265000142 substrate-binding site [chemical binding]; other site 266265000143 metal-binding site [ion binding] 266265000144 GTP binding site [chemical binding]; other site 266265000145 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265000146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265000147 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265000148 putative effector binding pocket; other site 266265000149 dimerization interface [polypeptide binding]; other site 266265000150 DNA topoisomerase III; Validated; Region: PRK08173 266265000151 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 266265000152 active site 266265000153 putative interdomain interaction site [polypeptide binding]; other site 266265000154 putative metal-binding site [ion binding]; other site 266265000155 putative nucleotide binding site [chemical binding]; other site 266265000156 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266265000157 domain I; other site 266265000158 DNA binding groove [nucleotide binding] 266265000159 phosphate binding site [ion binding]; other site 266265000160 domain II; other site 266265000161 domain III; other site 266265000162 nucleotide binding site [chemical binding]; other site 266265000163 catalytic site [active] 266265000164 domain IV; other site 266265000165 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 266265000166 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 266265000167 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266265000168 catalytic residues [active] 266265000169 DNA protecting protein DprA; Region: dprA; TIGR00732 266265000170 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 266265000171 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266265000172 active site 266265000173 catalytic residues [active] 266265000174 metal binding site [ion binding]; metal-binding site 266265000175 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 266265000176 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 266265000177 substrate binding site [chemical binding]; other site 266265000178 putative active site [active] 266265000179 putative cosubstrate binding site; other site 266265000180 catalytic site [active] 266265000181 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 266265000182 substrate binding site [chemical binding]; other site 266265000183 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265000184 M48 family peptidase; Provisional; Region: PRK03001 266265000185 16S rRNA methyltransferase B; Provisional; Region: PRK10901 266265000186 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 266265000187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265000188 S-adenosylmethionine binding site [chemical binding]; other site 266265000189 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 266265000190 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 266265000191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265000192 dimerization interface [polypeptide binding]; other site 266265000193 PAS domain; Region: PAS; smart00091 266265000194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265000195 dimer interface [polypeptide binding]; other site 266265000196 phosphorylation site [posttranslational modification] 266265000197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265000198 ATP binding site [chemical binding]; other site 266265000199 Mg2+ binding site [ion binding]; other site 266265000200 G-X-G motif; other site 266265000201 Response regulator receiver domain; Region: Response_reg; pfam00072 266265000202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265000203 active site 266265000204 phosphorylation site [posttranslational modification] 266265000205 intermolecular recognition site; other site 266265000206 dimerization interface [polypeptide binding]; other site 266265000207 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 266265000208 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 266265000209 Ligand Binding Site [chemical binding]; other site 266265000210 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 266265000211 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 266265000212 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 266265000213 active site 266265000214 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266265000215 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266265000216 Sel1-like repeats; Region: SEL1; smart00671 266265000217 Sel1-like repeats; Region: SEL1; smart00671 266265000218 Sel1-like repeats; Region: SEL1; smart00671 266265000219 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 266265000220 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 266265000221 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266265000222 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266265000223 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 266265000224 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 266265000225 rod shape-determining protein MreC; Region: MreC; pfam04085 266265000226 rod shape-determining protein MreB; Provisional; Region: PRK13927 266265000227 MreB and similar proteins; Region: MreB_like; cd10225 266265000228 nucleotide binding site [chemical binding]; other site 266265000229 Mg binding site [ion binding]; other site 266265000230 putative protofilament interaction site [polypeptide binding]; other site 266265000231 RodZ interaction site [polypeptide binding]; other site 266265000232 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 266265000233 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266265000234 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 266265000235 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 266265000236 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 266265000237 GatB domain; Region: GatB_Yqey; smart00845 266265000238 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 266265000239 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 266265000240 putative active site [active] 266265000241 putative catalytic site [active] 266265000242 putative DNA binding site [nucleotide binding]; other site 266265000243 putative phosphate binding site [ion binding]; other site 266265000244 metal binding site A [ion binding]; metal-binding site 266265000245 putative AP binding site [nucleotide binding]; other site 266265000246 putative metal binding site B [ion binding]; other site 266265000247 Peptidase family M48; Region: Peptidase_M48; cl12018 266265000248 muropeptide transporter; Reviewed; Region: ampG; PRK11902 266265000249 AmpG-like permease; Region: 2A0125; TIGR00901 266265000250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266265000251 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 266265000252 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 266265000253 division inhibitor protein; Provisional; Region: slmA; PRK09480 266265000254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265000255 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 266265000256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265000257 motif II; other site 266265000258 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 266265000259 feedback inhibition sensing region; other site 266265000260 homohexameric interface [polypeptide binding]; other site 266265000261 nucleotide binding site [chemical binding]; other site 266265000262 N-acetyl-L-glutamate binding site [chemical binding]; other site 266265000263 TPR repeat; Region: TPR_11; pfam13414 266265000264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265000265 binding surface 266265000266 TPR motif; other site 266265000267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265000268 TPR repeat; Region: TPR_11; pfam13414 266265000269 binding surface 266265000270 TPR motif; other site 266265000271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265000272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265000273 dimer interface [polypeptide binding]; other site 266265000274 phosphorylation site [posttranslational modification] 266265000275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265000276 ATP binding site [chemical binding]; other site 266265000277 Mg2+ binding site [ion binding]; other site 266265000278 G-X-G motif; other site 266265000279 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 266265000280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265000281 active site 266265000282 phosphorylation site [posttranslational modification] 266265000283 intermolecular recognition site; other site 266265000284 dimerization interface [polypeptide binding]; other site 266265000285 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265000286 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 266265000287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265000288 Walker A motif; other site 266265000289 ATP binding site [chemical binding]; other site 266265000290 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 266265000291 Walker B motif; other site 266265000292 arginine finger; other site 266265000293 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266265000294 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 266265000295 active site 266265000296 HslU subunit interaction site [polypeptide binding]; other site 266265000297 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 266265000298 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266265000299 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 266265000300 P-loop, Walker A motif; other site 266265000301 Base recognition motif; other site 266265000302 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266265000303 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 266265000304 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 266265000305 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 266265000306 putative RNA binding site [nucleotide binding]; other site 266265000307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265000308 S-adenosylmethionine binding site [chemical binding]; other site 266265000309 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 266265000310 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266265000311 active site 266265000312 DNA binding site [nucleotide binding] 266265000313 Int/Topo IB signature motif; other site 266265000314 Protein of unknown function, DUF484; Region: DUF484; cl17449 266265000315 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 266265000316 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266265000317 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 266265000318 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266265000319 putative acyl-acceptor binding pocket; other site 266265000320 S-adenosylmethionine synthetase; Validated; Region: PRK05250 266265000321 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 266265000322 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 266265000323 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 266265000324 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 266265000325 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 266265000326 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265000327 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265000328 active site 266265000329 catalytic tetrad [active] 266265000330 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266265000331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265000332 putative substrate translocation pore; other site 266265000333 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265000334 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265000335 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265000336 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266265000337 serine/threonine protein kinase; Provisional; Region: PRK11768 266265000338 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 266265000339 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 266265000340 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266265000341 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266265000342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 266265000343 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 266265000344 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266265000345 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266265000346 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 266265000347 putative hydrophobic ligand binding site [chemical binding]; other site 266265000348 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 266265000349 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266265000350 metal ion-dependent adhesion site (MIDAS); other site 266265000351 MoxR-like ATPases [General function prediction only]; Region: COG0714 266265000352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265000353 Walker A motif; other site 266265000354 ATP binding site [chemical binding]; other site 266265000355 Walker B motif; other site 266265000356 arginine finger; other site 266265000357 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265000358 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266265000359 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265000360 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265000361 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265000362 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265000363 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 266265000364 catalytic loop [active] 266265000365 iron binding site [ion binding]; other site 266265000366 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265000367 Winged helix-turn helix; Region: HTH_29; pfam13551 266265000368 Helix-turn-helix domain; Region: HTH_28; pfam13518 266265000369 Homeodomain-like domain; Region: HTH_32; pfam13565 266265000370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266265000371 Integrase core domain; Region: rve; pfam00665 266265000372 Integrase core domain; Region: rve_3; pfam13683 266265000373 Winged helix-turn helix; Region: HTH_29; pfam13551 266265000374 Helix-turn-helix domain; Region: HTH_28; pfam13518 266265000375 Homeodomain-like domain; Region: HTH_32; pfam13565 266265000376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266265000377 Integrase core domain; Region: rve; pfam00665 266265000378 Integrase core domain; Region: rve_3; pfam13683 266265000379 amino acid transporter; Region: 2A0306; TIGR00909 266265000380 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 266265000381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265000382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265000383 active site 266265000384 phosphorylation site [posttranslational modification] 266265000385 intermolecular recognition site; other site 266265000386 dimerization interface [polypeptide binding]; other site 266265000387 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265000388 DNA binding residues [nucleotide binding] 266265000389 dimerization interface [polypeptide binding]; other site 266265000390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266265000391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265000392 ATP binding site [chemical binding]; other site 266265000393 Mg2+ binding site [ion binding]; other site 266265000394 G-X-G motif; other site 266265000395 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265000396 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 266265000397 FAD binding pocket [chemical binding]; other site 266265000398 FAD binding motif [chemical binding]; other site 266265000399 phosphate binding motif [ion binding]; other site 266265000400 beta-alpha-beta structure motif; other site 266265000401 NAD binding pocket [chemical binding]; other site 266265000402 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265000403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265000404 TM-ABC transporter signature motif; other site 266265000405 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265000406 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265000407 TM-ABC transporter signature motif; other site 266265000408 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265000409 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265000410 Walker A/P-loop; other site 266265000411 ATP binding site [chemical binding]; other site 266265000412 Q-loop/lid; other site 266265000413 ABC transporter signature motif; other site 266265000414 Walker B; other site 266265000415 D-loop; other site 266265000416 H-loop/switch region; other site 266265000417 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265000418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266265000419 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 266265000420 putative ligand binding site [chemical binding]; other site 266265000421 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265000422 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265000423 DNA binding site [nucleotide binding] 266265000424 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 266265000425 putative dimerization interface [polypeptide binding]; other site 266265000426 putative ligand binding site [chemical binding]; other site 266265000427 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 266265000428 active site 266265000429 catalytic residues [active] 266265000430 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266265000431 putative phosphate binding site [ion binding]; other site 266265000432 putative catalytic site [active] 266265000433 putative phosphate binding site [ion binding]; other site 266265000434 putative metal binding site [ion binding]; other site 266265000435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265000436 Walker A motif; other site 266265000437 ATP binding site [chemical binding]; other site 266265000438 Walker B motif; other site 266265000439 arginine finger; other site 266265000440 Predicted dehydrogenase [General function prediction only]; Region: COG0579 266265000441 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265000442 High potential iron-sulfur protein; Region: HIPIP; pfam01355 266265000443 citrate-proton symporter; Provisional; Region: PRK15075 266265000444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265000445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265000446 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266265000447 Amidase; Region: Amidase; cl11426 266265000448 Dienelactone hydrolase family; Region: DLH; pfam01738 266265000449 Nitronate monooxygenase; Region: NMO; pfam03060 266265000450 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266265000451 FMN binding site [chemical binding]; other site 266265000452 substrate binding site [chemical binding]; other site 266265000453 putative catalytic residue [active] 266265000454 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265000455 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266265000456 dimerization interface [polypeptide binding]; other site 266265000457 ligand binding site [chemical binding]; other site 266265000458 Cupin-like domain; Region: Cupin_8; pfam13621 266265000459 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 266265000460 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 266265000461 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266265000462 MULE transposase domain; Region: MULE; pfam10551 266265000463 H-NS histone family; Region: Histone_HNS; pfam00816 266265000464 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266265000465 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266265000466 Cation efflux family; Region: Cation_efflux; pfam01545 266265000467 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265000468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265000469 putative DNA binding site [nucleotide binding]; other site 266265000470 putative Zn2+ binding site [ion binding]; other site 266265000471 AsnC family; Region: AsnC_trans_reg; pfam01037 266265000472 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 266265000473 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266265000474 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 266265000475 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 266265000476 Predicted methyltransferases [General function prediction only]; Region: COG0313 266265000477 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 266265000478 putative SAM binding site [chemical binding]; other site 266265000479 putative homodimer interface [polypeptide binding]; other site 266265000480 hypothetical protein; Provisional; Region: PRK14673 266265000481 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 266265000482 dimer interface [polypeptide binding]; other site 266265000483 active site 266265000484 outer membrane lipoprotein; Provisional; Region: PRK11023 266265000485 BON domain; Region: BON; pfam04972 266265000486 Cytochrome c551/c552 [Energy production and conversion]; Region: COG4654 266265000487 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 266265000488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265000489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265000490 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265000491 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266265000492 active site 266265000493 metal binding site [ion binding]; metal-binding site 266265000494 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266265000495 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266265000496 inhibitor site; inhibition site 266265000497 active site 266265000498 dimer interface [polypeptide binding]; other site 266265000499 catalytic residue [active] 266265000500 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 266265000501 intersubunit interface [polypeptide binding]; other site 266265000502 active site 266265000503 Zn2+ binding site [ion binding]; other site 266265000504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265000505 DNA-binding site [nucleotide binding]; DNA binding site 266265000506 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265000507 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265000508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265000509 homodimer interface [polypeptide binding]; other site 266265000510 catalytic residue [active] 266265000511 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266265000512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265000513 dimerization interface [polypeptide binding]; other site 266265000514 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265000515 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265000516 dimer interface [polypeptide binding]; other site 266265000517 putative CheW interface [polypeptide binding]; other site 266265000518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265000519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265000520 short chain dehydrogenase; Provisional; Region: PRK06180 266265000521 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265000522 NADP binding site [chemical binding]; other site 266265000523 active site 266265000524 steroid binding site; other site 266265000525 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266265000526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265000527 NAD(P) binding site [chemical binding]; other site 266265000528 active site 266265000529 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265000530 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265000531 metal binding site [ion binding]; metal-binding site 266265000532 active site 266265000533 I-site; other site 266265000534 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265000535 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266265000536 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266265000537 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 266265000538 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 266265000539 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265000540 CutC family; Region: CutC; cl01218 266265000541 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 266265000542 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266265000543 dimer interface [polypeptide binding]; other site 266265000544 PYR/PP interface [polypeptide binding]; other site 266265000545 TPP binding site [chemical binding]; other site 266265000546 substrate binding site [chemical binding]; other site 266265000547 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266265000548 TPP-binding site [chemical binding]; other site 266265000549 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 266265000550 Inward rectifier potassium channel; Region: IRK; pfam01007 266265000551 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 266265000552 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265000553 putative substrate binding site [chemical binding]; other site 266265000554 putative ATP binding site [chemical binding]; other site 266265000555 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 266265000556 dimerization interface [polypeptide binding]; other site 266265000557 putative active cleft [active] 266265000558 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265000559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265000560 DNA binding site [nucleotide binding] 266265000561 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 266265000562 ligand binding site [chemical binding]; other site 266265000563 dimerization interface [polypeptide binding]; other site 266265000564 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265000565 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 266265000566 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265000567 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265000568 metal binding site [ion binding]; metal-binding site 266265000569 active site 266265000570 I-site; other site 266265000571 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 266265000572 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 266265000573 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265000574 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265000575 trimer interface [polypeptide binding]; other site 266265000576 eyelet of channel; other site 266265000577 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265000578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265000579 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265000580 putative effector binding pocket; other site 266265000581 dimerization interface [polypeptide binding]; other site 266265000582 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 266265000583 B12 binding site [chemical binding]; other site 266265000584 cobalt ligand [ion binding]; other site 266265000585 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 266265000586 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 266265000587 Walker A; other site 266265000588 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 266265000589 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266265000590 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266265000591 FMN binding site [chemical binding]; other site 266265000592 substrate binding site [chemical binding]; other site 266265000593 putative catalytic residue [active] 266265000594 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266265000595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266265000596 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266265000597 active site 266265000598 catalytic site [active] 266265000599 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 266265000600 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 266265000601 putative deacylase active site [active] 266265000602 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 266265000603 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 266265000604 active site 266265000605 catalytic residues [active] 266265000606 metal binding site [ion binding]; metal-binding site 266265000607 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 266265000608 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 266265000609 putative ligand binding site [chemical binding]; other site 266265000610 NAD binding site [chemical binding]; other site 266265000611 dimerization interface [polypeptide binding]; other site 266265000612 catalytic site [active] 266265000613 Serine hydrolase; Region: Ser_hydrolase; pfam06821 266265000614 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265000615 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 266265000616 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266265000617 biotin synthase; Region: bioB; TIGR00433 266265000618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265000619 FeS/SAM binding site; other site 266265000620 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 266265000621 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 266265000622 AAA domain; Region: AAA_26; pfam13500 266265000623 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 266265000624 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 266265000625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265000626 catalytic residue [active] 266265000627 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 266265000628 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265000629 inhibitor-cofactor binding pocket; inhibition site 266265000630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265000631 catalytic residue [active] 266265000632 Winged helix-turn helix; Region: HTH_29; pfam13551 266265000633 Helix-turn-helix domain; Region: HTH_28; pfam13518 266265000634 Homeodomain-like domain; Region: HTH_32; pfam13565 266265000635 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266265000636 Integrase core domain; Region: rve; pfam00665 266265000637 Integrase core domain; Region: rve_3; pfam13683 266265000638 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266265000639 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265000640 hypothetical protein; Provisional; Region: PRK01842 266265000641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265000642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265000643 active site 266265000644 C factor cell-cell signaling protein; Provisional; Region: PRK09009 266265000645 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 266265000646 NADP binding site [chemical binding]; other site 266265000647 homodimer interface [polypeptide binding]; other site 266265000648 active site 266265000649 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 266265000650 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265000651 dimer interface [polypeptide binding]; other site 266265000652 active site 266265000653 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 266265000654 active site clefts [active] 266265000655 zinc binding site [ion binding]; other site 266265000656 dimer interface [polypeptide binding]; other site 266265000657 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 266265000658 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 266265000659 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 266265000660 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266265000661 DNA binding residues [nucleotide binding] 266265000662 putative dimer interface [polypeptide binding]; other site 266265000663 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266265000664 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265000665 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 266265000666 peptide binding site [polypeptide binding]; other site 266265000667 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 266265000668 cobalamin binding residues [chemical binding]; other site 266265000669 putative BtuC binding residues; other site 266265000670 dimer interface [polypeptide binding]; other site 266265000671 short chain dehydrogenase; Provisional; Region: PRK07024 266265000672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265000673 NAD(P) binding site [chemical binding]; other site 266265000674 active site 266265000675 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 266265000676 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266265000677 catalytic residues [active] 266265000678 hinge region; other site 266265000679 alpha helical domain; other site 266265000680 Sporulation related domain; Region: SPOR; pfam05036 266265000681 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 266265000682 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 266265000683 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 266265000684 active site 266265000685 HIGH motif; other site 266265000686 KMSK motif region; other site 266265000687 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 266265000688 tRNA binding surface [nucleotide binding]; other site 266265000689 anticodon binding site; other site 266265000690 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 266265000691 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 266265000692 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 266265000693 substrate binding pocket [chemical binding]; other site 266265000694 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 266265000695 B12 binding site [chemical binding]; other site 266265000696 cobalt ligand [ion binding]; other site 266265000697 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 266265000698 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 266265000699 Predicted ATPase [General function prediction only]; Region: COG4637 266265000700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265000701 Walker A/P-loop; other site 266265000702 ATP binding site [chemical binding]; other site 266265000703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265000704 ABC transporter signature motif; other site 266265000705 Walker B; other site 266265000706 D-loop; other site 266265000707 H-loop/switch region; other site 266265000708 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 266265000709 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 266265000710 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 266265000711 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266265000712 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 266265000713 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265000714 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265000715 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265000716 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265000717 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265000718 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 266265000719 putative ligand binding site [chemical binding]; other site 266265000720 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265000721 substrate binding site [chemical binding]; other site 266265000722 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 266265000723 oxyanion hole (OAH) forming residues; other site 266265000724 trimer interface [polypeptide binding]; other site 266265000725 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266265000726 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 266265000727 dinuclear metal binding motif [ion binding]; other site 266265000728 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 266265000729 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 266265000730 active site 266265000731 HIGH motif; other site 266265000732 nucleotide binding site [chemical binding]; other site 266265000733 pantothenate kinase; Reviewed; Region: PRK13328 266265000734 biotin--protein ligase; Provisional; Region: PRK06955 266265000735 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 266265000736 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 266265000737 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 266265000738 Permease; Region: Permease; pfam02405 266265000739 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 266265000740 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 266265000741 Walker A/P-loop; other site 266265000742 ATP binding site [chemical binding]; other site 266265000743 Q-loop/lid; other site 266265000744 ABC transporter signature motif; other site 266265000745 Walker B; other site 266265000746 D-loop; other site 266265000747 H-loop/switch region; other site 266265000748 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 266265000749 mce related protein; Region: MCE; pfam02470 266265000750 Protein of unknown function (DUF330); Region: DUF330; cl01135 266265000751 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 266265000752 dimer interface [polypeptide binding]; other site 266265000753 [2Fe-2S] cluster binding site [ion binding]; other site 266265000754 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 266265000755 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 266265000756 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266265000757 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 266265000758 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266265000759 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 266265000760 homodimer interface [polypeptide binding]; other site 266265000761 substrate-cofactor binding pocket; other site 266265000762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265000763 catalytic residue [active] 266265000764 Protein of unknown function (DUF493); Region: DUF493; cl01102 266265000765 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265000766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265000767 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265000768 dimerization interface [polypeptide binding]; other site 266265000769 substrate binding pocket [chemical binding]; other site 266265000770 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 266265000771 lipoate-protein ligase B; Provisional; Region: PRK14343 266265000772 lipoyl synthase; Provisional; Region: PRK05481 266265000773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265000774 FeS/SAM binding site; other site 266265000775 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 266265000776 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265000777 substrate binding pocket [chemical binding]; other site 266265000778 membrane-bound complex binding site; other site 266265000779 hinge residues; other site 266265000780 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265000781 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265000782 Walker A/P-loop; other site 266265000783 ATP binding site [chemical binding]; other site 266265000784 Q-loop/lid; other site 266265000785 ABC transporter signature motif; other site 266265000786 Walker B; other site 266265000787 D-loop; other site 266265000788 H-loop/switch region; other site 266265000789 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265000790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265000791 dimer interface [polypeptide binding]; other site 266265000792 conserved gate region; other site 266265000793 putative PBP binding loops; other site 266265000794 ABC-ATPase subunit interface; other site 266265000795 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266265000796 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 266265000797 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 266265000798 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 266265000799 PhoU domain; Region: PhoU; pfam01895 266265000800 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266265000801 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266265000802 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266265000803 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 266265000804 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 266265000805 putative active site [active] 266265000806 catalytic site [active] 266265000807 putative metal binding site [ion binding]; other site 266265000808 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265000809 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265000810 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265000811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265000812 dimer interface [polypeptide binding]; other site 266265000813 conserved gate region; other site 266265000814 putative PBP binding loops; other site 266265000815 ABC-ATPase subunit interface; other site 266265000816 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265000817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266265000818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265000819 dimer interface [polypeptide binding]; other site 266265000820 ABC-ATPase subunit interface; other site 266265000821 putative PBP binding loops; other site 266265000822 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265000823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265000824 Walker A/P-loop; other site 266265000825 ATP binding site [chemical binding]; other site 266265000826 Q-loop/lid; other site 266265000827 ABC transporter signature motif; other site 266265000828 Walker B; other site 266265000829 D-loop; other site 266265000830 H-loop/switch region; other site 266265000831 TOBE domain; Region: TOBE_2; pfam08402 266265000832 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 266265000833 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266265000834 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266265000835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265000836 dimer interface [polypeptide binding]; other site 266265000837 phosphorylation site [posttranslational modification] 266265000838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265000839 ATP binding site [chemical binding]; other site 266265000840 Mg2+ binding site [ion binding]; other site 266265000841 G-X-G motif; other site 266265000842 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266265000843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265000844 active site 266265000845 phosphorylation site [posttranslational modification] 266265000846 intermolecular recognition site; other site 266265000847 dimerization interface [polypeptide binding]; other site 266265000848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265000849 Walker A motif; other site 266265000850 ATP binding site [chemical binding]; other site 266265000851 Walker B motif; other site 266265000852 arginine finger; other site 266265000853 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265000854 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266265000855 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266265000856 catalytic residues [active] 266265000857 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 266265000858 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266265000859 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 266265000860 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 266265000861 Membrane fusogenic activity; Region: BMFP; pfam04380 266265000862 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 266265000863 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266265000864 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 266265000865 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 266265000866 Glutamate-cysteine ligase; Region: GshA; pfam08886 266265000867 glutathione synthetase; Provisional; Region: PRK05246 266265000868 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 266265000869 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 266265000870 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 266265000871 active pocket/dimerization site; other site 266265000872 active site 266265000873 phosphorylation site [posttranslational modification] 266265000874 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266265000875 dimerization domain swap beta strand [polypeptide binding]; other site 266265000876 regulatory protein interface [polypeptide binding]; other site 266265000877 active site 266265000878 regulatory phosphorylation site [posttranslational modification]; other site 266265000879 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266265000880 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266265000881 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266265000882 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266265000883 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 266265000884 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 266265000885 ATP binding site [chemical binding]; other site 266265000886 substrate interface [chemical binding]; other site 266265000887 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 266265000888 C-terminal peptidase (prc); Region: prc; TIGR00225 266265000889 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 266265000890 protein binding site [polypeptide binding]; other site 266265000891 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 266265000892 Catalytic dyad [active] 266265000893 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266265000894 catalytic core [active] 266265000895 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266265000896 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266265000897 active site residue [active] 266265000898 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 266265000899 GSH binding site [chemical binding]; other site 266265000900 catalytic residues [active] 266265000901 preprotein translocase subunit SecB; Validated; Region: PRK05751 266265000902 SecA binding site; other site 266265000903 Preprotein binding site; other site 266265000904 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 266265000905 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266265000906 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 266265000907 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 266265000908 putative ADP-ribose binding site [chemical binding]; other site 266265000909 putative active site [active] 266265000910 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 266265000911 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 266265000912 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265000913 active site 266265000914 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 266265000915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265000916 S-adenosylmethionine binding site [chemical binding]; other site 266265000917 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 266265000918 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 266265000919 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 266265000920 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266265000921 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265000922 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266265000923 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266265000924 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265000925 ligand binding site [chemical binding]; other site 266265000926 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266265000927 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 266265000928 Subunit I/III interface [polypeptide binding]; other site 266265000929 D-pathway; other site 266265000930 Subunit I/VIIc interface [polypeptide binding]; other site 266265000931 Subunit I/IV interface [polypeptide binding]; other site 266265000932 Subunit I/II interface [polypeptide binding]; other site 266265000933 Low-spin heme (heme a) binding site [chemical binding]; other site 266265000934 Subunit I/VIIa interface [polypeptide binding]; other site 266265000935 Subunit I/VIa interface [polypeptide binding]; other site 266265000936 Dimer interface; other site 266265000937 Putative water exit pathway; other site 266265000938 Binuclear center (heme a3/CuB) [ion binding]; other site 266265000939 K-pathway; other site 266265000940 Subunit I/Vb interface [polypeptide binding]; other site 266265000941 Putative proton exit pathway; other site 266265000942 Subunit I/VIb interface; other site 266265000943 Subunit I/VIc interface [polypeptide binding]; other site 266265000944 Electron transfer pathway; other site 266265000945 Subunit I/VIIIb interface [polypeptide binding]; other site 266265000946 Subunit I/VIIb interface [polypeptide binding]; other site 266265000947 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 266265000948 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 266265000949 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 266265000950 Subunit III/VIIa interface [polypeptide binding]; other site 266265000951 Phospholipid binding site [chemical binding]; other site 266265000952 Subunit I/III interface [polypeptide binding]; other site 266265000953 Subunit III/VIb interface [polypeptide binding]; other site 266265000954 Subunit III/VIa interface; other site 266265000955 Subunit III/Vb interface [polypeptide binding]; other site 266265000956 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 266265000957 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 266265000958 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266265000959 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 266265000960 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 266265000961 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 266265000962 UbiA prenyltransferase family; Region: UbiA; pfam01040 266265000963 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 266265000964 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266265000965 Cu(I) binding site [ion binding]; other site 266265000966 YCII-related domain; Region: YCII; cl00999 266265000967 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 266265000968 HAMP domain; Region: HAMP; pfam00672 266265000969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265000970 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265000971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265000972 dimer interface [polypeptide binding]; other site 266265000973 putative CheW interface [polypeptide binding]; other site 266265000974 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266265000975 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266265000976 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265000977 MarR family; Region: MarR_2; pfam12802 266265000978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265000979 Coenzyme A binding pocket [chemical binding]; other site 266265000980 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266265000981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265000982 DNA-binding site [nucleotide binding]; DNA binding site 266265000983 UTRA domain; Region: UTRA; pfam07702 266265000984 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 266265000985 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 266265000986 active site 266265000987 dimer interface [polypeptide binding]; other site 266265000988 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 266265000989 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266265000990 dimer interface [polypeptide binding]; other site 266265000991 active site 266265000992 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266265000993 dimer interface [polypeptide binding]; other site 266265000994 active site 266265000995 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 266265000996 HPr interaction site; other site 266265000997 glycerol kinase (GK) interaction site [polypeptide binding]; other site 266265000998 active site 266265000999 phosphorylation site [posttranslational modification] 266265001000 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 266265001001 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 266265001002 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266265001003 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266265001004 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 266265001005 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 266265001006 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 266265001007 active site turn [active] 266265001008 phosphorylation site [posttranslational modification] 266265001009 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 266265001010 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 266265001011 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266265001012 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266265001013 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 266265001014 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 266265001015 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 266265001016 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266265001017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265001018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265001019 DNA binding residues [nucleotide binding] 266265001020 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 266265001021 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 266265001022 glycosyl transferase family protein; Provisional; Region: PRK08136 266265001023 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266265001024 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265001025 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265001026 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266265001027 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266265001028 C-terminal domain interface [polypeptide binding]; other site 266265001029 GSH binding site (G-site) [chemical binding]; other site 266265001030 putative dimer interface [polypeptide binding]; other site 266265001031 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266265001032 dimer interface [polypeptide binding]; other site 266265001033 N-terminal domain interface [polypeptide binding]; other site 266265001034 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266265001035 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 266265001036 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 266265001037 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266265001038 P loop; other site 266265001039 GTP binding site [chemical binding]; other site 266265001040 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 266265001041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265001042 S-adenosylmethionine binding site [chemical binding]; other site 266265001043 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 266265001044 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 266265001045 active site 266265001046 (T/H)XGH motif; other site 266265001047 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 266265001048 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 266265001049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265001050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265001051 homodimer interface [polypeptide binding]; other site 266265001052 catalytic residue [active] 266265001053 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 266265001054 putative active site [active] 266265001055 catalytic residue [active] 266265001056 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 266265001057 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 266265001058 5S rRNA interface [nucleotide binding]; other site 266265001059 CTC domain interface [polypeptide binding]; other site 266265001060 L16 interface [polypeptide binding]; other site 266265001061 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 266265001062 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 266265001063 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265001064 active site 266265001065 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 266265001066 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 266265001067 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 266265001068 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 266265001069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265001070 TPR motif; other site 266265001071 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 266265001072 binding surface 266265001073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265001074 TPR motif; other site 266265001075 binding surface 266265001076 TPR repeat; Region: TPR_11; pfam13414 266265001077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265001078 binding surface 266265001079 TPR motif; other site 266265001080 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 266265001081 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 266265001082 DNA binding site [nucleotide binding] 266265001083 catalytic residue [active] 266265001084 H2TH interface [polypeptide binding]; other site 266265001085 putative catalytic residues [active] 266265001086 turnover-facilitating residue; other site 266265001087 intercalation triad [nucleotide binding]; other site 266265001088 8OG recognition residue [nucleotide binding]; other site 266265001089 putative reading head residues; other site 266265001090 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 266265001091 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266265001092 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 266265001093 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266265001094 minor groove reading motif; other site 266265001095 helix-hairpin-helix signature motif; other site 266265001096 substrate binding pocket [chemical binding]; other site 266265001097 active site 266265001098 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 266265001099 DNA binding and oxoG recognition site [nucleotide binding] 266265001100 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 266265001101 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 266265001102 AAA domain; Region: AAA_18; pfam13238 266265001103 HPr kinase/phosphorylase; Provisional; Region: PRK05428 266265001104 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 266265001105 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 266265001106 Hpr binding site; other site 266265001107 active site 266265001108 homohexamer subunit interaction site [polypeptide binding]; other site 266265001109 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 266265001110 active site 266265001111 phosphorylation site [posttranslational modification] 266265001112 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 266265001113 30S subunit binding site; other site 266265001114 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 266265001115 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266265001116 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266265001117 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 266265001118 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 266265001119 Walker A/P-loop; other site 266265001120 ATP binding site [chemical binding]; other site 266265001121 Q-loop/lid; other site 266265001122 ABC transporter signature motif; other site 266265001123 Walker B; other site 266265001124 D-loop; other site 266265001125 H-loop/switch region; other site 266265001126 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 266265001127 OstA-like protein; Region: OstA; pfam03968 266265001128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 266265001129 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 266265001130 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 266265001131 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 266265001132 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 266265001133 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 266265001134 putative active site [active] 266265001135 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 266265001136 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 266265001137 putative cation:proton antiport protein; Provisional; Region: PRK10669 266265001138 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 266265001139 TrkA-N domain; Region: TrkA_N; pfam02254 266265001140 TrkA-C domain; Region: TrkA_C; pfam02080 266265001141 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265001142 active site 266265001143 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265001144 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 266265001145 nudix motif; other site 266265001146 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 266265001147 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 266265001148 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 266265001149 putative active site [active] 266265001150 putative substrate binding site [chemical binding]; other site 266265001151 putative cosubstrate binding site; other site 266265001152 catalytic site [active] 266265001153 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 266265001154 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 266265001155 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 266265001156 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266265001157 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 266265001158 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266265001159 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266265001160 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266265001161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001162 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265001163 putative substrate translocation pore; other site 266265001164 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266265001165 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266265001166 dimer interface [polypeptide binding]; other site 266265001167 ssDNA binding site [nucleotide binding]; other site 266265001168 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266265001169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001170 D-galactonate transporter; Region: 2A0114; TIGR00893 266265001171 putative substrate translocation pore; other site 266265001172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265001173 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266265001174 active site 266265001175 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266265001176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265001177 DNA-binding site [nucleotide binding]; DNA binding site 266265001178 UTRA domain; Region: UTRA; pfam07702 266265001179 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266265001180 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266265001181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265001182 DNA-binding site [nucleotide binding]; DNA binding site 266265001183 FCD domain; Region: FCD; pfam07729 266265001184 putative sialic acid transporter; Region: 2A0112; TIGR00891 266265001185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001186 putative substrate translocation pore; other site 266265001187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001188 D-galactonate transporter; Region: 2A0114; TIGR00893 266265001189 putative substrate translocation pore; other site 266265001190 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265001191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265001192 NAD(P) binding site [chemical binding]; other site 266265001193 active site 266265001194 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265001195 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265001196 trimer interface [polypeptide binding]; other site 266265001197 eyelet of channel; other site 266265001198 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265001199 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265001200 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266265001201 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266265001202 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265001203 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 266265001204 Domain of unknown function (DUF336); Region: DUF336; pfam03928 266265001205 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266265001206 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266265001207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265001210 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266265001211 DNA-binding site [nucleotide binding]; DNA binding site 266265001212 FCD domain; Region: FCD; pfam07729 266265001213 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266265001214 putative active site [active] 266265001215 putative catalytic site [active] 266265001216 benzoate transport; Region: 2A0115; TIGR00895 266265001217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001218 putative substrate translocation pore; other site 266265001219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001220 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266265001221 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265001222 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265001223 active site 266265001224 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265001225 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265001226 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266265001227 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265001228 DNA-binding site [nucleotide binding]; DNA binding site 266265001229 UTRA domain; Region: UTRA; pfam07702 266265001230 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266265001231 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 266265001232 Tar ligand binding domain homologue; Region: TarH; pfam02203 266265001233 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265001234 dimerization interface [polypeptide binding]; other site 266265001235 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265001236 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265001237 dimer interface [polypeptide binding]; other site 266265001238 putative CheW interface [polypeptide binding]; other site 266265001239 Cytochrome c; Region: Cytochrom_C; cl11414 266265001240 Cytochrome c; Region: Cytochrom_C; cl11414 266265001241 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 266265001242 Low-spin heme binding site [chemical binding]; other site 266265001243 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 266265001244 Subunit I/II interface [polypeptide binding]; other site 266265001245 Putative Q-pathway; other site 266265001246 Putative D-pathway homolog; other site 266265001247 Putative alternate electron transfer pathway; other site 266265001248 Putative water exit pathway; other site 266265001249 Binuclear center (active site) [active] 266265001250 Putative K-pathway homolog; other site 266265001251 Putative proton exit pathway; other site 266265001252 Subunit I/IIa interface [polypeptide binding]; other site 266265001253 Electron transfer pathway; other site 266265001254 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266265001255 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265001256 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265001257 Cytochrome c; Region: Cytochrom_C; pfam00034 266265001258 Cytochrome c; Region: Cytochrom_C; cl11414 266265001259 Cytochrome c; Region: Cytochrom_C; cl11414 266265001260 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265001261 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265001262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265001263 dimerization interface [polypeptide binding]; other site 266265001264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265001265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001266 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265001267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265001268 active site 266265001269 phosphorylation site [posttranslational modification] 266265001270 intermolecular recognition site; other site 266265001271 dimerization interface [polypeptide binding]; other site 266265001272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265001273 dimerization interface [polypeptide binding]; other site 266265001274 DNA binding residues [nucleotide binding] 266265001275 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265001276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265001277 active site 266265001278 phosphorylation site [posttranslational modification] 266265001279 intermolecular recognition site; other site 266265001280 dimerization interface [polypeptide binding]; other site 266265001281 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265001282 DNA binding residues [nucleotide binding] 266265001283 dimerization interface [polypeptide binding]; other site 266265001284 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265001285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265001286 active site 266265001287 phosphorylation site [posttranslational modification] 266265001288 intermolecular recognition site; other site 266265001289 dimerization interface [polypeptide binding]; other site 266265001290 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265001291 DNA binding residues [nucleotide binding] 266265001292 dimerization interface [polypeptide binding]; other site 266265001293 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 266265001294 amphipathic channel; other site 266265001295 Asn-Pro-Ala signature motifs; other site 266265001296 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265001297 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265001298 substrate binding pocket [chemical binding]; other site 266265001299 membrane-bound complex binding site; other site 266265001300 hinge residues; other site 266265001301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265001302 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265001303 substrate binding pocket [chemical binding]; other site 266265001304 membrane-bound complex binding site; other site 266265001305 hinge residues; other site 266265001306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265001307 PAS domain; Region: PAS_9; pfam13426 266265001308 putative active site [active] 266265001309 heme pocket [chemical binding]; other site 266265001310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265001311 dimer interface [polypeptide binding]; other site 266265001312 phosphorylation site [posttranslational modification] 266265001313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265001314 ATP binding site [chemical binding]; other site 266265001315 Mg2+ binding site [ion binding]; other site 266265001316 G-X-G motif; other site 266265001317 Response regulator receiver domain; Region: Response_reg; pfam00072 266265001318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265001319 active site 266265001320 phosphorylation site [posttranslational modification] 266265001321 intermolecular recognition site; other site 266265001322 dimerization interface [polypeptide binding]; other site 266265001323 CHRD domain; Region: CHRD; pfam07452 266265001324 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265001325 EcsC protein family; Region: EcsC; pfam12787 266265001326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001327 putative substrate translocation pore; other site 266265001328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001329 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265001330 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 266265001331 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266265001332 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 266265001333 dimer interface [polypeptide binding]; other site 266265001334 active site 266265001335 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266265001336 substrate binding site [chemical binding]; other site 266265001337 catalytic residue [active] 266265001338 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266265001339 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265001340 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266265001341 putative active site [active] 266265001342 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 266265001343 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265001344 active site 266265001345 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265001346 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266265001347 homotrimer interaction site [polypeptide binding]; other site 266265001348 putative active site [active] 266265001349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 266265001350 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 266265001351 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 266265001352 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 266265001353 threonine dehydratase; Reviewed; Region: PRK09224 266265001354 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266265001355 tetramer interface [polypeptide binding]; other site 266265001356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265001357 catalytic residue [active] 266265001358 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 266265001359 putative Ile/Val binding site [chemical binding]; other site 266265001360 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 266265001361 putative Ile/Val binding site [chemical binding]; other site 266265001362 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 266265001363 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265001364 FAD binding domain; Region: FAD_binding_4; pfam01565 266265001365 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265001366 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 266265001367 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266265001368 Cysteine-rich domain; Region: CCG; pfam02754 266265001369 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 266265001370 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 266265001371 nucleotide binding site/active site [active] 266265001372 HIT family signature motif; other site 266265001373 catalytic residue [active] 266265001374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 266265001375 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 266265001376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265001377 S-adenosylmethionine binding site [chemical binding]; other site 266265001378 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 266265001379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 266265001380 SCP-2 sterol transfer family; Region: SCP2; pfam02036 266265001381 Membrane fusogenic activity; Region: BMFP; cl01115 266265001382 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 266265001383 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 266265001384 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 266265001385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266265001386 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 266265001387 Uncharacterized conserved protein [Function unknown]; Region: COG2928 266265001388 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 266265001389 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 266265001390 dimer interface [polypeptide binding]; other site 266265001391 anticodon binding site; other site 266265001392 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 266265001393 homodimer interface [polypeptide binding]; other site 266265001394 motif 1; other site 266265001395 active site 266265001396 motif 2; other site 266265001397 GAD domain; Region: GAD; pfam02938 266265001398 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 266265001399 motif 3; other site 266265001400 dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438 266265001401 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 266265001402 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 266265001403 putative active site [active] 266265001404 catalytic site [active] 266265001405 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 266265001406 putative active site [active] 266265001407 catalytic site [active] 266265001408 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265001409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265001410 binding surface 266265001411 TPR repeat; Region: TPR_11; pfam13414 266265001412 TPR motif; other site 266265001413 TPR repeat; Region: TPR_11; pfam13414 266265001414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265001415 binding surface 266265001416 TPR motif; other site 266265001417 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 266265001418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265001419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265001420 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266265001421 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266265001422 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 266265001423 FAD binding site [chemical binding]; other site 266265001424 substrate binding site [chemical binding]; other site 266265001425 catalytic residues [active] 266265001426 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266265001427 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266265001428 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265001429 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265001430 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265001431 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265001432 substrate binding site [chemical binding]; other site 266265001433 oxyanion hole (OAH) forming residues; other site 266265001434 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 266265001435 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265001436 dimer interface [polypeptide binding]; other site 266265001437 active site 266265001438 enoyl-CoA hydratase; Provisional; Region: PRK06688 266265001439 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265001440 substrate binding site [chemical binding]; other site 266265001441 oxyanion hole (OAH) forming residues; other site 266265001442 trimer interface [polypeptide binding]; other site 266265001443 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 266265001444 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 266265001445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265001446 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266265001447 putative active site [active] 266265001448 heme pocket [chemical binding]; other site 266265001449 PAS domain; Region: PAS_9; pfam13426 266265001450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265001451 putative active site [active] 266265001452 heme pocket [chemical binding]; other site 266265001453 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265001454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265001455 metal binding site [ion binding]; metal-binding site 266265001456 active site 266265001457 I-site; other site 266265001458 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265001459 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265001460 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266265001461 C-terminal domain interface [polypeptide binding]; other site 266265001462 GSH binding site (G-site) [chemical binding]; other site 266265001463 dimer interface [polypeptide binding]; other site 266265001464 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266265001465 N-terminal domain interface [polypeptide binding]; other site 266265001466 putative substrate binding pocket (H-site) [chemical binding]; other site 266265001467 dimer interface [polypeptide binding]; other site 266265001468 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265001469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265001470 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265001471 dimerization interface [polypeptide binding]; other site 266265001472 substrate binding pocket [chemical binding]; other site 266265001473 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266265001474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266265001475 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 266265001476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265001477 Walker A/P-loop; other site 266265001478 ATP binding site [chemical binding]; other site 266265001479 Q-loop/lid; other site 266265001480 ABC transporter signature motif; other site 266265001481 Walker B; other site 266265001482 D-loop; other site 266265001483 H-loop/switch region; other site 266265001484 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 266265001485 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 266265001486 Substrate binding site; other site 266265001487 metal-binding site 266265001488 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 266265001489 Phosphotransferase enzyme family; Region: APH; pfam01636 266265001490 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 266265001491 Organic solvent tolerance protein; Region: OstA_C; pfam04453 266265001492 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 266265001493 SurA N-terminal domain; Region: SurA_N; pfam09312 266265001494 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266265001495 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266265001496 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 266265001497 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266265001498 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 266265001499 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 266265001500 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266265001501 EamA-like transporter family; Region: EamA; pfam00892 266265001502 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265001503 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265001504 trimer interface [polypeptide binding]; other site 266265001505 eyelet of channel; other site 266265001506 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265001507 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 266265001508 dimer interface [polypeptide binding]; other site 266265001509 active site 266265001510 metal binding site [ion binding]; metal-binding site 266265001511 glutathione binding site [chemical binding]; other site 266265001512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 266265001513 Protein of unknown function DUF45; Region: DUF45; pfam01863 266265001514 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266265001515 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266265001516 putative acyl-acceptor binding pocket; other site 266265001517 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 266265001518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265001519 active site 266265001520 motif I; other site 266265001521 motif II; other site 266265001522 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 266265001523 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266265001524 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 266265001525 dimer interface [polypeptide binding]; other site 266265001526 motif 1; other site 266265001527 active site 266265001528 motif 2; other site 266265001529 motif 3; other site 266265001530 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 266265001531 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266265001532 active site 266265001533 FMN binding site [chemical binding]; other site 266265001534 substrate binding site [chemical binding]; other site 266265001535 3Fe-4S cluster binding site [ion binding]; other site 266265001536 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 266265001537 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 266265001538 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 266265001539 nudix motif; other site 266265001540 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 266265001541 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 266265001542 ligand binding site [chemical binding]; other site 266265001543 homodimer interface [polypeptide binding]; other site 266265001544 NAD(P) binding site [chemical binding]; other site 266265001545 trimer interface B [polypeptide binding]; other site 266265001546 trimer interface A [polypeptide binding]; other site 266265001547 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 266265001548 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 266265001549 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266265001550 Predicted transcriptional regulator [Transcription]; Region: COG2378 266265001551 HTH domain; Region: HTH_11; pfam08279 266265001552 WYL domain; Region: WYL; pfam13280 266265001553 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 266265001554 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265001555 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 266265001556 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 266265001557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266265001558 Site-specific recombinase; Region: SpecificRecomb; pfam10136 266265001559 Protein of unknown function (DUF330); Region: DUF330; pfam03886 266265001560 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 266265001561 mce related protein; Region: MCE; pfam02470 266265001562 mce related protein; Region: MCE; pfam02470 266265001563 mce related protein; Region: MCE; pfam02470 266265001564 Paraquat-inducible protein A; Region: PqiA; pfam04403 266265001565 Paraquat-inducible protein A; Region: PqiA; pfam04403 266265001566 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266265001567 YceI-like domain; Region: YceI; smart00867 266265001568 Uncharacterized conserved protein [Function unknown]; Region: COG2353 266265001569 citrate-proton symporter; Provisional; Region: PRK15075 266265001570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001571 putative substrate translocation pore; other site 266265001572 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 266265001573 Protein export membrane protein; Region: SecD_SecF; pfam02355 266265001574 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 266265001575 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 266265001576 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 266265001577 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 266265001578 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 266265001579 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 266265001580 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 266265001581 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 266265001582 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 266265001583 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 266265001584 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 266265001585 generic binding surface II; other site 266265001586 ssDNA binding site; other site 266265001587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265001588 ATP binding site [chemical binding]; other site 266265001589 putative Mg++ binding site [ion binding]; other site 266265001590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265001591 nucleotide binding region [chemical binding]; other site 266265001592 ATP-binding site [chemical binding]; other site 266265001593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265001594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265001595 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 266265001596 dimerization interface [polypeptide binding]; other site 266265001597 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 266265001598 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 266265001599 tetramer interface [polypeptide binding]; other site 266265001600 heme binding pocket [chemical binding]; other site 266265001601 NADPH binding site [chemical binding]; other site 266265001602 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 266265001603 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 266265001604 dimerization interface [polypeptide binding]; other site 266265001605 DPS ferroxidase diiron center [ion binding]; other site 266265001606 ion pore; other site 266265001607 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 266265001608 UbiA prenyltransferase family; Region: UbiA; pfam01040 266265001609 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 266265001610 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266265001611 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 266265001612 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266265001613 catalytic residue [active] 266265001614 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 266265001615 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266265001616 Cysteine-rich domain; Region: CCG; pfam02754 266265001617 Cysteine-rich domain; Region: CCG; pfam02754 266265001618 FAD binding domain; Region: FAD_binding_4; pfam01565 266265001619 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 266265001620 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 266265001621 FAD binding domain; Region: FAD_binding_4; pfam01565 266265001622 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265001623 FAD binding domain; Region: FAD_binding_4; pfam01565 266265001624 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 266265001625 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 266265001626 non-specific DNA binding site [nucleotide binding]; other site 266265001627 salt bridge; other site 266265001628 sequence-specific DNA binding site [nucleotide binding]; other site 266265001629 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 266265001630 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 266265001631 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266265001632 protease TldD; Provisional; Region: tldD; PRK10735 266265001633 nitrilase; Region: PLN02798 266265001634 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 266265001635 putative active site [active] 266265001636 catalytic triad [active] 266265001637 dimer interface [polypeptide binding]; other site 266265001638 TIGR02099 family protein; Region: TIGR02099 266265001639 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266265001640 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 266265001641 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266265001642 metal binding triad; other site 266265001643 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266265001644 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266265001645 metal binding triad; other site 266265001646 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266265001647 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 266265001648 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266265001649 Walker A/P-loop; other site 266265001650 ATP binding site [chemical binding]; other site 266265001651 Q-loop/lid; other site 266265001652 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 266265001653 ABC transporter signature motif; other site 266265001654 Walker B; other site 266265001655 D-loop; other site 266265001656 H-loop/switch region; other site 266265001657 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 266265001658 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 266265001659 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 266265001660 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 266265001661 ferrochelatase; Reviewed; Region: hemH; PRK00035 266265001662 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 266265001663 C-terminal domain interface [polypeptide binding]; other site 266265001664 active site 266265001665 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 266265001666 active site 266265001667 N-terminal domain interface [polypeptide binding]; other site 266265001668 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266265001669 RNA binding surface [nucleotide binding]; other site 266265001670 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 266265001671 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 266265001672 dimer interface [polypeptide binding]; other site 266265001673 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 266265001674 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266265001675 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 266265001676 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266265001677 nucleotide binding site [chemical binding]; other site 266265001678 chaperone protein DnaJ; Provisional; Region: PRK10767 266265001679 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266265001680 HSP70 interaction site [polypeptide binding]; other site 266265001681 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 266265001682 Zn binding sites [ion binding]; other site 266265001683 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266265001684 dimer interface [polypeptide binding]; other site 266265001685 aminodeoxychorismate synthase; Provisional; Region: PRK07508 266265001686 chorismate binding enzyme; Region: Chorismate_bind; cl10555 266265001687 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 266265001688 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266265001689 substrate-cofactor binding pocket; other site 266265001690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265001691 catalytic residue [active] 266265001692 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 266265001693 oligomerization interface [polypeptide binding]; other site 266265001694 active site 266265001695 metal binding site [ion binding]; metal-binding site 266265001696 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 266265001697 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 266265001698 Substrate-binding site [chemical binding]; other site 266265001699 Substrate specificity [chemical binding]; other site 266265001700 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 266265001701 catalytic center binding site [active] 266265001702 ATP binding site [chemical binding]; other site 266265001703 poly(A) polymerase; Region: pcnB; TIGR01942 266265001704 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266265001705 active site 266265001706 NTP binding site [chemical binding]; other site 266265001707 metal binding triad [ion binding]; metal-binding site 266265001708 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266265001709 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 266265001710 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266265001711 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 266265001712 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 266265001713 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 266265001714 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266265001715 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266265001716 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266265001717 active site 266265001718 DNA binding site [nucleotide binding] 266265001719 Int/Topo IB signature motif; other site 266265001720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265001721 sequence-specific DNA binding site [nucleotide binding]; other site 266265001722 salt bridge; other site 266265001723 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 266265001724 Replicase family; Region: Replicase; pfam03090 266265001725 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 266265001726 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 266265001727 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 266265001728 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 266265001729 dimerization interface [polypeptide binding]; other site 266265001730 putative ATP binding site [chemical binding]; other site 266265001731 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 266265001732 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 266265001733 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 266265001734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265001735 ATP binding site [chemical binding]; other site 266265001736 Mg2+ binding site [ion binding]; other site 266265001737 G-X-G motif; other site 266265001738 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 266265001739 ATP binding site [chemical binding]; other site 266265001740 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 266265001741 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266265001742 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266265001743 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266265001744 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266265001745 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266265001746 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266265001747 Cl- selectivity filter; other site 266265001748 Cl- binding residues [ion binding]; other site 266265001749 pore gating glutamate residue; other site 266265001750 dimer interface [polypeptide binding]; other site 266265001751 FOG: CBS domain [General function prediction only]; Region: COG0517 266265001752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 266265001753 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265001754 MarR family; Region: MarR_2; pfam12802 266265001755 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 266265001756 HPP family; Region: HPP; pfam04982 266265001757 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266265001758 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 266265001759 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265001760 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265001761 ligand binding site [chemical binding]; other site 266265001762 flexible hinge region; other site 266265001763 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266265001764 putative switch regulator; other site 266265001765 non-specific DNA interactions [nucleotide binding]; other site 266265001766 DNA binding site [nucleotide binding] 266265001767 sequence specific DNA binding site [nucleotide binding]; other site 266265001768 putative cAMP binding site [chemical binding]; other site 266265001769 PAS domain S-box; Region: sensory_box; TIGR00229 266265001770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265001771 putative active site [active] 266265001772 heme pocket [chemical binding]; other site 266265001773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266265001774 Histidine kinase; Region: HisKA_3; pfam07730 266265001775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265001776 ATP binding site [chemical binding]; other site 266265001777 Mg2+ binding site [ion binding]; other site 266265001778 G-X-G motif; other site 266265001779 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 266265001780 Tetratricopeptide repeat; Region: TPR_6; pfam13174 266265001781 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266265001782 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265001783 ligand binding site [chemical binding]; other site 266265001784 translocation protein TolB; Provisional; Region: tolB; PRK02889 266265001785 TolB amino-terminal domain; Region: TolB_N; pfam04052 266265001786 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266265001787 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266265001788 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266265001789 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266265001790 TolA protein; Region: tolA_full; TIGR02794 266265001791 TolA protein; Region: tolA_full; TIGR02794 266265001792 TonB C terminal; Region: TonB_2; pfam13103 266265001793 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265001794 TolR protein; Region: tolR; TIGR02801 266265001795 TolQ protein; Region: tolQ; TIGR02796 266265001796 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266265001797 active site 266265001798 malonic semialdehyde reductase; Provisional; Region: PRK10538 266265001799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265001800 NAD(P) binding site [chemical binding]; other site 266265001801 active site 266265001802 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 266265001803 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266265001804 dimer interface [polypeptide binding]; other site 266265001805 active site 266265001806 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266265001807 folate binding site [chemical binding]; other site 266265001808 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 266265001809 ATP cone domain; Region: ATP-cone; pfam03477 266265001810 Type II transport protein GspH; Region: GspH; pfam12019 266265001811 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 266265001812 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 266265001813 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 266265001814 Predicted membrane protein [Function unknown]; Region: COG5393 266265001815 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 266265001816 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266265001817 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266265001818 dimer interface [polypeptide binding]; other site 266265001819 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266265001820 catalytic triad [active] 266265001821 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 266265001822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265001823 FAD binding site [chemical binding]; other site 266265001824 substrate binding pocket [chemical binding]; other site 266265001825 catalytic base [active] 266265001826 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265001827 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265001828 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 266265001829 benzoate transport; Region: 2A0115; TIGR00895 266265001830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001831 putative substrate translocation pore; other site 266265001832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001833 putative substrate translocation pore; other site 266265001834 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 266265001835 fumarylacetoacetase; Region: PLN02856 266265001836 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 266265001837 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265001838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001839 putative substrate translocation pore; other site 266265001840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265001841 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266265001842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001843 putative substrate translocation pore; other site 266265001844 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265001845 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265001846 substrate binding site [chemical binding]; other site 266265001847 oxyanion hole (OAH) forming residues; other site 266265001848 trimer interface [polypeptide binding]; other site 266265001849 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266265001850 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 266265001851 putative ligand binding site [chemical binding]; other site 266265001852 putative NAD binding site [chemical binding]; other site 266265001853 catalytic site [active] 266265001854 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 266265001855 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 266265001856 TrkA-C domain; Region: TrkA_C; pfam02080 266265001857 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 266265001858 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 266265001859 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 266265001860 TrkA-C domain; Region: TrkA_C; pfam02080 266265001861 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 266265001862 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 266265001863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265001864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265001865 homodimer interface [polypeptide binding]; other site 266265001866 catalytic residue [active] 266265001867 major facilitator superfamily transporter; Provisional; Region: PRK05122 266265001868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265001869 putative substrate translocation pore; other site 266265001870 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 266265001871 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265001872 catalytic loop [active] 266265001873 iron binding site [ion binding]; other site 266265001874 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265001875 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266265001876 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 266265001877 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265001878 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265001879 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266265001880 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265001881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265001882 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 266265001883 putative substrate binding pocket [chemical binding]; other site 266265001884 putative dimerization interface [polypeptide binding]; other site 266265001885 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266265001886 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266265001887 putative catalytic residue [active] 266265001888 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 266265001889 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266265001890 periplasmic protein; Provisional; Region: PRK10568 266265001891 hypothetical protein; Region: PHA01806 266265001892 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266265001893 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265001894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265001895 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265001896 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 266265001897 putative sugar binding sites [chemical binding]; other site 266265001898 Q-X-W motif; other site 266265001899 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 266265001900 active site 266265001901 GDP-Mannose binding site [chemical binding]; other site 266265001902 dimer interface [polypeptide binding]; other site 266265001903 modified nudix motif 266265001904 metal binding site [ion binding]; metal-binding site 266265001905 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265001906 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266265001907 conserved cys residue [active] 266265001908 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 266265001909 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266265001910 Substrate binding site; other site 266265001911 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 266265001912 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266265001913 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266265001914 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 266265001915 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266265001916 SLBB domain; Region: SLBB; pfam10531 266265001917 tyrosine kinase; Provisional; Region: PRK11519 266265001918 Chain length determinant protein; Region: Wzz; pfam02706 266265001919 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266265001920 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266265001921 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266265001922 NADP-binding site; other site 266265001923 homotetramer interface [polypeptide binding]; other site 266265001924 substrate binding site [chemical binding]; other site 266265001925 homodimer interface [polypeptide binding]; other site 266265001926 active site 266265001927 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 266265001928 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 266265001929 NADP binding site [chemical binding]; other site 266265001930 active site 266265001931 putative substrate binding site [chemical binding]; other site 266265001932 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265001933 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265001934 putative glycosyl transferase; Provisional; Region: PRK10307 266265001935 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 266265001936 putative acyl transferase; Provisional; Region: PRK10502 266265001937 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 266265001938 putative trimer interface [polypeptide binding]; other site 266265001939 putative active site [active] 266265001940 putative substrate binding site [chemical binding]; other site 266265001941 putative CoA binding site [chemical binding]; other site 266265001942 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266265001943 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265001944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265001945 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 266265001946 putative ADP-binding pocket [chemical binding]; other site 266265001947 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265001948 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 266265001949 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 266265001950 tyrosine kinase; Provisional; Region: PRK11519 266265001951 Chain length determinant protein; Region: Wzz; pfam02706 266265001952 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266265001953 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 266265001954 P loop; other site 266265001955 Nucleotide binding site [chemical binding]; other site 266265001956 DTAP/Switch II; other site 266265001957 Switch I; other site 266265001958 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265001959 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265001960 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266265001961 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265001962 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265001963 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 266265001964 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 266265001965 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 266265001966 putative molybdopterin cofactor binding site [chemical binding]; other site 266265001967 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 266265001968 putative molybdopterin cofactor binding site; other site 266265001969 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 266265001970 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266265001971 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266265001972 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 266265001973 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 266265001974 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265001975 FeS/SAM binding site; other site 266265001976 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 266265001977 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265001978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265001979 DNA-binding site [nucleotide binding]; DNA binding site 266265001980 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265001981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265001982 homodimer interface [polypeptide binding]; other site 266265001983 catalytic residue [active] 266265001984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265001985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265001986 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265001987 putative effector binding pocket; other site 266265001988 dimerization interface [polypeptide binding]; other site 266265001989 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 266265001990 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 266265001991 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266265001992 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 266265001993 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 266265001994 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266265001995 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266265001996 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 266265001997 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265001998 Ligand Binding Site [chemical binding]; other site 266265001999 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 266265002000 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 266265002001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265002002 catalytic residue [active] 266265002003 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 266265002004 PRC-barrel domain; Region: PRC; pfam05239 266265002005 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266265002006 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265002007 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265002008 ligand binding site [chemical binding]; other site 266265002009 flexible hinge region; other site 266265002010 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266265002011 non-specific DNA interactions [nucleotide binding]; other site 266265002012 DNA binding site [nucleotide binding] 266265002013 sequence specific DNA binding site [nucleotide binding]; other site 266265002014 putative cAMP binding site [chemical binding]; other site 266265002015 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 266265002016 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266265002017 oligomerisation interface [polypeptide binding]; other site 266265002018 mobile loop; other site 266265002019 roof hairpin; other site 266265002020 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266265002021 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266265002022 ring oligomerisation interface [polypeptide binding]; other site 266265002023 ATP/Mg binding site [chemical binding]; other site 266265002024 stacking interactions; other site 266265002025 hinge regions; other site 266265002026 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 266265002027 dimer interface [polypeptide binding]; other site 266265002028 substrate binding site [chemical binding]; other site 266265002029 ATP binding site [chemical binding]; other site 266265002030 Rubredoxin [Energy production and conversion]; Region: COG1773 266265002031 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266265002032 iron binding site [ion binding]; other site 266265002033 hypothetical protein; Validated; Region: PRK00228 266265002034 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 266265002035 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 266265002036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265002037 active site 266265002038 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 266265002039 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266265002040 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266265002041 dihydroorotase; Provisional; Region: PRK07627 266265002042 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 266265002043 active site 266265002044 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266265002045 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266265002046 putative acyl-acceptor binding pocket; other site 266265002047 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 266265002048 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 266265002049 active site 266265002050 metal binding site [ion binding]; metal-binding site 266265002051 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266265002052 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 266265002053 NADP-binding site; other site 266265002054 homotetramer interface [polypeptide binding]; other site 266265002055 substrate binding site [chemical binding]; other site 266265002056 homodimer interface [polypeptide binding]; other site 266265002057 active site 266265002058 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 266265002059 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 266265002060 NAD binding site [chemical binding]; other site 266265002061 substrate binding site [chemical binding]; other site 266265002062 homodimer interface [polypeptide binding]; other site 266265002063 active site 266265002064 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 266265002065 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 266265002066 NADP binding site [chemical binding]; other site 266265002067 active site 266265002068 putative substrate binding site [chemical binding]; other site 266265002069 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 266265002070 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 266265002071 substrate binding site; other site 266265002072 tetramer interface; other site 266265002073 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 266265002074 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 266265002075 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266265002076 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 266265002077 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 266265002078 Walker A/P-loop; other site 266265002079 ATP binding site [chemical binding]; other site 266265002080 Q-loop/lid; other site 266265002081 ABC transporter signature motif; other site 266265002082 Walker B; other site 266265002083 D-loop; other site 266265002084 H-loop/switch region; other site 266265002085 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 266265002086 putative carbohydrate binding site [chemical binding]; other site 266265002087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265002088 S-adenosylmethionine binding site [chemical binding]; other site 266265002089 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266265002090 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266265002091 Probable Catalytic site; other site 266265002092 metal-binding site 266265002093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265002094 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265002095 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265002096 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265002097 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 266265002098 Probable Catalytic site; other site 266265002099 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265002100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265002101 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265002102 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265002103 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265002104 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265002105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265002106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266265002107 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 266265002108 Predicted membrane protein [Function unknown]; Region: COG2246 266265002109 GtrA-like protein; Region: GtrA; pfam04138 266265002110 hypothetical protein; Provisional; Region: PRK07233 266265002111 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265002112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265002113 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 266265002114 NAD(P) binding site [chemical binding]; other site 266265002115 active site 266265002116 short chain dehydrogenase; Provisional; Region: PRK07102 266265002117 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266265002118 NAD(P) binding site [chemical binding]; other site 266265002119 active site 266265002120 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265002121 FAD binding domain; Region: FAD_binding_4; pfam01565 266265002122 Phosphoenolpyruvate carboxylase; Region: PEPcase_2; cl17501 266265002123 hypothetical protein; Validated; Region: PRK08238 266265002124 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 266265002125 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 266265002126 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266265002127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266265002128 active site 266265002129 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266265002130 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265002131 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 266265002132 putative NAD(P) binding site [chemical binding]; other site 266265002133 active site 266265002134 putative substrate binding site [chemical binding]; other site 266265002135 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 266265002136 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 266265002137 Mg++ binding site [ion binding]; other site 266265002138 putative catalytic motif [active] 266265002139 putative substrate binding site [chemical binding]; other site 266265002140 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 266265002141 CoA binding domain; Region: CoA_binding; cl17356 266265002142 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 266265002143 NAD(P) binding site [chemical binding]; other site 266265002144 homodimer interface [polypeptide binding]; other site 266265002145 substrate binding site [chemical binding]; other site 266265002146 active site 266265002147 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265002148 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265002149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265002150 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265002151 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265002152 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265002153 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265002154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265002155 Transposase; Region: HTH_Tnp_1; pfam01527 266265002156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265002157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265002158 S-adenosylmethionine binding site [chemical binding]; other site 266265002159 Transposase; Region: HTH_Tnp_1; pfam01527 266265002160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265002161 putative transposase OrfB; Reviewed; Region: PHA02517 266265002162 HTH-like domain; Region: HTH_21; pfam13276 266265002163 Integrase core domain; Region: rve; pfam00665 266265002164 Integrase core domain; Region: rve_3; pfam13683 266265002165 HTH-like domain; Region: HTH_21; pfam13276 266265002166 Integrase core domain; Region: rve; pfam00665 266265002167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266265002168 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265002169 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265002170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265002171 Transposase; Region: HTH_Tnp_1; cl17663 266265002172 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265002173 Integrase core domain; Region: rve; pfam00665 266265002174 transposase; Validated; Region: PRK08181 266265002175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265002176 Walker A motif; other site 266265002177 ATP binding site [chemical binding]; other site 266265002178 Walker B motif; other site 266265002179 arginine finger; other site 266265002180 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 266265002181 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266265002182 active site 266265002183 catalytic residues [active] 266265002184 DNA binding site [nucleotide binding] 266265002185 Int/Topo IB signature motif; other site 266265002186 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 266265002187 Nuclease-related domain; Region: NERD; pfam08378 266265002188 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265002189 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266265002190 DNA binding residues [nucleotide binding] 266265002191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266265002192 Integrase core domain; Region: rve; pfam00665 266265002193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266265002194 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266265002195 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 266265002196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265002197 Walker A motif; other site 266265002198 ATP binding site [chemical binding]; other site 266265002199 Walker B motif; other site 266265002200 arginine finger; other site 266265002201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265002202 Transposase; Region: HTH_Tnp_1; pfam01527 266265002203 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265002204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265002205 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265002206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265002207 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265002208 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265002209 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265002210 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 266265002211 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 266265002212 active site 266265002213 homodimer interface [polypeptide binding]; other site 266265002214 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 266265002215 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 266265002216 Mg++ binding site [ion binding]; other site 266265002217 putative catalytic motif [active] 266265002218 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 266265002219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265002220 dimerization interface [polypeptide binding]; other site 266265002221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265002222 dimer interface [polypeptide binding]; other site 266265002223 putative CheW interface [polypeptide binding]; other site 266265002224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265002225 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265002226 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 266265002227 ligand binding site [chemical binding]; other site 266265002228 flexible hinge region; other site 266265002229 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266265002230 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 266265002231 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 266265002232 NAD binding site [chemical binding]; other site 266265002233 substrate binding site [chemical binding]; other site 266265002234 homodimer interface [polypeptide binding]; other site 266265002235 active site 266265002236 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 266265002237 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 266265002238 substrate binding site; other site 266265002239 tetramer interface; other site 266265002240 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266265002241 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266265002242 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266265002243 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266265002244 active site 266265002245 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 266265002246 trimer interface [polypeptide binding]; other site 266265002247 active site 266265002248 substrate binding site [chemical binding]; other site 266265002249 CoA binding site [chemical binding]; other site 266265002250 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265002251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265002252 NAD(P) binding site [chemical binding]; other site 266265002253 active site 266265002254 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266265002255 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266265002256 Probable Catalytic site; other site 266265002257 metal-binding site 266265002258 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 266265002259 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266265002260 inhibitor-cofactor binding pocket; inhibition site 266265002261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265002262 catalytic residue [active] 266265002263 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266265002264 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266265002265 putative active site [active] 266265002266 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 266265002267 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 266265002268 putative ribose interaction site [chemical binding]; other site 266265002269 putative ADP binding site [chemical binding]; other site 266265002270 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 266265002271 putative active cleft [active] 266265002272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265002273 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 266265002274 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266265002275 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265002276 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265002277 Walker A/P-loop; other site 266265002278 ATP binding site [chemical binding]; other site 266265002279 Q-loop/lid; other site 266265002280 ABC transporter signature motif; other site 266265002281 Walker B; other site 266265002282 D-loop; other site 266265002283 H-loop/switch region; other site 266265002284 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265002285 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265002286 TM-ABC transporter signature motif; other site 266265002287 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265002288 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265002289 Walker A/P-loop; other site 266265002290 ATP binding site [chemical binding]; other site 266265002291 Q-loop/lid; other site 266265002292 ABC transporter signature motif; other site 266265002293 Walker B; other site 266265002294 D-loop; other site 266265002295 H-loop/switch region; other site 266265002296 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265002297 TM-ABC transporter signature motif; other site 266265002298 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265002299 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 266265002300 putative ligand binding site [chemical binding]; other site 266265002301 UDP-glucose 4-epimerase; Region: PLN02240 266265002302 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 266265002303 NAD binding site [chemical binding]; other site 266265002304 homodimer interface [polypeptide binding]; other site 266265002305 active site 266265002306 substrate binding site [chemical binding]; other site 266265002307 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 266265002308 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265002309 putative ADP-binding pocket [chemical binding]; other site 266265002310 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266265002311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266265002312 active site 266265002313 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266265002314 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266265002315 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 266265002316 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 266265002317 active site 266265002318 substrate binding site [chemical binding]; other site 266265002319 metal binding site [ion binding]; metal-binding site 266265002320 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266265002321 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266265002322 putative active site [active] 266265002323 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 266265002324 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 266265002325 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 266265002326 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265002327 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265002328 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 266265002329 UreF; Region: UreF; pfam01730 266265002330 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 266265002331 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 266265002332 dimer interface [polypeptide binding]; other site 266265002333 catalytic residues [active] 266265002334 urease subunit alpha; Reviewed; Region: ureC; PRK13207 266265002335 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 266265002336 subunit interactions [polypeptide binding]; other site 266265002337 active site 266265002338 flap region; other site 266265002339 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 266265002340 gamma-beta subunit interface [polypeptide binding]; other site 266265002341 alpha-beta subunit interface [polypeptide binding]; other site 266265002342 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 266265002343 alpha-gamma subunit interface [polypeptide binding]; other site 266265002344 beta-gamma subunit interface [polypeptide binding]; other site 266265002345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265002346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265002347 substrate binding pocket [chemical binding]; other site 266265002348 membrane-bound complex binding site; other site 266265002349 hinge residues; other site 266265002350 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266265002351 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 266265002352 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 266265002353 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265002354 Walker A/P-loop; other site 266265002355 ATP binding site [chemical binding]; other site 266265002356 Q-loop/lid; other site 266265002357 ABC transporter signature motif; other site 266265002358 Walker B; other site 266265002359 D-loop; other site 266265002360 H-loop/switch region; other site 266265002361 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 266265002362 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265002363 Walker A/P-loop; other site 266265002364 ATP binding site [chemical binding]; other site 266265002365 Q-loop/lid; other site 266265002366 ABC transporter signature motif; other site 266265002367 Walker B; other site 266265002368 D-loop; other site 266265002369 H-loop/switch region; other site 266265002370 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265002371 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265002372 TM-ABC transporter signature motif; other site 266265002373 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265002374 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265002375 TM-ABC transporter signature motif; other site 266265002376 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265002377 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 266265002378 putative ligand binding site [chemical binding]; other site 266265002379 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 266265002380 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 266265002381 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 266265002382 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 266265002383 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265002384 active site residue [active] 266265002385 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266265002386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265002387 S-adenosylmethionine binding site [chemical binding]; other site 266265002388 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265002389 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265002390 DNA binding site [nucleotide binding] 266265002391 domain linker motif; other site 266265002392 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 266265002393 dimerization interface [polypeptide binding]; other site 266265002394 ligand binding site [chemical binding]; other site 266265002395 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265002396 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265002397 Walker A/P-loop; other site 266265002398 ATP binding site [chemical binding]; other site 266265002399 Q-loop/lid; other site 266265002400 ABC transporter signature motif; other site 266265002401 Walker B; other site 266265002402 D-loop; other site 266265002403 H-loop/switch region; other site 266265002404 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265002405 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265002406 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265002407 TM-ABC transporter signature motif; other site 266265002408 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266265002409 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 266265002410 putative ligand binding site [chemical binding]; other site 266265002411 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266265002412 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 266265002413 Metal-binding active site; metal-binding site 266265002414 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 266265002415 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266265002416 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266265002417 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266265002418 TIGR02646 family protein; Region: TIGR02646 266265002419 AAA domain; Region: AAA_21; pfam13304 266265002420 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265002421 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 266265002422 putative ligand binding site [chemical binding]; other site 266265002423 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 266265002424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265002425 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 266265002426 substrate binding site [chemical binding]; other site 266265002427 dimerization interface [polypeptide binding]; other site 266265002428 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 266265002429 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266265002430 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266265002431 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 266265002432 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 266265002433 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266265002434 Active Sites [active] 266265002435 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 266265002436 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266265002437 Active Sites [active] 266265002438 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 266265002439 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 266265002440 CysD dimerization site [polypeptide binding]; other site 266265002441 G1 box; other site 266265002442 putative GEF interaction site [polypeptide binding]; other site 266265002443 GTP/Mg2+ binding site [chemical binding]; other site 266265002444 Switch I region; other site 266265002445 G2 box; other site 266265002446 G3 box; other site 266265002447 Switch II region; other site 266265002448 G4 box; other site 266265002449 G5 box; other site 266265002450 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 266265002451 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 266265002452 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266265002453 active site 266265002454 SAM binding site [chemical binding]; other site 266265002455 homodimer interface [polypeptide binding]; other site 266265002456 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 266265002457 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 266265002458 Int/Topo IB signature motif; other site 266265002459 Helix-turn-helix domain; Region: HTH_17; cl17695 266265002460 AAA domain; Region: AAA_25; pfam13481 266265002461 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265002462 ATP binding site [chemical binding]; other site 266265002463 Walker B motif; other site 266265002464 MAEBL; Provisional; Region: PTZ00121 266265002465 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 266265002466 tandem repeat interface [polypeptide binding]; other site 266265002467 oligomer interface [polypeptide binding]; other site 266265002468 active site residues [active] 266265002469 haemagglutination activity domain; Region: Haemagg_act; pfam05860 266265002470 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 266265002471 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266265002472 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266265002473 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 266265002474 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 266265002475 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 266265002476 Winged helix-turn helix; Region: HTH_29; pfam13551 266265002477 Helix-turn-helix domain; Region: HTH_28; pfam13518 266265002478 Homeodomain-like domain; Region: HTH_32; pfam13565 266265002479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266265002480 Integrase core domain; Region: rve; pfam00665 266265002481 Integrase core domain; Region: rve_3; pfam13683 266265002482 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 266265002483 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 266265002484 putative active site [active] 266265002485 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 266265002486 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266265002487 Predicted permeases [General function prediction only]; Region: COG0795 266265002488 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 266265002489 multifunctional aminopeptidase A; Provisional; Region: PRK00913 266265002490 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 266265002491 interface (dimer of trimers) [polypeptide binding]; other site 266265002492 Substrate-binding/catalytic site; other site 266265002493 Zn-binding sites [ion binding]; other site 266265002494 DNA polymerase III subunit chi; Validated; Region: PRK05728 266265002495 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 266265002496 Cytochrome c; Region: Cytochrom_C; cl11414 266265002497 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 266265002498 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266265002499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265002500 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 266265002501 putative dimerization interface [polypeptide binding]; other site 266265002502 putative substrate binding pocket [chemical binding]; other site 266265002503 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 266265002504 Protein of unknown function (DUF541); Region: SIMPL; cl01077 266265002505 EVE domain; Region: EVE; cl00728 266265002506 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 266265002507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265002508 non-specific DNA binding site [nucleotide binding]; other site 266265002509 sequence-specific DNA binding site [nucleotide binding]; other site 266265002510 salt bridge; other site 266265002511 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 266265002512 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 266265002513 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265002514 FCD domain; Region: FCD; pfam07729 266265002515 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265002516 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265002517 EthD domain; Region: EthD; cl17553 266265002518 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 266265002519 NAD(P) binding site [chemical binding]; other site 266265002520 active site 266265002521 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265002522 classical (c) SDRs; Region: SDR_c; cd05233 266265002523 NAD(P) binding site [chemical binding]; other site 266265002524 active site 266265002525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002526 putative substrate translocation pore; other site 266265002527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265002528 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265002529 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265002530 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266265002531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002532 putative substrate translocation pore; other site 266265002533 NIPSNAP; Region: NIPSNAP; pfam07978 266265002534 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265002535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265002536 NAD(P) binding site [chemical binding]; other site 266265002537 active site 266265002538 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 266265002539 putative succinate dehydrogenase; Reviewed; Region: PRK12842 266265002540 Predicted oxidoreductase [General function prediction only]; Region: COG3573 266265002541 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266265002542 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265002543 substrate binding pocket [chemical binding]; other site 266265002544 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265002545 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265002546 trimer interface [polypeptide binding]; other site 266265002547 eyelet of channel; other site 266265002548 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265002549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265002550 NAD(P) binding site [chemical binding]; other site 266265002551 active site 266265002552 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266265002553 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265002554 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 266265002555 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265002556 active site 266265002557 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 266265002558 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266265002559 DUF35 OB-fold domain; Region: DUF35; pfam01796 266265002560 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265002561 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265002562 NAD(P) binding site [chemical binding]; other site 266265002563 catalytic residues [active] 266265002564 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266265002565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002566 putative substrate translocation pore; other site 266265002567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002568 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265002569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265002570 DNA-binding site [nucleotide binding]; DNA binding site 266265002571 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266265002572 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266265002573 choline dehydrogenase; Validated; Region: PRK02106 266265002574 lycopene cyclase; Region: lycopene_cycl; TIGR01789 266265002575 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265002576 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265002577 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265002578 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266265002579 Cytochrome P450; Region: p450; cl12078 266265002580 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266265002581 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265002582 catalytic loop [active] 266265002583 iron binding site [ion binding]; other site 266265002584 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266265002585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265002586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265002587 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 266265002588 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 266265002589 active site 266265002590 putative substrate binding pocket [chemical binding]; other site 266265002591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265002592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265002593 short chain dehydrogenase; Provisional; Region: PRK12828 266265002594 NAD(P) binding site [chemical binding]; other site 266265002595 active site 266265002596 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266265002597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266265002598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265002599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265002600 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265002601 putative effector binding pocket; other site 266265002602 dimerization interface [polypeptide binding]; other site 266265002603 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265002604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002605 putative substrate translocation pore; other site 266265002606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002607 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 266265002608 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265002609 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265002610 SPRY domain; Region: SPRY; cl02614 266265002611 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265002612 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265002613 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 266265002614 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265002615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002616 putative substrate translocation pore; other site 266265002617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265002619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265002620 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266265002621 dimerization interface [polypeptide binding]; other site 266265002622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002623 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265002624 putative substrate translocation pore; other site 266265002625 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266265002626 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266265002627 tetrameric interface [polypeptide binding]; other site 266265002628 NAD binding site [chemical binding]; other site 266265002629 catalytic residues [active] 266265002630 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265002631 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 266265002632 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265002633 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265002634 active site 266265002635 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266265002636 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 266265002637 active site 266265002638 acyl-activating enzyme (AAE) consensus motif; other site 266265002639 putative CoA binding site [chemical binding]; other site 266265002640 AMP binding site [chemical binding]; other site 266265002641 enoyl-CoA hydratase; Provisional; Region: PRK09076 266265002642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265002643 substrate binding site [chemical binding]; other site 266265002644 oxyanion hole (OAH) forming residues; other site 266265002645 trimer interface [polypeptide binding]; other site 266265002646 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 266265002647 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265002648 substrate binding site [chemical binding]; other site 266265002649 oxyanion hole (OAH) forming residues; other site 266265002650 trimer interface [polypeptide binding]; other site 266265002651 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 266265002652 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266265002653 Ligand binding site [chemical binding]; other site 266265002654 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266265002655 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266265002656 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266265002657 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266265002658 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266265002659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265002660 DNA binding residues [nucleotide binding] 266265002661 dimerization interface [polypeptide binding]; other site 266265002662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265002663 Transposase; Region: HTH_Tnp_1; pfam01527 266265002664 putative transposase OrfB; Reviewed; Region: PHA02517 266265002665 HTH-like domain; Region: HTH_21; pfam13276 266265002666 Integrase core domain; Region: rve; pfam00665 266265002667 Integrase core domain; Region: rve_3; pfam13683 266265002668 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266265002669 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265002670 Walker A motif; other site 266265002671 ATP binding site [chemical binding]; other site 266265002672 Walker B motif; other site 266265002673 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265002674 classical (c) SDRs; Region: SDR_c; cd05233 266265002675 NAD(P) binding site [chemical binding]; other site 266265002676 active site 266265002677 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265002678 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265002679 NAD(P) binding site [chemical binding]; other site 266265002680 catalytic residues [active] 266265002681 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 266265002682 Di-iron ligands [ion binding]; other site 266265002683 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266265002684 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265002685 catalytic loop [active] 266265002686 iron binding site [ion binding]; other site 266265002687 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213 266265002688 FAD binding pocket [chemical binding]; other site 266265002689 FAD binding motif [chemical binding]; other site 266265002690 phosphate binding motif [ion binding]; other site 266265002691 beta-alpha-beta structure motif; other site 266265002692 NAD binding pocket [chemical binding]; other site 266265002693 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 266265002694 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266265002695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265002696 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265002697 [2Fe-2S] cluster binding site [ion binding]; other site 266265002698 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 266265002699 putative alpha subunit interface [polypeptide binding]; other site 266265002700 putative active site [active] 266265002701 putative substrate binding site [chemical binding]; other site 266265002702 Fe binding site [ion binding]; other site 266265002703 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265002704 inter-subunit interface; other site 266265002705 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 266265002706 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266265002707 active site 266265002708 metal binding site [ion binding]; metal-binding site 266265002709 C-terminal domain of 2,3-dihydroxy-p-cumate-3,4-dioxygenase (PpCmtC); Region: PpCmtC_C; cd07258 266265002710 putative active site [active] 266265002711 putative metal binding site [ion binding]; other site 266265002712 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265002713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265002714 NAD(P) binding site [chemical binding]; other site 266265002715 active site 266265002716 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266265002717 [2Fe-2S] cluster binding site [ion binding]; other site 266265002718 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 266265002719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265002720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265002721 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265002722 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265002723 acetaldehyde dehydrogenase; Validated; Region: PRK08300 266265002724 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266265002725 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 266265002726 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 266265002727 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 266265002728 active site 266265002729 catalytic residues [active] 266265002730 metal binding site [ion binding]; metal-binding site 266265002731 DmpG-like communication domain; Region: DmpG_comm; pfam07836 266265002732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265002733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265002734 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266265002735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265002736 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265002737 dimerization interface [polypeptide binding]; other site 266265002738 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265002739 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265002740 iron-sulfur cluster [ion binding]; other site 266265002741 [2Fe-2S] cluster binding site [ion binding]; other site 266265002742 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 266265002743 alpha subunit interface [polypeptide binding]; other site 266265002744 active site 266265002745 substrate binding site [chemical binding]; other site 266265002746 Fe binding site [ion binding]; other site 266265002747 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266265002748 DUF35 OB-fold domain; Region: DUF35; pfam01796 266265002749 lipid-transfer protein; Provisional; Region: PRK07855 266265002750 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265002751 active site 266265002752 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265002753 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265002754 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266265002755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002756 putative substrate translocation pore; other site 266265002757 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 266265002758 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265002759 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266265002760 hydrophobic ligand binding site; other site 266265002761 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265002762 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266265002763 FMN-binding pocket [chemical binding]; other site 266265002764 flavin binding motif; other site 266265002765 phosphate binding motif [ion binding]; other site 266265002766 beta-alpha-beta structure motif; other site 266265002767 NAD binding pocket [chemical binding]; other site 266265002768 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265002769 catalytic loop [active] 266265002770 iron binding site [ion binding]; other site 266265002771 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265002772 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265002773 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265002774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265002775 DNA-binding site [nucleotide binding]; DNA binding site 266265002776 FCD domain; Region: FCD; pfam07729 266265002777 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265002778 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265002779 eyelet of channel; other site 266265002780 trimer interface [polypeptide binding]; other site 266265002781 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 266265002782 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265002783 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266265002784 hydrophobic ligand binding site; other site 266265002785 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265002786 classical (c) SDRs; Region: SDR_c; cd05233 266265002787 NAD(P) binding site [chemical binding]; other site 266265002788 active site 266265002789 benzoate transport; Region: 2A0115; TIGR00895 266265002790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002791 putative substrate translocation pore; other site 266265002792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002793 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 266265002794 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265002795 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266265002796 hydrophobic ligand binding site; other site 266265002797 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265002798 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265002799 trimer interface [polypeptide binding]; other site 266265002800 eyelet of channel; other site 266265002801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265002802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265002803 putative substrate translocation pore; other site 266265002804 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 266265002805 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265002806 NAD binding site [chemical binding]; other site 266265002807 catalytic residues [active] 266265002808 choline dehydrogenase; Validated; Region: PRK02106 266265002809 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265002810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265002811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265002812 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 266265002813 Hemerythrin; Region: Hemerythrin; cd12107 266265002814 Fe binding site [ion binding]; other site 266265002815 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265002816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266265002817 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265002818 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266265002819 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265002820 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266265002821 Homeodomain-like domain; Region: HTH_23; pfam13384 266265002822 Winged helix-turn helix; Region: HTH_29; pfam13551 266265002823 Homeodomain-like domain; Region: HTH_32; pfam13565 266265002824 DDE superfamily endonuclease; Region: DDE_3; pfam13358 266265002825 EVE domain; Region: EVE; cl00728 266265002826 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266265002827 active site 266265002828 catalytic residues [active] 266265002829 Int/Topo IB signature motif; other site 266265002830 DNA binding site [nucleotide binding] 266265002831 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265002832 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266265002833 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266265002834 EVE domain; Region: EVE; cl00728 266265002835 Cell division protein ZapA; Region: ZapA; pfam05164 266265002836 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 266265002837 primary dimer interface [polypeptide binding]; other site 266265002838 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 266265002839 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265002840 N-terminal plug; other site 266265002841 ligand-binding site [chemical binding]; other site 266265002842 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266265002843 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266265002844 ABC-ATPase subunit interface; other site 266265002845 dimer interface [polypeptide binding]; other site 266265002846 putative PBP binding regions; other site 266265002847 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266265002848 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266265002849 Walker A/P-loop; other site 266265002850 ATP binding site [chemical binding]; other site 266265002851 Q-loop/lid; other site 266265002852 ABC transporter signature motif; other site 266265002853 Walker B; other site 266265002854 D-loop; other site 266265002855 H-loop/switch region; other site 266265002856 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 266265002857 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 266265002858 putative dimer interface [polypeptide binding]; other site 266265002859 active site pocket [active] 266265002860 putative cataytic base [active] 266265002861 cobalamin synthase; Reviewed; Region: cobS; PRK00235 266265002862 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266265002863 catalytic core [active] 266265002864 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 266265002865 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 266265002866 cobalamin binding residues [chemical binding]; other site 266265002867 putative BtuC binding residues; other site 266265002868 dimer interface [polypeptide binding]; other site 266265002869 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 266265002870 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265002871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265002872 homodimer interface [polypeptide binding]; other site 266265002873 catalytic residue [active] 266265002874 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 266265002875 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 266265002876 homotrimer interface [polypeptide binding]; other site 266265002877 Walker A motif; other site 266265002878 GTP binding site [chemical binding]; other site 266265002879 Walker B motif; other site 266265002880 cobyric acid synthase; Provisional; Region: PRK00784 266265002881 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 266265002882 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 266265002883 catalytic triad [active] 266265002884 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266265002885 CoenzymeA binding site [chemical binding]; other site 266265002886 subunit interaction site [polypeptide binding]; other site 266265002887 PHB binding site; other site 266265002888 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266265002889 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265002890 P-loop; other site 266265002891 Magnesium ion binding site [ion binding]; other site 266265002892 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 266265002893 tetramerization interface [polypeptide binding]; other site 266265002894 active site 266265002895 pantoate--beta-alanine ligase; Region: panC; TIGR00018 266265002896 Pantoate-beta-alanine ligase; Region: PanC; cd00560 266265002897 active site 266265002898 ATP-binding site [chemical binding]; other site 266265002899 pantoate-binding site; other site 266265002900 HXXH motif; other site 266265002901 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 266265002902 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 266265002903 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 266265002904 Surface antigen; Region: Bac_surface_Ag; pfam01103 266265002905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 266265002906 Family of unknown function (DUF490); Region: DUF490; pfam04357 266265002907 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 266265002908 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 266265002909 active site 266265002910 HIGH motif; other site 266265002911 KMSKS motif; other site 266265002912 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 266265002913 tRNA binding surface [nucleotide binding]; other site 266265002914 anticodon binding site; other site 266265002915 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 266265002916 dimer interface [polypeptide binding]; other site 266265002917 putative tRNA-binding site [nucleotide binding]; other site 266265002918 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266265002919 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265002920 ligand binding site [chemical binding]; other site 266265002921 Domain of unknown function DUF59; Region: DUF59; pfam01883 266265002922 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 266265002923 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 266265002924 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265002925 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265002926 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 266265002927 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 266265002928 E-class dimer interface [polypeptide binding]; other site 266265002929 P-class dimer interface [polypeptide binding]; other site 266265002930 active site 266265002931 Cu2+ binding site [ion binding]; other site 266265002932 Zn2+ binding site [ion binding]; other site 266265002933 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266265002934 trimer interface [polypeptide binding]; other site 266265002935 active site 266265002936 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 266265002937 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 266265002938 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266265002939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265002940 catalytic residue [active] 266265002941 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 266265002942 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 266265002943 Predicted membrane protein [Function unknown]; Region: COG3781 266265002944 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 266265002945 EamA-like transporter family; Region: EamA; cl17759 266265002946 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265002947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265002948 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265002949 dimerization interface [polypeptide binding]; other site 266265002950 substrate binding pocket [chemical binding]; other site 266265002951 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265002953 conserved gate region; other site 266265002954 dimer interface [polypeptide binding]; other site 266265002955 putative PBP binding loops; other site 266265002956 ABC-ATPase subunit interface; other site 266265002957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265002958 dimer interface [polypeptide binding]; other site 266265002959 conserved gate region; other site 266265002960 putative PBP binding loops; other site 266265002961 ABC-ATPase subunit interface; other site 266265002962 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265002963 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265002964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265002965 Walker A/P-loop; other site 266265002966 ATP binding site [chemical binding]; other site 266265002967 Q-loop/lid; other site 266265002968 ABC transporter signature motif; other site 266265002969 Walker B; other site 266265002970 D-loop; other site 266265002971 H-loop/switch region; other site 266265002972 TOBE domain; Region: TOBE_2; pfam08402 266265002973 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265002974 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265002975 [2Fe-2S] cluster binding site [ion binding]; other site 266265002976 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 266265002977 putative alpha subunit interface [polypeptide binding]; other site 266265002978 putative active site [active] 266265002979 putative substrate binding site [chemical binding]; other site 266265002980 Fe binding site [ion binding]; other site 266265002981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265002982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265002983 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 266265002984 putative substrate binding pocket [chemical binding]; other site 266265002985 dimerization interface [polypeptide binding]; other site 266265002986 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 266265002987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265002988 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266265002989 homotrimer interaction site [polypeptide binding]; other site 266265002990 putative active site [active] 266265002991 Uncharacterized conserved protein [Function unknown]; Region: COG3342 266265002992 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 266265002993 acetylornithine deacetylase; Provisional; Region: PRK07522 266265002994 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 266265002995 metal binding site [ion binding]; metal-binding site 266265002996 putative dimer interface [polypeptide binding]; other site 266265002997 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265002998 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265002999 trimer interface [polypeptide binding]; other site 266265003000 eyelet of channel; other site 266265003001 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266265003002 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 266265003003 putative heme binding pocket [chemical binding]; other site 266265003004 sensor protein QseC; Provisional; Region: PRK10337 266265003005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265003006 dimer interface [polypeptide binding]; other site 266265003007 phosphorylation site [posttranslational modification] 266265003008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265003009 Mg2+ binding site [ion binding]; other site 266265003010 G-X-G motif; other site 266265003011 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 266265003012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265003013 active site 266265003014 phosphorylation site [posttranslational modification] 266265003015 intermolecular recognition site; other site 266265003016 dimerization interface [polypeptide binding]; other site 266265003017 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265003018 DNA binding site [nucleotide binding] 266265003019 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 266265003020 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266265003021 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266265003022 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 266265003023 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 266265003024 glucokinase; Provisional; Region: glk; PRK00292 266265003025 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265003026 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266265003027 putative active site [active] 266265003028 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 266265003029 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 266265003030 putative active site [active] 266265003031 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 266265003032 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266265003033 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266265003034 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266265003035 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266265003036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266265003037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265003038 putative PBP binding loops; other site 266265003039 ABC-ATPase subunit interface; other site 266265003040 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266265003041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265003042 dimer interface [polypeptide binding]; other site 266265003043 conserved gate region; other site 266265003044 putative PBP binding loops; other site 266265003045 ABC-ATPase subunit interface; other site 266265003046 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266265003047 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266265003048 Walker A/P-loop; other site 266265003049 ATP binding site [chemical binding]; other site 266265003050 Q-loop/lid; other site 266265003051 ABC transporter signature motif; other site 266265003052 Walker B; other site 266265003053 D-loop; other site 266265003054 H-loop/switch region; other site 266265003055 transcriptional regulator; Provisional; Region: PRK10632 266265003056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265003057 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266265003058 putative effector binding pocket; other site 266265003059 putative dimerization interface [polypeptide binding]; other site 266265003060 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265003061 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266265003062 C-terminal domain interface [polypeptide binding]; other site 266265003063 GSH binding site (G-site) [chemical binding]; other site 266265003064 dimer interface [polypeptide binding]; other site 266265003065 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266265003066 N-terminal domain interface [polypeptide binding]; other site 266265003067 Predicted membrane protein [Function unknown]; Region: COG2860 266265003068 UPF0126 domain; Region: UPF0126; pfam03458 266265003069 UPF0126 domain; Region: UPF0126; pfam03458 266265003070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 266265003071 Smr domain; Region: Smr; pfam01713 266265003072 thioredoxin reductase; Provisional; Region: PRK10262 266265003073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265003074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265003075 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 266265003076 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266265003077 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266265003078 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 266265003079 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 266265003080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265003081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265003082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265003083 dimerization interface [polypeptide binding]; other site 266265003084 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 266265003085 agmatinase; Region: agmatinase; TIGR01230 266265003086 oligomer interface [polypeptide binding]; other site 266265003087 putative active site [active] 266265003088 Mn binding site [ion binding]; other site 266265003089 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266265003090 recombination factor protein RarA; Reviewed; Region: PRK13342 266265003091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265003092 Walker A motif; other site 266265003093 ATP binding site [chemical binding]; other site 266265003094 Walker B motif; other site 266265003095 arginine finger; other site 266265003096 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 266265003097 seryl-tRNA synthetase; Provisional; Region: PRK05431 266265003098 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 266265003099 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 266265003100 dimer interface [polypeptide binding]; other site 266265003101 active site 266265003102 motif 1; other site 266265003103 motif 2; other site 266265003104 motif 3; other site 266265003105 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 266265003106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265003107 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 266265003108 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266265003109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265003110 S-adenosylmethionine binding site [chemical binding]; other site 266265003111 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265003112 Ferritin-like domain; Region: Ferritin_2; pfam13668 266265003113 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266265003114 active site 266265003115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265003116 Coenzyme A binding pocket [chemical binding]; other site 266265003117 septum formation inhibitor; Reviewed; Region: PRK01973 266265003118 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 266265003119 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 266265003120 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 266265003121 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 266265003122 Switch I; other site 266265003123 Switch II; other site 266265003124 cell division topological specificity factor MinE; Provisional; Region: PRK13989 266265003125 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266265003126 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266265003127 putative active site [active] 266265003128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265003129 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265003130 putative substrate translocation pore; other site 266265003131 Gram-negative bacterial tonB protein; Region: TonB; cl10048 266265003132 argininosuccinate lyase; Provisional; Region: PRK00855 266265003133 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 266265003134 active sites [active] 266265003135 tetramer interface [polypeptide binding]; other site 266265003136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265003137 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265003138 sequence-specific DNA binding site [nucleotide binding]; other site 266265003139 salt bridge; other site 266265003140 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266265003141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265003142 S-adenosylmethionine binding site [chemical binding]; other site 266265003143 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 266265003144 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 266265003145 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 266265003146 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 266265003147 active site 266265003148 domain interfaces; other site 266265003149 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 266265003150 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 266265003151 active site 266265003152 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 266265003153 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 266265003154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265003155 TPR motif; other site 266265003156 binding surface 266265003157 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266265003158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265003159 putative substrate translocation pore; other site 266265003160 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 266265003161 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266265003162 putative NAD(P) binding site [chemical binding]; other site 266265003163 active site 266265003164 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265003165 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 266265003166 NAD(P) binding site [chemical binding]; other site 266265003167 catalytic residues [active] 266265003168 catalytic residues [active] 266265003169 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 266265003170 dimer interface [polypeptide binding]; other site 266265003171 substrate binding site [chemical binding]; other site 266265003172 metal binding sites [ion binding]; metal-binding site 266265003173 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265003174 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 266265003175 GIY-YIG motif/motif A; other site 266265003176 putative active site [active] 266265003177 putative metal binding site [ion binding]; other site 266265003178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 266265003179 Protein of unknown function, DUF482; Region: DUF482; pfam04339 266265003180 NAD synthetase; Provisional; Region: PRK13981 266265003181 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 266265003182 multimer interface [polypeptide binding]; other site 266265003183 active site 266265003184 catalytic triad [active] 266265003185 protein interface 1 [polypeptide binding]; other site 266265003186 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266265003187 homodimer interface [polypeptide binding]; other site 266265003188 NAD binding pocket [chemical binding]; other site 266265003189 ATP binding pocket [chemical binding]; other site 266265003190 Mg binding site [ion binding]; other site 266265003191 active-site loop [active] 266265003192 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 266265003193 Nitrogen regulatory protein P-II; Region: P-II; smart00938 266265003194 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265003195 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265003196 trimer interface [polypeptide binding]; other site 266265003197 eyelet of channel; other site 266265003198 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 266265003199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265003200 Walker A/P-loop; other site 266265003201 ATP binding site [chemical binding]; other site 266265003202 Q-loop/lid; other site 266265003203 ABC transporter signature motif; other site 266265003204 Walker B; other site 266265003205 D-loop; other site 266265003206 H-loop/switch region; other site 266265003207 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265003208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265003209 dimer interface [polypeptide binding]; other site 266265003210 conserved gate region; other site 266265003211 putative PBP binding loops; other site 266265003212 ABC-ATPase subunit interface; other site 266265003213 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265003214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265003215 dimer interface [polypeptide binding]; other site 266265003216 conserved gate region; other site 266265003217 putative PBP binding loops; other site 266265003218 ABC-ATPase subunit interface; other site 266265003219 Pirin-related protein [General function prediction only]; Region: COG1741 266265003220 Pirin; Region: Pirin; pfam02678 266265003221 Heavy-metal resistance; Region: Metal_resist; pfam13801 266265003222 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265003223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265003224 active site 266265003225 phosphorylation site [posttranslational modification] 266265003226 intermolecular recognition site; other site 266265003227 dimerization interface [polypeptide binding]; other site 266265003228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265003229 DNA binding site [nucleotide binding] 266265003230 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 266265003231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265003232 dimer interface [polypeptide binding]; other site 266265003233 phosphorylation site [posttranslational modification] 266265003234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265003235 ATP binding site [chemical binding]; other site 266265003236 Mg2+ binding site [ion binding]; other site 266265003237 G-X-G motif; other site 266265003238 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 266265003239 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265003240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265003241 metal binding site [ion binding]; metal-binding site 266265003242 active site 266265003243 I-site; other site 266265003244 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 266265003245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265003246 dimer interface [polypeptide binding]; other site 266265003247 conserved gate region; other site 266265003248 putative PBP binding loops; other site 266265003249 ABC-ATPase subunit interface; other site 266265003250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265003251 dimer interface [polypeptide binding]; other site 266265003252 conserved gate region; other site 266265003253 putative PBP binding loops; other site 266265003254 ABC-ATPase subunit interface; other site 266265003255 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265003256 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265003257 Walker A/P-loop; other site 266265003258 ATP binding site [chemical binding]; other site 266265003259 Q-loop/lid; other site 266265003260 ABC transporter signature motif; other site 266265003261 Walker B; other site 266265003262 D-loop; other site 266265003263 H-loop/switch region; other site 266265003264 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 266265003265 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 266265003266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265003267 Walker A motif; other site 266265003268 ATP binding site [chemical binding]; other site 266265003269 Walker B motif; other site 266265003270 arginine finger; other site 266265003271 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265003272 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 266265003273 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266265003274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265003275 active site 266265003276 phosphorylation site [posttranslational modification] 266265003277 intermolecular recognition site; other site 266265003278 dimerization interface [polypeptide binding]; other site 266265003279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265003280 Walker A motif; other site 266265003281 ATP binding site [chemical binding]; other site 266265003282 Walker B motif; other site 266265003283 arginine finger; other site 266265003284 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265003285 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266265003286 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 266265003287 active site 266265003288 homotetramer interface [polypeptide binding]; other site 266265003289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265003290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265003291 putative substrate translocation pore; other site 266265003292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265003293 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 266265003294 substrate binding site [chemical binding]; other site 266265003295 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 266265003296 additional DNA contacts [nucleotide binding]; other site 266265003297 mismatch recognition site; other site 266265003298 active site 266265003299 zinc binding site [ion binding]; other site 266265003300 DNA intercalation site [nucleotide binding]; other site 266265003301 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265003302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265003303 DNA-binding site [nucleotide binding]; DNA binding site 266265003304 FCD domain; Region: FCD; pfam07729 266265003305 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265003306 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265003307 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 266265003308 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266265003309 phosphate binding site [ion binding]; other site 266265003310 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 266265003311 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266265003312 classical (c) SDRs; Region: SDR_c; cd05233 266265003313 NAD(P) binding site [chemical binding]; other site 266265003314 active site 266265003315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265003316 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265003317 putative substrate translocation pore; other site 266265003318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265003319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265003320 putative substrate translocation pore; other site 266265003321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265003322 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266265003323 NAD(P) binding site [chemical binding]; other site 266265003324 active site 266265003325 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265003326 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265003327 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265003328 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265003329 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266265003330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265003331 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 266265003332 putative effector binding pocket; other site 266265003333 putative dimerization interface [polypeptide binding]; other site 266265003334 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266265003335 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 266265003336 putative active site pocket [active] 266265003337 metal binding site [ion binding]; metal-binding site 266265003338 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 266265003339 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266265003340 malic enzyme; Reviewed; Region: PRK12862 266265003341 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266265003342 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266265003343 putative NAD(P) binding site [chemical binding]; other site 266265003344 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266265003345 DNA cytosine methylase; Provisional; Region: PRK10458 266265003346 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 266265003347 cofactor binding site; other site 266265003348 DNA binding site [nucleotide binding] 266265003349 substrate interaction site [chemical binding]; other site 266265003350 CsbD-like; Region: CsbD; pfam05532 266265003351 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265003352 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266265003353 C-terminal domain interface [polypeptide binding]; other site 266265003354 GSH binding site (G-site) [chemical binding]; other site 266265003355 dimer interface [polypeptide binding]; other site 266265003356 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 266265003357 dimer interface [polypeptide binding]; other site 266265003358 N-terminal domain interface [polypeptide binding]; other site 266265003359 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266265003360 Methyltransferase domain; Region: Methyltransf_12; pfam08242 266265003361 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265003362 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266265003363 Rubredoxin; Region: Rubredoxin; pfam00301 266265003364 iron binding site [ion binding]; other site 266265003365 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 266265003366 ABC transporter ATPase component; Reviewed; Region: PRK11147 266265003367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265003368 Walker A/P-loop; other site 266265003369 ATP binding site [chemical binding]; other site 266265003370 Q-loop/lid; other site 266265003371 ABC transporter signature motif; other site 266265003372 Walker B; other site 266265003373 D-loop; other site 266265003374 H-loop/switch region; other site 266265003375 ABC transporter; Region: ABC_tran_2; pfam12848 266265003376 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265003377 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 266265003378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265003379 ATP binding site [chemical binding]; other site 266265003380 Mg2+ binding site [ion binding]; other site 266265003381 G-X-G motif; other site 266265003382 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 266265003383 anchoring element; other site 266265003384 dimer interface [polypeptide binding]; other site 266265003385 ATP binding site [chemical binding]; other site 266265003386 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266265003387 active site 266265003388 metal binding site [ion binding]; metal-binding site 266265003389 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 266265003390 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 266265003391 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266265003392 CAP-like domain; other site 266265003393 active site 266265003394 primary dimer interface [polypeptide binding]; other site 266265003395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266265003396 Predicted integral membrane protein [Function unknown]; Region: COG5615 266265003397 Chromate transporter; Region: Chromate_transp; pfam02417 266265003398 Chromate transporter; Region: Chromate_transp; pfam02417 266265003399 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265003400 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265003401 metal binding site [ion binding]; metal-binding site 266265003402 active site 266265003403 I-site; other site 266265003404 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265003405 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 266265003406 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266265003407 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266265003408 homotrimer interaction site [polypeptide binding]; other site 266265003409 putative active site [active] 266265003410 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 266265003411 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265003412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265003413 homodimer interface [polypeptide binding]; other site 266265003414 catalytic residue [active] 266265003415 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 266265003416 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265003417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265003418 DNA-binding site [nucleotide binding]; DNA binding site 266265003419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265003420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265003421 homodimer interface [polypeptide binding]; other site 266265003422 catalytic residue [active] 266265003423 heat shock protein 90; Provisional; Region: PRK05218 266265003424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265003425 ATP binding site [chemical binding]; other site 266265003426 Mg2+ binding site [ion binding]; other site 266265003427 G-X-G motif; other site 266265003428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266265003429 TPR motif; other site 266265003430 binding surface 266265003431 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265003432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265003433 binding surface 266265003434 TPR motif; other site 266265003435 Tetratricopeptide repeat; Region: TPR_12; pfam13424 266265003436 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265003437 Chorismate lyase; Region: Chor_lyase; cl01230 266265003438 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 266265003439 putative active site [active] 266265003440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266265003441 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 266265003442 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 266265003443 Na binding site [ion binding]; other site 266265003444 Predicted membrane protein [Function unknown]; Region: COG1289 266265003445 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265003446 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266265003447 dimer interface [polypeptide binding]; other site 266265003448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265003449 transaldolase-like protein; Provisional; Region: PTZ00411 266265003450 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 266265003451 active site 266265003452 dimer interface [polypeptide binding]; other site 266265003453 catalytic residue [active] 266265003454 Benzoate membrane transport protein; Region: BenE; pfam03594 266265003455 benzoate transporter; Region: benE; TIGR00843 266265003456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 266265003457 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266265003458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265003459 Walker A motif; other site 266265003460 ATP binding site [chemical binding]; other site 266265003461 Walker B motif; other site 266265003462 arginine finger; other site 266265003463 Cytochrome c; Region: Cytochrom_C; cl11414 266265003464 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265003465 Cytochrome c; Region: Cytochrom_C; cl11414 266265003466 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 266265003467 endonuclease III; Provisional; Region: PRK10702 266265003468 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266265003469 minor groove reading motif; other site 266265003470 helix-hairpin-helix signature motif; other site 266265003471 substrate binding pocket [chemical binding]; other site 266265003472 active site 266265003473 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 266265003474 ferredoxin; Provisional; Region: PRK06991 266265003475 Putative Fe-S cluster; Region: FeS; pfam04060 266265003476 4Fe-4S binding domain; Region: Fer4; pfam00037 266265003477 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266265003478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265003479 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 266265003480 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 266265003481 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 266265003482 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266265003483 Protein of unknown function (DUF3096); Region: DUF3096; pfam11295 266265003484 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 266265003485 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266265003486 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 266265003487 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 266265003488 META domain; Region: META; pfam03724 266265003489 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 266265003490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265003491 ATP-grasp domain; Region: ATP-grasp; pfam02222 266265003492 Predicted periplasmic protein [General function prediction only]; Region: COG3895 266265003493 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 266265003494 acetolactate synthase; Reviewed; Region: PRK08322 266265003495 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265003496 PYR/PP interface [polypeptide binding]; other site 266265003497 dimer interface [polypeptide binding]; other site 266265003498 TPP binding site [chemical binding]; other site 266265003499 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265003500 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 266265003501 TPP-binding site [chemical binding]; other site 266265003502 dimer interface [polypeptide binding]; other site 266265003503 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 266265003504 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265003505 NAD(P) binding site [chemical binding]; other site 266265003506 catalytic residues [active] 266265003507 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 266265003508 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266265003509 ATP binding site [chemical binding]; other site 266265003510 Mg++ binding site [ion binding]; other site 266265003511 motif III; other site 266265003512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265003513 nucleotide binding region [chemical binding]; other site 266265003514 ATP-binding site [chemical binding]; other site 266265003515 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 266265003516 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 266265003517 active site 266265003518 HIGH motif; other site 266265003519 nucleotide binding site [chemical binding]; other site 266265003520 active site 266265003521 KMSKS motif; other site 266265003522 rhodanese superfamily protein; Provisional; Region: PRK05320 266265003523 Acylphosphatase; Region: Acylphosphatase; cl00551 266265003524 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 266265003525 active site residue [active] 266265003526 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 266265003527 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 266265003528 putative active site [active] 266265003529 putative PHP Thumb interface [polypeptide binding]; other site 266265003530 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266265003531 generic binding surface II; other site 266265003532 generic binding surface I; other site 266265003533 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 266265003534 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266265003535 putative metal binding site; other site 266265003536 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 266265003537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266265003538 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 266265003539 Walker A/P-loop; other site 266265003540 ATP binding site [chemical binding]; other site 266265003541 Q-loop/lid; other site 266265003542 ABC transporter signature motif; other site 266265003543 Walker B; other site 266265003544 D-loop; other site 266265003545 H-loop/switch region; other site 266265003546 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 266265003547 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265003548 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266265003549 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266265003550 putative active site [active] 266265003551 O-Antigen ligase; Region: Wzy_C; cl04850 266265003552 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 266265003553 putative ADP-binding pocket [chemical binding]; other site 266265003554 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265003555 recombination associated protein; Reviewed; Region: rdgC; PRK00321 266265003556 acid-resistance membrane protein; Provisional; Region: PRK10209 266265003557 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266265003558 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266265003559 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266265003560 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266265003561 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266265003562 H+ Antiporter protein; Region: 2A0121; TIGR00900 266265003563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265003564 putative substrate translocation pore; other site 266265003565 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 266265003566 dimer interface [polypeptide binding]; other site 266265003567 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 266265003568 putative dimer interface [polypeptide binding]; other site 266265003569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265003570 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 266265003571 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 266265003572 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 266265003573 NlpC/P60 family; Region: NLPC_P60; cl17555 266265003574 molybdenum-pterin binding domain; Region: Mop; TIGR00638 266265003575 TOBE domain; Region: TOBE; cl01440 266265003576 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 266265003577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265003578 PAS domain; Region: PAS_9; pfam13426 266265003579 putative active site [active] 266265003580 heme pocket [chemical binding]; other site 266265003581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265003582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265003583 metal binding site [ion binding]; metal-binding site 266265003584 active site 266265003585 I-site; other site 266265003586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265003587 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 266265003588 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266265003589 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266265003590 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265003591 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 266265003592 ribonuclease G; Provisional; Region: PRK11712 266265003593 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266265003594 homodimer interface [polypeptide binding]; other site 266265003595 oligonucleotide binding site [chemical binding]; other site 266265003596 Maf-like protein; Region: Maf; pfam02545 266265003597 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266265003598 active site 266265003599 dimer interface [polypeptide binding]; other site 266265003600 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 266265003601 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 266265003602 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 266265003603 active site 266265003604 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 266265003605 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 266265003606 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 266265003607 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 266265003608 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 266265003609 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 266265003610 hypothetical protein; Validated; Region: PRK00110 266265003611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265003612 active site 266265003613 short chain dehydrogenase; Provisional; Region: PRK08339 266265003614 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266265003615 putative NAD(P) binding site [chemical binding]; other site 266265003616 putative active site [active] 266265003617 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 266265003618 active site 266265003619 dimer interfaces [polypeptide binding]; other site 266265003620 catalytic residues [active] 266265003621 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 266265003622 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266265003623 NADP binding site [chemical binding]; other site 266265003624 dimer interface [polypeptide binding]; other site 266265003625 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 266265003626 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 266265003627 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266265003628 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 266265003629 sensor protein KdpD; Provisional; Region: PRK10490 266265003630 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 266265003631 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 266265003632 Ligand Binding Site [chemical binding]; other site 266265003633 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 266265003634 GAF domain; Region: GAF_3; pfam13492 266265003635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265003636 dimer interface [polypeptide binding]; other site 266265003637 phosphorylation site [posttranslational modification] 266265003638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265003639 ATP binding site [chemical binding]; other site 266265003640 Mg2+ binding site [ion binding]; other site 266265003641 G-X-G motif; other site 266265003642 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 266265003643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265003644 active site 266265003645 phosphorylation site [posttranslational modification] 266265003646 intermolecular recognition site; other site 266265003647 dimerization interface [polypeptide binding]; other site 266265003648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265003649 DNA binding site [nucleotide binding] 266265003650 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 266265003651 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 266265003652 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 266265003653 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 266265003654 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 266265003655 apolar tunnel; other site 266265003656 heme binding site [chemical binding]; other site 266265003657 dimerization interface [polypeptide binding]; other site 266265003658 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 266265003659 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266265003660 glucose-1-dehydrogenase; Provisional; Region: PRK06947 266265003661 classical (c) SDRs; Region: SDR_c; cd05233 266265003662 NAD(P) binding site [chemical binding]; other site 266265003663 active site 266265003664 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 266265003665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265003666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265003667 Bacterial transcriptional repressor; Region: TetR; pfam13972 266265003668 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 266265003669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265003670 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 266265003671 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266265003672 putative active site [active] 266265003673 putative metal binding site [ion binding]; other site 266265003674 RDD family; Region: RDD; pfam06271 266265003675 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 266265003676 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 266265003677 RNA polymerase factor sigma-70; Validated; Region: PRK09047 266265003678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265003679 DNA binding residues [nucleotide binding] 266265003680 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 266265003681 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265003682 PYR/PP interface [polypeptide binding]; other site 266265003683 dimer interface [polypeptide binding]; other site 266265003684 TPP binding site [chemical binding]; other site 266265003685 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265003686 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 266265003687 TPP-binding site [chemical binding]; other site 266265003688 dimer interface [polypeptide binding]; other site 266265003689 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 266265003690 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 266265003691 putative valine binding site [chemical binding]; other site 266265003692 dimer interface [polypeptide binding]; other site 266265003693 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 266265003694 ketol-acid reductoisomerase; Provisional; Region: PRK05479 266265003695 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 266265003696 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 266265003697 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 266265003698 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 266265003699 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266265003700 2-isopropylmalate synthase; Validated; Region: PRK00915 266265003701 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 266265003702 active site 266265003703 catalytic residues [active] 266265003704 metal binding site [ion binding]; metal-binding site 266265003705 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266265003706 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266265003707 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266265003708 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 266265003709 active site clefts [active] 266265003710 zinc binding site [ion binding]; other site 266265003711 dimer interface [polypeptide binding]; other site 266265003712 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 266265003713 16S/18S rRNA binding site [nucleotide binding]; other site 266265003714 S13e-L30e interaction site [polypeptide binding]; other site 266265003715 25S rRNA binding site [nucleotide binding]; other site 266265003716 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 266265003717 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 266265003718 RNase E interface [polypeptide binding]; other site 266265003719 trimer interface [polypeptide binding]; other site 266265003720 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 266265003721 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 266265003722 RNase E interface [polypeptide binding]; other site 266265003723 trimer interface [polypeptide binding]; other site 266265003724 active site 266265003725 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 266265003726 putative nucleic acid binding region [nucleotide binding]; other site 266265003727 G-X-X-G motif; other site 266265003728 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 266265003729 RNA binding site [nucleotide binding]; other site 266265003730 domain interface; other site 266265003731 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 266265003732 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 266265003733 NAD(P) binding site [chemical binding]; other site 266265003734 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 266265003735 triosephosphate isomerase; Provisional; Region: PRK14567 266265003736 substrate binding site [chemical binding]; other site 266265003737 dimer interface [polypeptide binding]; other site 266265003738 catalytic triad [active] 266265003739 Preprotein translocase SecG subunit; Region: SecG; pfam03840 266265003740 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 266265003741 NADH dehydrogenase subunit B; Validated; Region: PRK06411 266265003742 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 266265003743 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 266265003744 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 266265003745 NADH dehydrogenase subunit D; Validated; Region: PRK06075 266265003746 NADH dehydrogenase subunit E; Validated; Region: PRK07539 266265003747 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 266265003748 putative dimer interface [polypeptide binding]; other site 266265003749 [2Fe-2S] cluster binding site [ion binding]; other site 266265003750 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266265003751 SLBB domain; Region: SLBB; pfam10531 266265003752 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 266265003753 NADH dehydrogenase subunit G; Validated; Region: PRK09129 266265003754 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265003755 catalytic loop [active] 266265003756 iron binding site [ion binding]; other site 266265003757 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 266265003758 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 266265003759 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 266265003760 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 266265003761 4Fe-4S binding domain; Region: Fer4; cl02805 266265003762 4Fe-4S binding domain; Region: Fer4; pfam00037 266265003763 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 266265003764 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 266265003765 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 266265003766 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 266265003767 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 266265003768 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266265003769 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 266265003770 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266265003771 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 266265003772 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266265003773 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 266265003774 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 266265003775 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266265003776 dimer interface [polypeptide binding]; other site 266265003777 ADP-ribose binding site [chemical binding]; other site 266265003778 active site 266265003779 nudix motif; other site 266265003780 metal binding site [ion binding]; metal-binding site 266265003781 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265003782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 266265003783 DNA binding site [nucleotide binding] 266265003784 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 266265003785 DNA binding site [nucleotide binding] 266265003786 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 266265003787 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266265003788 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 266265003789 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 266265003790 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 266265003791 active site 266265003792 REJ domain; Region: REJ; pfam02010 266265003793 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 266265003794 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 266265003795 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 266265003796 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266265003797 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 266265003798 FAD binding site [chemical binding]; other site 266265003799 substrate binding site [chemical binding]; other site 266265003800 catalytic base [active] 266265003801 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266265003802 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266265003803 active site 266265003804 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 266265003805 putative active site [active] 266265003806 putative catalytic site [active] 266265003807 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 266265003808 putative active site [active] 266265003809 putative catalytic site [active] 266265003810 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265003811 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 266265003812 FAD binding site [chemical binding]; other site 266265003813 substrate binding site [chemical binding]; other site 266265003814 catalytic base [active] 266265003815 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266265003816 putative active site [active] 266265003817 putative substrate binding site [chemical binding]; other site 266265003818 ATP binding site [chemical binding]; other site 266265003819 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266265003820 catalytic core [active] 266265003821 enoyl-CoA hydratase; Provisional; Region: PRK07511 266265003822 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265003823 substrate binding site [chemical binding]; other site 266265003824 oxyanion hole (OAH) forming residues; other site 266265003825 trimer interface [polypeptide binding]; other site 266265003826 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 266265003827 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265003828 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265003829 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265003830 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 266265003831 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265003832 C-terminal domain interface [polypeptide binding]; other site 266265003833 GSH binding site (G-site) [chemical binding]; other site 266265003834 dimer interface [polypeptide binding]; other site 266265003835 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266265003836 N-terminal domain interface [polypeptide binding]; other site 266265003837 dimer interface [polypeptide binding]; other site 266265003838 substrate binding pocket (H-site) [chemical binding]; other site 266265003839 methionine aminotransferase; Validated; Region: PRK09082 266265003840 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265003841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265003842 homodimer interface [polypeptide binding]; other site 266265003843 catalytic residue [active] 266265003844 PIN domain; Region: PIN_3; pfam13470 266265003845 hypothetical protein; Validated; Region: PRK02101 266265003846 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 266265003847 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 266265003848 putative active site [active] 266265003849 Zn binding site [ion binding]; other site 266265003850 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 266265003851 Predicted membrane protein [Function unknown]; Region: COG3235 266265003852 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265003853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 266265003854 active site 266265003855 phosphorylation site [posttranslational modification] 266265003856 intermolecular recognition site; other site 266265003857 dimerization interface [polypeptide binding]; other site 266265003858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265003859 DNA binding residues [nucleotide binding] 266265003860 dimerization interface [polypeptide binding]; other site 266265003861 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 266265003862 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 266265003863 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266265003864 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 266265003865 transposase; Validated; Region: PRK08181 266265003866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265003867 Walker A motif; other site 266265003868 ATP binding site [chemical binding]; other site 266265003869 Walker B motif; other site 266265003870 arginine finger; other site 266265003871 Integrase core domain; Region: rve; pfam00665 266265003872 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265003873 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265003874 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265003875 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265003876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265003877 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265003878 Transposase; Region: HTH_Tnp_1; pfam01527 266265003879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265003880 Uncharacterized conserved protein [Function unknown]; Region: COG4544 266265003881 DNA Polymerase Y-family; Region: PolY_like; cd03468 266265003882 DNA binding site [nucleotide binding] 266265003883 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 266265003884 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 266265003885 putative active site [active] 266265003886 putative PHP Thumb interface [polypeptide binding]; other site 266265003887 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 266265003888 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 266265003889 generic binding surface II; other site 266265003890 generic binding surface I; other site 266265003891 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 266265003892 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 266265003893 NADP binding site [chemical binding]; other site 266265003894 active site 266265003895 putative substrate binding site [chemical binding]; other site 266265003896 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266265003897 metal-binding site [ion binding] 266265003898 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266265003899 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 266265003900 DNA binding residues [nucleotide binding] 266265003901 dimer interface [polypeptide binding]; other site 266265003902 copper binding site [ion binding]; other site 266265003903 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265003904 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265003905 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 266265003906 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 266265003907 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265003908 active site 266265003909 catalytic tetrad [active] 266265003910 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 266265003911 classical (c) SDRs; Region: SDR_c; cd05233 266265003912 NAD(P) binding site [chemical binding]; other site 266265003913 active site 266265003914 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266265003915 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266265003916 nucleophile elbow; other site 266265003917 Patatin phospholipase; Region: DUF3734; pfam12536 266265003918 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 266265003919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265003920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265003921 homodimer interface [polypeptide binding]; other site 266265003922 catalytic residue [active] 266265003923 excinuclease ABC subunit B; Provisional; Region: PRK05298 266265003924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265003925 ATP binding site [chemical binding]; other site 266265003926 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265003927 nucleotide binding region [chemical binding]; other site 266265003928 ATP-binding site [chemical binding]; other site 266265003929 Ultra-violet resistance protein B; Region: UvrB; pfam12344 266265003930 UvrB/uvrC motif; Region: UVR; pfam02151 266265003931 Fe2+ transport protein; Region: Iron_transport; pfam10634 266265003932 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 266265003933 Iron permease FTR1 family; Region: FTR1; cl00475 266265003934 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 266265003935 4Fe-4S binding domain; Region: Fer4_5; pfam12801 266265003936 Hemin uptake protein hemP; Region: hemP; pfam10636 266265003937 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 266265003938 putative hydrophobic ligand binding site [chemical binding]; other site 266265003939 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 266265003940 Pirin-related protein [General function prediction only]; Region: COG1741 266265003941 Pirin; Region: Pirin; pfam02678 266265003942 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266265003943 LysR family transcriptional regulator; Provisional; Region: PRK14997 266265003944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265003945 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 266265003946 putative effector binding pocket; other site 266265003947 putative dimerization interface [polypeptide binding]; other site 266265003948 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265003949 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266265003950 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 266265003951 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266265003952 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 266265003953 glutamate racemase; Provisional; Region: PRK00865 266265003954 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 266265003955 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 266265003956 heme binding site [chemical binding]; other site 266265003957 ferroxidase pore; other site 266265003958 ferroxidase diiron center [ion binding]; other site 266265003959 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 266265003960 Fumarase C-terminus; Region: Fumerase_C; pfam05683 266265003961 hypothetical protein; Provisional; Region: PRK05208 266265003962 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 266265003963 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266265003964 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266265003965 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 266265003966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265003967 binding surface 266265003968 TPR motif; other site 266265003969 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 266265003970 Flagellar assembly protein FliH; Region: FliH; pfam02108 266265003971 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 266265003972 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 266265003973 type III secretion system protein YscR; Provisional; Region: PRK12797 266265003974 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 266265003975 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 266265003976 FHIPEP family; Region: FHIPEP; pfam00771 266265003977 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 266265003978 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 266265003979 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265003980 Walker A motif; other site 266265003981 ATP binding site [chemical binding]; other site 266265003982 Walker B motif; other site 266265003983 Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481 266265003984 acetyl-CoA synthetase; Provisional; Region: PRK00174 266265003985 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 266265003986 active site 266265003987 CoA binding site [chemical binding]; other site 266265003988 acyl-activating enzyme (AAE) consensus motif; other site 266265003989 AMP binding site [chemical binding]; other site 266265003990 acetate binding site [chemical binding]; other site 266265003991 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 266265003992 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 266265003993 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 266265003994 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 266265003995 dimer interface [polypeptide binding]; other site 266265003996 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266265003997 active site 266265003998 Int/Topo IB signature motif; other site 266265003999 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 266265004000 Small T antigen; Reviewed; Region: PHA03102 266265004001 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 266265004002 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 266265004003 putative NHN endonuclease; Region: PHA00280 266265004004 ParB-like nuclease domain; Region: ParB; smart00470 266265004005 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 266265004006 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 266265004007 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Region: AceE; COG2609 266265004008 Protein of unknown function (DUF968); Region: DUF968; pfam06147 266265004009 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 266265004010 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 266265004011 gpW; Region: gpW; pfam02831 266265004012 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 266265004013 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 266265004014 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 266265004015 tandem repeat interface [polypeptide binding]; other site 266265004016 oligomer interface [polypeptide binding]; other site 266265004017 active site residues [active] 266265004018 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 266265004019 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 266265004020 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 266265004021 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 266265004022 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 266265004023 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 266265004024 Phage tail tube protein; Region: Tail_tube; pfam10618 266265004025 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 266265004026 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 266265004027 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 266265004028 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 266265004029 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 266265004030 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 266265004031 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 266265004032 Phage protein GP46; Region: GP46; pfam07409 266265004033 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 266265004034 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 266265004035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266265004036 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 266265004037 catalytic residue [active] 266265004038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 266265004039 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266265004040 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 266265004041 active site 266265004042 nucleophile elbow; other site 266265004043 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265004044 substrate binding pocket [chemical binding]; other site 266265004045 membrane-bound complex binding site; other site 266265004046 hinge residues; other site 266265004047 CHASE domain; Region: CHASE; pfam03924 266265004048 PAS domain S-box; Region: sensory_box; TIGR00229 266265004049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265004050 putative active site [active] 266265004051 heme pocket [chemical binding]; other site 266265004052 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265004053 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265004054 metal binding site [ion binding]; metal-binding site 266265004055 active site 266265004056 I-site; other site 266265004057 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265004058 Methyltransferase domain; Region: Methyltransf_12; pfam08242 266265004059 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266265004060 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265004061 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 266265004062 enterobactin exporter EntS; Provisional; Region: PRK10489 266265004063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004064 putative substrate translocation pore; other site 266265004065 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265004066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004067 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265004068 dimerization interface [polypeptide binding]; other site 266265004069 substrate binding pocket [chemical binding]; other site 266265004070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004071 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265004072 putative substrate translocation pore; other site 266265004073 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 266265004074 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265004075 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 266265004076 active site 266265004077 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266265004078 EamA-like transporter family; Region: EamA; pfam00892 266265004079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004081 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265004082 putative effector binding pocket; other site 266265004083 dimerization interface [polypeptide binding]; other site 266265004084 L-asparaginase II; Region: Asparaginase_II; pfam06089 266265004085 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 266265004086 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 266265004087 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266265004088 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 266265004089 PAAR motif; Region: PAAR_motif; pfam05488 266265004090 PAAR motif; Region: PAAR_motif; pfam05488 266265004091 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 266265004092 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265004093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265004094 active site 266265004095 phosphorylation site [posttranslational modification] 266265004096 intermolecular recognition site; other site 266265004097 dimerization interface [polypeptide binding]; other site 266265004098 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 266265004099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265004100 TPR motif; other site 266265004101 TPR repeat; Region: TPR_11; pfam13414 266265004102 binding surface 266265004103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265004104 binding surface 266265004105 TPR repeat; Region: TPR_11; pfam13414 266265004106 TPR motif; other site 266265004107 TPR repeat; Region: TPR_11; pfam13414 266265004108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265004109 binding surface 266265004110 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265004111 TPR motif; other site 266265004112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265004113 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265004114 active site 266265004115 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265004116 catalytic tetrad [active] 266265004117 short chain dehydrogenase; Provisional; Region: PRK08263 266265004118 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265004119 NADP binding site [chemical binding]; other site 266265004120 active site 266265004121 steroid binding site; other site 266265004122 short chain dehydrogenase; Provisional; Region: PRK12937 266265004123 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 266265004124 NADP binding site [chemical binding]; other site 266265004125 homodimer interface [polypeptide binding]; other site 266265004126 active site 266265004127 substrate binding site [chemical binding]; other site 266265004128 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004130 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266265004131 putative effector binding pocket; other site 266265004132 putative dimerization interface [polypeptide binding]; other site 266265004133 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 266265004134 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 266265004135 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 266265004136 putative dimer interface [polypeptide binding]; other site 266265004137 N-terminal domain interface [polypeptide binding]; other site 266265004138 putative substrate binding pocket (H-site) [chemical binding]; other site 266265004139 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 266265004140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265004142 dimerization interface [polypeptide binding]; other site 266265004143 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 266265004144 generic binding surface I; other site 266265004145 generic binding surface II; other site 266265004146 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266265004147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004148 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265004149 dimerization interface [polypeptide binding]; other site 266265004150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265004151 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265004152 active site 266265004153 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265004154 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265004155 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265004156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004157 putative substrate translocation pore; other site 266265004158 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 266265004159 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266265004160 aspartate racemase; Region: asp_race; TIGR00035 266265004161 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 266265004162 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266265004163 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266265004164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265004165 Walker A/P-loop; other site 266265004166 ATP binding site [chemical binding]; other site 266265004167 Q-loop/lid; other site 266265004168 ABC transporter signature motif; other site 266265004169 Walker B; other site 266265004170 D-loop; other site 266265004171 H-loop/switch region; other site 266265004172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265004173 Walker A/P-loop; other site 266265004174 ATP binding site [chemical binding]; other site 266265004175 Q-loop/lid; other site 266265004176 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266265004177 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266265004178 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266265004179 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266265004180 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 266265004181 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265004182 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266265004183 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265004184 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266265004185 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266265004186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265004187 non-specific DNA binding site [nucleotide binding]; other site 266265004188 salt bridge; other site 266265004189 sequence-specific DNA binding site [nucleotide binding]; other site 266265004190 Cupin domain; Region: Cupin_2; pfam07883 266265004191 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 266265004192 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 266265004193 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 266265004194 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266265004195 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266265004196 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 266265004197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265004198 dimer interface [polypeptide binding]; other site 266265004199 conserved gate region; other site 266265004200 putative PBP binding loops; other site 266265004201 ABC-ATPase subunit interface; other site 266265004202 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266265004203 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 266265004204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265004205 dimer interface [polypeptide binding]; other site 266265004206 conserved gate region; other site 266265004207 putative PBP binding loops; other site 266265004208 ABC-ATPase subunit interface; other site 266265004209 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266265004210 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265004211 Walker A/P-loop; other site 266265004212 ATP binding site [chemical binding]; other site 266265004213 Q-loop/lid; other site 266265004214 ABC transporter signature motif; other site 266265004215 Walker B; other site 266265004216 D-loop; other site 266265004217 H-loop/switch region; other site 266265004218 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265004219 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265004220 Walker A/P-loop; other site 266265004221 ATP binding site [chemical binding]; other site 266265004222 Q-loop/lid; other site 266265004223 ABC transporter signature motif; other site 266265004224 Walker B; other site 266265004225 D-loop; other site 266265004226 H-loop/switch region; other site 266265004227 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265004228 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 266265004229 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 266265004230 putative acetyltransferase YhhY; Provisional; Region: PRK10140 266265004231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265004232 Coenzyme A binding pocket [chemical binding]; other site 266265004233 putative acetyltransferase YhhY; Provisional; Region: PRK10140 266265004234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265004235 Coenzyme A binding pocket [chemical binding]; other site 266265004236 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266265004237 Protein export membrane protein; Region: SecD_SecF; cl14618 266265004238 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265004239 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266265004240 conserved cys residue [active] 266265004241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265004242 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 266265004243 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 266265004244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265004247 dimerization interface [polypeptide binding]; other site 266265004248 Uncharacterized conserved protein [Function unknown]; Region: COG3868 266265004249 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 266265004250 putative active site [active] 266265004251 Tetratricopeptide repeat; Region: TPR_15; pfam13429 266265004252 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 266265004253 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 266265004254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265004255 Predicted membrane protein [Function unknown]; Region: COG4267 266265004256 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 266265004257 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 266265004258 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266265004259 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266265004260 Lysine efflux permease [General function prediction only]; Region: COG1279 266265004261 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 266265004262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004263 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265004264 dimerization interface [polypeptide binding]; other site 266265004265 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266265004266 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265004267 dimerization interface [polypeptide binding]; other site 266265004268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265004269 dimer interface [polypeptide binding]; other site 266265004270 phosphorylation site [posttranslational modification] 266265004271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265004272 ATP binding site [chemical binding]; other site 266265004273 Mg2+ binding site [ion binding]; other site 266265004274 G-X-G motif; other site 266265004275 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266265004276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265004277 active site 266265004278 phosphorylation site [posttranslational modification] 266265004279 intermolecular recognition site; other site 266265004280 dimerization interface [polypeptide binding]; other site 266265004281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265004282 DNA binding site [nucleotide binding] 266265004283 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266265004284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265004285 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004287 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 266265004288 putative dimerization interface [polypeptide binding]; other site 266265004289 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266265004290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265004292 dimerization interface [polypeptide binding]; other site 266265004293 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266265004294 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266265004295 metal binding site [ion binding]; metal-binding site 266265004296 putative dimer interface [polypeptide binding]; other site 266265004297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004298 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265004299 putative substrate translocation pore; other site 266265004300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265004302 putative substrate translocation pore; other site 266265004303 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 266265004304 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265004305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265004306 NAD(P) binding site [chemical binding]; other site 266265004307 active site 266265004308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265004311 dimerization interface [polypeptide binding]; other site 266265004312 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266265004313 active sites [active] 266265004314 tetramer interface [polypeptide binding]; other site 266265004315 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266265004316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265004317 DNA-binding site [nucleotide binding]; DNA binding site 266265004318 UTRA domain; Region: UTRA; pfam07702 266265004319 urocanate hydratase; Provisional; Region: PRK05414 266265004320 HutD; Region: HutD; pfam05962 266265004321 imidazolonepropionase; Validated; Region: PRK09356 266265004322 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 266265004323 active site 266265004324 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 266265004325 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 266265004326 active site 266265004327 N-formylglutamate amidohydrolase; Region: FGase; cl01522 266265004328 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 266265004329 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266265004330 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266265004331 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265004332 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266265004333 dimerization interface [polypeptide binding]; other site 266265004334 ligand binding site [chemical binding]; other site 266265004335 pyridoxamine kinase; Validated; Region: PRK05756 266265004336 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 266265004337 dimer interface [polypeptide binding]; other site 266265004338 pyridoxal binding site [chemical binding]; other site 266265004339 ATP binding site [chemical binding]; other site 266265004340 glycogen synthase; Provisional; Region: glgA; PRK00654 266265004341 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 266265004342 ADP-binding pocket [chemical binding]; other site 266265004343 homodimer interface [polypeptide binding]; other site 266265004344 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 266265004345 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 266265004346 ligand binding site; other site 266265004347 oligomer interface; other site 266265004348 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 266265004349 dimer interface [polypeptide binding]; other site 266265004350 N-terminal domain interface [polypeptide binding]; other site 266265004351 sulfate 1 binding site; other site 266265004352 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 266265004353 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265004354 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 266265004355 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266265004356 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266265004357 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 266265004358 active site residue [active] 266265004359 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 266265004360 active site residue [active] 266265004361 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 266265004362 active site residue [active] 266265004363 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 266265004364 active site residue [active] 266265004365 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 266265004366 hypothetical protein; Provisional; Region: PRK10279 266265004367 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266265004368 active site 266265004369 nucleophile elbow; other site 266265004370 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265004371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265004372 dimer interface [polypeptide binding]; other site 266265004373 conserved gate region; other site 266265004374 putative PBP binding loops; other site 266265004375 ABC-ATPase subunit interface; other site 266265004376 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265004377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265004378 dimer interface [polypeptide binding]; other site 266265004379 conserved gate region; other site 266265004380 putative PBP binding loops; other site 266265004381 ABC-ATPase subunit interface; other site 266265004382 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 266265004383 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265004384 Walker A/P-loop; other site 266265004385 ATP binding site [chemical binding]; other site 266265004386 Q-loop/lid; other site 266265004387 ABC transporter signature motif; other site 266265004388 Walker B; other site 266265004389 D-loop; other site 266265004390 H-loop/switch region; other site 266265004391 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265004392 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266265004393 conserved cys residue [active] 266265004394 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265004395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265004396 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 266265004397 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265004398 inhibitor-cofactor binding pocket; inhibition site 266265004399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265004400 catalytic residue [active] 266265004401 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 266265004402 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 266265004403 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 266265004404 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 266265004405 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 266265004406 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 266265004407 NAD(P) binding site [chemical binding]; other site 266265004408 catalytic residues [active] 266265004409 succinylarginine dihydrolase; Provisional; Region: PRK13281 266265004410 succinylglutamate desuccinylase; Provisional; Region: PRK05324 266265004411 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 266265004412 active site 266265004413 Zn binding site [ion binding]; other site 266265004414 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 266265004415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265004416 substrate binding pocket [chemical binding]; other site 266265004417 membrane-bound complex binding site; other site 266265004418 hinge residues; other site 266265004419 acetoacetate decarboxylase; Provisional; Region: PRK02265 266265004420 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 266265004421 EAL domain; Region: EAL; pfam00563 266265004422 HDOD domain; Region: HDOD; pfam08668 266265004423 PAS domain; Region: PAS_9; pfam13426 266265004424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265004425 putative active site [active] 266265004426 heme pocket [chemical binding]; other site 266265004427 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265004428 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265004429 metal binding site [ion binding]; metal-binding site 266265004430 active site 266265004431 I-site; other site 266265004432 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265004433 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 266265004434 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265004435 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266265004436 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266265004437 catalytic triad [active] 266265004438 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 266265004439 Protein export membrane protein; Region: SecD_SecF; cl14618 266265004440 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 266265004441 Protein export membrane protein; Region: SecD_SecF; cl14618 266265004442 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265004443 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265004444 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265004445 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265004446 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265004447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266265004448 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266265004449 lipoprotein signal peptidase; Provisional; Region: PRK14776 266265004450 Heavy-metal-associated domain; Region: HMA; pfam00403 266265004451 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265004452 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266265004453 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266265004454 DNA binding residues [nucleotide binding] 266265004455 dimer interface [polypeptide binding]; other site 266265004456 putative metal binding site [ion binding]; other site 266265004457 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 266265004458 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 266265004459 N-terminal domain interface [polypeptide binding]; other site 266265004460 dimer interface [polypeptide binding]; other site 266265004461 substrate binding pocket (H-site) [chemical binding]; other site 266265004462 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266265004463 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265004464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004465 putative substrate translocation pore; other site 266265004466 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265004467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004470 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265004471 putative effector binding pocket; other site 266265004472 dimerization interface [polypeptide binding]; other site 266265004473 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 266265004474 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265004475 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265004476 trimer interface [polypeptide binding]; other site 266265004477 eyelet of channel; other site 266265004478 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265004479 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266265004480 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265004481 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265004482 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265004483 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266265004484 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265004485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004487 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266265004488 putative effector binding pocket; other site 266265004489 putative dimerization interface [polypeptide binding]; other site 266265004490 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 266265004491 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266265004492 putative active site pocket [active] 266265004493 dimerization interface [polypeptide binding]; other site 266265004494 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 266265004495 putative catalytic residue [active] 266265004496 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 266265004497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265004498 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266265004499 putative active site [active] 266265004500 heme pocket [chemical binding]; other site 266265004501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265004502 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265004503 putative active site [active] 266265004504 heme pocket [chemical binding]; other site 266265004505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265004506 dimer interface [polypeptide binding]; other site 266265004507 phosphorylation site [posttranslational modification] 266265004508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265004509 ATP binding site [chemical binding]; other site 266265004510 G-X-G motif; other site 266265004511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265004512 active site 266265004513 phosphorylation site [posttranslational modification] 266265004514 intermolecular recognition site; other site 266265004515 dimerization interface [polypeptide binding]; other site 266265004516 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266265004517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265004518 active site 266265004519 phosphorylation site [posttranslational modification] 266265004520 intermolecular recognition site; other site 266265004521 dimerization interface [polypeptide binding]; other site 266265004522 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265004523 DNA binding residues [nucleotide binding] 266265004524 dimerization interface [polypeptide binding]; other site 266265004525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265004526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265004527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265004528 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266265004529 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265004530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265004531 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266265004532 classical (c) SDRs; Region: SDR_c; cd05233 266265004533 NAD(P) binding site [chemical binding]; other site 266265004534 active site 266265004535 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 266265004536 classical (c) SDRs; Region: SDR_c; cd05233 266265004537 NAD(P) binding site [chemical binding]; other site 266265004538 active site 266265004539 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 266265004540 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 266265004541 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 266265004542 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 266265004543 Phosphoesterase family; Region: Phosphoesterase; pfam04185 266265004544 chromosome condensation membrane protein; Provisional; Region: PRK14196 266265004545 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 266265004546 CHASE3 domain; Region: CHASE3; cl05000 266265004547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265004548 dimer interface [polypeptide binding]; other site 266265004549 phosphorylation site [posttranslational modification] 266265004550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265004551 ATP binding site [chemical binding]; other site 266265004552 Mg2+ binding site [ion binding]; other site 266265004553 G-X-G motif; other site 266265004554 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266265004555 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 266265004556 conserved cys residue [active] 266265004557 Atrophin-1 family; Region: Atrophin-1; pfam03154 266265004558 Predicted transcriptional regulator [Transcription]; Region: COG1959 266265004559 Transcriptional regulator; Region: Rrf2; pfam02082 266265004560 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 266265004561 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266265004562 NAD binding site [chemical binding]; other site 266265004563 substrate binding site [chemical binding]; other site 266265004564 putative active site [active] 266265004565 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266265004566 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 266265004567 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265004568 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265004569 putative DNA binding site [nucleotide binding]; other site 266265004570 putative Zn2+ binding site [ion binding]; other site 266265004571 AsnC family; Region: AsnC_trans_reg; pfam01037 266265004572 haemagglutination activity domain; Region: Haemagg_act; pfam05860 266265004573 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266265004574 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 266265004575 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 266265004576 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 266265004577 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 266265004578 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 266265004579 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 266265004580 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265004581 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 266265004582 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 266265004583 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 266265004584 Family description; Region: UvrD_C_2; pfam13538 266265004585 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 266265004586 AAA domain; Region: AAA_30; pfam13604 266265004587 Family description; Region: UvrD_C_2; pfam13538 266265004588 hypothetical protein; Provisional; Region: PRK09256 266265004589 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 266265004590 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265004591 Uncharacterized conserved protein [Function unknown]; Region: COG1359 266265004592 Uncharacterized conserved protein [Function unknown]; Region: COG1434 266265004593 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 266265004594 putative active site [active] 266265004595 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266265004596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004598 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266265004599 putative dimerization interface [polypeptide binding]; other site 266265004600 aspartate aminotransferase; Provisional; Region: PRK06108 266265004601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265004602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265004603 homodimer interface [polypeptide binding]; other site 266265004604 catalytic residue [active] 266265004605 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 266265004606 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266265004607 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266265004608 RNA binding surface [nucleotide binding]; other site 266265004609 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 266265004610 probable active site [active] 266265004611 ribosome maturation protein RimP; Reviewed; Region: PRK00092 266265004612 Sm and related proteins; Region: Sm_like; cl00259 266265004613 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 266265004614 putative oligomer interface [polypeptide binding]; other site 266265004615 putative RNA binding site [nucleotide binding]; other site 266265004616 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 266265004617 NusA N-terminal domain; Region: NusA_N; pfam08529 266265004618 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 266265004619 RNA binding site [nucleotide binding]; other site 266265004620 homodimer interface [polypeptide binding]; other site 266265004621 NusA-like KH domain; Region: KH_5; pfam13184 266265004622 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 266265004623 G-X-X-G motif; other site 266265004624 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 266265004625 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 266265004626 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 266265004627 translation initiation factor IF-2; Region: IF-2; TIGR00487 266265004628 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 266265004629 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 266265004630 G1 box; other site 266265004631 putative GEF interaction site [polypeptide binding]; other site 266265004632 GTP/Mg2+ binding site [chemical binding]; other site 266265004633 Switch I region; other site 266265004634 G2 box; other site 266265004635 G3 box; other site 266265004636 Switch II region; other site 266265004637 G4 box; other site 266265004638 G5 box; other site 266265004639 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 266265004640 Translation-initiation factor 2; Region: IF-2; pfam11987 266265004641 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 266265004642 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 266265004643 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 266265004644 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 266265004645 RNA binding site [nucleotide binding]; other site 266265004646 active site 266265004647 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 266265004648 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265004649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004650 putative substrate translocation pore; other site 266265004651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004652 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 266265004653 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265004654 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265004655 SPRY domain; Region: SPRY; cl02614 266265004656 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265004657 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265004658 MarR family; Region: MarR; pfam01047 266265004659 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 266265004660 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 266265004661 G1 box; other site 266265004662 putative GEF interaction site [polypeptide binding]; other site 266265004663 GTP/Mg2+ binding site [chemical binding]; other site 266265004664 Switch I region; other site 266265004665 G2 box; other site 266265004666 G3 box; other site 266265004667 Switch II region; other site 266265004668 G4 box; other site 266265004669 G5 box; other site 266265004670 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 266265004671 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 266265004672 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 266265004673 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 266265004674 TPP-binding site [chemical binding]; other site 266265004675 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 266265004676 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 266265004677 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265004678 E3 interaction surface; other site 266265004679 lipoyl attachment site [posttranslational modification]; other site 266265004680 e3 binding domain; Region: E3_binding; pfam02817 266265004681 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266265004682 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 266265004683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265004684 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266265004685 Predicted ATPase [General function prediction only]; Region: COG1485 266265004686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265004687 Walker B; other site 266265004688 D-loop; other site 266265004689 H-loop/switch region; other site 266265004690 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266265004691 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 266265004692 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 266265004693 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 266265004694 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 266265004695 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 266265004696 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266265004697 TadE-like protein; Region: TadE; pfam07811 266265004698 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 266265004699 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266265004700 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 266265004701 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266265004702 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266265004703 AAA domain; Region: AAA_31; pfam13614 266265004704 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 266265004705 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266265004706 ATP binding site [chemical binding]; other site 266265004707 Walker A motif; other site 266265004708 hexamer interface [polypeptide binding]; other site 266265004709 Walker B motif; other site 266265004710 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266265004711 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266265004712 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 266265004713 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266265004714 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 266265004715 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 266265004716 Predicted membrane protein [Function unknown]; Region: COG4655 266265004717 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 266265004718 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 266265004719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265004720 Walker A motif; other site 266265004721 ATP binding site [chemical binding]; other site 266265004722 Walker B motif; other site 266265004723 arginine finger; other site 266265004724 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265004725 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 266265004726 bacterial Hfq-like; Region: Hfq; cd01716 266265004727 hexamer interface [polypeptide binding]; other site 266265004728 Sm1 motif; other site 266265004729 RNA binding site [nucleotide binding]; other site 266265004730 Sm2 motif; other site 266265004731 RNA polymerase sigma factor; Provisional; Region: PRK12511 266265004732 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265004733 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265004734 DNA binding residues [nucleotide binding] 266265004735 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266265004736 Pleckstrin homology-like domain; Region: PH-like; cl17171 266265004737 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 266265004738 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265004739 FAD binding domain; Region: FAD_binding_4; pfam01565 266265004740 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 266265004741 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 266265004742 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265004743 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266265004744 acyl-activating enzyme (AAE) consensus motif; other site 266265004745 putative AMP binding site [chemical binding]; other site 266265004746 putative active site [active] 266265004747 putative CoA binding site [chemical binding]; other site 266265004748 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 266265004749 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265004750 dimer interface [polypeptide binding]; other site 266265004751 active site 266265004752 enoyl-CoA hydratase; Region: PLN02864 266265004753 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266265004754 active site 2 [active] 266265004755 active site 1 [active] 266265004756 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 266265004757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265004758 NAD(P) binding site [chemical binding]; other site 266265004759 active site 266265004760 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 266265004761 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265004762 active site 266265004763 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 266265004764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265004765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265004766 putative sialic acid transporter; Region: 2A0112; TIGR00891 266265004767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004768 putative substrate translocation pore; other site 266265004769 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 266265004770 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266265004771 putative ion selectivity filter; other site 266265004772 putative pore gating glutamate residue; other site 266265004773 acetyl-CoA synthetase; Provisional; Region: PRK00174 266265004774 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265004775 acyl-activating enzyme (AAE) consensus motif; other site 266265004776 AMP binding site [chemical binding]; other site 266265004777 active site 266265004778 CoA binding site [chemical binding]; other site 266265004779 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265004780 Long chain acyl-CoA dehydrogenase; Region: LCAD; cd01160 266265004781 FAD binding site [chemical binding]; other site 266265004782 substrate binding pocket [chemical binding]; other site 266265004783 catalytic base [active] 266265004784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265004785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265004786 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265004787 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265004788 enoyl-CoA hydratase; Provisional; Region: PRK07657 266265004789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265004790 substrate binding site [chemical binding]; other site 266265004791 oxyanion hole (OAH) forming residues; other site 266265004792 trimer interface [polypeptide binding]; other site 266265004793 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265004794 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 266265004795 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 266265004796 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265004797 active site 266265004798 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 266265004799 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266265004800 DUF35 OB-fold domain; Region: DUF35; pfam01796 266265004801 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266265004802 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266265004803 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266265004804 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266265004805 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266265004806 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266265004807 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 266265004808 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266265004809 carboxyltransferase (CT) interaction site; other site 266265004810 biotinylation site [posttranslational modification]; other site 266265004811 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266265004812 putative active site [active] 266265004813 putative catalytic site [active] 266265004814 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266265004815 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 266265004816 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265004817 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 266265004818 acyl-activating enzyme (AAE) consensus motif; other site 266265004819 putative AMP binding site [chemical binding]; other site 266265004820 putative active site [active] 266265004821 putative CoA binding site [chemical binding]; other site 266265004822 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265004823 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265004824 Walker A/P-loop; other site 266265004825 ATP binding site [chemical binding]; other site 266265004826 Q-loop/lid; other site 266265004827 ABC transporter signature motif; other site 266265004828 Walker B; other site 266265004829 D-loop; other site 266265004830 H-loop/switch region; other site 266265004831 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265004832 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265004833 Walker A/P-loop; other site 266265004834 ATP binding site [chemical binding]; other site 266265004835 Q-loop/lid; other site 266265004836 ABC transporter signature motif; other site 266265004837 Walker B; other site 266265004838 D-loop; other site 266265004839 H-loop/switch region; other site 266265004840 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265004841 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265004842 TM-ABC transporter signature motif; other site 266265004843 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265004844 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265004845 TM-ABC transporter signature motif; other site 266265004846 Coenzyme A transferase; Region: CoA_trans; cl17247 266265004847 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 266265004848 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265004849 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 266265004850 putative ligand binding site [chemical binding]; other site 266265004851 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265004852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265004853 substrate binding site [chemical binding]; other site 266265004854 oxyanion hole (OAH) forming residues; other site 266265004855 trimer interface [polypeptide binding]; other site 266265004856 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265004857 classical (c) SDRs; Region: SDR_c; cd05233 266265004858 NAD(P) binding site [chemical binding]; other site 266265004859 active site 266265004860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265004861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265004862 AMP-binding domain protein; Validated; Region: PRK08315 266265004863 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265004864 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 266265004865 acyl-activating enzyme (AAE) consensus motif; other site 266265004866 acyl-activating enzyme (AAE) consensus motif; other site 266265004867 putative AMP binding site [chemical binding]; other site 266265004868 putative active site [active] 266265004869 putative CoA binding site [chemical binding]; other site 266265004870 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266265004871 DUF35 OB-fold domain; Region: DUF35; pfam01796 266265004872 thiolase; Provisional; Region: PRK06158 266265004873 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265004874 active site 266265004875 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-1; cd12808 266265004876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265004877 catalytic site [active] 266265004878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265004879 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265004880 substrate binding site [chemical binding]; other site 266265004881 oxyanion hole (OAH) forming residues; other site 266265004882 trimer interface [polypeptide binding]; other site 266265004883 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266265004884 active site 266265004885 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265004886 MarR family; Region: MarR_2; pfam12802 266265004887 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265004888 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265004889 trimer interface [polypeptide binding]; other site 266265004890 eyelet of channel; other site 266265004891 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 266265004892 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 266265004893 Na binding site [ion binding]; other site 266265004894 Protein of unknown function, DUF485; Region: DUF485; pfam04341 266265004895 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 266265004896 putative transposase OrfB; Reviewed; Region: PHA02517 266265004897 HTH-like domain; Region: HTH_21; pfam13276 266265004898 Integrase core domain; Region: rve; pfam00665 266265004899 Integrase core domain; Region: rve_3; pfam13683 266265004900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265004901 Transposase; Region: HTH_Tnp_1; pfam01527 266265004902 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265004903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004904 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266265004905 putative dimerization interface [polypeptide binding]; other site 266265004906 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266265004907 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266265004908 substrate binding site [chemical binding]; other site 266265004909 ligand binding site [chemical binding]; other site 266265004910 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266265004911 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266265004912 substrate binding site [chemical binding]; other site 266265004913 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265004914 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265004915 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 266265004916 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 266265004917 active site 266265004918 catalytic residues [active] 266265004919 metal binding site [ion binding]; metal-binding site 266265004920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265004921 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265004922 DNA binding residues [nucleotide binding] 266265004923 dimerization interface [polypeptide binding]; other site 266265004924 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 266265004925 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265004926 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 266265004927 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 266265004928 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 266265004929 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265004930 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266265004931 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266265004932 C-terminal domain interface [polypeptide binding]; other site 266265004933 GSH binding site (G-site) [chemical binding]; other site 266265004934 putative dimer interface [polypeptide binding]; other site 266265004935 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266265004936 dimer interface [polypeptide binding]; other site 266265004937 N-terminal domain interface [polypeptide binding]; other site 266265004938 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266265004939 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 266265004940 active site 266265004941 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265004942 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266265004943 NAD(P) binding site [chemical binding]; other site 266265004944 catalytic residues [active] 266265004945 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265004946 classical (c) SDRs; Region: SDR_c; cd05233 266265004947 NAD(P) binding site [chemical binding]; other site 266265004948 active site 266265004949 benzoate transport; Region: 2A0115; TIGR00895 266265004950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265004951 putative substrate translocation pore; other site 266265004952 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265004953 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265004954 trimer interface [polypeptide binding]; other site 266265004955 eyelet of channel; other site 266265004956 Helix-turn-helix domain; Region: HTH_17; pfam12728 266265004957 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 266265004958 Citrate synthase; Region: Citrate_synt; pfam00285 266265004959 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 266265004960 dimer interface [polypeptide binding]; other site 266265004961 active site 266265004962 oxalacetate/citrate binding site [chemical binding]; other site 266265004963 citrylCoA binding site [chemical binding]; other site 266265004964 coenzyme A binding site [chemical binding]; other site 266265004965 catalytic triad [active] 266265004966 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266265004967 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266265004968 catalytic residues [active] 266265004969 catalytic nucleophile [active] 266265004970 Recombinase; Region: Recombinase; pfam07508 266265004971 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266265004972 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265004973 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265004974 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265004975 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266265004976 homotrimer interaction site [polypeptide binding]; other site 266265004977 putative active site [active] 266265004978 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265004979 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 266265004980 dimer interface [polypeptide binding]; other site 266265004981 putative metal binding site [ion binding]; other site 266265004982 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265004983 AsnC family; Region: AsnC_trans_reg; pfam01037 266265004984 transposase; Validated; Region: PRK08181 266265004985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265004986 Walker A motif; other site 266265004987 ATP binding site [chemical binding]; other site 266265004988 Walker B motif; other site 266265004989 arginine finger; other site 266265004990 Integrase core domain; Region: rve; pfam00665 266265004991 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265004992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265004993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265004994 oxidoreductase; Provisional; Region: PRK06196 266265004995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265004996 NAD(P) binding site [chemical binding]; other site 266265004997 active site 266265004998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265004999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265005000 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265005001 putative effector binding pocket; other site 266265005002 dimerization interface [polypeptide binding]; other site 266265005003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265005004 NmrA-like family; Region: NmrA; pfam05368 266265005005 NAD(P) binding site [chemical binding]; other site 266265005006 active site 266265005007 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266265005008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265005009 short chain dehydrogenase; Provisional; Region: PRK06197 266265005010 NAD(P) binding site [chemical binding]; other site 266265005011 active site 266265005012 short chain dehydrogenase; Validated; Region: PRK08264 266265005013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265005014 NAD(P) binding site [chemical binding]; other site 266265005015 active site 266265005016 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266265005017 active site 1 [active] 266265005018 dimer interface [polypeptide binding]; other site 266265005019 hexamer interface [polypeptide binding]; other site 266265005020 active site 2 [active] 266265005021 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265005022 NADP binding site [chemical binding]; other site 266265005023 active site 266265005024 steroid binding site; other site 266265005025 short chain dehydrogenase; Provisional; Region: PRK12937 266265005026 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 266265005027 NADP binding site [chemical binding]; other site 266265005028 homodimer interface [polypeptide binding]; other site 266265005029 active site 266265005030 substrate binding site [chemical binding]; other site 266265005031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265005032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265005033 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266265005034 putative effector binding pocket; other site 266265005035 putative dimerization interface [polypeptide binding]; other site 266265005036 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265005037 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265005038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265005039 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 266265005040 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 266265005041 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 266265005042 NAD(P) binding pocket [chemical binding]; other site 266265005043 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266265005044 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 266265005045 Major royal jelly protein; Region: MRJP; pfam03022 266265005046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265005047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265005048 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265005049 putative effector binding pocket; other site 266265005050 dimerization interface [polypeptide binding]; other site 266265005051 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 266265005052 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 266265005053 putative NAD(P) binding site [chemical binding]; other site 266265005054 dimer interface [polypeptide binding]; other site 266265005055 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 266265005056 dimer interface [polypeptide binding]; other site 266265005057 FMN binding site [chemical binding]; other site 266265005058 Uncharacterized conserved protein [Function unknown]; Region: COG1359 266265005059 LrgA family; Region: LrgA; pfam03788 266265005060 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 266265005061 EthD domain; Region: EthD; pfam07110 266265005062 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266265005063 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266265005064 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 266265005065 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266265005066 NADP binding site [chemical binding]; other site 266265005067 substrate binding site [chemical binding]; other site 266265005068 active site 266265005069 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 266265005070 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266265005071 putative ligand binding site [chemical binding]; other site 266265005072 putative NAD binding site [chemical binding]; other site 266265005073 catalytic site [active] 266265005074 short chain dehydrogenase; Provisional; Region: PRK06180 266265005075 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265005076 NADP binding site [chemical binding]; other site 266265005077 active site 266265005078 steroid binding site; other site 266265005079 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 266265005080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265005081 YCII-related domain; Region: YCII; cl00999 266265005082 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 266265005083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265005084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265005085 dimerization interface [polypeptide binding]; other site 266265005086 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266265005087 Na binding site [ion binding]; other site 266265005088 Integrase core domain; Region: rve; pfam00665 266265005089 transposase; Validated; Region: PRK08181 266265005090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265005091 Walker A motif; other site 266265005092 ATP binding site [chemical binding]; other site 266265005093 ACT domain; Region: ACT_3; pfam10000 266265005094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 266265005095 Family description; Region: ACT_7; pfam13840 266265005096 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 266265005097 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 266265005098 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 266265005099 putative active site [active] 266265005100 putative NTP binding site [chemical binding]; other site 266265005101 putative nucleic acid binding site [nucleotide binding]; other site 266265005102 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 266265005103 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265005104 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265005105 catalytic residue [active] 266265005106 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266265005107 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 266265005108 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266265005109 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 266265005110 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 266265005111 Type IV secretion system proteins; Region: T4SS; pfam07996 266265005112 VirB8 protein; Region: VirB8; pfam04335 266265005113 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266265005114 VirB7 interaction site; other site 266265005115 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 266265005116 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266265005117 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266265005118 Walker A motif; other site 266265005119 hexamer interface [polypeptide binding]; other site 266265005120 ATP binding site [chemical binding]; other site 266265005121 Walker B motif; other site 266265005122 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266265005123 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 266265005124 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265005125 Walker A motif; other site 266265005126 ATP binding site [chemical binding]; other site 266265005127 Walker B motif; other site 266265005128 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 266265005129 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266265005130 SprT homologues; Region: SprT; cl01182 266265005131 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 266265005132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265005133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265005134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266265005135 Integrase core domain; Region: rve; pfam00665 266265005136 Integrase core domain; Region: rve_3; pfam13683 266265005137 Transposase; Region: HTH_Tnp_1; pfam01527 266265005138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265005139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265005140 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265005141 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265005142 trimer interface [polypeptide binding]; other site 266265005143 eyelet of channel; other site 266265005144 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266265005145 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266265005146 C-terminal domain interface [polypeptide binding]; other site 266265005147 GSH binding site (G-site) [chemical binding]; other site 266265005148 putative dimer interface [polypeptide binding]; other site 266265005149 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266265005150 dimer interface [polypeptide binding]; other site 266265005151 N-terminal domain interface [polypeptide binding]; other site 266265005152 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266265005153 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265005154 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265005155 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 266265005156 Cupin domain; Region: Cupin_2; pfam07883 266265005157 Cupin domain; Region: Cupin_2; cl17218 266265005158 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266265005159 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266265005160 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266265005161 active site 266265005162 benzoate transport; Region: 2A0115; TIGR00895 266265005163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265005164 putative substrate translocation pore; other site 266265005165 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265005166 MarR family; Region: MarR; pfam01047 266265005167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265005168 putative active site [active] 266265005169 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 266265005170 heme pocket [chemical binding]; other site 266265005171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265005172 putative active site [active] 266265005173 heme pocket [chemical binding]; other site 266265005174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265005175 dimer interface [polypeptide binding]; other site 266265005176 phosphorylation site [posttranslational modification] 266265005177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265005178 ATP binding site [chemical binding]; other site 266265005179 Mg2+ binding site [ion binding]; other site 266265005180 G-X-G motif; other site 266265005181 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265005182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265005183 active site 266265005184 phosphorylation site [posttranslational modification] 266265005185 intermolecular recognition site; other site 266265005186 dimerization interface [polypeptide binding]; other site 266265005187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265005188 Response regulator receiver domain; Region: Response_reg; pfam00072 266265005189 active site 266265005190 phosphorylation site [posttranslational modification] 266265005191 intermolecular recognition site; other site 266265005192 dimerization interface [polypeptide binding]; other site 266265005193 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005194 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005195 putative dimer interface [polypeptide binding]; other site 266265005196 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005197 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005198 putative dimer interface [polypeptide binding]; other site 266265005199 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266265005200 oligomerisation interface [polypeptide binding]; other site 266265005201 mobile loop; other site 266265005202 roof hairpin; other site 266265005203 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266265005204 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266265005205 ring oligomerisation interface [polypeptide binding]; other site 266265005206 ATP/Mg binding site [chemical binding]; other site 266265005207 stacking interactions; other site 266265005208 hinge regions; other site 266265005209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265005210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266265005211 dimer interface [polypeptide binding]; other site 266265005212 phosphorylation site [posttranslational modification] 266265005213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265005214 Mg2+ binding site [ion binding]; other site 266265005215 G-X-G motif; other site 266265005216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265005217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265005218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266265005219 Integrase core domain; Region: rve; pfam00665 266265005220 Integrase core domain; Region: rve_3; pfam13683 266265005221 Transposase; Region: HTH_Tnp_1; pfam01527 266265005222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265005223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265005224 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265005225 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265005226 trimer interface [polypeptide binding]; other site 266265005227 eyelet of channel; other site 266265005228 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 266265005229 maleylacetoacetate isomerase; Region: maiA; TIGR01262 266265005230 C-terminal domain interface [polypeptide binding]; other site 266265005231 GSH binding site (G-site) [chemical binding]; other site 266265005232 putative dimer interface [polypeptide binding]; other site 266265005233 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 266265005234 dimer interface [polypeptide binding]; other site 266265005235 N-terminal domain interface [polypeptide binding]; other site 266265005236 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 266265005237 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265005238 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265005239 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 266265005240 Cupin domain; Region: Cupin_2; pfam07883 266265005241 Cupin domain; Region: Cupin_2; cl17218 266265005242 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266265005243 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266265005244 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266265005245 active site 266265005246 benzoate transport; Region: 2A0115; TIGR00895 266265005247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265005248 putative substrate translocation pore; other site 266265005249 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265005250 MarR family; Region: MarR; pfam01047 266265005251 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265005252 putative active site [active] 266265005253 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 266265005254 heme pocket [chemical binding]; other site 266265005255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265005256 putative active site [active] 266265005257 heme pocket [chemical binding]; other site 266265005258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265005259 dimer interface [polypeptide binding]; other site 266265005260 phosphorylation site [posttranslational modification] 266265005261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265005262 ATP binding site [chemical binding]; other site 266265005263 Mg2+ binding site [ion binding]; other site 266265005264 G-X-G motif; other site 266265005265 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265005266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265005267 active site 266265005268 phosphorylation site [posttranslational modification] 266265005269 intermolecular recognition site; other site 266265005270 dimerization interface [polypeptide binding]; other site 266265005271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265005272 Response regulator receiver domain; Region: Response_reg; pfam00072 266265005273 active site 266265005274 phosphorylation site [posttranslational modification] 266265005275 intermolecular recognition site; other site 266265005276 dimerization interface [polypeptide binding]; other site 266265005277 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005278 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005279 putative dimer interface [polypeptide binding]; other site 266265005280 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005281 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005282 putative dimer interface [polypeptide binding]; other site 266265005283 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266265005284 oligomerisation interface [polypeptide binding]; other site 266265005285 mobile loop; other site 266265005286 roof hairpin; other site 266265005287 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266265005288 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266265005289 ring oligomerisation interface [polypeptide binding]; other site 266265005290 ATP/Mg binding site [chemical binding]; other site 266265005291 stacking interactions; other site 266265005292 hinge regions; other site 266265005293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265005294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266265005295 dimer interface [polypeptide binding]; other site 266265005296 phosphorylation site [posttranslational modification] 266265005297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265005298 Mg2+ binding site [ion binding]; other site 266265005299 G-X-G motif; other site 266265005300 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005301 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005302 putative dimer interface [polypeptide binding]; other site 266265005303 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005304 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005305 putative dimer interface [polypeptide binding]; other site 266265005306 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005307 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005308 putative dimer interface [polypeptide binding]; other site 266265005309 Ferredoxin [Energy production and conversion]; Region: COG1146 266265005310 4Fe-4S binding domain; Region: Fer4; cl02805 266265005311 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 266265005312 CsbD-like; Region: CsbD; pfam05532 266265005313 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266265005314 DNA-binding site [nucleotide binding]; DNA binding site 266265005315 RNA-binding motif; other site 266265005316 H-NS histone family; Region: Histone_HNS; pfam00816 266265005317 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266265005318 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 266265005319 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265005320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265005321 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265005322 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265005323 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265005324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265005325 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265005326 Transposase; Region: HTH_Tnp_1; pfam01527 266265005327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265005328 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 266265005329 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 266265005330 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265005331 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265005332 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005333 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005334 putative dimer interface [polypeptide binding]; other site 266265005335 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005336 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005337 putative dimer interface [polypeptide binding]; other site 266265005338 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265005339 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265005340 putative dimer interface [polypeptide binding]; other site 266265005341 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 266265005342 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 266265005343 ParB-like nuclease domain; Region: ParBc; pfam02195 266265005344 Domain of unknown function (DUF932); Region: DUF932; pfam06067 266265005345 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 266265005346 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 266265005347 5' RNA guide strand anchoring site; other site 266265005348 active site 266265005349 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266265005350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265005351 non-specific DNA binding site [nucleotide binding]; other site 266265005352 salt bridge; other site 266265005353 sequence-specific DNA binding site [nucleotide binding]; other site 266265005354 Domain of unknown function (DUF955); Region: DUF955; pfam06114 266265005355 thymidylate synthase, methanogen type; Region: thy_syn_methano; TIGR03283 266265005356 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 266265005357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265005358 AAA domain; Region: AAA_21; pfam13304 266265005359 Walker A/P-loop; other site 266265005360 ATP binding site [chemical binding]; other site 266265005361 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 266265005362 putative active site [active] 266265005363 putative metal-binding site [ion binding]; other site 266265005364 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 266265005365 Part of AAA domain; Region: AAA_19; pfam13245 266265005366 Integrase core domain; Region: rve; pfam00665 266265005367 transposase; Validated; Region: PRK08181 266265005368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265005369 Walker A motif; other site 266265005370 ATP binding site [chemical binding]; other site 266265005371 Walker B motif; other site 266265005372 arginine finger; other site 266265005373 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265005374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266265005375 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265005376 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265005377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265005378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265005379 Transposase; Region: HTH_Tnp_1; pfam01527 266265005380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265005381 Transposase; Region: HTH_Tnp_1; cl17663 266265005382 putative transposase OrfB; Reviewed; Region: PHA02517 266265005383 HTH-like domain; Region: HTH_21; pfam13276 266265005384 Integrase core domain; Region: rve; pfam00665 266265005385 Integrase core domain; Region: rve_3; pfam13683 266265005386 putative transposase OrfB; Reviewed; Region: PHA02517 266265005387 HTH-like domain; Region: HTH_21; pfam13276 266265005388 Integrase core domain; Region: rve; pfam00665 266265005389 Integrase core domain; Region: rve_3; pfam13683 266265005390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265005391 Transposase; Region: HTH_Tnp_1; pfam01527 266265005392 integrase; Provisional; Region: PRK09692 266265005393 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266265005394 active site 266265005395 Int/Topo IB signature motif; other site 266265005396 ribonuclease R; Region: RNase_R; TIGR02063 266265005397 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 266265005398 RNB domain; Region: RNB; pfam00773 266265005399 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 266265005400 RNA binding site [nucleotide binding]; other site 266265005401 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 266265005402 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 266265005403 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266265005404 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 266265005405 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266265005406 active site 266265005407 dimer interface [polypeptide binding]; other site 266265005408 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265005409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265005410 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265005411 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 266265005412 putative ADP-binding pocket [chemical binding]; other site 266265005413 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 266265005414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265005415 non-specific DNA binding site [nucleotide binding]; other site 266265005416 salt bridge; other site 266265005417 sequence-specific DNA binding site [nucleotide binding]; other site 266265005418 tyrosine kinase; Provisional; Region: PRK11519 266265005419 Chain length determinant protein; Region: Wzz; pfam02706 266265005420 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266265005421 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 266265005422 Nucleotide binding site [chemical binding]; other site 266265005423 DTAP/Switch II; other site 266265005424 Switch I; other site 266265005425 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 266265005426 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 266265005427 active site 266265005428 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266265005429 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266265005430 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265005431 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 266265005432 ligand binding site [chemical binding]; other site 266265005433 flexible hinge region; other site 266265005434 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266265005435 non-specific DNA interactions [nucleotide binding]; other site 266265005436 DNA binding site [nucleotide binding] 266265005437 sequence specific DNA binding site [nucleotide binding]; other site 266265005438 putative cAMP binding site [chemical binding]; other site 266265005439 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 266265005440 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 266265005441 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 266265005442 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 266265005443 motif 1; other site 266265005444 dimer interface [polypeptide binding]; other site 266265005445 active site 266265005446 motif 2; other site 266265005447 motif 3; other site 266265005448 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265005449 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266265005450 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265005451 acyl carrier protein; Provisional; Region: PRK07081 266265005452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266265005453 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265005454 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 266265005455 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265005456 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265005457 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 266265005458 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265005459 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 266265005460 putative ADP-binding pocket [chemical binding]; other site 266265005461 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266265005462 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 266265005463 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266265005464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266265005465 active site 266265005466 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265005467 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265005468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265005469 S-adenosylmethionine binding site [chemical binding]; other site 266265005470 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266265005471 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 266265005472 Substrate binding site; other site 266265005473 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 266265005474 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266265005475 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265005476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265005477 DNA-binding site [nucleotide binding]; DNA binding site 266265005478 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266265005479 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266265005480 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266265005481 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 266265005482 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266265005483 Catalytic site [active] 266265005484 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266265005485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265005486 dimer interface [polypeptide binding]; other site 266265005487 conserved gate region; other site 266265005488 putative PBP binding loops; other site 266265005489 ABC-ATPase subunit interface; other site 266265005490 cystine transporter subunit; Provisional; Region: PRK11260 266265005491 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265005492 substrate binding pocket [chemical binding]; other site 266265005493 membrane-bound complex binding site; other site 266265005494 hinge residues; other site 266265005495 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 266265005496 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 266265005497 quinone interaction residues [chemical binding]; other site 266265005498 active site 266265005499 catalytic residues [active] 266265005500 FMN binding site [chemical binding]; other site 266265005501 substrate binding site [chemical binding]; other site 266265005502 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 266265005503 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 266265005504 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 266265005505 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 266265005506 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 266265005507 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 266265005508 nudix motif; other site 266265005509 hypothetical protein; Provisional; Region: PRK02487 266265005510 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 266265005511 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266265005512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265005513 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265005514 NAD(P) binding site [chemical binding]; other site 266265005515 active site 266265005516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265005517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265005518 WHG domain; Region: WHG; pfam13305 266265005519 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 266265005520 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265005521 substrate binding site [chemical binding]; other site 266265005522 oxyanion hole (OAH) forming residues; other site 266265005523 trimer interface [polypeptide binding]; other site 266265005524 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 266265005525 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 266265005526 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266265005527 active site 266265005528 dimer interface [polypeptide binding]; other site 266265005529 non-prolyl cis peptide bond; other site 266265005530 insertion regions; other site 266265005531 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265005532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265005533 dimer interface [polypeptide binding]; other site 266265005534 conserved gate region; other site 266265005535 putative PBP binding loops; other site 266265005536 ABC-ATPase subunit interface; other site 266265005537 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265005538 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 266265005539 Walker A/P-loop; other site 266265005540 ATP binding site [chemical binding]; other site 266265005541 Q-loop/lid; other site 266265005542 ABC transporter signature motif; other site 266265005543 Walker B; other site 266265005544 D-loop; other site 266265005545 H-loop/switch region; other site 266265005546 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 266265005547 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 266265005548 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266265005549 FMN binding site [chemical binding]; other site 266265005550 active site 266265005551 catalytic residues [active] 266265005552 substrate binding site [chemical binding]; other site 266265005553 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265005554 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266265005555 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266265005556 TPR repeat; Region: TPR_11; pfam13414 266265005557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265005558 binding surface 266265005559 TPR motif; other site 266265005560 TPR repeat; Region: TPR_11; pfam13414 266265005561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265005562 binding surface 266265005563 TPR motif; other site 266265005564 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 266265005565 AAA domain; Region: AAA_33; pfam13671 266265005566 ligand-binding site [chemical binding]; other site 266265005567 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 266265005568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265005569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265005570 active site 266265005571 catalytic tetrad [active] 266265005572 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266265005573 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266265005574 nodulation ABC transporter NodI; Provisional; Region: PRK13537 266265005575 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 266265005576 Walker A/P-loop; other site 266265005577 ATP binding site [chemical binding]; other site 266265005578 Q-loop/lid; other site 266265005579 ABC transporter signature motif; other site 266265005580 Walker B; other site 266265005581 D-loop; other site 266265005582 H-loop/switch region; other site 266265005583 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265005584 Ligand Binding Site [chemical binding]; other site 266265005585 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 266265005586 LexA repressor; Validated; Region: PRK00215 266265005587 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 266265005588 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 266265005589 Catalytic site [active] 266265005590 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266265005591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265005592 substrate binding pocket [chemical binding]; other site 266265005593 membrane-bound complex binding site; other site 266265005594 hinge residues; other site 266265005595 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266265005596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265005597 dimer interface [polypeptide binding]; other site 266265005598 conserved gate region; other site 266265005599 putative PBP binding loops; other site 266265005600 ABC-ATPase subunit interface; other site 266265005601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265005602 dimer interface [polypeptide binding]; other site 266265005603 conserved gate region; other site 266265005604 putative PBP binding loops; other site 266265005605 ABC-ATPase subunit interface; other site 266265005606 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 266265005607 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 266265005608 Walker A/P-loop; other site 266265005609 ATP binding site [chemical binding]; other site 266265005610 Q-loop/lid; other site 266265005611 ABC transporter signature motif; other site 266265005612 Walker B; other site 266265005613 D-loop; other site 266265005614 H-loop/switch region; other site 266265005615 TOBE-like domain; Region: TOBE_3; pfam12857 266265005616 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 266265005617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265005618 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 266265005619 substrate binding site [chemical binding]; other site 266265005620 dimerization interface [polypeptide binding]; other site 266265005621 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266265005622 active site 266265005623 homodimer interface [polypeptide binding]; other site 266265005624 homotetramer interface [polypeptide binding]; other site 266265005625 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 266265005626 tartronate semialdehyde reductase; Provisional; Region: PRK15059 266265005627 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265005628 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 266265005629 glyoxylate carboligase; Provisional; Region: PRK11269 266265005630 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265005631 PYR/PP interface [polypeptide binding]; other site 266265005632 dimer interface [polypeptide binding]; other site 266265005633 TPP binding site [chemical binding]; other site 266265005634 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265005635 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 266265005636 TPP-binding site [chemical binding]; other site 266265005637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265005638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265005639 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265005640 putative effector binding pocket; other site 266265005641 dimerization interface [polypeptide binding]; other site 266265005642 RNA polymerase sigma factor; Provisional; Region: PRK12533 266265005643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265005644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265005645 DNA binding residues [nucleotide binding] 266265005646 Putative zinc-finger; Region: zf-HC2; pfam13490 266265005647 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266265005648 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 266265005649 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 266265005650 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 266265005651 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 266265005652 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 266265005653 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 266265005654 replicative DNA helicase; Provisional; Region: PRK07004 266265005655 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 266265005656 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 266265005657 Walker A motif; other site 266265005658 ATP binding site [chemical binding]; other site 266265005659 Walker B motif; other site 266265005660 DNA binding loops [nucleotide binding] 266265005661 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266265005662 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266265005663 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266265005664 active site 266265005665 catalytic residues [active] 266265005666 DNA binding site [nucleotide binding] 266265005667 Int/Topo IB signature motif; other site 266265005668 Transposase; Region: HTH_Tnp_1; pfam01527 266265005669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265005670 HTH-like domain; Region: HTH_21; pfam13276 266265005671 Integrase core domain; Region: rve; pfam00665 266265005672 Integrase core domain; Region: rve; pfam00665 266265005673 transposase; Validated; Region: PRK08181 266265005674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265005675 Walker A motif; other site 266265005676 ATP binding site [chemical binding]; other site 266265005677 Walker B motif; other site 266265005678 arginine finger; other site 266265005679 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266265005680 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266265005681 catalytic residues [active] 266265005682 catalytic nucleophile [active] 266265005683 Presynaptic Site I dimer interface [polypeptide binding]; other site 266265005684 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266265005685 Synaptic Flat tetramer interface [polypeptide binding]; other site 266265005686 Synaptic Site I dimer interface [polypeptide binding]; other site 266265005687 DNA binding site [nucleotide binding] 266265005688 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 266265005689 AAA domain; Region: AAA_21; pfam13304 266265005690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265005691 ABC transporter signature motif; other site 266265005692 Walker B; other site 266265005693 D-loop; other site 266265005694 H-loop/switch region; other site 266265005695 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266265005696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265005697 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266265005698 putative dimerization interface [polypeptide binding]; other site 266265005699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265005700 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265005701 substrate binding pocket [chemical binding]; other site 266265005702 membrane-bound complex binding site; other site 266265005703 hinge residues; other site 266265005704 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265005705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265005706 dimer interface [polypeptide binding]; other site 266265005707 conserved gate region; other site 266265005708 putative PBP binding loops; other site 266265005709 ABC-ATPase subunit interface; other site 266265005710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265005711 dimer interface [polypeptide binding]; other site 266265005712 conserved gate region; other site 266265005713 putative PBP binding loops; other site 266265005714 ABC-ATPase subunit interface; other site 266265005715 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265005716 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265005717 Walker A/P-loop; other site 266265005718 ATP binding site [chemical binding]; other site 266265005719 Q-loop/lid; other site 266265005720 ABC transporter signature motif; other site 266265005721 Walker B; other site 266265005722 D-loop; other site 266265005723 H-loop/switch region; other site 266265005724 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266265005725 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 266265005726 ligand binding site [chemical binding]; other site 266265005727 NAD binding site [chemical binding]; other site 266265005728 catalytic site [active] 266265005729 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 266265005730 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266265005731 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 266265005732 phosphate binding site [ion binding]; other site 266265005733 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266265005734 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 266265005735 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265005736 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 266265005737 C-terminal domain interface [polypeptide binding]; other site 266265005738 GSH binding site (G-site) [chemical binding]; other site 266265005739 dimer interface [polypeptide binding]; other site 266265005740 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 266265005741 dimer interface [polypeptide binding]; other site 266265005742 N-terminal domain interface [polypeptide binding]; other site 266265005743 substrate binding pocket (H-site) [chemical binding]; other site 266265005744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265005745 Transposase; Region: HTH_Tnp_1; pfam01527 266265005746 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265005747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265005748 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265005749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265005750 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265005751 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265005752 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265005753 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 266265005754 trimer interface [polypeptide binding]; other site 266265005755 active site 266265005756 substrate binding site [chemical binding]; other site 266265005757 CoA binding site [chemical binding]; other site 266265005758 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265005759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265005760 non-specific DNA binding site [nucleotide binding]; other site 266265005761 salt bridge; other site 266265005762 sequence-specific DNA binding site [nucleotide binding]; other site 266265005763 PAS domain; Region: PAS_9; pfam13426 266265005764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265005765 putative active site [active] 266265005766 heme pocket [chemical binding]; other site 266265005767 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265005768 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265005769 dimer interface [polypeptide binding]; other site 266265005770 putative CheW interface [polypeptide binding]; other site 266265005771 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266265005772 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265005773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265005774 sequence-specific DNA binding site [nucleotide binding]; other site 266265005775 salt bridge; other site 266265005776 Replication initiation factor; Region: Rep_trans; pfam02486 266265005777 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 266265005778 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 266265005779 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 266265005780 short chain dehydrogenase; Provisional; Region: PRK06125 266265005781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265005782 NAD(P) binding site [chemical binding]; other site 266265005783 active site 266265005784 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266265005785 NlpC/P60 family; Region: NLPC_P60; pfam00877 266265005786 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 266265005787 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 266265005788 putative active site [active] 266265005789 PhoH-like protein; Region: PhoH; pfam02562 266265005790 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 266265005791 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266265005792 catalytic triad [active] 266265005793 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 266265005794 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 266265005795 putative active site [active] 266265005796 putative catalytic site [active] 266265005797 putative Zn binding site [ion binding]; other site 266265005798 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 266265005799 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 266265005800 NAD binding site [chemical binding]; other site 266265005801 substrate binding site [chemical binding]; other site 266265005802 active site 266265005803 putative formyltransferase; Provisional; Region: PRK06988 266265005804 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 266265005805 active site 266265005806 substrate binding site [chemical binding]; other site 266265005807 cosubstrate binding site; other site 266265005808 catalytic site [active] 266265005809 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 266265005810 active site 266265005811 hexamer interface [polypeptide binding]; other site 266265005812 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 266265005813 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 266265005814 Ligand binding site; other site 266265005815 Putative Catalytic site; other site 266265005816 DXD motif; other site 266265005817 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 266265005818 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266265005819 inhibitor-cofactor binding pocket; inhibition site 266265005820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265005821 catalytic residue [active] 266265005822 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 266265005823 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266265005824 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266265005825 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 266265005826 aminotransferase AlaT; Validated; Region: PRK09265 266265005827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265005828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265005829 homodimer interface [polypeptide binding]; other site 266265005830 catalytic residue [active] 266265005831 homoserine dehydrogenase; Provisional; Region: PRK06349 266265005832 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266265005833 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 266265005834 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 266265005835 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 266265005836 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 266265005837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265005838 catalytic residue [active] 266265005839 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266265005840 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266265005841 dimer interface [polypeptide binding]; other site 266265005842 putative functional site; other site 266265005843 putative MPT binding site; other site 266265005844 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 266265005845 MoaE interaction surface [polypeptide binding]; other site 266265005846 MoeB interaction surface [polypeptide binding]; other site 266265005847 thiocarboxylated glycine; other site 266265005848 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 266265005849 MoaE homodimer interface [polypeptide binding]; other site 266265005850 MoaD interaction [polypeptide binding]; other site 266265005851 active site residues [active] 266265005852 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 266265005853 apolar tunnel; other site 266265005854 heme binding site [chemical binding]; other site 266265005855 dimerization interface [polypeptide binding]; other site 266265005856 Transcriptional regulator; Region: Rrf2; cl17282 266265005857 Rrf2 family protein; Region: rrf2_super; TIGR00738 266265005858 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 266265005859 Clp amino terminal domain; Region: Clp_N; pfam02861 266265005860 Clp amino terminal domain; Region: Clp_N; pfam02861 266265005861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265005862 Walker A motif; other site 266265005863 ATP binding site [chemical binding]; other site 266265005864 Walker B motif; other site 266265005865 arginine finger; other site 266265005866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265005867 Walker A motif; other site 266265005868 ATP binding site [chemical binding]; other site 266265005869 Walker B motif; other site 266265005870 arginine finger; other site 266265005871 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266265005872 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 266265005873 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 266265005874 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 266265005875 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266265005876 DNA binding residues [nucleotide binding] 266265005877 putative dimer interface [polypeptide binding]; other site 266265005878 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266265005879 multidrug efflux protein; Reviewed; Region: PRK01766 266265005880 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 266265005881 cation binding site [ion binding]; other site 266265005882 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 266265005883 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 266265005884 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 266265005885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265005886 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265005887 putative substrate translocation pore; other site 266265005888 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 266265005889 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266265005890 DNA binding residues [nucleotide binding] 266265005891 putative dimer interface [polypeptide binding]; other site 266265005892 transcription termination factor Rho; Provisional; Region: rho; PRK09376 266265005893 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 266265005894 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 266265005895 RNA binding site [nucleotide binding]; other site 266265005896 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 266265005897 multimer interface [polypeptide binding]; other site 266265005898 Walker A motif; other site 266265005899 ATP binding site [chemical binding]; other site 266265005900 Walker B motif; other site 266265005901 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266265005902 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266265005903 catalytic residues [active] 266265005904 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 266265005905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265005906 Walker A motif; other site 266265005907 ATP binding site [chemical binding]; other site 266265005908 Walker B motif; other site 266265005909 arginine finger; other site 266265005910 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 266265005911 hypothetical protein; Validated; Region: PRK00153 266265005912 recombination protein RecR; Reviewed; Region: recR; PRK00076 266265005913 RecR protein; Region: RecR; pfam02132 266265005914 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 266265005915 putative active site [active] 266265005916 putative metal-binding site [ion binding]; other site 266265005917 tetramer interface [polypeptide binding]; other site 266265005918 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265005919 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265005920 NMT1-like family; Region: NMT1_2; pfam13379 266265005921 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265005922 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265005923 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265005924 Walker A/P-loop; other site 266265005925 ATP binding site [chemical binding]; other site 266265005926 Q-loop/lid; other site 266265005927 ABC transporter signature motif; other site 266265005928 Walker B; other site 266265005929 D-loop; other site 266265005930 H-loop/switch region; other site 266265005931 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265005932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265005933 dimer interface [polypeptide binding]; other site 266265005934 conserved gate region; other site 266265005935 putative PBP binding loops; other site 266265005936 ABC-ATPase subunit interface; other site 266265005937 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265005938 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 266265005939 NAD(P) binding site [chemical binding]; other site 266265005940 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 266265005941 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266265005942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265005943 S-adenosylmethionine binding site [chemical binding]; other site 266265005944 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 266265005945 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266265005946 Peptidase family M23; Region: Peptidase_M23; pfam01551 266265005947 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 266265005948 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266265005949 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265005950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265005951 DNA binding residues [nucleotide binding] 266265005952 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 266265005953 active site 266265005954 catalytic site [active] 266265005955 substrate binding site [chemical binding]; other site 266265005956 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 266265005957 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 266265005958 TRAM domain; Region: TRAM; cl01282 266265005959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265005960 S-adenosylmethionine binding site [chemical binding]; other site 266265005961 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 266265005962 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 266265005963 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266265005964 RNA binding surface [nucleotide binding]; other site 266265005965 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266265005966 active site 266265005967 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 266265005968 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 266265005969 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266265005970 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266265005971 putative acyltransferase; Provisional; Region: PRK05790 266265005972 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265005973 dimer interface [polypeptide binding]; other site 266265005974 active site 266265005975 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 266265005976 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266265005977 NAD(P) binding site [chemical binding]; other site 266265005978 homotetramer interface [polypeptide binding]; other site 266265005979 homodimer interface [polypeptide binding]; other site 266265005980 active site 266265005981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 266265005982 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 266265005983 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 266265005984 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 266265005985 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 266265005986 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266265005987 FMN binding site [chemical binding]; other site 266265005988 active site 266265005989 catalytic residues [active] 266265005990 substrate binding site [chemical binding]; other site 266265005991 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 266265005992 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266265005993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265005994 FeS/SAM binding site; other site 266265005995 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265005996 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266265005997 substrate binding site [chemical binding]; other site 266265005998 ATP binding site [chemical binding]; other site 266265005999 beta-ketothiolase; Provisional; Region: PRK09051 266265006000 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265006001 dimer interface [polypeptide binding]; other site 266265006002 active site 266265006003 cystathionine beta-lyase; Provisional; Region: PRK07050 266265006004 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266265006005 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265006006 catalytic residue [active] 266265006007 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 266265006008 phosphoserine phosphatase SerB; Region: serB; TIGR00338 266265006009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265006010 motif II; other site 266265006011 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266265006012 Cytochrome P450; Region: p450; cl12078 266265006013 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 266265006014 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 266265006015 putative DNA binding site [nucleotide binding]; other site 266265006016 putative homodimer interface [polypeptide binding]; other site 266265006017 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 266265006018 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 266265006019 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 266265006020 active site 266265006021 DNA binding site [nucleotide binding] 266265006022 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 266265006023 DNA binding site [nucleotide binding] 266265006024 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 266265006025 nucleotide binding site [chemical binding]; other site 266265006026 transcriptional activator TtdR; Provisional; Region: PRK09801 266265006027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006028 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265006029 putative effector binding pocket; other site 266265006030 dimerization interface [polypeptide binding]; other site 266265006031 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 266265006032 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 266265006033 putative NAD(P) binding site [chemical binding]; other site 266265006034 dimer interface [polypeptide binding]; other site 266265006035 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 266265006036 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 266265006037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265006038 Walker A/P-loop; other site 266265006039 ATP binding site [chemical binding]; other site 266265006040 Q-loop/lid; other site 266265006041 ABC transporter signature motif; other site 266265006042 Walker B; other site 266265006043 D-loop; other site 266265006044 H-loop/switch region; other site 266265006045 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 266265006046 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 266265006047 CHASE3 domain; Region: CHASE3; cl05000 266265006048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266265006049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265006050 dimer interface [polypeptide binding]; other site 266265006051 phosphorylation site [posttranslational modification] 266265006052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265006053 ATP binding site [chemical binding]; other site 266265006054 Mg2+ binding site [ion binding]; other site 266265006055 G-X-G motif; other site 266265006056 Response regulator receiver domain; Region: Response_reg; pfam00072 266265006057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265006058 active site 266265006059 phosphorylation site [posttranslational modification] 266265006060 intermolecular recognition site; other site 266265006061 dimerization interface [polypeptide binding]; other site 266265006062 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265006063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265006064 active site 266265006065 phosphorylation site [posttranslational modification] 266265006066 intermolecular recognition site; other site 266265006067 dimerization interface [polypeptide binding]; other site 266265006068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265006069 PAS fold; Region: PAS_3; pfam08447 266265006070 putative active site [active] 266265006071 heme pocket [chemical binding]; other site 266265006072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265006073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265006074 dimer interface [polypeptide binding]; other site 266265006075 phosphorylation site [posttranslational modification] 266265006076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265006077 ATP binding site [chemical binding]; other site 266265006078 Mg2+ binding site [ion binding]; other site 266265006079 G-X-G motif; other site 266265006080 Response regulator receiver domain; Region: Response_reg; pfam00072 266265006081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265006082 active site 266265006083 phosphorylation site [posttranslational modification] 266265006084 intermolecular recognition site; other site 266265006085 dimerization interface [polypeptide binding]; other site 266265006086 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 266265006087 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 266265006088 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266265006089 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266265006090 tetramer interface [polypeptide binding]; other site 266265006091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265006092 catalytic residue [active] 266265006093 acetylornithine deacetylase; Provisional; Region: PRK07522 266265006094 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 266265006095 metal binding site [ion binding]; metal-binding site 266265006096 putative dimer interface [polypeptide binding]; other site 266265006097 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 266265006098 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 266265006099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265006100 ATP binding site [chemical binding]; other site 266265006101 putative Mg++ binding site [ion binding]; other site 266265006102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265006103 nucleotide binding region [chemical binding]; other site 266265006104 ATP-binding site [chemical binding]; other site 266265006105 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 266265006106 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 266265006107 substrate binding site; other site 266265006108 dimer interface; other site 266265006109 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 266265006110 homotrimer interaction site [polypeptide binding]; other site 266265006111 zinc binding site [ion binding]; other site 266265006112 CDP-binding sites; other site 266265006113 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 266265006114 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265006115 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266265006116 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 266265006117 dimer interface [polypeptide binding]; other site 266265006118 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266265006119 catalytic triad [active] 266265006120 peroxidatic and resolving cysteines [active] 266265006121 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 266265006122 dimerization interface [polypeptide binding]; other site 266265006123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265006124 dimer interface [polypeptide binding]; other site 266265006125 phosphorylation site [posttranslational modification] 266265006126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265006127 ATP binding site [chemical binding]; other site 266265006128 Mg2+ binding site [ion binding]; other site 266265006129 G-X-G motif; other site 266265006130 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266265006131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265006132 active site 266265006133 phosphorylation site [posttranslational modification] 266265006134 intermolecular recognition site; other site 266265006135 dimerization interface [polypeptide binding]; other site 266265006136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265006137 DNA binding site [nucleotide binding] 266265006138 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 266265006139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 266265006140 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266265006141 active site lid residues [active] 266265006142 substrate binding pocket [chemical binding]; other site 266265006143 catalytic residues [active] 266265006144 substrate-Mg2+ binding site; other site 266265006145 aspartate-rich region 1; other site 266265006146 aspartate-rich region 2; other site 266265006147 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 266265006148 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265006149 MarR family; Region: MarR_2; pfam12802 266265006150 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 266265006151 trigger factor; Provisional; Region: tig; PRK01490 266265006152 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266265006153 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 266265006154 Clp protease; Region: CLP_protease; pfam00574 266265006155 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266265006156 oligomer interface [polypeptide binding]; other site 266265006157 active site residues [active] 266265006158 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 266265006159 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 266265006160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265006161 Walker A motif; other site 266265006162 ATP binding site [chemical binding]; other site 266265006163 Walker B motif; other site 266265006164 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266265006165 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 266265006166 Found in ATP-dependent protease La (LON); Region: LON; smart00464 266265006167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265006168 Walker A motif; other site 266265006169 ATP binding site [chemical binding]; other site 266265006170 Walker B motif; other site 266265006171 arginine finger; other site 266265006172 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 266265006173 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266265006174 IHF dimer interface [polypeptide binding]; other site 266265006175 IHF - DNA interface [nucleotide binding]; other site 266265006176 SurA N-terminal domain; Region: SurA_N_3; cl07813 266265006177 periplasmic folding chaperone; Provisional; Region: PRK10788 266265006178 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 266265006179 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266265006180 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 266265006181 active site 266265006182 catalytic triad [active] 266265006183 oxyanion hole [active] 266265006184 switch loop; other site 266265006185 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 266265006186 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266265006187 Walker A/P-loop; other site 266265006188 ATP binding site [chemical binding]; other site 266265006189 Q-loop/lid; other site 266265006190 ABC transporter signature motif; other site 266265006191 Walker B; other site 266265006192 D-loop; other site 266265006193 H-loop/switch region; other site 266265006194 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 266265006195 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 266265006196 active site 266265006197 dimer interface [polypeptide binding]; other site 266265006198 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 266265006199 dimer interface [polypeptide binding]; other site 266265006200 active site 266265006201 putative carbohydrate kinase; Provisional; Region: PRK10565 266265006202 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 266265006203 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 266265006204 putative substrate binding site [chemical binding]; other site 266265006205 putative ATP binding site [chemical binding]; other site 266265006206 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266265006207 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 266265006208 putative active site [active] 266265006209 putative Zn binding site [ion binding]; other site 266265006210 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 266265006211 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 266265006212 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 266265006213 dimerization interface [polypeptide binding]; other site 266265006214 ATP binding site [chemical binding]; other site 266265006215 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 266265006216 dimerization interface [polypeptide binding]; other site 266265006217 ATP binding site [chemical binding]; other site 266265006218 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 266265006219 putative active site [active] 266265006220 catalytic triad [active] 266265006221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265006222 non-specific DNA binding site [nucleotide binding]; other site 266265006223 salt bridge; other site 266265006224 sequence-specific DNA binding site [nucleotide binding]; other site 266265006225 HipA N-terminal domain; Region: Couple_hipA; pfam13657 266265006226 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 266265006227 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266265006228 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266265006229 SurA N-terminal domain; Region: SurA_N_3; cl07813 266265006230 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266265006231 BolA-like protein; Region: BolA; pfam01722 266265006232 intracellular septation protein A; Reviewed; Region: PRK00259 266265006233 methionine sulfoxide reductase B; Provisional; Region: PRK00222 266265006234 SelR domain; Region: SelR; pfam01641 266265006235 hypothetical protein; Validated; Region: PRK00029 266265006236 Uncharacterized conserved protein [Function unknown]; Region: COG0397 266265006237 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 266265006238 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 266265006239 dimer interface [polypeptide binding]; other site 266265006240 acyl-activating enzyme (AAE) consensus motif; other site 266265006241 putative active site [active] 266265006242 AMP binding site [chemical binding]; other site 266265006243 putative CoA binding site [chemical binding]; other site 266265006244 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265006245 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 266265006246 substrate binding site [chemical binding]; other site 266265006247 oxyanion hole (OAH) forming residues; other site 266265006248 trimer interface [polypeptide binding]; other site 266265006249 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265006250 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265006251 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265006252 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 266265006253 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265006254 dimer interface [polypeptide binding]; other site 266265006255 active site 266265006256 Water Stress and Hypersensitive response; Region: WHy; smart00769 266265006257 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266265006258 CoenzymeA binding site [chemical binding]; other site 266265006259 subunit interaction site [polypeptide binding]; other site 266265006260 PHB binding site; other site 266265006261 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 266265006262 Prostaglandin dehydrogenases; Region: PGDH; cd05288 266265006263 NAD(P) binding site [chemical binding]; other site 266265006264 substrate binding site [chemical binding]; other site 266265006265 dimer interface [polypeptide binding]; other site 266265006266 hypothetical protein; Provisional; Region: PRK06194 266265006267 classical (c) SDRs; Region: SDR_c; cd05233 266265006268 NAD(P) binding site [chemical binding]; other site 266265006269 active site 266265006270 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265006271 NRDE protein; Region: NRDE; cl01315 266265006272 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 266265006273 Cytochrome P450; Region: p450; cl12078 266265006274 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 266265006275 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266265006276 YceG-like family; Region: YceG; pfam02618 266265006277 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 266265006278 dimerization interface [polypeptide binding]; other site 266265006279 thymidylate kinase; Validated; Region: tmk; PRK00698 266265006280 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 266265006281 TMP-binding site; other site 266265006282 ATP-binding site [chemical binding]; other site 266265006283 DNA polymerase III subunit delta'; Validated; Region: PRK06964 266265006284 DNA polymerase III subunit delta'; Validated; Region: PRK08485 266265006285 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266265006286 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266265006287 active site 266265006288 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266265006289 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266265006290 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266265006291 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266265006292 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266265006293 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 266265006294 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266265006295 active site 266265006296 homotetramer interface [polypeptide binding]; other site 266265006297 Predicted ATPase [General function prediction only]; Region: COG4637 266265006298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265006299 Walker A/P-loop; other site 266265006300 ATP binding site [chemical binding]; other site 266265006301 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266265006302 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265006303 putative ADP-binding pocket [chemical binding]; other site 266265006304 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266265006305 hypothetical protein; Provisional; Region: PRK11505 266265006306 psiF repeat; Region: PsiF_repeat; pfam07769 266265006307 psiF repeat; Region: PsiF_repeat; pfam07769 266265006308 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266265006309 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266265006310 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 266265006311 Substrate binding site; other site 266265006312 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 266265006313 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266265006314 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266265006315 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266265006316 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266265006317 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266265006318 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 266265006319 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266265006320 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266265006321 active site 266265006322 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266265006323 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 266265006324 SLBB domain; Region: SLBB; pfam10531 266265006325 SLBB domain; Region: SLBB; pfam10531 266265006326 tyrosine kinase; Provisional; Region: PRK11519 266265006327 Chain length determinant protein; Region: Wzz; cl15801 266265006328 Chain length determinant protein; Region: Wzz; cl15801 266265006329 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266265006330 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265006331 P-loop; other site 266265006332 Magnesium ion binding site [ion binding]; other site 266265006333 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266265006334 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 266265006335 active site 266265006336 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265006337 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265006338 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265006339 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265006340 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265006341 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265006342 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266265006343 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266265006344 NADP-binding site; other site 266265006345 homotetramer interface [polypeptide binding]; other site 266265006346 substrate binding site [chemical binding]; other site 266265006347 homodimer interface [polypeptide binding]; other site 266265006348 active site 266265006349 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 266265006350 active site 266265006351 catalytic triad [active] 266265006352 oxyanion hole [active] 266265006353 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265006354 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266265006355 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 266265006356 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 266265006357 putative ADP-binding pocket [chemical binding]; other site 266265006358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265006359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265006360 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265006361 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265006362 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266265006363 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 266265006364 active site 266265006365 tetramer interface; other site 266265006366 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 266265006367 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 266265006368 active site 266265006369 Domain of unknown function (DUF336); Region: DUF336; cl01249 266265006370 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 266265006371 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266265006372 Cysteine-rich domain; Region: CCG; pfam02754 266265006373 Cysteine-rich domain; Region: CCG; pfam02754 266265006374 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 266265006375 FAD binding domain; Region: FAD_binding_4; pfam01565 266265006376 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 266265006377 FAD binding domain; Region: FAD_binding_4; pfam01565 266265006378 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 266265006379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265006380 DNA-binding site [nucleotide binding]; DNA binding site 266265006381 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266265006382 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 266265006383 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 266265006384 MOSC domain; Region: MOSC; pfam03473 266265006385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265006386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265006387 active site 266265006388 phosphorylation site [posttranslational modification] 266265006389 intermolecular recognition site; other site 266265006390 dimerization interface [polypeptide binding]; other site 266265006391 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266265006392 active site 266265006393 SAM binding site [chemical binding]; other site 266265006394 homodimer interface [polypeptide binding]; other site 266265006395 nitrite reductase subunit NirD; Provisional; Region: PRK14989 266265006396 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265006397 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266265006398 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266265006399 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 266265006400 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266265006401 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 266265006402 [4Fe-4S] binding site [ion binding]; other site 266265006403 molybdopterin cofactor binding site; other site 266265006404 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266265006405 molybdopterin cofactor binding site; other site 266265006406 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 266265006407 Flavodoxin; Region: Flavodoxin_1; pfam00258 266265006408 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 266265006409 FAD binding pocket [chemical binding]; other site 266265006410 FAD binding motif [chemical binding]; other site 266265006411 catalytic residues [active] 266265006412 NAD binding pocket [chemical binding]; other site 266265006413 phosphate binding motif [ion binding]; other site 266265006414 beta-alpha-beta structure motif; other site 266265006415 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 266265006416 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 266265006417 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265006418 putative CheW interface [polypeptide binding]; other site 266265006419 MgtC family; Region: MgtC; pfam02308 266265006420 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 266265006421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265006422 S-adenosylmethionine binding site [chemical binding]; other site 266265006423 short chain dehydrogenase; Provisional; Region: PRK06180 266265006424 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265006425 NADP binding site [chemical binding]; other site 266265006426 active site 266265006427 steroid binding site; other site 266265006428 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 266265006429 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265006430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265006431 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265006432 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 266265006433 putative C-terminal domain interface [polypeptide binding]; other site 266265006434 putative GSH binding site (G-site) [chemical binding]; other site 266265006435 putative dimer interface [polypeptide binding]; other site 266265006436 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 266265006437 putative N-terminal domain interface [polypeptide binding]; other site 266265006438 putative dimer interface [polypeptide binding]; other site 266265006439 putative substrate binding pocket (H-site) [chemical binding]; other site 266265006440 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 266265006441 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 266265006442 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 266265006443 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 266265006444 Transglycosylase; Region: Transgly; pfam00912 266265006445 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266265006446 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 266265006447 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 266265006448 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265006449 Helix-turn-helix domain; Region: HTH_18; pfam12833 266265006450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265006451 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 266265006452 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266265006453 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266265006454 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265006455 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265006456 active site 266265006457 catalytic tetrad [active] 266265006458 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 266265006459 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266265006460 ATP binding site [chemical binding]; other site 266265006461 Mg++ binding site [ion binding]; other site 266265006462 motif III; other site 266265006463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265006464 nucleotide binding region [chemical binding]; other site 266265006465 ATP-binding site [chemical binding]; other site 266265006466 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 266265006467 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 266265006468 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 266265006469 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 266265006470 putative NADH binding site [chemical binding]; other site 266265006471 putative active site [active] 266265006472 nudix motif; other site 266265006473 putative metal binding site [ion binding]; other site 266265006474 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265006475 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265006476 Cytochrome c; Region: Cytochrom_C; pfam00034 266265006477 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 266265006478 Subunit I/III interface [polypeptide binding]; other site 266265006479 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266265006480 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266265006481 D-pathway; other site 266265006482 Putative ubiquinol binding site [chemical binding]; other site 266265006483 Low-spin heme (heme b) binding site [chemical binding]; other site 266265006484 Putative water exit pathway; other site 266265006485 Binuclear center (heme o3/CuB) [ion binding]; other site 266265006486 K-pathway; other site 266265006487 Putative proton exit pathway; other site 266265006488 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 266265006489 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266265006490 Cytochrome c; Region: Cytochrom_C; pfam00034 266265006491 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 266265006492 RNA polymerase sigma factor; Provisional; Region: PRK12536 266265006493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265006494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265006495 DNA binding residues [nucleotide binding] 266265006496 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 266265006497 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 266265006498 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 266265006499 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 266265006500 Moco binding site; other site 266265006501 metal coordination site [ion binding]; other site 266265006502 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265006503 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265006504 active site 266265006505 non-prolyl cis peptide bond; other site 266265006506 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265006507 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265006508 active site 266265006509 non-prolyl cis peptide bond; other site 266265006510 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 266265006511 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265006512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266265006513 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265006514 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265006515 Walker A/P-loop; other site 266265006516 ATP binding site [chemical binding]; other site 266265006517 Q-loop/lid; other site 266265006518 ABC transporter signature motif; other site 266265006519 Walker B; other site 266265006520 D-loop; other site 266265006521 H-loop/switch region; other site 266265006522 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265006523 NMT1-like family; Region: NMT1_2; pfam13379 266265006524 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265006525 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266265006526 Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375 266265006527 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266265006528 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 266265006529 Moco binding site; other site 266265006530 metal coordination site [ion binding]; other site 266265006531 dimerization interface [polypeptide binding]; other site 266265006532 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265006533 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265006534 substrate binding pocket [chemical binding]; other site 266265006535 membrane-bound complex binding site; other site 266265006536 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265006537 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265006538 Walker A/P-loop; other site 266265006539 ATP binding site [chemical binding]; other site 266265006540 Q-loop/lid; other site 266265006541 ABC transporter signature motif; other site 266265006542 Walker B; other site 266265006543 D-loop; other site 266265006544 H-loop/switch region; other site 266265006545 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265006546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265006547 dimer interface [polypeptide binding]; other site 266265006548 ABC-ATPase subunit interface; other site 266265006549 putative PBP binding loops; other site 266265006550 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266265006551 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265006552 benzoate transport; Region: 2A0115; TIGR00895 266265006553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265006554 putative substrate translocation pore; other site 266265006555 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265006556 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265006557 substrate binding pocket [chemical binding]; other site 266265006558 membrane-bound complex binding site; other site 266265006559 hinge residues; other site 266265006560 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265006561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265006562 ABC-ATPase subunit interface; other site 266265006563 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265006564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265006565 dimer interface [polypeptide binding]; other site 266265006566 putative PBP binding loops; other site 266265006567 ABC-ATPase subunit interface; other site 266265006568 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265006569 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265006570 Walker A/P-loop; other site 266265006571 ATP binding site [chemical binding]; other site 266265006572 Q-loop/lid; other site 266265006573 ABC transporter signature motif; other site 266265006574 Walker B; other site 266265006575 D-loop; other site 266265006576 H-loop/switch region; other site 266265006577 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265006578 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265006579 active site 266265006580 non-prolyl cis peptide bond; other site 266265006581 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265006582 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266265006583 active site 266265006584 iron coordination sites [ion binding]; other site 266265006585 substrate binding pocket [chemical binding]; other site 266265006586 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266265006587 PLD-like domain; Region: PLDc_2; pfam13091 266265006588 putative active site [active] 266265006589 catalytic site [active] 266265006590 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266265006591 PLD-like domain; Region: PLDc_2; pfam13091 266265006592 putative active site [active] 266265006593 catalytic site [active] 266265006594 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 266265006595 putative active site [active] 266265006596 putative metal binding site [ion binding]; other site 266265006597 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265006598 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265006599 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266265006600 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266265006601 YHS domain; Region: YHS; pfam04945 266265006602 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 266265006603 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266265006604 metal ion-dependent adhesion site (MIDAS); other site 266265006605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265006606 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 266265006607 Walker A motif; other site 266265006608 ATP binding site [chemical binding]; other site 266265006609 Walker B motif; other site 266265006610 arginine finger; other site 266265006611 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 266265006612 putative hydrophobic ligand binding site [chemical binding]; other site 266265006613 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 266265006614 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265006615 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265006616 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265006617 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265006618 catalytic loop [active] 266265006619 iron binding site [ion binding]; other site 266265006620 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265006621 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265006622 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266265006623 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 266265006624 LytTr DNA-binding domain; Region: LytTR; smart00850 266265006625 Oxygen tolerance; Region: BatD; pfam13584 266265006626 von Willebrand factor type A domain; Region: VWA_2; pfam13519 266265006627 metal ion-dependent adhesion site (MIDAS); other site 266265006628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265006629 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265006630 TPR motif; other site 266265006631 binding surface 266265006632 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 266265006633 metal ion-dependent adhesion site (MIDAS); other site 266265006634 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 266265006635 Protein of unknown function DUF58; Region: DUF58; pfam01882 266265006636 MoxR-like ATPases [General function prediction only]; Region: COG0714 266265006637 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 266265006638 Walker A motif; other site 266265006639 ATP binding site [chemical binding]; other site 266265006640 Walker B motif; other site 266265006641 arginine finger; other site 266265006642 Uncharacterized conserved protein [Function unknown]; Region: COG1262 266265006643 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266265006644 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 266265006645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265006646 motif II; other site 266265006647 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 266265006648 Sulfatase; Region: Sulfatase; pfam00884 266265006649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266265006650 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 266265006651 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 266265006652 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 266265006653 mce related protein; Region: MCE; pfam02470 266265006654 mce related protein; Region: MCE; pfam02470 266265006655 mce related protein; Region: MCE; pfam02470 266265006656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 266265006657 Protein of unknown function (DUF330); Region: DUF330; pfam03886 266265006658 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 266265006659 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 266265006660 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 266265006661 nucleotide binding site [chemical binding]; other site 266265006662 putative NEF/HSP70 interaction site [polypeptide binding]; other site 266265006663 SBD interface [polypeptide binding]; other site 266265006664 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 266265006665 nucleotide binding site [chemical binding]; other site 266265006666 putative NEF/HSP70 interaction site [polypeptide binding]; other site 266265006667 SBD interface [polypeptide binding]; other site 266265006668 DNA-K related protein; Region: DUF3731; pfam12531 266265006669 Protein of unknown function (DUF1670); Region: DUF1670; pfam07900 266265006670 Homeodomain-like domain; Region: HTH_23; pfam13384 266265006671 GAF domain; Region: GAF; pfam01590 266265006672 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266265006673 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265006674 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265006675 metal binding site [ion binding]; metal-binding site 266265006676 active site 266265006677 I-site; other site 266265006678 cytosine deaminase; Provisional; Region: PRK05985 266265006679 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266265006680 active site 266265006681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265006682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006683 Bacterial regulatory protein, arsR family; Region: HTH_5; pfam01022 266265006684 Winged helix-turn helix; Region: HTH_29; pfam13551 266265006685 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 266265006686 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 266265006687 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265006688 catalytic residue [active] 266265006689 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 266265006690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265006692 dimerization interface [polypeptide binding]; other site 266265006693 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265006694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265006695 NAD(P) binding site [chemical binding]; other site 266265006696 active site 266265006697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265006698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006699 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266265006700 putative dimerization interface [polypeptide binding]; other site 266265006701 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265006702 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266265006703 FMN-binding pocket [chemical binding]; other site 266265006704 flavin binding motif; other site 266265006705 phosphate binding motif [ion binding]; other site 266265006706 beta-alpha-beta structure motif; other site 266265006707 NAD binding pocket [chemical binding]; other site 266265006708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265006709 catalytic loop [active] 266265006710 iron binding site [ion binding]; other site 266265006711 Muconolactone delta-isomerase; Region: MIase; pfam02426 266265006712 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 266265006713 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 266265006714 dimer interface [polypeptide binding]; other site 266265006715 active site 266265006716 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 266265006717 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 266265006718 octamer interface [polypeptide binding]; other site 266265006719 active site 266265006720 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266265006721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006722 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 266265006723 dimerizarion interface [polypeptide binding]; other site 266265006724 CrgA pocket; other site 266265006725 substrate binding pocket [chemical binding]; other site 266265006726 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 266265006727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006728 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 266265006729 substrate binding pocket [chemical binding]; other site 266265006730 dimerization interface [polypeptide binding]; other site 266265006731 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 266265006732 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265006733 [2Fe-2S] cluster binding site [ion binding]; other site 266265006734 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 266265006735 putative alpha subunit interface [polypeptide binding]; other site 266265006736 putative active site [active] 266265006737 putative substrate binding site [chemical binding]; other site 266265006738 Fe binding site [ion binding]; other site 266265006739 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265006740 inter-subunit interface; other site 266265006741 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265006742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265006743 putative substrate translocation pore; other site 266265006744 SnoaL-like domain; Region: SnoaL_4; pfam13577 266265006745 Amidase; Region: Amidase; cl11426 266265006746 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266265006747 Amidase; Region: Amidase; cl11426 266265006748 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265006749 classical (c) SDRs; Region: SDR_c; cd05233 266265006750 NAD(P) binding site [chemical binding]; other site 266265006751 active site 266265006752 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 266265006753 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 266265006754 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 266265006755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265006756 Walker A motif; other site 266265006757 ATP binding site [chemical binding]; other site 266265006758 Walker B motif; other site 266265006759 arginine finger; other site 266265006760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265006761 Walker A motif; other site 266265006762 ATP binding site [chemical binding]; other site 266265006763 Walker B motif; other site 266265006764 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266265006765 Protein of unknown function (DUF770); Region: DUF770; pfam05591 266265006766 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 266265006767 Protein of unknown function (DUF877); Region: DUF877; pfam05943 266265006768 Protein of unknown function (DUF796); Region: DUF796; pfam05638 266265006769 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 266265006770 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 266265006771 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 266265006772 hypothetical protein; Provisional; Region: PRK08126 266265006773 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 266265006774 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265006775 ligand binding site [chemical binding]; other site 266265006776 putative transposase OrfB; Reviewed; Region: PHA02517 266265006777 HTH-like domain; Region: HTH_21; pfam13276 266265006778 Integrase core domain; Region: rve; pfam00665 266265006779 Integrase core domain; Region: rve_3; pfam13683 266265006780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265006781 Transposase; Region: HTH_Tnp_1; pfam01527 266265006782 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 266265006783 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 266265006784 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 266265006785 CopC domain; Region: CopC; pfam04234 266265006786 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 266265006787 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266265006788 ProQ/FINO family; Region: ProQ; pfam04352 266265006789 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 266265006790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265006791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265006793 dimerization interface [polypeptide binding]; other site 266265006794 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265006795 enoyl-CoA hydratase; Provisional; Region: PRK06688 266265006796 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265006797 substrate binding site [chemical binding]; other site 266265006798 oxyanion hole (OAH) forming residues; other site 266265006799 trimer interface [polypeptide binding]; other site 266265006800 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265006801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265006802 acyl-activating enzyme (AAE) consensus motif; other site 266265006803 AMP binding site [chemical binding]; other site 266265006804 active site 266265006805 CoA binding site [chemical binding]; other site 266265006806 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 266265006807 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265006808 catalytic loop [active] 266265006809 iron binding site [ion binding]; other site 266265006810 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265006811 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265006812 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266265006813 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265006814 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265006815 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265006816 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 266265006817 putative hydrophobic ligand binding site [chemical binding]; other site 266265006818 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 266265006819 Flavoprotein; Region: Flavoprotein; pfam02441 266265006820 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 266265006821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265006822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265006824 dimerization interface [polypeptide binding]; other site 266265006825 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 266265006826 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 266265006827 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 266265006828 ligand binding site; other site 266265006829 Ubiquitin-like proteins; Region: UBQ; cl00155 266265006830 charged pocket; other site 266265006831 hydrophobic patch; other site 266265006832 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265006833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265006834 active site 266265006835 phosphorylation site [posttranslational modification] 266265006836 intermolecular recognition site; other site 266265006837 dimerization interface [polypeptide binding]; other site 266265006838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265006839 DNA binding site [nucleotide binding] 266265006840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265006841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266265006842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265006843 dimer interface [polypeptide binding]; other site 266265006844 phosphorylation site [posttranslational modification] 266265006845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265006846 ATP binding site [chemical binding]; other site 266265006847 G-X-G motif; other site 266265006848 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 266265006849 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 266265006850 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 266265006851 ligand binding site; other site 266265006852 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 266265006853 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 266265006854 B12 binding site [chemical binding]; other site 266265006855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265006856 FeS/SAM binding site; other site 266265006857 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266265006858 DNA-binding site [nucleotide binding]; DNA binding site 266265006859 RNA-binding motif; other site 266265006860 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265006861 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266265006862 tetramerization interface [polypeptide binding]; other site 266265006863 NAD(P) binding site [chemical binding]; other site 266265006864 catalytic residues [active] 266265006865 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 266265006866 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265006867 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 266265006868 putative C-terminal domain interface [polypeptide binding]; other site 266265006869 putative GSH binding site (G-site) [chemical binding]; other site 266265006870 putative dimer interface [polypeptide binding]; other site 266265006871 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 266265006872 N-terminal domain interface [polypeptide binding]; other site 266265006873 dimer interface [polypeptide binding]; other site 266265006874 substrate binding pocket (H-site) [chemical binding]; other site 266265006875 Chromate transporter; Region: Chromate_transp; pfam02417 266265006876 Chromate transporter; Region: Chromate_transp; pfam02417 266265006877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266265006878 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266265006879 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265006880 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266265006881 active site 266265006882 metal binding site [ion binding]; metal-binding site 266265006883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 266265006884 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265006885 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266265006886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265006887 DNA-binding site [nucleotide binding]; DNA binding site 266265006888 FCD domain; Region: FCD; pfam07729 266265006889 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265006890 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265006891 trimer interface [polypeptide binding]; other site 266265006892 eyelet of channel; other site 266265006893 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266265006894 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265006895 P-loop; other site 266265006896 Magnesium ion binding site [ion binding]; other site 266265006897 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265006898 Magnesium ion binding site [ion binding]; other site 266265006899 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 266265006900 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265006901 threonine dehydratase; Reviewed; Region: PRK09224 266265006902 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266265006903 tetramer interface [polypeptide binding]; other site 266265006904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265006905 catalytic residue [active] 266265006906 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 266265006907 putative Ile/Val binding site [chemical binding]; other site 266265006908 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 266265006909 putative Ile/Val binding site [chemical binding]; other site 266265006910 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 266265006911 acyl carrier protein; Provisional; Region: PRK07081 266265006912 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 266265006913 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 266265006914 acyl-activating enzyme (AAE) consensus motif; other site 266265006915 AMP binding site [chemical binding]; other site 266265006916 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 266265006917 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 266265006918 Predicted integral membrane protein [Function unknown]; Region: COG0392 266265006919 Uncharacterized conserved protein [Function unknown]; Region: COG2898 266265006920 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 266265006921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265006922 putative transporter; Provisional; Region: PRK10504 266265006923 putative substrate translocation pore; other site 266265006924 Predicted membrane protein [Function unknown]; Region: COG2323 266265006925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266265006926 active site 266265006927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265006928 S-adenosylmethionine binding site [chemical binding]; other site 266265006929 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265006930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265006931 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266265006932 putative active site [active] 266265006933 heme pocket [chemical binding]; other site 266265006934 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266265006935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265006936 putative active site [active] 266265006937 heme pocket [chemical binding]; other site 266265006938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265006939 dimer interface [polypeptide binding]; other site 266265006940 phosphorylation site [posttranslational modification] 266265006941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265006942 ATP binding site [chemical binding]; other site 266265006943 Mg2+ binding site [ion binding]; other site 266265006944 G-X-G motif; other site 266265006945 Response regulator receiver domain; Region: Response_reg; pfam00072 266265006946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265006947 active site 266265006948 phosphorylation site [posttranslational modification] 266265006949 intermolecular recognition site; other site 266265006950 dimerization interface [polypeptide binding]; other site 266265006951 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266265006952 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265006953 Tar ligand binding domain homologue; Region: TarH; pfam02203 266265006954 dimer interface [polypeptide binding]; other site 266265006955 ligand binding site [chemical binding]; other site 266265006956 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266265006957 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265006958 dimerization interface [polypeptide binding]; other site 266265006959 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265006960 dimer interface [polypeptide binding]; other site 266265006961 putative CheW interface [polypeptide binding]; other site 266265006962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265006963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265006965 dimerization interface [polypeptide binding]; other site 266265006966 putative transporter; Provisional; Region: PRK10504 266265006967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265006968 putative substrate translocation pore; other site 266265006969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265006970 short chain dehydrogenase; Provisional; Region: PRK06197 266265006971 NAD(P) binding site [chemical binding]; other site 266265006972 active site 266265006973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265006974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265006975 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265006976 putative effector binding pocket; other site 266265006977 dimerization interface [polypeptide binding]; other site 266265006978 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266265006979 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 266265006980 amidohydrolase; Provisional; Region: PRK12393 266265006981 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 266265006982 active site 266265006983 putative substrate binding pocket [chemical binding]; other site 266265006984 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265006985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265006986 dimer interface [polypeptide binding]; other site 266265006987 ABC-ATPase subunit interface; other site 266265006988 putative PBP binding loops; other site 266265006989 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265006990 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265006991 Walker A/P-loop; other site 266265006992 ATP binding site [chemical binding]; other site 266265006993 Q-loop/lid; other site 266265006994 ABC transporter signature motif; other site 266265006995 Walker B; other site 266265006996 D-loop; other site 266265006997 H-loop/switch region; other site 266265006998 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265006999 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265007000 [2Fe-2S] cluster binding site [ion binding]; other site 266265007001 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266265007002 hydrophobic ligand binding site; other site 266265007003 NMT1/THI5 like; Region: NMT1; pfam09084 266265007004 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266265007005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266265007006 active site 266265007007 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 266265007008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265007009 putative substrate translocation pore; other site 266265007010 SpoVR family protein; Provisional; Region: PRK11767 266265007011 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 266265007012 hypothetical protein; Provisional; Region: PRK05325 266265007013 PrkA family serine protein kinase; Provisional; Region: PRK15455 266265007014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266265007015 Walker A motif; other site 266265007016 ATP binding site [chemical binding]; other site 266265007017 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 266265007018 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265007019 Tar ligand binding domain homologue; Region: TarH; pfam02203 266265007020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265007021 dimerization interface [polypeptide binding]; other site 266265007022 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265007023 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265007024 dimer interface [polypeptide binding]; other site 266265007025 putative CheW interface [polypeptide binding]; other site 266265007026 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265007027 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265007028 DNA binding site [nucleotide binding] 266265007029 domain linker motif; other site 266265007030 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266265007031 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 266265007032 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265007033 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265007034 TM-ABC transporter signature motif; other site 266265007035 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265007036 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265007037 Walker A/P-loop; other site 266265007038 ATP binding site [chemical binding]; other site 266265007039 Q-loop/lid; other site 266265007040 ABC transporter signature motif; other site 266265007041 Walker B; other site 266265007042 D-loop; other site 266265007043 H-loop/switch region; other site 266265007044 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265007045 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266265007046 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266265007047 ligand binding site [chemical binding]; other site 266265007048 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266265007049 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 266265007050 oligomer interface [polypeptide binding]; other site 266265007051 metal binding site [ion binding]; metal-binding site 266265007052 metal binding site [ion binding]; metal-binding site 266265007053 putative Cl binding site [ion binding]; other site 266265007054 basic sphincter; other site 266265007055 hydrophobic gate; other site 266265007056 periplasmic entrance; other site 266265007057 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 266265007058 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 266265007059 AAA domain; Region: AAA_33; pfam13671 266265007060 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266265007061 active site 266265007062 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 266265007063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265007064 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 266265007065 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266265007066 AsnC family; Region: AsnC_trans_reg; pfam01037 266265007067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265007068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265007069 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 266265007070 putative effector binding pocket; other site 266265007071 putative dimerization interface [polypeptide binding]; other site 266265007072 LTXXQ motif family protein; Region: LTXXQ; pfam07813 266265007073 PGDYG protein; Region: PGDYG; pfam14083 266265007074 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 266265007075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265007076 putative substrate translocation pore; other site 266265007077 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 266265007078 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 266265007079 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265007080 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265007081 DNA binding site [nucleotide binding] 266265007082 domain linker motif; other site 266265007083 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 266265007084 putative dimerization interface [polypeptide binding]; other site 266265007085 putative ligand binding site [chemical binding]; other site 266265007086 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 266265007087 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 266265007088 dimerization interface [polypeptide binding]; other site 266265007089 ligand binding site [chemical binding]; other site 266265007090 NADP binding site [chemical binding]; other site 266265007091 catalytic site [active] 266265007092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265007093 D-galactonate transporter; Region: 2A0114; TIGR00893 266265007094 putative substrate translocation pore; other site 266265007095 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265007096 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266265007097 substrate binding site [chemical binding]; other site 266265007098 ATP binding site [chemical binding]; other site 266265007099 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266265007100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265007101 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 266265007102 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 266265007103 putative dimerization interface [polypeptide binding]; other site 266265007104 Predicted membrane protein [Function unknown]; Region: COG2855 266265007105 glutathione s-transferase; Provisional; Region: PTZ00057 266265007106 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 266265007107 GSH binding site (G-site) [chemical binding]; other site 266265007108 C-terminal domain interface [polypeptide binding]; other site 266265007109 dimer interface [polypeptide binding]; other site 266265007110 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 266265007111 dimer interface [polypeptide binding]; other site 266265007112 N-terminal domain interface [polypeptide binding]; other site 266265007113 substrate binding pocket (H-site) [chemical binding]; other site 266265007114 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 266265007115 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 266265007116 Cl- selectivity filter; other site 266265007117 Cl- binding residues [ion binding]; other site 266265007118 pore gating glutamate residue; other site 266265007119 dimer interface [polypeptide binding]; other site 266265007120 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 266265007121 Phospholipase B; Region: Phospholip_B; pfam04916 266265007122 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 266265007123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265007124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265007125 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265007126 putative effector binding pocket; other site 266265007127 dimerization interface [polypeptide binding]; other site 266265007128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265007129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265007130 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265007131 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265007132 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266265007133 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265007134 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266265007135 RHS Repeat; Region: RHS_repeat; pfam05593 266265007136 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 266265007137 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266265007138 putative acyl-acceptor binding pocket; other site 266265007139 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 266265007140 Transglycosylase; Region: Transgly; pfam00912 266265007141 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266265007142 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 266265007143 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265007144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265007145 TPR motif; other site 266265007146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265007147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265007148 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266265007149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266265007150 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265007151 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265007152 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265007153 dimer interface [polypeptide binding]; other site 266265007154 putative CheW interface [polypeptide binding]; other site 266265007155 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265007156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265007157 dimer interface [polypeptide binding]; other site 266265007158 conserved gate region; other site 266265007159 putative PBP binding loops; other site 266265007160 ABC-ATPase subunit interface; other site 266265007161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265007162 dimer interface [polypeptide binding]; other site 266265007163 conserved gate region; other site 266265007164 putative PBP binding loops; other site 266265007165 ABC-ATPase subunit interface; other site 266265007166 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 266265007167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265007168 Walker A/P-loop; other site 266265007169 ATP binding site [chemical binding]; other site 266265007170 Q-loop/lid; other site 266265007171 ABC transporter signature motif; other site 266265007172 Walker B; other site 266265007173 D-loop; other site 266265007174 H-loop/switch region; other site 266265007175 TOBE domain; Region: TOBE_2; pfam08402 266265007176 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 266265007177 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266265007178 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 266265007179 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266265007180 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 266265007181 dimerization interface [polypeptide binding]; other site 266265007182 substrate binding site [chemical binding]; other site 266265007183 active site 266265007184 calcium binding site [ion binding]; other site 266265007185 Predicted Fe-S protein [General function prediction only]; Region: COG3313 266265007186 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 266265007187 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 266265007188 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266265007189 FMN binding site [chemical binding]; other site 266265007190 substrate binding site [chemical binding]; other site 266265007191 putative catalytic residue [active] 266265007192 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266265007193 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265007194 NAD binding site [chemical binding]; other site 266265007195 catalytic residues [active] 266265007196 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 266265007197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265007198 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265007199 ABC transporter; Region: ABC_tran_2; pfam12848 266265007200 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265007201 Dodecin; Region: Dodecin; pfam07311 266265007202 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266265007203 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266265007204 putative ligand binding site [chemical binding]; other site 266265007205 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266265007206 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265007207 TM-ABC transporter signature motif; other site 266265007208 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265007209 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266265007210 TM-ABC transporter signature motif; other site 266265007211 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266265007212 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265007213 Walker A/P-loop; other site 266265007214 ATP binding site [chemical binding]; other site 266265007215 Q-loop/lid; other site 266265007216 ABC transporter signature motif; other site 266265007217 Walker B; other site 266265007218 D-loop; other site 266265007219 H-loop/switch region; other site 266265007220 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265007221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265007222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265007223 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 266265007224 putative substrate binding pocket [chemical binding]; other site 266265007225 putative dimerization interface [polypeptide binding]; other site 266265007226 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 266265007227 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 266265007228 active site 266265007229 putative substrate binding pocket [chemical binding]; other site 266265007230 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 266265007231 active site 266265007232 homotetramer interface [polypeptide binding]; other site 266265007233 Predicted membrane protein [Function unknown]; Region: COG3748 266265007234 Protein of unknown function (DUF989); Region: DUF989; pfam06181 266265007235 Cytochrome c; Region: Cytochrom_C; pfam00034 266265007236 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265007237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265007238 non-specific DNA binding site [nucleotide binding]; other site 266265007239 salt bridge; other site 266265007240 sequence-specific DNA binding site [nucleotide binding]; other site 266265007241 HipA N-terminal domain; Region: Couple_hipA; pfam13657 266265007242 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266265007243 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266265007244 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 266265007245 ureidoglycolate hydrolase; Provisional; Region: PRK03606 266265007246 allantoicase; Provisional; Region: PRK13257 266265007247 Allantoicase repeat; Region: Allantoicase; pfam03561 266265007248 Allantoicase repeat; Region: Allantoicase; pfam03561 266265007249 OHCU decarboxylase; Region: UHCUDC; TIGR03164 266265007250 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 266265007251 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 266265007252 active site 266265007253 catalytic site [active] 266265007254 tetramer interface [polypeptide binding]; other site 266265007255 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 266265007256 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 266265007257 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266265007258 Na binding site [ion binding]; other site 266265007259 putative substrate binding site [chemical binding]; other site 266265007260 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265007261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265007262 DNA-binding site [nucleotide binding]; DNA binding site 266265007263 FCD domain; Region: FCD; pfam07729 266265007264 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 266265007265 dimer interface [polypeptide binding]; other site 266265007266 catalytic triad [active] 266265007267 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266265007268 nucleoside/Zn binding site; other site 266265007269 dimer interface [polypeptide binding]; other site 266265007270 catalytic motif [active] 266265007271 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 266265007272 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 266265007273 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 266265007274 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 266265007275 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265007276 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 266265007277 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 266265007278 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265007279 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266265007280 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266265007281 Walker A/P-loop; other site 266265007282 ATP binding site [chemical binding]; other site 266265007283 Q-loop/lid; other site 266265007284 ABC transporter signature motif; other site 266265007285 Walker B; other site 266265007286 D-loop; other site 266265007287 H-loop/switch region; other site 266265007288 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266265007289 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266265007290 Walker A/P-loop; other site 266265007291 ATP binding site [chemical binding]; other site 266265007292 Q-loop/lid; other site 266265007293 ABC transporter signature motif; other site 266265007294 Walker B; other site 266265007295 D-loop; other site 266265007296 H-loop/switch region; other site 266265007297 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266265007298 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 266265007299 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266265007300 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266265007301 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 266265007302 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 266265007303 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266265007304 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266265007305 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 266265007306 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 266265007307 Cl binding site [ion binding]; other site 266265007308 oligomer interface [polypeptide binding]; other site 266265007309 Repair protein; Region: Repair_PSII; pfam04536 266265007310 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 266265007311 Repair protein; Region: Repair_PSII; pfam04536 266265007312 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 266265007313 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266265007314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265007315 Walker A motif; other site 266265007316 ATP binding site [chemical binding]; other site 266265007317 Walker B motif; other site 266265007318 arginine finger; other site 266265007319 Peptidase family M41; Region: Peptidase_M41; pfam01434 266265007320 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 266265007321 BON domain; Region: BON; pfam04972 266265007322 BON domain; Region: BON; pfam04972 266265007323 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 266265007324 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265007325 active site 266265007326 ChaB; Region: ChaB; cl01887 266265007327 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 266265007328 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 266265007329 BON domain; Region: BON; pfam04972 266265007330 BON domain; Region: BON; pfam04972 266265007331 BON domain; Region: BON; pfam04972 266265007332 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266265007333 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265007334 Ligand Binding Site [chemical binding]; other site 266265007335 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265007336 Ligand Binding Site [chemical binding]; other site 266265007337 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 266265007338 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265007339 Ligand Binding Site [chemical binding]; other site 266265007340 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 266265007341 Clp amino terminal domain; Region: Clp_N; pfam02861 266265007342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265007343 Walker A motif; other site 266265007344 ATP binding site [chemical binding]; other site 266265007345 Walker B motif; other site 266265007346 arginine finger; other site 266265007347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265007348 Walker A motif; other site 266265007349 ATP binding site [chemical binding]; other site 266265007350 Walker B motif; other site 266265007351 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 266265007352 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 266265007353 core domain interface [polypeptide binding]; other site 266265007354 delta subunit interface [polypeptide binding]; other site 266265007355 epsilon subunit interface [polypeptide binding]; other site 266265007356 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 266265007357 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266265007358 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265007359 Walker A motif; other site 266265007360 ATP binding site [chemical binding]; other site 266265007361 Walker B motif; other site 266265007362 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266265007363 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 266265007364 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 266265007365 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 266265007366 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 266265007367 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 266265007368 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 266265007369 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 266265007370 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 266265007371 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 266265007372 gamma subunit interface [polypeptide binding]; other site 266265007373 epsilon subunit interface [polypeptide binding]; other site 266265007374 LBP interface [polypeptide binding]; other site 266265007375 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 266265007376 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266265007377 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266265007378 alpha subunit interaction interface [polypeptide binding]; other site 266265007379 Walker A motif; other site 266265007380 ATP binding site [chemical binding]; other site 266265007381 Walker B motif; other site 266265007382 inhibitor binding site; inhibition site 266265007383 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266265007384 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 266265007385 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 266265007386 arginine deiminase; Provisional; Region: PRK01388 266265007387 ornithine carbamoyltransferase; Validated; Region: PRK02102 266265007388 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266265007389 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266265007390 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 266265007391 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 266265007392 putative substrate binding site [chemical binding]; other site 266265007393 nucleotide binding site [chemical binding]; other site 266265007394 nucleotide binding site [chemical binding]; other site 266265007395 homodimer interface [polypeptide binding]; other site 266265007396 phasin family protein; Region: phasin; TIGR01841 266265007397 FOG: CBS domain [General function prediction only]; Region: COG0517 266265007398 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 266265007399 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266265007400 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 266265007401 NAD binding site [chemical binding]; other site 266265007402 substrate binding site [chemical binding]; other site 266265007403 catalytic Zn binding site [ion binding]; other site 266265007404 tetramer interface [polypeptide binding]; other site 266265007405 structural Zn binding site [ion binding]; other site 266265007406 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 266265007407 BON domain; Region: BON; pfam04972 266265007408 BON domain; Region: BON; pfam04972 266265007409 BON domain; Region: BON; pfam04972 266265007410 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265007411 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 266265007412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 266265007413 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266265007414 AAA domain; Region: AAA_33; pfam13671 266265007415 active site 266265007416 Ion channel; Region: Ion_trans_2; pfam07885 266265007417 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 266265007418 FMN binding site [chemical binding]; other site 266265007419 dimer interface [polypeptide binding]; other site 266265007420 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 266265007421 putative FMN binding site [chemical binding]; other site 266265007422 NADPH bind site [chemical binding]; other site 266265007423 acetyl-CoA synthetase; Provisional; Region: PRK00174 266265007424 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 266265007425 active site 266265007426 CoA binding site [chemical binding]; other site 266265007427 acyl-activating enzyme (AAE) consensus motif; other site 266265007428 AMP binding site [chemical binding]; other site 266265007429 acetate binding site [chemical binding]; other site 266265007430 Predicted membrane protein [Function unknown]; Region: COG1584 266265007431 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 266265007432 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266265007433 catalytic Zn binding site [ion binding]; other site 266265007434 structural Zn binding site [ion binding]; other site 266265007435 NAD(P) binding site [chemical binding]; other site 266265007436 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265007437 Ligand Binding Site [chemical binding]; other site 266265007438 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266265007439 Chromate transporter; Region: Chromate_transp; pfam02417 266265007440 myosin-cross-reactive antigen; Provisional; Region: PRK13977 266265007441 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266265007442 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265007443 Ligand Binding Site [chemical binding]; other site 266265007444 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265007445 Ligand Binding Site [chemical binding]; other site 266265007446 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265007447 Ligand Binding Site [chemical binding]; other site 266265007448 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265007449 Ligand Binding Site [chemical binding]; other site 266265007450 PAS domain S-box; Region: sensory_box; TIGR00229 266265007451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265007452 putative active site [active] 266265007453 heme pocket [chemical binding]; other site 266265007454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266265007455 Histidine kinase; Region: HisKA_3; pfam07730 266265007456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265007457 ATP binding site [chemical binding]; other site 266265007458 Mg2+ binding site [ion binding]; other site 266265007459 G-X-G motif; other site 266265007460 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265007461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265007462 active site 266265007463 phosphorylation site [posttranslational modification] 266265007464 intermolecular recognition site; other site 266265007465 dimerization interface [polypeptide binding]; other site 266265007466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265007467 DNA binding residues [nucleotide binding] 266265007468 dimerization interface [polypeptide binding]; other site 266265007469 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265007470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265007471 active site 266265007472 phosphorylation site [posttranslational modification] 266265007473 intermolecular recognition site; other site 266265007474 dimerization interface [polypeptide binding]; other site 266265007475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265007476 Transposase; Region: HTH_Tnp_1; pfam01527 266265007477 putative transposase OrfB; Reviewed; Region: PHA02517 266265007478 HTH-like domain; Region: HTH_21; pfam13276 266265007479 Integrase core domain; Region: rve; pfam00665 266265007480 Integrase core domain; Region: rve_3; pfam13683 266265007481 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266265007482 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 266265007483 putative NAD(P) binding site [chemical binding]; other site 266265007484 putative substrate binding site [chemical binding]; other site 266265007485 catalytic Zn binding site [ion binding]; other site 266265007486 structural Zn binding site [ion binding]; other site 266265007487 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266265007488 Cytochrome c; Region: Cytochrom_C; cl11414 266265007489 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 266265007490 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 266265007491 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 266265007492 nudix motif; other site 266265007493 thiamine pyrophosphate protein; Provisional; Region: PRK08273 266265007494 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 266265007495 PYR/PP interface [polypeptide binding]; other site 266265007496 dimer interface [polypeptide binding]; other site 266265007497 tetramer interface [polypeptide binding]; other site 266265007498 TPP binding site [chemical binding]; other site 266265007499 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265007500 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 266265007501 TPP-binding site [chemical binding]; other site 266265007502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265007503 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266265007504 putative active site [active] 266265007505 heme pocket [chemical binding]; other site 266265007506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265007507 putative active site [active] 266265007508 heme pocket [chemical binding]; other site 266265007509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265007510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265007511 dimer interface [polypeptide binding]; other site 266265007512 phosphorylation site [posttranslational modification] 266265007513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265007514 ATP binding site [chemical binding]; other site 266265007515 Mg2+ binding site [ion binding]; other site 266265007516 G-X-G motif; other site 266265007517 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265007518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265007519 active site 266265007520 phosphorylation site [posttranslational modification] 266265007521 intermolecular recognition site; other site 266265007522 dimerization interface [polypeptide binding]; other site 266265007523 Response regulator receiver domain; Region: Response_reg; pfam00072 266265007524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265007525 active site 266265007526 phosphorylation site [posttranslational modification] 266265007527 intermolecular recognition site; other site 266265007528 dimerization interface [polypeptide binding]; other site 266265007529 putative S-transferase; Provisional; Region: PRK11752 266265007530 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 266265007531 C-terminal domain interface [polypeptide binding]; other site 266265007532 GSH binding site (G-site) [chemical binding]; other site 266265007533 dimer interface [polypeptide binding]; other site 266265007534 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 266265007535 dimer interface [polypeptide binding]; other site 266265007536 N-terminal domain interface [polypeptide binding]; other site 266265007537 active site 266265007538 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 266265007539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265007540 putative substrate translocation pore; other site 266265007541 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266265007542 homotrimer interaction site [polypeptide binding]; other site 266265007543 putative active site [active] 266265007544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265007545 putative substrate translocation pore; other site 266265007546 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 266265007547 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266265007548 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266265007549 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266265007550 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265007551 catalytic loop [active] 266265007552 iron binding site [ion binding]; other site 266265007553 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 266265007554 FAD binding pocket [chemical binding]; other site 266265007555 FAD binding motif [chemical binding]; other site 266265007556 phosphate binding motif [ion binding]; other site 266265007557 beta-alpha-beta structure motif; other site 266265007558 NAD binding pocket [chemical binding]; other site 266265007559 Domain of unknown function (DUF336); Region: DUF336; pfam03928 266265007560 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265007561 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265007562 NAD(P) binding site [chemical binding]; other site 266265007563 catalytic residues [active] 266265007564 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 266265007565 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266265007566 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265007567 catalytic loop [active] 266265007568 iron binding site [ion binding]; other site 266265007569 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266265007570 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265007571 catalytic loop [active] 266265007572 iron binding site [ion binding]; other site 266265007573 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266265007574 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265007575 substrate binding pocket [chemical binding]; other site 266265007576 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265007577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266265007578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265007579 dimer interface [polypeptide binding]; other site 266265007580 putative CheW interface [polypeptide binding]; other site 266265007581 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265007582 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265007583 trimer interface [polypeptide binding]; other site 266265007584 eyelet of channel; other site 266265007585 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 266265007586 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265007587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265007588 active site 266265007589 phosphorylation site [posttranslational modification] 266265007590 intermolecular recognition site; other site 266265007591 dimerization interface [polypeptide binding]; other site 266265007592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265007593 DNA binding residues [nucleotide binding] 266265007594 dimerization interface [polypeptide binding]; other site 266265007595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265007596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265007597 dimerization interface [polypeptide binding]; other site 266265007598 Histidine kinase; Region: HisKA_3; pfam07730 266265007599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265007600 ATP binding site [chemical binding]; other site 266265007601 Mg2+ binding site [ion binding]; other site 266265007602 G-X-G motif; other site 266265007603 MltA-interacting protein MipA; Region: MipA; cl01504 266265007604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265007605 non-specific DNA binding site [nucleotide binding]; other site 266265007606 salt bridge; other site 266265007607 sequence-specific DNA binding site [nucleotide binding]; other site 266265007608 Domain of unknown function (DUF955); Region: DUF955; cl01076 266265007609 PIN domain; Region: PIN; pfam01850 266265007610 Transposase domain (DUF772); Region: DUF772; pfam05598 266265007611 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265007612 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 266265007613 Part of AAA domain; Region: AAA_19; pfam13245 266265007614 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266265007615 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 266265007616 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 266265007617 putative active site [active] 266265007618 putative metal-binding site [ion binding]; other site 266265007619 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 266265007620 Restriction endonuclease; Region: Mrr_cat; pfam04471 266265007621 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 266265007622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266265007623 Integrase core domain; Region: rve; pfam00665 266265007624 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266265007625 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266265007626 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 266265007627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265007628 Walker A motif; other site 266265007629 ATP binding site [chemical binding]; other site 266265007630 Walker B motif; other site 266265007631 arginine finger; other site 266265007632 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266265007633 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265007634 ATP binding site [chemical binding]; other site 266265007635 putative Mg++ binding site [ion binding]; other site 266265007636 helicase superfamily c-terminal domain; Region: HELICc; smart00490 266265007637 nucleotide binding region [chemical binding]; other site 266265007638 ATP-binding site [chemical binding]; other site 266265007639 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266265007640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265007641 Walker A motif; other site 266265007642 ATP binding site [chemical binding]; other site 266265007643 Walker B motif; other site 266265007644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266265007645 Integrase core domain; Region: rve; pfam00665 266265007646 transposase; Validated; Region: PRK08181 266265007647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265007648 Walker A motif; other site 266265007649 ATP binding site [chemical binding]; other site 266265007650 Integrase core domain; Region: rve; pfam00665 266265007651 Domain of unknown function (DUF932); Region: DUF932; pfam06067 266265007652 ParB-like nuclease domain; Region: ParB; smart00470 266265007653 Predicted transcriptional regulators [Transcription]; Region: COG1733 266265007654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265007655 dimerization interface [polypeptide binding]; other site 266265007656 putative DNA binding site [nucleotide binding]; other site 266265007657 putative Zn2+ binding site [ion binding]; other site 266265007658 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266265007659 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265007660 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 266265007661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265007662 S-adenosylmethionine binding site [chemical binding]; other site 266265007663 Predicted acyl esterases [General function prediction only]; Region: COG2936 266265007664 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 266265007665 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 266265007666 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265007667 putative NAD(P) binding site [chemical binding]; other site 266265007668 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 266265007669 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265007670 putative NAD(P) binding site [chemical binding]; other site 266265007671 Cupin; Region: Cupin_6; pfam12852 266265007672 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265007673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265007674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265007675 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 266265007676 SprT homologues; Region: SprT; cl01182 266265007677 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 266265007678 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266265007679 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 266265007680 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265007681 Walker A motif; other site 266265007682 ATP binding site [chemical binding]; other site 266265007683 Walker B motif; other site 266265007684 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266265007685 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266265007686 Walker A motif; other site 266265007687 hexamer interface [polypeptide binding]; other site 266265007688 ATP binding site [chemical binding]; other site 266265007689 Walker B motif; other site 266265007690 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 266265007691 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 266265007692 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266265007693 VirB7 interaction site; other site 266265007694 VirB8 protein; Region: VirB8; pfam04335 266265007695 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 266265007696 Type IV secretion system proteins; Region: T4SS; pfam07996 266265007697 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 266265007698 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 266265007699 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266265007700 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266265007701 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265007702 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265007703 catalytic residue [active] 266265007704 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 266265007705 ACT domain; Region: ACT_3; pfam10000 266265007706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 266265007707 Family description; Region: ACT_7; pfam13840 266265007708 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 266265007709 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266265007710 putative di-iron ligands [ion binding]; other site 266265007711 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 266265007712 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266265007713 Na binding site [ion binding]; other site 266265007714 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 266265007715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265007716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265007717 dimerization interface [polypeptide binding]; other site 266265007718 short chain dehydrogenase; Provisional; Region: PRK06482 266265007719 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265007720 NADP binding site [chemical binding]; other site 266265007721 active site 266265007722 steroid binding site; other site 266265007723 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266265007724 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 266265007725 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265007726 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265007727 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265007728 Response regulator receiver domain; Region: Response_reg; pfam00072 266265007729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265007730 active site 266265007731 phosphorylation site [posttranslational modification] 266265007732 intermolecular recognition site; other site 266265007733 dimerization interface [polypeptide binding]; other site 266265007734 putative transposase OrfB; Reviewed; Region: PHA02517 266265007735 Integrase core domain; Region: rve; pfam00665 266265007736 Integrase core domain; Region: rve_3; pfam13683 266265007737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265007738 Transposase; Region: HTH_Tnp_1; cl17663 266265007739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265007740 active site 266265007741 dimerization interface [polypeptide binding]; other site 266265007742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265007743 DNA binding site [nucleotide binding] 266265007744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265007745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265007746 dimerization interface [polypeptide binding]; other site 266265007747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265007748 dimer interface [polypeptide binding]; other site 266265007749 phosphorylation site [posttranslational modification] 266265007750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265007751 ATP binding site [chemical binding]; other site 266265007752 Mg2+ binding site [ion binding]; other site 266265007753 G-X-G motif; other site 266265007754 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265007755 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265007756 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 266265007757 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 266265007758 putative NAD(P) binding site [chemical binding]; other site 266265007759 active site 266265007760 Predicted transcriptional regulators [Transcription]; Region: COG1733 266265007761 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266265007762 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266265007763 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266265007764 NAD(P) binding site [chemical binding]; other site 266265007765 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265007766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265007767 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265007768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265007769 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265007770 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265007771 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265007772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265007773 HAMP domain; Region: HAMP; pfam00672 266265007774 dimerization interface [polypeptide binding]; other site 266265007775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265007776 dimer interface [polypeptide binding]; other site 266265007777 phosphorylation site [posttranslational modification] 266265007778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265007779 ATP binding site [chemical binding]; other site 266265007780 Mg2+ binding site [ion binding]; other site 266265007781 G-X-G motif; other site 266265007782 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265007783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265007784 active site 266265007785 phosphorylation site [posttranslational modification] 266265007786 intermolecular recognition site; other site 266265007787 dimerization interface [polypeptide binding]; other site 266265007788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265007789 DNA binding site [nucleotide binding] 266265007790 MltA-interacting protein MipA; Region: MipA; cl01504 266265007791 Putative cyclase; Region: Cyclase; cl00814 266265007792 Helix-turn-helix domain; Region: HTH_17; pfam12728 266265007793 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 266265007794 dimer interface [polypeptide binding]; other site 266265007795 Citrate synthase; Region: Citrate_synt; pfam00285 266265007796 active site 266265007797 oxalacetate/citrate binding site [chemical binding]; other site 266265007798 citrylCoA binding site [chemical binding]; other site 266265007799 coenzyme A binding site [chemical binding]; other site 266265007800 catalytic triad [active] 266265007801 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266265007802 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 266265007803 benzoate transport; Region: 2A0115; TIGR00895 266265007804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265007805 putative substrate translocation pore; other site 266265007806 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265007807 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265007808 trimer interface [polypeptide binding]; other site 266265007809 eyelet of channel; other site 266265007810 periplasmic protein; Provisional; Region: PRK10568 266265007811 BON domain; Region: BON; pfam04972 266265007812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265007813 Helix-turn-helix domain; Region: HTH_28; pfam13518 266265007814 putative transposase OrfB; Reviewed; Region: PHA02517 266265007815 HTH-like domain; Region: HTH_21; pfam13276 266265007816 Integrase core domain; Region: rve; pfam00665 266265007817 Integrase core domain; Region: rve_2; pfam13333 266265007818 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265007819 MarR family; Region: MarR; pfam01047 266265007820 Isochorismatase family; Region: Isochorismatase; pfam00857 266265007821 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266265007822 catalytic triad [active] 266265007823 conserved cis-peptide bond; other site 266265007824 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265007825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265007826 putative substrate translocation pore; other site 266265007827 integrase; Provisional; Region: PRK09692 266265007828 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266265007829 active site 266265007830 Int/Topo IB signature motif; other site 266265007831 GMP synthase; Reviewed; Region: guaA; PRK00074 266265007832 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 266265007833 AMP/PPi binding site [chemical binding]; other site 266265007834 candidate oxyanion hole; other site 266265007835 catalytic triad [active] 266265007836 potential glutamine specificity residues [chemical binding]; other site 266265007837 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 266265007838 ATP Binding subdomain [chemical binding]; other site 266265007839 Ligand Binding sites [chemical binding]; other site 266265007840 Dimerization subdomain; other site 266265007841 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 266265007842 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266265007843 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 266265007844 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 266265007845 active site 266265007846 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266265007847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 266265007848 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 266265007849 putative coenzyme Q binding site [chemical binding]; other site 266265007850 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 266265007851 SmpB-tmRNA interface; other site 266265007852 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266265007853 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266265007854 phosphoenolpyruvate synthase; Validated; Region: PRK06464 266265007855 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266265007856 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266265007857 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 266265007858 PEP synthetase regulatory protein; Provisional; Region: PRK05339 266265007859 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 266265007860 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 266265007861 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 266265007862 RNA/DNA hybrid binding site [nucleotide binding]; other site 266265007863 active site 266265007864 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 266265007865 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 266265007866 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 266265007867 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 266265007868 active site 266265007869 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 266265007870 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 266265007871 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 266265007872 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 266265007873 trimer interface [polypeptide binding]; other site 266265007874 active site 266265007875 UDP-GlcNAc binding site [chemical binding]; other site 266265007876 lipid binding site [chemical binding]; lipid-binding site 266265007877 periplasmic chaperone; Provisional; Region: PRK10780 266265007878 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 266265007879 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 266265007880 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266265007881 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266265007882 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266265007883 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266265007884 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 266265007885 Surface antigen; Region: Bac_surface_Ag; pfam01103 266265007886 zinc metallopeptidase RseP; Provisional; Region: PRK10779 266265007887 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266265007888 active site 266265007889 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 266265007890 protein binding site [polypeptide binding]; other site 266265007891 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 266265007892 putative substrate binding region [chemical binding]; other site 266265007893 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 266265007894 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 266265007895 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 266265007896 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 266265007897 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 266265007898 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 266265007899 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 266265007900 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 266265007901 catalytic residue [active] 266265007902 putative FPP diphosphate binding site; other site 266265007903 putative FPP binding hydrophobic cleft; other site 266265007904 dimer interface [polypeptide binding]; other site 266265007905 putative IPP diphosphate binding site; other site 266265007906 ribosome recycling factor; Reviewed; Region: frr; PRK00083 266265007907 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 266265007908 hinge region; other site 266265007909 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 266265007910 putative nucleotide binding site [chemical binding]; other site 266265007911 uridine monophosphate binding site [chemical binding]; other site 266265007912 homohexameric interface [polypeptide binding]; other site 266265007913 elongation factor Ts; Provisional; Region: tsf; PRK09377 266265007914 UBA/TS-N domain; Region: UBA; pfam00627 266265007915 Elongation factor TS; Region: EF_TS; pfam00889 266265007916 Elongation factor TS; Region: EF_TS; pfam00889 266265007917 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 266265007918 rRNA interaction site [nucleotide binding]; other site 266265007919 S8 interaction site; other site 266265007920 putative laminin-1 binding site; other site 266265007921 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266265007922 active site 266265007923 PII uridylyl-transferase; Provisional; Region: PRK03059 266265007924 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 266265007925 metal binding triad; other site 266265007926 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 266265007927 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266265007928 Zn2+ binding site [ion binding]; other site 266265007929 Mg2+ binding site [ion binding]; other site 266265007930 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 266265007931 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 266265007932 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266265007933 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266265007934 RNA binding surface [nucleotide binding]; other site 266265007935 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 266265007936 active site 266265007937 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 266265007938 active site 266265007939 catalytic residues [active] 266265007940 metal binding site [ion binding]; metal-binding site 266265007941 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 266265007942 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 266265007943 nucleotide binding pocket [chemical binding]; other site 266265007944 K-X-D-G motif; other site 266265007945 catalytic site [active] 266265007946 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 266265007947 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 266265007948 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 266265007949 Dimer interface [polypeptide binding]; other site 266265007950 BRCT sequence motif; other site 266265007951 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 266265007952 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266265007953 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266265007954 Walker A/P-loop; other site 266265007955 ATP binding site [chemical binding]; other site 266265007956 Q-loop/lid; other site 266265007957 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 266265007958 Q-loop/lid; other site 266265007959 ABC transporter signature motif; other site 266265007960 Walker B; other site 266265007961 D-loop; other site 266265007962 H-loop/switch region; other site 266265007963 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266265007964 EamA-like transporter family; Region: EamA; pfam00892 266265007965 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 266265007966 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265007967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265007968 homodimer interface [polypeptide binding]; other site 266265007969 catalytic residue [active] 266265007970 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 266265007971 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 266265007972 trimer interface [polypeptide binding]; other site 266265007973 active site 266265007974 substrate binding site [chemical binding]; other site 266265007975 CoA binding site [chemical binding]; other site 266265007976 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 266265007977 ArsC family; Region: ArsC; pfam03960 266265007978 putative catalytic residues [active] 266265007979 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 266265007980 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 266265007981 metal binding site [ion binding]; metal-binding site 266265007982 dimer interface [polypeptide binding]; other site 266265007983 HemK family putative methylases; Region: hemK_fam; TIGR00536 266265007984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265007985 S-adenosylmethionine binding site [chemical binding]; other site 266265007986 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 266265007987 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 266265007988 putative active site [active] 266265007989 catalytic site [active] 266265007990 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 266265007991 putative active site [active] 266265007992 catalytic site [active] 266265007993 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 266265007994 catalytic residues [active] 266265007995 dimer interface [polypeptide binding]; other site 266265007996 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 266265007997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265007998 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265007999 ABC transporter; Region: ABC_tran_2; pfam12848 266265008000 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265008001 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265008002 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265008003 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 266265008004 DNA repair protein RadA; Provisional; Region: PRK11823 266265008005 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 266265008006 Walker A motif/ATP binding site; other site 266265008007 ATP binding site [chemical binding]; other site 266265008008 Walker B motif; other site 266265008009 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 266265008010 alanine racemase; Reviewed; Region: alr; PRK00053 266265008011 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 266265008012 active site 266265008013 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266265008014 substrate binding site [chemical binding]; other site 266265008015 catalytic residues [active] 266265008016 dimer interface [polypeptide binding]; other site 266265008017 lysophospholipid transporter LplT; Provisional; Region: PRK11195 266265008018 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 266265008019 dimer interface [polypeptide binding]; other site 266265008020 substrate binding site [chemical binding]; other site 266265008021 ATP binding site [chemical binding]; other site 266265008022 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 266265008023 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266265008024 Fe-S cluster binding site [ion binding]; other site 266265008025 active site 266265008026 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 266265008027 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266265008028 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 266265008029 Glycoprotease family; Region: Peptidase_M22; pfam00814 266265008030 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 266265008031 acyl-CoA binding pocket [chemical binding]; other site 266265008032 CoA binding site [chemical binding]; other site 266265008033 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266265008034 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266265008035 ATP binding site [chemical binding]; other site 266265008036 Mg++ binding site [ion binding]; other site 266265008037 motif III; other site 266265008038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265008039 nucleotide binding region [chemical binding]; other site 266265008040 ATP-binding site [chemical binding]; other site 266265008041 isocitrate lyase; Provisional; Region: PRK15063 266265008042 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266265008043 tetramer interface [polypeptide binding]; other site 266265008044 active site 266265008045 Mg2+/Mn2+ binding site [ion binding]; other site 266265008046 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265008047 Ligand Binding Site [chemical binding]; other site 266265008048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265008049 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265008050 putative effector binding pocket; other site 266265008051 dimerization interface [polypeptide binding]; other site 266265008052 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266265008053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265008054 motif II; other site 266265008055 malate synthase A; Region: malate_syn_A; TIGR01344 266265008056 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 266265008057 active site 266265008058 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266265008059 putative active site pocket [active] 266265008060 dimerization interface [polypeptide binding]; other site 266265008061 putative catalytic residue [active] 266265008062 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 266265008063 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265008064 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265008065 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265008066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265008067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265008068 Coenzyme A binding pocket [chemical binding]; other site 266265008069 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 266265008070 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266265008071 HIGH motif; other site 266265008072 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 266265008073 active site 266265008074 KMSKS motif; other site 266265008075 hypothetical protein; Provisional; Region: PRK10279 266265008076 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 266265008077 nucleophile elbow; other site 266265008078 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 266265008079 NlpC/P60 family; Region: NLPC_P60; pfam00877 266265008080 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 266265008081 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265008082 Walker A/P-loop; other site 266265008083 ATP binding site [chemical binding]; other site 266265008084 Q-loop/lid; other site 266265008085 ABC transporter signature motif; other site 266265008086 Walker B; other site 266265008087 D-loop; other site 266265008088 H-loop/switch region; other site 266265008089 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266265008090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265008091 Walker A/P-loop; other site 266265008092 ATP binding site [chemical binding]; other site 266265008093 Q-loop/lid; other site 266265008094 ABC transporter signature motif; other site 266265008095 Walker B; other site 266265008096 D-loop; other site 266265008097 H-loop/switch region; other site 266265008098 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265008099 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266265008100 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 266265008101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265008102 dimer interface [polypeptide binding]; other site 266265008103 conserved gate region; other site 266265008104 putative PBP binding loops; other site 266265008105 ABC-ATPase subunit interface; other site 266265008106 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 266265008107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265008108 dimer interface [polypeptide binding]; other site 266265008109 conserved gate region; other site 266265008110 putative PBP binding loops; other site 266265008111 ABC-ATPase subunit interface; other site 266265008112 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 266265008113 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 266265008114 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 266265008115 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 266265008116 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266265008117 NAD binding site [chemical binding]; other site 266265008118 homotetramer interface [polypeptide binding]; other site 266265008119 homodimer interface [polypeptide binding]; other site 266265008120 substrate binding site [chemical binding]; other site 266265008121 active site 266265008122 Protein of unknown function (DUF796); Region: DUF796; pfam05638 266265008123 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 266265008124 aspartate kinase; Reviewed; Region: PRK06635 266265008125 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 266265008126 putative nucleotide binding site [chemical binding]; other site 266265008127 putative catalytic residues [active] 266265008128 putative Mg ion binding site [ion binding]; other site 266265008129 putative aspartate binding site [chemical binding]; other site 266265008130 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 266265008131 putative allosteric regulatory site; other site 266265008132 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 266265008133 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 266265008134 Ligand Binding Site [chemical binding]; other site 266265008135 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 266265008136 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 266265008137 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 266265008138 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 266265008139 endonuclease III; Region: ENDO3c; smart00478 266265008140 minor groove reading motif; other site 266265008141 helix-hairpin-helix signature motif; other site 266265008142 substrate binding pocket [chemical binding]; other site 266265008143 active site 266265008144 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 266265008145 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266265008146 active site 266265008147 HIGH motif; other site 266265008148 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 266265008149 KMSKS motif; other site 266265008150 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 266265008151 tRNA binding surface [nucleotide binding]; other site 266265008152 anticodon binding site; other site 266265008153 TPR repeat; Region: TPR_11; pfam13414 266265008154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265008155 binding surface 266265008156 TPR motif; other site 266265008157 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265008158 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 266265008159 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 266265008160 substrate binding site [chemical binding]; other site 266265008161 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 266265008162 substrate binding site [chemical binding]; other site 266265008163 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 266265008164 putative active site [active] 266265008165 putative metal binding site [ion binding]; other site 266265008166 serine O-acetyltransferase; Region: cysE; TIGR01172 266265008167 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266265008168 trimer interface [polypeptide binding]; other site 266265008169 active site 266265008170 substrate binding site [chemical binding]; other site 266265008171 CoA binding site [chemical binding]; other site 266265008172 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 266265008173 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 266265008174 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 266265008175 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 266265008176 active site 266265008177 dimerization interface [polypeptide binding]; other site 266265008178 lysophospholipid transporter LplT; Provisional; Region: PRK11195 266265008179 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 266265008180 MutS domain I; Region: MutS_I; pfam01624 266265008181 MutS domain II; Region: MutS_II; pfam05188 266265008182 MutS domain III; Region: MutS_III; pfam05192 266265008183 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 266265008184 Walker A/P-loop; other site 266265008185 ATP binding site [chemical binding]; other site 266265008186 Q-loop/lid; other site 266265008187 ABC transporter signature motif; other site 266265008188 Walker B; other site 266265008189 D-loop; other site 266265008190 H-loop/switch region; other site 266265008191 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 266265008192 Uncharacterized conserved protein [Function unknown]; Region: COG2850 266265008193 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265008194 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 266265008195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 266265008196 DEAD_2; Region: DEAD_2; pfam06733 266265008197 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 266265008198 transcription termination factor Rho; Provisional; Region: PRK12678 266265008199 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 266265008200 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 266265008201 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 266265008202 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 266265008203 RNA binding site [nucleotide binding]; other site 266265008204 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 266265008205 potassium uptake protein; Region: kup; TIGR00794 266265008206 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 266265008207 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265008208 active site 266265008209 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 266265008210 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 266265008211 GDP-binding site [chemical binding]; other site 266265008212 ACT binding site; other site 266265008213 IMP binding site; other site 266265008214 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 266265008215 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266265008216 dimer interface [polypeptide binding]; other site 266265008217 motif 1; other site 266265008218 active site 266265008219 motif 2; other site 266265008220 motif 3; other site 266265008221 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 266265008222 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266265008223 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 266265008224 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 266265008225 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 266265008226 HflK protein; Region: hflK; TIGR01933 266265008227 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 266265008228 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 266265008229 HflX GTPase family; Region: HflX; cd01878 266265008230 G1 box; other site 266265008231 GTP/Mg2+ binding site [chemical binding]; other site 266265008232 Switch I region; other site 266265008233 G2 box; other site 266265008234 G3 box; other site 266265008235 Switch II region; other site 266265008236 G4 box; other site 266265008237 G5 box; other site 266265008238 bacterial Hfq-like; Region: Hfq; cd01716 266265008239 hexamer interface [polypeptide binding]; other site 266265008240 Sm1 motif; other site 266265008241 RNA binding site [nucleotide binding]; other site 266265008242 Sm2 motif; other site 266265008243 GTP-binding protein Der; Reviewed; Region: PRK00093 266265008244 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 266265008245 G1 box; other site 266265008246 GTP/Mg2+ binding site [chemical binding]; other site 266265008247 Switch I region; other site 266265008248 G2 box; other site 266265008249 Switch II region; other site 266265008250 G3 box; other site 266265008251 G4 box; other site 266265008252 G5 box; other site 266265008253 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 266265008254 G1 box; other site 266265008255 GTP/Mg2+ binding site [chemical binding]; other site 266265008256 Switch I region; other site 266265008257 G2 box; other site 266265008258 G3 box; other site 266265008259 Switch II region; other site 266265008260 G4 box; other site 266265008261 G5 box; other site 266265008262 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 266265008263 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266265008264 Trp docking motif [polypeptide binding]; other site 266265008265 active site 266265008266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 266265008267 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 266265008268 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 266265008269 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 266265008270 dimer interface [polypeptide binding]; other site 266265008271 motif 1; other site 266265008272 active site 266265008273 motif 2; other site 266265008274 motif 3; other site 266265008275 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 266265008276 anticodon binding site; other site 266265008277 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 266265008278 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266265008279 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 266265008280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265008281 non-specific DNA binding site [nucleotide binding]; other site 266265008282 salt bridge; other site 266265008283 sequence-specific DNA binding site [nucleotide binding]; other site 266265008284 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 266265008285 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 266265008286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265008287 FeS/SAM binding site; other site 266265008288 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 266265008289 active site 266265008290 multimer interface [polypeptide binding]; other site 266265008291 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 266265008292 YccA-like proteins; Region: YccA_like; cd10433 266265008293 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 266265008294 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 266265008295 putative active site [active] 266265008296 putative NTP binding site [chemical binding]; other site 266265008297 putative nucleic acid binding site [nucleotide binding]; other site 266265008298 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 266265008299 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 266265008300 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 266265008301 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 266265008302 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266265008303 dihydrodipicolinate synthase; Region: dapA; TIGR00674 266265008304 dimer interface [polypeptide binding]; other site 266265008305 active site 266265008306 catalytic residue [active] 266265008307 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 266265008308 active site 266265008309 HIGH motif; other site 266265008310 dimer interface [polypeptide binding]; other site 266265008311 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266265008312 active site 266265008313 KMSKS motif; other site 266265008314 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 266265008315 Peptidase family M50; Region: Peptidase_M50; pfam02163 266265008316 active site 266265008317 putative substrate binding region [chemical binding]; other site 266265008318 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 266265008319 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 266265008320 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 266265008321 active site 266265008322 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 266265008323 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265008324 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265008325 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265008326 catalytic site [active] 266265008327 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266265008328 dinuclear metal binding motif [ion binding]; other site 266265008329 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266265008330 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 266265008331 trimer interface [polypeptide binding]; other site 266265008332 putative metal binding site [ion binding]; other site 266265008333 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 266265008334 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 266265008335 dimerization interface [polypeptide binding]; other site 266265008336 domain crossover interface; other site 266265008337 redox-dependent activation switch; other site 266265008338 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 266265008339 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 266265008340 enolase; Provisional; Region: eno; PRK00077 266265008341 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 266265008342 dimer interface [polypeptide binding]; other site 266265008343 metal binding site [ion binding]; metal-binding site 266265008344 substrate binding pocket [chemical binding]; other site 266265008345 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 266265008346 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266265008347 CTP synthetase; Validated; Region: pyrG; PRK05380 266265008348 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 266265008349 Catalytic site [active] 266265008350 active site 266265008351 UTP binding site [chemical binding]; other site 266265008352 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 266265008353 active site 266265008354 putative oxyanion hole; other site 266265008355 catalytic triad [active] 266265008356 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265008357 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265008358 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 266265008359 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 266265008360 Competence protein; Region: Competence; pfam03772 266265008361 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266265008362 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 266265008363 active site 266265008364 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 266265008365 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266265008366 Walker A/P-loop; other site 266265008367 ATP binding site [chemical binding]; other site 266265008368 Q-loop/lid; other site 266265008369 ABC transporter signature motif; other site 266265008370 Walker B; other site 266265008371 D-loop; other site 266265008372 H-loop/switch region; other site 266265008373 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 266265008374 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266265008375 FtsX-like permease family; Region: FtsX; pfam02687 266265008376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 266265008377 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 266265008378 DHH family; Region: DHH; pfam01368 266265008379 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266265008380 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 266265008381 RF-1 domain; Region: RF-1; pfam00472 266265008382 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 266265008383 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 266265008384 dimer interface [polypeptide binding]; other site 266265008385 putative anticodon binding site; other site 266265008386 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 266265008387 motif 1; other site 266265008388 active site 266265008389 motif 2; other site 266265008390 motif 3; other site 266265008391 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 266265008392 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266265008393 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265008394 catalytic loop [active] 266265008395 iron binding site [ion binding]; other site 266265008396 chaperone protein HscA; Provisional; Region: hscA; PRK05183 266265008397 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 266265008398 nucleotide binding site [chemical binding]; other site 266265008399 putative NEF/HSP70 interaction site [polypeptide binding]; other site 266265008400 SBD interface [polypeptide binding]; other site 266265008401 co-chaperone HscB; Provisional; Region: hscB; PRK03578 266265008402 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266265008403 HSP70 interaction site [polypeptide binding]; other site 266265008404 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 266265008405 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266265008406 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266265008407 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266265008408 trimerization site [polypeptide binding]; other site 266265008409 active site 266265008410 cysteine desulfurase; Provisional; Region: PRK14012 266265008411 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266265008412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265008413 catalytic residue [active] 266265008414 Predicted transcriptional regulator [Transcription]; Region: COG1959 266265008415 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 266265008416 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266265008417 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266265008418 active site 266265008419 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 266265008420 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266265008421 4Fe-4S binding domain; Region: Fer4; pfam00037 266265008422 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 266265008423 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266265008424 Cysteine-rich domain; Region: CCG; pfam02754 266265008425 Cysteine-rich domain; Region: CCG; pfam02754 266265008426 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265008427 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265008428 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265008429 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 266265008430 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 266265008431 Phasin protein; Region: Phasin_2; pfam09361 266265008432 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265008433 E3 interaction surface; other site 266265008434 lipoyl attachment site [posttranslational modification]; other site 266265008435 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 266265008436 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265008437 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266265008438 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 266265008439 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265008440 E3 interaction surface; other site 266265008441 lipoyl attachment site [posttranslational modification]; other site 266265008442 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265008443 E3 interaction surface; other site 266265008444 lipoyl attachment site [posttranslational modification]; other site 266265008445 e3 binding domain; Region: E3_binding; pfam02817 266265008446 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266265008447 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 266265008448 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266265008449 dimer interface [polypeptide binding]; other site 266265008450 TPP-binding site [chemical binding]; other site 266265008451 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 266265008452 PAS domain S-box; Region: sensory_box; TIGR00229 266265008453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265008454 putative active site [active] 266265008455 heme pocket [chemical binding]; other site 266265008456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265008457 dimer interface [polypeptide binding]; other site 266265008458 phosphorylation site [posttranslational modification] 266265008459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265008460 ATP binding site [chemical binding]; other site 266265008461 Mg2+ binding site [ion binding]; other site 266265008462 G-X-G motif; other site 266265008463 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 266265008464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265008465 active site 266265008466 phosphorylation site [posttranslational modification] 266265008467 intermolecular recognition site; other site 266265008468 dimerization interface [polypeptide binding]; other site 266265008469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265008470 DNA binding residues [nucleotide binding] 266265008471 dimerization interface [polypeptide binding]; other site 266265008472 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 266265008473 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 266265008474 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 266265008475 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 266265008476 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 266265008477 homodimer interface [polypeptide binding]; other site 266265008478 NADP binding site [chemical binding]; other site 266265008479 substrate binding site [chemical binding]; other site 266265008480 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265008481 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 266265008482 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 266265008483 active site 266265008484 Zn binding site [ion binding]; other site 266265008485 cytosine deaminase; Validated; Region: PRK07572 266265008486 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266265008487 active site 266265008488 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 266265008489 aspartate racemase; Region: asp_race; TIGR00035 266265008490 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266265008491 putative catalytic site [active] 266265008492 putative phosphate binding site [ion binding]; other site 266265008493 active site 266265008494 metal binding site A [ion binding]; metal-binding site 266265008495 DNA binding site [nucleotide binding] 266265008496 putative AP binding site [nucleotide binding]; other site 266265008497 putative metal binding site B [ion binding]; other site 266265008498 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 266265008499 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265008500 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 266265008501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265008502 active site 266265008503 phosphorylation site [posttranslational modification] 266265008504 intermolecular recognition site; other site 266265008505 dimerization interface [polypeptide binding]; other site 266265008506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265008507 Walker A motif; other site 266265008508 ATP binding site [chemical binding]; other site 266265008509 Walker B motif; other site 266265008510 arginine finger; other site 266265008511 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265008512 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266265008513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265008514 dimer interface [polypeptide binding]; other site 266265008515 phosphorylation site [posttranslational modification] 266265008516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265008517 ATP binding site [chemical binding]; other site 266265008518 Mg2+ binding site [ion binding]; other site 266265008519 G-X-G motif; other site 266265008520 glutamine synthetase; Provisional; Region: glnA; PRK09469 266265008521 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 266265008522 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266265008523 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 266265008524 active site residue [active] 266265008525 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 266265008526 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 266265008527 putative MPT binding site; other site 266265008528 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 266265008529 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266265008530 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266265008531 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 266265008532 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266265008533 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 266265008534 trimer interface [polypeptide binding]; other site 266265008535 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266265008536 trimer interface [polypeptide binding]; other site 266265008537 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 266265008538 trimer interface [polypeptide binding]; other site 266265008539 Haemagglutinin; Region: HIM; pfam05662 266265008540 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 266265008541 Haemagglutinin; Region: HIM; pfam05662 266265008542 YadA-like C-terminal region; Region: YadA; pfam03895 266265008543 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 266265008544 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265008545 ATP binding site [chemical binding]; other site 266265008546 putative Mg++ binding site [ion binding]; other site 266265008547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265008548 nucleotide binding region [chemical binding]; other site 266265008549 ATP-binding site [chemical binding]; other site 266265008550 Helicase associated domain (HA2); Region: HA2; pfam04408 266265008551 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 266265008552 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 266265008553 N-acetylglutamate synthase; Validated; Region: PRK05279 266265008554 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 266265008555 putative feedback inhibition sensing region; other site 266265008556 putative nucleotide binding site [chemical binding]; other site 266265008557 putative substrate binding site [chemical binding]; other site 266265008558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265008559 Coenzyme A binding pocket [chemical binding]; other site 266265008560 oxidative damage protection protein; Provisional; Region: PRK05408 266265008561 proline/glycine betaine transporter; Provisional; Region: PRK10642 266265008562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265008563 putative substrate translocation pore; other site 266265008564 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 266265008565 active site 266265008566 metal binding site [ion binding]; metal-binding site 266265008567 homotetramer interface [polypeptide binding]; other site 266265008568 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265008569 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 266265008570 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265008571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265008572 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 266265008573 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 266265008574 Trp docking motif [polypeptide binding]; other site 266265008575 putative active site [active] 266265008576 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265008577 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265008578 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265008579 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265008580 Walker A/P-loop; other site 266265008581 ATP binding site [chemical binding]; other site 266265008582 Q-loop/lid; other site 266265008583 ABC transporter signature motif; other site 266265008584 Walker B; other site 266265008585 D-loop; other site 266265008586 H-loop/switch region; other site 266265008587 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265008588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265008589 dimer interface [polypeptide binding]; other site 266265008590 conserved gate region; other site 266265008591 putative PBP binding loops; other site 266265008592 ABC-ATPase subunit interface; other site 266265008593 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265008594 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265008595 substrate binding pocket [chemical binding]; other site 266265008596 membrane-bound complex binding site; other site 266265008597 hinge residues; other site 266265008598 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265008599 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265008600 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265008601 Predicted integral membrane protein [Function unknown]; Region: COG3548 266265008602 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 266265008603 Cupin domain; Region: Cupin_2; cl17218 266265008604 mercuric reductase; Validated; Region: PRK06370 266265008605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265008606 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266265008607 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266265008608 GAF domain; Region: GAF; pfam01590 266265008609 PAS domain S-box; Region: sensory_box; TIGR00229 266265008610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265008611 putative active site [active] 266265008612 heme pocket [chemical binding]; other site 266265008613 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265008614 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265008615 metal binding site [ion binding]; metal-binding site 266265008616 active site 266265008617 I-site; other site 266265008618 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265008619 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 266265008620 Bacterial SH3 domain; Region: SH3_3; pfam08239 266265008621 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 266265008622 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 266265008623 nucleoside/Zn binding site; other site 266265008624 dimer interface [polypeptide binding]; other site 266265008625 catalytic motif [active] 266265008626 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266265008627 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266265008628 putative ligand binding site [chemical binding]; other site 266265008629 short chain dehydrogenase; Provisional; Region: PRK06500 266265008630 classical (c) SDRs; Region: SDR_c; cd05233 266265008631 NAD(P) binding site [chemical binding]; other site 266265008632 active site 266265008633 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 266265008634 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265008635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265008636 DNA-binding site [nucleotide binding]; DNA binding site 266265008637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265008638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265008639 homodimer interface [polypeptide binding]; other site 266265008640 catalytic residue [active] 266265008641 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 266265008642 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 266265008643 putative molybdopterin cofactor binding site [chemical binding]; other site 266265008644 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 266265008645 putative molybdopterin cofactor binding site; other site 266265008646 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 266265008647 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 266265008648 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266265008649 active sites [active] 266265008650 tetramer interface [polypeptide binding]; other site 266265008651 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 266265008652 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265008653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265008654 dimer interface [polypeptide binding]; other site 266265008655 conserved gate region; other site 266265008656 putative PBP binding loops; other site 266265008657 ABC-ATPase subunit interface; other site 266265008658 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265008659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265008660 substrate binding pocket [chemical binding]; other site 266265008661 membrane-bound complex binding site; other site 266265008662 hinge residues; other site 266265008663 DctM-like transporters; Region: DctM; pfam06808 266265008664 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 266265008665 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 266265008666 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 266265008667 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266265008668 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266265008669 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266265008670 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266265008671 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266265008672 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 266265008673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265008674 DNA-binding site [nucleotide binding]; DNA binding site 266265008675 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265008676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265008677 homodimer interface [polypeptide binding]; other site 266265008678 catalytic residue [active] 266265008679 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265008680 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265008681 trimer interface [polypeptide binding]; other site 266265008682 eyelet of channel; other site 266265008683 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265008684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265008685 DNA binding site [nucleotide binding] 266265008686 domain linker motif; other site 266265008687 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 266265008688 putative dimerization interface [polypeptide binding]; other site 266265008689 putative ligand binding site [chemical binding]; other site 266265008690 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265008691 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265008692 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266265008693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265008694 dimer interface [polypeptide binding]; other site 266265008695 conserved gate region; other site 266265008696 ABC-ATPase subunit interface; other site 266265008697 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265008698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265008699 dimer interface [polypeptide binding]; other site 266265008700 conserved gate region; other site 266265008701 putative PBP binding loops; other site 266265008702 ABC-ATPase subunit interface; other site 266265008703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265008704 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265008705 Walker A/P-loop; other site 266265008706 ATP binding site [chemical binding]; other site 266265008707 Q-loop/lid; other site 266265008708 ABC transporter signature motif; other site 266265008709 Walker B; other site 266265008710 D-loop; other site 266265008711 H-loop/switch region; other site 266265008712 TOBE domain; Region: TOBE_2; pfam08402 266265008713 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 266265008714 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266265008715 active site 266265008716 metal binding site [ion binding]; metal-binding site 266265008717 hexamer interface [polypeptide binding]; other site 266265008718 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266265008719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265008720 Response regulator receiver domain; Region: Response_reg; pfam00072 266265008721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265008722 active site 266265008723 phosphorylation site [posttranslational modification] 266265008724 intermolecular recognition site; other site 266265008725 dimerization interface [polypeptide binding]; other site 266265008726 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265008727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265008728 active site 266265008729 phosphorylation site [posttranslational modification] 266265008730 intermolecular recognition site; other site 266265008731 dimerization interface [polypeptide binding]; other site 266265008732 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265008733 DNA binding residues [nucleotide binding] 266265008734 dimerization interface [polypeptide binding]; other site 266265008735 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266265008736 Ferritin-like domain; Region: Ferritin; pfam00210 266265008737 dinuclear metal binding motif [ion binding]; other site 266265008738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266265008739 Histidine kinase; Region: HisKA_3; pfam07730 266265008740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265008741 ATP binding site [chemical binding]; other site 266265008742 Mg2+ binding site [ion binding]; other site 266265008743 G-X-G motif; other site 266265008744 Predicted small secreted protein [Function unknown]; Region: COG5510 266265008745 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 266265008746 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266265008747 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 266265008748 active site 266265008749 FMN binding site [chemical binding]; other site 266265008750 2,4-decadienoyl-CoA binding site; other site 266265008751 catalytic residue [active] 266265008752 4Fe-4S cluster binding site [ion binding]; other site 266265008753 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266265008754 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265008755 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266265008756 EamA-like transporter family; Region: EamA; pfam00892 266265008757 EamA-like transporter family; Region: EamA; pfam00892 266265008758 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 266265008759 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266265008760 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 266265008761 ThiC-associated domain; Region: ThiC-associated; pfam13667 266265008762 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 266265008763 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 266265008764 L-lactate permease; Region: Lactate_perm; cl00701 266265008765 EamA-like transporter family; Region: EamA; pfam00892 266265008766 EamA-like transporter family; Region: EamA; pfam00892 266265008767 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 266265008768 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 266265008769 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 266265008770 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 266265008771 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 266265008772 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 266265008773 Cadmium resistance transporter; Region: Cad; pfam03596 266265008774 Predicted methyltransferase [General function prediction only]; Region: COG4798 266265008775 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266265008776 2-isopropylmalate synthase; Validated; Region: PRK03739 266265008777 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 266265008778 active site 266265008779 catalytic residues [active] 266265008780 metal binding site [ion binding]; metal-binding site 266265008781 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 266265008782 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265008783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265008784 Walker A/P-loop; other site 266265008785 ATP binding site [chemical binding]; other site 266265008786 Q-loop/lid; other site 266265008787 ABC transporter signature motif; other site 266265008788 Walker B; other site 266265008789 D-loop; other site 266265008790 H-loop/switch region; other site 266265008791 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265008792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265008793 dimer interface [polypeptide binding]; other site 266265008794 conserved gate region; other site 266265008795 putative PBP binding loops; other site 266265008796 ABC-ATPase subunit interface; other site 266265008797 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265008798 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265008799 substrate binding pocket [chemical binding]; other site 266265008800 membrane-bound complex binding site; other site 266265008801 hinge residues; other site 266265008802 phenylhydantoinase; Validated; Region: PRK08323 266265008803 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266265008804 tetramer interface [polypeptide binding]; other site 266265008805 active site 266265008806 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 266265008807 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 266265008808 Na binding site [ion binding]; other site 266265008809 putative substrate binding site [chemical binding]; other site 266265008810 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 266265008811 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 266265008812 homodimer interface [polypeptide binding]; other site 266265008813 active site 266265008814 FMN binding site [chemical binding]; other site 266265008815 substrate binding site [chemical binding]; other site 266265008816 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266265008817 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 266265008818 allantoate amidohydrolase; Reviewed; Region: PRK09290 266265008819 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266265008820 active site 266265008821 metal binding site [ion binding]; metal-binding site 266265008822 dimer interface [polypeptide binding]; other site 266265008823 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266265008824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265008825 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 266265008826 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 266265008827 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 266265008828 4Fe-4S binding domain; Region: Fer4; pfam00037 266265008829 4Fe-4S binding domain; Region: Fer4; pfam00037 266265008830 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 266265008831 dimerization interface [polypeptide binding]; other site 266265008832 FAD binding pocket [chemical binding]; other site 266265008833 FAD binding motif [chemical binding]; other site 266265008834 catalytic residues [active] 266265008835 NAD binding pocket [chemical binding]; other site 266265008836 phosphate binding motif [ion binding]; other site 266265008837 beta-alpha-beta structure motif; other site 266265008838 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 266265008839 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 266265008840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265008841 substrate binding site [chemical binding]; other site 266265008842 oxyanion hole (OAH) forming residues; other site 266265008843 trimer interface [polypeptide binding]; other site 266265008844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 266265008845 substrate binding site [chemical binding]; other site 266265008846 trimer interface [polypeptide binding]; other site 266265008847 oxyanion hole (OAH) forming residues; other site 266265008848 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265008849 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265008850 non-specific DNA binding site [nucleotide binding]; other site 266265008851 salt bridge; other site 266265008852 sequence-specific DNA binding site [nucleotide binding]; other site 266265008853 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266265008854 Shikimate kinase; Region: SKI; pfam01202 266265008855 ADP binding site [chemical binding]; other site 266265008856 magnesium binding site [ion binding]; other site 266265008857 putative shikimate binding site; other site 266265008858 aldehyde dehydrogenase; Provisional; Region: PRK11903 266265008859 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 266265008860 substrate binding site [chemical binding]; other site 266265008861 dimer interface [polypeptide binding]; other site 266265008862 NADP binding site [chemical binding]; other site 266265008863 catalytic residues [active] 266265008864 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 266265008865 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 266265008866 dimer interface [polypeptide binding]; other site 266265008867 acyl-activating enzyme (AAE) consensus motif; other site 266265008868 putative active site [active] 266265008869 putative AMP binding site [chemical binding]; other site 266265008870 putative CoA binding site [chemical binding]; other site 266265008871 chemical substrate binding site [chemical binding]; other site 266265008872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265008873 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 266265008874 Phosphoesterase family; Region: Phosphoesterase; pfam04185 266265008875 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266265008876 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266265008877 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 266265008878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265008879 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266265008880 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 266265008881 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 266265008882 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265008883 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 266265008884 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 266265008885 dimerization interface [polypeptide binding]; other site 266265008886 putative ATP binding site [chemical binding]; other site 266265008887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265008888 Coenzyme A binding pocket [chemical binding]; other site 266265008889 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 266265008890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265008891 FeS/SAM binding site; other site 266265008892 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266265008893 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 266265008894 putative active site [active] 266265008895 catalytic triad [active] 266265008896 putative dimer interface [polypeptide binding]; other site 266265008897 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 266265008898 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265008899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265008900 DNA-binding site [nucleotide binding]; DNA binding site 266265008901 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265008902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265008903 homodimer interface [polypeptide binding]; other site 266265008904 catalytic residue [active] 266265008905 Cache domain; Region: Cache_1; pfam02743 266265008906 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265008907 dimerization interface [polypeptide binding]; other site 266265008908 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265008909 dimer interface [polypeptide binding]; other site 266265008910 putative CheW interface [polypeptide binding]; other site 266265008911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266265008912 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265008913 dimer interface [polypeptide binding]; other site 266265008914 putative CheW interface [polypeptide binding]; other site 266265008915 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 266265008916 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266265008917 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265008918 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 266265008919 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265008920 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 266265008921 dimer interface [polypeptide binding]; other site 266265008922 active site 266265008923 metal binding site [ion binding]; metal-binding site 266265008924 glutathione binding site [chemical binding]; other site 266265008925 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 266265008926 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265008927 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266265008928 putative DNA binding site [nucleotide binding]; other site 266265008929 putative Zn2+ binding site [ion binding]; other site 266265008930 AsnC family; Region: AsnC_trans_reg; pfam01037 266265008931 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266265008932 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 266265008933 active site 266265008934 acyl-activating enzyme (AAE) consensus motif; other site 266265008935 putative CoA binding site [chemical binding]; other site 266265008936 AMP binding site [chemical binding]; other site 266265008937 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265008938 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 266265008939 NAD(P) binding site [chemical binding]; other site 266265008940 substrate binding site [chemical binding]; other site 266265008941 homotetramer interface [polypeptide binding]; other site 266265008942 active site 266265008943 homodimer interface [polypeptide binding]; other site 266265008944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265008945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265008946 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 266265008947 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265008948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265008949 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265008950 putative effector binding pocket; other site 266265008951 dimerization interface [polypeptide binding]; other site 266265008952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265008953 substrate binding site [chemical binding]; other site 266265008954 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266265008955 oxyanion hole (OAH) forming residues; other site 266265008956 trimer interface [polypeptide binding]; other site 266265008957 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265008958 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265008959 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266265008960 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265008961 active site 266265008962 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 266265008963 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266265008964 active site 266265008965 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 266265008966 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265008967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265008968 DNA binding residues [nucleotide binding] 266265008969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265008970 S-adenosylmethionine binding site [chemical binding]; other site 266265008971 SdiA-regulated; Region: SdiA-regulated; cd09971 266265008972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 266265008973 putative active site [active] 266265008974 Bacterial Ig-like domain; Region: Big_5; pfam13205 266265008975 Bacterial Ig-like domain; Region: Big_5; pfam13205 266265008976 Lamin Tail Domain; Region: LTD; pfam00932 266265008977 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266265008978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265008979 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266265008980 putative dimerization interface [polypeptide binding]; other site 266265008981 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265008982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265008983 dimer interface [polypeptide binding]; other site 266265008984 conserved gate region; other site 266265008985 putative PBP binding loops; other site 266265008986 ABC-ATPase subunit interface; other site 266265008987 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265008988 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265008989 Walker A/P-loop; other site 266265008990 ATP binding site [chemical binding]; other site 266265008991 Q-loop/lid; other site 266265008992 ABC transporter signature motif; other site 266265008993 Walker B; other site 266265008994 D-loop; other site 266265008995 H-loop/switch region; other site 266265008996 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265008997 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265008998 active site 266265008999 non-prolyl cis peptide bond; other site 266265009000 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266265009001 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265009002 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265009003 substrate binding pocket [chemical binding]; other site 266265009004 membrane-bound complex binding site; other site 266265009005 hinge residues; other site 266265009006 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 266265009007 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266265009008 DNA binding residues [nucleotide binding] 266265009009 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266265009010 IHF dimer interface [polypeptide binding]; other site 266265009011 IHF - DNA interface [nucleotide binding]; other site 266265009012 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 266265009013 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 266265009014 putative tRNA-binding site [nucleotide binding]; other site 266265009015 B3/4 domain; Region: B3_4; pfam03483 266265009016 tRNA synthetase B5 domain; Region: B5; smart00874 266265009017 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 266265009018 dimer interface [polypeptide binding]; other site 266265009019 motif 1; other site 266265009020 motif 3; other site 266265009021 motif 2; other site 266265009022 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 266265009023 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 266265009024 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 266265009025 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 266265009026 dimer interface [polypeptide binding]; other site 266265009027 motif 1; other site 266265009028 active site 266265009029 motif 2; other site 266265009030 motif 3; other site 266265009031 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 266265009032 23S rRNA binding site [nucleotide binding]; other site 266265009033 L21 binding site [polypeptide binding]; other site 266265009034 L13 binding site [polypeptide binding]; other site 266265009035 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 266265009036 translation initiation factor IF-3; Region: infC; TIGR00168 266265009037 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 266265009038 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 266265009039 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 266265009040 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 266265009041 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266265009042 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 266265009043 active site 266265009044 dimer interface [polypeptide binding]; other site 266265009045 motif 1; other site 266265009046 motif 2; other site 266265009047 motif 3; other site 266265009048 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 266265009049 anticodon binding site; other site 266265009050 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266265009051 HD domain; Region: HD_4; pfam13328 266265009052 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266265009053 synthetase active site [active] 266265009054 NTP binding site [chemical binding]; other site 266265009055 metal binding site [ion binding]; metal-binding site 266265009056 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266265009057 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266265009058 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266265009059 homotrimer interaction site [polypeptide binding]; other site 266265009060 putative active site [active] 266265009061 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265009062 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265009063 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 266265009064 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 266265009065 PAS domain; Region: PAS_9; pfam13426 266265009066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265009067 putative active site [active] 266265009068 heme pocket [chemical binding]; other site 266265009069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265009070 DNA binding residues [nucleotide binding] 266265009071 dimerization interface [polypeptide binding]; other site 266265009072 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266265009073 active site 266265009074 short chain dehydrogenase; Provisional; Region: PRK06949 266265009075 classical (c) SDRs; Region: SDR_c; cd05233 266265009076 NAD(P) binding site [chemical binding]; other site 266265009077 active site 266265009078 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266265009079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265009080 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 266265009081 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266265009082 TPR repeat; Region: TPR_11; pfam13414 266265009083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265009084 TPR motif; other site 266265009085 binding surface 266265009086 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265009087 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 266265009088 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 266265009089 Tetramer interface [polypeptide binding]; other site 266265009090 active site 266265009091 FMN-binding site [chemical binding]; other site 266265009092 lysophospholipid transporter LplT; Provisional; Region: PRK11195 266265009093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265009094 putative substrate translocation pore; other site 266265009095 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266265009096 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266265009097 putative acyl-acceptor binding pocket; other site 266265009098 FOG: CBS domain [General function prediction only]; Region: COG0517 266265009099 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 266265009100 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 266265009101 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266265009102 homodimer interface [polypeptide binding]; other site 266265009103 substrate-cofactor binding pocket; other site 266265009104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265009105 catalytic residue [active] 266265009106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265009107 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265009108 Protein of unknown function (DUF962); Region: DUF962; cl01879 266265009109 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 266265009110 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266265009111 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265009112 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 266265009113 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265009114 FAD binding domain; Region: FAD_binding_4; pfam01565 266265009115 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 266265009116 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 266265009117 putative active site [active] 266265009118 putative metal binding site [ion binding]; other site 266265009119 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 266265009120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265009121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265009122 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265009123 putative effector binding pocket; other site 266265009124 dimerization interface [polypeptide binding]; other site 266265009125 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265009126 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266265009127 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265009128 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 266265009129 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 266265009130 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265009131 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265009132 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266265009133 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265009134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265009135 dimer interface [polypeptide binding]; other site 266265009136 putative CheW interface [polypeptide binding]; other site 266265009137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265009138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265009139 putative substrate translocation pore; other site 266265009140 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 266265009141 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265009142 acyl-activating enzyme (AAE) consensus motif; other site 266265009143 AMP binding site [chemical binding]; other site 266265009144 active site 266265009145 CoA binding site [chemical binding]; other site 266265009146 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 266265009147 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 266265009148 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 266265009149 Part of AAA domain; Region: AAA_19; pfam13245 266265009150 Family description; Region: UvrD_C_2; pfam13538 266265009151 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266265009152 DNA-binding interface [nucleotide binding]; DNA binding site 266265009153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265009154 putative Zn2+ binding site [ion binding]; other site 266265009155 Trp repressor protein; Region: Trp_repressor; cl17266 266265009156 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 266265009157 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266265009158 HIGH motif; other site 266265009159 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266265009160 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 266265009161 active site 266265009162 KMSKS motif; other site 266265009163 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 266265009164 tRNA binding surface [nucleotide binding]; other site 266265009165 anticodon binding site; other site 266265009166 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 266265009167 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266265009168 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 266265009169 active site 266265009170 tetramer interface; other site 266265009171 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 266265009172 CPxP motif; other site 266265009173 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266265009174 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266265009175 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266265009176 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266265009177 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266265009178 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266265009179 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266265009180 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265009181 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266265009182 putative active site [active] 266265009183 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 266265009184 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266265009185 putative ligand binding site [chemical binding]; other site 266265009186 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265009187 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265009188 TM-ABC transporter signature motif; other site 266265009189 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265009190 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265009191 Walker A/P-loop; other site 266265009192 ATP binding site [chemical binding]; other site 266265009193 Q-loop/lid; other site 266265009194 ABC transporter signature motif; other site 266265009195 Walker B; other site 266265009196 D-loop; other site 266265009197 H-loop/switch region; other site 266265009198 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265009199 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 266265009200 substrate binding site [chemical binding]; other site 266265009201 ATP binding site [chemical binding]; other site 266265009202 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 266265009203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 266265009204 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 266265009205 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265009206 PYR/PP interface [polypeptide binding]; other site 266265009207 dimer interface [polypeptide binding]; other site 266265009208 TPP binding site [chemical binding]; other site 266265009209 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265009210 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 266265009211 TPP-binding site; other site 266265009212 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266265009213 KduI/IolB family; Region: KduI; pfam04962 266265009214 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265009215 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265009216 Walker A/P-loop; other site 266265009217 ATP binding site [chemical binding]; other site 266265009218 Q-loop/lid; other site 266265009219 ABC transporter signature motif; other site 266265009220 Walker B; other site 266265009221 D-loop; other site 266265009222 H-loop/switch region; other site 266265009223 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265009224 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265009225 Walker A/P-loop; other site 266265009226 ATP binding site [chemical binding]; other site 266265009227 Q-loop/lid; other site 266265009228 ABC transporter signature motif; other site 266265009229 Walker B; other site 266265009230 D-loop; other site 266265009231 H-loop/switch region; other site 266265009232 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265009233 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265009234 TM-ABC transporter signature motif; other site 266265009235 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265009236 TM-ABC transporter signature motif; other site 266265009237 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266265009238 active site 266265009239 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266265009240 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 266265009241 putative active site [active] 266265009242 metal binding site [ion binding]; metal-binding site 266265009243 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 266265009244 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266265009245 nudix motif; other site 266265009246 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266265009247 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266265009248 tetramer interface [polypeptide binding]; other site 266265009249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265009250 catalytic residue [active] 266265009251 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 266265009252 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265009253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265009254 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 266265009255 putative dimerization interface [polypeptide binding]; other site 266265009256 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 266265009257 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 266265009258 motif 1; other site 266265009259 active site 266265009260 motif 2; other site 266265009261 motif 3; other site 266265009262 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266265009263 DHHA1 domain; Region: DHHA1; pfam02272 266265009264 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265009265 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265009266 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 266265009267 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266265009268 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266265009269 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 266265009270 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266265009271 active site 266265009272 HIGH motif; other site 266265009273 nucleotide binding site [chemical binding]; other site 266265009274 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 266265009275 KMSKS motif; other site 266265009276 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 266265009277 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 266265009278 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265009279 substrate binding pocket [chemical binding]; other site 266265009280 membrane-bound complex binding site; other site 266265009281 hinge residues; other site 266265009282 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 266265009283 nudix motif; other site 266265009284 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 266265009285 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 266265009286 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 266265009287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 266265009288 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 266265009289 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 266265009290 active site 266265009291 catalytic residues [active] 266265009292 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266265009293 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 266265009294 Peptidase family M23; Region: Peptidase_M23; pfam01551 266265009295 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 266265009296 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 266265009297 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266265009298 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266265009299 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 266265009300 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 266265009301 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 266265009302 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 266265009303 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 266265009304 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 266265009305 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266265009306 active site 266265009307 Int/Topo IB signature motif; other site 266265009308 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266265009309 catalytic core [active] 266265009310 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 266265009311 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 266265009312 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 266265009313 polyphosphate kinase; Provisional; Region: PRK05443 266265009314 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 266265009315 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 266265009316 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266265009317 putative active site [active] 266265009318 catalytic site [active] 266265009319 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 266265009320 putative domain interface [polypeptide binding]; other site 266265009321 putative active site [active] 266265009322 catalytic site [active] 266265009323 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266265009324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266265009325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265009326 dimer interface [polypeptide binding]; other site 266265009327 phosphorylation site [posttranslational modification] 266265009328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265009329 ATP binding site [chemical binding]; other site 266265009330 Mg2+ binding site [ion binding]; other site 266265009331 G-X-G motif; other site 266265009332 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 266265009333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265009334 active site 266265009335 phosphorylation site [posttranslational modification] 266265009336 intermolecular recognition site; other site 266265009337 dimerization interface [polypeptide binding]; other site 266265009338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265009339 DNA binding site [nucleotide binding] 266265009340 transcriptional regulator PhoU; Provisional; Region: PRK11115 266265009341 PhoU domain; Region: PhoU; pfam01895 266265009342 PhoU domain; Region: PhoU; pfam01895 266265009343 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 266265009344 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 266265009345 Walker A/P-loop; other site 266265009346 ATP binding site [chemical binding]; other site 266265009347 Q-loop/lid; other site 266265009348 ABC transporter signature motif; other site 266265009349 Walker B; other site 266265009350 D-loop; other site 266265009351 H-loop/switch region; other site 266265009352 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 266265009353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265009354 dimer interface [polypeptide binding]; other site 266265009355 conserved gate region; other site 266265009356 putative PBP binding loops; other site 266265009357 ABC-ATPase subunit interface; other site 266265009358 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 266265009359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265009360 dimer interface [polypeptide binding]; other site 266265009361 conserved gate region; other site 266265009362 putative PBP binding loops; other site 266265009363 ABC-ATPase subunit interface; other site 266265009364 PBP superfamily domain; Region: PBP_like_2; cl17296 266265009365 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 266265009366 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 266265009367 active site 266265009368 substrate binding site [chemical binding]; other site 266265009369 metal binding site [ion binding]; metal-binding site 266265009370 dihydropteroate synthase; Region: DHPS; TIGR01496 266265009371 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 266265009372 substrate binding pocket [chemical binding]; other site 266265009373 dimer interface [polypeptide binding]; other site 266265009374 inhibitor binding site; inhibition site 266265009375 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 266265009376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265009377 Walker A motif; other site 266265009378 ATP binding site [chemical binding]; other site 266265009379 Walker B motif; other site 266265009380 arginine finger; other site 266265009381 Peptidase family M41; Region: Peptidase_M41; pfam01434 266265009382 FtsJ-like methyltransferase; Region: FtsJ; cl17430 266265009383 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 266265009384 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 266265009385 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 266265009386 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 266265009387 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266265009388 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266265009389 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 266265009390 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266265009391 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266265009392 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 266265009393 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266265009394 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266265009395 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 266265009396 IMP binding site; other site 266265009397 dimer interface [polypeptide binding]; other site 266265009398 interdomain contacts; other site 266265009399 partial ornithine binding site; other site 266265009400 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 266265009401 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 266265009402 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 266265009403 catalytic site [active] 266265009404 subunit interface [polypeptide binding]; other site 266265009405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265009406 putative substrate translocation pore; other site 266265009407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265009408 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 266265009409 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265009410 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265009411 catalytic residue [active] 266265009412 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266265009413 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266265009414 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 266265009415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265009416 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 266265009417 RNA/DNA hybrid binding site [nucleotide binding]; other site 266265009418 active site 266265009419 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 266265009420 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 266265009421 active site 266265009422 catalytic site [active] 266265009423 substrate binding site [chemical binding]; other site 266265009424 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266265009425 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 266265009426 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 266265009427 Walker A/P-loop; other site 266265009428 ATP binding site [chemical binding]; other site 266265009429 Q-loop/lid; other site 266265009430 ABC transporter signature motif; other site 266265009431 Walker B; other site 266265009432 D-loop; other site 266265009433 H-loop/switch region; other site 266265009434 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 266265009435 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266265009436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265009437 putative ADP-binding pocket [chemical binding]; other site 266265009438 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 266265009439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266265009440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265009441 Walker A/P-loop; other site 266265009442 ATP binding site [chemical binding]; other site 266265009443 Q-loop/lid; other site 266265009444 ABC transporter signature motif; other site 266265009445 Walker B; other site 266265009446 D-loop; other site 266265009447 H-loop/switch region; other site 266265009448 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266265009449 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 266265009450 active site 266265009451 homotetramer interface [polypeptide binding]; other site 266265009452 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 266265009453 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 266265009454 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 266265009455 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 266265009456 Cu(I) binding site [ion binding]; other site 266265009457 Protein of unknown function (DUF461); Region: DUF461; pfam04314 266265009458 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 266265009459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266265009460 TraB family; Region: TraB; pfam01963 266265009461 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 266265009462 DNA methylase; Region: N6_N4_Mtase; cl17433 266265009463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266265009464 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 266265009465 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266265009466 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265009467 Magnesium ion binding site [ion binding]; other site 266265009468 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 266265009469 ParB-like nuclease domain; Region: ParBc; pfam02195 266265009470 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 266265009471 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 266265009472 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 266265009473 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 266265009474 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 266265009475 ssDNA binding site [nucleotide binding]; other site 266265009476 dimer interface [polypeptide binding]; other site 266265009477 tetramer (dimer of dimers) interface [polypeptide binding]; other site 266265009478 DNA topoisomerase III; Provisional; Region: PRK07726 266265009479 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 266265009480 active site 266265009481 putative interdomain interaction site [polypeptide binding]; other site 266265009482 putative metal-binding site [ion binding]; other site 266265009483 putative nucleotide binding site [chemical binding]; other site 266265009484 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 266265009485 domain I; other site 266265009486 DNA binding groove [nucleotide binding] 266265009487 phosphate binding site [ion binding]; other site 266265009488 domain II; other site 266265009489 domain III; other site 266265009490 nucleotide binding site [chemical binding]; other site 266265009491 catalytic site [active] 266265009492 domain IV; other site 266265009493 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 266265009494 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 266265009495 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 266265009496 cofactor binding site; other site 266265009497 DNA binding site [nucleotide binding] 266265009498 substrate interaction site [chemical binding]; other site 266265009499 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 266265009500 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 266265009501 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 266265009502 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 266265009503 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 266265009504 putative active site [active] 266265009505 putative NTP binding site [chemical binding]; other site 266265009506 putative nucleic acid binding site [nucleotide binding]; other site 266265009507 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 266265009508 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 266265009509 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 266265009510 Active Sites [active] 266265009511 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 266265009512 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 266265009513 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 266265009514 Methyltransferase domain; Region: Methyltransf_26; pfam13659 266265009515 S-adenosylmethionine binding site [chemical binding]; other site 266265009516 DEAD-like helicases superfamily; Region: DEXDc; smart00487 266265009517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265009518 nucleotide binding region [chemical binding]; other site 266265009519 ATP-binding site [chemical binding]; other site 266265009520 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 266265009521 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 266265009522 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265009523 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265009524 catalytic residue [active] 266265009525 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 266265009526 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 266265009527 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 266265009528 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 266265009529 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 266265009530 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 266265009531 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 266265009532 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 266265009533 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 266265009534 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 266265009535 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 266265009536 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 266265009537 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 266265009538 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 266265009539 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 266265009540 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 266265009541 catalytic residues [active] 266265009542 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266265009543 MPN+ (JAMM) motif; other site 266265009544 Zinc-binding site [ion binding]; other site 266265009545 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 266265009546 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 266265009547 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 266265009548 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 266265009549 Protein of unknown function (DUF3742); Region: DUF3742; pfam12553 266265009550 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 266265009551 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 266265009552 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 266265009553 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 266265009554 Putative helicase; Region: TraI_2; pfam07514 266265009555 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 266265009556 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265009557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265009558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265009559 cyanate transporter; Region: CynX; TIGR00896 266265009560 putative substrate translocation pore; other site 266265009561 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 266265009562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265009563 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265009564 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265009565 acyl-activating enzyme (AAE) consensus motif; other site 266265009566 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 266265009567 AMP binding site [chemical binding]; other site 266265009568 active site 266265009569 acyl-activating enzyme (AAE) consensus motif; other site 266265009570 CoA binding site [chemical binding]; other site 266265009571 AMP-binding enzyme; Region: AMP-binding; pfam00501 266265009572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265009573 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265009574 active site 266265009575 CoA binding site [chemical binding]; other site 266265009576 AMP binding site [chemical binding]; other site 266265009577 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 266265009578 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266265009579 putative active site [active] 266265009580 catalytic triad [active] 266265009581 putative dimer interface [polypeptide binding]; other site 266265009582 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266265009583 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 266265009584 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266265009585 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 266265009586 active site 266265009587 nucleophile elbow; other site 266265009588 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 266265009589 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 266265009590 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 266265009591 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265009592 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265009593 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265009594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265009595 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265009596 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266265009597 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265009598 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 266265009599 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 266265009600 active site 266265009601 catalytic residues [active] 266265009602 metal binding site [ion binding]; metal-binding site 266265009603 DmpG-like communication domain; Region: DmpG_comm; pfam07836 266265009604 acetaldehyde dehydrogenase; Validated; Region: PRK08300 266265009605 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266265009606 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 266265009607 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265009608 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265009609 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266265009610 homotrimer interaction site [polypeptide binding]; other site 266265009611 putative active site [active] 266265009612 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 266265009613 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 266265009614 NAD binding site [chemical binding]; other site 266265009615 catalytic residues [active] 266265009616 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 266265009617 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 266265009618 active site 266265009619 metal binding site [ion binding]; metal-binding site 266265009620 The beta subunit of the Class III extradiol dioxygenase, 2-amino-5-chlorophenol 1,6-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of 2-amino-5-chlorophenol; Region: 2A5CPDO_B; cd07372 266265009621 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 266265009622 putative active site [active] 266265009623 putative metal binding site [ion binding]; other site 266265009624 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266265009625 homotrimer interaction site [polypeptide binding]; other site 266265009626 putative active site [active] 266265009627 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265009628 MarR family; Region: MarR_2; pfam12802 266265009629 Predicted membrane protein [Function unknown]; Region: COG2259 266265009630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265009631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265009632 DoxX; Region: DoxX; cl17842 266265009633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265009634 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266265009635 NAD(P) binding site [chemical binding]; other site 266265009636 active site 266265009637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265009638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265009639 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266265009640 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265009641 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266265009642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265009643 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266265009644 dimerization interface [polypeptide binding]; other site 266265009645 substrate binding pocket [chemical binding]; other site 266265009646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265009647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265009648 non-specific DNA binding site [nucleotide binding]; other site 266265009649 salt bridge; other site 266265009650 sequence-specific DNA binding site [nucleotide binding]; other site 266265009651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265009652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265009653 dimerization interface [polypeptide binding]; other site 266265009654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265009655 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266265009656 The C-terminal substrate binding domain of LysR-type transcriptional regulator ClcR involved in the chlorocatechol catabolism, contains type 2 periplasmic binding fold; Region: PBP2_ClcR; cd08485 266265009657 putative dimerization interface [polypeptide binding]; other site 266265009658 putative substrate binding pocket [chemical binding]; other site 266265009659 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462 266265009660 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 266265009661 dimer interface [polypeptide binding]; other site 266265009662 active site 266265009663 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 266265009664 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 266265009665 octamer interface [polypeptide binding]; other site 266265009666 active site 266265009667 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265009668 Dienelactone hydrolase family; Region: DLH; pfam01738 266265009669 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 266265009670 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 266265009671 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 266265009672 active site 266265009673 dimer interface [polypeptide binding]; other site 266265009674 metal binding site [ion binding]; metal-binding site 266265009675 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265009676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266265009677 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266265009678 Winged helix-turn helix; Region: HTH_29; pfam13551 266265009679 Integrase core domain; Region: rve; pfam00665 266265009680 AAA domain; Region: AAA_22; pfam13401 266265009681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265009682 Walker A motif; other site 266265009683 ATP binding site [chemical binding]; other site 266265009684 Walker B motif; other site 266265009685 arginine finger; other site 266265009686 lipoprotein signal peptidase; Provisional; Region: PRK14776 266265009687 Heavy-metal-associated domain; Region: HMA; pfam00403 266265009688 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265009689 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266265009690 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266265009691 DNA binding residues [nucleotide binding] 266265009692 dimer interface [polypeptide binding]; other site 266265009693 putative metal binding site [ion binding]; other site 266265009694 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265009695 NMT1/THI5 like; Region: NMT1; pfam09084 266265009696 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265009697 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265009698 NIPSNAP; Region: NIPSNAP; pfam07978 266265009699 N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins; Region: MhqB_like_N; cd08344 266265009700 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 266265009701 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265009702 putative active site [active] 266265009703 putative metal binding site [ion binding]; other site 266265009704 YCII-related domain; Region: YCII; pfam03795 266265009705 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265009706 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265009707 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265009708 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266265009709 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265009710 putative DNA binding site [nucleotide binding]; other site 266265009711 putative Zn2+ binding site [ion binding]; other site 266265009712 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265009713 inter-subunit interface; other site 266265009714 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265009715 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 266265009716 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 266265009717 putative alpha subunit interface [polypeptide binding]; other site 266265009718 putative active site [active] 266265009719 putative substrate binding site [chemical binding]; other site 266265009720 Fe binding site [ion binding]; other site 266265009721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266265009722 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266265009723 lipoprotein signal peptidase; Provisional; Region: PRK14776 266265009724 Heavy-metal-associated domain; Region: HMA; pfam00403 266265009725 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265009726 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266265009727 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266265009728 DNA binding residues [nucleotide binding] 266265009729 dimer interface [polypeptide binding]; other site 266265009730 putative metal binding site [ion binding]; other site 266265009731 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265009732 iron-sulfur cluster [ion binding]; other site 266265009733 [2Fe-2S] cluster binding site [ion binding]; other site 266265009734 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 266265009735 putative alpha subunit interface [polypeptide binding]; other site 266265009736 putative active site [active] 266265009737 putative substrate binding site [chemical binding]; other site 266265009738 Fe binding site [ion binding]; other site 266265009739 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265009740 inter-subunit interface; other site 266265009741 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265009742 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266265009743 FMN-binding pocket [chemical binding]; other site 266265009744 flavin binding motif; other site 266265009745 phosphate binding motif [ion binding]; other site 266265009746 beta-alpha-beta structure motif; other site 266265009747 NAD binding pocket [chemical binding]; other site 266265009748 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265009749 catalytic loop [active] 266265009750 iron binding site [ion binding]; other site 266265009751 benzoate transport; Region: 2A0115; TIGR00895 266265009752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265009753 putative substrate translocation pore; other site 266265009754 YCII-related domain; Region: YCII; cl00999 266265009755 integrase; Provisional; Region: PRK09692 266265009756 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266265009757 active site 266265009758 Int/Topo IB signature motif; other site 266265009759 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 266265009760 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 266265009761 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266265009762 GIY-YIG motif/motif A; other site 266265009763 active site 266265009764 catalytic site [active] 266265009765 putative DNA binding site [nucleotide binding]; other site 266265009766 metal binding site [ion binding]; metal-binding site 266265009767 UvrB/uvrC motif; Region: UVR; pfam02151 266265009768 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 266265009769 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 266265009770 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 266265009771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 266265009772 elongation factor P; Validated; Region: PRK00529 266265009773 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 266265009774 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 266265009775 RNA binding site [nucleotide binding]; other site 266265009776 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 266265009777 RNA binding site [nucleotide binding]; other site 266265009778 CsbD-like; Region: CsbD; cl17424 266265009779 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266265009780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265009781 active site 266265009782 phosphorylation site [posttranslational modification] 266265009783 intermolecular recognition site; other site 266265009784 dimerization interface [polypeptide binding]; other site 266265009785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265009786 Walker A motif; other site 266265009787 ATP binding site [chemical binding]; other site 266265009788 Walker B motif; other site 266265009789 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265009790 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 266265009791 beta-hexosaminidase; Provisional; Region: PRK05337 266265009792 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 266265009793 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 266265009794 active site 266265009795 hydrophilic channel; other site 266265009796 dimerization interface [polypeptide binding]; other site 266265009797 catalytic residues [active] 266265009798 active site lid [active] 266265009799 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 266265009800 Recombination protein O N terminal; Region: RecO_N; pfam11967 266265009801 Recombination protein O C terminal; Region: RecO_C; pfam02565 266265009802 GTPase Era; Reviewed; Region: era; PRK00089 266265009803 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 266265009804 G1 box; other site 266265009805 GTP/Mg2+ binding site [chemical binding]; other site 266265009806 Switch I region; other site 266265009807 G2 box; other site 266265009808 Switch II region; other site 266265009809 G3 box; other site 266265009810 G4 box; other site 266265009811 G5 box; other site 266265009812 KH domain; Region: KH_2; pfam07650 266265009813 ribonuclease III; Reviewed; Region: PRK12372 266265009814 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 266265009815 dimerization interface [polypeptide binding]; other site 266265009816 active site 266265009817 metal binding site [ion binding]; metal-binding site 266265009818 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 266265009819 signal peptidase I; Provisional; Region: PRK10861 266265009820 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266265009821 Catalytic site [active] 266265009822 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 266265009823 GTP-binding protein LepA; Provisional; Region: PRK05433 266265009824 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 266265009825 G1 box; other site 266265009826 putative GEF interaction site [polypeptide binding]; other site 266265009827 GTP/Mg2+ binding site [chemical binding]; other site 266265009828 Switch I region; other site 266265009829 G2 box; other site 266265009830 G3 box; other site 266265009831 Switch II region; other site 266265009832 G4 box; other site 266265009833 G5 box; other site 266265009834 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 266265009835 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 266265009836 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 266265009837 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 266265009838 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266265009839 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266265009840 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266265009841 protein binding site [polypeptide binding]; other site 266265009842 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266265009843 protein binding site [polypeptide binding]; other site 266265009844 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 266265009845 anti-sigma E factor; Provisional; Region: rseB; PRK09455 266265009846 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 266265009847 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 266265009848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265009849 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265009850 DNA binding residues [nucleotide binding] 266265009851 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 266265009852 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266265009853 dimer interface [polypeptide binding]; other site 266265009854 active site 266265009855 acyl carrier protein; Provisional; Region: acpP; PRK00982 266265009856 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266265009857 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 266265009858 NAD(P) binding site [chemical binding]; other site 266265009859 homotetramer interface [polypeptide binding]; other site 266265009860 homodimer interface [polypeptide binding]; other site 266265009861 active site 266265009862 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 266265009863 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 266265009864 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266265009865 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266265009866 dimer interface [polypeptide binding]; other site 266265009867 active site 266265009868 CoA binding pocket [chemical binding]; other site 266265009869 putative phosphate acyltransferase; Provisional; Region: PRK05331 266265009870 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 266265009871 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 266265009872 Maf-like protein; Region: Maf; pfam02545 266265009873 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 266265009874 active site 266265009875 dimer interface [polypeptide binding]; other site 266265009876 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 266265009877 putative SAM binding site [chemical binding]; other site 266265009878 homodimer interface [polypeptide binding]; other site 266265009879 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 266265009880 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 266265009881 tandem repeat interface [polypeptide binding]; other site 266265009882 oligomer interface [polypeptide binding]; other site 266265009883 active site residues [active] 266265009884 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 266265009885 iron-sulfur cluster [ion binding]; other site 266265009886 [2Fe-2S] cluster binding site [ion binding]; other site 266265009887 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266265009888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265009889 motif II; other site 266265009890 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 266265009891 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266265009892 RNA binding surface [nucleotide binding]; other site 266265009893 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 266265009894 active site 266265009895 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 266265009896 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 266265009897 homodimer interface [polypeptide binding]; other site 266265009898 oligonucleotide binding site [chemical binding]; other site 266265009899 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 266265009900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265009901 FeS/SAM binding site; other site 266265009902 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 266265009903 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 266265009904 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 266265009905 GTP binding site; other site 266265009906 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 266265009907 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 266265009908 dimer interface [polypeptide binding]; other site 266265009909 putative functional site; other site 266265009910 putative MPT binding site; other site 266265009911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265009912 Coenzyme A binding pocket [chemical binding]; other site 266265009913 RmuC family; Region: RmuC; pfam02646 266265009914 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266265009915 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 266265009916 dimerization interface [polypeptide binding]; other site 266265009917 ligand binding site [chemical binding]; other site 266265009918 NADP binding site [chemical binding]; other site 266265009919 catalytic site [active] 266265009920 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266265009921 Uncharacterized conserved protein [Function unknown]; Region: COG1556 266265009922 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 266265009923 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 266265009924 active site 266265009925 Ferredoxin [Energy production and conversion]; Region: COG1146 266265009926 4Fe-4S binding domain; Region: Fer4; cl02805 266265009927 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 266265009928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 266265009929 CreA protein; Region: CreA; pfam05981 266265009930 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265009931 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265009932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265009933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265009934 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 266265009935 Predicted membrane protein [Function unknown]; Region: COG4392 266265009936 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 266265009937 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 266265009938 Part of AAA domain; Region: AAA_19; pfam13245 266265009939 Family description; Region: UvrD_C_2; pfam13538 266265009940 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266265009941 RNA binding surface [nucleotide binding]; other site 266265009942 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 266265009943 multidrug efflux protein; Reviewed; Region: PRK01766 266265009944 cation binding site [ion binding]; other site 266265009945 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 266265009946 Sodium Bile acid symporter family; Region: SBF; pfam01758 266265009947 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 266265009948 putative active site [active] 266265009949 catalytic site [active] 266265009950 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 266265009951 PLD-like domain; Region: PLDc_2; pfam13091 266265009952 putative active site [active] 266265009953 catalytic site [active] 266265009954 fumarate hydratase; Reviewed; Region: fumC; PRK00485 266265009955 Class II fumarases; Region: Fumarase_classII; cd01362 266265009956 active site 266265009957 tetramer interface [polypeptide binding]; other site 266265009958 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266265009959 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266265009960 conserved cys residue [active] 266265009961 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265009962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265009963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265009964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265009965 putative substrate translocation pore; other site 266265009966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265009967 dimerization interface [polypeptide binding]; other site 266265009968 putative DNA binding site [nucleotide binding]; other site 266265009969 putative Zn2+ binding site [ion binding]; other site 266265009970 thymidylate synthase; Provisional; Region: thyA; PRK13821 266265009971 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 266265009972 dimerization interface [polypeptide binding]; other site 266265009973 active site 266265009974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265009975 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266265009976 Walker A motif; other site 266265009977 ATP binding site [chemical binding]; other site 266265009978 Walker B motif; other site 266265009979 arginine finger; other site 266265009980 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 266265009981 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 266265009982 putative active site [active] 266265009983 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 266265009984 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266265009985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265009986 Walker A motif; other site 266265009987 ATP binding site [chemical binding]; other site 266265009988 Walker B motif; other site 266265009989 arginine finger; other site 266265009990 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266265009991 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 266265009992 folate binding site [chemical binding]; other site 266265009993 NADP+ binding site [chemical binding]; other site 266265009994 peptidase PmbA; Provisional; Region: PRK11040 266265009995 hypothetical protein; Provisional; Region: PRK05255 266265009996 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 266265009997 MPT binding site; other site 266265009998 trimer interface [polypeptide binding]; other site 266265009999 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 266265010000 catalytic site [active] 266265010001 putative active site [active] 266265010002 putative substrate binding site [chemical binding]; other site 266265010003 dimer interface [polypeptide binding]; other site 266265010004 Peptidase family M48; Region: Peptidase_M48; pfam01435 266265010005 GTPase RsgA; Reviewed; Region: PRK00098 266265010006 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 266265010007 RNA binding site [nucleotide binding]; other site 266265010008 homodimer interface [polypeptide binding]; other site 266265010009 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 266265010010 GTPase/Zn-binding domain interface [polypeptide binding]; other site 266265010011 GTP/Mg2+ binding site [chemical binding]; other site 266265010012 G4 box; other site 266265010013 G5 box; other site 266265010014 G1 box; other site 266265010015 Switch I region; other site 266265010016 G2 box; other site 266265010017 G3 box; other site 266265010018 Switch II region; other site 266265010019 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 266265010020 Transposase domain (DUF772); Region: DUF772; pfam05598 266265010021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265010022 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 266265010023 CobD/CbiB family protein; Provisional; Region: PRK07630 266265010024 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 266265010025 putative active site [active] 266265010026 putative CoA binding site [chemical binding]; other site 266265010027 nudix motif; other site 266265010028 metal binding site [ion binding]; metal-binding site 266265010029 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 266265010030 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 266265010031 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 266265010032 RimM N-terminal domain; Region: RimM; pfam01782 266265010033 PRC-barrel domain; Region: PRC; pfam05239 266265010034 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 266265010035 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 266265010036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 266265010037 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 266265010038 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265010039 FeS/SAM binding site; other site 266265010040 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 266265010041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265010042 putative DNA binding site [nucleotide binding]; other site 266265010043 putative Zn2+ binding site [ion binding]; other site 266265010044 AsnC family; Region: AsnC_trans_reg; pfam01037 266265010045 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266265010046 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266265010047 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266265010048 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265010049 active site 266265010050 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266265010051 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266265010052 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266265010053 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266265010054 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266265010055 Ligand binding site [chemical binding]; other site 266265010056 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266265010057 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266265010058 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266265010059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265010060 ABC-ATPase subunit interface; other site 266265010061 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 266265010062 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 266265010063 Walker A/P-loop; other site 266265010064 ATP binding site [chemical binding]; other site 266265010065 Q-loop/lid; other site 266265010066 ABC transporter signature motif; other site 266265010067 Walker B; other site 266265010068 D-loop; other site 266265010069 H-loop/switch region; other site 266265010070 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 266265010071 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 266265010072 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265010073 enoyl-CoA hydratase; Validated; Region: PRK08139 266265010074 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265010075 substrate binding site [chemical binding]; other site 266265010076 oxyanion hole (OAH) forming residues; other site 266265010077 trimer interface [polypeptide binding]; other site 266265010078 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266265010079 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 266265010080 putative active site [active] 266265010081 Zn binding site [ion binding]; other site 266265010082 Transglycosylase SLT domain; Region: SLT_2; pfam13406 266265010083 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265010084 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265010085 cysteine synthase B; Region: cysM; TIGR01138 266265010086 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266265010087 dimer interface [polypeptide binding]; other site 266265010088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265010089 catalytic residue [active] 266265010090 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 266265010091 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 266265010092 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 266265010093 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 266265010094 NADP binding site [chemical binding]; other site 266265010095 homopentamer interface [polypeptide binding]; other site 266265010096 substrate binding site [chemical binding]; other site 266265010097 active site 266265010098 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 266265010099 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265010100 putative ribose interaction site [chemical binding]; other site 266265010101 putative ADP binding site [chemical binding]; other site 266265010102 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266265010103 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266265010104 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266265010105 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 266265010106 tetratricopeptide repeat protein; Provisional; Region: PRK11788 266265010107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265010108 binding surface 266265010109 TPR motif; other site 266265010110 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266265010111 IHF dimer interface [polypeptide binding]; other site 266265010112 IHF - DNA interface [nucleotide binding]; other site 266265010113 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 266265010114 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 266265010115 RNA binding site [nucleotide binding]; other site 266265010116 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 266265010117 RNA binding site [nucleotide binding]; other site 266265010118 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 266265010119 RNA binding site [nucleotide binding]; other site 266265010120 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 266265010121 RNA binding site [nucleotide binding]; other site 266265010122 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 266265010123 RNA binding site [nucleotide binding]; other site 266265010124 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 266265010125 RNA binding site [nucleotide binding]; other site 266265010126 cytidylate kinase; Provisional; Region: cmk; PRK00023 266265010127 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 266265010128 CMP-binding site; other site 266265010129 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 266265010130 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 266265010131 hinge; other site 266265010132 active site 266265010133 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 266265010134 prephenate dehydrogenase; Validated; Region: PRK08507 266265010135 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 266265010136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265010137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265010138 homodimer interface [polypeptide binding]; other site 266265010139 catalytic residue [active] 266265010140 Chorismate mutase type II; Region: CM_2; smart00830 266265010141 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 266265010142 Prephenate dehydratase; Region: PDT; pfam00800 266265010143 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 266265010144 putative L-Phe binding site [chemical binding]; other site 266265010145 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 266265010146 homodimer interface [polypeptide binding]; other site 266265010147 substrate-cofactor binding pocket; other site 266265010148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265010149 catalytic residue [active] 266265010150 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 266265010151 DNA gyrase subunit A; Validated; Region: PRK05560 266265010152 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 266265010153 CAP-like domain; other site 266265010154 active site 266265010155 primary dimer interface [polypeptide binding]; other site 266265010156 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266265010157 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266265010158 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266265010159 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266265010160 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266265010161 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 266265010162 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265010163 ligand binding site [chemical binding]; other site 266265010164 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 266265010165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265010166 S-adenosylmethionine binding site [chemical binding]; other site 266265010167 phosphoglycolate phosphatase; Provisional; Region: PRK13222 266265010168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265010169 motif II; other site 266265010170 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266265010171 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 266265010172 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265010173 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 266265010174 PBP superfamily domain; Region: PBP_like; pfam12727 266265010175 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 266265010176 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 266265010177 putative dimer interface [polypeptide binding]; other site 266265010178 [2Fe-2S] cluster binding site [ion binding]; other site 266265010179 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 266265010180 putative dimer interface [polypeptide binding]; other site 266265010181 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 266265010182 SLBB domain; Region: SLBB; pfam10531 266265010183 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 266265010184 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265010185 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 266265010186 catalytic loop [active] 266265010187 iron binding site [ion binding]; other site 266265010188 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 266265010189 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266265010190 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 266265010191 [4Fe-4S] binding site [ion binding]; other site 266265010192 molybdopterin cofactor binding site; other site 266265010193 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 266265010194 molybdopterin cofactor binding site; other site 266265010195 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 266265010196 FAD binding domain; Region: FAD_binding_3; pfam01494 266265010197 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265010198 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265010199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265010200 dimerization interface [polypeptide binding]; other site 266265010201 putative DNA binding site [nucleotide binding]; other site 266265010202 putative Zn2+ binding site [ion binding]; other site 266265010203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265010204 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 266265010205 TPR motif; other site 266265010206 binding surface 266265010207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265010208 binding surface 266265010209 TPR motif; other site 266265010210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265010211 binding surface 266265010212 TPR motif; other site 266265010213 TPR repeat; Region: TPR_11; pfam13414 266265010214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265010215 citrate-proton symporter; Provisional; Region: PRK15075 266265010216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265010217 putative substrate translocation pore; other site 266265010218 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266265010219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265010220 Coenzyme A binding pocket [chemical binding]; other site 266265010221 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 266265010222 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266265010223 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 266265010224 catalytic triad [active] 266265010225 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 266265010226 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266265010227 amidase; Provisional; Region: PRK07056 266265010228 Amidase; Region: Amidase; cl11426 266265010229 disulfide bond formation protein B; Provisional; Region: PRK02110 266265010230 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 266265010231 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265010232 catalytic loop [active] 266265010233 iron binding site [ion binding]; other site 266265010234 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265010235 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266265010236 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 266265010237 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265010238 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265010239 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266265010240 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 266265010241 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266265010242 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 266265010243 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 266265010244 active site 266265010245 purine riboside binding site [chemical binding]; other site 266265010246 guanine deaminase; Provisional; Region: PRK09228 266265010247 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 266265010248 active site 266265010249 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266265010250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265010251 S-adenosylmethionine binding site [chemical binding]; other site 266265010252 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 266265010253 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 266265010254 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266265010255 dimer interface [polypeptide binding]; other site 266265010256 active site 266265010257 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 266265010258 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266265010259 dimer interface [polypeptide binding]; other site 266265010260 active site 266265010261 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266265010262 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 266265010263 NAD(P) binding site [chemical binding]; other site 266265010264 homotetramer interface [polypeptide binding]; other site 266265010265 homodimer interface [polypeptide binding]; other site 266265010266 active site 266265010267 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 266265010268 putative active site 1 [active] 266265010269 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 266265010270 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 266265010271 dimer interface [polypeptide binding]; other site 266265010272 active site 266265010273 Predicted exporter [General function prediction only]; Region: COG4258 266265010274 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 266265010275 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266265010276 active site 266265010277 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266265010278 active sites [active] 266265010279 tetramer interface [polypeptide binding]; other site 266265010280 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266265010281 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 266265010282 Ligand binding site; other site 266265010283 Putative Catalytic site; other site 266265010284 DXD motif; other site 266265010285 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266265010286 putative acyl-acceptor binding pocket; other site 266265010287 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 266265010288 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265010289 AMP binding site [chemical binding]; other site 266265010290 active site 266265010291 acyl-activating enzyme (AAE) consensus motif; other site 266265010292 CoA binding site [chemical binding]; other site 266265010293 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 266265010294 active site 2 [active] 266265010295 dimer interface [polypeptide binding]; other site 266265010296 active site 1 [active] 266265010297 Predicted membrane protein [Function unknown]; Region: COG4648 266265010298 acyl carrier protein; Provisional; Region: PRK05350 266265010299 Phosphopantetheine attachment site; Region: PP-binding; cl09936 266265010300 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266265010301 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266265010302 putative acyl-acceptor binding pocket; other site 266265010303 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 266265010304 Predicted membrane protein [Function unknown]; Region: COG2119 266265010305 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 266265010306 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 266265010307 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 266265010308 aminopeptidase N; Provisional; Region: pepN; PRK14015 266265010309 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 266265010310 active site 266265010311 Zn binding site [ion binding]; other site 266265010312 addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607 266265010313 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 266265010314 non-specific DNA binding site [nucleotide binding]; other site 266265010315 salt bridge; other site 266265010316 sequence-specific DNA binding site [nucleotide binding]; other site 266265010317 fructose-1,6-bisphosphatase family protein; Region: PLN02628 266265010318 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 266265010319 AMP binding site [chemical binding]; other site 266265010320 metal binding site [ion binding]; metal-binding site 266265010321 active site 266265010322 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266265010323 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 266265010324 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 266265010325 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 266265010326 chorismate mutase; Provisional; Region: PRK09269 266265010327 Chorismate mutase type II; Region: CM_2; cl00693 266265010328 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 266265010329 active site 266265010330 catalytic site [active] 266265010331 substrate binding site [chemical binding]; other site 266265010332 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 266265010333 GIY-YIG motif/motif A; other site 266265010334 active site 266265010335 catalytic site [active] 266265010336 putative DNA binding site [nucleotide binding]; other site 266265010337 metal binding site [ion binding]; metal-binding site 266265010338 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266265010339 DNA-binding site [nucleotide binding]; DNA binding site 266265010340 RNA-binding motif; other site 266265010341 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265010342 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265010343 trimer interface [polypeptide binding]; other site 266265010344 eyelet of channel; other site 266265010345 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 266265010346 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 266265010347 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 266265010348 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 266265010349 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 266265010350 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266265010351 Zn2+ binding site [ion binding]; other site 266265010352 Mg2+ binding site [ion binding]; other site 266265010353 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 266265010354 synthetase active site [active] 266265010355 NTP binding site [chemical binding]; other site 266265010356 metal binding site [ion binding]; metal-binding site 266265010357 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 266265010358 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 266265010359 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 266265010360 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 266265010361 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 266265010362 catalytic site [active] 266265010363 G-X2-G-X-G-K; other site 266265010364 hypothetical protein; Provisional; Region: PRK11820 266265010365 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 266265010366 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 266265010367 ribonuclease PH; Reviewed; Region: rph; PRK00173 266265010368 Ribonuclease PH; Region: RNase_PH_bact; cd11362 266265010369 hexamer interface [polypeptide binding]; other site 266265010370 active site 266265010371 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 266265010372 active site 266265010373 dimerization interface [polypeptide binding]; other site 266265010374 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 266265010375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265010376 FeS/SAM binding site; other site 266265010377 HemN C-terminal domain; Region: HemN_C; pfam06969 266265010378 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266265010379 homotrimer interaction site [polypeptide binding]; other site 266265010380 putative active site [active] 266265010381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265010382 putative substrate translocation pore; other site 266265010383 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 266265010384 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265010385 inhibitor-cofactor binding pocket; inhibition site 266265010386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265010387 catalytic residue [active] 266265010388 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 266265010389 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 266265010390 catalytic motif [active] 266265010391 Zn binding site [ion binding]; other site 266265010392 RibD C-terminal domain; Region: RibD_C; cl17279 266265010393 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 266265010394 Lumazine binding domain; Region: Lum_binding; pfam00677 266265010395 Lumazine binding domain; Region: Lum_binding; pfam00677 266265010396 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 266265010397 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 266265010398 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 266265010399 dimerization interface [polypeptide binding]; other site 266265010400 active site 266265010401 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 266265010402 homopentamer interface [polypeptide binding]; other site 266265010403 active site 266265010404 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 266265010405 putative RNA binding site [nucleotide binding]; other site 266265010406 aminotransferase; Validated; Region: PRK07337 266265010407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265010408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265010409 homodimer interface [polypeptide binding]; other site 266265010410 catalytic residue [active] 266265010411 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266265010412 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265010413 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265010414 catalytic residue [active] 266265010415 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 266265010416 LysE type translocator; Region: LysE; cl00565 266265010417 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266265010418 tetramer interface [polypeptide binding]; other site 266265010419 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 266265010420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265010421 catalytic residue [active] 266265010422 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266265010423 Uncharacterized conserved protein [Function unknown]; Region: COG5495 266265010424 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 266265010425 EthD domain; Region: EthD; cl17553 266265010426 YGGT family; Region: YGGT; pfam02325 266265010427 YGGT family; Region: YGGT; pfam02325 266265010428 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 266265010429 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 266265010430 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 266265010431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 266265010432 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 266265010433 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 266265010434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 266265010435 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 266265010436 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 266265010437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 266265010438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265010439 S-adenosylmethionine binding site [chemical binding]; other site 266265010440 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 266265010441 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 266265010442 Flagellin N-methylase; Region: FliB; pfam03692 266265010443 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 266265010444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265010445 FeS/SAM binding site; other site 266265010446 HemN C-terminal domain; Region: HemN_C; pfam06969 266265010447 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266265010448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265010449 Walker A motif; other site 266265010450 ATP binding site [chemical binding]; other site 266265010451 Walker B motif; other site 266265010452 arginine finger; other site 266265010453 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 266265010454 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265010455 ligand binding site [chemical binding]; other site 266265010456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265010457 ATP-binding site [chemical binding]; other site 266265010458 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 266265010459 putative homodimer interface [polypeptide binding]; other site 266265010460 putative active site [active] 266265010461 catalytic site [active] 266265010462 Part of AAA domain; Region: AAA_19; pfam13245 266265010463 Family description; Region: UvrD_C_2; pfam13538 266265010464 aromatic amino acid transporter; Provisional; Region: PRK10238 266265010465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265010466 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 266265010467 SxDxEG motif; other site 266265010468 active site 266265010469 metal binding site [ion binding]; metal-binding site 266265010470 homopentamer interface [polypeptide binding]; other site 266265010471 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 266265010472 homodimer interface [polypeptide binding]; other site 266265010473 homotetramer interface [polypeptide binding]; other site 266265010474 active site pocket [active] 266265010475 cleavage site 266265010476 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 266265010477 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266265010478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265010479 dimer interface [polypeptide binding]; other site 266265010480 conserved gate region; other site 266265010481 putative PBP binding loops; other site 266265010482 ABC-ATPase subunit interface; other site 266265010483 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 266265010484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265010485 dimer interface [polypeptide binding]; other site 266265010486 conserved gate region; other site 266265010487 putative PBP binding loops; other site 266265010488 ABC-ATPase subunit interface; other site 266265010489 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 266265010490 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 266265010491 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 266265010492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265010493 Walker A/P-loop; other site 266265010494 ATP binding site [chemical binding]; other site 266265010495 Q-loop/lid; other site 266265010496 ABC transporter signature motif; other site 266265010497 Walker B; other site 266265010498 D-loop; other site 266265010499 H-loop/switch region; other site 266265010500 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266265010501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265010502 Walker A/P-loop; other site 266265010503 ATP binding site [chemical binding]; other site 266265010504 Q-loop/lid; other site 266265010505 ABC transporter signature motif; other site 266265010506 Walker B; other site 266265010507 D-loop; other site 266265010508 H-loop/switch region; other site 266265010509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266265010510 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 266265010511 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 266265010512 catalytic nucleophile [active] 266265010513 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266265010514 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265010515 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266265010516 putative active site [active] 266265010517 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 266265010518 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 266265010519 RNA binding surface [nucleotide binding]; other site 266265010520 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 266265010521 active site 266265010522 uracil binding [chemical binding]; other site 266265010523 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265010524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265010525 NAD(P) binding site [chemical binding]; other site 266265010526 active site 266265010527 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266265010528 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265010529 catalytic loop [active] 266265010530 iron binding site [ion binding]; other site 266265010531 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 266265010532 FAD binding pocket [chemical binding]; other site 266265010533 FAD binding motif [chemical binding]; other site 266265010534 phosphate binding motif [ion binding]; other site 266265010535 beta-alpha-beta structure motif; other site 266265010536 NAD binding pocket [chemical binding]; other site 266265010537 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 266265010538 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265010539 inhibitor-cofactor binding pocket; inhibition site 266265010540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265010541 catalytic residue [active] 266265010542 putative acetyltransferase; Provisional; Region: PRK03624 266265010543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265010544 Coenzyme A binding pocket [chemical binding]; other site 266265010545 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265010546 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265010547 Walker A/P-loop; other site 266265010548 ATP binding site [chemical binding]; other site 266265010549 Q-loop/lid; other site 266265010550 ABC transporter signature motif; other site 266265010551 Walker B; other site 266265010552 D-loop; other site 266265010553 H-loop/switch region; other site 266265010554 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265010555 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265010556 Walker A/P-loop; other site 266265010557 ATP binding site [chemical binding]; other site 266265010558 Q-loop/lid; other site 266265010559 ABC transporter signature motif; other site 266265010560 Walker B; other site 266265010561 D-loop; other site 266265010562 H-loop/switch region; other site 266265010563 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265010564 TM-ABC transporter signature motif; other site 266265010565 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265010566 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265010567 TM-ABC transporter signature motif; other site 266265010568 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265010569 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266265010570 dimerization interface [polypeptide binding]; other site 266265010571 ligand binding site [chemical binding]; other site 266265010572 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 266265010573 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 266265010574 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 266265010575 hypothetical protein; Reviewed; Region: PRK00024 266265010576 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 266265010577 MPN+ (JAMM) motif; other site 266265010578 Zinc-binding site [ion binding]; other site 266265010579 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 266265010580 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 266265010581 L-aspartate oxidase; Provisional; Region: PRK09077 266265010582 L-aspartate oxidase; Provisional; Region: PRK06175 266265010583 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266265010584 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 266265010585 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 266265010586 dimerization interface [polypeptide binding]; other site 266265010587 active site 266265010588 quinolinate synthetase; Provisional; Region: PRK09375 266265010589 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 266265010590 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266265010591 Di-iron ligands [ion binding]; other site 266265010592 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266265010593 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266265010594 16S rRNA methyltransferase B; Provisional; Region: PRK14901 266265010595 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 266265010596 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 266265010597 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 266265010598 active site 266265010599 cosubstrate binding site; other site 266265010600 substrate binding site [chemical binding]; other site 266265010601 catalytic site [active] 266265010602 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 266265010603 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 266265010604 active site 266265010605 Riboflavin kinase; Region: Flavokinase; smart00904 266265010606 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 266265010607 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266265010608 active site 266265010609 HIGH motif; other site 266265010610 nucleotide binding site [chemical binding]; other site 266265010611 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266265010612 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 266265010613 active site 266265010614 KMSKS motif; other site 266265010615 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 266265010616 tRNA binding surface [nucleotide binding]; other site 266265010617 anticodon binding site; other site 266265010618 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 266265010619 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 266265010620 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 266265010621 Flavoprotein; Region: Flavoprotein; pfam02441 266265010622 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 266265010623 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 266265010624 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266265010625 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266265010626 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 266265010627 trimer interface [polypeptide binding]; other site 266265010628 active site 266265010629 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 266265010630 Clp amino terminal domain; Region: Clp_N; pfam02861 266265010631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265010632 Walker A motif; other site 266265010633 ATP binding site [chemical binding]; other site 266265010634 Walker B motif; other site 266265010635 arginine finger; other site 266265010636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265010637 Walker A motif; other site 266265010638 ATP binding site [chemical binding]; other site 266265010639 Walker B motif; other site 266265010640 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 266265010641 Uncharacterized conserved protein [Function unknown]; Region: COG2127 266265010642 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266265010643 DNA-binding site [nucleotide binding]; DNA binding site 266265010644 RNA-binding motif; other site 266265010645 isocitrate dehydrogenase; Validated; Region: PRK07362 266265010646 isocitrate dehydrogenase; Reviewed; Region: PRK07006 266265010647 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 266265010648 pseudouridine synthase; Region: TIGR00093 266265010649 active site 266265010650 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 266265010651 elongation factor G; Reviewed; Region: PRK00007 266265010652 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266265010653 G1 box; other site 266265010654 putative GEF interaction site [polypeptide binding]; other site 266265010655 GTP/Mg2+ binding site [chemical binding]; other site 266265010656 Switch I region; other site 266265010657 G2 box; other site 266265010658 G3 box; other site 266265010659 Switch II region; other site 266265010660 G4 box; other site 266265010661 G5 box; other site 266265010662 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266265010663 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266265010664 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266265010665 Cupin domain; Region: Cupin_2; cl17218 266265010666 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 266265010667 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265010668 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266265010669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266265010670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265010671 dimer interface [polypeptide binding]; other site 266265010672 conserved gate region; other site 266265010673 putative PBP binding loops; other site 266265010674 ABC-ATPase subunit interface; other site 266265010675 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266265010676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265010677 putative PBP binding loops; other site 266265010678 dimer interface [polypeptide binding]; other site 266265010679 ABC-ATPase subunit interface; other site 266265010680 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266265010681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265010682 Walker A/P-loop; other site 266265010683 ATP binding site [chemical binding]; other site 266265010684 Q-loop/lid; other site 266265010685 ABC transporter signature motif; other site 266265010686 Walker B; other site 266265010687 D-loop; other site 266265010688 H-loop/switch region; other site 266265010689 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265010690 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266265010691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265010692 Walker A/P-loop; other site 266265010693 ATP binding site [chemical binding]; other site 266265010694 Q-loop/lid; other site 266265010695 ABC transporter signature motif; other site 266265010696 Walker B; other site 266265010697 D-loop; other site 266265010698 H-loop/switch region; other site 266265010699 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265010700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265010701 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265010702 active site 266265010703 catalytic tetrad [active] 266265010704 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266265010705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265010706 DNA-binding site [nucleotide binding]; DNA binding site 266265010707 UTRA domain; Region: UTRA; pfam07702 266265010708 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265010709 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265010710 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 266265010711 DNA binding residues [nucleotide binding] 266265010712 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 266265010713 active site 266265010714 coenzyme A binding site [chemical binding]; other site 266265010715 citrylCoA binding site [chemical binding]; other site 266265010716 dimer interface [polypeptide binding]; other site 266265010717 Citrate synthase; Region: Citrate_synt; pfam00285 266265010718 oxalacetate/citrate binding site [chemical binding]; other site 266265010719 catalytic triad [active] 266265010720 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265010721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265010722 DNA-binding site [nucleotide binding]; DNA binding site 266265010723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265010724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265010725 homodimer interface [polypeptide binding]; other site 266265010726 catalytic residue [active] 266265010727 putative transporter; Provisional; Region: PRK10504 266265010728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265010729 putative substrate translocation pore; other site 266265010730 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265010731 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265010732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265010733 DNA binding residues [nucleotide binding] 266265010734 Clp protease; Region: CLP_protease; pfam00574 266265010735 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 266265010736 oligomer interface [polypeptide binding]; other site 266265010737 active site residues [active] 266265010738 LabA_like proteins; Region: LabA_like; cd06167 266265010739 putative metal binding site [ion binding]; other site 266265010740 Uncharacterized conserved protein [Function unknown]; Region: COG1432 266265010741 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 266265010742 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266265010743 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 266265010744 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 266265010745 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 266265010746 dimer interface [polypeptide binding]; other site 266265010747 active site 266265010748 heme binding site [chemical binding]; other site 266265010749 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 266265010750 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 266265010751 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 266265010752 superoxide dismutase; Provisional; Region: PRK10543 266265010753 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 266265010754 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266265010755 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 266265010756 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 266265010757 generic binding surface II; other site 266265010758 generic binding surface I; other site 266265010759 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 266265010760 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 266265010761 Uncharacterized conserved protein [Function unknown]; Region: COG2835 266265010762 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 266265010763 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 266265010764 Ligand binding site; other site 266265010765 oligomer interface; other site 266265010766 adenylate kinase; Reviewed; Region: adk; PRK00279 266265010767 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 266265010768 AMP-binding site [chemical binding]; other site 266265010769 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 266265010770 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 266265010771 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 266265010772 NAD binding site [chemical binding]; other site 266265010773 homodimer interface [polypeptide binding]; other site 266265010774 homotetramer interface [polypeptide binding]; other site 266265010775 active site 266265010776 Uncharacterized conserved protein [Function unknown]; Region: COG2912 266265010777 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 266265010778 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 266265010779 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 266265010780 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 266265010781 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 266265010782 ornithine carbamoyltransferase; Provisional; Region: PRK00779 266265010783 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266265010784 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266265010785 argininosuccinate synthase; Provisional; Region: PRK13820 266265010786 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 266265010787 ANP binding site [chemical binding]; other site 266265010788 Substrate Binding Site II [chemical binding]; other site 266265010789 Substrate Binding Site I [chemical binding]; other site 266265010790 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 266265010791 FAD binding domain; Region: FAD_binding_4; pfam01565 266265010792 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 266265010793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 266265010794 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 266265010795 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 266265010796 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 266265010797 putative deacylase active site [active] 266265010798 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265010799 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265010800 acyl-activating enzyme (AAE) consensus motif; other site 266265010801 AMP binding site [chemical binding]; other site 266265010802 active site 266265010803 CoA binding site [chemical binding]; other site 266265010804 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 266265010805 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 266265010806 active site 266265010807 Int/Topo IB signature motif; other site 266265010808 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 266265010809 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266265010810 DNA binding site [nucleotide binding] 266265010811 active site 266265010812 epoxyqueuosine reductase; Region: TIGR00276 266265010813 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 266265010814 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 266265010815 AMIN domain; Region: AMIN; pfam11741 266265010816 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 266265010817 active site 266265010818 metal binding site [ion binding]; metal-binding site 266265010819 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 266265010820 EamA-like transporter family; Region: EamA; pfam00892 266265010821 Pirin-related protein [General function prediction only]; Region: COG1741 266265010822 Pirin; Region: Pirin; pfam02678 266265010823 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 266265010824 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 266265010825 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266265010826 catalytic residues [active] 266265010827 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 266265010828 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 266265010829 putative ATP binding site [chemical binding]; other site 266265010830 putative substrate interface [chemical binding]; other site 266265010831 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 266265010832 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 266265010833 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 266265010834 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266265010835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265010836 S-adenosylmethionine binding site [chemical binding]; other site 266265010837 Protein of unknown function DUF72; Region: DUF72; pfam01904 266265010838 methionine sulfoxide reductase A; Provisional; Region: PRK14054 266265010839 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 266265010840 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265010841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265010842 putative DNA binding site [nucleotide binding]; other site 266265010843 putative Zn2+ binding site [ion binding]; other site 266265010844 AsnC family; Region: AsnC_trans_reg; pfam01037 266265010845 arylformamidase; Region: trp_arylform; TIGR03035 266265010846 kynureninase; Region: kynureninase; TIGR01814 266265010847 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 266265010848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265010849 catalytic residue [active] 266265010850 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 266265010851 Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375 266265010852 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265010853 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265010854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265010855 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 266265010856 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 266265010857 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 266265010858 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 266265010859 N- and C-terminal domain interface [polypeptide binding]; other site 266265010860 D-xylulose kinase; Region: XylB; TIGR01312 266265010861 active site 266265010862 MgATP binding site [chemical binding]; other site 266265010863 catalytic site [active] 266265010864 metal binding site [ion binding]; metal-binding site 266265010865 xylulose binding site [chemical binding]; other site 266265010866 homodimer interface [polypeptide binding]; other site 266265010867 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 266265010868 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 266265010869 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 266265010870 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265010871 FAD binding domain; Region: FAD_binding_4; pfam01565 266265010872 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 266265010873 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 266265010874 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266265010875 Walker A/P-loop; other site 266265010876 ATP binding site [chemical binding]; other site 266265010877 Q-loop/lid; other site 266265010878 ABC transporter signature motif; other site 266265010879 Walker B; other site 266265010880 D-loop; other site 266265010881 H-loop/switch region; other site 266265010882 TOBE domain; Region: TOBE_2; pfam08402 266265010883 TOBE domain; Region: TOBE_2; pfam08402 266265010884 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266265010885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265010886 active site 266265010887 motif I; other site 266265010888 motif II; other site 266265010889 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266265010890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265010891 dimer interface [polypeptide binding]; other site 266265010892 conserved gate region; other site 266265010893 putative PBP binding loops; other site 266265010894 ABC-ATPase subunit interface; other site 266265010895 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266265010896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265010897 dimer interface [polypeptide binding]; other site 266265010898 conserved gate region; other site 266265010899 putative PBP binding loops; other site 266265010900 ABC-ATPase subunit interface; other site 266265010901 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266265010902 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266265010903 sorbitol dehydrogenase; Provisional; Region: PRK07067 266265010904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265010905 NAD(P) binding site [chemical binding]; other site 266265010906 active site 266265010907 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266265010908 metal binding site 2 [ion binding]; metal-binding site 266265010909 putative DNA binding helix; other site 266265010910 metal binding site 1 [ion binding]; metal-binding site 266265010911 dimer interface [polypeptide binding]; other site 266265010912 structural Zn2+ binding site [ion binding]; other site 266265010913 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 266265010914 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 266265010915 metal binding site [ion binding]; metal-binding site 266265010916 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 266265010917 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 266265010918 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 266265010919 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 266265010920 ABC-ATPase subunit interface; other site 266265010921 dimer interface [polypeptide binding]; other site 266265010922 putative PBP binding regions; other site 266265010923 S-formylglutathione hydrolase; Region: PLN02442 266265010924 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 266265010925 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 266265010926 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 266265010927 substrate binding site [chemical binding]; other site 266265010928 catalytic Zn binding site [ion binding]; other site 266265010929 NAD binding site [chemical binding]; other site 266265010930 structural Zn binding site [ion binding]; other site 266265010931 dimer interface [polypeptide binding]; other site 266265010932 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 266265010933 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266265010934 nucleotide binding site [chemical binding]; other site 266265010935 xanthine permease; Region: pbuX; TIGR03173 266265010936 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 266265010937 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 266265010938 Protein export membrane protein; Region: SecD_SecF; cl14618 266265010939 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266265010940 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 266265010941 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265010942 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265010943 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 266265010944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265010945 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 266265010946 Isochorismatase family; Region: Isochorismatase; pfam00857 266265010947 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 266265010948 catalytic triad [active] 266265010949 conserved cis-peptide bond; other site 266265010950 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 266265010951 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266265010952 conserved cys residue [active] 266265010953 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266265010954 hydrophobic ligand binding site; other site 266265010955 Domain of unknown function (DUF427); Region: DUF427; pfam04248 266265010956 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 266265010957 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 266265010958 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266265010959 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266265010960 protein binding site [polypeptide binding]; other site 266265010961 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266265010962 protein binding site [polypeptide binding]; other site 266265010963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266265010964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265010965 dimer interface [polypeptide binding]; other site 266265010966 phosphorylation site [posttranslational modification] 266265010967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265010968 ATP binding site [chemical binding]; other site 266265010969 Mg2+ binding site [ion binding]; other site 266265010970 G-X-G motif; other site 266265010971 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 266265010972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265010973 active site 266265010974 phosphorylation site [posttranslational modification] 266265010975 intermolecular recognition site; other site 266265010976 dimerization interface [polypeptide binding]; other site 266265010977 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265010978 DNA binding site [nucleotide binding] 266265010979 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 266265010980 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266265010981 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266265010982 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 266265010983 active site 266265010984 catalytic triad [active] 266265010985 oxyanion hole [active] 266265010986 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 266265010987 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 266265010988 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 266265010989 ATP-grasp domain; Region: ATP-grasp; pfam02222 266265010990 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 266265010991 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 266265010992 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 266265010993 ATP binding site [chemical binding]; other site 266265010994 active site 266265010995 substrate binding site [chemical binding]; other site 266265010996 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 266265010997 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266265010998 intersubunit interface [polypeptide binding]; other site 266265010999 active site 266265011000 zinc binding site [ion binding]; other site 266265011001 Na+ binding site [ion binding]; other site 266265011002 pyruvate kinase; Provisional; Region: PRK05826 266265011003 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 266265011004 domain interfaces; other site 266265011005 active site 266265011006 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 266265011007 Phosphoglycerate kinase; Region: PGK; pfam00162 266265011008 substrate binding site [chemical binding]; other site 266265011009 hinge regions; other site 266265011010 ADP binding site [chemical binding]; other site 266265011011 catalytic site [active] 266265011012 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 266265011013 AzlC protein; Region: AzlC; pfam03591 266265011014 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266265011015 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266265011016 homodimer interface [polypeptide binding]; other site 266265011017 substrate-cofactor binding pocket; other site 266265011018 catalytic residue [active] 266265011019 Zinc-finger domain; Region: zf-CHCC; cl01821 266265011020 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266265011021 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266265011022 putative active site [active] 266265011023 SnoaL-like domain; Region: SnoaL_3; pfam13474 266265011024 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 266265011025 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 266265011026 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 266265011027 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 266265011028 Peptidase family M48; Region: Peptidase_M48; pfam01435 266265011029 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 266265011030 trimer interface [polypeptide binding]; other site 266265011031 dimer interface [polypeptide binding]; other site 266265011032 putative active site [active] 266265011033 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 266265011034 O-Antigen ligase; Region: Wzy_C; pfam04932 266265011035 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 266265011036 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 266265011037 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 266265011038 Pilin (bacterial filament); Region: Pilin; pfam00114 266265011039 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 266265011040 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 266265011041 CoA binding domain; Region: CoA_binding; smart00881 266265011042 CoA-ligase; Region: Ligase_CoA; pfam00549 266265011043 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 266265011044 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 266265011045 CoA-ligase; Region: Ligase_CoA; pfam00549 266265011046 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266265011047 RecX family; Region: RecX; cl00936 266265011048 recombinase A; Provisional; Region: recA; PRK09354 266265011049 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 266265011050 hexamer interface [polypeptide binding]; other site 266265011051 Walker A motif; other site 266265011052 ATP binding site [chemical binding]; other site 266265011053 Walker B motif; other site 266265011054 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265011055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265011056 active site 266265011057 phosphorylation site [posttranslational modification] 266265011058 intermolecular recognition site; other site 266265011059 dimerization interface [polypeptide binding]; other site 266265011060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265011061 DNA binding site [nucleotide binding] 266265011062 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266265011063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265011064 HAMP domain; Region: HAMP; pfam00672 266265011065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265011066 dimer interface [polypeptide binding]; other site 266265011067 phosphorylation site [posttranslational modification] 266265011068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265011069 ATP binding site [chemical binding]; other site 266265011070 Mg2+ binding site [ion binding]; other site 266265011071 G-X-G motif; other site 266265011072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265011073 putative substrate translocation pore; other site 266265011074 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 266265011075 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 266265011076 Phosphoesterase family; Region: Phosphoesterase; pfam04185 266265011077 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266265011078 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266265011079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265011080 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 266265011081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265011082 dimerization interface [polypeptide binding]; other site 266265011083 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265011084 MarR family; Region: MarR; pfam01047 266265011085 MarR family; Region: MarR_2; cl17246 266265011086 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265011087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265011088 putative substrate translocation pore; other site 266265011089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265011090 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265011091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265011092 DNA-binding site [nucleotide binding]; DNA binding site 266265011093 FCD domain; Region: FCD; pfam07729 266265011094 galactonate dehydratase; Provisional; Region: PRK14017 266265011095 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 266265011096 putative active site pocket [active] 266265011097 putative metal binding site [ion binding]; other site 266265011098 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 266265011099 CopC domain; Region: CopC; pfam04234 266265011100 Cytochrome c553 [Energy production and conversion]; Region: COG2863 266265011101 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265011102 Cytochrome c; Region: Cytochrom_C; cl11414 266265011103 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265011104 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265011105 Cytochrome c; Region: Cytochrom_C; pfam00034 266265011106 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265011107 Cytochrome c; Region: Cytochrom_C; pfam00034 266265011108 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 266265011109 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 266265011110 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 266265011111 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 266265011112 ATP binding site [chemical binding]; other site 266265011113 Mg++ binding site [ion binding]; other site 266265011114 motif III; other site 266265011115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265011116 nucleotide binding region [chemical binding]; other site 266265011117 ATP-binding site [chemical binding]; other site 266265011118 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 266265011119 dinuclear metal binding motif [ion binding]; other site 266265011120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265011121 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265011122 putative substrate translocation pore; other site 266265011123 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266265011124 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266265011125 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266265011126 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 266265011127 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266265011128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265011129 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266265011130 DNA-binding interface [nucleotide binding]; DNA binding site 266265011131 WHG domain; Region: WHG; pfam13305 266265011132 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 266265011133 glycerol kinase; Provisional; Region: glpK; PRK00047 266265011134 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 266265011135 N- and C-terminal domain interface [polypeptide binding]; other site 266265011136 active site 266265011137 MgATP binding site [chemical binding]; other site 266265011138 catalytic site [active] 266265011139 metal binding site [ion binding]; metal-binding site 266265011140 glycerol binding site [chemical binding]; other site 266265011141 homotetramer interface [polypeptide binding]; other site 266265011142 homodimer interface [polypeptide binding]; other site 266265011143 FBP binding site [chemical binding]; other site 266265011144 protein IIAGlc interface [polypeptide binding]; other site 266265011145 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 266265011146 amphipathic channel; other site 266265011147 Asn-Pro-Ala signature motifs; other site 266265011148 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266265011149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265011150 active site 266265011151 motif I; other site 266265011152 motif II; other site 266265011153 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 266265011154 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 266265011155 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265011156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265011157 non-specific DNA binding site [nucleotide binding]; other site 266265011158 salt bridge; other site 266265011159 sequence-specific DNA binding site [nucleotide binding]; other site 266265011160 Cupin domain; Region: Cupin_2; pfam07883 266265011161 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266265011162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265011163 putative substrate translocation pore; other site 266265011164 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 266265011165 dimer interface [polypeptide binding]; other site 266265011166 putative metal binding site [ion binding]; other site 266265011167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265011168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265011169 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265011170 putative effector binding pocket; other site 266265011171 dimerization interface [polypeptide binding]; other site 266265011172 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 266265011173 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 266265011174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265011175 FeS/SAM binding site; other site 266265011176 TRAM domain; Region: TRAM; pfam01938 266265011177 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 266265011178 PhoH-like protein; Region: PhoH; pfam02562 266265011179 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 266265011180 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 266265011181 putative active site pocket [active] 266265011182 dimerization interface [polypeptide binding]; other site 266265011183 putative catalytic residue [active] 266265011184 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 266265011185 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266265011186 Transporter associated domain; Region: CorC_HlyC; smart01091 266265011187 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 266265011188 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 266265011189 putative active site [active] 266265011190 catalytic triad [active] 266265011191 putative dimer interface [polypeptide binding]; other site 266265011192 putative glutathione S-transferase; Provisional; Region: PRK10357 266265011193 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 266265011194 putative C-terminal domain interface [polypeptide binding]; other site 266265011195 putative GSH binding site (G-site) [chemical binding]; other site 266265011196 putative dimer interface [polypeptide binding]; other site 266265011197 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 266265011198 dimer interface [polypeptide binding]; other site 266265011199 N-terminal domain interface [polypeptide binding]; other site 266265011200 putative substrate binding pocket (H-site) [chemical binding]; other site 266265011201 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 266265011202 proline aminopeptidase P II; Provisional; Region: PRK10879 266265011203 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 266265011204 active site 266265011205 hypothetical protein; Provisional; Region: PRK06996 266265011206 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265011207 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265011208 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 266265011209 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 266265011210 FMN binding site [chemical binding]; other site 266265011211 active site 266265011212 catalytic residues [active] 266265011213 substrate binding site [chemical binding]; other site 266265011214 DNA-binding protein Fis; Provisional; Region: PRK01905 266265011215 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 266265011216 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 266265011217 purine monophosphate binding site [chemical binding]; other site 266265011218 dimer interface [polypeptide binding]; other site 266265011219 putative catalytic residues [active] 266265011220 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 266265011221 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 266265011222 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 266265011223 active site 266265011224 putative DNA-binding cleft [nucleotide binding]; other site 266265011225 dimer interface [polypeptide binding]; other site 266265011226 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 266265011227 RuvA N terminal domain; Region: RuvA_N; pfam01330 266265011228 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 266265011229 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 266265011230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265011231 Walker A motif; other site 266265011232 ATP binding site [chemical binding]; other site 266265011233 Walker B motif; other site 266265011234 arginine finger; other site 266265011235 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 266265011236 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 266265011237 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266265011238 catalytic core [active] 266265011239 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 266265011240 putative active site [active] 266265011241 dimerization interface [polypeptide binding]; other site 266265011242 putative tRNAtyr binding site [nucleotide binding]; other site 266265011243 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 266265011244 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 266265011245 active site 266265011246 HIGH motif; other site 266265011247 dimer interface [polypeptide binding]; other site 266265011248 KMSKS motif; other site 266265011249 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266265011250 RNA binding surface [nucleotide binding]; other site 266265011251 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 266265011252 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 266265011253 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 266265011254 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 266265011255 23S rRNA interface [nucleotide binding]; other site 266265011256 L3 interface [polypeptide binding]; other site 266265011257 OsmC-like protein; Region: OsmC; cl00767 266265011258 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 266265011259 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 266265011260 active site 266265011261 substrate binding pocket [chemical binding]; other site 266265011262 dimer interface [polypeptide binding]; other site 266265011263 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 266265011264 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 266265011265 putative active site [active] 266265011266 putative dimer interface [polypeptide binding]; other site 266265011267 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265011268 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265011269 Walker A/P-loop; other site 266265011270 ATP binding site [chemical binding]; other site 266265011271 Q-loop/lid; other site 266265011272 ABC transporter signature motif; other site 266265011273 Walker B; other site 266265011274 D-loop; other site 266265011275 H-loop/switch region; other site 266265011276 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265011277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265011278 dimer interface [polypeptide binding]; other site 266265011279 conserved gate region; other site 266265011280 putative PBP binding loops; other site 266265011281 ABC-ATPase subunit interface; other site 266265011282 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265011283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265011284 dimer interface [polypeptide binding]; other site 266265011285 conserved gate region; other site 266265011286 putative PBP binding loops; other site 266265011287 ABC-ATPase subunit interface; other site 266265011288 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 266265011289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265011290 substrate binding pocket [chemical binding]; other site 266265011291 membrane-bound complex binding site; other site 266265011292 hinge residues; other site 266265011293 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 266265011294 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 266265011295 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 266265011296 NAD(P) binding site [chemical binding]; other site 266265011297 cell density-dependent motility repressor; Provisional; Region: PRK10082 266265011298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265011299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265011300 dimerization interface [polypeptide binding]; other site 266265011301 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266265011302 active site 266265011303 adenylosuccinate lyase; Provisional; Region: PRK09285 266265011304 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 266265011305 tetramer interface [polypeptide binding]; other site 266265011306 active site 266265011307 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 266265011308 ATP-binding site [chemical binding]; other site 266265011309 Gluconate-6-phosphate binding site [chemical binding]; other site 266265011310 Shikimate kinase; Region: SKI; pfam01202 266265011311 GntP family permease; Region: GntP_permease; pfam02447 266265011312 fructuronate transporter; Provisional; Region: PRK10034; cl15264 266265011313 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 266265011314 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266265011315 active site 266265011316 intersubunit interface [polypeptide binding]; other site 266265011317 catalytic residue [active] 266265011318 phosphogluconate dehydratase; Validated; Region: PRK09054 266265011319 6-phosphogluconate dehydratase; Region: edd; TIGR01196 266265011320 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266265011321 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265011322 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266265011323 putative active site [active] 266265011324 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266265011325 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265011326 ligand binding site [chemical binding]; other site 266265011327 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 266265011328 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266265011329 trimer interface [polypeptide binding]; other site 266265011330 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266265011331 trimer interface [polypeptide binding]; other site 266265011332 YadA-like C-terminal region; Region: YadA; pfam03895 266265011333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 266265011334 SnoaL-like domain; Region: SnoaL_2; pfam12680 266265011335 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 266265011336 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 266265011337 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 266265011338 putative catalytic cysteine [active] 266265011339 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 266265011340 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 266265011341 Lipopolysaccharide-assembly; Region: LptE; cl01125 266265011342 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 266265011343 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 266265011344 HIGH motif; other site 266265011345 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 266265011346 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 266265011347 active site 266265011348 KMSKS motif; other site 266265011349 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 266265011350 tRNA binding surface [nucleotide binding]; other site 266265011351 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 266265011352 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265011353 TolR protein; Region: tolR; TIGR02801 266265011354 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 266265011355 dihydrodipicolinate reductase; Provisional; Region: PRK00048 266265011356 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 266265011357 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 266265011358 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 266265011359 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 266265011360 ferric uptake regulator; Provisional; Region: fur; PRK09462 266265011361 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266265011362 metal binding site 2 [ion binding]; metal-binding site 266265011363 putative DNA binding helix; other site 266265011364 metal binding site 1 [ion binding]; metal-binding site 266265011365 dimer interface [polypeptide binding]; other site 266265011366 structural Zn2+ binding site [ion binding]; other site 266265011367 ureidoglycolate hydrolase; Provisional; Region: PRK13395 266265011368 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 266265011369 allantoicase; Provisional; Region: PRK13257 266265011370 Allantoicase repeat; Region: Allantoicase; pfam03561 266265011371 Allantoicase repeat; Region: Allantoicase; pfam03561 266265011372 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 266265011373 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 266265011374 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265011375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265011376 DNA-binding site [nucleotide binding]; DNA binding site 266265011377 FCD domain; Region: FCD; pfam07729 266265011378 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 266265011379 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 266265011380 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 266265011381 transketolase; Reviewed; Region: PRK12753 266265011382 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266265011383 TPP-binding site [chemical binding]; other site 266265011384 dimer interface [polypeptide binding]; other site 266265011385 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266265011386 PYR/PP interface [polypeptide binding]; other site 266265011387 dimer interface [polypeptide binding]; other site 266265011388 TPP binding site [chemical binding]; other site 266265011389 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266265011390 spermidine synthase; Provisional; Region: PRK00811 266265011391 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 266265011392 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265011393 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266265011394 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266265011395 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 266265011396 putative dimer interface [polypeptide binding]; other site 266265011397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265011398 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 266265011399 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 266265011400 putative RNAase interaction site [polypeptide binding]; other site 266265011401 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 266265011402 active site 266265011403 barstar interaction site; other site 266265011404 malic enzyme; Reviewed; Region: PRK12862 266265011405 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266265011406 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266265011407 putative NAD(P) binding site [chemical binding]; other site 266265011408 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266265011409 thiamine monophosphate kinase; Provisional; Region: PRK05731 266265011410 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 266265011411 ATP binding site [chemical binding]; other site 266265011412 dimerization interface [polypeptide binding]; other site 266265011413 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 266265011414 tetramer interfaces [polypeptide binding]; other site 266265011415 binuclear metal-binding site [ion binding]; other site 266265011416 Competence-damaged protein; Region: CinA; pfam02464 266265011417 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 266265011418 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 266265011419 active site 266265011420 dimer interface [polypeptide binding]; other site 266265011421 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 266265011422 active site 266265011423 catalytic residues [active] 266265011424 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265011425 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265011426 classical (c) SDRs; Region: SDR_c; cd05233 266265011427 NAD(P) binding site [chemical binding]; other site 266265011428 active site 266265011429 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265011430 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265011431 TM-ABC transporter signature motif; other site 266265011432 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 266265011433 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265011434 Walker A/P-loop; other site 266265011435 ATP binding site [chemical binding]; other site 266265011436 Q-loop/lid; other site 266265011437 ABC transporter signature motif; other site 266265011438 Walker B; other site 266265011439 D-loop; other site 266265011440 H-loop/switch region; other site 266265011441 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265011442 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266265011443 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 266265011444 ligand binding site [chemical binding]; other site 266265011445 short chain dehydrogenase; Provisional; Region: PRK07063 266265011446 classical (c) SDRs; Region: SDR_c; cd05233 266265011447 NAD(P) binding site [chemical binding]; other site 266265011448 active site 266265011449 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 266265011450 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 266265011451 active site 266265011452 intersubunit interface [polypeptide binding]; other site 266265011453 catalytic residue [active] 266265011454 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 266265011455 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 266265011456 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265011457 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265011458 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265011459 Winged helix-turn helix; Region: HTH_29; pfam13551 266265011460 Helix-turn-helix domain; Region: HTH_28; pfam13518 266265011461 Homeodomain-like domain; Region: HTH_32; pfam13565 266265011462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266265011463 Integrase core domain; Region: rve; pfam00665 266265011464 Integrase core domain; Region: rve_3; pfam13683 266265011465 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 266265011466 Transglycosylase; Region: Transgly; cl17702 266265011467 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 266265011468 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266265011469 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266265011470 shikimate binding site; other site 266265011471 NAD(P) binding site [chemical binding]; other site 266265011472 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 266265011473 RNB domain; Region: RNB; pfam00773 266265011474 Uncharacterized protein family (UPF0227); Region: UPF0227; pfam05728 266265011475 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265011476 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 266265011477 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266265011478 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266265011479 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266265011480 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 266265011481 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266265011482 catalytic residues [active] 266265011483 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 266265011484 Dehydroquinase class II; Region: DHquinase_II; pfam01220 266265011485 active site 266265011486 trimer interface [polypeptide binding]; other site 266265011487 dimer interface [polypeptide binding]; other site 266265011488 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 266265011489 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266265011490 carboxyltransferase (CT) interaction site; other site 266265011491 biotinylation site [posttranslational modification]; other site 266265011492 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266265011493 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266265011494 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 266265011495 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266265011496 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 266265011497 DNA methylase; Region: N6_N4_Mtase; cl17433 266265011498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265011499 S-adenosylmethionine binding site [chemical binding]; other site 266265011500 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 266265011501 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 266265011502 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 266265011503 dimer interface [polypeptide binding]; other site 266265011504 catalytic triad [active] 266265011505 peroxidatic and resolving cysteines [active] 266265011506 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 266265011507 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265011508 substrate binding site [chemical binding]; other site 266265011509 ATP binding site [chemical binding]; other site 266265011510 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 266265011511 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 266265011512 dimer interface [polypeptide binding]; other site 266265011513 putative radical transfer pathway; other site 266265011514 diiron center [ion binding]; other site 266265011515 tyrosyl radical; other site 266265011516 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 266265011517 ATP cone domain; Region: ATP-cone; pfam03477 266265011518 Class I ribonucleotide reductase; Region: RNR_I; cd01679 266265011519 active site 266265011520 dimer interface [polypeptide binding]; other site 266265011521 catalytic residues [active] 266265011522 effector binding site; other site 266265011523 R2 peptide binding site; other site 266265011524 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 266265011525 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266265011526 amidase catalytic site [active] 266265011527 Zn binding residues [ion binding]; other site 266265011528 substrate binding site [chemical binding]; other site 266265011529 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266265011530 signal recognition particle protein; Provisional; Region: PRK10867 266265011531 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 266265011532 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 266265011533 P loop; other site 266265011534 GTP binding site [chemical binding]; other site 266265011535 Signal peptide binding domain; Region: SRP_SPB; pfam02978 266265011536 Methyl-coenzyme M reductase operon protein C; Region: MCR_C; cl01674 266265011537 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265011538 active site 266265011539 MarC family integral membrane protein; Region: MarC; cl00919 266265011540 prolyl-tRNA synthetase; Provisional; Region: PRK09194 266265011541 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 266265011542 dimer interface [polypeptide binding]; other site 266265011543 motif 1; other site 266265011544 active site 266265011545 motif 2; other site 266265011546 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 266265011547 putative deacylase active site [active] 266265011548 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 266265011549 active site 266265011550 motif 3; other site 266265011551 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 266265011552 anticodon binding site; other site 266265011553 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 266265011554 putative active site [active] 266265011555 Ap4A binding site [chemical binding]; other site 266265011556 nudix motif; other site 266265011557 putative metal binding site [ion binding]; other site 266265011558 CNP1-like family; Region: CNP1; pfam08750 266265011559 gamma-glutamyl kinase; Provisional; Region: PRK05429 266265011560 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 266265011561 nucleotide binding site [chemical binding]; other site 266265011562 homotetrameric interface [polypeptide binding]; other site 266265011563 putative phosphate binding site [ion binding]; other site 266265011564 putative allosteric binding site; other site 266265011565 PUA domain; Region: PUA; pfam01472 266265011566 GTPase CgtA; Reviewed; Region: obgE; PRK12299 266265011567 GTP1/OBG; Region: GTP1_OBG; pfam01018 266265011568 Obg GTPase; Region: Obg; cd01898 266265011569 G1 box; other site 266265011570 GTP/Mg2+ binding site [chemical binding]; other site 266265011571 Switch I region; other site 266265011572 G2 box; other site 266265011573 G3 box; other site 266265011574 Switch II region; other site 266265011575 G4 box; other site 266265011576 G5 box; other site 266265011577 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 266265011578 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 266265011579 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 266265011580 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266265011581 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266265011582 substrate binding pocket [chemical binding]; other site 266265011583 chain length determination region; other site 266265011584 substrate-Mg2+ binding site; other site 266265011585 catalytic residues [active] 266265011586 aspartate-rich region 1; other site 266265011587 active site lid residues [active] 266265011588 aspartate-rich region 2; other site 266265011589 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 266265011590 Domain of unknown function DUF21; Region: DUF21; pfam01595 266265011591 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266265011592 Transporter associated domain; Region: CorC_HlyC; smart01091 266265011593 Type II/IV secretion system protein; Region: T2SE; pfam00437 266265011594 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265011595 Walker A motif; other site 266265011596 ATP binding site [chemical binding]; other site 266265011597 Walker B motif; other site 266265011598 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 266265011599 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266265011600 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 266265011601 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 266265011602 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 266265011603 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 266265011604 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 266265011605 CoA-binding site [chemical binding]; other site 266265011606 ATP-binding [chemical binding]; other site 266265011607 hypothetical protein; Provisional; Region: PRK05287 266265011608 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 266265011609 active site 266265011610 8-oxo-dGMP binding site [chemical binding]; other site 266265011611 nudix motif; other site 266265011612 metal binding site [ion binding]; metal-binding site 266265011613 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 266265011614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265011615 Walker A motif; other site 266265011616 ATP binding site [chemical binding]; other site 266265011617 Walker B motif; other site 266265011618 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 266265011619 heterotetramer interface [polypeptide binding]; other site 266265011620 active site pocket [active] 266265011621 cleavage site 266265011622 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 266265011623 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 266265011624 SEC-C motif; Region: SEC-C; pfam02810 266265011625 Protein of unknown function (DUF721); Region: DUF721; pfam05258 266265011626 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 266265011627 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 266265011628 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 266265011629 catalytic triad [active] 266265011630 dimer interface [polypeptide binding]; other site 266265011631 cell division protein FtsZ; Validated; Region: PRK09330 266265011632 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 266265011633 nucleotide binding site [chemical binding]; other site 266265011634 SulA interaction site; other site 266265011635 cell division protein FtsA; Region: ftsA; TIGR01174 266265011636 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266265011637 nucleotide binding site [chemical binding]; other site 266265011638 Cell division protein FtsA; Region: FtsA; pfam14450 266265011639 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 266265011640 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 266265011641 Cell division protein FtsQ; Region: FtsQ; pfam03799 266265011642 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 266265011643 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 266265011644 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 266265011645 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 266265011646 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266265011647 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266265011648 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266265011649 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 266265011650 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 266265011651 active site 266265011652 homodimer interface [polypeptide binding]; other site 266265011653 cell division protein FtsW; Region: ftsW; TIGR02614 266265011654 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 266265011655 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266265011656 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266265011657 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 266265011658 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 266265011659 Mg++ binding site [ion binding]; other site 266265011660 putative catalytic motif [active] 266265011661 putative substrate binding site [chemical binding]; other site 266265011662 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 266265011663 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266265011664 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266265011665 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266265011666 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 266265011667 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 266265011668 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266265011669 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266265011670 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266265011671 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266265011672 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266265011673 Cell division protein FtsL; Region: FtsL; cl11433 266265011674 MraW methylase family; Region: Methyltransf_5; cl17771 266265011675 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 266265011676 cell division protein MraZ; Reviewed; Region: PRK00326 266265011677 MraZ protein; Region: MraZ; pfam02381 266265011678 MraZ protein; Region: MraZ; pfam02381 266265011679 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 266265011680 diiron binding motif [ion binding]; other site 266265011681 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265011682 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265011683 trimer interface [polypeptide binding]; other site 266265011684 eyelet of channel; other site 266265011685 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 266265011686 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 266265011687 acyl-activating enzyme (AAE) consensus motif; other site 266265011688 putative AMP binding site [chemical binding]; other site 266265011689 putative active site [active] 266265011690 putative CoA binding site [chemical binding]; other site 266265011691 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 266265011692 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266265011693 putative [4Fe-4S] binding site [ion binding]; other site 266265011694 putative molybdopterin cofactor binding site [chemical binding]; other site 266265011695 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 266265011696 putative molybdopterin cofactor binding site; other site 266265011697 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266265011698 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266265011699 metal binding site [ion binding]; metal-binding site 266265011700 putative dimer interface [polypeptide binding]; other site 266265011701 enoyl-CoA hydratase; Provisional; Region: PRK05862 266265011702 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265011703 substrate binding site [chemical binding]; other site 266265011704 oxyanion hole (OAH) forming residues; other site 266265011705 trimer interface [polypeptide binding]; other site 266265011706 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 266265011707 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265011708 NAD(P) binding site [chemical binding]; other site 266265011709 catalytic residues [active] 266265011710 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 266265011711 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265011712 dimer interface [polypeptide binding]; other site 266265011713 active site 266265011714 enoyl-CoA hydratase; Provisional; Region: PRK08140 266265011715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265011716 substrate binding site [chemical binding]; other site 266265011717 oxyanion hole (OAH) forming residues; other site 266265011718 trimer interface [polypeptide binding]; other site 266265011719 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266265011720 CoenzymeA binding site [chemical binding]; other site 266265011721 subunit interaction site [polypeptide binding]; other site 266265011722 PHB binding site; other site 266265011723 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 266265011724 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 266265011725 active site 266265011726 AMP binding site [chemical binding]; other site 266265011727 homodimer interface [polypeptide binding]; other site 266265011728 acyl-activating enzyme (AAE) consensus motif; other site 266265011729 CoA binding site [chemical binding]; other site 266265011730 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 266265011731 MltA specific insert domain; Region: MltA; smart00925 266265011732 3D domain; Region: 3D; pfam06725 266265011733 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 266265011734 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266265011735 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 266265011736 substrate binding site [chemical binding]; other site 266265011737 hexamer interface [polypeptide binding]; other site 266265011738 metal binding site [ion binding]; metal-binding site 266265011739 phosphoglycolate phosphatase; Provisional; Region: PRK13222 266265011740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265011741 motif II; other site 266265011742 anthranilate synthase component I; Provisional; Region: PRK13565 266265011743 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 266265011744 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 266265011745 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 266265011746 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 266265011747 glutamine binding [chemical binding]; other site 266265011748 catalytic triad [active] 266265011749 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 266265011750 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 266265011751 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 266265011752 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 266265011753 active site 266265011754 ribulose/triose binding site [chemical binding]; other site 266265011755 phosphate binding site [ion binding]; other site 266265011756 substrate (anthranilate) binding pocket [chemical binding]; other site 266265011757 product (indole) binding pocket [chemical binding]; other site 266265011758 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 266265011759 putative active site [active] 266265011760 putative metal binding residues [ion binding]; other site 266265011761 signature motif; other site 266265011762 putative triphosphate binding site [ion binding]; other site 266265011763 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 266265011764 ligand binding site [chemical binding]; other site 266265011765 active site 266265011766 UGI interface [polypeptide binding]; other site 266265011767 catalytic site [active] 266265011768 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266265011769 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265011770 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 266265011771 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 266265011772 PDZ domain; Region: PDZ_2; pfam13180 266265011773 protein binding site [polypeptide binding]; other site 266265011774 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 266265011775 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 266265011776 dimerization domain [polypeptide binding]; other site 266265011777 dimer interface [polypeptide binding]; other site 266265011778 catalytic residues [active] 266265011779 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 266265011780 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 266265011781 GTP-binding protein YchF; Reviewed; Region: PRK09601 266265011782 YchF GTPase; Region: YchF; cd01900 266265011783 G1 box; other site 266265011784 GTP/Mg2+ binding site [chemical binding]; other site 266265011785 Switch I region; other site 266265011786 G2 box; other site 266265011787 Switch II region; other site 266265011788 G3 box; other site 266265011789 G4 box; other site 266265011790 G5 box; other site 266265011791 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 266265011792 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 266265011793 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 266265011794 putative active site [active] 266265011795 catalytic site [active] 266265011796 putative metal binding site [ion binding]; other site 266265011797 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266265011798 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 266265011799 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 266265011800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265011801 dimer interface [polypeptide binding]; other site 266265011802 conserved gate region; other site 266265011803 putative PBP binding loops; other site 266265011804 ABC-ATPase subunit interface; other site 266265011805 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266265011806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265011807 dimer interface [polypeptide binding]; other site 266265011808 conserved gate region; other site 266265011809 putative PBP binding loops; other site 266265011810 ABC-ATPase subunit interface; other site 266265011811 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266265011812 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266265011813 Walker A/P-loop; other site 266265011814 ATP binding site [chemical binding]; other site 266265011815 Q-loop/lid; other site 266265011816 ABC transporter signature motif; other site 266265011817 Walker B; other site 266265011818 D-loop; other site 266265011819 H-loop/switch region; other site 266265011820 TOBE domain; Region: TOBE_2; pfam08402 266265011821 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 266265011822 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 266265011823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265011824 Walker A/P-loop; other site 266265011825 ATP binding site [chemical binding]; other site 266265011826 Q-loop/lid; other site 266265011827 ABC transporter signature motif; other site 266265011828 Walker B; other site 266265011829 D-loop; other site 266265011830 H-loop/switch region; other site 266265011831 ABC transporter; Region: ABC_tran_2; pfam12848 266265011832 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265011833 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266265011834 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 266265011835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265011836 motif II; other site 266265011837 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266265011838 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 266265011839 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 266265011840 active site 266265011841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265011842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265011843 active site 266265011844 phosphorylation site [posttranslational modification] 266265011845 intermolecular recognition site; other site 266265011846 dimerization interface [polypeptide binding]; other site 266265011847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265011848 DNA binding site [nucleotide binding] 266265011849 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 266265011850 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 266265011851 tRNA; other site 266265011852 putative tRNA binding site [nucleotide binding]; other site 266265011853 putative NADP binding site [chemical binding]; other site 266265011854 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 266265011855 peptide chain release factor 1; Validated; Region: prfA; PRK00591 266265011856 This domain is found in peptide chain release factors; Region: PCRF; smart00937 266265011857 RF-1 domain; Region: RF-1; pfam00472 266265011858 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 266265011859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265011860 S-adenosylmethionine binding site [chemical binding]; other site 266265011861 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 266265011862 putative GSH binding site [chemical binding]; other site 266265011863 catalytic residues [active] 266265011864 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 266265011865 Flavoprotein; Region: Flavoprotein; pfam02441 266265011866 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 266265011867 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 266265011868 putative active site [active] 266265011869 metal binding site [ion binding]; metal-binding site 266265011870 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 266265011871 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266265011872 DNA-binding site [nucleotide binding]; DNA binding site 266265011873 RNA-binding motif; other site 266265011874 putative chaperone; Provisional; Region: PRK11678 266265011875 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 266265011876 nucleotide binding site [chemical binding]; other site 266265011877 putative NEF/HSP70 interaction site [polypeptide binding]; other site 266265011878 SBD interface [polypeptide binding]; other site 266265011879 benzoate transport; Region: 2A0115; TIGR00895 266265011880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265011881 putative substrate translocation pore; other site 266265011882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265011883 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 266265011884 putative FMN binding site [chemical binding]; other site 266265011885 D-galactonate transporter; Region: 2A0114; TIGR00893 266265011886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265011887 putative substrate translocation pore; other site 266265011888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265011889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265011890 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 266265011891 Methyltransferase domain; Region: Methyltransf_32; pfam13679 266265011892 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266265011893 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 266265011894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265011895 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 266265011896 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 266265011897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265011898 S-adenosylmethionine binding site [chemical binding]; other site 266265011899 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 266265011900 stringent starvation protein A; Provisional; Region: sspA; PRK09481 266265011901 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 266265011902 C-terminal domain interface [polypeptide binding]; other site 266265011903 putative GSH binding site (G-site) [chemical binding]; other site 266265011904 dimer interface [polypeptide binding]; other site 266265011905 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 266265011906 dimer interface [polypeptide binding]; other site 266265011907 N-terminal domain interface [polypeptide binding]; other site 266265011908 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 266265011909 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 266265011910 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 266265011911 Qi binding site; other site 266265011912 intrachain domain interface; other site 266265011913 interchain domain interface [polypeptide binding]; other site 266265011914 heme bH binding site [chemical binding]; other site 266265011915 heme bL binding site [chemical binding]; other site 266265011916 Qo binding site; other site 266265011917 interchain domain interface [polypeptide binding]; other site 266265011918 intrachain domain interface; other site 266265011919 Qi binding site; other site 266265011920 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 266265011921 Qo binding site; other site 266265011922 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 266265011923 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 266265011924 [2Fe-2S] cluster binding site [ion binding]; other site 266265011925 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 266265011926 Uncharacterized conserved protein [Function unknown]; Region: COG0327 266265011927 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266265011928 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266265011929 protein binding site [polypeptide binding]; other site 266265011930 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 266265011931 sec-independent translocase; Provisional; Region: tatB; PRK01919 266265011932 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 266265011933 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 266265011934 nucleotide binding site/active site [active] 266265011935 HIT family signature motif; other site 266265011936 catalytic residue [active] 266265011937 Predicted membrane protein [Function unknown]; Region: COG3671 266265011938 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 266265011939 metal binding site [ion binding]; metal-binding site 266265011940 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 266265011941 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 266265011942 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266265011943 substrate binding site [chemical binding]; other site 266265011944 glutamase interaction surface [polypeptide binding]; other site 266265011945 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 266265011946 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266265011947 catalytic residues [active] 266265011948 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 266265011949 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 266265011950 putative active site [active] 266265011951 oxyanion strand; other site 266265011952 catalytic triad [active] 266265011953 MarC family integral membrane protein; Region: MarC; cl00919 266265011954 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 266265011955 putative active site pocket [active] 266265011956 4-fold oligomerization interface [polypeptide binding]; other site 266265011957 metal binding residues [ion binding]; metal-binding site 266265011958 3-fold/trimer interface [polypeptide binding]; other site 266265011959 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 266265011960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265011961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265011962 homodimer interface [polypeptide binding]; other site 266265011963 catalytic residue [active] 266265011964 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 266265011965 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266265011966 NAD binding site [chemical binding]; other site 266265011967 dimerization interface [polypeptide binding]; other site 266265011968 product binding site; other site 266265011969 substrate binding site [chemical binding]; other site 266265011970 zinc binding site [ion binding]; other site 266265011971 catalytic residues [active] 266265011972 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 266265011973 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 266265011974 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 266265011975 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 266265011976 hinge; other site 266265011977 active site 266265011978 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 266265011979 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266265011980 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266265011981 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266265011982 Walker A/P-loop; other site 266265011983 ATP binding site [chemical binding]; other site 266265011984 Q-loop/lid; other site 266265011985 ABC transporter signature motif; other site 266265011986 Walker B; other site 266265011987 D-loop; other site 266265011988 H-loop/switch region; other site 266265011989 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 266265011990 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 266265011991 VacJ like lipoprotein; Region: VacJ; cl01073 266265011992 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 266265011993 mce related protein; Region: MCE; pfam02470 266265011994 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 266265011995 Permease; Region: Permease; pfam02405 266265011996 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 266265011997 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 266265011998 Walker A/P-loop; other site 266265011999 ATP binding site [chemical binding]; other site 266265012000 Q-loop/lid; other site 266265012001 ABC transporter signature motif; other site 266265012002 Walker B; other site 266265012003 D-loop; other site 266265012004 H-loop/switch region; other site 266265012005 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 266265012006 thiamine phosphate binding site [chemical binding]; other site 266265012007 active site 266265012008 pyrophosphate binding site [ion binding]; other site 266265012009 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 266265012010 ThiS interaction site; other site 266265012011 putative active site [active] 266265012012 tetramer interface [polypeptide binding]; other site 266265012013 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 266265012014 thiS-thiF/thiG interaction site; other site 266265012015 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 266265012016 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 266265012017 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266265012018 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 266265012019 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 266265012020 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 266265012021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265012022 NAD(P) binding site [chemical binding]; other site 266265012023 active site 266265012024 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266265012025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265012026 active site 266265012027 phosphorylation site [posttranslational modification] 266265012028 intermolecular recognition site; other site 266265012029 dimerization interface [polypeptide binding]; other site 266265012030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265012031 DNA binding site [nucleotide binding] 266265012032 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 266265012033 Flagellar L-ring protein; Region: FlgH; pfam02107 266265012034 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266265012035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265012036 active site 266265012037 phosphorylation site [posttranslational modification] 266265012038 intermolecular recognition site; other site 266265012039 dimerization interface [polypeptide binding]; other site 266265012040 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265012041 DNA binding site [nucleotide binding] 266265012042 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265012043 dimerization interface [polypeptide binding]; other site 266265012044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265012045 dimer interface [polypeptide binding]; other site 266265012046 phosphorylation site [posttranslational modification] 266265012047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265012048 ATP binding site [chemical binding]; other site 266265012049 Mg2+ binding site [ion binding]; other site 266265012050 G-X-G motif; other site 266265012051 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 266265012052 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 266265012053 benzoate transport; Region: 2A0115; TIGR00895 266265012054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265012055 putative substrate translocation pore; other site 266265012056 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 266265012057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265012058 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265012059 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 266265012060 putative active site [active] 266265012061 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 266265012062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265012063 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 266265012064 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 266265012065 active site 266265012066 dimer interface [polypeptide binding]; other site 266265012067 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 266265012068 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 266265012069 active site 266265012070 FMN binding site [chemical binding]; other site 266265012071 substrate binding site [chemical binding]; other site 266265012072 3Fe-4S cluster binding site [ion binding]; other site 266265012073 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 266265012074 domain interface; other site 266265012075 Transposase IS200 like; Region: Y1_Tnp; cl00848 266265012076 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 266265012077 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 266265012078 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 266265012079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266265012080 Zn2+ binding site [ion binding]; other site 266265012081 Mg2+ binding site [ion binding]; other site 266265012082 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 266265012083 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 266265012084 active site 266265012085 dimer interface [polypeptide binding]; other site 266265012086 metal binding site [ion binding]; metal-binding site 266265012087 shikimate kinase; Reviewed; Region: aroK; PRK00131 266265012088 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266265012089 ADP binding site [chemical binding]; other site 266265012090 magnesium binding site [ion binding]; other site 266265012091 putative shikimate binding site; other site 266265012092 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 266265012093 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266265012094 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266265012095 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 266265012096 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 266265012097 Transglycosylase; Region: Transgly; pfam00912 266265012098 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266265012099 frataxin-like protein; Provisional; Region: cyaY; PRK00446 266265012100 diaminopimelate decarboxylase; Region: lysA; TIGR01048 266265012101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 266265012102 active site 266265012103 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266265012104 substrate binding site [chemical binding]; other site 266265012105 catalytic residues [active] 266265012106 dimer interface [polypeptide binding]; other site 266265012107 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 266265012108 TMAO/DMSO reductase; Reviewed; Region: PRK05363 266265012109 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 266265012110 Moco binding site; other site 266265012111 metal coordination site [ion binding]; other site 266265012112 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 266265012113 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 266265012114 ResB-like family; Region: ResB; pfam05140 266265012115 Cytochrome c553 [Energy production and conversion]; Region: COG2863 266265012116 Cytochrome c; Region: Cytochrom_C; cl11414 266265012117 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 266265012118 G1 box; other site 266265012119 GTP/Mg2+ binding site [chemical binding]; other site 266265012120 Switch I region; other site 266265012121 G2 box; other site 266265012122 G3 box; other site 266265012123 Switch II region; other site 266265012124 G4 box; other site 266265012125 G5 box; other site 266265012126 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 266265012127 dimer interface [polypeptide binding]; other site 266265012128 active site 266265012129 aspartate-rich active site metal binding site; other site 266265012130 allosteric magnesium binding site [ion binding]; other site 266265012131 Schiff base residues; other site 266265012132 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 266265012133 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 266265012134 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266265012135 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 266265012136 DsbD alpha interface [polypeptide binding]; other site 266265012137 catalytic residues [active] 266265012138 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 266265012139 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 266265012140 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 266265012141 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 266265012142 alphaNTD homodimer interface [polypeptide binding]; other site 266265012143 alphaNTD - beta interaction site [polypeptide binding]; other site 266265012144 alphaNTD - beta' interaction site [polypeptide binding]; other site 266265012145 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 266265012146 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 266265012147 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 266265012148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 266265012149 RNA binding surface [nucleotide binding]; other site 266265012150 30S ribosomal protein S11; Validated; Region: PRK05309 266265012151 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 266265012152 30S ribosomal protein S13; Region: bact_S13; TIGR03631 266265012153 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 266265012154 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266265012155 rRNA binding site [nucleotide binding]; other site 266265012156 predicted 30S ribosome binding site; other site 266265012157 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 266265012158 SecY translocase; Region: SecY; pfam00344 266265012159 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 266265012160 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 266265012161 23S rRNA binding site [nucleotide binding]; other site 266265012162 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 266265012163 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 266265012164 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 266265012165 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 266265012166 5S rRNA interface [nucleotide binding]; other site 266265012167 L27 interface [polypeptide binding]; other site 266265012168 23S rRNA interface [nucleotide binding]; other site 266265012169 L5 interface [polypeptide binding]; other site 266265012170 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 266265012171 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266265012172 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 266265012173 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 266265012174 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 266265012175 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 266265012176 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 266265012177 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 266265012178 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 266265012179 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 266265012180 RNA binding site [nucleotide binding]; other site 266265012181 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 266265012182 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 266265012183 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 266265012184 23S rRNA interface [nucleotide binding]; other site 266265012185 putative translocon interaction site; other site 266265012186 signal recognition particle (SRP54) interaction site; other site 266265012187 L23 interface [polypeptide binding]; other site 266265012188 trigger factor interaction site; other site 266265012189 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 266265012190 23S rRNA interface [nucleotide binding]; other site 266265012191 5S rRNA interface [nucleotide binding]; other site 266265012192 putative antibiotic binding site [chemical binding]; other site 266265012193 L25 interface [polypeptide binding]; other site 266265012194 L27 interface [polypeptide binding]; other site 266265012195 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 266265012196 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 266265012197 G-X-X-G motif; other site 266265012198 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 266265012199 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 266265012200 putative translocon binding site; other site 266265012201 protein-rRNA interface [nucleotide binding]; other site 266265012202 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 266265012203 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 266265012204 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 266265012205 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 266265012206 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 266265012207 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 266265012208 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 266265012209 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 266265012210 elongation factor Tu; Reviewed; Region: PRK00049 266265012211 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266265012212 G1 box; other site 266265012213 GEF interaction site [polypeptide binding]; other site 266265012214 GTP/Mg2+ binding site [chemical binding]; other site 266265012215 Switch I region; other site 266265012216 G2 box; other site 266265012217 G3 box; other site 266265012218 Switch II region; other site 266265012219 G4 box; other site 266265012220 G5 box; other site 266265012221 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266265012222 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266265012223 Antibiotic Binding Site [chemical binding]; other site 266265012224 elongation factor G; Reviewed; Region: PRK00007 266265012225 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 266265012226 G1 box; other site 266265012227 putative GEF interaction site [polypeptide binding]; other site 266265012228 GTP/Mg2+ binding site [chemical binding]; other site 266265012229 Switch I region; other site 266265012230 G2 box; other site 266265012231 G3 box; other site 266265012232 Switch II region; other site 266265012233 G4 box; other site 266265012234 G5 box; other site 266265012235 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 266265012236 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 266265012237 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 266265012238 30S ribosomal protein S7; Validated; Region: PRK05302 266265012239 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 266265012240 S17 interaction site [polypeptide binding]; other site 266265012241 S8 interaction site; other site 266265012242 16S rRNA interaction site [nucleotide binding]; other site 266265012243 streptomycin interaction site [chemical binding]; other site 266265012244 23S rRNA interaction site [nucleotide binding]; other site 266265012245 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 266265012246 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 266265012247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265012248 ATP binding site [chemical binding]; other site 266265012249 putative Mg++ binding site [ion binding]; other site 266265012250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265012251 nucleotide binding region [chemical binding]; other site 266265012252 ATP-binding site [chemical binding]; other site 266265012253 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 266265012254 HRDC domain; Region: HRDC; pfam00570 266265012255 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 266265012256 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 266265012257 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 266265012258 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 266265012259 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 266265012260 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 266265012261 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 266265012262 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 266265012263 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 266265012264 DNA binding site [nucleotide binding] 266265012265 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 266265012266 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 266265012267 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 266265012268 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 266265012269 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266265012270 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 266265012271 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 266265012272 RPB3 interaction site [polypeptide binding]; other site 266265012273 RPB1 interaction site [polypeptide binding]; other site 266265012274 RPB11 interaction site [polypeptide binding]; other site 266265012275 RPB10 interaction site [polypeptide binding]; other site 266265012276 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 266265012277 peripheral dimer interface [polypeptide binding]; other site 266265012278 core dimer interface [polypeptide binding]; other site 266265012279 L10 interface [polypeptide binding]; other site 266265012280 L11 interface [polypeptide binding]; other site 266265012281 putative EF-Tu interaction site [polypeptide binding]; other site 266265012282 putative EF-G interaction site [polypeptide binding]; other site 266265012283 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 266265012284 23S rRNA interface [nucleotide binding]; other site 266265012285 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 266265012286 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 266265012287 mRNA/rRNA interface [nucleotide binding]; other site 266265012288 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 266265012289 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 266265012290 23S rRNA interface [nucleotide binding]; other site 266265012291 L7/L12 interface [polypeptide binding]; other site 266265012292 putative thiostrepton binding site; other site 266265012293 L25 interface [polypeptide binding]; other site 266265012294 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 266265012295 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 266265012296 putative homodimer interface [polypeptide binding]; other site 266265012297 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 266265012298 heterodimer interface [polypeptide binding]; other site 266265012299 homodimer interface [polypeptide binding]; other site 266265012300 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 266265012301 elongation factor Tu; Reviewed; Region: PRK00049 266265012302 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 266265012303 G1 box; other site 266265012304 GEF interaction site [polypeptide binding]; other site 266265012305 GTP/Mg2+ binding site [chemical binding]; other site 266265012306 Switch I region; other site 266265012307 G2 box; other site 266265012308 G3 box; other site 266265012309 Switch II region; other site 266265012310 G4 box; other site 266265012311 G5 box; other site 266265012312 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 266265012313 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 266265012314 Antibiotic Binding Site [chemical binding]; other site 266265012315 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 266265012316 active site 266265012317 catalytic triad [active] 266265012318 oxyanion hole [active] 266265012319 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 266265012320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265012321 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 266265012322 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 266265012323 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 266265012324 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 266265012325 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 266265012326 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 266265012327 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 266265012328 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 266265012329 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 266265012330 FAD binding pocket [chemical binding]; other site 266265012331 FAD binding motif [chemical binding]; other site 266265012332 phosphate binding motif [ion binding]; other site 266265012333 beta-alpha-beta structure motif; other site 266265012334 NAD(p) ribose binding residues [chemical binding]; other site 266265012335 NAD binding pocket [chemical binding]; other site 266265012336 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 266265012337 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265012338 catalytic loop [active] 266265012339 iron binding site [ion binding]; other site 266265012340 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 266265012341 Protein of unknown function; Region: DUF3658; pfam12395 266265012342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265012343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265012344 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266265012345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265012346 Coenzyme A binding pocket [chemical binding]; other site 266265012347 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265012348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265012349 putative DNA binding site [nucleotide binding]; other site 266265012350 putative Zn2+ binding site [ion binding]; other site 266265012351 AsnC family; Region: AsnC_trans_reg; pfam01037 266265012352 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 266265012353 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 266265012354 dimer interface [polypeptide binding]; other site 266265012355 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266265012356 active site 266265012357 Fe binding site [ion binding]; other site 266265012358 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 266265012359 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266265012360 dimer interface [polypeptide binding]; other site 266265012361 PYR/PP interface [polypeptide binding]; other site 266265012362 TPP binding site [chemical binding]; other site 266265012363 substrate binding site [chemical binding]; other site 266265012364 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 266265012365 TPP-binding site; other site 266265012366 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 266265012367 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 266265012368 Malic enzyme, N-terminal domain; Region: malic; pfam00390 266265012369 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 266265012370 putative NAD(P) binding site [chemical binding]; other site 266265012371 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 266265012372 benzoate transport; Region: 2A0115; TIGR00895 266265012373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265012374 putative substrate translocation pore; other site 266265012375 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265012376 active site 266265012377 transcriptional regulator RcsB; Provisional; Region: PRK10840 266265012378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265012379 active site 266265012380 phosphorylation site [posttranslational modification] 266265012381 intermolecular recognition site; other site 266265012382 dimerization interface [polypeptide binding]; other site 266265012383 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265012384 DNA binding residues [nucleotide binding] 266265012385 dimerization interface [polypeptide binding]; other site 266265012386 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 266265012387 substrate binding site [chemical binding]; other site 266265012388 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 266265012389 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265012390 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 266265012391 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266265012392 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 266265012393 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 266265012394 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 266265012395 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265012396 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265012397 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265012398 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 266265012399 Uncharacterized conserved protein [Function unknown]; Region: COG1656 266265012400 Protein of unknown function DUF82; Region: DUF82; pfam01927 266265012401 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266265012402 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265012403 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265012404 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266265012405 EamA-like transporter family; Region: EamA; pfam00892 266265012406 EamA-like transporter family; Region: EamA; pfam00892 266265012407 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 266265012408 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266265012409 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265012410 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265012411 catalytic residue [active] 266265012412 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 266265012413 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265012414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265012415 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265012416 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265012417 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265012418 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265012419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265012420 Transposase; Region: HTH_Tnp_1; pfam01527 266265012421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265012422 DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242 266265012423 AAA domain; Region: AAA_22; pfam13401 266265012424 Response regulator receiver domain; Region: Response_reg; pfam00072 266265012425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265012426 active site 266265012427 phosphorylation site [posttranslational modification] 266265012428 intermolecular recognition site; other site 266265012429 dimerization interface [polypeptide binding]; other site 266265012430 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266265012431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265012432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265012433 dimer interface [polypeptide binding]; other site 266265012434 phosphorylation site [posttranslational modification] 266265012435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265012436 ATP binding site [chemical binding]; other site 266265012437 Mg2+ binding site [ion binding]; other site 266265012438 G-X-G motif; other site 266265012439 Response regulator receiver domain; Region: Response_reg; pfam00072 266265012440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265012441 active site 266265012442 phosphorylation site [posttranslational modification] 266265012443 intermolecular recognition site; other site 266265012444 dimerization interface [polypeptide binding]; other site 266265012445 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266265012446 metal-binding site [ion binding] 266265012447 MerT mercuric transport protein; Region: MerT; cl03578 266265012448 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 266265012449 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266265012450 DNA binding residues [nucleotide binding] 266265012451 dimer interface [polypeptide binding]; other site 266265012452 mercury binding site [ion binding]; other site 266265012453 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266265012454 classical (c) SDRs; Region: SDR_c; cd05233 266265012455 NAD(P) binding site [chemical binding]; other site 266265012456 active site 266265012457 xylulokinase; Provisional; Region: PRK15027 266265012458 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 266265012459 N- and C-terminal domain interface [polypeptide binding]; other site 266265012460 active site 266265012461 MgATP binding site [chemical binding]; other site 266265012462 catalytic site [active] 266265012463 metal binding site [ion binding]; metal-binding site 266265012464 xylulose binding site [chemical binding]; other site 266265012465 homodimer interface [polypeptide binding]; other site 266265012466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265012467 non-specific DNA binding site [nucleotide binding]; other site 266265012468 salt bridge; other site 266265012469 sequence-specific DNA binding site [nucleotide binding]; other site 266265012470 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265012471 non-specific DNA binding site [nucleotide binding]; other site 266265012472 salt bridge; other site 266265012473 sequence-specific DNA binding site [nucleotide binding]; other site 266265012474 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266265012475 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266265012476 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 266265012477 HsdM N-terminal domain; Region: HsdM_N; pfam12161 266265012478 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 266265012479 Methyltransferase domain; Region: Methyltransf_26; pfam13659 266265012480 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 266265012481 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 266265012482 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 266265012483 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 266265012484 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 266265012485 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 266265012486 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265012487 ATP binding site [chemical binding]; other site 266265012488 putative Mg++ binding site [ion binding]; other site 266265012489 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 266265012490 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 266265012491 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 266265012492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 266265012493 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 266265012494 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 266265012495 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 266265012496 dimerization interface [polypeptide binding]; other site 266265012497 active site 266265012498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266265012499 Domain of unknown function (DUF955); Region: DUF955; pfam06114 266265012500 Helix-turn-helix domain; Region: HTH_39; pfam14090 266265012501 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 266265012502 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 266265012503 glutaminase active site [active] 266265012504 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 266265012505 dimer interface [polypeptide binding]; other site 266265012506 active site 266265012507 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 266265012508 dimer interface [polypeptide binding]; other site 266265012509 active site 266265012510 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 266265012511 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 266265012512 Substrate binding site; other site 266265012513 Mg++ binding site; other site 266265012514 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 266265012515 active site 266265012516 substrate binding site [chemical binding]; other site 266265012517 CoA binding site [chemical binding]; other site 266265012518 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 266265012519 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 266265012520 Ligand Binding Site [chemical binding]; other site 266265012521 Dihydroneopterin aldolase; Region: FolB; smart00905 266265012522 active site 266265012523 short chain dehydrogenase; Provisional; Region: PRK09134 266265012524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265012525 NAD(P) binding site [chemical binding]; other site 266265012526 active site 266265012527 Uncharacterized conserved protein [Function unknown]; Region: COG1565 266265012528 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 266265012529 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 266265012530 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 266265012531 active site 266265012532 NTP binding site [chemical binding]; other site 266265012533 metal binding triad [ion binding]; metal-binding site 266265012534 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 266265012535 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 266265012536 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265012537 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 266265012538 putative C-terminal domain interface [polypeptide binding]; other site 266265012539 putative GSH binding site (G-site) [chemical binding]; other site 266265012540 putative dimer interface [polypeptide binding]; other site 266265012541 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 266265012542 putative substrate binding pocket (H-site) [chemical binding]; other site 266265012543 putative N-terminal domain interface [polypeptide binding]; other site 266265012544 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 266265012545 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 266265012546 putative NAD(P) binding site [chemical binding]; other site 266265012547 active site 266265012548 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266265012549 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265012550 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265012551 catalytic residue [active] 266265012552 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 266265012553 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 266265012554 MarR family; Region: MarR_2; cl17246 266265012555 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 266265012556 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 266265012557 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 266265012558 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 266265012559 putative active site [active] 266265012560 Protein of unknown function (DUF969); Region: DUF969; pfam06149 266265012561 Predicted membrane protein [Function unknown]; Region: COG3817 266265012562 Protein of unknown function (DUF979); Region: DUF979; pfam06166 266265012563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265012564 binding surface 266265012565 TPR repeat; Region: TPR_11; pfam13414 266265012566 TPR motif; other site 266265012567 TPR repeat; Region: TPR_11; pfam13414 266265012568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265012569 binding surface 266265012570 TPR motif; other site 266265012571 TPR repeat; Region: TPR_11; pfam13414 266265012572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265012573 binding surface 266265012574 TPR motif; other site 266265012575 TPR repeat; Region: TPR_11; pfam13414 266265012576 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265012577 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 266265012578 Protein of unknown function (DUF497); Region: DUF497; pfam04365 266265012579 TraB family; Region: TraB; pfam01963 266265012580 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 266265012581 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265012582 Walker A/P-loop; other site 266265012583 ATP binding site [chemical binding]; other site 266265012584 Q-loop/lid; other site 266265012585 ABC transporter signature motif; other site 266265012586 Walker B; other site 266265012587 D-loop; other site 266265012588 H-loop/switch region; other site 266265012589 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266265012590 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266265012591 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265012592 Walker A/P-loop; other site 266265012593 ATP binding site [chemical binding]; other site 266265012594 Q-loop/lid; other site 266265012595 ABC transporter signature motif; other site 266265012596 Walker B; other site 266265012597 D-loop; other site 266265012598 H-loop/switch region; other site 266265012599 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265012600 dipeptide transporter; Provisional; Region: PRK10913 266265012601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265012602 dimer interface [polypeptide binding]; other site 266265012603 conserved gate region; other site 266265012604 putative PBP binding loops; other site 266265012605 ABC-ATPase subunit interface; other site 266265012606 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266265012607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265012608 dimer interface [polypeptide binding]; other site 266265012609 conserved gate region; other site 266265012610 putative PBP binding loops; other site 266265012611 ABC-ATPase subunit interface; other site 266265012612 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265012613 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 266265012614 peptide binding site [polypeptide binding]; other site 266265012615 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265012616 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 266265012617 peptide binding site [polypeptide binding]; other site 266265012618 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 266265012619 FAD binding site [chemical binding]; other site 266265012620 Predicted membrane protein [Function unknown]; Region: COG1950 266265012621 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 266265012622 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 266265012623 homotetramer interface [polypeptide binding]; other site 266265012624 ligand binding site [chemical binding]; other site 266265012625 catalytic site [active] 266265012626 NAD binding site [chemical binding]; other site 266265012627 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266265012628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 266265012629 active site 266265012630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265012631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265012632 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 266265012633 putative dimerization interface [polypeptide binding]; other site 266265012634 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 266265012635 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265012636 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 266265012637 ligand binding site [chemical binding]; other site 266265012638 choline dehydrogenase; Validated; Region: PRK02106 266265012639 lycopene cyclase; Region: lycopene_cycl; TIGR01789 266265012640 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265012641 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 266265012642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265012643 active site 266265012644 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 266265012645 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 266265012646 NAD(P) binding site [chemical binding]; other site 266265012647 catalytic residues [active] 266265012648 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 266265012649 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 266265012650 Flagellar protein FliT; Region: FliT; cl05125 266265012651 Flagellar protein FliT; Region: FliT; pfam05400 266265012652 flagellar protein FliS; Validated; Region: fliS; PRK05685 266265012653 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 266265012654 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 266265012655 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 266265012656 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 266265012657 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 266265012658 FliG C-terminal domain; Region: FliG_C; pfam01706 266265012659 flagellar assembly protein H; Validated; Region: fliH; PRK05687 266265012660 Flagellar assembly protein FliH; Region: FliH; pfam02108 266265012661 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 266265012662 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 266265012663 Walker A motif/ATP binding site; other site 266265012664 Walker B motif; other site 266265012665 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 266265012666 Flagellar FliJ protein; Region: FliJ; pfam02050 266265012667 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 266265012668 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 266265012669 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 266265012670 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 266265012671 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 266265012672 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 266265012673 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 266265012674 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 266265012675 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 266265012676 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 266265012677 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 266265012678 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266265012679 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 266265012680 Flagellar regulator YcgR; Region: YcgR; pfam07317 266265012681 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 266265012682 PilZ domain; Region: PilZ; pfam07238 266265012683 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 266265012684 Rod binding protein; Region: Rod-binding; cl01626 266265012685 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 266265012686 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 266265012687 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 266265012688 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 266265012689 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 266265012690 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 266265012691 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266265012692 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266265012693 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 266265012694 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266265012695 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 266265012696 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 266265012697 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266265012698 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 266265012699 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 266265012700 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 266265012701 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 266265012702 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 266265012703 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 266265012704 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 266265012705 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 266265012706 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 266265012707 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 266265012708 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 266265012709 FlgN protein; Region: FlgN; pfam05130 266265012710 YcfA-like protein; Region: YcfA; pfam07927 266265012711 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 266265012712 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 266265012713 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 266265012714 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265012715 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266265012716 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265012717 DNA binding residues [nucleotide binding] 266265012718 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 266265012719 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265012720 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265012721 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 266265012722 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265012723 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 266265012724 FHIPEP family; Region: FHIPEP; pfam00771 266265012725 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 266265012726 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 266265012727 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 266265012728 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 266265012729 chemotaxis regulator CheZ; Provisional; Region: PRK11166 266265012730 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 266265012731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265012732 active site 266265012733 phosphorylation site [posttranslational modification] 266265012734 intermolecular recognition site; other site 266265012735 dimerization interface [polypeptide binding]; other site 266265012736 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 266265012737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265012738 active site 266265012739 phosphorylation site [posttranslational modification] 266265012740 intermolecular recognition site; other site 266265012741 dimerization interface [polypeptide binding]; other site 266265012742 CheB methylesterase; Region: CheB_methylest; pfam01339 266265012743 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 266265012744 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 266265012745 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 266265012746 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 266265012747 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 266265012748 dimer interface [polypeptide binding]; other site 266265012749 ligand binding site [chemical binding]; other site 266265012750 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265012751 dimerization interface [polypeptide binding]; other site 266265012752 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265012753 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265012754 dimer interface [polypeptide binding]; other site 266265012755 putative CheW interface [polypeptide binding]; other site 266265012756 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 266265012757 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266265012758 putative binding surface; other site 266265012759 active site 266265012760 CheY binding; Region: CheY-binding; pfam09078 266265012761 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 266265012762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265012763 ATP binding site [chemical binding]; other site 266265012764 Mg2+ binding site [ion binding]; other site 266265012765 G-X-G motif; other site 266265012766 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 266265012767 Response regulator receiver domain; Region: Response_reg; pfam00072 266265012768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265012769 active site 266265012770 phosphorylation site [posttranslational modification] 266265012771 intermolecular recognition site; other site 266265012772 dimerization interface [polypeptide binding]; other site 266265012773 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 266265012774 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 266265012775 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265012776 ligand binding site [chemical binding]; other site 266265012777 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 266265012778 flagellar motor protein MotA; Validated; Region: PRK09110 266265012779 transcriptional activator FlhC; Provisional; Region: PRK12722 266265012780 transcriptional activator FlhD; Provisional; Region: PRK02909 266265012781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265012782 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266265012783 putative ADP-binding pocket [chemical binding]; other site 266265012784 H-NS histone family; Region: Histone_HNS; pfam00816 266265012785 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266265012786 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 266265012787 amphipathic channel; other site 266265012788 Asn-Pro-Ala signature motifs; other site 266265012789 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 266265012790 putative hydrolase; Provisional; Region: PRK10976 266265012791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265012792 active site 266265012793 motif I; other site 266265012794 motif II; other site 266265012795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265012796 motif II; other site 266265012797 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266265012798 nucleotide binding site [chemical binding]; other site 266265012799 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 266265012800 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 266265012801 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265012802 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265012803 active site 266265012804 catalytic tetrad [active] 266265012805 flagellin; Reviewed; Region: PRK08869 266265012806 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 266265012807 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 266265012808 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 266265012809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265012810 TPR motif; other site 266265012811 binding surface 266265012812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265012813 binding surface 266265012814 TPR motif; other site 266265012815 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 266265012816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265012817 TPR motif; other site 266265012818 binding surface 266265012819 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 266265012820 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266265012821 inhibitor-cofactor binding pocket; inhibition site 266265012822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265012823 catalytic residue [active] 266265012824 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266265012825 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266265012826 dimer interface [polypeptide binding]; other site 266265012827 active site 266265012828 CoA binding pocket [chemical binding]; other site 266265012829 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 266265012830 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 266265012831 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 266265012832 dimer interface [polypeptide binding]; other site 266265012833 active site 266265012834 CoA binding pocket [chemical binding]; other site 266265012835 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265012836 classical (c) SDRs; Region: SDR_c; cd05233 266265012837 NAD(P) binding site [chemical binding]; other site 266265012838 active site 266265012839 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 266265012840 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 266265012841 putative trimer interface [polypeptide binding]; other site 266265012842 putative CoA binding site [chemical binding]; other site 266265012843 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265012844 [2Fe-2S] cluster binding site [ion binding]; other site 266265012845 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 266265012846 alpha subunit interface [polypeptide binding]; other site 266265012847 active site 266265012848 substrate binding site [chemical binding]; other site 266265012849 Fe binding site [ion binding]; other site 266265012850 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 266265012851 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 266265012852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265012853 motif II; other site 266265012854 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 266265012855 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 266265012856 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 266265012857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265012858 non-specific DNA binding site [nucleotide binding]; other site 266265012859 salt bridge; other site 266265012860 sequence-specific DNA binding site [nucleotide binding]; other site 266265012861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265012862 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266265012863 Walker A motif; other site 266265012864 ATP binding site [chemical binding]; other site 266265012865 Walker B motif; other site 266265012866 arginine finger; other site 266265012867 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 266265012868 active site 266265012869 catalytic triad [active] 266265012870 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 266265012871 metal binding triad [ion binding]; metal-binding site 266265012872 Integrase core domain; Region: rve; pfam00665 266265012873 transposase; Validated; Region: PRK08181 266265012874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265012875 Walker A motif; other site 266265012876 ATP binding site [chemical binding]; other site 266265012877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265012878 Transposase; Region: HTH_Tnp_1; pfam01527 266265012879 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265012880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265012881 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265012882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265012883 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265012884 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265012885 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265012886 TniQ; Region: TniQ; pfam06527 266265012887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265012888 Helix-turn-helix domain; Region: HTH_28; pfam13518 266265012889 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 266265012890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265012891 Walker A motif; other site 266265012892 ATP binding site [chemical binding]; other site 266265012893 Walker B motif; other site 266265012894 arginine finger; other site 266265012895 Helix-turn-helix domain; Region: HTH_38; pfam13936 266265012896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 266265012897 Integrase core domain; Region: rve; pfam00665 266265012898 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265012899 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266265012900 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266265012901 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265012902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265012903 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265012904 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265012905 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265012906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265012907 Transposase; Region: HTH_Tnp_1; pfam01527 266265012908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266265012909 sequence-specific DNA binding site [nucleotide binding]; other site 266265012910 salt bridge; other site 266265012911 Cytochrome c; Region: Cytochrom_C; cl11414 266265012912 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265012913 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 266265012914 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 266265012915 Part of AAA domain; Region: AAA_19; pfam13245 266265012916 Family description; Region: UvrD_C_2; pfam13538 266265012917 putative oxidoreductase; Provisional; Region: PRK11579 266265012918 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266265012919 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 266265012920 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 266265012921 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266265012922 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 266265012923 lipoyl attachment site [posttranslational modification]; other site 266265012924 glycine dehydrogenase; Provisional; Region: PRK05367 266265012925 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266265012926 tetramer interface [polypeptide binding]; other site 266265012927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265012928 catalytic residue [active] 266265012929 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 266265012930 tetramer interface [polypeptide binding]; other site 266265012931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265012932 catalytic residue [active] 266265012933 Alginate lyase; Region: Alginate_lyase; pfam05426 266265012934 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266265012935 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266265012936 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 266265012937 thiamine pyrophosphate protein; Validated; Region: PRK08199 266265012938 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265012939 PYR/PP interface [polypeptide binding]; other site 266265012940 dimer interface [polypeptide binding]; other site 266265012941 TPP binding site [chemical binding]; other site 266265012942 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265012943 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266265012944 TPP-binding site [chemical binding]; other site 266265012945 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265012946 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266265012947 dimerization interface [polypeptide binding]; other site 266265012948 ligand binding site [chemical binding]; other site 266265012949 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 266265012950 Predicted transcriptional regulator [Transcription]; Region: COG3905 266265012951 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 266265012952 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 266265012953 Glutamate binding site [chemical binding]; other site 266265012954 NAD binding site [chemical binding]; other site 266265012955 catalytic residues [active] 266265012956 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265012957 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 266265012958 primosome assembly protein PriA; Validated; Region: PRK05580 266265012959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265012960 ATP binding site [chemical binding]; other site 266265012961 putative Mg++ binding site [ion binding]; other site 266265012962 helicase superfamily c-terminal domain; Region: HELICc; smart00490 266265012963 ATP-binding site [chemical binding]; other site 266265012964 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 266265012965 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 266265012966 substrate binding site [chemical binding]; other site 266265012967 active site 266265012968 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265012969 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265012970 substrate binding pocket [chemical binding]; other site 266265012971 membrane-bound complex binding site; other site 266265012972 hinge residues; other site 266265012973 AMP-binding domain protein; Validated; Region: PRK08315 266265012974 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265012975 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 266265012976 acyl-activating enzyme (AAE) consensus motif; other site 266265012977 putative AMP binding site [chemical binding]; other site 266265012978 putative active site [active] 266265012979 putative CoA binding site [chemical binding]; other site 266265012980 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 266265012981 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 266265012982 gamma subunit interface [polypeptide binding]; other site 266265012983 epsilon subunit interface [polypeptide binding]; other site 266265012984 LBP interface [polypeptide binding]; other site 266265012985 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 266265012986 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266265012987 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266265012988 alpha subunit interaction interface [polypeptide binding]; other site 266265012989 Walker A motif; other site 266265012990 ATP binding site [chemical binding]; other site 266265012991 Walker B motif; other site 266265012992 inhibitor binding site; inhibition site 266265012993 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266265012994 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 266265012995 core domain interface [polypeptide binding]; other site 266265012996 delta subunit interface [polypeptide binding]; other site 266265012997 epsilon subunit interface [polypeptide binding]; other site 266265012998 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 266265012999 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266265013000 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 266265013001 beta subunit interaction interface [polypeptide binding]; other site 266265013002 Walker A motif; other site 266265013003 ATP binding site [chemical binding]; other site 266265013004 Walker B motif; other site 266265013005 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266265013006 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 266265013007 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 266265013008 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 266265013009 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 266265013010 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 266265013011 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 266265013012 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 266265013013 ATP synthase I chain; Region: ATP_synt_I; cl09170 266265013014 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 266265013015 ParB-like nuclease domain; Region: ParBc; pfam02195 266265013016 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266265013017 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265013018 P-loop; other site 266265013019 Magnesium ion binding site [ion binding]; other site 266265013020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265013021 Magnesium ion binding site [ion binding]; other site 266265013022 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 266265013023 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 266265013024 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 266265013025 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 266265013026 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 266265013027 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 266265013028 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265013029 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265013030 Walker A/P-loop; other site 266265013031 ATP binding site [chemical binding]; other site 266265013032 Q-loop/lid; other site 266265013033 ABC transporter signature motif; other site 266265013034 Walker B; other site 266265013035 D-loop; other site 266265013036 H-loop/switch region; other site 266265013037 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265013038 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265013039 TM-ABC transporter signature motif; other site 266265013040 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265013041 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265013042 Walker A/P-loop; other site 266265013043 ATP binding site [chemical binding]; other site 266265013044 Q-loop/lid; other site 266265013045 ABC transporter signature motif; other site 266265013046 Walker B; other site 266265013047 D-loop; other site 266265013048 H-loop/switch region; other site 266265013049 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265013050 TM-ABC transporter signature motif; other site 266265013051 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265013052 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 266265013053 putative ligand binding site [chemical binding]; other site 266265013054 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265013055 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 266265013056 putative ligand binding site [chemical binding]; other site 266265013057 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265013058 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265013059 TM-ABC transporter signature motif; other site 266265013060 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265013061 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265013062 TM-ABC transporter signature motif; other site 266265013063 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265013064 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266265013065 putative ligand binding site [chemical binding]; other site 266265013066 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265013067 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265013068 Walker A/P-loop; other site 266265013069 ATP binding site [chemical binding]; other site 266265013070 Q-loop/lid; other site 266265013071 ABC transporter signature motif; other site 266265013072 Walker B; other site 266265013073 D-loop; other site 266265013074 H-loop/switch region; other site 266265013075 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265013076 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265013077 Walker A/P-loop; other site 266265013078 ATP binding site [chemical binding]; other site 266265013079 Q-loop/lid; other site 266265013080 ABC transporter signature motif; other site 266265013081 Walker B; other site 266265013082 D-loop; other site 266265013083 H-loop/switch region; other site 266265013084 choline dehydrogenase; Validated; Region: PRK02106 266265013085 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265013086 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266265013087 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266265013088 tetrameric interface [polypeptide binding]; other site 266265013089 NAD binding site [chemical binding]; other site 266265013090 catalytic residues [active] 266265013091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265013092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265013093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265013094 dimerization interface [polypeptide binding]; other site 266265013095 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 266265013096 putative active site [active] 266265013097 putative metal binding residues [ion binding]; other site 266265013098 signature motif; other site 266265013099 putative triphosphate binding site [ion binding]; other site 266265013100 dimer interface [polypeptide binding]; other site 266265013101 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265013102 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266265013103 putative DNA binding site [nucleotide binding]; other site 266265013104 putative Zn2+ binding site [ion binding]; other site 266265013105 AsnC family; Region: AsnC_trans_reg; pfam01037 266265013106 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 266265013107 cofactor binding site; other site 266265013108 metal binding site [ion binding]; metal-binding site 266265013109 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 266265013110 aromatic arch; other site 266265013111 DCoH dimer interaction site [polypeptide binding]; other site 266265013112 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 266265013113 DCoH tetramer interaction site [polypeptide binding]; other site 266265013114 substrate binding site [chemical binding]; other site 266265013115 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 266265013116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265013117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265013118 active site 266265013119 phosphorylation site [posttranslational modification] 266265013120 intermolecular recognition site; other site 266265013121 dimerization interface [polypeptide binding]; other site 266265013122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265013123 DNA binding site [nucleotide binding] 266265013124 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266265013125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265013126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266265013127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265013128 dimer interface [polypeptide binding]; other site 266265013129 phosphorylation site [posttranslational modification] 266265013130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265013131 ATP binding site [chemical binding]; other site 266265013132 Mg2+ binding site [ion binding]; other site 266265013133 G-X-G motif; other site 266265013134 Proteins containing SET domain [General function prediction only]; Region: COG2940 266265013135 SET domain; Region: SET; pfam00856 266265013136 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266265013137 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266265013138 active site 266265013139 FMN binding site [chemical binding]; other site 266265013140 substrate binding site [chemical binding]; other site 266265013141 homotetramer interface [polypeptide binding]; other site 266265013142 catalytic residue [active] 266265013143 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 266265013144 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 266265013145 catalytic triad [active] 266265013146 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265013147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265013148 putative DNA binding site [nucleotide binding]; other site 266265013149 putative Zn2+ binding site [ion binding]; other site 266265013150 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 266265013151 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 266265013152 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266265013153 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 266265013154 Uncharacterized conserved protein [Function unknown]; Region: COG4121 266265013155 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266265013156 IHF dimer interface [polypeptide binding]; other site 266265013157 IHF - DNA interface [nucleotide binding]; other site 266265013158 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 266265013159 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 266265013160 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 266265013161 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266265013162 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265013163 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265013164 catalytic residue [active] 266265013165 type II secretion system protein D; Region: type_II_gspD; TIGR02517 266265013166 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266265013167 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266265013168 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 266265013169 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 266265013170 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266265013171 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 266265013172 type II secretion system protein E; Region: type_II_gspE; TIGR02533 266265013173 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 266265013174 Walker A motif; other site 266265013175 ATP binding site [chemical binding]; other site 266265013176 Walker B motif; other site 266265013177 type II secretion system protein F; Region: GspF; TIGR02120 266265013178 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266265013179 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266265013180 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 266265013181 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 266265013182 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 266265013183 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 266265013184 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 266265013185 Type II transport protein GspH; Region: GspH; pfam12019 266265013186 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 266265013187 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 266265013188 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 266265013189 GspL periplasmic domain; Region: GspL_C; pfam12693 266265013190 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 266265013191 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 266265013192 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265013193 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265013194 MarR family; Region: MarR_2; cl17246 266265013195 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265013196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265013197 putative substrate translocation pore; other site 266265013198 glutamate--cysteine ligase; Provisional; Region: PRK02107 266265013199 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 266265013200 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 266265013201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265013202 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 266265013203 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266265013204 DNA binding site [nucleotide binding] 266265013205 active site 266265013206 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 266265013207 dimer interface [polypeptide binding]; other site 266265013208 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265013209 metal binding site [ion binding]; metal-binding site 266265013210 YaeQ protein; Region: YaeQ; pfam07152 266265013211 dihydroxy-acid dehydratase; Validated; Region: PRK06131 266265013212 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266265013213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265013214 Coenzyme A binding pocket [chemical binding]; other site 266265013215 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 266265013216 HIT family signature motif; other site 266265013217 catalytic residue [active] 266265013218 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265013219 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266265013220 conserved cys residue [active] 266265013221 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 266265013222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265013223 NAD(P) binding site [chemical binding]; other site 266265013224 active site 266265013225 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265013226 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 266265013227 putative DNA binding site [nucleotide binding]; other site 266265013228 putative Zn2+ binding site [ion binding]; other site 266265013229 AsnC family; Region: AsnC_trans_reg; pfam01037 266265013230 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 266265013231 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266265013232 dimer interface [polypeptide binding]; other site 266265013233 TPP-binding site [chemical binding]; other site 266265013234 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 266265013235 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 266265013236 integrase; Provisional; Region: PRK09692 266265013237 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266265013238 active site 266265013239 Int/Topo IB signature motif; other site 266265013240 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 266265013241 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 266265013242 trmE is a tRNA modification GTPase; Region: trmE; cd04164 266265013243 G1 box; other site 266265013244 GTP/Mg2+ binding site [chemical binding]; other site 266265013245 Switch I region; other site 266265013246 G2 box; other site 266265013247 Switch II region; other site 266265013248 G3 box; other site 266265013249 G4 box; other site 266265013250 G5 box; other site 266265013251 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 266265013252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266265013253 non-specific DNA binding site [nucleotide binding]; other site 266265013254 salt bridge; other site 266265013255 sequence-specific DNA binding site [nucleotide binding]; other site 266265013256 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 266265013257 non-specific DNA binding site [nucleotide binding]; other site 266265013258 salt bridge; other site 266265013259 sequence-specific DNA binding site [nucleotide binding]; other site 266265013260 membrane protein insertase; Provisional; Region: PRK01318 266265013261 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 266265013262 hypothetical protein; Validated; Region: PRK00041 266265013263 Ribonuclease P; Region: Ribonuclease_P; cl00457 266265013264 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 266265013265 ParA-like protein; Provisional; Region: PHA02518 266265013266 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265013267 P-loop; other site 266265013268 Magnesium ion binding site [ion binding]; other site 266265013269 ParB-like nuclease domain; Region: ParB; smart00470 266265013270 Initiator Replication protein; Region: Rep_3; pfam01051 266265013271 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 266265013272 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266265013273 active site 266265013274 catalytic residues [active] 266265013275 Int/Topo IB signature motif; other site 266265013276 DNA binding site [nucleotide binding] 266265013277 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 266265013278 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265013279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265013280 non-specific DNA binding site [nucleotide binding]; other site 266265013281 salt bridge; other site 266265013282 sequence-specific DNA binding site [nucleotide binding]; other site 266265013283 Cupin domain; Region: Cupin_2; pfam07883 266265013284 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 266265013285 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 266265013286 substrate-cofactor binding pocket; other site 266265013287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265013288 catalytic residue [active] 266265013289 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 266265013290 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266265013291 NAD(P) binding site [chemical binding]; other site 266265013292 YceI-like domain; Region: YceI; smart00867 266265013293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265013294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265013295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 266265013296 SnoaL-like domain; Region: SnoaL_2; pfam12680 266265013297 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265013298 MarR family; Region: MarR_2; pfam12802 266265013299 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 266265013300 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 266265013301 active site 266265013302 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266265013303 PLD-like domain; Region: PLDc_2; pfam13091 266265013304 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 266265013305 putative active site [active] 266265013306 catalytic site [active] 266265013307 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 266265013308 putative active site [active] 266265013309 catalytic site [active] 266265013310 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266265013311 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266265013312 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265013313 dimerization interface [polypeptide binding]; other site 266265013314 PAS domain; Region: PAS_9; pfam13426 266265013315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265013316 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 266265013317 putative binding surface; other site 266265013318 active site 266265013319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265013320 ATP binding site [chemical binding]; other site 266265013321 Mg2+ binding site [ion binding]; other site 266265013322 G-X-G motif; other site 266265013323 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 266265013324 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 266265013325 Response regulator receiver domain; Region: Response_reg; pfam00072 266265013326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265013327 active site 266265013328 phosphorylation site [posttranslational modification] 266265013329 intermolecular recognition site; other site 266265013330 dimerization interface [polypeptide binding]; other site 266265013331 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266265013332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265013333 active site 266265013334 phosphorylation site [posttranslational modification] 266265013335 intermolecular recognition site; other site 266265013336 dimerization interface [polypeptide binding]; other site 266265013337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265013338 DNA binding site [nucleotide binding] 266265013339 short chain dehydrogenase; Provisional; Region: PRK07023 266265013340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265013341 NAD(P) binding site [chemical binding]; other site 266265013342 active site 266265013343 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265013344 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266265013345 conserved cys residue [active] 266265013346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265013347 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 266265013348 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265013349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265013350 DNA-binding site [nucleotide binding]; DNA binding site 266265013351 FCD domain; Region: FCD; pfam07729 266265013352 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 266265013353 homodimer interface [polypeptide binding]; other site 266265013354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265013355 catalytic residue [active] 266265013356 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 266265013357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265013358 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266265013359 putative dimerization interface [polypeptide binding]; other site 266265013360 benzoate transport; Region: 2A0115; TIGR00895 266265013361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265013362 putative substrate translocation pore; other site 266265013363 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265013364 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265013365 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 266265013366 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265013367 substrate binding site [chemical binding]; other site 266265013368 oxyanion hole (OAH) forming residues; other site 266265013369 trimer interface [polypeptide binding]; other site 266265013370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265013371 dimer interface [polypeptide binding]; other site 266265013372 conserved gate region; other site 266265013373 putative PBP binding loops; other site 266265013374 ABC-ATPase subunit interface; other site 266265013375 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 266265013376 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 266265013377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265013378 dimer interface [polypeptide binding]; other site 266265013379 conserved gate region; other site 266265013380 putative PBP binding loops; other site 266265013381 ABC-ATPase subunit interface; other site 266265013382 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 266265013383 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 266265013384 Walker A/P-loop; other site 266265013385 ATP binding site [chemical binding]; other site 266265013386 Q-loop/lid; other site 266265013387 ABC transporter signature motif; other site 266265013388 Walker B; other site 266265013389 D-loop; other site 266265013390 H-loop/switch region; other site 266265013391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 266265013392 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265013393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 266265013394 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 266265013395 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265013396 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265013397 ligand binding site [chemical binding]; other site 266265013398 flexible hinge region; other site 266265013399 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 266265013400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265013401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265013402 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266265013403 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266265013404 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266265013405 active site residue [active] 266265013406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265013407 PAS domain; Region: PAS_9; pfam13426 266265013408 putative active site [active] 266265013409 heme pocket [chemical binding]; other site 266265013410 HAMP domain; Region: HAMP; pfam00672 266265013411 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265013412 dimer interface [polypeptide binding]; other site 266265013413 putative CheW interface [polypeptide binding]; other site 266265013414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265013415 dimer interface [polypeptide binding]; other site 266265013416 phosphorylation site [posttranslational modification] 266265013417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265013418 ATP binding site [chemical binding]; other site 266265013419 Mg2+ binding site [ion binding]; other site 266265013420 G-X-G motif; other site 266265013421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265013422 active site 266265013423 phosphorylation site [posttranslational modification] 266265013424 intermolecular recognition site; other site 266265013425 dimerization interface [polypeptide binding]; other site 266265013426 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266265013427 homotrimer interaction site [polypeptide binding]; other site 266265013428 putative active site [active] 266265013429 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 266265013430 PAS fold; Region: PAS_4; pfam08448 266265013431 PAS domain; Region: PAS; smart00091 266265013432 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 266265013433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265013434 Walker A motif; other site 266265013435 ATP binding site [chemical binding]; other site 266265013436 Walker B motif; other site 266265013437 arginine finger; other site 266265013438 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265013439 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266265013440 Beta-lactamase; Region: Beta-lactamase; pfam00144 266265013441 H-NS histone family; Region: Histone_HNS; pfam00816 266265013442 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266265013443 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266265013444 putative chaperone protein EcpD; Provisional; Region: PRK09926 266265013445 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266265013446 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266265013447 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266265013448 PapC N-terminal domain; Region: PapC_N; pfam13954 266265013449 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266265013450 PapC C-terminal domain; Region: PapC_C; pfam13953 266265013451 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266265013452 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 266265013453 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 266265013454 G1 box; other site 266265013455 putative GEF interaction site [polypeptide binding]; other site 266265013456 GTP/Mg2+ binding site [chemical binding]; other site 266265013457 Switch I region; other site 266265013458 G2 box; other site 266265013459 G3 box; other site 266265013460 Switch II region; other site 266265013461 G4 box; other site 266265013462 G5 box; other site 266265013463 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 266265013464 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 266265013465 CoA binding domain; Region: CoA_binding_2; pfam13380 266265013466 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266265013467 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266265013468 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266265013469 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266265013470 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265013471 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265013472 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265013473 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266265013474 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266265013475 ligand binding site [chemical binding]; other site 266265013476 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265013477 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265013478 Walker A/P-loop; other site 266265013479 ATP binding site [chemical binding]; other site 266265013480 Q-loop/lid; other site 266265013481 ABC transporter signature motif; other site 266265013482 Walker B; other site 266265013483 D-loop; other site 266265013484 H-loop/switch region; other site 266265013485 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265013486 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265013487 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265013488 TM-ABC transporter signature motif; other site 266265013489 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266265013490 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266265013491 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265013492 active site 266265013493 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265013494 catalytic tetrad [active] 266265013495 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266265013496 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265013497 active site 266265013498 short chain dehydrogenase; Provisional; Region: PRK06138 266265013499 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 266265013500 NAD binding site [chemical binding]; other site 266265013501 homotetramer interface [polypeptide binding]; other site 266265013502 homodimer interface [polypeptide binding]; other site 266265013503 active site 266265013504 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265013505 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265013506 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 266265013507 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265013508 catalytic residue [active] 266265013509 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265013510 dimerization interface [polypeptide binding]; other site 266265013511 putative DNA binding site [nucleotide binding]; other site 266265013512 putative Zn2+ binding site [ion binding]; other site 266265013513 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266265013514 CoenzymeA binding site [chemical binding]; other site 266265013515 subunit interaction site [polypeptide binding]; other site 266265013516 PHB binding site; other site 266265013517 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 266265013518 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 266265013519 dimer interface [polypeptide binding]; other site 266265013520 ligand binding site [chemical binding]; other site 266265013521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265013522 dimerization interface [polypeptide binding]; other site 266265013523 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265013524 dimer interface [polypeptide binding]; other site 266265013525 putative CheW interface [polypeptide binding]; other site 266265013526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266265013527 DNA-binding site [nucleotide binding]; DNA binding site 266265013528 RNA-binding motif; other site 266265013529 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 266265013530 putative active cleft [active] 266265013531 MgtC family; Region: MgtC; pfam02308 266265013532 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 266265013533 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265013534 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265013535 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 266265013536 Cupin domain; Region: Cupin_2; cl17218 266265013537 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 266265013538 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 266265013539 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 266265013540 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265013541 putative C-terminal domain interface [polypeptide binding]; other site 266265013542 putative GSH binding site (G-site) [chemical binding]; other site 266265013543 putative dimer interface [polypeptide binding]; other site 266265013544 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 266265013545 putative N-terminal domain interface [polypeptide binding]; other site 266265013546 putative dimer interface [polypeptide binding]; other site 266265013547 putative substrate binding pocket (H-site) [chemical binding]; other site 266265013548 Cache domain; Region: Cache_1; pfam02743 266265013549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265013550 dimerization interface [polypeptide binding]; other site 266265013551 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265013552 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265013553 dimer interface [polypeptide binding]; other site 266265013554 putative CheW interface [polypeptide binding]; other site 266265013555 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 266265013556 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266265013557 metal-binding site [ion binding] 266265013558 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266265013559 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 266265013560 Uncharacterized conserved protein [Function unknown]; Region: COG5361 266265013561 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 266265013562 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 266265013563 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266265013564 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266265013565 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266265013566 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 266265013567 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265013568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265013569 DNA-binding site [nucleotide binding]; DNA binding site 266265013570 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265013571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265013572 homodimer interface [polypeptide binding]; other site 266265013573 catalytic residue [active] 266265013574 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265013575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265013576 Walker A/P-loop; other site 266265013577 ATP binding site [chemical binding]; other site 266265013578 Q-loop/lid; other site 266265013579 ABC transporter signature motif; other site 266265013580 Walker B; other site 266265013581 D-loop; other site 266265013582 H-loop/switch region; other site 266265013583 TOBE domain; Region: TOBE_2; pfam08402 266265013584 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266265013585 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265013586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265013587 dimer interface [polypeptide binding]; other site 266265013588 conserved gate region; other site 266265013589 putative PBP binding loops; other site 266265013590 ABC-ATPase subunit interface; other site 266265013591 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265013592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265013593 dimer interface [polypeptide binding]; other site 266265013594 conserved gate region; other site 266265013595 putative PBP binding loops; other site 266265013596 ABC-ATPase subunit interface; other site 266265013597 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265013598 ligand binding site [chemical binding]; other site 266265013599 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265013600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265013601 active site 266265013602 phosphorylation site [posttranslational modification] 266265013603 intermolecular recognition site; other site 266265013604 dimerization interface [polypeptide binding]; other site 266265013605 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265013606 DNA binding residues [nucleotide binding] 266265013607 dimerization interface [polypeptide binding]; other site 266265013608 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 266265013609 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266265013610 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265013611 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265013612 catalytic residue [active] 266265013613 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 266265013614 TadE-like protein; Region: TadE; pfam07811 266265013615 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 266265013616 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 266265013617 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266265013618 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 266265013619 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 266265013620 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266265013621 phosphopeptide binding site; other site 266265013622 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 266265013623 Type II/IV secretion system protein; Region: T2SE; pfam00437 266265013624 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266265013625 ATP binding site [chemical binding]; other site 266265013626 Walker A motif; other site 266265013627 hexamer interface [polypeptide binding]; other site 266265013628 Walker B motif; other site 266265013629 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 266265013630 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 266265013631 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 266265013632 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266265013633 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266265013634 DNA binding residues [nucleotide binding] 266265013635 dimer interface [polypeptide binding]; other site 266265013636 putative metal binding site [ion binding]; other site 266265013637 Heavy-metal-associated domain; Region: HMA; pfam00403 266265013638 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265013639 lipoprotein signal peptidase; Provisional; Region: PRK14776 266265013640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266265013641 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266265013642 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266265013643 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266265013644 trimer interface [polypeptide binding]; other site 266265013645 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 266265013646 YadA-like C-terminal region; Region: YadA; pfam03895 266265013647 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265013648 ligand binding site [chemical binding]; other site 266265013649 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265013650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265013651 active site 266265013652 phosphorylation site [posttranslational modification] 266265013653 intermolecular recognition site; other site 266265013654 dimerization interface [polypeptide binding]; other site 266265013655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265013656 DNA binding residues [nucleotide binding] 266265013657 dimerization interface [polypeptide binding]; other site 266265013658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265013659 ATP binding site [chemical binding]; other site 266265013660 Mg2+ binding site [ion binding]; other site 266265013661 G-X-G motif; other site 266265013662 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 266265013663 aconitate hydratase; Provisional; Region: acnA; PRK12881 266265013664 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266265013665 substrate binding site [chemical binding]; other site 266265013666 ligand binding site [chemical binding]; other site 266265013667 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 266265013668 substrate binding site [chemical binding]; other site 266265013669 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 266265013670 2-methylcitrate dehydratase; Region: prpD; TIGR02330 266265013671 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266265013672 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 266265013673 dimer interface [polypeptide binding]; other site 266265013674 active site 266265013675 citrylCoA binding site [chemical binding]; other site 266265013676 oxalacetate/citrate binding site [chemical binding]; other site 266265013677 coenzyme A binding site [chemical binding]; other site 266265013678 catalytic triad [active] 266265013679 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266265013680 malate dehydrogenase; Provisional; Region: PRK05442 266265013681 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 266265013682 NAD(P) binding site [chemical binding]; other site 266265013683 dimer interface [polypeptide binding]; other site 266265013684 malate binding site [chemical binding]; other site 266265013685 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266265013686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265013687 DNA-binding site [nucleotide binding]; DNA binding site 266265013688 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 266265013689 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 266265013690 Iron-sulfur protein interface; other site 266265013691 proximal quinone binding site [chemical binding]; other site 266265013692 SdhD (CybS) interface [polypeptide binding]; other site 266265013693 proximal heme binding site [chemical binding]; other site 266265013694 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 266265013695 SdhC subunit interface [polypeptide binding]; other site 266265013696 proximal heme binding site [chemical binding]; other site 266265013697 cardiolipin binding site; other site 266265013698 Iron-sulfur protein interface; other site 266265013699 proximal quinone binding site [chemical binding]; other site 266265013700 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 266265013701 L-aspartate oxidase; Provisional; Region: PRK06175 266265013702 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 266265013703 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 266265013704 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 266265013705 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 266265013706 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 266265013707 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266265013708 dimer interface [polypeptide binding]; other site 266265013709 active site 266265013710 citrylCoA binding site [chemical binding]; other site 266265013711 NADH binding [chemical binding]; other site 266265013712 cationic pore residues; other site 266265013713 oxalacetate/citrate binding site [chemical binding]; other site 266265013714 coenzyme A binding site [chemical binding]; other site 266265013715 catalytic triad [active] 266265013716 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266265013717 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266265013718 substrate binding site [chemical binding]; other site 266265013719 ligand binding site [chemical binding]; other site 266265013720 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266265013721 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266265013722 substrate binding site [chemical binding]; other site 266265013723 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 266265013724 tartrate dehydrogenase; Region: TTC; TIGR02089 266265013725 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 266265013726 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266265013727 FimV N-terminal domain; Region: FimV_core; TIGR03505 266265013728 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 266265013729 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 266265013730 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 266265013731 dimerization interface 3.5A [polypeptide binding]; other site 266265013732 active site 266265013733 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 266265013734 active site 266265013735 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 266265013736 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 266265013737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265013738 catalytic residue [active] 266265013739 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 266265013740 DNA methylase; Region: N6_N4_Mtase; pfam01555 266265013741 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 266265013742 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 266265013743 substrate binding site [chemical binding]; other site 266265013744 active site 266265013745 catalytic residues [active] 266265013746 heterodimer interface [polypeptide binding]; other site 266265013747 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 266265013748 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 266265013749 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266265013750 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 266265013751 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 266265013752 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 266265013753 Sporulation related domain; Region: SPOR; pfam05036 266265013754 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 266265013755 Colicin V production protein; Region: Colicin_V; pfam02674 266265013756 amidophosphoribosyltransferase; Provisional; Region: PRK09246 266265013757 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 266265013758 active site 266265013759 tetramer interface [polypeptide binding]; other site 266265013760 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265013761 active site 266265013762 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 266265013763 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 266265013764 homodimer interface [polypeptide binding]; other site 266265013765 substrate-cofactor binding pocket; other site 266265013766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265013767 catalytic residue [active] 266265013768 Cupin domain; Region: Cupin_2; pfam07883 266265013769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265013770 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265013771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265013772 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 266265013773 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266265013774 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265013775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265013776 dimer interface [polypeptide binding]; other site 266265013777 phosphorylation site [posttranslational modification] 266265013778 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 266265013779 Domain of unknown function DUF21; Region: DUF21; pfam01595 266265013780 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 266265013781 Transporter associated domain; Region: CorC_HlyC; smart01091 266265013782 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266265013783 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 266265013784 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 266265013785 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 266265013786 active site 266265013787 catalytic site [active] 266265013788 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 266265013789 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 266265013790 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 266265013791 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 266265013792 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 266265013793 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 266265013794 catalytic site [active] 266265013795 active site 266265013796 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 266265013797 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 266265013798 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 266265013799 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 266265013800 active site 266265013801 catalytic site [active] 266265013802 glycogen branching enzyme; Provisional; Region: PRK05402 266265013803 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 266265013804 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 266265013805 active site 266265013806 catalytic site [active] 266265013807 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 266265013808 trehalose synthase; Region: treS_nterm; TIGR02456 266265013809 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 266265013810 active site 266265013811 catalytic site [active] 266265013812 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 266265013813 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 266265013814 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 266265013815 active site 266265013816 catalytic site [active] 266265013817 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 266265013818 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 266265013819 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 266265013820 active site 266265013821 homodimer interface [polypeptide binding]; other site 266265013822 catalytic site [active] 266265013823 acceptor binding site [chemical binding]; other site 266265013824 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 266265013825 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266265013826 active site 266265013827 metal binding site [ion binding]; metal-binding site 266265013828 RES domain; Region: RES; smart00953 266265013829 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 266265013830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265013831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265013832 dimerization interface [polypeptide binding]; other site 266265013833 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266265013834 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266265013835 active site 1 [active] 266265013836 dimer interface [polypeptide binding]; other site 266265013837 hexamer interface [polypeptide binding]; other site 266265013838 active site 2 [active] 266265013839 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265013840 classical (c) SDRs; Region: SDR_c; cd05233 266265013841 NAD(P) binding site [chemical binding]; other site 266265013842 active site 266265013843 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 266265013844 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 266265013845 molybdenum-pterin binding domain; Region: Mop; TIGR00638 266265013846 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 266265013847 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266265013848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265013849 Walker A/P-loop; other site 266265013850 ATP binding site [chemical binding]; other site 266265013851 Q-loop/lid; other site 266265013852 ABC transporter signature motif; other site 266265013853 Walker B; other site 266265013854 D-loop; other site 266265013855 H-loop/switch region; other site 266265013856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265013857 dimer interface [polypeptide binding]; other site 266265013858 conserved gate region; other site 266265013859 putative PBP binding loops; other site 266265013860 ABC-ATPase subunit interface; other site 266265013861 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266265013862 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266265013863 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 266265013864 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 266265013865 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265013866 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 266265013867 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 266265013868 DNA photolyase; Region: DNA_photolyase; pfam00875 266265013869 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 266265013870 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265013871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265013872 putative DNA binding site [nucleotide binding]; other site 266265013873 putative Zn2+ binding site [ion binding]; other site 266265013874 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 266265013875 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 266265013876 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 266265013877 putative active site [active] 266265013878 putative substrate binding site [chemical binding]; other site 266265013879 ATP binding site [chemical binding]; other site 266265013880 AMP nucleosidase; Provisional; Region: PRK08292 266265013881 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 266265013882 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 266265013883 Chromate transporter; Region: Chromate_transp; pfam02417 266265013884 Chromate transporter; Region: Chromate_transp; pfam02417 266265013885 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 266265013886 DNA polymerase I; Provisional; Region: PRK05755 266265013887 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 266265013888 active site 266265013889 metal binding site 1 [ion binding]; metal-binding site 266265013890 putative 5' ssDNA interaction site; other site 266265013891 metal binding site 3; metal-binding site 266265013892 metal binding site 2 [ion binding]; metal-binding site 266265013893 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 266265013894 putative DNA binding site [nucleotide binding]; other site 266265013895 putative metal binding site [ion binding]; other site 266265013896 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 266265013897 active site 266265013898 catalytic site [active] 266265013899 substrate binding site [chemical binding]; other site 266265013900 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 266265013901 active site 266265013902 DNA binding site [nucleotide binding] 266265013903 catalytic site [active] 266265013904 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266265013905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265013906 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266265013907 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266265013908 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 266265013909 active site residue [active] 266265013910 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266265013911 active site residue [active] 266265013912 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265013913 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265013914 [2Fe-2S] cluster binding site [ion binding]; other site 266265013915 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 266265013916 alpha subunit interface [polypeptide binding]; other site 266265013917 active site 266265013918 substrate binding site [chemical binding]; other site 266265013919 Fe binding site [ion binding]; other site 266265013920 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 266265013921 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 266265013922 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 266265013923 substrate binding pocket [chemical binding]; other site 266265013924 chain length determination region; other site 266265013925 substrate-Mg2+ binding site; other site 266265013926 catalytic residues [active] 266265013927 aspartate-rich region 1; other site 266265013928 active site lid residues [active] 266265013929 aspartate-rich region 2; other site 266265013930 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 266265013931 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 266265013932 TPP-binding site; other site 266265013933 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266265013934 PYR/PP interface [polypeptide binding]; other site 266265013935 dimer interface [polypeptide binding]; other site 266265013936 TPP binding site [chemical binding]; other site 266265013937 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266265013938 putative GTP cyclohydrolase; Provisional; Region: PRK13674 266265013939 UGMP family protein; Validated; Region: PRK09604 266265013940 HI0933-like protein; Region: HI0933_like; pfam03486 266265013941 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 266265013942 Yqey-like protein; Region: YqeY; pfam09424 266265013943 DNA primase; Validated; Region: dnaG; PRK05667 266265013944 CHC2 zinc finger; Region: zf-CHC2; pfam01807 266265013945 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 266265013946 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 266265013947 active site 266265013948 metal binding site [ion binding]; metal-binding site 266265013949 interdomain interaction site; other site 266265013950 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 266265013951 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 266265013952 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266265013953 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266265013954 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266265013955 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266265013956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265013957 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266265013958 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265013959 DNA binding residues [nucleotide binding] 266265013960 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265013961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265013962 DNA-binding site [nucleotide binding]; DNA binding site 266265013963 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266265013964 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265013965 catalytic residue [active] 266265013966 OsmC-like protein; Region: OsmC; pfam02566 266265013967 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265013968 active site 266265013969 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265013970 non-prolyl cis peptide bond; other site 266265013971 benzoate transport; Region: 2A0115; TIGR00895 266265013972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265013973 putative substrate translocation pore; other site 266265013974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265013975 dimerization interface [polypeptide binding]; other site 266265013976 putative DNA binding site [nucleotide binding]; other site 266265013977 putative Zn2+ binding site [ion binding]; other site 266265013978 peroxiredoxin; Provisional; Region: PRK13189 266265013979 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266265013980 dimer interface [polypeptide binding]; other site 266265013981 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266265013982 catalytic triad [active] 266265013983 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266265013984 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266265013985 active site 266265013986 inhibitor site; inhibition site 266265013987 dimer interface [polypeptide binding]; other site 266265013988 catalytic residue [active] 266265013989 Domain of unknown function (DUF336); Region: DUF336; cl01249 266265013990 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266265013991 active site 266265013992 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266265013993 dimer interface [polypeptide binding]; other site 266265013994 non-prolyl cis peptide bond; other site 266265013995 insertion regions; other site 266265013996 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265013997 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265013998 active site 266265013999 non-prolyl cis peptide bond; other site 266265014000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265014001 substrate binding site [chemical binding]; other site 266265014002 oxyanion hole (OAH) forming residues; other site 266265014003 trimer interface [polypeptide binding]; other site 266265014004 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265014005 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 266265014006 ligand binding site [chemical binding]; other site 266265014007 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266265014008 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265014009 TM-ABC transporter signature motif; other site 266265014010 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265014011 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265014012 TM-ABC transporter signature motif; other site 266265014013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265014014 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 266265014015 Walker A/P-loop; other site 266265014016 ATP binding site [chemical binding]; other site 266265014017 Q-loop/lid; other site 266265014018 ABC transporter signature motif; other site 266265014019 Walker B; other site 266265014020 D-loop; other site 266265014021 H-loop/switch region; other site 266265014022 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265014023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265014024 Walker A/P-loop; other site 266265014025 ATP binding site [chemical binding]; other site 266265014026 Q-loop/lid; other site 266265014027 ABC transporter signature motif; other site 266265014028 Walker B; other site 266265014029 D-loop; other site 266265014030 H-loop/switch region; other site 266265014031 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265014032 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265014033 trimer interface [polypeptide binding]; other site 266265014034 eyelet of channel; other site 266265014035 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 266265014036 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 266265014037 dimer interface [polypeptide binding]; other site 266265014038 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266265014039 catalytic triad [active] 266265014040 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265014041 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266265014042 conserved cys residue [active] 266265014043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265014044 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 266265014045 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 266265014046 WYL domain; Region: WYL; pfam13280 266265014047 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 266265014048 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265014049 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266265014050 conserved cys residue [active] 266265014051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265014052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265014053 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265014054 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265014055 eyelet of channel; other site 266265014056 trimer interface [polypeptide binding]; other site 266265014057 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266265014058 Cache domain; Region: Cache_2; pfam08269 266265014059 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265014060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265014061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265014062 dimer interface [polypeptide binding]; other site 266265014063 putative CheW interface [polypeptide binding]; other site 266265014064 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265014065 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265014066 ligand binding site [chemical binding]; other site 266265014067 flexible hinge region; other site 266265014068 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266265014069 acyl-CoA synthetase; Validated; Region: PRK08162 266265014070 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 266265014071 acyl-activating enzyme (AAE) consensus motif; other site 266265014072 putative active site [active] 266265014073 AMP binding site [chemical binding]; other site 266265014074 putative CoA binding site [chemical binding]; other site 266265014075 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 266265014076 DNA-binding site [nucleotide binding]; DNA binding site 266265014077 RNA-binding motif; other site 266265014078 LysE type translocator; Region: LysE; cl00565 266265014079 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266265014080 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 266265014081 heterodimer interface [polypeptide binding]; other site 266265014082 active site 266265014083 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 266265014084 heterodimer interface [polypeptide binding]; other site 266265014085 multimer interface [polypeptide binding]; other site 266265014086 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 266265014087 active site 266265014088 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266265014089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014090 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 266265014091 putative dimerization interface [polypeptide binding]; other site 266265014092 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 266265014093 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 266265014094 dimer interface [polypeptide binding]; other site 266265014095 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266265014096 active site 266265014097 Fe binding site [ion binding]; other site 266265014098 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265014099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014100 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265014101 dimerization interface [polypeptide binding]; other site 266265014102 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 266265014103 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265014104 FAD binding domain; Region: FAD_binding_4; pfam01565 266265014105 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266265014106 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266265014107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265014108 non-specific DNA binding site [nucleotide binding]; other site 266265014109 salt bridge; other site 266265014110 sequence-specific DNA binding site [nucleotide binding]; other site 266265014111 Cupin domain; Region: Cupin_2; pfam07883 266265014112 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 266265014113 PBP superfamily domain; Region: PBP_like_2; cl17296 266265014114 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 266265014115 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 266265014116 Cl binding site [ion binding]; other site 266265014117 oligomer interface [polypeptide binding]; other site 266265014118 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 266265014119 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265014120 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265014121 PBP superfamily domain; Region: PBP_like_2; cl17296 266265014122 PAS domain S-box; Region: sensory_box; TIGR00229 266265014123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265014124 putative active site [active] 266265014125 heme pocket [chemical binding]; other site 266265014126 formyl-coenzyme A transferase; Provisional; Region: PRK05398 266265014127 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265014128 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 266265014129 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265014130 PYR/PP interface [polypeptide binding]; other site 266265014131 dimer interface [polypeptide binding]; other site 266265014132 TPP binding site [chemical binding]; other site 266265014133 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265014134 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 266265014135 TPP-binding site; other site 266265014136 dimer interface [polypeptide binding]; other site 266265014137 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 266265014138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265014139 putative substrate translocation pore; other site 266265014140 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265014141 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266265014142 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265014143 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265014144 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265014145 iron-sulfur cluster [ion binding]; other site 266265014146 [2Fe-2S] cluster binding site [ion binding]; other site 266265014147 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 266265014148 putative alpha subunit interface [polypeptide binding]; other site 266265014149 putative active site [active] 266265014150 putative substrate binding site [chemical binding]; other site 266265014151 Fe binding site [ion binding]; other site 266265014152 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265014153 inter-subunit interface; other site 266265014154 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 266265014155 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 266265014156 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 266265014157 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265014158 catalytic loop [active] 266265014159 iron binding site [ion binding]; other site 266265014160 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 266265014161 FAD binding pocket [chemical binding]; other site 266265014162 FAD binding motif [chemical binding]; other site 266265014163 phosphate binding motif [ion binding]; other site 266265014164 beta-alpha-beta structure motif; other site 266265014165 NAD binding pocket [chemical binding]; other site 266265014166 benzoate transport; Region: 2A0115; TIGR00895 266265014167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265014168 putative substrate translocation pore; other site 266265014169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265014170 putative substrate translocation pore; other site 266265014171 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265014172 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265014173 trimer interface [polypeptide binding]; other site 266265014174 eyelet of channel; other site 266265014175 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 266265014176 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266265014177 Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851 266265014178 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 266265014179 active site 266265014180 catalytic triad [active] 266265014181 oxyanion hole [active] 266265014182 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266265014183 AAA ATPase domain; Region: AAA_16; pfam13191 266265014184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265014185 DNA binding residues [nucleotide binding] 266265014186 dimerization interface [polypeptide binding]; other site 266265014187 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265014188 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265014189 active site 266265014190 lipid-transfer protein; Provisional; Region: PRK08256 266265014191 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265014192 active site 266265014193 short chain dehydrogenase; Provisional; Region: PRK07791 266265014194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265014195 NAD(P) binding site [chemical binding]; other site 266265014196 active site 266265014197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265014198 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 266265014199 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266265014200 acyl-activating enzyme (AAE) consensus motif; other site 266265014201 acyl-activating enzyme (AAE) consensus motif; other site 266265014202 putative AMP binding site [chemical binding]; other site 266265014203 putative active site [active] 266265014204 putative CoA binding site [chemical binding]; other site 266265014205 CoA binding site [chemical binding]; other site 266265014206 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265014207 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265014208 active site 266265014209 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266265014210 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265014211 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265014212 enoyl-CoA hydratase; Provisional; Region: PRK09245 266265014213 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265014214 substrate binding site [chemical binding]; other site 266265014215 oxyanion hole (OAH) forming residues; other site 266265014216 trimer interface [polypeptide binding]; other site 266265014217 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 266265014218 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 266265014219 FMN binding site [chemical binding]; other site 266265014220 substrate binding site [chemical binding]; other site 266265014221 putative catalytic residue [active] 266265014222 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265014223 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265014224 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266265014225 Ligand binding site [chemical binding]; other site 266265014226 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266265014227 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266265014228 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266265014229 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266265014230 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265014231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265014232 NAD(P) binding site [chemical binding]; other site 266265014233 active site 266265014234 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 266265014235 active site 266265014236 catalytic site [active] 266265014237 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266265014238 active site 266265014239 catalytic site [active] 266265014240 lipid-transfer protein; Provisional; Region: PRK08256 266265014241 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265014242 active site 266265014243 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265014244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265014245 active site 266265014246 feruloyl-CoA synthase; Reviewed; Region: PRK08180 266265014247 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 266265014248 acyl-activating enzyme (AAE) consensus motif; other site 266265014249 putative AMP binding site [chemical binding]; other site 266265014250 putative active site [active] 266265014251 putative CoA binding site [chemical binding]; other site 266265014252 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 266265014253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266265014254 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265014255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265014256 DNA binding residues [nucleotide binding] 266265014257 dimerization interface [polypeptide binding]; other site 266265014258 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266265014259 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265014260 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265014261 trimer interface [polypeptide binding]; other site 266265014262 eyelet of channel; other site 266265014263 BON domain; Region: BON; pfam04972 266265014264 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266265014265 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265014266 NAD binding site [chemical binding]; other site 266265014267 catalytic residues [active] 266265014268 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266265014269 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265014270 choline dehydrogenase; Validated; Region: PRK02106 266265014271 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265014272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265014273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265014274 putative substrate translocation pore; other site 266265014275 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266265014276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265014277 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 266265014278 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266265014279 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 266265014280 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266265014281 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265014282 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266265014283 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266265014284 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266265014285 homotrimer interaction site [polypeptide binding]; other site 266265014286 putative active site [active] 266265014287 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265014288 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265014289 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266265014290 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266265014291 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265014292 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265014293 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265014294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265014295 dimer interface [polypeptide binding]; other site 266265014296 conserved gate region; other site 266265014297 putative PBP binding loops; other site 266265014298 ABC-ATPase subunit interface; other site 266265014299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265014300 putative PBP binding loops; other site 266265014301 dimer interface [polypeptide binding]; other site 266265014302 ABC-ATPase subunit interface; other site 266265014303 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265014304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265014305 Walker A/P-loop; other site 266265014306 ATP binding site [chemical binding]; other site 266265014307 Q-loop/lid; other site 266265014308 ABC transporter signature motif; other site 266265014309 Walker B; other site 266265014310 D-loop; other site 266265014311 H-loop/switch region; other site 266265014312 TOBE domain; Region: TOBE_2; pfam08402 266265014313 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266265014314 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265014315 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266265014316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014317 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265014318 dimerization interface [polypeptide binding]; other site 266265014319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265014321 dimerization interface [polypeptide binding]; other site 266265014322 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266265014323 PYR/PP interface [polypeptide binding]; other site 266265014324 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 266265014325 dimer interface [polypeptide binding]; other site 266265014326 TPP binding site [chemical binding]; other site 266265014327 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266265014328 pteridine reductase; Provisional; Region: PRK09135 266265014329 classical (c) SDRs; Region: SDR_c; cd05233 266265014330 NAD(P) binding site [chemical binding]; other site 266265014331 active site 266265014332 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265014333 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265014334 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265014335 catalytic site [active] 266265014336 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 266265014337 transcriptional regulator; Provisional; Region: PRK10632 266265014338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014339 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265014340 putative effector binding pocket; other site 266265014341 dimerization interface [polypeptide binding]; other site 266265014342 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265014343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265014344 NAD(P) binding site [chemical binding]; other site 266265014345 active site 266265014346 Methyltransferase domain; Region: Methyltransf_25; pfam13649 266265014347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266265014348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265014349 dimer interface [polypeptide binding]; other site 266265014350 phosphorylation site [posttranslational modification] 266265014351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265014352 ATP binding site [chemical binding]; other site 266265014353 Mg2+ binding site [ion binding]; other site 266265014354 G-X-G motif; other site 266265014355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265014356 Response regulator receiver domain; Region: Response_reg; pfam00072 266265014357 active site 266265014358 phosphorylation site [posttranslational modification] 266265014359 intermolecular recognition site; other site 266265014360 dimerization interface [polypeptide binding]; other site 266265014361 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265014362 Response regulator receiver domain; Region: Response_reg; pfam00072 266265014363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265014364 active site 266265014365 phosphorylation site [posttranslational modification] 266265014366 intermolecular recognition site; other site 266265014367 dimerization interface [polypeptide binding]; other site 266265014368 classical (c) SDRs; Region: SDR_c; cd05233 266265014369 NAD(P) binding site [chemical binding]; other site 266265014370 active site 266265014371 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265014372 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266265014373 Sel1-like repeats; Region: SEL1; smart00671 266265014374 Sel1-like repeats; Region: SEL1; smart00671 266265014375 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266265014376 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266265014377 Sel1-like repeats; Region: SEL1; smart00671 266265014378 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266265014379 HAMP domain; Region: HAMP; pfam00672 266265014380 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265014381 dimer interface [polypeptide binding]; other site 266265014382 putative CheW interface [polypeptide binding]; other site 266265014383 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266265014384 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266265014385 Multicopper oxidase; Region: Cu-oxidase; pfam00394 266265014386 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266265014387 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265014388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265014389 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265014390 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266265014391 putative NAD(P) binding site [chemical binding]; other site 266265014392 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265014393 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265014394 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 266265014395 inhibitor-cofactor binding pocket; inhibition site 266265014396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265014397 catalytic residue [active] 266265014398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265014399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014400 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 266265014401 putative dimerization interface [polypeptide binding]; other site 266265014402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265014403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265014404 transcriptional regulator; Provisional; Region: PRK10632 266265014405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014406 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 266265014407 putative effector binding pocket; other site 266265014408 putative dimerization interface [polypeptide binding]; other site 266265014409 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266265014410 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266265014411 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265014412 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 266265014413 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 266265014414 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 266265014415 putative ion selectivity filter; other site 266265014416 putative pore gating glutamate residue; other site 266265014417 putative H+/Cl- coupling transport residue; other site 266265014418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265014419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014420 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265014421 putative effector binding pocket; other site 266265014422 dimerization interface [polypeptide binding]; other site 266265014423 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 266265014424 putative catalytic residues [active] 266265014425 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265014426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265014427 NAD(P) binding site [chemical binding]; other site 266265014428 active site 266265014429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265014430 dimerization interface [polypeptide binding]; other site 266265014431 putative DNA binding site [nucleotide binding]; other site 266265014432 putative Zn2+ binding site [ion binding]; other site 266265014433 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 266265014434 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 266265014435 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 266265014436 trimer interface [polypeptide binding]; other site 266265014437 putative Zn binding site [ion binding]; other site 266265014438 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266265014439 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265014440 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 266265014441 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265014442 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265014443 substrate binding pocket [chemical binding]; other site 266265014444 membrane-bound complex binding site; other site 266265014445 hinge residues; other site 266265014446 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 266265014447 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 266265014448 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 266265014449 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265014450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265014451 dimer interface [polypeptide binding]; other site 266265014452 conserved gate region; other site 266265014453 putative PBP binding loops; other site 266265014454 ABC-ATPase subunit interface; other site 266265014455 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265014456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266265014457 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265014458 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265014459 Walker A/P-loop; other site 266265014460 ATP binding site [chemical binding]; other site 266265014461 Q-loop/lid; other site 266265014462 ABC transporter signature motif; other site 266265014463 Walker B; other site 266265014464 D-loop; other site 266265014465 H-loop/switch region; other site 266265014466 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 266265014467 allantoicase; Provisional; Region: PRK13257 266265014468 Allantoicase repeat; Region: Allantoicase; pfam03561 266265014469 Allantoicase repeat; Region: Allantoicase; pfam03561 266265014470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265014471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265014472 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266265014473 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266265014474 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 266265014475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265014476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265014477 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265014478 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265014479 active site 266265014480 catalytic tetrad [active] 266265014481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 266265014482 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 266265014483 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 266265014484 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 266265014485 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 266265014486 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 266265014487 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266265014488 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266265014489 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266265014490 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266265014491 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 266265014492 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266265014493 Di-iron ligands [ion binding]; other site 266265014494 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266265014495 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266265014496 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265014497 hypothetical protein; Provisional; Region: PRK06834 266265014498 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265014499 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265014500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265014501 dimer interface [polypeptide binding]; other site 266265014502 conserved gate region; other site 266265014503 putative PBP binding loops; other site 266265014504 ABC-ATPase subunit interface; other site 266265014505 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265014506 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265014507 Walker A/P-loop; other site 266265014508 ATP binding site [chemical binding]; other site 266265014509 Q-loop/lid; other site 266265014510 ABC transporter signature motif; other site 266265014511 Walker B; other site 266265014512 D-loop; other site 266265014513 H-loop/switch region; other site 266265014514 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265014515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265014516 substrate binding pocket [chemical binding]; other site 266265014517 membrane-bound complex binding site; other site 266265014518 hinge residues; other site 266265014519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265014520 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266265014521 active site 266265014522 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266265014523 active site 266265014524 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266265014525 dimer interface [polypeptide binding]; other site 266265014526 non-prolyl cis peptide bond; other site 266265014527 insertion regions; other site 266265014528 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266265014529 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266265014530 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265014531 P-loop; other site 266265014532 Magnesium ion binding site [ion binding]; other site 266265014533 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265014534 Magnesium ion binding site [ion binding]; other site 266265014535 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 266265014536 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265014537 ligand binding site [chemical binding]; other site 266265014538 flexible hinge region; other site 266265014539 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266265014540 putative switch regulator; other site 266265014541 non-specific DNA interactions [nucleotide binding]; other site 266265014542 DNA binding site [nucleotide binding] 266265014543 sequence specific DNA binding site [nucleotide binding]; other site 266265014544 putative cAMP binding site [chemical binding]; other site 266265014545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 266265014546 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 266265014547 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265014548 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265014549 dimer interface [polypeptide binding]; other site 266265014550 putative CheW interface [polypeptide binding]; other site 266265014551 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 266265014552 heme-binding site [chemical binding]; other site 266265014553 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266265014554 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265014555 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265014556 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265014557 metal binding site [ion binding]; metal-binding site 266265014558 active site 266265014559 I-site; other site 266265014560 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265014561 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 266265014562 active site 266265014563 catalytic residues [active] 266265014564 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 266265014565 putative dimerization interface [polypeptide binding]; other site 266265014566 putative ligand binding site [chemical binding]; other site 266265014567 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265014568 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265014569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265014570 xylose isomerase; Provisional; Region: PRK05474 266265014571 xylose isomerase; Region: xylose_isom_A; TIGR02630 266265014572 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 266265014573 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 266265014574 putative ligand binding site [chemical binding]; other site 266265014575 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 266265014576 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265014577 Walker A/P-loop; other site 266265014578 ATP binding site [chemical binding]; other site 266265014579 Q-loop/lid; other site 266265014580 ABC transporter signature motif; other site 266265014581 Walker B; other site 266265014582 D-loop; other site 266265014583 H-loop/switch region; other site 266265014584 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265014585 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265014586 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265014587 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265014588 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265014589 TM-ABC transporter signature motif; other site 266265014590 TPR repeat; Region: TPR_11; pfam13414 266265014591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265014592 binding surface 266265014593 TPR motif; other site 266265014594 TPR repeat; Region: TPR_11; pfam13414 266265014595 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265014596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265014597 TPR motif; other site 266265014598 binding surface 266265014599 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265014600 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265014601 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265014602 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265014603 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265014604 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265014605 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265014606 catalytic loop [active] 266265014607 iron binding site [ion binding]; other site 266265014608 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265014609 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265014610 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 266265014611 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265014612 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265014613 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 266265014614 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266265014615 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265014616 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 266265014617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265014618 dimer interface [polypeptide binding]; other site 266265014619 phosphorylation site [posttranslational modification] 266265014620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265014621 ATP binding site [chemical binding]; other site 266265014622 G-X-G motif; other site 266265014623 Response regulator receiver domain; Region: Response_reg; pfam00072 266265014624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265014625 active site 266265014626 phosphorylation site [posttranslational modification] 266265014627 intermolecular recognition site; other site 266265014628 dimerization interface [polypeptide binding]; other site 266265014629 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 266265014630 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265014631 Walker A motif; other site 266265014632 ATP binding site [chemical binding]; other site 266265014633 Walker B motif; other site 266265014634 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265014635 Walker A motif; other site 266265014636 ATP binding site [chemical binding]; other site 266265014637 Walker B motif; other site 266265014638 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266265014639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014640 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 266265014641 putative dimerization interface [polypeptide binding]; other site 266265014642 putative substrate binding pocket [chemical binding]; other site 266265014643 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265014644 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265014645 trimer interface [polypeptide binding]; other site 266265014646 eyelet of channel; other site 266265014647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265014648 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265014649 putative substrate translocation pore; other site 266265014650 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 266265014651 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 266265014652 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266265014653 RHS Repeat; Region: RHS_repeat; pfam05593 266265014654 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 266265014655 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 266265014656 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 266265014657 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 266265014658 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266265014659 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 266265014660 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 266265014661 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 266265014662 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 266265014663 putative active site [active] 266265014664 catalytic site [active] 266265014665 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266265014666 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266265014667 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266265014668 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266265014669 PAAR motif; Region: PAAR_motif; pfam05488 266265014670 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 266265014671 Predicted membrane protein [Function unknown]; Region: COG1289 266265014672 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265014673 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 266265014674 Uncharacterized conserved protein [Function unknown]; Region: COG3777 266265014675 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266265014676 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 266265014677 putative active site [active] 266265014678 putative catalytic site [active] 266265014679 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265014680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265014681 active site 266265014682 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265014683 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265014684 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266265014685 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266265014686 Response regulator receiver domain; Region: Response_reg; pfam00072 266265014687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265014688 active site 266265014689 phosphorylation site [posttranslational modification] 266265014690 intermolecular recognition site; other site 266265014691 dimerization interface [polypeptide binding]; other site 266265014692 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265014693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014694 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266265014695 putative dimerization interface [polypeptide binding]; other site 266265014696 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 266265014697 aldehyde dehydrogenase family 7 member; Region: PLN02315 266265014698 tetrameric interface [polypeptide binding]; other site 266265014699 NAD binding site [chemical binding]; other site 266265014700 catalytic residues [active] 266265014701 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265014702 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265014703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265014704 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 266265014705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265014706 homodimer interface [polypeptide binding]; other site 266265014707 catalytic residue [active] 266265014708 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909 266265014709 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 266265014710 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 266265014711 MG2 domain; Region: A2M_N; pfam01835 266265014712 Alpha-2-macroglobulin family; Region: A2M; pfam00207 266265014713 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 266265014714 Predicted secreted protein [Function unknown]; Region: COG5445 266265014715 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 266265014716 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 266265014717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 266265014718 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 266265014719 PRC-barrel domain; Region: PRC; pfam05239 266265014720 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266265014721 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266265014722 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266265014723 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266265014724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265014725 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266265014726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265014727 DNA binding residues [nucleotide binding] 266265014728 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265014729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265014730 DNA-binding site [nucleotide binding]; DNA binding site 266265014731 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266265014732 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265014733 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266265014734 putative ligand binding site [chemical binding]; other site 266265014735 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265014736 TM-ABC transporter signature motif; other site 266265014737 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265014738 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265014739 TM-ABC transporter signature motif; other site 266265014740 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265014741 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265014742 Walker A/P-loop; other site 266265014743 ATP binding site [chemical binding]; other site 266265014744 Q-loop/lid; other site 266265014745 ABC transporter signature motif; other site 266265014746 Walker B; other site 266265014747 D-loop; other site 266265014748 H-loop/switch region; other site 266265014749 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265014750 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265014751 Walker A/P-loop; other site 266265014752 ATP binding site [chemical binding]; other site 266265014753 Q-loop/lid; other site 266265014754 ABC transporter signature motif; other site 266265014755 Walker B; other site 266265014756 D-loop; other site 266265014757 H-loop/switch region; other site 266265014758 allantoate amidohydrolase; Reviewed; Region: PRK12893 266265014759 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266265014760 active site 266265014761 metal binding site [ion binding]; metal-binding site 266265014762 dimer interface [polypeptide binding]; other site 266265014763 Uncharacterized conserved protein [Function unknown]; Region: COG5476 266265014764 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 266265014765 MlrC C-terminus; Region: MlrC_C; pfam07171 266265014766 dihydroxyacetone kinase; Provisional; Region: PRK14479 266265014767 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 266265014768 DAK2 domain; Region: Dak2; pfam02734 266265014769 Predicted permease; Region: DUF318; cl17795 266265014770 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 266265014771 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265014772 active site residue [active] 266265014773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266265014774 selenophosphate synthetase; Provisional; Region: PRK00943 266265014775 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 266265014776 dimerization interface [polypeptide binding]; other site 266265014777 putative ATP binding site [chemical binding]; other site 266265014778 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266265014779 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266265014780 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266265014781 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 266265014782 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 266265014783 molybdopterin cofactor binding site; other site 266265014784 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 266265014785 4Fe-4S binding domain; Region: Fer4; cl02805 266265014786 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 266265014787 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266265014788 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 266265014789 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 266265014790 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 266265014791 selenocysteine synthase; Provisional; Region: PRK04311 266265014792 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 266265014793 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 266265014794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265014795 catalytic residue [active] 266265014796 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 266265014797 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 266265014798 G1 box; other site 266265014799 putative GEF interaction site [polypeptide binding]; other site 266265014800 GTP/Mg2+ binding site [chemical binding]; other site 266265014801 Switch I region; other site 266265014802 G2 box; other site 266265014803 G3 box; other site 266265014804 Switch II region; other site 266265014805 G4 box; other site 266265014806 G5 box; other site 266265014807 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 266265014808 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 266265014809 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 266265014810 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 266265014811 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266265014812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265014814 dimerization interface [polypeptide binding]; other site 266265014815 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265014816 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 266265014817 NAD(P) binding site [chemical binding]; other site 266265014818 catalytic residues [active] 266265014819 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266265014820 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266265014821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265014822 dimer interface [polypeptide binding]; other site 266265014823 conserved gate region; other site 266265014824 putative PBP binding loops; other site 266265014825 ABC-ATPase subunit interface; other site 266265014826 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265014827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265014828 dimer interface [polypeptide binding]; other site 266265014829 conserved gate region; other site 266265014830 putative PBP binding loops; other site 266265014831 ABC-ATPase subunit interface; other site 266265014832 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266265014833 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265014834 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265014835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265014836 Walker A/P-loop; other site 266265014837 ATP binding site [chemical binding]; other site 266265014838 Q-loop/lid; other site 266265014839 ABC transporter signature motif; other site 266265014840 Walker B; other site 266265014841 D-loop; other site 266265014842 H-loop/switch region; other site 266265014843 TOBE domain; Region: TOBE_2; pfam08402 266265014844 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265014845 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265014846 acyl-activating enzyme (AAE) consensus motif; other site 266265014847 AMP binding site [chemical binding]; other site 266265014848 active site 266265014849 CoA binding site [chemical binding]; other site 266265014850 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 266265014851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265014852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265014854 dimerization interface [polypeptide binding]; other site 266265014855 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 266265014856 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265014857 substrate binding site [chemical binding]; other site 266265014858 trimer interface [polypeptide binding]; other site 266265014859 oxyanion hole (OAH) forming residues; other site 266265014860 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265014861 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265014862 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265014863 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265014864 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265014865 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 266265014866 putative hydrophobic ligand binding site [chemical binding]; other site 266265014867 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265014868 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266265014869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265014870 fumarylacetoacetase; Region: PLN02856 266265014871 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 266265014872 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265014873 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 266265014874 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265014875 Zn binding site [ion binding]; other site 266265014876 salicylate hydroxylase; Provisional; Region: PRK08163 266265014877 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265014878 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 266265014879 Flavoprotein; Region: Flavoprotein; pfam02441 266265014880 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265014881 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265014882 trimer interface [polypeptide binding]; other site 266265014883 eyelet of channel; other site 266265014884 benzoate transport; Region: 2A0115; TIGR00895 266265014885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265014886 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 266265014887 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266265014888 substrate binding site [chemical binding]; other site 266265014889 ligand binding site [chemical binding]; other site 266265014890 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266265014891 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266265014892 substrate binding site [chemical binding]; other site 266265014893 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266265014894 Tar ligand binding domain homologue; Region: TarH; pfam02203 266265014895 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266265014896 HAMP domain; Region: HAMP; pfam00672 266265014897 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265014898 dimer interface [polypeptide binding]; other site 266265014899 putative CheW interface [polypeptide binding]; other site 266265014900 benzoate transport; Region: 2A0115; TIGR00895 266265014901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265014902 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266265014903 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265014904 NAD(P) binding site [chemical binding]; other site 266265014905 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265014906 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265014907 acyl-activating enzyme (AAE) consensus motif; other site 266265014908 AMP binding site [chemical binding]; other site 266265014909 active site 266265014910 CoA binding site [chemical binding]; other site 266265014911 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266265014912 CoenzymeA binding site [chemical binding]; other site 266265014913 subunit interaction site [polypeptide binding]; other site 266265014914 PHB binding site; other site 266265014915 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266265014916 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 266265014917 NMT1/THI5 like; Region: NMT1; pfam09084 266265014918 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265014919 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265014920 trimer interface [polypeptide binding]; other site 266265014921 eyelet of channel; other site 266265014922 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265014923 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265014924 trimer interface [polypeptide binding]; other site 266265014925 eyelet of channel; other site 266265014926 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266265014927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265014928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014929 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266265014930 putative dimerization interface [polypeptide binding]; other site 266265014931 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265014932 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265014933 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265014934 catalytic loop [active] 266265014935 iron binding site [ion binding]; other site 266265014936 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265014937 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265014938 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265014939 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265014940 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265014941 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265014942 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265014943 Cytochrome c; Region: Cytochrom_C; pfam00034 266265014944 tricarballylate utilization protein B; Provisional; Region: PRK15033 266265014945 tricarballylate dehydrogenase; Validated; Region: PRK08274 266265014946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265014947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265014948 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266265014949 putative dimerization interface [polypeptide binding]; other site 266265014950 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265014951 PYR/PP interface [polypeptide binding]; other site 266265014952 dimer interface [polypeptide binding]; other site 266265014953 TPP binding site [chemical binding]; other site 266265014954 hypothetical protein; Provisional; Region: PRK06163 266265014955 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266265014956 TPP-binding site [chemical binding]; other site 266265014957 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265014958 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 266265014959 NAD(P) binding site [chemical binding]; other site 266265014960 catalytic residues [active] 266265014961 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266265014962 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266265014963 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266265014964 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266265014965 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266265014966 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 266265014967 homotrimer interaction site [polypeptide binding]; other site 266265014968 putative active site [active] 266265014969 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266265014970 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 266265014971 dimer interface [polypeptide binding]; other site 266265014972 ligand binding site [chemical binding]; other site 266265014973 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266265014974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265014975 dimerization interface [polypeptide binding]; other site 266265014976 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265014977 dimer interface [polypeptide binding]; other site 266265014978 putative CheW interface [polypeptide binding]; other site 266265014979 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 266265014980 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 266265014981 active site 266265014982 homotetramer interface [polypeptide binding]; other site 266265014983 homodimer interface [polypeptide binding]; other site 266265014984 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266265014985 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 266265014986 ATP binding site [chemical binding]; other site 266265014987 Mg2+ binding site [ion binding]; other site 266265014988 G-X-G motif; other site 266265014989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265014990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265014991 dimer interface [polypeptide binding]; other site 266265014992 phosphorylation site [posttranslational modification] 266265014993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265014994 ATP binding site [chemical binding]; other site 266265014995 Mg2+ binding site [ion binding]; other site 266265014996 G-X-G motif; other site 266265014997 Response regulator receiver domain; Region: Response_reg; pfam00072 266265014998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265014999 active site 266265015000 phosphorylation site [posttranslational modification] 266265015001 intermolecular recognition site; other site 266265015002 dimerization interface [polypeptide binding]; other site 266265015003 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 266265015004 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 266265015005 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 266265015006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265015007 ATP binding site [chemical binding]; other site 266265015008 Mg2+ binding site [ion binding]; other site 266265015009 G-X-G motif; other site 266265015010 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 266265015011 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 266265015012 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 266265015013 WxcM-like, C-terminal; Region: FdtA; pfam05523 266265015014 Bacterial Ig-like domain; Region: Big_5; pfam13205 266265015015 Bacterial Ig-like domain; Region: Big_5; pfam13205 266265015016 Bacterial Ig-like domain; Region: Big_5; pfam13205 266265015017 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 266265015018 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 266265015019 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266265015020 NAD binding site [chemical binding]; other site 266265015021 catalytic Zn binding site [ion binding]; other site 266265015022 structural Zn binding site [ion binding]; other site 266265015023 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266265015024 Hemerythrin-like domain; Region: Hr-like; cd12108 266265015025 phosphoglycolate phosphatase; Provisional; Region: PRK13222 266265015026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265015027 motif II; other site 266265015028 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266265015029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265015030 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265015031 TolR protein; Region: tolR; TIGR02801 266265015032 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 266265015033 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266265015034 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266265015035 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 266265015036 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 266265015037 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 266265015038 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 266265015039 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265015040 N-terminal plug; other site 266265015041 ligand-binding site [chemical binding]; other site 266265015042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266265015043 Histidine kinase; Region: HisKA_3; pfam07730 266265015044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265015045 ATP binding site [chemical binding]; other site 266265015046 Mg2+ binding site [ion binding]; other site 266265015047 G-X-G motif; other site 266265015048 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265015049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265015050 active site 266265015051 phosphorylation site [posttranslational modification] 266265015052 intermolecular recognition site; other site 266265015053 dimerization interface [polypeptide binding]; other site 266265015054 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265015055 DNA binding residues [nucleotide binding] 266265015056 dimerization interface [polypeptide binding]; other site 266265015057 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 266265015058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265015059 FeS/SAM binding site; other site 266265015060 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 266265015061 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 266265015062 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 266265015063 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 266265015064 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 266265015065 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 266265015066 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266265015067 FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980 266265015068 putative subunit interface; other site 266265015069 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 266265015070 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 266265015071 FTR, proximal lobe; Region: FTR_C; pfam02741 266265015072 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 266265015073 Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304 266265015074 active site 266265015075 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266265015076 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 266265015077 molybdopterin cofactor binding site; other site 266265015078 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 266265015079 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 266265015080 active site 266265015081 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 266265015082 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266265015083 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 266265015084 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 266265015085 nucleotide binding site [chemical binding]; other site 266265015086 substrate binding site [chemical binding]; other site 266265015087 hypothetical protein; Provisional; Region: PRK02227 266265015088 Protein of unknown function (DUF447); Region: DUF447; pfam04289 266265015089 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 266265015090 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 266265015091 homodimer interface [polypeptide binding]; other site 266265015092 active site 266265015093 heterodimer interface [polypeptide binding]; other site 266265015094 catalytic residue [active] 266265015095 metal binding site [ion binding]; metal-binding site 266265015096 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 266265015097 multimerization interface [polypeptide binding]; other site 266265015098 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 266265015099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265015100 Walker A motif; other site 266265015101 ATP binding site [chemical binding]; other site 266265015102 Walker B motif; other site 266265015103 arginine finger; other site 266265015104 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 266265015105 AMP binding site [chemical binding]; other site 266265015106 metal binding site [ion binding]; metal-binding site 266265015107 active site 266265015108 phosphoribulokinase; Provisional; Region: PRK15453 266265015109 transketolase; Reviewed; Region: PRK12753 266265015110 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266265015111 TPP-binding site [chemical binding]; other site 266265015112 dimer interface [polypeptide binding]; other site 266265015113 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266265015114 PYR/PP interface [polypeptide binding]; other site 266265015115 dimer interface [polypeptide binding]; other site 266265015116 TPP binding site [chemical binding]; other site 266265015117 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266265015118 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 266265015119 intersubunit interface [polypeptide binding]; other site 266265015120 active site 266265015121 zinc binding site [ion binding]; other site 266265015122 Na+ binding site [ion binding]; other site 266265015123 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 266265015124 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 266265015125 substrate binding site [chemical binding]; other site 266265015126 hexamer interface [polypeptide binding]; other site 266265015127 metal binding site [ion binding]; metal-binding site 266265015128 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 266265015129 putative di-iron ligands [ion binding]; other site 266265015130 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 266265015131 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 266265015132 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265015133 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265015134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265015135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265015136 dihydropteroate synthase-related protein; Region: TIGR00284 266265015137 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 266265015138 substrate binding pocket [chemical binding]; other site 266265015139 dimer interface [polypeptide binding]; other site 266265015140 inhibitor binding site; inhibition site 266265015141 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 266265015142 Flavoprotein; Region: Flavoprotein; pfam02441 266265015143 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 266265015144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265015145 Walker A motif; other site 266265015146 ATP binding site [chemical binding]; other site 266265015147 Walker B motif; other site 266265015148 arginine finger; other site 266265015149 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265015150 Dihydroneopterin aldolase; Region: FolB; smart00905 266265015151 active site 266265015152 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 266265015153 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 266265015154 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 266265015155 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266265015156 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 266265015157 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 266265015158 trimer interface I [polypeptide binding]; other site 266265015159 putative substrate binding pocket [chemical binding]; other site 266265015160 trimer interface II [polypeptide binding]; other site 266265015161 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 266265015162 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266265015163 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 266265015164 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 266265015165 NAD(P) binding pocket [chemical binding]; other site 266265015166 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 266265015167 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 266265015168 aromatic arch; other site 266265015169 DCoH dimer interaction site [polypeptide binding]; other site 266265015170 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 266265015171 DCoH tetramer interaction site [polypeptide binding]; other site 266265015172 substrate binding site [chemical binding]; other site 266265015173 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 266265015174 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 266265015175 Trp docking motif [polypeptide binding]; other site 266265015176 dimer interface [polypeptide binding]; other site 266265015177 active site 266265015178 small subunit binding site [polypeptide binding]; other site 266265015179 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266265015180 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 266265015181 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265015182 membrane-bound complex binding site; other site 266265015183 hinge residues; other site 266265015184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265015185 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015186 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 266265015187 putative dimerization interface [polypeptide binding]; other site 266265015188 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 266265015189 MoxR-like ATPases [General function prediction only]; Region: COG0714 266265015190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266265015191 Protein of unknown function DUF58; Region: DUF58; pfam01882 266265015192 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266265015193 metal ion-dependent adhesion site (MIDAS); other site 266265015194 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 266265015195 von Willebrand factor type A domain; Region: VWA_2; pfam13519 266265015196 metal ion-dependent adhesion site (MIDAS); other site 266265015197 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 266265015198 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 266265015199 Trp docking motif [polypeptide binding]; other site 266265015200 active site 266265015201 Cytochrome c553 [Energy production and conversion]; Region: COG2863 266265015202 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265015203 Cytochrome c; Region: Cytochrom_C; cl11414 266265015204 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 266265015205 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266265015206 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266265015207 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 266265015208 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266265015209 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265015210 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 266265015211 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265015212 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266265015213 active site 266265015214 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266265015215 dimer interface [polypeptide binding]; other site 266265015216 non-prolyl cis peptide bond; other site 266265015217 insertion regions; other site 266265015218 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 266265015219 active site residue [active] 266265015220 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265015221 active site residue [active] 266265015222 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265015223 active site residue [active] 266265015224 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265015225 active site residue [active] 266265015226 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265015227 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265015228 active site 266265015229 non-prolyl cis peptide bond; other site 266265015230 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265015231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265015232 dimer interface [polypeptide binding]; other site 266265015233 conserved gate region; other site 266265015234 putative PBP binding loops; other site 266265015235 ABC-ATPase subunit interface; other site 266265015236 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265015237 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265015238 Walker A/P-loop; other site 266265015239 ATP binding site [chemical binding]; other site 266265015240 Q-loop/lid; other site 266265015241 ABC transporter signature motif; other site 266265015242 Walker B; other site 266265015243 D-loop; other site 266265015244 H-loop/switch region; other site 266265015245 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265015246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265015247 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265015248 active site residue [active] 266265015249 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265015250 active site residue [active] 266265015251 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 266265015252 active site residue [active] 266265015253 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265015254 active site residue [active] 266265015255 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 266265015256 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265015257 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265015258 trimer interface [polypeptide binding]; other site 266265015259 eyelet of channel; other site 266265015260 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265015261 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265015262 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 266265015263 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 266265015264 putative dimer interface [polypeptide binding]; other site 266265015265 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266265015266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015267 putative substrate translocation pore; other site 266265015268 hypothetical protein; Provisional; Region: PRK07236 266265015269 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266265015270 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 266265015271 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266265015272 catalytic residues [active] 266265015273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265015274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015275 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265015276 putative effector binding pocket; other site 266265015277 dimerization interface [polypeptide binding]; other site 266265015278 Isochorismatase family; Region: Isochorismatase; pfam00857 266265015279 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266265015280 catalytic triad [active] 266265015281 dimer interface [polypeptide binding]; other site 266265015282 conserved cis-peptide bond; other site 266265015283 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266265015284 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266265015285 active site 266265015286 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266265015287 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266265015288 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265015289 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265015290 ligand binding site [chemical binding]; other site 266265015291 flexible hinge region; other site 266265015292 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 266265015293 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 266265015294 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266265015295 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 266265015296 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265015297 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265015298 ligand binding site [chemical binding]; other site 266265015299 flexible hinge region; other site 266265015300 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 266265015301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265015302 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265015303 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265015304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265015305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265015306 DNA binding site [nucleotide binding] 266265015307 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266265015308 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265015309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265015310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265015311 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266265015312 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 266265015313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265015314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265015315 DNA binding site [nucleotide binding] 266265015316 Predicted ATPase [General function prediction only]; Region: COG3903 266265015317 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 266265015318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265015320 dimerization interface [polypeptide binding]; other site 266265015321 pyruvate dehydrogenase; Provisional; Region: PRK09124 266265015322 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 266265015323 PYR/PP interface [polypeptide binding]; other site 266265015324 dimer interface [polypeptide binding]; other site 266265015325 tetramer interface [polypeptide binding]; other site 266265015326 TPP binding site [chemical binding]; other site 266265015327 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265015328 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 266265015329 TPP-binding site [chemical binding]; other site 266265015330 PRC-barrel domain; Region: PRC; pfam05239 266265015331 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265015332 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265015333 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266265015334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015335 putative substrate translocation pore; other site 266265015336 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 266265015337 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265015338 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266265015339 hydrophobic ligand binding site; other site 266265015340 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265015341 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266265015342 FMN-binding pocket [chemical binding]; other site 266265015343 flavin binding motif; other site 266265015344 phosphate binding motif [ion binding]; other site 266265015345 beta-alpha-beta structure motif; other site 266265015346 NAD binding pocket [chemical binding]; other site 266265015347 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265015348 catalytic loop [active] 266265015349 iron binding site [ion binding]; other site 266265015350 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265015351 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265015352 lipid-transfer protein; Provisional; Region: PRK07855 266265015353 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265015354 active site 266265015355 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266265015356 DUF35 OB-fold domain; Region: DUF35; pfam01796 266265015357 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265015358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265015359 DNA-binding site [nucleotide binding]; DNA binding site 266265015360 FCD domain; Region: FCD; pfam07729 266265015361 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265015362 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265015363 trimer interface [polypeptide binding]; other site 266265015364 eyelet of channel; other site 266265015365 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266265015366 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 266265015367 NAD(P) binding site [chemical binding]; other site 266265015368 catalytic residues [active] 266265015369 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265015370 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265015371 trimer interface [polypeptide binding]; other site 266265015372 eyelet of channel; other site 266265015373 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265015374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265015375 DNA-binding site [nucleotide binding]; DNA binding site 266265015376 FCD domain; Region: FCD; pfam07729 266265015377 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265015378 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265015379 Walker A/P-loop; other site 266265015380 ATP binding site [chemical binding]; other site 266265015381 Q-loop/lid; other site 266265015382 ABC transporter signature motif; other site 266265015383 Walker B; other site 266265015384 D-loop; other site 266265015385 H-loop/switch region; other site 266265015386 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265015387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265015388 dimer interface [polypeptide binding]; other site 266265015389 conserved gate region; other site 266265015390 putative PBP binding loops; other site 266265015391 ABC-ATPase subunit interface; other site 266265015392 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 266265015393 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265015394 NAD(P) binding site [chemical binding]; other site 266265015395 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266265015396 CoenzymeA binding site [chemical binding]; other site 266265015397 subunit interaction site [polypeptide binding]; other site 266265015398 PHB binding site; other site 266265015399 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 266265015400 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265015401 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265015402 acyl-activating enzyme (AAE) consensus motif; other site 266265015403 AMP binding site [chemical binding]; other site 266265015404 active site 266265015405 CoA binding site [chemical binding]; other site 266265015406 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 266265015407 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265015408 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266265015409 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 266265015410 Flavoprotein; Region: Flavoprotein; pfam02441 266265015411 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265015412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265015413 DNA-binding site [nucleotide binding]; DNA binding site 266265015414 FCD domain; Region: FCD; pfam07729 266265015415 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265015416 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265015417 membrane-bound complex binding site; other site 266265015418 hinge residues; other site 266265015419 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265015420 iron-sulfur cluster [ion binding]; other site 266265015421 [2Fe-2S] cluster binding site [ion binding]; other site 266265015422 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 266265015423 putative alpha subunit interface [polypeptide binding]; other site 266265015424 putative active site [active] 266265015425 putative substrate binding site [chemical binding]; other site 266265015426 Fe binding site [ion binding]; other site 266265015427 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265015428 inter-subunit interface; other site 266265015429 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 266265015430 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 266265015431 NAD binding site [chemical binding]; other site 266265015432 ligand binding site [chemical binding]; other site 266265015433 catalytic site [active] 266265015434 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 266265015435 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266265015436 HSP70 interaction site [polypeptide binding]; other site 266265015437 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 266265015438 substrate binding site [polypeptide binding]; other site 266265015439 dimer interface [polypeptide binding]; other site 266265015440 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 266265015441 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 266265015442 FOG: CBS domain [General function prediction only]; Region: COG0517 266265015443 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 266265015444 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 266265015445 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266265015446 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 266265015447 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266265015448 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266265015449 Walker A/P-loop; other site 266265015450 ATP binding site [chemical binding]; other site 266265015451 Q-loop/lid; other site 266265015452 ABC transporter signature motif; other site 266265015453 Walker B; other site 266265015454 D-loop; other site 266265015455 H-loop/switch region; other site 266265015456 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266265015457 Walker A/P-loop; other site 266265015458 ATP binding site [chemical binding]; other site 266265015459 Q-loop/lid; other site 266265015460 ABC transporter signature motif; other site 266265015461 Walker B; other site 266265015462 D-loop; other site 266265015463 H-loop/switch region; other site 266265015464 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266265015465 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 266265015466 HlyD family secretion protein; Region: HlyD; pfam00529 266265015467 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265015468 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265015469 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265015470 phasin family protein; Region: phasin; TIGR01841 266265015471 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 266265015472 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 266265015473 heme-binding site [chemical binding]; other site 266265015474 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 266265015475 FAD binding pocket [chemical binding]; other site 266265015476 FAD binding motif [chemical binding]; other site 266265015477 phosphate binding motif [ion binding]; other site 266265015478 beta-alpha-beta structure motif; other site 266265015479 NAD binding pocket [chemical binding]; other site 266265015480 Heme binding pocket [chemical binding]; other site 266265015481 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 266265015482 GAF domain; Region: GAF; pfam01590 266265015483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265015484 Walker A motif; other site 266265015485 ATP binding site [chemical binding]; other site 266265015486 Walker B motif; other site 266265015487 arginine finger; other site 266265015488 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 266265015489 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265015490 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265015491 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265015492 FAD binding domain; Region: FAD_binding_3; pfam01494 266265015493 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 266265015494 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 266265015495 active site 266265015496 metal binding site [ion binding]; metal-binding site 266265015497 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265015498 acetaldehyde dehydrogenase; Validated; Region: PRK08300 266265015499 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266265015500 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 266265015501 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 266265015502 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 266265015503 active site 266265015504 catalytic residues [active] 266265015505 metal binding site [ion binding]; metal-binding site 266265015506 DmpG-like communication domain; Region: DmpG_comm; pfam07836 266265015507 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 266265015508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015509 putative substrate translocation pore; other site 266265015510 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 266265015511 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266265015512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265015513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265015514 short chain dehydrogenase; Provisional; Region: PRK06500 266265015515 classical (c) SDRs; Region: SDR_c; cd05233 266265015516 NAD(P) binding site [chemical binding]; other site 266265015517 active site 266265015518 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 266265015519 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266265015520 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265015521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265015522 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265015523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265015524 hypothetical protein; Validated; Region: PRK06201 266265015525 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 266265015526 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265015527 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266265015528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015529 putative substrate translocation pore; other site 266265015530 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266265015531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015532 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266265015533 dimerization interface [polypeptide binding]; other site 266265015534 substrate binding pocket [chemical binding]; other site 266265015535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265015536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015537 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 266265015538 substrate binding pocket [chemical binding]; other site 266265015539 dimerization interface [polypeptide binding]; other site 266265015540 Flavin Reductases; Region: FlaRed; cl00801 266265015541 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265015542 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265015543 active site 266265015544 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265015545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015546 putative substrate translocation pore; other site 266265015547 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266265015548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265015549 motif II; other site 266265015550 benzoate transport; Region: 2A0115; TIGR00895 266265015551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015552 putative substrate translocation pore; other site 266265015553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015554 Propionate catabolism activator; Region: PrpR_N; pfam06506 266265015555 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 266265015556 PAS domain; Region: PAS; smart00091 266265015557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265015558 Walker A motif; other site 266265015559 ATP binding site [chemical binding]; other site 266265015560 Walker B motif; other site 266265015561 arginine finger; other site 266265015562 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265015563 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266265015564 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 266265015565 dimer interface [polypeptide binding]; other site 266265015566 active site 266265015567 citrylCoA binding site [chemical binding]; other site 266265015568 oxalacetate/citrate binding site [chemical binding]; other site 266265015569 coenzyme A binding site [chemical binding]; other site 266265015570 catalytic triad [active] 266265015571 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 266265015572 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 266265015573 substrate binding site [chemical binding]; other site 266265015574 ligand binding site [chemical binding]; other site 266265015575 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 266265015576 substrate binding site [chemical binding]; other site 266265015577 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 266265015578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 266265015579 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266265015580 metal-binding site [ion binding] 266265015581 Outer membrane efflux protein; Region: OEP; pfam02321 266265015582 Outer membrane efflux protein; Region: OEP; pfam02321 266265015583 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266265015584 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266265015585 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266265015586 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 266265015587 Nodulation protein Z (NodZ); Region: NodZ; pfam05830 266265015588 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 266265015589 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266265015590 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265015591 putative NAD(P) binding site [chemical binding]; other site 266265015592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015593 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265015594 putative substrate translocation pore; other site 266265015595 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265015596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265015597 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 266265015598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265015599 Walker A motif; other site 266265015600 ATP binding site [chemical binding]; other site 266265015601 Walker B motif; other site 266265015602 arginine finger; other site 266265015603 Peptidase family M41; Region: Peptidase_M41; pfam01434 266265015604 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265015605 OpgC protein; Region: OpgC_C; pfam10129 266265015606 Tannase and feruloyl esterase; Region: Tannase; pfam07519 266265015607 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 266265015608 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 266265015609 Walker A/P-loop; other site 266265015610 ATP binding site [chemical binding]; other site 266265015611 Q-loop/lid; other site 266265015612 ABC transporter signature motif; other site 266265015613 Walker B; other site 266265015614 D-loop; other site 266265015615 H-loop/switch region; other site 266265015616 ABC-2 type transporter; Region: ABC2_membrane; cl17235 266265015617 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 266265015618 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266265015619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265015620 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265015621 DNA binding residues [nucleotide binding] 266265015622 dimerization interface [polypeptide binding]; other site 266265015623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265015624 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265015625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265015626 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 266265015627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265015628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 266265015629 dimer interface [polypeptide binding]; other site 266265015630 phosphorylation site [posttranslational modification] 266265015631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265015632 ATP binding site [chemical binding]; other site 266265015633 Mg2+ binding site [ion binding]; other site 266265015634 G-X-G motif; other site 266265015635 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 266265015636 YadA-like C-terminal region; Region: YadA; pfam03895 266265015637 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266265015638 shikimate transporter; Provisional; Region: PRK09952 266265015639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015640 putative substrate translocation pore; other site 266265015641 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265015642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265015643 DNA-binding site [nucleotide binding]; DNA binding site 266265015644 FCD domain; Region: FCD; pfam07729 266265015645 formyl-coenzyme A transferase; Provisional; Region: PRK05398 266265015646 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265015647 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265015648 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265015649 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 266265015650 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265015651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015652 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 266265015653 putative dimerization interface [polypeptide binding]; other site 266265015654 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 266265015655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015656 putative substrate translocation pore; other site 266265015657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265015658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015659 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266265015660 putative dimerization interface [polypeptide binding]; other site 266265015661 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265015662 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 266265015663 NAD(P) binding site [chemical binding]; other site 266265015664 catalytic residues [active] 266265015665 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 266265015666 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266265015667 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266265015668 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266265015669 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266265015670 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266265015671 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 266265015672 SLBB domain; Region: SLBB; pfam10531 266265015673 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266265015674 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266265015675 active site 266265015676 tyrosine kinase; Provisional; Region: PRK11519 266265015677 Chain length determinant protein; Region: Wzz; pfam02706 266265015678 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266265015679 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265015680 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 266265015681 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266265015682 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 266265015683 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266265015684 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 266265015685 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 266265015686 Glycosyltransferase involved in LPS biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG3306 266265015687 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 266265015688 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265015689 putative ADP-binding pocket [chemical binding]; other site 266265015690 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 266265015691 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 266265015692 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 266265015693 putative acyl transferase; Provisional; Region: PRK10191 266265015694 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266265015695 trimer interface [polypeptide binding]; other site 266265015696 active site 266265015697 substrate binding site [chemical binding]; other site 266265015698 CoA binding site [chemical binding]; other site 266265015699 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265015700 Uncharacterized conserved protein [Function unknown]; Region: COG1739 266265015701 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 266265015702 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 266265015703 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265015704 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 266265015705 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 266265015706 putative catalytic residue [active] 266265015707 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 266265015708 Protein of unknown function, DUF484; Region: DUF484; cl17449 266265015709 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265015710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265015711 metal binding site [ion binding]; metal-binding site 266265015712 active site 266265015713 I-site; other site 266265015714 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 266265015715 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 266265015716 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 266265015717 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 266265015718 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 266265015719 HAMP domain; Region: HAMP; pfam00672 266265015720 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265015721 dimer interface [polypeptide binding]; other site 266265015722 putative CheW interface [polypeptide binding]; other site 266265015723 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266265015724 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266265015725 tetramer interface [polypeptide binding]; other site 266265015726 active site 266265015727 Mg2+/Mn2+ binding site [ion binding]; other site 266265015728 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266265015729 active site 266265015730 metal-binding site 266265015731 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265015732 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 266265015733 PYR/PP interface [polypeptide binding]; other site 266265015734 dimer interface [polypeptide binding]; other site 266265015735 TPP binding site [chemical binding]; other site 266265015736 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 266265015737 TPP-binding site; other site 266265015738 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266265015739 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265015740 catalytic residue [active] 266265015741 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 266265015742 HipA N-terminal domain; Region: Couple_hipA; cl11853 266265015743 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266265015744 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266265015745 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 266265015746 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266265015747 Fe-S cluster binding site [ion binding]; other site 266265015748 active site 266265015749 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 266265015750 Ligand binding site; other site 266265015751 metal-binding site 266265015752 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265015753 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265015754 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265015755 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265015756 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266265015757 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265015758 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265015759 catalytic loop [active] 266265015760 iron binding site [ion binding]; other site 266265015761 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265015762 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 266265015763 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 266265015764 putative catalytic site [active] 266265015765 putative phosphate binding site [ion binding]; other site 266265015766 active site 266265015767 metal binding site A [ion binding]; metal-binding site 266265015768 DNA binding site [nucleotide binding] 266265015769 putative AP binding site [nucleotide binding]; other site 266265015770 putative metal binding site B [ion binding]; other site 266265015771 CsbD-like; Region: CsbD; pfam05532 266265015772 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 266265015773 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 266265015774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 266265015775 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 266265015776 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 266265015777 NodB motif; other site 266265015778 active site 266265015779 catalytic site [active] 266265015780 metal binding site [ion binding]; metal-binding site 266265015781 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266265015782 classical (c) SDRs; Region: SDR_c; cd05233 266265015783 NAD(P) binding site [chemical binding]; other site 266265015784 active site 266265015785 NAD-dependent deacetylase; Provisional; Region: PRK05333 266265015786 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 266265015787 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 266265015788 Protein of unknown function (DUF938); Region: DUF938; pfam06080 266265015789 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265015790 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 266265015791 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 266265015792 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265015793 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 266265015794 Cupin domain; Region: Cupin_2; cl17218 266265015795 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266265015796 Peptidase family M23; Region: Peptidase_M23; pfam01551 266265015797 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 266265015798 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 266265015799 tetramer interface [polypeptide binding]; other site 266265015800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265015801 catalytic residue [active] 266265015802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265015804 Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375 266265015805 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 266265015806 homodimer interface [polypeptide binding]; other site 266265015807 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 266265015808 active site pocket [active] 266265015809 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 266265015810 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 266265015811 putative hydrolase; Provisional; Region: PRK11460 266265015812 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265015813 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265015814 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 266265015815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265015816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265015817 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265015818 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265015819 trimer interface [polypeptide binding]; other site 266265015820 eyelet of channel; other site 266265015821 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266265015822 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266265015823 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 266265015824 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 266265015825 active site 266265015826 Zn binding site [ion binding]; other site 266265015827 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 266265015828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265015829 substrate binding pocket [chemical binding]; other site 266265015830 membrane-bound complex binding site; other site 266265015831 hinge residues; other site 266265015832 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265015833 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266265015834 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265015835 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265015836 metal binding site [ion binding]; metal-binding site 266265015837 active site 266265015838 I-site; other site 266265015839 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 266265015840 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265015841 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 266265015842 active site 266265015843 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 266265015844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265015845 Walker A/P-loop; other site 266265015846 ATP binding site [chemical binding]; other site 266265015847 Q-loop/lid; other site 266265015848 ABC transporter signature motif; other site 266265015849 Walker B; other site 266265015850 D-loop; other site 266265015851 H-loop/switch region; other site 266265015852 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 266265015853 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265015854 Walker A/P-loop; other site 266265015855 ATP binding site [chemical binding]; other site 266265015856 Q-loop/lid; other site 266265015857 ABC transporter signature motif; other site 266265015858 Walker B; other site 266265015859 D-loop; other site 266265015860 H-loop/switch region; other site 266265015861 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265015862 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 266265015863 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 266265015864 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 266265015865 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 266265015866 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 266265015867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265015868 DNA-binding site [nucleotide binding]; DNA binding site 266265015869 UTRA domain; Region: UTRA; pfam07702 266265015870 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 266265015871 Guanylate kinase; Region: Guanylate_kin; pfam00625 266265015872 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 266265015873 active site 266265015874 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266265015875 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266265015876 metal binding site [ion binding]; metal-binding site 266265015877 putative dimer interface [polypeptide binding]; other site 266265015878 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 266265015879 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265015880 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265015881 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265015882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265015883 DNA-binding site [nucleotide binding]; DNA binding site 266265015884 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266265015885 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265015886 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265015887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 266265015888 putative aldolase; Validated; Region: PRK08130 266265015889 intersubunit interface [polypeptide binding]; other site 266265015890 active site 266265015891 Zn2+ binding site [ion binding]; other site 266265015892 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 266265015893 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265015894 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 266265015895 putative NAD(P) binding site [chemical binding]; other site 266265015896 active site 266265015897 putative substrate binding site [chemical binding]; other site 266265015898 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 266265015899 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265015900 dimer interface [polypeptide binding]; other site 266265015901 active site 266265015902 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 266265015903 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266265015904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265015905 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265015906 Serine hydrolase; Region: Ser_hydrolase; cl17834 266265015907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015908 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266265015909 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 266265015910 putative dimerization interface [polypeptide binding]; other site 266265015911 putative substrate binding pocket [chemical binding]; other site 266265015912 D-lactate dehydrogenase; Provisional; Region: PRK11183 266265015913 FAD binding domain; Region: FAD_binding_4; pfam01565 266265015914 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 266265015915 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265015916 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265015917 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 266265015918 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265015919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265015920 NAD(P) binding site [chemical binding]; other site 266265015921 active site 266265015922 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265015923 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265015924 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266265015925 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265015926 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 266265015927 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265015928 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265015929 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265015930 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 266265015931 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265015932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015933 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265015934 dimerization interface [polypeptide binding]; other site 266265015935 substrate binding pocket [chemical binding]; other site 266265015936 NHL repeat; Region: NHL; pfam01436 266265015937 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265015938 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265015939 NAD(P) binding site [chemical binding]; other site 266265015940 catalytic residues [active] 266265015941 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265015942 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266265015943 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266265015944 tetramer interface [polypeptide binding]; other site 266265015945 active site 266265015946 Mg2+/Mn2+ binding site [ion binding]; other site 266265015947 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266265015948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266265015949 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265015950 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265015951 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266265015952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015953 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 266265015954 putative dimerization interface [polypeptide binding]; other site 266265015955 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265015956 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 266265015957 active site 266265015958 iron coordination sites [ion binding]; other site 266265015959 substrate binding pocket [chemical binding]; other site 266265015960 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265015961 Strictosidine synthase; Region: Str_synth; pfam03088 266265015962 short chain dehydrogenase; Provisional; Region: PRK06180 266265015963 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265015964 NADP binding site [chemical binding]; other site 266265015965 active site 266265015966 steroid binding site; other site 266265015967 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265015968 NHL repeat; Region: NHL; pfam01436 266265015969 NHL repeat; Region: NHL; pfam01436 266265015970 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265015971 NHL repeat; Region: NHL; pfam01436 266265015972 NIPSNAP; Region: NIPSNAP; pfam07978 266265015973 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265015974 NIPSNAP; Region: NIPSNAP; pfam07978 266265015975 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265015976 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265015977 trimer interface [polypeptide binding]; other site 266265015978 eyelet of channel; other site 266265015979 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265015980 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265015981 Amino acid synthesis; Region: AA_synth; pfam06684 266265015982 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266265015983 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266265015984 putative ligand binding site [chemical binding]; other site 266265015985 NAD binding site [chemical binding]; other site 266265015986 catalytic site [active] 266265015987 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265015988 FAD binding domain; Region: FAD_binding_4; pfam01565 266265015989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265015990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265015991 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266265015992 putative dimerization interface [polypeptide binding]; other site 266265015993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266265015994 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265015995 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266265015996 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266265015997 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265015998 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265015999 ligand binding site [chemical binding]; other site 266265016000 flexible hinge region; other site 266265016001 Outer membrane efflux protein; Region: OEP; pfam02321 266265016002 Outer membrane efflux protein; Region: OEP; pfam02321 266265016003 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266265016004 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265016005 multidrug resistance protein MdtN; Provisional; Region: PRK10476 266265016006 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265016007 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265016008 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 266265016009 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 266265016010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265016011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265016012 ATP binding site [chemical binding]; other site 266265016013 Mg2+ binding site [ion binding]; other site 266265016014 G-X-G motif; other site 266265016015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265016016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265016018 dimerization interface [polypeptide binding]; other site 266265016019 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265016020 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265016021 active site 266265016022 catalytic tetrad [active] 266265016023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265016024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016025 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 266265016026 putative substrate binding pocket [chemical binding]; other site 266265016027 putative dimerization interface [polypeptide binding]; other site 266265016028 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 266265016029 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265016030 Predicted esterase [General function prediction only]; Region: COG0627 266265016031 aspartate carbamoyltransferase; Provisional; Region: PRK11891 266265016032 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266265016033 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266265016034 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266265016035 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266265016036 dimer interface [polypeptide binding]; other site 266265016037 active site 266265016038 catalytic residue [active] 266265016039 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266265016040 Peptidase family M23; Region: Peptidase_M23; pfam01551 266265016041 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 266265016042 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 266265016043 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266265016044 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 266265016045 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265016046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265016047 metal binding site [ion binding]; metal-binding site 266265016048 active site 266265016049 I-site; other site 266265016050 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265016051 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265016052 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266265016053 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266265016054 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 266265016055 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 266265016056 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266265016057 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 266265016058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265016059 motif II; other site 266265016060 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 266265016061 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 266265016062 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 266265016063 FOG: CBS domain [General function prediction only]; Region: COG0517 266265016064 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 266265016065 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016066 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 266265016067 putative dimerization interface [polypeptide binding]; other site 266265016068 SnoaL-like domain; Region: SnoaL_3; pfam13474 266265016069 SnoaL-like domain; Region: SnoaL_2; pfam12680 266265016070 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266265016071 active site 266265016072 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 266265016073 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 266265016074 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 266265016075 active site residue [active] 266265016076 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 266265016077 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266265016078 conserved cys residue [active] 266265016079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 266265016080 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 266265016081 beta-galactosidase; Region: BGL; TIGR03356 266265016082 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 266265016083 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266265016084 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266265016085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016086 dimer interface [polypeptide binding]; other site 266265016087 conserved gate region; other site 266265016088 putative PBP binding loops; other site 266265016089 ABC-ATPase subunit interface; other site 266265016090 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266265016091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016092 dimer interface [polypeptide binding]; other site 266265016093 conserved gate region; other site 266265016094 putative PBP binding loops; other site 266265016095 ABC-ATPase subunit interface; other site 266265016096 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266265016097 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266265016098 Walker A/P-loop; other site 266265016099 ATP binding site [chemical binding]; other site 266265016100 Q-loop/lid; other site 266265016101 ABC transporter signature motif; other site 266265016102 Walker B; other site 266265016103 D-loop; other site 266265016104 H-loop/switch region; other site 266265016105 TOBE domain; Region: TOBE_2; pfam08402 266265016106 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265016107 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265016108 DNA binding site [nucleotide binding] 266265016109 domain linker motif; other site 266265016110 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 266265016111 dimerization interface (closed form) [polypeptide binding]; other site 266265016112 ligand binding site [chemical binding]; other site 266265016113 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 266265016114 ATP binding site [chemical binding]; other site 266265016115 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 266265016116 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 266265016117 Sulfate transporter family; Region: Sulfate_transp; pfam00916 266265016118 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 266265016119 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265016120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265016121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016122 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 266265016123 putative dimerization interface [polypeptide binding]; other site 266265016124 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 266265016125 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265016126 putative metal binding site [ion binding]; other site 266265016127 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266265016128 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265016129 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265016130 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265016131 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266265016132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265016133 active site 266265016134 phosphorylation site [posttranslational modification] 266265016135 intermolecular recognition site; other site 266265016136 dimerization interface [polypeptide binding]; other site 266265016137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265016138 DNA binding site [nucleotide binding] 266265016139 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266265016140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265016141 dimer interface [polypeptide binding]; other site 266265016142 phosphorylation site [posttranslational modification] 266265016143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265016144 ATP binding site [chemical binding]; other site 266265016145 Mg2+ binding site [ion binding]; other site 266265016146 G-X-G motif; other site 266265016147 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 266265016148 active site 266265016149 DNA polymerase IV; Validated; Region: PRK02406 266265016150 DNA binding site [nucleotide binding] 266265016151 Uncharacterized conserved protein [Function unknown]; Region: COG2353 266265016152 YceI-like domain; Region: YceI; smart00867 266265016153 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266265016154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265016155 PAS fold; Region: PAS_3; pfam08447 266265016156 putative active site [active] 266265016157 heme pocket [chemical binding]; other site 266265016158 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265016159 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265016160 metal binding site [ion binding]; metal-binding site 266265016161 active site 266265016162 I-site; other site 266265016163 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 266265016164 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 266265016165 transmembrane helices; other site 266265016166 osmolarity response regulator; Provisional; Region: ompR; PRK09468 266265016167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265016168 active site 266265016169 phosphorylation site [posttranslational modification] 266265016170 intermolecular recognition site; other site 266265016171 dimerization interface [polypeptide binding]; other site 266265016172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265016173 DNA binding site [nucleotide binding] 266265016174 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 266265016175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265016176 dimerization interface [polypeptide binding]; other site 266265016177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265016178 dimer interface [polypeptide binding]; other site 266265016179 phosphorylation site [posttranslational modification] 266265016180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265016181 ATP binding site [chemical binding]; other site 266265016182 Mg2+ binding site [ion binding]; other site 266265016183 G-X-G motif; other site 266265016184 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 266265016185 active site 266265016186 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 266265016187 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 266265016188 putative active site [active] 266265016189 putative NTP binding site [chemical binding]; other site 266265016190 putative nucleic acid binding site [nucleotide binding]; other site 266265016191 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266265016192 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265016193 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265016194 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265016195 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265016196 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265016197 substrate binding pocket [chemical binding]; other site 266265016198 membrane-bound complex binding site; other site 266265016199 hinge residues; other site 266265016200 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265016201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016202 dimer interface [polypeptide binding]; other site 266265016203 conserved gate region; other site 266265016204 putative PBP binding loops; other site 266265016205 ABC-ATPase subunit interface; other site 266265016206 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 266265016207 putative active site [active] 266265016208 putative metal binding site [ion binding]; other site 266265016209 Protein of unknown function DUF72; Region: DUF72; pfam01904 266265016210 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 266265016211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 266265016212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265016213 binding surface 266265016214 TPR motif; other site 266265016215 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 266265016216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265016217 TPR motif; other site 266265016218 binding surface 266265016219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265016220 TPR motif; other site 266265016221 binding surface 266265016222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265016223 TPR motif; other site 266265016224 binding surface 266265016225 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 266265016226 endo-1,4-D-glucanase; Provisional; Region: PRK11097 266265016227 cellulose synthase regulator protein; Provisional; Region: PRK11114 266265016228 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 266265016229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266265016230 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 266265016231 DXD motif; other site 266265016232 PilZ domain; Region: PilZ; pfam07238 266265016233 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 266265016234 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265016235 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 266265016236 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265016237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265016238 metal binding site [ion binding]; metal-binding site 266265016239 active site 266265016240 I-site; other site 266265016241 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265016242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265016243 metal binding site [ion binding]; metal-binding site 266265016244 active site 266265016245 I-site; other site 266265016246 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265016247 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266265016248 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265016249 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 266265016250 putative substrate binding pocket [chemical binding]; other site 266265016251 trimer interface [polypeptide binding]; other site 266265016252 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 266265016253 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 266265016254 putative active site [active] 266265016255 putative metal binding site [ion binding]; other site 266265016256 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 266265016257 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 266265016258 NAD binding site [chemical binding]; other site 266265016259 catalytic residues [active] 266265016260 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 266265016261 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265016262 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265016263 MarR family; Region: MarR_2; cl17246 266265016264 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265016265 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 266265016266 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 266265016267 dimer interface [polypeptide binding]; other site 266265016268 active site 266265016269 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266265016270 substrate binding site [chemical binding]; other site 266265016271 catalytic residue [active] 266265016272 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266265016273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265016274 motif II; other site 266265016275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265016276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016277 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 266265016278 putative effector binding pocket; other site 266265016279 putative dimerization interface [polypeptide binding]; other site 266265016280 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266265016281 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266265016282 tetrameric interface [polypeptide binding]; other site 266265016283 NAD binding site [chemical binding]; other site 266265016284 catalytic residues [active] 266265016285 H+ Antiporter protein; Region: 2A0121; TIGR00900 266265016286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016287 putative substrate translocation pore; other site 266265016288 Isochorismatase family; Region: Isochorismatase; pfam00857 266265016289 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266265016290 catalytic triad [active] 266265016291 conserved cis-peptide bond; other site 266265016292 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265016293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265016294 putative DNA binding site [nucleotide binding]; other site 266265016295 putative Zn2+ binding site [ion binding]; other site 266265016296 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266265016297 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266265016298 Coenzyme A binding pocket [chemical binding]; other site 266265016299 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266265016300 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266265016301 FMN binding site [chemical binding]; other site 266265016302 active site 266265016303 substrate binding site [chemical binding]; other site 266265016304 catalytic residue [active] 266265016305 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265016306 putative DNA binding site [nucleotide binding]; other site 266265016307 dimerization interface [polypeptide binding]; other site 266265016308 putative Zn2+ binding site [ion binding]; other site 266265016309 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265016310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 266265016311 DNA-binding site [nucleotide binding]; DNA binding site 266265016312 FCD domain; Region: FCD; pfam07729 266265016313 GAF domain; Region: GAF; cl17456 266265016314 GAF domain; Region: GAF_2; pfam13185 266265016315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265016316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265016317 dimer interface [polypeptide binding]; other site 266265016318 phosphorylation site [posttranslational modification] 266265016319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265016320 ATP binding site [chemical binding]; other site 266265016321 Mg2+ binding site [ion binding]; other site 266265016322 G-X-G motif; other site 266265016323 Response regulator receiver domain; Region: Response_reg; pfam00072 266265016324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265016325 active site 266265016326 phosphorylation site [posttranslational modification] 266265016327 intermolecular recognition site; other site 266265016328 dimerization interface [polypeptide binding]; other site 266265016329 Low affinity iron permease; Region: Iron_permease; pfam04120 266265016330 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265016331 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 266265016332 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 266265016333 Protein export membrane protein; Region: SecD_SecF; cl14618 266265016334 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265016335 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265016336 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265016337 Response regulator receiver domain; Region: Response_reg; pfam00072 266265016338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265016339 active site 266265016340 phosphorylation site [posttranslational modification] 266265016341 intermolecular recognition site; other site 266265016342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265016343 dimerization interface [polypeptide binding]; other site 266265016344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265016345 dimer interface [polypeptide binding]; other site 266265016346 phosphorylation site [posttranslational modification] 266265016347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265016348 ATP binding site [chemical binding]; other site 266265016349 G-X-G motif; other site 266265016350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265016351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265016352 ATP binding site [chemical binding]; other site 266265016353 Mg2+ binding site [ion binding]; other site 266265016354 G-X-G motif; other site 266265016355 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265016356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265016357 active site 266265016358 phosphorylation site [posttranslational modification] 266265016359 intermolecular recognition site; other site 266265016360 dimerization interface [polypeptide binding]; other site 266265016361 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265016362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265016363 active site 266265016364 phosphorylation site [posttranslational modification] 266265016365 intermolecular recognition site; other site 266265016366 dimerization interface [polypeptide binding]; other site 266265016367 hydroxymethylglutaryl-CoA synthase; Region: PLN02577 266265016368 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 266265016369 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266265016370 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 266265016371 active site 266265016372 LssY C-terminus; Region: LssY_C; pfam14067 266265016373 OsmC-like protein; Region: OsmC; cl00767 266265016374 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265016375 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265016376 putative DNA binding site [nucleotide binding]; other site 266265016377 putative Zn2+ binding site [ion binding]; other site 266265016378 AsnC family; Region: AsnC_trans_reg; pfam01037 266265016379 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265016380 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 266265016381 hypothetical protein; Provisional; Region: PRK02237 266265016382 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 266265016383 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 266265016384 peptidase domain interface [polypeptide binding]; other site 266265016385 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 266265016386 active site 266265016387 catalytic triad [active] 266265016388 calcium binding site [ion binding]; other site 266265016389 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 266265016390 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 266265016391 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266265016392 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 266265016393 homodimer interface [polypeptide binding]; other site 266265016394 NAD binding pocket [chemical binding]; other site 266265016395 ATP binding pocket [chemical binding]; other site 266265016396 Mg binding site [ion binding]; other site 266265016397 active-site loop [active] 266265016398 ABC1 family; Region: ABC1; cl17513 266265016399 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 266265016400 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266265016401 putative ligand binding site [chemical binding]; other site 266265016402 NAD binding site [chemical binding]; other site 266265016403 dimerization interface [polypeptide binding]; other site 266265016404 catalytic site [active] 266265016405 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 266265016406 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265016407 inhibitor-cofactor binding pocket; inhibition site 266265016408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265016409 catalytic residue [active] 266265016410 aldolase II superfamily protein; Provisional; Region: PRK07044 266265016411 intersubunit interface [polypeptide binding]; other site 266265016412 active site 266265016413 Zn2+ binding site [ion binding]; other site 266265016414 succinic semialdehyde dehydrogenase; Region: PLN02278 266265016415 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266265016416 tetramerization interface [polypeptide binding]; other site 266265016417 NAD(P) binding site [chemical binding]; other site 266265016418 catalytic residues [active] 266265016419 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266265016420 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265016421 Walker A/P-loop; other site 266265016422 ATP binding site [chemical binding]; other site 266265016423 Q-loop/lid; other site 266265016424 ABC transporter signature motif; other site 266265016425 Walker B; other site 266265016426 D-loop; other site 266265016427 H-loop/switch region; other site 266265016428 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265016429 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266265016430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265016431 Walker A/P-loop; other site 266265016432 ATP binding site [chemical binding]; other site 266265016433 Q-loop/lid; other site 266265016434 ABC transporter signature motif; other site 266265016435 Walker B; other site 266265016436 D-loop; other site 266265016437 H-loop/switch region; other site 266265016438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265016439 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266265016440 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266265016441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016442 putative PBP binding loops; other site 266265016443 ABC-ATPase subunit interface; other site 266265016444 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266265016445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016446 dimer interface [polypeptide binding]; other site 266265016447 conserved gate region; other site 266265016448 putative PBP binding loops; other site 266265016449 ABC-ATPase subunit interface; other site 266265016450 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265016451 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266265016452 NAD(P) binding site [chemical binding]; other site 266265016453 catalytic residues [active] 266265016454 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265016455 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265016456 active site 266265016457 catalytic tetrad [active] 266265016458 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266265016459 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265016460 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265016461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265016462 DNA-binding site [nucleotide binding]; DNA binding site 266265016463 FCD domain; Region: FCD; pfam07729 266265016464 Amino acid synthesis; Region: AA_synth; pfam06684 266265016465 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266265016466 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265016467 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265016468 trimer interface [polypeptide binding]; other site 266265016469 eyelet of channel; other site 266265016470 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265016471 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 266265016472 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 266265016473 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265016474 catalytic site [active] 266265016475 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 266265016476 NADH(P)-binding; Region: NAD_binding_10; pfam13460 266265016477 NAD(P) binding site [chemical binding]; other site 266265016478 putative active site [active] 266265016479 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266265016480 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266265016481 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265016482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016483 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266265016484 putative effector binding pocket; other site 266265016485 putative dimerization interface [polypeptide binding]; other site 266265016486 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265016487 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265016488 active site 266265016489 catalytic tetrad [active] 266265016490 short chain dehydrogenase; Provisional; Region: PRK06180 266265016491 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265016492 NADP binding site [chemical binding]; other site 266265016493 active site 266265016494 steroid binding site; other site 266265016495 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265016496 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265016497 active site 266265016498 catalytic tetrad [active] 266265016499 transposase; Validated; Region: PRK08181 266265016500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265016501 Walker A motif; other site 266265016502 ATP binding site [chemical binding]; other site 266265016503 Integrase core domain; Region: rve; pfam00665 266265016504 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265016505 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266265016506 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265016507 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265016508 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265016509 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266265016510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265016511 active site 266265016512 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266265016513 benzoate transport; Region: 2A0115; TIGR00895 266265016514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016515 putative substrate translocation pore; other site 266265016516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016517 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265016518 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265016519 trimer interface [polypeptide binding]; other site 266265016520 eyelet of channel; other site 266265016521 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 266265016522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265016523 NAD(P) binding site [chemical binding]; other site 266265016524 active site 266265016525 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266265016526 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265016527 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266265016528 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 266265016529 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266265016530 Walker A/P-loop; other site 266265016531 ATP binding site [chemical binding]; other site 266265016532 Q-loop/lid; other site 266265016533 ABC transporter signature motif; other site 266265016534 Walker B; other site 266265016535 D-loop; other site 266265016536 H-loop/switch region; other site 266265016537 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 266265016538 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266265016539 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 266265016540 Walker A/P-loop; other site 266265016541 ATP binding site [chemical binding]; other site 266265016542 Q-loop/lid; other site 266265016543 ABC transporter signature motif; other site 266265016544 Walker B; other site 266265016545 D-loop; other site 266265016546 H-loop/switch region; other site 266265016547 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 266265016548 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 266265016549 folate binding site [chemical binding]; other site 266265016550 NADP+ binding site [chemical binding]; other site 266265016551 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266265016552 GAF domain; Region: GAF; pfam01590 266265016553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265016554 PAS domain; Region: PAS_9; pfam13426 266265016555 putative active site [active] 266265016556 heme pocket [chemical binding]; other site 266265016557 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265016558 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265016559 metal binding site [ion binding]; metal-binding site 266265016560 active site 266265016561 I-site; other site 266265016562 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265016563 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 266265016564 citrate-proton symporter; Provisional; Region: PRK15075 266265016565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016566 putative substrate translocation pore; other site 266265016567 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 266265016568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265016569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265016571 dimerization interface [polypeptide binding]; other site 266265016572 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265016573 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265016574 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265016575 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266265016576 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266265016577 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266265016578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266265016579 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265016580 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 266265016581 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 266265016582 tetramer interface [polypeptide binding]; other site 266265016583 active site 266265016584 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266265016585 CoA binding domain; Region: CoA_binding_2; pfam13380 266265016586 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266265016587 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266265016588 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265016589 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266265016590 CoA binding domain; Region: CoA_binding_2; pfam13380 266265016591 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266265016592 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266265016593 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265016594 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 266265016595 substrate binding site [chemical binding]; other site 266265016596 oxyanion hole (OAH) forming residues; other site 266265016597 trimer interface [polypeptide binding]; other site 266265016598 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265016599 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265016600 active site 266265016601 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265016602 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265016603 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265016604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016605 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 266265016606 putative dimerization interface [polypeptide binding]; other site 266265016607 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 266265016608 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265016609 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266265016610 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266265016611 active site pocket [active] 266265016612 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266265016613 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 266265016614 ligand binding site [chemical binding]; other site 266265016615 NAD binding site [chemical binding]; other site 266265016616 dimerization interface [polypeptide binding]; other site 266265016617 catalytic site [active] 266265016618 enoyl-CoA hydratase; Provisional; Region: PRK08252 266265016619 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265016620 substrate binding site [chemical binding]; other site 266265016621 oxyanion hole (OAH) forming residues; other site 266265016622 trimer interface [polypeptide binding]; other site 266265016623 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265016624 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265016625 acyl-activating enzyme (AAE) consensus motif; other site 266265016626 AMP binding site [chemical binding]; other site 266265016627 active site 266265016628 CoA binding site [chemical binding]; other site 266265016629 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 266265016630 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 266265016631 NADP binding site [chemical binding]; other site 266265016632 dimer interface [polypeptide binding]; other site 266265016633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265016634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265016636 dimerization interface [polypeptide binding]; other site 266265016637 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 266265016638 active site 266265016639 iron coordination sites [ion binding]; other site 266265016640 substrate binding pocket [chemical binding]; other site 266265016641 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265016642 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265016643 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265016644 acyl-activating enzyme (AAE) consensus motif; other site 266265016645 acyl-activating enzyme (AAE) consensus motif; other site 266265016646 AMP binding site [chemical binding]; other site 266265016647 active site 266265016648 CoA binding site [chemical binding]; other site 266265016649 Coenzyme A transferase; Region: CoA_trans; cl17247 266265016650 Coenzyme A transferase; Region: CoA_trans; smart00882 266265016651 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265016652 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265016653 substrate binding site [chemical binding]; other site 266265016654 oxyanion hole (OAH) forming residues; other site 266265016655 trimer interface [polypeptide binding]; other site 266265016656 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265016657 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265016658 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265016659 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265016660 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265016661 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 266265016662 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 266265016663 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 266265016664 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266265016665 oligomeric interface; other site 266265016666 putative active site [active] 266265016667 homodimer interface [polypeptide binding]; other site 266265016668 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266265016669 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266265016670 active site 266265016671 DNA binding site [nucleotide binding] 266265016672 Int/Topo IB signature motif; other site 266265016673 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266265016674 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266265016675 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266265016676 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 266265016677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265016678 catalytic residue [active] 266265016679 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265016680 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265016681 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 266265016682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265016683 Walker A/P-loop; other site 266265016684 ATP binding site [chemical binding]; other site 266265016685 Q-loop/lid; other site 266265016686 ABC transporter signature motif; other site 266265016687 Walker B; other site 266265016688 D-loop; other site 266265016689 H-loop/switch region; other site 266265016690 TOBE domain; Region: TOBE_2; pfam08402 266265016691 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 266265016692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016693 dimer interface [polypeptide binding]; other site 266265016694 conserved gate region; other site 266265016695 putative PBP binding loops; other site 266265016696 ABC-ATPase subunit interface; other site 266265016697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016698 dimer interface [polypeptide binding]; other site 266265016699 conserved gate region; other site 266265016700 ABC-ATPase subunit interface; other site 266265016701 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 266265016702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265016703 DNA-binding site [nucleotide binding]; DNA binding site 266265016704 FCD domain; Region: FCD; pfam07729 266265016705 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 266265016706 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 266265016707 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 266265016708 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 266265016709 NAD(P) binding site [chemical binding]; other site 266265016710 catalytic residues [active] 266265016711 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 266265016712 Zn2+ binding site [ion binding]; other site 266265016713 Mg2+ binding site [ion binding]; other site 266265016714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265016715 Transposase; Region: HTH_Tnp_1; pfam01527 266265016716 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265016717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265016718 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 266265016719 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265016720 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265016721 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265016722 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265016723 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265016724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016725 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265016726 putative effector binding pocket; other site 266265016727 dimerization interface [polypeptide binding]; other site 266265016728 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266265016729 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 266265016730 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 266265016731 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 266265016732 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 266265016733 MgtC family; Region: MgtC; pfam02308 266265016734 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 266265016735 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266265016736 putative active site [active] 266265016737 putative metal binding site [ion binding]; other site 266265016738 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 266265016739 putative FMN binding site [chemical binding]; other site 266265016740 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 266265016741 Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375 266265016742 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 266265016743 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 266265016744 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 266265016745 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 266265016746 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 266265016747 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 266265016748 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 266265016749 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 266265016750 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 266265016751 Coenzyme A transferase; Region: CoA_trans; cl17247 266265016752 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 266265016753 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265016754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265016755 DNA-binding site [nucleotide binding]; DNA binding site 266265016756 FCD domain; Region: FCD; pfam07729 266265016757 benzoate transport; Region: 2A0115; TIGR00895 266265016758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016759 putative substrate translocation pore; other site 266265016760 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 266265016761 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 266265016762 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 266265016763 EamA-like transporter family; Region: EamA; pfam00892 266265016764 EamA-like transporter family; Region: EamA; pfam00892 266265016765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265016766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265016767 dimerization interface [polypeptide binding]; other site 266265016768 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265016769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265016770 Walker A/P-loop; other site 266265016771 ATP binding site [chemical binding]; other site 266265016772 Q-loop/lid; other site 266265016773 ABC transporter signature motif; other site 266265016774 Walker B; other site 266265016775 D-loop; other site 266265016776 H-loop/switch region; other site 266265016777 TOBE domain; Region: TOBE_2; pfam08402 266265016778 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266265016779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016780 dimer interface [polypeptide binding]; other site 266265016781 conserved gate region; other site 266265016782 ABC-ATPase subunit interface; other site 266265016783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016784 dimer interface [polypeptide binding]; other site 266265016785 conserved gate region; other site 266265016786 putative PBP binding loops; other site 266265016787 ABC-ATPase subunit interface; other site 266265016788 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266265016789 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265016790 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 266265016791 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 266265016792 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 266265016793 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 266265016794 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 266265016795 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 266265016796 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265016797 substrate binding pocket [chemical binding]; other site 266265016798 membrane-bound complex binding site; other site 266265016799 hinge residues; other site 266265016800 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265016801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016802 dimer interface [polypeptide binding]; other site 266265016803 conserved gate region; other site 266265016804 putative PBP binding loops; other site 266265016805 ABC-ATPase subunit interface; other site 266265016806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016807 dimer interface [polypeptide binding]; other site 266265016808 conserved gate region; other site 266265016809 putative PBP binding loops; other site 266265016810 ABC-ATPase subunit interface; other site 266265016811 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 266265016812 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265016813 Walker A/P-loop; other site 266265016814 ATP binding site [chemical binding]; other site 266265016815 Q-loop/lid; other site 266265016816 ABC transporter signature motif; other site 266265016817 Walker B; other site 266265016818 D-loop; other site 266265016819 H-loop/switch region; other site 266265016820 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266265016821 active sites [active] 266265016822 tetramer interface [polypeptide binding]; other site 266265016823 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266265016824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265016825 DNA-binding site [nucleotide binding]; DNA binding site 266265016826 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 266265016827 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266265016828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265016829 DNA-binding site [nucleotide binding]; DNA binding site 266265016830 UTRA domain; Region: UTRA; pfam07702 266265016831 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265016832 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265016833 Walker A/P-loop; other site 266265016834 ATP binding site [chemical binding]; other site 266265016835 Q-loop/lid; other site 266265016836 ABC transporter signature motif; other site 266265016837 Walker B; other site 266265016838 D-loop; other site 266265016839 H-loop/switch region; other site 266265016840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016841 dimer interface [polypeptide binding]; other site 266265016842 conserved gate region; other site 266265016843 putative PBP binding loops; other site 266265016844 ABC-ATPase subunit interface; other site 266265016845 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265016846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265016847 dimer interface [polypeptide binding]; other site 266265016848 conserved gate region; other site 266265016849 putative PBP binding loops; other site 266265016850 ABC-ATPase subunit interface; other site 266265016851 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265016852 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265016853 substrate binding pocket [chemical binding]; other site 266265016854 membrane-bound complex binding site; other site 266265016855 hinge residues; other site 266265016856 oxidase reductase; Provisional; Region: PTZ00273 266265016857 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 266265016858 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 266265016859 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265016860 FAD binding domain; Region: FAD_binding_4; pfam01565 266265016861 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266265016862 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265016863 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 266265016864 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266265016865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265016866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265016867 dimer interface [polypeptide binding]; other site 266265016868 phosphorylation site [posttranslational modification] 266265016869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265016870 ATP binding site [chemical binding]; other site 266265016871 Mg2+ binding site [ion binding]; other site 266265016872 G-X-G motif; other site 266265016873 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265016874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265016875 active site 266265016876 phosphorylation site [posttranslational modification] 266265016877 intermolecular recognition site; other site 266265016878 dimerization interface [polypeptide binding]; other site 266265016879 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265016880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265016881 active site 266265016882 phosphorylation site [posttranslational modification] 266265016883 intermolecular recognition site; other site 266265016884 dimerization interface [polypeptide binding]; other site 266265016885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265016886 DNA binding residues [nucleotide binding] 266265016887 dimerization interface [polypeptide binding]; other site 266265016888 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 266265016889 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 266265016890 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 266265016891 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265016892 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265016893 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265016894 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 266265016895 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 266265016896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265016897 NAD(P) binding site [chemical binding]; other site 266265016898 active site 266265016899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016900 D-galactonate transporter; Region: 2A0114; TIGR00893 266265016901 putative substrate translocation pore; other site 266265016902 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266265016903 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 266265016904 dimer interface [polypeptide binding]; other site 266265016905 NADP binding site [chemical binding]; other site 266265016906 catalytic residues [active] 266265016907 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265016908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265016909 DNA-binding site [nucleotide binding]; DNA binding site 266265016910 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266265016911 D-galactonate transporter; Region: 2A0114; TIGR00893 266265016912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016913 putative substrate translocation pore; other site 266265016914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016915 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 266265016916 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266265016917 putative active site [active] 266265016918 catalytic residue [active] 266265016919 galactarate dehydratase; Region: galactar-dH20; TIGR03248 266265016920 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 266265016921 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 266265016922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265016923 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265016924 NAD(P) binding site [chemical binding]; other site 266265016925 active site 266265016926 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265016927 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266265016928 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 266265016929 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 266265016930 DctM-like transporters; Region: DctM; pfam06808 266265016931 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 266265016932 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265016933 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265016934 trimer interface [polypeptide binding]; other site 266265016935 eyelet of channel; other site 266265016936 Urea transporter; Region: UT; pfam03253 266265016937 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 266265016938 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265016939 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265016940 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 266265016941 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 266265016942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265016943 short chain dehydrogenase; Provisional; Region: PRK07832 266265016944 NAD(P) binding site [chemical binding]; other site 266265016945 active site 266265016946 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266265016947 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266265016948 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 266265016949 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 266265016950 DNA binding residues [nucleotide binding] 266265016951 putative dimer interface [polypeptide binding]; other site 266265016952 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 266265016953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265016954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 266265016955 Coenzyme A binding pocket [chemical binding]; other site 266265016956 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 266265016957 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266265016958 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265016959 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 266265016960 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 266265016961 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 266265016962 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 266265016963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265016964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016965 putative substrate translocation pore; other site 266265016966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265016967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265016968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265016969 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 266265016970 Response regulator receiver domain; Region: Response_reg; pfam00072 266265016971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265016972 active site 266265016973 phosphorylation site [posttranslational modification] 266265016974 intermolecular recognition site; other site 266265016975 dimerization interface [polypeptide binding]; other site 266265016976 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 266265016977 metal binding site 2 [ion binding]; metal-binding site 266265016978 putative DNA binding helix; other site 266265016979 metal binding site 1 [ion binding]; metal-binding site 266265016980 dimer interface [polypeptide binding]; other site 266265016981 structural Zn2+ binding site [ion binding]; other site 266265016982 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265016983 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 266265016984 putative C-terminal domain interface [polypeptide binding]; other site 266265016985 putative GSH binding site (G-site) [chemical binding]; other site 266265016986 putative dimer interface [polypeptide binding]; other site 266265016987 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 266265016988 putative N-terminal domain interface [polypeptide binding]; other site 266265016989 putative dimer interface [polypeptide binding]; other site 266265016990 putative substrate binding pocket (H-site) [chemical binding]; other site 266265016991 Family description; Region: UvrD_C_2; pfam13538 266265016992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 266265016993 active site 266265016994 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 266265016995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265016996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265016997 dimer interface [polypeptide binding]; other site 266265016998 phosphorylation site [posttranslational modification] 266265016999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265017000 ATP binding site [chemical binding]; other site 266265017001 Mg2+ binding site [ion binding]; other site 266265017002 G-X-G motif; other site 266265017003 Response regulator receiver domain; Region: Response_reg; pfam00072 266265017004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265017005 active site 266265017006 phosphorylation site [posttranslational modification] 266265017007 intermolecular recognition site; other site 266265017008 dimerization interface [polypeptide binding]; other site 266265017009 BetR domain; Region: BetR; pfam08667 266265017010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265017011 active site 266265017012 phosphorylation site [posttranslational modification] 266265017013 intermolecular recognition site; other site 266265017014 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265017015 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265017016 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265017017 Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375 266265017018 ornithine cyclodeaminase; Validated; Region: PRK07340 266265017019 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266265017020 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 266265017021 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266265017022 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266265017023 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 266265017024 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 266265017025 dimer interface [polypeptide binding]; other site 266265017026 ADP-ribose binding site [chemical binding]; other site 266265017027 active site 266265017028 nudix motif; other site 266265017029 metal binding site [ion binding]; metal-binding site 266265017030 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 266265017031 haloacid dehalogenase-like hydrolase family protein; Region: PLN02770 266265017032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265017033 motif II; other site 266265017034 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 266265017035 active site 266265017036 catalytic residues [active] 266265017037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265017038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265017039 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266265017040 putative effector binding pocket; other site 266265017041 putative dimerization interface [polypeptide binding]; other site 266265017042 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266265017043 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 266265017044 putative NAD(P) binding site [chemical binding]; other site 266265017045 putative substrate binding site [chemical binding]; other site 266265017046 catalytic Zn binding site [ion binding]; other site 266265017047 structural Zn binding site [ion binding]; other site 266265017048 dimer interface [polypeptide binding]; other site 266265017049 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 266265017050 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265017051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265017053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017054 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 266265017055 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 266265017056 Moco binding site; other site 266265017057 metal coordination site [ion binding]; other site 266265017058 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 266265017059 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266265017060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265017061 active site 266265017062 phosphorylation site [posttranslational modification] 266265017063 intermolecular recognition site; other site 266265017064 dimerization interface [polypeptide binding]; other site 266265017065 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265017066 DNA binding site [nucleotide binding] 266265017067 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266265017068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265017069 dimerization interface [polypeptide binding]; other site 266265017070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265017071 dimer interface [polypeptide binding]; other site 266265017072 phosphorylation site [posttranslational modification] 266265017073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265017074 ATP binding site [chemical binding]; other site 266265017075 Mg2+ binding site [ion binding]; other site 266265017076 G-X-G motif; other site 266265017077 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 266265017078 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 266265017079 PhnA protein; Region: PhnA; pfam03831 266265017080 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266265017081 PAS domain; Region: PAS_9; pfam13426 266265017082 PAS domain; Region: PAS_9; pfam13426 266265017083 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265017084 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265017085 metal binding site [ion binding]; metal-binding site 266265017086 active site 266265017087 I-site; other site 266265017088 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 266265017089 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 266265017090 putative ligand binding site [chemical binding]; other site 266265017091 NAD binding site [chemical binding]; other site 266265017092 catalytic site [active] 266265017093 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266265017094 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 266265017095 molybdopterin cofactor binding site; other site 266265017096 The MopB_2 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_2; cd02763 266265017097 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 266265017098 putative molybdopterin cofactor binding site [chemical binding]; other site 266265017099 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 266265017100 putative molybdopterin cofactor binding site; other site 266265017101 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 266265017102 4Fe-4S binding domain; Region: Fer4; pfam00037 266265017103 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 266265017104 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265017105 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266265017106 conserved cys residue [active] 266265017107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017109 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266265017110 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 266265017111 active site 266265017112 tetramer interface; other site 266265017113 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265017114 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266265017115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017117 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 266265017118 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 266265017119 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266265017120 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 266265017121 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266265017122 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266265017123 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 266265017124 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266265017125 SLBB domain; Region: SLBB; pfam10531 266265017126 SLBB domain; Region: SLBB; pfam10531 266265017127 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266265017128 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266265017129 active site 266265017130 tyrosine kinase; Provisional; Region: PRK11519 266265017131 Chain length determinant protein; Region: Wzz; pfam02706 266265017132 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266265017133 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265017134 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266265017135 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266265017136 Probable Catalytic site; other site 266265017137 metal-binding site 266265017138 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266265017139 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 266265017140 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 266265017141 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 266265017142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265017143 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265017144 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265017145 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265017146 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265017147 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265017148 Right handed beta helix region; Region: Beta_helix; pfam13229 266265017149 Disaggregatase related; Region: Disaggr_assoc; pfam08480 266265017150 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 266265017151 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 266265017152 substrate binding site; other site 266265017153 tetramer interface; other site 266265017154 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 266265017155 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 266265017156 NAD binding site [chemical binding]; other site 266265017157 substrate binding site [chemical binding]; other site 266265017158 homodimer interface [polypeptide binding]; other site 266265017159 active site 266265017160 Response regulator receiver domain; Region: Response_reg; pfam00072 266265017161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265017162 active site 266265017163 phosphorylation site [posttranslational modification] 266265017164 intermolecular recognition site; other site 266265017165 dimerization interface [polypeptide binding]; other site 266265017166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265017167 DNA binding residues [nucleotide binding] 266265017168 Na binding site [ion binding]; other site 266265017169 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 266265017170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265017171 dimer interface [polypeptide binding]; other site 266265017172 phosphorylation site [posttranslational modification] 266265017173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265017174 ATP binding site [chemical binding]; other site 266265017175 Mg2+ binding site [ion binding]; other site 266265017176 G-X-G motif; other site 266265017177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265017178 active site 266265017179 phosphorylation site [posttranslational modification] 266265017180 intermolecular recognition site; other site 266265017181 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265017182 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 266265017183 putative ligand binding site [chemical binding]; other site 266265017184 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265017185 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265017186 TM-ABC transporter signature motif; other site 266265017187 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265017188 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265017189 TM-ABC transporter signature motif; other site 266265017190 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 266265017191 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265017192 Walker A/P-loop; other site 266265017193 ATP binding site [chemical binding]; other site 266265017194 Q-loop/lid; other site 266265017195 ABC transporter signature motif; other site 266265017196 Walker B; other site 266265017197 D-loop; other site 266265017198 H-loop/switch region; other site 266265017199 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 266265017200 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265017201 Walker A/P-loop; other site 266265017202 ATP binding site [chemical binding]; other site 266265017203 Q-loop/lid; other site 266265017204 ABC transporter signature motif; other site 266265017205 Walker B; other site 266265017206 D-loop; other site 266265017207 H-loop/switch region; other site 266265017208 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 266265017209 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 266265017210 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 266265017211 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 266265017212 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 266265017213 active site 266265017214 dimer interface [polypeptide binding]; other site 266265017215 effector binding site; other site 266265017216 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 266265017217 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266265017218 Putative esterase; Region: Esterase; pfam00756 266265017219 OpgC protein; Region: OpgC_C; pfam10129 266265017220 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265017221 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265017222 eyelet of channel; other site 266265017223 trimer interface [polypeptide binding]; other site 266265017224 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266265017225 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 266265017226 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 266265017227 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266265017228 Peptidase family M23; Region: Peptidase_M23; pfam01551 266265017229 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265017230 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265017231 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265017232 catalytic loop [active] 266265017233 iron binding site [ion binding]; other site 266265017234 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265017235 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265017236 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265017237 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265017238 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265017239 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265017240 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265017241 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265017242 Cytochrome c; Region: Cytochrom_C; pfam00034 266265017243 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265017244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017245 dimer interface [polypeptide binding]; other site 266265017246 conserved gate region; other site 266265017247 putative PBP binding loops; other site 266265017248 ABC-ATPase subunit interface; other site 266265017249 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265017250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017251 dimer interface [polypeptide binding]; other site 266265017252 conserved gate region; other site 266265017253 putative PBP binding loops; other site 266265017254 ABC-ATPase subunit interface; other site 266265017255 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265017256 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265017257 substrate binding pocket [chemical binding]; other site 266265017258 membrane-bound complex binding site; other site 266265017259 hinge residues; other site 266265017260 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265017261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265017262 Walker A/P-loop; other site 266265017263 ATP binding site [chemical binding]; other site 266265017264 Q-loop/lid; other site 266265017265 ABC transporter signature motif; other site 266265017266 Walker B; other site 266265017267 D-loop; other site 266265017268 H-loop/switch region; other site 266265017269 TOBE domain; Region: TOBE_2; pfam08402 266265017270 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265017271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017272 dimer interface [polypeptide binding]; other site 266265017273 conserved gate region; other site 266265017274 putative PBP binding loops; other site 266265017275 ABC-ATPase subunit interface; other site 266265017276 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266265017277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017278 dimer interface [polypeptide binding]; other site 266265017279 conserved gate region; other site 266265017280 putative PBP binding loops; other site 266265017281 ABC-ATPase subunit interface; other site 266265017282 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266265017283 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265017284 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265017285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265017286 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265017287 substrate binding pocket [chemical binding]; other site 266265017288 dimerization interface [polypeptide binding]; other site 266265017289 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 266265017290 BON domain; Region: BON; pfam04972 266265017291 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 266265017292 active site 266265017293 DNA binding site [nucleotide binding] 266265017294 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265017295 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 266265017296 FOG: CBS domain [General function prediction only]; Region: COG0517 266265017297 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 266265017298 dimerization interface [polypeptide binding]; other site 266265017299 active site 266265017300 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266265017301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265017302 NAD(P) binding site [chemical binding]; other site 266265017303 active site 266265017304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017305 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265017306 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 266265017307 Putative zinc-finger; Region: zf-HC2; pfam13490 266265017308 RNA polymerase sigma factor; Provisional; Region: PRK12511 266265017309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265017310 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265017311 DNA binding residues [nucleotide binding] 266265017312 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265017313 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 266265017314 putative heme binding pocket [chemical binding]; other site 266265017315 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266265017316 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265017317 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265017318 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 266265017319 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 266265017320 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266265017321 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266265017322 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 266265017323 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266265017324 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 266265017325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265017326 ATP binding site [chemical binding]; other site 266265017327 putative Mg++ binding site [ion binding]; other site 266265017328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265017329 nucleotide binding region [chemical binding]; other site 266265017330 ATP-binding site [chemical binding]; other site 266265017331 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266265017332 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 266265017333 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265017334 E3 interaction surface; other site 266265017335 lipoyl attachment site [posttranslational modification]; other site 266265017336 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265017337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265017338 active site 266265017339 phosphorylation site [posttranslational modification] 266265017340 intermolecular recognition site; other site 266265017341 dimerization interface [polypeptide binding]; other site 266265017342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265017343 DNA binding site [nucleotide binding] 266265017344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 266265017345 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 266265017346 FecR protein; Region: FecR; pfam04773 266265017347 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 266265017348 CHASE2 domain; Region: CHASE2; pfam05226 266265017349 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266265017350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265017351 dimer interface [polypeptide binding]; other site 266265017352 phosphorylation site [posttranslational modification] 266265017353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265017354 ATP binding site [chemical binding]; other site 266265017355 Mg2+ binding site [ion binding]; other site 266265017356 G-X-G motif; other site 266265017357 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 266265017358 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 266265017359 putative FMN binding site [chemical binding]; other site 266265017360 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 266265017361 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 266265017362 catalytic triad [active] 266265017363 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 266265017364 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 266265017365 homodimer interface [polypeptide binding]; other site 266265017366 Walker A motif; other site 266265017367 ATP binding site [chemical binding]; other site 266265017368 hydroxycobalamin binding site [chemical binding]; other site 266265017369 Walker B motif; other site 266265017370 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 266265017371 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265017372 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 266265017373 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 266265017374 active site 266265017375 SAM binding site [chemical binding]; other site 266265017376 homodimer interface [polypeptide binding]; other site 266265017377 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 266265017378 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 266265017379 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 266265017380 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 266265017381 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 266265017382 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 266265017383 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 266265017384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265017385 Walker A motif; other site 266265017386 ATP binding site [chemical binding]; other site 266265017387 Walker B motif; other site 266265017388 arginine finger; other site 266265017389 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266265017390 metal ion-dependent adhesion site (MIDAS); other site 266265017391 Flagellar protein YcgR; Region: YcgR_2; pfam12945 266265017392 PilZ domain; Region: PilZ; pfam07238 266265017393 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 266265017394 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 266265017395 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 266265017396 FtsX-like permease family; Region: FtsX; pfam02687 266265017397 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 266265017398 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 266265017399 Walker A/P-loop; other site 266265017400 ATP binding site [chemical binding]; other site 266265017401 Q-loop/lid; other site 266265017402 ABC transporter signature motif; other site 266265017403 Walker B; other site 266265017404 D-loop; other site 266265017405 H-loop/switch region; other site 266265017406 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 266265017407 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266265017408 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 266265017409 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266265017410 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 266265017411 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266265017412 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266265017413 D-pathway; other site 266265017414 Putative ubiquinol binding site [chemical binding]; other site 266265017415 Low-spin heme (heme b) binding site [chemical binding]; other site 266265017416 Putative water exit pathway; other site 266265017417 Binuclear center (heme o3/CuB) [ion binding]; other site 266265017418 K-pathway; other site 266265017419 Putative proton exit pathway; other site 266265017420 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 266265017421 Subunit I/III interface [polypeptide binding]; other site 266265017422 Subunit III/IV interface [polypeptide binding]; other site 266265017423 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 266265017424 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266265017425 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265017426 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 266265017427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265017428 motif II; other site 266265017429 RNA polymerase sigma factor; Reviewed; Region: PRK05602 266265017430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265017431 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265017432 Heavy-metal resistance; Region: Metal_resist; pfam13801 266265017433 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 266265017434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 266265017435 BON domain; Region: BON; pfam04972 266265017436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265017437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265017438 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 266265017439 putative effector binding pocket; other site 266265017440 putative dimerization interface [polypeptide binding]; other site 266265017441 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266265017442 tartrate dehydrogenase; Region: TTC; TIGR02089 266265017443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265017444 D-galactonate transporter; Region: 2A0114; TIGR00893 266265017445 putative substrate translocation pore; other site 266265017446 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 266265017447 diiron binding motif [ion binding]; other site 266265017448 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 266265017449 benzoate transporter; Region: benE; TIGR00843 266265017450 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 266265017451 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 266265017452 Walker A/P-loop; other site 266265017453 ATP binding site [chemical binding]; other site 266265017454 Q-loop/lid; other site 266265017455 ABC transporter signature motif; other site 266265017456 Walker B; other site 266265017457 D-loop; other site 266265017458 H-loop/switch region; other site 266265017459 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 266265017460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017461 dimer interface [polypeptide binding]; other site 266265017462 conserved gate region; other site 266265017463 putative PBP binding loops; other site 266265017464 ABC-ATPase subunit interface; other site 266265017465 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265017466 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266265017467 conserved cys residue [active] 266265017468 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 266265017469 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266265017470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266265017471 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266265017472 lipoprotein signal peptidase; Provisional; Region: PRK14776 266265017473 Heavy-metal-associated domain; Region: HMA; pfam00403 266265017474 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265017475 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266265017476 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266265017477 DNA binding residues [nucleotide binding] 266265017478 dimer interface [polypeptide binding]; other site 266265017479 putative metal binding site [ion binding]; other site 266265017480 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265017481 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266265017482 conserved cys residue [active] 266265017483 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266265017484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017485 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266265017486 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266265017487 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 266265017488 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 266265017489 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265017490 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 266265017491 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 266265017492 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266265017493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265017494 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 266265017495 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 266265017496 benzoate transport; Region: 2A0115; TIGR00895 266265017497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265017498 putative substrate translocation pore; other site 266265017499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265017500 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 266265017501 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 266265017502 choline dehydrogenase; Validated; Region: PRK02106 266265017503 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265017504 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 266265017505 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 266265017506 tetrameric interface [polypeptide binding]; other site 266265017507 NAD binding site [chemical binding]; other site 266265017508 catalytic residues [active] 266265017509 transcriptional regulator BetI; Validated; Region: PRK00767 266265017510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265017511 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 266265017512 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 266265017513 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 266265017514 NAD binding site [chemical binding]; other site 266265017515 catalytic Zn binding site [ion binding]; other site 266265017516 structural Zn binding site [ion binding]; other site 266265017517 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265017518 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266265017519 conserved cys residue [active] 266265017520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017521 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 266265017522 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 266265017523 dimer interface [polypeptide binding]; other site 266265017524 active site 266265017525 glycine-pyridoxal phosphate binding site [chemical binding]; other site 266265017526 folate binding site [chemical binding]; other site 266265017527 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 266265017528 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 266265017529 active site 266265017530 dimer interface [polypeptide binding]; other site 266265017531 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 266265017532 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 266265017533 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 266265017534 putative active site [active] 266265017535 putative FMN binding site [chemical binding]; other site 266265017536 putative substrate binding site [chemical binding]; other site 266265017537 putative catalytic residue [active] 266265017538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265017539 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 266265017540 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266265017541 Cysteine-rich domain; Region: CCG; pfam02754 266265017542 Cysteine-rich domain; Region: CCG; pfam02754 266265017543 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266265017544 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266265017545 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 266265017546 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266265017547 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265017548 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265017549 [2Fe-2S] cluster binding site [ion binding]; other site 266265017550 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 266265017551 putative alpha subunit interface [polypeptide binding]; other site 266265017552 putative active site [active] 266265017553 putative substrate binding site [chemical binding]; other site 266265017554 Fe binding site [ion binding]; other site 266265017555 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265017556 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 266265017557 FAD binding pocket [chemical binding]; other site 266265017558 FAD binding motif [chemical binding]; other site 266265017559 phosphate binding motif [ion binding]; other site 266265017560 beta-alpha-beta structure motif; other site 266265017561 NAD binding pocket [chemical binding]; other site 266265017562 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265017563 catalytic loop [active] 266265017564 iron binding site [ion binding]; other site 266265017565 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 266265017566 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266265017567 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 266265017568 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 266265017569 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 266265017570 putative active site [active] 266265017571 putative substrate binding site [chemical binding]; other site 266265017572 putative cosubstrate binding site; other site 266265017573 catalytic site [active] 266265017574 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 266265017575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265017576 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265017577 dimerization interface [polypeptide binding]; other site 266265017578 substrate binding pocket [chemical binding]; other site 266265017579 Sulfatase; Region: Sulfatase; cl17466 266265017580 choline-sulfatase; Region: chol_sulfatase; TIGR03417 266265017581 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 266265017582 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266265017583 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 266265017584 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265017585 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265017586 trimer interface [polypeptide binding]; other site 266265017587 eyelet of channel; other site 266265017588 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266265017589 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266265017590 ring oligomerisation interface [polypeptide binding]; other site 266265017591 ATP/Mg binding site [chemical binding]; other site 266265017592 stacking interactions; other site 266265017593 hinge regions; other site 266265017594 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266265017595 oligomerisation interface [polypeptide binding]; other site 266265017596 mobile loop; other site 266265017597 roof hairpin; other site 266265017598 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266265017599 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266265017600 Flavin binding site [chemical binding]; other site 266265017601 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265017602 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 266265017603 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266265017604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017605 dimer interface [polypeptide binding]; other site 266265017606 conserved gate region; other site 266265017607 putative PBP binding loops; other site 266265017608 ABC-ATPase subunit interface; other site 266265017609 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266265017610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017611 dimer interface [polypeptide binding]; other site 266265017612 conserved gate region; other site 266265017613 putative PBP binding loops; other site 266265017614 ABC-ATPase subunit interface; other site 266265017615 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266265017616 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265017617 Walker A/P-loop; other site 266265017618 ATP binding site [chemical binding]; other site 266265017619 Q-loop/lid; other site 266265017620 ABC transporter signature motif; other site 266265017621 Walker B; other site 266265017622 D-loop; other site 266265017623 H-loop/switch region; other site 266265017624 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265017625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265017626 Walker A/P-loop; other site 266265017627 ATP binding site [chemical binding]; other site 266265017628 Q-loop/lid; other site 266265017629 ABC transporter signature motif; other site 266265017630 Walker B; other site 266265017631 D-loop; other site 266265017632 H-loop/switch region; other site 266265017633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265017634 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266265017635 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266265017636 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266265017637 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 266265017638 active site residue [active] 266265017639 serine O-acetyltransferase; Region: cysE; TIGR01172 266265017640 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266265017641 trimer interface [polypeptide binding]; other site 266265017642 active site 266265017643 substrate binding site [chemical binding]; other site 266265017644 CoA binding site [chemical binding]; other site 266265017645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265017646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265017647 non-specific DNA binding site [nucleotide binding]; other site 266265017648 salt bridge; other site 266265017649 sequence-specific DNA binding site [nucleotide binding]; other site 266265017650 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266265017651 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 266265017652 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265017653 catalytic residue [active] 266265017654 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266265017655 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266265017656 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265017657 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265017658 active site 266265017659 non-prolyl cis peptide bond; other site 266265017660 PCI domain; Region: PCI; cl02111 266265017661 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265017662 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265017663 substrate binding pocket [chemical binding]; other site 266265017664 membrane-bound complex binding site; other site 266265017665 hinge residues; other site 266265017666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017667 dimer interface [polypeptide binding]; other site 266265017668 conserved gate region; other site 266265017669 putative PBP binding loops; other site 266265017670 ABC-ATPase subunit interface; other site 266265017671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017672 dimer interface [polypeptide binding]; other site 266265017673 conserved gate region; other site 266265017674 putative PBP binding loops; other site 266265017675 ABC-ATPase subunit interface; other site 266265017676 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266265017677 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266265017678 Flavin binding site [chemical binding]; other site 266265017679 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266265017680 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266265017681 Flavin binding site [chemical binding]; other site 266265017682 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265017683 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265017684 active site 266265017685 non-prolyl cis peptide bond; other site 266265017686 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266265017687 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 266265017688 active site 266265017689 dimer interface [polypeptide binding]; other site 266265017690 non-prolyl cis peptide bond; other site 266265017691 insertion regions; other site 266265017692 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265017693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017694 dimer interface [polypeptide binding]; other site 266265017695 conserved gate region; other site 266265017696 putative PBP binding loops; other site 266265017697 ABC-ATPase subunit interface; other site 266265017698 NMT1-like family; Region: NMT1_2; pfam13379 266265017699 NMT1/THI5 like; Region: NMT1; pfam09084 266265017700 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265017701 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265017702 Walker A/P-loop; other site 266265017703 ATP binding site [chemical binding]; other site 266265017704 Q-loop/lid; other site 266265017705 ABC transporter signature motif; other site 266265017706 Walker B; other site 266265017707 D-loop; other site 266265017708 H-loop/switch region; other site 266265017709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265017710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265017711 active site 266265017712 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266265017713 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266265017714 Cupin; Region: Cupin_6; pfam12852 266265017715 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265017716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017717 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 266265017718 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265017719 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266265017720 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 266265017721 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 266265017722 substrate binding site [chemical binding]; other site 266265017723 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 266265017724 substrate binding site [chemical binding]; other site 266265017725 ligand binding site [chemical binding]; other site 266265017726 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 266265017727 active site 266265017728 barstar interaction site; other site 266265017729 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 266265017730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265017731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265017732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265017733 dimerization interface [polypeptide binding]; other site 266265017734 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266265017735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265017736 putative substrate translocation pore; other site 266265017737 classical (c) SDRs; Region: SDR_c; cd05233 266265017738 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266265017739 NAD(P) binding site [chemical binding]; other site 266265017740 active site 266265017741 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 266265017742 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265017743 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265017744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265017745 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265017746 putative substrate translocation pore; other site 266265017747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265017748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265017749 ATP binding site [chemical binding]; other site 266265017750 Mg2+ binding site [ion binding]; other site 266265017751 G-X-G motif; other site 266265017752 CheB methylesterase; Region: CheB_methylest; pfam01339 266265017753 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 266265017754 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266265017755 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 266265017756 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 266265017757 PAS domain; Region: PAS_10; pfam13596 266265017758 PAS domain S-box; Region: sensory_box; TIGR00229 266265017759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265017760 putative active site [active] 266265017761 heme pocket [chemical binding]; other site 266265017762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265017763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265017764 dimer interface [polypeptide binding]; other site 266265017765 phosphorylation site [posttranslational modification] 266265017766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265017767 ATP binding site [chemical binding]; other site 266265017768 Mg2+ binding site [ion binding]; other site 266265017769 G-X-G motif; other site 266265017770 Response regulator receiver domain; Region: Response_reg; pfam00072 266265017771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265017772 active site 266265017773 phosphorylation site [posttranslational modification] 266265017774 intermolecular recognition site; other site 266265017775 dimerization interface [polypeptide binding]; other site 266265017776 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265017777 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265017778 ligand binding site [chemical binding]; other site 266265017779 flexible hinge region; other site 266265017780 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266265017781 phosphoglucomutase; Validated; Region: PRK07564 266265017782 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 266265017783 active site 266265017784 substrate binding site [chemical binding]; other site 266265017785 metal binding site [ion binding]; metal-binding site 266265017786 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266265017787 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 266265017788 Putative glucoamylase; Region: Glycoamylase; pfam10091 266265017789 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 266265017790 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 266265017791 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 266265017792 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 266265017793 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 266265017794 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 266265017795 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 266265017796 Soluble P-type ATPase [General function prediction only]; Region: COG4087 266265017797 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 266265017798 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 266265017799 putative active site [active] 266265017800 Zn binding site [ion binding]; other site 266265017801 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266265017802 CoA binding domain; Region: CoA_binding_2; pfam13380 266265017803 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266265017804 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266265017805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266265017806 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266265017807 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 266265017808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265017809 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265017810 dimerization interface [polypeptide binding]; other site 266265017811 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265017812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265017813 Walker A/P-loop; other site 266265017814 ATP binding site [chemical binding]; other site 266265017815 Q-loop/lid; other site 266265017816 ABC transporter signature motif; other site 266265017817 Walker B; other site 266265017818 D-loop; other site 266265017819 H-loop/switch region; other site 266265017820 TOBE domain; Region: TOBE_2; pfam08402 266265017821 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266265017822 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 266265017823 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265017824 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265017825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017826 dimer interface [polypeptide binding]; other site 266265017827 conserved gate region; other site 266265017828 putative PBP binding loops; other site 266265017829 ABC-ATPase subunit interface; other site 266265017830 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265017831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017832 dimer interface [polypeptide binding]; other site 266265017833 conserved gate region; other site 266265017834 putative PBP binding loops; other site 266265017835 ABC-ATPase subunit interface; other site 266265017836 HipA N-terminal domain; Region: Couple_hipA; pfam13657 266265017837 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 266265017838 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266265017839 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266265017840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265017841 non-specific DNA binding site [nucleotide binding]; other site 266265017842 salt bridge; other site 266265017843 sequence-specific DNA binding site [nucleotide binding]; other site 266265017844 choline dehydrogenase; Region: betA; TIGR01810 266265017845 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265017846 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266265017847 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266265017848 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017849 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265017850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265017851 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265017852 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265017853 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266265017854 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265017855 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266265017856 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266265017857 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266265017858 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265017859 Walker A/P-loop; other site 266265017860 ATP binding site [chemical binding]; other site 266265017861 Q-loop/lid; other site 266265017862 ABC transporter signature motif; other site 266265017863 Walker B; other site 266265017864 D-loop; other site 266265017865 H-loop/switch region; other site 266265017866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265017867 Walker A/P-loop; other site 266265017868 ATP binding site [chemical binding]; other site 266265017869 Q-loop/lid; other site 266265017870 ABC transporter signature motif; other site 266265017871 Walker B; other site 266265017872 D-loop; other site 266265017873 H-loop/switch region; other site 266265017874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266265017875 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266265017876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017877 dimer interface [polypeptide binding]; other site 266265017878 conserved gate region; other site 266265017879 ABC-ATPase subunit interface; other site 266265017880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266265017881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017882 dimer interface [polypeptide binding]; other site 266265017883 conserved gate region; other site 266265017884 putative PBP binding loops; other site 266265017885 ABC-ATPase subunit interface; other site 266265017886 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265017887 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266265017888 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265017889 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265017890 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266265017891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265017892 motif II; other site 266265017893 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265017894 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265017895 NAD(P) binding site [chemical binding]; other site 266265017896 catalytic residues [active] 266265017897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266265017898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265017899 Coenzyme A binding pocket [chemical binding]; other site 266265017900 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266265017901 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 266265017902 putative ligand binding site [chemical binding]; other site 266265017903 NAD binding site [chemical binding]; other site 266265017904 dimerization interface [polypeptide binding]; other site 266265017905 catalytic site [active] 266265017906 hypothetical protein; Provisional; Region: PRK05965 266265017907 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265017908 inhibitor-cofactor binding pocket; inhibition site 266265017909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265017910 catalytic residue [active] 266265017911 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265017912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265017913 putative DNA binding site [nucleotide binding]; other site 266265017914 putative Zn2+ binding site [ion binding]; other site 266265017915 AsnC family; Region: AsnC_trans_reg; pfam01037 266265017916 transcriptional activator TtdR; Provisional; Region: PRK09801 266265017917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265017918 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 266265017919 putative effector binding pocket; other site 266265017920 putative dimerization interface [polypeptide binding]; other site 266265017921 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266265017922 tartrate dehydrogenase; Region: TTC; TIGR02089 266265017923 succinic semialdehyde dehydrogenase; Region: PLN02278 266265017924 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266265017925 tetramerization interface [polypeptide binding]; other site 266265017926 NAD(P) binding site [chemical binding]; other site 266265017927 catalytic residues [active] 266265017928 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 266265017929 putative active site [active] 266265017930 Zn binding site [ion binding]; other site 266265017931 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 266265017932 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 266265017933 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 266265017934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265017935 Walker A/P-loop; other site 266265017936 ATP binding site [chemical binding]; other site 266265017937 ABC transporter; Region: ABC_tran; pfam00005 266265017938 Q-loop/lid; other site 266265017939 ABC transporter signature motif; other site 266265017940 Walker B; other site 266265017941 D-loop; other site 266265017942 H-loop/switch region; other site 266265017943 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266265017944 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266265017945 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 266265017946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265017947 dimer interface [polypeptide binding]; other site 266265017948 conserved gate region; other site 266265017949 putative PBP binding loops; other site 266265017950 ABC-ATPase subunit interface; other site 266265017951 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266265017952 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266265017953 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 266265017954 heme-binding site [chemical binding]; other site 266265017955 NifQ; Region: NifQ; pfam04891 266265017956 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 266265017957 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 266265017958 Rop-like; Region: Rop-like; pfam05082 266265017959 probable nitrogen fixation protein; Region: TIGR02935 266265017960 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 266265017961 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 266265017962 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 266265017963 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 266265017964 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 266265017965 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 266265017966 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 266265017967 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 266265017968 MoFe protein beta/alpha subunit interactions; other site 266265017969 Beta subunit P cluster binding residues; other site 266265017970 MoFe protein beta subunit/Fe protein contacts; other site 266265017971 MoFe protein dimer/ dimer interactions; other site 266265017972 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 266265017973 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 266265017974 MoFe protein alpha/beta subunit interactions; other site 266265017975 Alpha subunit P cluster binding residues; other site 266265017976 FeMoco binding residues [chemical binding]; other site 266265017977 MoFe protein alpha subunit/Fe protein contacts; other site 266265017978 MoFe protein dimer/ dimer interactions; other site 266265017979 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 266265017980 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 266265017981 Nucleotide-binding sites [chemical binding]; other site 266265017982 Walker A motif; other site 266265017983 Switch I region of nucleotide binding site; other site 266265017984 Fe4S4 binding sites [ion binding]; other site 266265017985 Switch II region of nucleotide binding site; other site 266265017986 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 266265017987 apolar tunnel; other site 266265017988 heme binding site [chemical binding]; other site 266265017989 dimerization interface [polypeptide binding]; other site 266265017990 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266265017991 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266265017992 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266265017993 active site residue [active] 266265017994 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266265017995 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266265017996 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 266265017997 putative catalytic residues [active] 266265017998 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 266265017999 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265018000 catalytic loop [active] 266265018001 iron binding site [ion binding]; other site 266265018002 SIR2-like domain; Region: SIR2_2; pfam13289 266265018003 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 266265018004 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 266265018005 inhibitor-cofactor binding pocket; inhibition site 266265018006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265018007 catalytic residue [active] 266265018008 NifT/FixU protein; Region: NifT; pfam06988 266265018009 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 266265018010 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266265018011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265018012 catalytic residue [active] 266265018013 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 266265018014 NifZ domain; Region: NifZ; pfam04319 266265018015 NifZ domain; Region: NifZ; pfam04319 266265018016 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 266265018017 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266265018018 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 266265018019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265018020 FeS/SAM binding site; other site 266265018021 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 266265018022 Nif-specific regulatory protein; Region: nifA; TIGR01817 266265018023 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266265018024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265018025 Walker A motif; other site 266265018026 ATP binding site [chemical binding]; other site 266265018027 Walker B motif; other site 266265018028 arginine finger; other site 266265018029 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265018030 cysteine desulfurase; Provisional; Region: PRK14012 266265018031 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 266265018032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265018033 catalytic residue [active] 266265018034 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 266265018035 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 266265018036 trimerization site [polypeptide binding]; other site 266265018037 active site 266265018038 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 266265018039 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 266265018040 chaperone protein HscA; Provisional; Region: hscA; PRK05183 266265018041 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 266265018042 nucleotide binding site [chemical binding]; other site 266265018043 putative NEF/HSP70 interaction site [polypeptide binding]; other site 266265018044 SBD interface [polypeptide binding]; other site 266265018045 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266265018046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265018047 catalytic loop [active] 266265018048 iron binding site [ion binding]; other site 266265018049 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 266265018050 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 266265018051 active site 266265018052 catalytic residues [active] 266265018053 metal binding site [ion binding]; metal-binding site 266265018054 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 266265018055 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266265018056 Ligand binding site [chemical binding]; other site 266265018057 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266265018058 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266265018059 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266265018060 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266265018061 oxidoreductase; Provisional; Region: PRK10015 266265018062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265018063 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266265018064 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266265018065 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 266265018066 dimerization interface [polypeptide binding]; other site 266265018067 NAD binding site [chemical binding]; other site 266265018068 ligand binding site [chemical binding]; other site 266265018069 catalytic site [active] 266265018070 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266265018071 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265018072 putative NAD(P) binding site [chemical binding]; other site 266265018073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265018074 NAD(P) binding site [chemical binding]; other site 266265018075 active site 266265018076 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266265018077 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265018078 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266265018079 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265018080 Cupin domain; Region: Cupin_2; pfam07883 266265018081 Protein of unknown function (DUF521); Region: DUF521; pfam04412 266265018082 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 266265018083 substrate binding site [chemical binding]; other site 266265018084 ligand binding site [chemical binding]; other site 266265018085 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 266265018086 substrate binding site [chemical binding]; other site 266265018087 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 266265018088 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266265018089 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265018090 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265018091 DNA-binding site [nucleotide binding]; DNA binding site 266265018092 FCD domain; Region: FCD; pfam07729 266265018093 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 266265018094 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265018095 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 266265018096 active site 266265018097 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266265018098 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 266265018099 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 266265018100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265018101 NAD(P) binding site [chemical binding]; other site 266265018102 catalytic residues [active] 266265018103 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266265018104 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266265018105 inhibitor site; inhibition site 266265018106 active site 266265018107 dimer interface [polypeptide binding]; other site 266265018108 catalytic residue [active] 266265018109 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265018110 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265018111 benzoate transport; Region: 2A0115; TIGR00895 266265018112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018114 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265018115 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265018116 trimer interface [polypeptide binding]; other site 266265018117 eyelet of channel; other site 266265018118 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 266265018119 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265018120 metal binding site [ion binding]; metal-binding site 266265018121 active site 266265018122 I-site; other site 266265018123 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265018124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265018125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265018126 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 266265018127 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266265018128 putative effector binding pocket; other site 266265018129 putative dimerization interface [polypeptide binding]; other site 266265018130 short chain dehydrogenase; Provisional; Region: PRK12744 266265018131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265018132 NAD(P) binding site [chemical binding]; other site 266265018133 active site 266265018134 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266265018135 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 266265018136 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266265018137 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265018138 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265018139 TM-ABC transporter signature motif; other site 266265018140 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265018141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265018142 Walker A/P-loop; other site 266265018143 ATP binding site [chemical binding]; other site 266265018144 Q-loop/lid; other site 266265018145 ABC transporter signature motif; other site 266265018146 Walker B; other site 266265018147 D-loop; other site 266265018148 H-loop/switch region; other site 266265018149 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265018150 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 266265018151 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266265018152 ligand binding site [chemical binding]; other site 266265018153 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265018154 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265018155 TM-ABC transporter signature motif; other site 266265018156 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265018157 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266265018158 substrate binding site [chemical binding]; other site 266265018159 dimer interface [polypeptide binding]; other site 266265018160 ATP binding site [chemical binding]; other site 266265018161 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 266265018162 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265018163 NAD(P) binding site [chemical binding]; other site 266265018164 catalytic residues [active] 266265018165 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265018166 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 266265018167 intersubunit interface [polypeptide binding]; other site 266265018168 active site 266265018169 catalytic residue [active] 266265018170 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265018171 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265018172 Walker A/P-loop; other site 266265018173 ATP binding site [chemical binding]; other site 266265018174 Q-loop/lid; other site 266265018175 ABC transporter signature motif; other site 266265018176 Walker B; other site 266265018177 D-loop; other site 266265018178 H-loop/switch region; other site 266265018179 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265018180 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 266265018181 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265018182 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265018183 TM-ABC transporter signature motif; other site 266265018184 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 266265018185 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266265018186 putative ligand binding site [chemical binding]; other site 266265018187 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266265018188 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265018189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265018190 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265018191 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265018192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 266265018193 dimerization interface [polypeptide binding]; other site 266265018194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265018195 dimer interface [polypeptide binding]; other site 266265018196 phosphorylation site [posttranslational modification] 266265018197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265018198 ATP binding site [chemical binding]; other site 266265018199 Mg2+ binding site [ion binding]; other site 266265018200 G-X-G motif; other site 266265018201 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266265018202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265018203 active site 266265018204 phosphorylation site [posttranslational modification] 266265018205 intermolecular recognition site; other site 266265018206 dimerization interface [polypeptide binding]; other site 266265018207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265018208 DNA binding site [nucleotide binding] 266265018209 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 266265018210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 266265018211 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265018212 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265018213 Walker A/P-loop; other site 266265018214 ATP binding site [chemical binding]; other site 266265018215 Q-loop/lid; other site 266265018216 ABC transporter signature motif; other site 266265018217 Walker B; other site 266265018218 D-loop; other site 266265018219 H-loop/switch region; other site 266265018220 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265018221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265018222 dimer interface [polypeptide binding]; other site 266265018223 conserved gate region; other site 266265018224 putative PBP binding loops; other site 266265018225 ABC-ATPase subunit interface; other site 266265018226 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266265018227 Amidase; Region: Amidase; cl11426 266265018228 urea carboxylase; Region: urea_carbox; TIGR02712 266265018229 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266265018230 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266265018231 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 266265018232 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 266265018233 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 266265018234 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266265018235 carboxyltransferase (CT) interaction site; other site 266265018236 biotinylation site [posttranslational modification]; other site 266265018237 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 266265018238 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 266265018239 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 266265018240 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 266265018241 oxidase reductase; Provisional; Region: PTZ00273 266265018242 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 266265018243 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 266265018244 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 266265018245 MarR family; Region: MarR_2; cl17246 266265018246 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265018247 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 266265018248 rod shape-determining protein MreB; Provisional; Region: PRK13927 266265018249 MreB and similar proteins; Region: MreB_like; cd10225 266265018250 nucleotide binding site [chemical binding]; other site 266265018251 Mg binding site [ion binding]; other site 266265018252 putative protofilament interaction site [polypeptide binding]; other site 266265018253 RodZ interaction site [polypeptide binding]; other site 266265018254 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265018255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265018256 DNA-binding site [nucleotide binding]; DNA binding site 266265018257 FCD domain; Region: FCD; pfam07729 266265018258 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 266265018259 Isochorismatase family; Region: Isochorismatase; pfam00857 266265018260 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266265018261 catalytic triad [active] 266265018262 conserved cis-peptide bond; other site 266265018263 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 266265018264 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265018265 Walker A/P-loop; other site 266265018266 ATP binding site [chemical binding]; other site 266265018267 Q-loop/lid; other site 266265018268 ABC transporter signature motif; other site 266265018269 Walker B; other site 266265018270 D-loop; other site 266265018271 H-loop/switch region; other site 266265018272 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265018273 Isochorismatase family; Region: Isochorismatase; pfam00857 266265018274 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266265018275 catalytic triad [active] 266265018276 conserved cis-peptide bond; other site 266265018277 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265018278 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266265018279 TM-ABC transporter signature motif; other site 266265018280 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265018281 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 266265018282 TM-ABC transporter signature motif; other site 266265018283 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 266265018284 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 266265018285 putative ligand binding site [chemical binding]; other site 266265018286 allophanate hydrolase; Provisional; Region: PRK08186 266265018287 Amidase; Region: Amidase; cl11426 266265018288 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 266265018289 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265018290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265018291 DNA-binding site [nucleotide binding]; DNA binding site 266265018292 FCD domain; Region: FCD; pfam07729 266265018293 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 266265018294 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 266265018295 putative active site [active] 266265018296 putative catalytic site [active] 266265018297 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265018298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265018299 Walker A/P-loop; other site 266265018300 ATP binding site [chemical binding]; other site 266265018301 Q-loop/lid; other site 266265018302 ABC transporter signature motif; other site 266265018303 Walker B; other site 266265018304 D-loop; other site 266265018305 H-loop/switch region; other site 266265018306 TOBE domain; Region: TOBE_2; pfam08402 266265018307 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265018308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265018309 dimer interface [polypeptide binding]; other site 266265018310 conserved gate region; other site 266265018311 putative PBP binding loops; other site 266265018312 ABC-ATPase subunit interface; other site 266265018313 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265018314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265018315 dimer interface [polypeptide binding]; other site 266265018316 conserved gate region; other site 266265018317 putative PBP binding loops; other site 266265018318 ABC-ATPase subunit interface; other site 266265018319 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266265018320 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266265018321 Flavin binding site [chemical binding]; other site 266265018322 hypothetical protein; Provisional; Region: PRK11239 266265018323 Protein of unknown function, DUF480; Region: DUF480; pfam04337 266265018324 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 266265018325 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 266265018326 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265018327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265018328 sequence-specific DNA binding site [nucleotide binding]; other site 266265018329 salt bridge; other site 266265018330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266265018331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265018332 Coenzyme A binding pocket [chemical binding]; other site 266265018333 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 266265018334 CoenzymeA binding site [chemical binding]; other site 266265018335 subunit interaction site [polypeptide binding]; other site 266265018336 PHB binding site; other site 266265018337 drug efflux system protein MdtG; Provisional; Region: PRK09874 266265018338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018339 putative substrate translocation pore; other site 266265018340 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265018341 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 266265018342 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265018343 propionate/acetate kinase; Provisional; Region: PRK12379 266265018344 Acetokinase family; Region: Acetate_kinase; cl17229 266265018345 putative phosphoketolase; Provisional; Region: PRK05261 266265018346 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 266265018347 TPP-binding site; other site 266265018348 XFP C-terminal domain; Region: XFP_C; pfam09363 266265018349 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 266265018350 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 266265018351 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 266265018352 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 266265018353 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 266265018354 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265018355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265018356 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 266265018357 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 266265018358 catalytic residues [active] 266265018359 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 266265018360 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 266265018361 active site 266265018362 intersubunit interface [polypeptide binding]; other site 266265018363 catalytic residue [active] 266265018364 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266265018365 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265018366 substrate binding pocket [chemical binding]; other site 266265018367 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 266265018368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265018369 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 266265018370 dimer interface [polypeptide binding]; other site 266265018371 phosphorylation site [posttranslational modification] 266265018372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265018373 ATP binding site [chemical binding]; other site 266265018374 Mg2+ binding site [ion binding]; other site 266265018375 G-X-G motif; other site 266265018376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265018377 Response regulator receiver domain; Region: Response_reg; pfam00072 266265018378 active site 266265018379 phosphorylation site [posttranslational modification] 266265018380 intermolecular recognition site; other site 266265018381 dimerization interface [polypeptide binding]; other site 266265018382 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 266265018383 [2Fe-2S] cluster binding site [ion binding]; other site 266265018384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 266265018385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265018386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265018387 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 266265018388 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265018389 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 266265018390 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265018391 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265018392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018393 putative substrate translocation pore; other site 266265018394 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265018395 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 266265018396 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266265018397 Domain of unknown function DUF20; Region: UPF0118; pfam01594 266265018398 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 266265018399 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 266265018400 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 266265018401 active site 266265018402 catalytic site [active] 266265018403 PRC-barrel domain; Region: PRC; pfam05239 266265018404 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265018405 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265018406 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265018407 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265018408 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266265018409 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265018410 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265018411 catalytic loop [active] 266265018412 iron binding site [ion binding]; other site 266265018413 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265018414 short chain dehydrogenase; Provisional; Region: PRK06701 266265018415 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 266265018416 NAD binding site [chemical binding]; other site 266265018417 metal binding site [ion binding]; metal-binding site 266265018418 active site 266265018419 Response regulator receiver domain; Region: Response_reg; pfam00072 266265018420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265018421 active site 266265018422 phosphorylation site [posttranslational modification] 266265018423 intermolecular recognition site; other site 266265018424 dimerization interface [polypeptide binding]; other site 266265018425 ATP-dependent DNA ligase; Validated; Region: PRK09247 266265018426 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 266265018427 active site 266265018428 DNA binding site [nucleotide binding] 266265018429 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 266265018430 DNA binding site [nucleotide binding] 266265018431 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 266265018432 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266265018433 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266265018434 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265018435 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265018436 catalytic site [active] 266265018437 PAS domain S-box; Region: sensory_box; TIGR00229 266265018438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265018439 putative active site [active] 266265018440 heme pocket [chemical binding]; other site 266265018441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265018442 PAS fold; Region: PAS_3; pfam08447 266265018443 putative active site [active] 266265018444 heme pocket [chemical binding]; other site 266265018445 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 266265018446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265018447 putative active site [active] 266265018448 heme pocket [chemical binding]; other site 266265018449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265018450 dimer interface [polypeptide binding]; other site 266265018451 phosphorylation site [posttranslational modification] 266265018452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265018453 ATP binding site [chemical binding]; other site 266265018454 Mg2+ binding site [ion binding]; other site 266265018455 G-X-G motif; other site 266265018456 Response regulator receiver domain; Region: Response_reg; pfam00072 266265018457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265018458 active site 266265018459 phosphorylation site [posttranslational modification] 266265018460 intermolecular recognition site; other site 266265018461 dimerization interface [polypeptide binding]; other site 266265018462 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 266265018463 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 266265018464 TPP-binding site [chemical binding]; other site 266265018465 dimer interface [polypeptide binding]; other site 266265018466 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 266265018467 PYR/PP interface [polypeptide binding]; other site 266265018468 dimer interface [polypeptide binding]; other site 266265018469 TPP binding site [chemical binding]; other site 266265018470 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266265018471 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 266265018472 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 266265018473 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 266265018474 putative molybdopterin cofactor binding site [chemical binding]; other site 266265018475 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 266265018476 putative molybdopterin cofactor binding site; other site 266265018477 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 266265018478 Walker A motif; other site 266265018479 ATP binding site [chemical binding]; other site 266265018480 Walker B motif; other site 266265018481 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 266265018482 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 266265018483 metal ion-dependent adhesion site (MIDAS); other site 266265018484 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266265018485 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 266265018486 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 266265018487 putative active site [active] 266265018488 putative dimer interface [polypeptide binding]; other site 266265018489 MarC family integral membrane protein; Region: MarC; cl00919 266265018490 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 266265018491 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 266265018492 Na binding site [ion binding]; other site 266265018493 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 266265018494 PAAR motif; Region: PAAR_motif; pfam05488 266265018495 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266265018496 RHS Repeat; Region: RHS_repeat; pfam05593 266265018497 RHS Repeat; Region: RHS_repeat; pfam05593 266265018498 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266265018499 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 266265018500 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 266265018501 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 266265018502 RHS Repeat; Region: RHS_repeat; pfam05593 266265018503 RHS Repeat; Region: RHS_repeat; pfam05593 266265018504 RHS protein; Region: RHS; pfam03527 266265018505 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 266265018506 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 266265018507 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 266265018508 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 266265018509 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 266265018510 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 266265018511 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 266265018512 glycogen synthase; Provisional; Region: glgA; PRK00654 266265018513 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 266265018514 ADP-binding pocket [chemical binding]; other site 266265018515 homodimer interface [polypeptide binding]; other site 266265018516 Phytochelatin synthase; Region: Phytochelatin; pfam05023 266265018517 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265018518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265018519 metal binding site [ion binding]; metal-binding site 266265018520 active site 266265018521 I-site; other site 266265018522 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 266265018523 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265018524 putative NAD(P) binding site [chemical binding]; other site 266265018525 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 266265018526 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 266265018527 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266265018528 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266265018529 active site 266265018530 metal binding site [ion binding]; metal-binding site 266265018531 short chain dehydrogenase; Provisional; Region: PRK06172 266265018532 classical (c) SDRs; Region: SDR_c; cd05233 266265018533 NAD(P) binding site [chemical binding]; other site 266265018534 active site 266265018535 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266265018536 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266265018537 FMN binding site [chemical binding]; other site 266265018538 active site 266265018539 substrate binding site [chemical binding]; other site 266265018540 catalytic residue [active] 266265018541 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265018542 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 266265018543 putative C-terminal domain interface [polypeptide binding]; other site 266265018544 putative GSH binding site (G-site) [chemical binding]; other site 266265018545 putative dimer interface [polypeptide binding]; other site 266265018546 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 266265018547 putative N-terminal domain interface [polypeptide binding]; other site 266265018548 putative dimer interface [polypeptide binding]; other site 266265018549 putative substrate binding pocket (H-site) [chemical binding]; other site 266265018550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265018551 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265018552 active site 266265018553 catalytic tetrad [active] 266265018554 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 266265018555 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 266265018556 Epoxide hydrolase N terminus; Region: EHN; pfam06441 266265018557 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265018558 LrgA family; Region: LrgA; cl00608 266265018559 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266265018560 EamA-like transporter family; Region: EamA; pfam00892 266265018561 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 266265018562 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266265018563 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 266265018564 FMN binding site [chemical binding]; other site 266265018565 active site 266265018566 substrate binding site [chemical binding]; other site 266265018567 catalytic residue [active] 266265018568 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 266265018569 active site clefts [active] 266265018570 zinc binding site [ion binding]; other site 266265018571 dimer interface [polypeptide binding]; other site 266265018572 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 266265018573 active site clefts [active] 266265018574 zinc binding site [ion binding]; other site 266265018575 dimer interface [polypeptide binding]; other site 266265018576 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265018577 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265018578 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265018579 eyelet of channel; other site 266265018580 trimer interface [polypeptide binding]; other site 266265018581 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266265018582 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265018583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018585 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 266265018586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265018587 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 266265018588 putative dimerization interface [polypeptide binding]; other site 266265018589 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 266265018590 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 266265018591 THF binding site; other site 266265018592 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 266265018593 substrate binding site [chemical binding]; other site 266265018594 THF binding site; other site 266265018595 zinc-binding site [ion binding]; other site 266265018596 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 266265018597 active site 266265018598 SAM binding site [chemical binding]; other site 266265018599 homodimer interface [polypeptide binding]; other site 266265018600 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 266265018601 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 266265018602 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 266265018603 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 266265018604 active site 266265018605 putative homodimer interface [polypeptide binding]; other site 266265018606 SAM binding site [chemical binding]; other site 266265018607 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 266265018608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265018609 S-adenosylmethionine binding site [chemical binding]; other site 266265018610 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266265018611 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266265018612 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 266265018613 Precorrin-8X methylmutase; Region: CbiC; pfam02570 266265018614 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 266265018615 active site 266265018616 SAM binding site [chemical binding]; other site 266265018617 homodimer interface [polypeptide binding]; other site 266265018618 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 266265018619 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 266265018620 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 266265018621 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 266265018622 active site 266265018623 SAM binding site [chemical binding]; other site 266265018624 homodimer interface [polypeptide binding]; other site 266265018625 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 266265018626 Protein of unknown function (DUF796); Region: DUF796; pfam05638 266265018627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265018628 AAA domain; Region: AAA_23; pfam13476 266265018629 Walker A/P-loop; other site 266265018630 ATP binding site [chemical binding]; other site 266265018631 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 266265018632 active site 266265018633 metal binding site [ion binding]; metal-binding site 266265018634 DNA binding site [nucleotide binding] 266265018635 Predicted membrane protein [Function unknown]; Region: COG2733 266265018636 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 266265018637 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265018638 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266265018639 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265018640 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265018641 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265018642 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265018643 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265018644 trimer interface [polypeptide binding]; other site 266265018645 eyelet of channel; other site 266265018646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265018647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265018648 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265018649 putative effector binding pocket; other site 266265018650 dimerization interface [polypeptide binding]; other site 266265018651 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 266265018652 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265018653 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265018654 Ubiquitin 3 binding protein But2 C-terminal domain; Region: But2; pfam09792 266265018655 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 266265018656 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266265018657 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266265018658 aldolase II superfamily protein; Provisional; Region: PRK07044 266265018659 intersubunit interface [polypeptide binding]; other site 266265018660 active site 266265018661 Zn2+ binding site [ion binding]; other site 266265018662 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 266265018663 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265018664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265018665 homodimer interface [polypeptide binding]; other site 266265018666 catalytic residue [active] 266265018667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265018668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265018669 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266265018670 putative dimerization interface [polypeptide binding]; other site 266265018671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265018672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265018673 DNA binding residues [nucleotide binding] 266265018674 dimerization interface [polypeptide binding]; other site 266265018675 Response regulator receiver domain; Region: Response_reg; pfam00072 266265018676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265018677 active site 266265018678 phosphorylation site [posttranslational modification] 266265018679 intermolecular recognition site; other site 266265018680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265018681 dimerization interface [polypeptide binding]; other site 266265018682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265018683 dimer interface [polypeptide binding]; other site 266265018684 phosphorylation site [posttranslational modification] 266265018685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265018686 ATP binding site [chemical binding]; other site 266265018687 Mg2+ binding site [ion binding]; other site 266265018688 G-X-G motif; other site 266265018689 CheB methylesterase; Region: CheB_methylest; pfam01339 266265018690 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266265018691 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 266265018692 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 266265018693 CHASE3 domain; Region: CHASE3; pfam05227 266265018694 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266265018695 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 266265018696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265018697 dimer interface [polypeptide binding]; other site 266265018698 phosphorylation site [posttranslational modification] 266265018699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265018700 ATP binding site [chemical binding]; other site 266265018701 Mg2+ binding site [ion binding]; other site 266265018702 G-X-G motif; other site 266265018703 Response regulator receiver domain; Region: Response_reg; pfam00072 266265018704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265018705 active site 266265018706 phosphorylation site [posttranslational modification] 266265018707 intermolecular recognition site; other site 266265018708 dimerization interface [polypeptide binding]; other site 266265018709 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265018710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265018711 active site 266265018712 phosphorylation site [posttranslational modification] 266265018713 intermolecular recognition site; other site 266265018714 dimerization interface [polypeptide binding]; other site 266265018715 Response regulator receiver domain; Region: Response_reg; pfam00072 266265018716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265018717 active site 266265018718 phosphorylation site [posttranslational modification] 266265018719 intermolecular recognition site; other site 266265018720 dimerization interface [polypeptide binding]; other site 266265018721 hydroperoxidase II; Provisional; Region: katE; PRK11249 266265018722 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 266265018723 tetramer interface [polypeptide binding]; other site 266265018724 heme binding pocket [chemical binding]; other site 266265018725 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 266265018726 domain interactions; other site 266265018727 MltA-interacting protein MipA; Region: MipA; cl01504 266265018728 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 266265018729 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 266265018730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265018731 catalytic residue [active] 266265018732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265018733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265018734 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265018735 putative effector binding pocket; other site 266265018736 dimerization interface [polypeptide binding]; other site 266265018737 Pirin-related protein [General function prediction only]; Region: COG1741 266265018738 Pirin; Region: Pirin; pfam02678 266265018739 Predicted membrane protein [Function unknown]; Region: COG2259 266265018740 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 266265018741 Fatty acid desaturase; Region: FA_desaturase; pfam00487 266265018742 Di-iron ligands [ion binding]; other site 266265018743 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 266265018744 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 266265018745 catalytic residue [active] 266265018746 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 266265018747 catalytic residues [active] 266265018748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265018749 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265018750 peroxiredoxin; Region: AhpC; TIGR03137 266265018751 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 266265018752 dimer interface [polypeptide binding]; other site 266265018753 decamer (pentamer of dimers) interface [polypeptide binding]; other site 266265018754 catalytic triad [active] 266265018755 peroxidatic and resolving cysteines [active] 266265018756 Propionate catabolism activator; Region: PrpR_N; pfam06506 266265018757 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 266265018758 PAS domain; Region: PAS; smart00091 266265018759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265018760 Walker A motif; other site 266265018761 ATP binding site [chemical binding]; other site 266265018762 Walker B motif; other site 266265018763 arginine finger; other site 266265018764 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265018765 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266265018766 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266265018767 tetramer interface [polypeptide binding]; other site 266265018768 active site 266265018769 Mg2+/Mn2+ binding site [ion binding]; other site 266265018770 putative transporter; Provisional; Region: PRK10504 266265018771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018772 putative substrate translocation pore; other site 266265018773 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266265018774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265018775 Coenzyme A binding pocket [chemical binding]; other site 266265018776 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266265018777 Cation efflux family; Region: Cation_efflux; cl00316 266265018778 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 266265018779 SnoaL-like domain; Region: SnoaL_2; pfam12680 266265018780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265018782 putative substrate translocation pore; other site 266265018783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265018784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265018785 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266265018786 dimerization interface [polypeptide binding]; other site 266265018787 substrate binding pocket [chemical binding]; other site 266265018788 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 266265018789 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 266265018790 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 266265018791 Moco binding site; other site 266265018792 metal coordination site [ion binding]; other site 266265018793 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266265018794 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 266265018795 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 266265018796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265018797 dimer interface [polypeptide binding]; other site 266265018798 conserved gate region; other site 266265018799 putative PBP binding loops; other site 266265018800 ABC-ATPase subunit interface; other site 266265018801 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265018802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265018803 Walker A/P-loop; other site 266265018804 ATP binding site [chemical binding]; other site 266265018805 Q-loop/lid; other site 266265018806 ABC transporter signature motif; other site 266265018807 Walker B; other site 266265018808 D-loop; other site 266265018809 H-loop/switch region; other site 266265018810 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 266265018811 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 266265018812 active site 266265018813 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 266265018814 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266265018815 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 266265018816 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266265018817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265018818 Walker A motif; other site 266265018819 ATP binding site [chemical binding]; other site 266265018820 Walker B motif; other site 266265018821 arginine finger; other site 266265018822 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265018823 NIPSNAP; Region: NIPSNAP; pfam07978 266265018824 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266265018825 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 266265018826 DEAD/DEAH box helicase; Region: DEAD; pfam00270 266265018827 ATP binding site [chemical binding]; other site 266265018828 DEAD_2; Region: DEAD_2; pfam06733 266265018829 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 266265018830 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 266265018831 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266265018832 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 266265018833 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 266265018834 4Fe-4S binding domain; Region: Fer4; pfam00037 266265018835 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 266265018836 Cysteine-rich domain; Region: CCG; pfam02754 266265018837 Cysteine-rich domain; Region: CCG; pfam02754 266265018838 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265018839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265018840 DNA-binding site [nucleotide binding]; DNA binding site 266265018841 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266265018842 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 266265018843 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 266265018844 aspartate aminotransferase; Provisional; Region: PRK05764 266265018845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265018846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265018847 homodimer interface [polypeptide binding]; other site 266265018848 catalytic residue [active] 266265018849 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 266265018850 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 266265018851 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 266265018852 BON domain; Region: BON; pfam04972 266265018853 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 266265018854 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266265018855 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 266265018856 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 266265018857 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266265018858 proposed catalytic triad [active] 266265018859 conserved cys residue [active] 266265018860 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 266265018861 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 266265018862 active site 266265018863 DNA binding site [nucleotide binding] 266265018864 Int/Topo IB signature motif; other site 266265018865 catalytic residues [active] 266265018866 PRC-barrel domain; Region: PRC; pfam05239 266265018867 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 266265018868 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266265018869 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266265018870 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265018871 Cupin; Region: Cupin_6; pfam12852 266265018872 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265018873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265018874 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266265018875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265018876 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265018877 active site 266265018878 catalytic tetrad [active] 266265018879 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 266265018880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265018881 ATP binding site [chemical binding]; other site 266265018882 putative Mg++ binding site [ion binding]; other site 266265018883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265018884 nucleotide binding region [chemical binding]; other site 266265018885 ATP-binding site [chemical binding]; other site 266265018886 DEAD/H associated; Region: DEAD_assoc; pfam08494 266265018887 RNase II stability modulator; Provisional; Region: PRK10060 266265018888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265018889 putative active site [active] 266265018890 heme pocket [chemical binding]; other site 266265018891 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265018892 metal binding site [ion binding]; metal-binding site 266265018893 active site 266265018894 I-site; other site 266265018895 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265018896 enoyl-CoA hydratase; Validated; Region: PRK08788 266265018897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265018898 substrate binding site [chemical binding]; other site 266265018899 oxyanion hole (OAH) forming residues; other site 266265018900 trimer interface [polypeptide binding]; other site 266265018901 hypothetical protein; Provisional; Region: PRK07907 266265018902 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 266265018903 metal binding site [ion binding]; metal-binding site 266265018904 putative dimer interface [polypeptide binding]; other site 266265018905 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 266265018906 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 266265018907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018908 putative substrate translocation pore; other site 266265018909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265018911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265018912 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 266265018913 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265018914 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266265018915 hypothetical protein; Provisional; Region: PRK07483 266265018916 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265018917 inhibitor-cofactor binding pocket; inhibition site 266265018918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265018919 catalytic residue [active] 266265018920 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 266265018921 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266265018922 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265018923 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266265018924 putative active site [active] 266265018925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265018926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265018927 oxidoreductase; Provisional; Region: PRK06196 266265018928 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 266265018929 putative NAD(P) binding site [chemical binding]; other site 266265018930 active site 266265018931 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265018932 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 266265018933 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 266265018934 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 266265018935 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 266265018936 dimer interface [polypeptide binding]; other site 266265018937 active site 266265018938 citrylCoA binding site [chemical binding]; other site 266265018939 NADH binding [chemical binding]; other site 266265018940 cationic pore residues; other site 266265018941 oxalacetate/citrate binding site [chemical binding]; other site 266265018942 coenzyme A binding site [chemical binding]; other site 266265018943 catalytic triad [active] 266265018944 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265018945 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265018946 catalytic site [active] 266265018947 rod shape-determining protein MreB; Provisional; Region: PRK13930 266265018948 MreB and similar proteins; Region: MreB_like; cd10225 266265018949 nucleotide binding site [chemical binding]; other site 266265018950 Mg binding site [ion binding]; other site 266265018951 putative protofilament interaction site [polypeptide binding]; other site 266265018952 RodZ interaction site [polypeptide binding]; other site 266265018953 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 266265018954 putative hydrolase; Provisional; Region: PRK11460 266265018955 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265018956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265018957 putative substrate translocation pore; other site 266265018958 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 266265018959 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265018960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265018961 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 266265018962 glutaminase; Provisional; Region: PRK00971 266265018963 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265018964 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265018965 trimer interface [polypeptide binding]; other site 266265018966 eyelet of channel; other site 266265018967 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265018968 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 266265018969 NAD(P) binding site [chemical binding]; other site 266265018970 catalytic residues [active] 266265018971 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265018972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265018973 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 266265018974 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 266265018975 Flavoprotein; Region: Flavoprotein; pfam02441 266265018976 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265018977 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 266265018978 TM-ABC transporter signature motif; other site 266265018979 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 266265018980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265018981 Walker A/P-loop; other site 266265018982 ATP binding site [chemical binding]; other site 266265018983 Q-loop/lid; other site 266265018984 ABC transporter signature motif; other site 266265018985 Walker B; other site 266265018986 D-loop; other site 266265018987 H-loop/switch region; other site 266265018988 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 266265018989 zinc binding site [ion binding]; other site 266265018990 putative ligand binding site [chemical binding]; other site 266265018991 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 266265018992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265018993 thiamine pyrophosphate protein; Validated; Region: PRK08199 266265018994 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265018995 PYR/PP interface [polypeptide binding]; other site 266265018996 dimer interface [polypeptide binding]; other site 266265018997 TPP binding site [chemical binding]; other site 266265018998 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265018999 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266265019000 TPP-binding site [chemical binding]; other site 266265019001 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265019002 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265019003 trimer interface [polypeptide binding]; other site 266265019004 eyelet of channel; other site 266265019005 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 266265019006 zinc binding site [ion binding]; other site 266265019007 putative ligand binding site [chemical binding]; other site 266265019008 hypothetical protein; Provisional; Region: PRK07475 266265019009 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266265019010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265019011 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266265019012 [2Fe-2S] cluster binding site [ion binding]; other site 266265019013 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265019014 inter-subunit interface; other site 266265019015 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 266265019016 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 266265019017 putative alpha subunit interface [polypeptide binding]; other site 266265019018 putative active site [active] 266265019019 putative substrate binding site [chemical binding]; other site 266265019020 Fe binding site [ion binding]; other site 266265019021 Helix-turn-helix domain; Region: HTH_18; pfam12833 266265019022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265019023 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265019024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265019025 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266265019026 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266265019027 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266265019028 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266265019029 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 266265019030 putative acyl-acceptor binding pocket; other site 266265019031 Predicted transcriptional regulators [Transcription]; Region: COG1733 266265019032 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266265019033 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 266265019034 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265019035 putative NAD(P) binding site [chemical binding]; other site 266265019036 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 266265019037 Predicted transcriptional regulators [Transcription]; Region: COG1733 266265019038 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 266265019039 short chain dehydrogenase; Provisional; Region: PRK06500 266265019040 classical (c) SDRs; Region: SDR_c; cd05233 266265019041 NAD(P) binding site [chemical binding]; other site 266265019042 active site 266265019043 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 266265019044 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 266265019045 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 266265019046 Predicted transcriptional regulators [Transcription]; Region: COG1695 266265019047 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 266265019048 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 266265019049 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 266265019050 FAD binding pocket [chemical binding]; other site 266265019051 FAD binding motif [chemical binding]; other site 266265019052 phosphate binding motif [ion binding]; other site 266265019053 NAD binding pocket [chemical binding]; other site 266265019054 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266265019055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019056 putative substrate translocation pore; other site 266265019057 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 266265019058 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265019059 substrate binding site [chemical binding]; other site 266265019060 oxyanion hole (OAH) forming residues; other site 266265019061 trimer interface [polypeptide binding]; other site 266265019062 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 266265019063 enoyl-CoA hydratase; Provisional; Region: PRK09076 266265019064 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265019065 substrate binding site [chemical binding]; other site 266265019066 oxyanion hole (OAH) forming residues; other site 266265019067 trimer interface [polypeptide binding]; other site 266265019068 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265019069 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 266265019070 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266265019071 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266265019072 tetrameric interface [polypeptide binding]; other site 266265019073 NAD binding site [chemical binding]; other site 266265019074 catalytic residues [active] 266265019075 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266265019076 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 266265019077 active site 266265019078 acyl-activating enzyme (AAE) consensus motif; other site 266265019079 putative CoA binding site [chemical binding]; other site 266265019080 AMP binding site [chemical binding]; other site 266265019081 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265019082 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265019083 active site 266265019084 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266265019085 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265019086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265019087 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 266265019088 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 266265019089 dimer interface [polypeptide binding]; other site 266265019090 active site residues [active] 266265019091 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 266265019092 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 266265019093 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 266265019094 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266265019095 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266265019096 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265019097 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 266265019098 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 266265019099 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266265019100 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266265019101 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 266265019102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265019103 Walker A motif; other site 266265019104 ATP binding site [chemical binding]; other site 266265019105 Walker B motif; other site 266265019106 arginine finger; other site 266265019107 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265019108 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265019109 catalytic loop [active] 266265019110 iron binding site [ion binding]; other site 266265019111 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 266265019112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 266265019113 YheO-like PAS domain; Region: PAS_6; pfam08348 266265019114 HTH domain; Region: HTH_22; pfam13309 266265019115 Cell morphogenesis central region; Region: MOR2-PAG1_mid; pfam14228 266265019116 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 266265019117 rRNA binding site [nucleotide binding]; other site 266265019118 predicted 30S ribosome binding site; other site 266265019119 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266265019120 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 266265019121 putative NAD(P) binding site [chemical binding]; other site 266265019122 putative substrate binding site [chemical binding]; other site 266265019123 catalytic Zn binding site [ion binding]; other site 266265019124 structural Zn binding site [ion binding]; other site 266265019125 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265019126 MarR family; Region: MarR; pfam01047 266265019127 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265019128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265019129 substrate binding pocket [chemical binding]; other site 266265019130 membrane-bound complex binding site; other site 266265019131 hinge residues; other site 266265019132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265019133 dimer interface [polypeptide binding]; other site 266265019134 conserved gate region; other site 266265019135 putative PBP binding loops; other site 266265019136 ABC-ATPase subunit interface; other site 266265019137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265019138 dimer interface [polypeptide binding]; other site 266265019139 conserved gate region; other site 266265019140 putative PBP binding loops; other site 266265019141 ABC-ATPase subunit interface; other site 266265019142 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265019143 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265019144 Walker A/P-loop; other site 266265019145 ATP binding site [chemical binding]; other site 266265019146 Q-loop/lid; other site 266265019147 ABC transporter signature motif; other site 266265019148 Walker B; other site 266265019149 D-loop; other site 266265019150 H-loop/switch region; other site 266265019151 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 266265019152 amidase; Provisional; Region: PRK08310 266265019153 indole-3-acetamide amidohydrolase; Region: PLN02722 266265019154 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 266265019155 SnoaL-like domain; Region: SnoaL_3; pfam13474 266265019156 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 266265019157 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 266265019158 putative hydrophobic ligand binding site [chemical binding]; other site 266265019159 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 266265019160 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265019161 catalytic loop [active] 266265019162 iron binding site [ion binding]; other site 266265019163 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265019164 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 266265019165 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265019166 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265019167 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265019168 dihydroorotase; Provisional; Region: PRK09237 266265019169 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 266265019170 active site 266265019171 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265019172 MarR family; Region: MarR_2; cl17246 266265019173 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266265019174 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266265019175 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 266265019176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265019177 active site 266265019178 phosphorylation site [posttranslational modification] 266265019179 intermolecular recognition site; other site 266265019180 dimerization interface [polypeptide binding]; other site 266265019181 ANTAR domain; Region: ANTAR; pfam03861 266265019182 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265019183 NMT1-like family; Region: NMT1_2; pfam13379 266265019184 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266265019185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265019186 HAMP domain; Region: HAMP; pfam00672 266265019187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265019188 dimer interface [polypeptide binding]; other site 266265019189 phosphorylation site [posttranslational modification] 266265019190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265019191 ATP binding site [chemical binding]; other site 266265019192 Mg2+ binding site [ion binding]; other site 266265019193 G-X-G motif; other site 266265019194 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266265019195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265019196 active site 266265019197 phosphorylation site [posttranslational modification] 266265019198 intermolecular recognition site; other site 266265019199 dimerization interface [polypeptide binding]; other site 266265019200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265019201 DNA binding site [nucleotide binding] 266265019202 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265019203 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265019204 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266265019205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265019206 dimer interface [polypeptide binding]; other site 266265019207 conserved gate region; other site 266265019208 ABC-ATPase subunit interface; other site 266265019209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265019210 dimer interface [polypeptide binding]; other site 266265019211 conserved gate region; other site 266265019212 putative PBP binding loops; other site 266265019213 ABC-ATPase subunit interface; other site 266265019214 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265019215 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 266265019216 Walker A/P-loop; other site 266265019217 ATP binding site [chemical binding]; other site 266265019218 Q-loop/lid; other site 266265019219 ABC transporter signature motif; other site 266265019220 Walker B; other site 266265019221 D-loop; other site 266265019222 H-loop/switch region; other site 266265019223 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265019224 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265019225 trimer interface [polypeptide binding]; other site 266265019226 eyelet of channel; other site 266265019227 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 266265019228 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 266265019229 ligand binding site [chemical binding]; other site 266265019230 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265019231 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265019232 TM-ABC transporter signature motif; other site 266265019233 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265019234 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265019235 TM-ABC transporter signature motif; other site 266265019236 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265019237 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265019238 Walker A/P-loop; other site 266265019239 ATP binding site [chemical binding]; other site 266265019240 Q-loop/lid; other site 266265019241 ABC transporter signature motif; other site 266265019242 Walker B; other site 266265019243 D-loop; other site 266265019244 H-loop/switch region; other site 266265019245 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265019246 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265019247 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266265019248 Domain of unknown function (DUF718); Region: DUF718; pfam05336 266265019249 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 266265019250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019251 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 266265019252 putative dimerization interface [polypeptide binding]; other site 266265019253 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265019254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265019255 NAD(P) binding site [chemical binding]; other site 266265019256 active site 266265019257 L-rhamnonate dehydratase; Provisional; Region: PRK15440 266265019258 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 266265019259 putative active site pocket [active] 266265019260 putative metal binding site [ion binding]; other site 266265019261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265019263 putative substrate translocation pore; other site 266265019264 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265019265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265019266 NAD(P) binding site [chemical binding]; other site 266265019267 active site 266265019268 Predicted transporter component [General function prediction only]; Region: COG2391 266265019269 Sulphur transport; Region: Sulf_transp; pfam04143 266265019270 Predicted transporter component [General function prediction only]; Region: COG2391 266265019271 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 266265019272 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266265019273 Proline racemase; Region: Pro_racemase; pfam05544 266265019274 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265019275 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 266265019276 dimerization interface [polypeptide binding]; other site 266265019277 ligand binding site [chemical binding]; other site 266265019278 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 266265019279 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 266265019280 putative acyl-acceptor binding pocket; other site 266265019281 putative arabinose transporter; Provisional; Region: PRK03545 266265019282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019283 putative substrate translocation pore; other site 266265019284 H-NS histone family; Region: Histone_HNS; pfam00816 266265019285 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266265019286 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266265019287 Low molecular weight phosphatase family; Region: LMWPc; cl00105 266265019288 active site 266265019289 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266265019290 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 266265019291 HSP70 interaction site [polypeptide binding]; other site 266265019292 Predicted flavoprotein [General function prediction only]; Region: COG0431 266265019293 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265019294 Amidase; Region: Amidase; cl11426 266265019295 indole acetimide hydrolase; Validated; Region: PRK07488 266265019296 CDP-diacylglycerol pyrophosphatase; Region: CDH; pfam02611 266265019297 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 266265019298 putative di-iron ligands [ion binding]; other site 266265019299 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266265019300 CoA binding domain; Region: CoA_binding_2; pfam13380 266265019301 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266265019302 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266265019303 enoyl-CoA hydratase; Provisional; Region: PRK06688 266265019304 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265019305 substrate binding site [chemical binding]; other site 266265019306 oxyanion hole (OAH) forming residues; other site 266265019307 trimer interface [polypeptide binding]; other site 266265019308 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265019309 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266265019310 NAD(P) binding site [chemical binding]; other site 266265019311 catalytic residues [active] 266265019312 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265019313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019314 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265019315 dimerization interface [polypeptide binding]; other site 266265019316 substrate binding pocket [chemical binding]; other site 266265019317 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266265019318 tricarballylate dehydrogenase; Validated; Region: PRK08274 266265019319 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 266265019320 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266265019321 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265019322 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265019323 Walker A/P-loop; other site 266265019324 ATP binding site [chemical binding]; other site 266265019325 Q-loop/lid; other site 266265019326 ABC transporter signature motif; other site 266265019327 Walker B; other site 266265019328 D-loop; other site 266265019329 H-loop/switch region; other site 266265019330 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265019331 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265019332 Walker A/P-loop; other site 266265019333 ATP binding site [chemical binding]; other site 266265019334 Q-loop/lid; other site 266265019335 ABC transporter signature motif; other site 266265019336 Walker B; other site 266265019337 D-loop; other site 266265019338 H-loop/switch region; other site 266265019339 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265019340 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265019341 TM-ABC transporter signature motif; other site 266265019342 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265019343 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265019344 TM-ABC transporter signature motif; other site 266265019345 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266265019346 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265019347 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266265019348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265019349 DNA-binding site [nucleotide binding]; DNA binding site 266265019350 UTRA domain; Region: UTRA; pfam07702 266265019351 galactonate dehydratase; Provisional; Region: PRK14017 266265019352 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 266265019353 active site pocket [active] 266265019354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019355 D-galactonate transporter; Region: 2A0114; TIGR00893 266265019356 putative substrate translocation pore; other site 266265019357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019358 D-galactonate transporter; Region: 2A0114; TIGR00893 266265019359 putative substrate translocation pore; other site 266265019360 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265019361 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266265019362 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265019363 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265019364 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266265019365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265019366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265019368 dimerization interface [polypeptide binding]; other site 266265019369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019370 putative substrate translocation pore; other site 266265019371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019372 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266265019373 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 266265019374 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 266265019375 glycerate dehydrogenase; Provisional; Region: PRK06932 266265019376 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 266265019377 putative ligand binding site [chemical binding]; other site 266265019378 putative NAD binding site [chemical binding]; other site 266265019379 catalytic site [active] 266265019380 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265019381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265019382 DNA-binding site [nucleotide binding]; DNA binding site 266265019383 FCD domain; Region: FCD; pfam07729 266265019384 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266265019385 catalytic core [active] 266265019386 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 266265019387 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266265019388 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266265019389 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 266265019390 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265019391 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265019392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019393 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265019394 putative substrate translocation pore; other site 266265019395 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266265019396 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 266265019397 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265019398 NAD binding site [chemical binding]; other site 266265019399 catalytic residues [active] 266265019400 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265019401 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265019402 NIPSNAP; Region: NIPSNAP; pfam07978 266265019403 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265019404 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265019405 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266265019406 benzoate transport; Region: 2A0115; TIGR00895 266265019407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019408 putative substrate translocation pore; other site 266265019409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019410 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 266265019411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265019412 NAD(P) binding site [chemical binding]; other site 266265019413 active site 266265019414 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265019415 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265019416 DNA binding site [nucleotide binding] 266265019417 domain linker motif; other site 266265019418 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 266265019419 putative dimerization interface [polypeptide binding]; other site 266265019420 putative ligand binding site [chemical binding]; other site 266265019421 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266265019422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265019423 dimerization interface [polypeptide binding]; other site 266265019424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265019425 PAS domain; Region: PAS_9; pfam13426 266265019426 putative active site [active] 266265019427 heme pocket [chemical binding]; other site 266265019428 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265019429 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265019430 metal binding site [ion binding]; metal-binding site 266265019431 active site 266265019432 I-site; other site 266265019433 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265019434 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266265019435 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 266265019436 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 266265019437 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266265019438 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266265019439 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266265019440 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266265019441 carboxyltransferase (CT) interaction site; other site 266265019442 biotinylation site [posttranslational modification]; other site 266265019443 enoyl-CoA hydratase; Provisional; Region: PRK05995 266265019444 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265019445 substrate binding site [chemical binding]; other site 266265019446 oxyanion hole (OAH) forming residues; other site 266265019447 trimer interface [polypeptide binding]; other site 266265019448 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 266265019449 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266265019450 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 266265019451 isovaleryl-CoA dehydrogenase; Region: PLN02519 266265019452 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 266265019453 substrate binding site [chemical binding]; other site 266265019454 FAD binding site [chemical binding]; other site 266265019455 catalytic base [active] 266265019456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265019457 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265019458 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 266265019459 Protein of unknown function DUF72; Region: DUF72; pfam01904 266265019460 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 266265019461 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 266265019462 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 266265019463 IHF dimer interface [polypeptide binding]; other site 266265019464 IHF - DNA interface [nucleotide binding]; other site 266265019465 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 266265019466 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265019467 metal binding site [ion binding]; metal-binding site 266265019468 active site 266265019469 I-site; other site 266265019470 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265019471 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 266265019472 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265019473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019474 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265019475 dimerization interface [polypeptide binding]; other site 266265019476 substrate binding pocket [chemical binding]; other site 266265019477 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266265019478 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 266265019479 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266265019480 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266265019481 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266265019482 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266265019483 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 266265019484 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266265019485 active site residue [active] 266265019486 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265019487 MarR family; Region: MarR_2; pfam12802 266265019488 putative MFS family transporter protein; Provisional; Region: PRK03633 266265019489 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 266265019490 agmatinase; Region: agmatinase; TIGR01230 266265019491 oligomer interface [polypeptide binding]; other site 266265019492 putative active site [active] 266265019493 Mn binding site [ion binding]; other site 266265019494 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 266265019495 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 266265019496 NAD(P) binding site [chemical binding]; other site 266265019497 catalytic residues [active] 266265019498 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266265019499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265019500 non-specific DNA binding site [nucleotide binding]; other site 266265019501 salt bridge; other site 266265019502 sequence-specific DNA binding site [nucleotide binding]; other site 266265019503 Cupin domain; Region: Cupin_2; pfam07883 266265019504 Peptidase C26; Region: Peptidase_C26; pfam07722 266265019505 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 266265019506 catalytic triad [active] 266265019507 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 266265019508 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 266265019509 putative aminotransferase; Validated; Region: PRK07480 266265019510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265019511 inhibitor-cofactor binding pocket; inhibition site 266265019512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265019513 catalytic residue [active] 266265019514 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 266265019515 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 266265019516 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 266265019517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265019518 Walker A/P-loop; other site 266265019519 ATP binding site [chemical binding]; other site 266265019520 Q-loop/lid; other site 266265019521 ABC transporter signature motif; other site 266265019522 Walker B; other site 266265019523 D-loop; other site 266265019524 H-loop/switch region; other site 266265019525 TOBE domain; Region: TOBE_2; pfam08402 266265019526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265019527 dimer interface [polypeptide binding]; other site 266265019528 conserved gate region; other site 266265019529 putative PBP binding loops; other site 266265019530 ABC-ATPase subunit interface; other site 266265019531 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265019532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265019533 dimer interface [polypeptide binding]; other site 266265019534 conserved gate region; other site 266265019535 putative PBP binding loops; other site 266265019536 ABC-ATPase subunit interface; other site 266265019537 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 266265019538 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 266265019539 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265019540 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265019541 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265019542 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265019543 Protein of unknown function (DUF969); Region: DUF969; pfam06149 266265019544 Predicted membrane protein [Function unknown]; Region: COG3817 266265019545 Protein of unknown function (DUF979); Region: DUF979; pfam06166 266265019546 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 266265019547 PRC-barrel domain; Region: PRC; pfam05239 266265019548 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 266265019549 DNA polymerase II; Reviewed; Region: PRK05762 266265019550 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 266265019551 active site 266265019552 catalytic site [active] 266265019553 substrate binding site [chemical binding]; other site 266265019554 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 266265019555 active site 266265019556 metal-binding site 266265019557 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 266265019558 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266265019559 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 266265019560 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265019561 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 266265019562 putative effector binding pocket; other site 266265019563 putative dimerization interface [polypeptide binding]; other site 266265019564 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266265019565 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 266265019566 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 266265019567 FAD binding pocket [chemical binding]; other site 266265019568 FAD binding motif [chemical binding]; other site 266265019569 phosphate binding motif [ion binding]; other site 266265019570 beta-alpha-beta structure motif; other site 266265019571 NAD binding pocket [chemical binding]; other site 266265019572 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265019573 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 266265019574 putative C-terminal domain interface [polypeptide binding]; other site 266265019575 putative GSH binding site (G-site) [chemical binding]; other site 266265019576 putative dimer interface [polypeptide binding]; other site 266265019577 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 266265019578 putative N-terminal domain interface [polypeptide binding]; other site 266265019579 putative dimer interface [polypeptide binding]; other site 266265019580 putative substrate binding pocket (H-site) [chemical binding]; other site 266265019581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265019582 DNA-binding site [nucleotide binding]; DNA binding site 266265019583 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265019584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265019585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265019586 homodimer interface [polypeptide binding]; other site 266265019587 catalytic residue [active] 266265019588 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 266265019589 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 266265019590 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266265019591 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 266265019592 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 266265019593 benzoate transport; Region: 2A0115; TIGR00895 266265019594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019595 putative substrate translocation pore; other site 266265019596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265019598 non-specific DNA binding site [nucleotide binding]; other site 266265019599 salt bridge; other site 266265019600 sequence-specific DNA binding site [nucleotide binding]; other site 266265019601 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266265019602 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 266265019603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019604 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 266265019605 dimerizarion interface [polypeptide binding]; other site 266265019606 CrgA pocket; other site 266265019607 substrate binding pocket [chemical binding]; other site 266265019608 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 266265019609 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 266265019610 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 266265019611 putative alpha subunit interface [polypeptide binding]; other site 266265019612 putative active site [active] 266265019613 putative substrate binding site [chemical binding]; other site 266265019614 Fe binding site [ion binding]; other site 266265019615 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265019616 inter-subunit interface; other site 266265019617 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 266265019618 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265019619 catalytic loop [active] 266265019620 iron binding site [ion binding]; other site 266265019621 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 266265019622 FAD binding pocket [chemical binding]; other site 266265019623 FAD binding motif [chemical binding]; other site 266265019624 phosphate binding motif [ion binding]; other site 266265019625 beta-alpha-beta structure motif; other site 266265019626 NAD binding pocket [chemical binding]; other site 266265019627 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 266265019628 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 266265019629 putative NAD(P) binding site [chemical binding]; other site 266265019630 active site 266265019631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265019632 binding surface 266265019633 TPR motif; other site 266265019634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265019635 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265019636 TPR motif; other site 266265019637 binding surface 266265019638 TPR repeat; Region: TPR_11; pfam13414 266265019639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265019640 binding surface 266265019641 TPR motif; other site 266265019642 TPR repeat; Region: TPR_11; pfam13414 266265019643 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265019644 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 266265019645 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 266265019646 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265019647 N-terminal plug; other site 266265019648 ligand-binding site [chemical binding]; other site 266265019649 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 266265019650 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 266265019651 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 266265019652 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 266265019653 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 266265019654 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265019655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 266265019656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265019657 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265019658 Helix-turn-helix domain; Region: HTH_31; pfam13560 266265019659 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265019660 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 266265019661 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 266265019662 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265019663 N-terminal plug; other site 266265019664 ligand-binding site [chemical binding]; other site 266265019665 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 266265019666 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266265019667 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266265019668 Flagellar regulator YcgR; Region: YcgR; pfam07317 266265019669 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 266265019670 PilZ domain; Region: PilZ; pfam07238 266265019671 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266265019672 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266265019673 ligand binding site [chemical binding]; other site 266265019674 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265019675 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265019676 TM-ABC transporter signature motif; other site 266265019677 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265019678 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265019679 Walker A/P-loop; other site 266265019680 ATP binding site [chemical binding]; other site 266265019681 Q-loop/lid; other site 266265019682 ABC transporter signature motif; other site 266265019683 Walker B; other site 266265019684 D-loop; other site 266265019685 H-loop/switch region; other site 266265019686 MarR family; Region: MarR_2; pfam12802 266265019687 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266265019688 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 266265019689 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 266265019690 Transglycosylase; Region: Transgly; pfam00912 266265019691 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 266265019692 RNA polymerase sigma factor; Provisional; Region: PRK12514 266265019693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265019694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265019695 DNA binding residues [nucleotide binding] 266265019696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 266265019697 Anti-sigma-K factor rskA; Region: RskA; pfam10099 266265019698 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265019699 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265019700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265019701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265019702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019703 D-galactonate transporter; Region: 2A0114; TIGR00893 266265019704 putative substrate translocation pore; other site 266265019705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019706 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 266265019707 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266265019708 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266265019709 shikimate binding site; other site 266265019710 NAD(P) binding site [chemical binding]; other site 266265019711 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 266265019712 Dehydroquinase class II; Region: DHquinase_II; pfam01220 266265019713 active site 266265019714 trimer interface [polypeptide binding]; other site 266265019715 dimer interface [polypeptide binding]; other site 266265019716 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 266265019717 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 266265019718 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 266265019719 dimer interface [polypeptide binding]; other site 266265019720 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 266265019721 active site 266265019722 Fe binding site [ion binding]; other site 266265019723 PAS fold; Region: PAS_4; pfam08448 266265019724 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265019725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265019726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 266265019727 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266265019728 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265019729 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265019730 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 266265019731 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 266265019732 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 266265019733 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 266265019734 inhibitor site; inhibition site 266265019735 active site 266265019736 dimer interface [polypeptide binding]; other site 266265019737 catalytic residue [active] 266265019738 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265019739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265019740 active site 266265019741 phosphorylation site [posttranslational modification] 266265019742 intermolecular recognition site; other site 266265019743 dimerization interface [polypeptide binding]; other site 266265019744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265019745 DNA binding site [nucleotide binding] 266265019746 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265019747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265019748 putative substrate translocation pore; other site 266265019749 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 266265019750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265019751 putative DNA binding site [nucleotide binding]; other site 266265019752 putative Zn2+ binding site [ion binding]; other site 266265019753 AsnC family; Region: AsnC_trans_reg; pfam01037 266265019754 Predicted membrane protein [Function unknown]; Region: COG2259 266265019755 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 266265019756 dimer interface [polypeptide binding]; other site 266265019757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265019758 metal binding site [ion binding]; metal-binding site 266265019759 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 266265019760 SnoaL-like domain; Region: SnoaL_2; pfam12680 266265019761 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 266265019762 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 266265019763 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265019764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265019765 non-specific DNA binding site [nucleotide binding]; other site 266265019766 salt bridge; other site 266265019767 sequence-specific DNA binding site [nucleotide binding]; other site 266265019768 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266265019769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265019770 Coenzyme A binding pocket [chemical binding]; other site 266265019771 transcriptional activator FlhD; Provisional; Region: PRK02909 266265019772 transcriptional activator FlhC; Provisional; Region: PRK12860 266265019773 manganese transport protein MntH; Reviewed; Region: PRK00701 266265019774 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266265019775 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266265019776 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266265019777 Flavin binding site [chemical binding]; other site 266265019778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265019779 ABC-ATPase subunit interface; other site 266265019780 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 266265019781 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 266265019782 Walker A/P-loop; other site 266265019783 ATP binding site [chemical binding]; other site 266265019784 Q-loop/lid; other site 266265019785 ABC transporter signature motif; other site 266265019786 Walker B; other site 266265019787 D-loop; other site 266265019788 H-loop/switch region; other site 266265019789 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 266265019790 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266265019791 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266265019792 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265019793 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 266265019794 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265019795 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265019796 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265019797 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 266265019798 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265019799 substrate binding pocket [chemical binding]; other site 266265019800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265019801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019802 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266265019803 putative effector binding pocket; other site 266265019804 putative dimerization interface [polypeptide binding]; other site 266265019805 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265019806 Purine nucleoside permease (NUP); Region: NUP; pfam06516 266265019807 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265019808 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265019809 active site 266265019810 catalytic tetrad [active] 266265019811 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 266265019812 Cation efflux family; Region: Cation_efflux; pfam01545 266265019813 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 266265019814 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 266265019815 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 266265019816 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 266265019817 putative active site [active] 266265019818 Zn binding site [ion binding]; other site 266265019819 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 266265019820 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 266265019821 Walker A/P-loop; other site 266265019822 ATP binding site [chemical binding]; other site 266265019823 Q-loop/lid; other site 266265019824 ABC transporter signature motif; other site 266265019825 Walker B; other site 266265019826 D-loop; other site 266265019827 H-loop/switch region; other site 266265019828 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 266265019829 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 266265019830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265019831 dimer interface [polypeptide binding]; other site 266265019832 conserved gate region; other site 266265019833 ABC-ATPase subunit interface; other site 266265019834 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 266265019835 EamA-like transporter family; Region: EamA; cl17759 266265019836 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265019837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265019838 DNA-binding site [nucleotide binding]; DNA binding site 266265019839 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265019840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265019841 homodimer interface [polypeptide binding]; other site 266265019842 catalytic residue [active] 266265019843 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 266265019844 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265019845 inhibitor-cofactor binding pocket; inhibition site 266265019846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265019847 catalytic residue [active] 266265019848 succinic semialdehyde dehydrogenase; Region: PLN02278 266265019849 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266265019850 tetramerization interface [polypeptide binding]; other site 266265019851 NAD(P) binding site [chemical binding]; other site 266265019852 catalytic residues [active] 266265019853 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265019854 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266265019855 putative NAD(P) binding site [chemical binding]; other site 266265019856 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266265019857 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265019858 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265019859 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 266265019860 conserved cys residue [active] 266265019861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265019862 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 266265019863 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 266265019864 Uncharacterized conserved protein [Function unknown]; Region: COG3246 266265019865 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 266265019866 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265019867 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265019868 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266265019869 active site 266265019870 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265019871 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265019872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265019873 active site 266265019874 phosphorylation site [posttranslational modification] 266265019875 intermolecular recognition site; other site 266265019876 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 266265019877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265019878 motif II; other site 266265019879 methionine sulfoxide reductase A; Provisional; Region: PRK13014 266265019880 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 266265019881 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 266265019882 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 266265019883 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266265019884 catalytic residues [active] 266265019885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265019886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265019887 active site 266265019888 phosphorylation site [posttranslational modification] 266265019889 intermolecular recognition site; other site 266265019890 dimerization interface [polypeptide binding]; other site 266265019891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265019892 DNA binding site [nucleotide binding] 266265019893 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266265019894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265019895 dimerization interface [polypeptide binding]; other site 266265019896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265019897 dimer interface [polypeptide binding]; other site 266265019898 phosphorylation site [posttranslational modification] 266265019899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265019900 ATP binding site [chemical binding]; other site 266265019901 Mg2+ binding site [ion binding]; other site 266265019902 G-X-G motif; other site 266265019903 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265019904 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265019905 trimer interface [polypeptide binding]; other site 266265019906 eyelet of channel; other site 266265019907 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265019908 tellurium resistance terB-like protein; Region: terB_like; cl11965 266265019909 metal binding site [ion binding]; metal-binding site 266265019910 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 266265019911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265019913 dimerization interface [polypeptide binding]; other site 266265019914 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 266265019915 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 266265019916 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 266265019917 hypothetical protein; Provisional; Region: PRK09040 266265019918 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265019919 ligand binding site [chemical binding]; other site 266265019920 Domain of unknown function (DUF802); Region: DUF802; pfam05650 266265019921 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 266265019922 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 266265019923 NmrA-like family; Region: NmrA; pfam05368 266265019924 NAD(P) binding site [chemical binding]; other site 266265019925 active site lysine 266265019926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265019927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019928 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 266265019929 putative effector binding pocket; other site 266265019930 putative dimerization interface [polypeptide binding]; other site 266265019931 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265019932 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 266265019933 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265019934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265019935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019936 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 266265019937 putative effector binding pocket; other site 266265019938 putative dimerization interface [polypeptide binding]; other site 266265019939 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265019940 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265019941 active site 266265019942 catalytic tetrad [active] 266265019943 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265019944 metal binding site [ion binding]; metal-binding site 266265019945 active site 266265019946 I-site; other site 266265019947 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265019948 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266265019949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265019950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265019951 dimerization interface [polypeptide binding]; other site 266265019952 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 266265019953 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265019954 N-terminal plug; other site 266265019955 ligand-binding site [chemical binding]; other site 266265019956 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 266265019957 Sel1-like repeats; Region: SEL1; smart00671 266265019958 Sel1-like repeats; Region: SEL1; smart00671 266265019959 Sel1-like repeats; Region: SEL1; smart00671 266265019960 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 266265019961 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 266265019962 Na binding site [ion binding]; other site 266265019963 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 266265019964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 266265019965 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 266265019966 Histidine kinase; Region: HisKA_3; pfam07730 266265019967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265019968 ATP binding site [chemical binding]; other site 266265019969 Mg2+ binding site [ion binding]; other site 266265019970 G-X-G motif; other site 266265019971 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265019972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265019973 active site 266265019974 phosphorylation site [posttranslational modification] 266265019975 intermolecular recognition site; other site 266265019976 dimerization interface [polypeptide binding]; other site 266265019977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265019978 DNA binding residues [nucleotide binding] 266265019979 dimerization interface [polypeptide binding]; other site 266265019980 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 266265019981 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 266265019982 putative active site [active] 266265019983 catalytic site [active] 266265019984 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 266265019985 putative active site [active] 266265019986 catalytic site [active] 266265019987 H-NS histone family; Region: Histone_HNS; pfam00816 266265019988 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266265019989 H-NS histone family; Region: Histone_HNS; pfam00816 266265019990 Protein of unknown function, DUF488; Region: DUF488; pfam04343 266265019991 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 266265019992 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 266265019993 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 266265019994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265019995 ATP binding site [chemical binding]; other site 266265019996 putative Mg++ binding site [ion binding]; other site 266265019997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265019998 nucleotide binding region [chemical binding]; other site 266265019999 ATP-binding site [chemical binding]; other site 266265020000 DEAD/H associated; Region: DEAD_assoc; pfam08494 266265020001 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 266265020002 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 266265020003 putative active site [active] 266265020004 putative metal binding site [ion binding]; other site 266265020005 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265020006 FAD binding domain; Region: FAD_binding_4; pfam01565 266265020007 Berberine and berberine like; Region: BBE; pfam08031 266265020008 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266265020009 Cache domain; Region: Cache_2; pfam08269 266265020010 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265020011 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265020012 dimer interface [polypeptide binding]; other site 266265020013 putative CheW interface [polypeptide binding]; other site 266265020014 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 266265020015 putative deacylase active site [active] 266265020016 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266265020017 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265020018 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265020019 trimer interface [polypeptide binding]; other site 266265020020 eyelet of channel; other site 266265020021 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 266265020022 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 266265020023 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266265020024 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266265020025 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266265020026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 266265020027 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 266265020028 Uncharacterized conserved protein [Function unknown]; Region: COG2308 266265020029 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 266265020030 IHF dimer interface [polypeptide binding]; other site 266265020031 IHF - DNA interface [nucleotide binding]; other site 266265020032 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265020033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265020034 DNA-binding site [nucleotide binding]; DNA binding site 266265020035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265020036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265020037 homodimer interface [polypeptide binding]; other site 266265020038 catalytic residue [active] 266265020039 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 266265020040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020041 putative substrate translocation pore; other site 266265020042 POT family; Region: PTR2; cl17359 266265020043 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266265020044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265020045 non-specific DNA binding site [nucleotide binding]; other site 266265020046 salt bridge; other site 266265020047 sequence-specific DNA binding site [nucleotide binding]; other site 266265020048 Cupin domain; Region: Cupin_2; pfam07883 266265020049 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 266265020050 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 266265020051 peptide binding site [polypeptide binding]; other site 266265020052 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 266265020053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265020054 dimer interface [polypeptide binding]; other site 266265020055 conserved gate region; other site 266265020056 putative PBP binding loops; other site 266265020057 ABC-ATPase subunit interface; other site 266265020058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266265020059 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 266265020060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265020061 dimer interface [polypeptide binding]; other site 266265020062 conserved gate region; other site 266265020063 putative PBP binding loops; other site 266265020064 ABC-ATPase subunit interface; other site 266265020065 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266265020066 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265020067 Walker A/P-loop; other site 266265020068 ATP binding site [chemical binding]; other site 266265020069 Q-loop/lid; other site 266265020070 ABC transporter signature motif; other site 266265020071 Walker B; other site 266265020072 D-loop; other site 266265020073 H-loop/switch region; other site 266265020074 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265020075 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 266265020076 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265020077 Walker A/P-loop; other site 266265020078 ATP binding site [chemical binding]; other site 266265020079 Q-loop/lid; other site 266265020080 ABC transporter signature motif; other site 266265020081 Walker B; other site 266265020082 D-loop; other site 266265020083 H-loop/switch region; other site 266265020084 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265020085 Slx4 endonuclease; Region: Slx4; pfam09494 266265020086 outer membrane porin, OprD family; Region: OprD; pfam03573 266265020087 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265020088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265020089 putative DNA binding site [nucleotide binding]; other site 266265020090 putative Zn2+ binding site [ion binding]; other site 266265020091 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265020092 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265020093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265020094 Walker A/P-loop; other site 266265020095 ATP binding site [chemical binding]; other site 266265020096 Q-loop/lid; other site 266265020097 ABC transporter signature motif; other site 266265020098 Walker B; other site 266265020099 D-loop; other site 266265020100 H-loop/switch region; other site 266265020101 TOBE domain; Region: TOBE_2; pfam08402 266265020102 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 266265020103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265020104 dimer interface [polypeptide binding]; other site 266265020105 conserved gate region; other site 266265020106 putative PBP binding loops; other site 266265020107 ABC-ATPase subunit interface; other site 266265020108 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265020109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265020110 dimer interface [polypeptide binding]; other site 266265020111 conserved gate region; other site 266265020112 putative PBP binding loops; other site 266265020113 ABC-ATPase subunit interface; other site 266265020114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 266265020115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265020116 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266265020117 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265020118 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265020119 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265020120 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265020121 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 266265020122 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 266265020123 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 266265020124 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 266265020125 active site 266265020126 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 266265020127 active site 266265020128 catalytic motif [active] 266265020129 Zn binding site [ion binding]; other site 266265020130 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 266265020131 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 266265020132 Nucleoside recognition; Region: Gate; pfam07670 266265020133 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 266265020134 putative acyltransferase; Provisional; Region: PRK05790 266265020135 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265020136 dimer interface [polypeptide binding]; other site 266265020137 active site 266265020138 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265020139 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265020140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020141 putative substrate translocation pore; other site 266265020142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020143 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 266265020144 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265020145 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265020146 Transcriptional regulators [Transcription]; Region: MarR; COG1846 266265020147 MarR family; Region: MarR_2; pfam12802 266265020148 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265020149 MarR family; Region: MarR_2; cl17246 266265020150 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 266265020151 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 266265020152 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 266265020153 putative active site [active] 266265020154 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266265020155 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 266265020156 Walker A/P-loop; other site 266265020157 ATP binding site [chemical binding]; other site 266265020158 Q-loop/lid; other site 266265020159 ABC transporter signature motif; other site 266265020160 Walker B; other site 266265020161 D-loop; other site 266265020162 H-loop/switch region; other site 266265020163 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266265020164 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265020165 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 266265020166 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266265020167 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266265020168 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266265020169 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266265020170 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266265020171 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 266265020172 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 266265020173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 266265020174 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 266265020175 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 266265020176 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 266265020177 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 266265020178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 266265020179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 266265020180 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 266265020181 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 266265020182 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 266265020183 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 266265020184 Phasin protein; Region: Phasin_2; pfam09361 266265020185 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 266265020186 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 266265020187 RibD C-terminal domain; Region: RibD_C; cl17279 266265020188 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266265020189 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266265020190 active site 266265020191 FMN binding site [chemical binding]; other site 266265020192 substrate binding site [chemical binding]; other site 266265020193 homotetramer interface [polypeptide binding]; other site 266265020194 catalytic residue [active] 266265020195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265020196 dimerization interface [polypeptide binding]; other site 266265020197 putative DNA binding site [nucleotide binding]; other site 266265020198 putative Zn2+ binding site [ion binding]; other site 266265020199 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265020200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265020201 active site 266265020202 phosphorylation site [posttranslational modification] 266265020203 intermolecular recognition site; other site 266265020204 dimerization interface [polypeptide binding]; other site 266265020205 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265020206 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265020207 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266265020208 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265020209 dimerization interface [polypeptide binding]; other site 266265020210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265020211 dimer interface [polypeptide binding]; other site 266265020212 phosphorylation site [posttranslational modification] 266265020213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265020214 ATP binding site [chemical binding]; other site 266265020215 Mg2+ binding site [ion binding]; other site 266265020216 G-X-G motif; other site 266265020217 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266265020218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265020219 active site 266265020220 phosphorylation site [posttranslational modification] 266265020221 intermolecular recognition site; other site 266265020222 dimerization interface [polypeptide binding]; other site 266265020223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265020224 DNA binding site [nucleotide binding] 266265020225 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 266265020226 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 266265020227 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 266265020228 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265020229 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 266265020230 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265020231 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265020232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020233 D-galactonate transporter; Region: 2A0114; TIGR00893 266265020234 putative substrate translocation pore; other site 266265020235 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265020236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265020237 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 266265020238 acyl-activating enzyme (AAE) consensus motif; other site 266265020239 putative AMP binding site [chemical binding]; other site 266265020240 putative active site [active] 266265020241 putative CoA binding site [chemical binding]; other site 266265020242 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266265020243 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 266265020244 putative catalytic cysteine [active] 266265020245 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265020246 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265020247 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265020248 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265020249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020250 putative substrate translocation pore; other site 266265020251 choline dehydrogenase; Validated; Region: PRK02106 266265020252 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265020253 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265020254 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265020255 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265020256 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265020257 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265020258 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265020259 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265020260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265020261 DNA-binding site [nucleotide binding]; DNA binding site 266265020262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265020263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265020264 homodimer interface [polypeptide binding]; other site 266265020265 catalytic residue [active] 266265020266 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 266265020267 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265020268 substrate binding pocket [chemical binding]; other site 266265020269 membrane-bound complex binding site; other site 266265020270 hinge residues; other site 266265020271 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 266265020272 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265020273 Walker A/P-loop; other site 266265020274 ATP binding site [chemical binding]; other site 266265020275 Q-loop/lid; other site 266265020276 ABC transporter signature motif; other site 266265020277 Walker B; other site 266265020278 D-loop; other site 266265020279 H-loop/switch region; other site 266265020280 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265020281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265020282 ABC-ATPase subunit interface; other site 266265020283 putative PBP binding loops; other site 266265020284 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 266265020285 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265020286 PYR/PP interface [polypeptide binding]; other site 266265020287 dimer interface [polypeptide binding]; other site 266265020288 TPP binding site [chemical binding]; other site 266265020289 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265020290 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 266265020291 TPP-binding site; other site 266265020292 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 266265020293 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 266265020294 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 266265020295 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 266265020296 metal ion-dependent adhesion site (MIDAS); other site 266265020297 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 266265020298 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 266265020299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 266265020300 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 266265020301 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265020302 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265020303 SnoaL-like domain; Region: SnoaL_2; pfam12680 266265020304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265020305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265020306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265020307 dimerization interface [polypeptide binding]; other site 266265020308 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265020309 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265020310 catalytic site [active] 266265020311 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265020312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265020313 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 266265020314 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 266265020315 N- and C-terminal domain interface [polypeptide binding]; other site 266265020316 active site 266265020317 MgATP binding site [chemical binding]; other site 266265020318 catalytic site [active] 266265020319 metal binding site [ion binding]; metal-binding site 266265020320 carbohydrate binding site [chemical binding]; other site 266265020321 putative homodimer interface [polypeptide binding]; other site 266265020322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265020323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265020324 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265020325 putative effector binding pocket; other site 266265020326 dimerization interface [polypeptide binding]; other site 266265020327 Cupin domain; Region: Cupin_2; cl17218 266265020328 Cupin domain; Region: Cupin_2; cl17218 266265020329 PAS fold; Region: PAS_4; pfam08448 266265020330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 266265020331 putative active site [active] 266265020332 heme pocket [chemical binding]; other site 266265020333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265020334 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 266265020335 Walker A motif; other site 266265020336 ATP binding site [chemical binding]; other site 266265020337 Walker B motif; other site 266265020338 arginine finger; other site 266265020339 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 266265020340 Putative phosphatase (DUF442); Region: DUF442; cl17385 266265020341 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266265020342 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266265020343 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265020344 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265020345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265020346 DNA-binding site [nucleotide binding]; DNA binding site 266265020347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265020348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265020349 homodimer interface [polypeptide binding]; other site 266265020350 catalytic residue [active] 266265020351 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 266265020352 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265020353 inhibitor-cofactor binding pocket; inhibition site 266265020354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265020355 catalytic residue [active] 266265020356 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 266265020357 Protein of unknown function (DUF796); Region: DUF796; pfam05638 266265020358 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265020359 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 266265020360 putative ligand binding site [chemical binding]; other site 266265020361 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265020362 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265020363 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265020364 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265020365 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265020366 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265020367 Cytochrome c; Region: Cytochrom_C; pfam00034 266265020368 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 266265020369 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265020370 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 266265020371 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265020372 Amidohydrolase; Region: Amidohydro_5; pfam13594 266265020373 Amidohydrolase; Region: Amidohydro_4; pfam13147 266265020374 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 266265020375 active site 266265020376 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265020377 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265020378 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265020379 Walker A/P-loop; other site 266265020380 ATP binding site [chemical binding]; other site 266265020381 Q-loop/lid; other site 266265020382 ABC transporter signature motif; other site 266265020383 Walker B; other site 266265020384 D-loop; other site 266265020385 H-loop/switch region; other site 266265020386 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265020387 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265020388 Walker A/P-loop; other site 266265020389 ATP binding site [chemical binding]; other site 266265020390 Q-loop/lid; other site 266265020391 ABC transporter signature motif; other site 266265020392 Walker B; other site 266265020393 D-loop; other site 266265020394 H-loop/switch region; other site 266265020395 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265020396 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265020397 TM-ABC transporter signature motif; other site 266265020398 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265020399 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265020400 TM-ABC transporter signature motif; other site 266265020401 Amino acid synthesis; Region: AA_synth; pfam06684 266265020402 Amino acid synthesis; Region: AA_synth; pfam06684 266265020403 hypothetical protein; Provisional; Region: PRK04334 266265020404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265020405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265020406 Methyltransferase domain; Region: Methyltransf_31; pfam13847 266265020407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265020408 S-adenosylmethionine binding site [chemical binding]; other site 266265020409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 266265020410 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 266265020411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265020412 putative homodimer interface [polypeptide binding]; other site 266265020413 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266265020414 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 266265020415 Probable Catalytic site; other site 266265020416 metal-binding site 266265020417 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 266265020418 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 266265020419 Walker A/P-loop; other site 266265020420 ATP binding site [chemical binding]; other site 266265020421 Q-loop/lid; other site 266265020422 ABC transporter signature motif; other site 266265020423 Walker B; other site 266265020424 D-loop; other site 266265020425 H-loop/switch region; other site 266265020426 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 266265020427 putative carbohydrate binding site [chemical binding]; other site 266265020428 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 266265020429 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 266265020430 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265020431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265020432 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 266265020433 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 266265020434 active site 266265020435 homodimer interface [polypeptide binding]; other site 266265020436 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 266265020437 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266265020438 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 266265020439 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 266265020440 tetramer interface [polypeptide binding]; other site 266265020441 active site 266265020442 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 266265020443 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 266265020444 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265020445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265020446 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 266265020447 substrate binding pocket [chemical binding]; other site 266265020448 dimerization interface [polypeptide binding]; other site 266265020449 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 266265020450 GTP cyclohydrolase I; Provisional; Region: PLN03044 266265020451 active site 266265020452 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266265020453 EamA-like transporter family; Region: EamA; pfam00892 266265020454 EamA-like transporter family; Region: EamA; pfam00892 266265020455 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 266265020456 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 266265020457 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265020458 active site residue [active] 266265020459 Cache domain; Region: Cache_1; pfam02743 266265020460 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265020461 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265020462 metal binding site [ion binding]; metal-binding site 266265020463 active site 266265020464 I-site; other site 266265020465 CHAD domain; Region: CHAD; pfam05235 266265020466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265020467 Transposase; Region: HTH_Tnp_1; pfam01527 266265020468 putative transposase OrfB; Reviewed; Region: PHA02517 266265020469 HTH-like domain; Region: HTH_21; pfam13276 266265020470 Integrase core domain; Region: rve; pfam00665 266265020471 Integrase core domain; Region: rve_3; pfam13683 266265020472 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 266265020473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265020474 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 266265020475 active site 266265020476 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266265020477 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 266265020478 protein binding site [polypeptide binding]; other site 266265020479 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 266265020480 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 266265020481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020482 putative transporter; Provisional; Region: PRK10504 266265020483 putative substrate translocation pore; other site 266265020484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020485 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 266265020486 active site 266265020487 metal-binding site 266265020488 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 266265020489 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 266265020490 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 266265020491 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 266265020492 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 266265020493 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265020494 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265020495 trimer interface [polypeptide binding]; other site 266265020496 eyelet of channel; other site 266265020497 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 266265020498 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265020499 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265020500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265020501 serine O-acetyltransferase; Region: cysE; TIGR01172 266265020502 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266265020503 trimer interface [polypeptide binding]; other site 266265020504 active site 266265020505 substrate binding site [chemical binding]; other site 266265020506 CoA binding site [chemical binding]; other site 266265020507 Transcriptional activator HlyU; Region: HlyU; cl02273 266265020508 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 266265020509 short chain dehydrogenase; Provisional; Region: PRK12827 266265020510 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 266265020511 putative NAD(P) binding site [chemical binding]; other site 266265020512 homodimer interface [polypeptide binding]; other site 266265020513 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266265020514 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266265020515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265020516 DNA binding residues [nucleotide binding] 266265020517 dimerization interface [polypeptide binding]; other site 266265020518 Autoinducer synthetase; Region: Autoind_synth; cl17404 266265020519 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 266265020520 Ligand Binding Site [chemical binding]; other site 266265020521 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 266265020522 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265020523 ligand binding site [chemical binding]; other site 266265020524 flexible hinge region; other site 266265020525 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266265020526 putative switch regulator; other site 266265020527 non-specific DNA interactions [nucleotide binding]; other site 266265020528 DNA binding site [nucleotide binding] 266265020529 sequence specific DNA binding site [nucleotide binding]; other site 266265020530 putative cAMP binding site [chemical binding]; other site 266265020531 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 266265020532 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266265020533 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 266265020534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265020535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265020536 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 266265020537 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 266265020538 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 266265020539 putative active site [active] 266265020540 putative catalytic site [active] 266265020541 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265020542 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265020543 substrate binding pocket [chemical binding]; other site 266265020544 membrane-bound complex binding site; other site 266265020545 hinge residues; other site 266265020546 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265020547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265020548 dimer interface [polypeptide binding]; other site 266265020549 conserved gate region; other site 266265020550 putative PBP binding loops; other site 266265020551 ABC-ATPase subunit interface; other site 266265020552 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265020553 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265020554 Walker A/P-loop; other site 266265020555 ATP binding site [chemical binding]; other site 266265020556 Q-loop/lid; other site 266265020557 ABC transporter signature motif; other site 266265020558 Walker B; other site 266265020559 D-loop; other site 266265020560 H-loop/switch region; other site 266265020561 hypothetical protein; Validated; Region: PRK07581 266265020562 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 266265020563 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266265020564 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265020565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265020566 DNA-binding site [nucleotide binding]; DNA binding site 266265020567 FCD domain; Region: FCD; pfam07729 266265020568 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 266265020569 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265020570 TAP-like protein; Region: Abhydrolase_4; pfam08386 266265020571 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265020572 classical (c) SDRs; Region: SDR_c; cd05233 266265020573 NAD(P) binding site [chemical binding]; other site 266265020574 active site 266265020575 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265020576 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265020577 Walker A/P-loop; other site 266265020578 ATP binding site [chemical binding]; other site 266265020579 Q-loop/lid; other site 266265020580 ABC transporter signature motif; other site 266265020581 Walker B; other site 266265020582 D-loop; other site 266265020583 H-loop/switch region; other site 266265020584 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265020585 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265020586 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265020587 TM-ABC transporter signature motif; other site 266265020588 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265020589 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265020590 TM-ABC transporter signature motif; other site 266265020591 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 266265020592 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266265020593 putative ligand binding site [chemical binding]; other site 266265020594 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266265020595 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 266265020596 active site 266265020597 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 266265020598 hypothetical protein; Provisional; Region: PRK05409 266265020599 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 266265020600 Predicted membrane protein [Function unknown]; Region: COG2259 266265020601 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265020602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265020603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265020604 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115 266265020605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265020606 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266265020607 SET domain; Region: SET; pfam00856 266265020608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265020609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265020610 WHG domain; Region: WHG; pfam13305 266265020611 Peptidase family M48; Region: Peptidase_M48; cl12018 266265020612 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 266265020613 Tetraspanin family; Region: Tetraspannin; pfam00335 266265020614 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265020615 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266265020616 substrate binding site [chemical binding]; other site 266265020617 dimer interface [polypeptide binding]; other site 266265020618 ATP binding site [chemical binding]; other site 266265020619 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265020620 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265020621 TM-ABC transporter signature motif; other site 266265020622 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265020623 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265020624 Walker A/P-loop; other site 266265020625 ATP binding site [chemical binding]; other site 266265020626 Q-loop/lid; other site 266265020627 ABC transporter signature motif; other site 266265020628 Walker B; other site 266265020629 D-loop; other site 266265020630 H-loop/switch region; other site 266265020631 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265020632 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266265020633 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266265020634 ligand binding site [chemical binding]; other site 266265020635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265020636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265020637 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266265020638 dimerization interface [polypeptide binding]; other site 266265020639 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266265020640 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 266265020641 active site 266265020642 catalytic triad [active] 266265020643 dimer interface [polypeptide binding]; other site 266265020644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265020645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265020646 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266265020647 dimerization interface [polypeptide binding]; other site 266265020648 substrate binding pocket [chemical binding]; other site 266265020649 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 266265020650 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266265020651 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266265020652 tetramer interface [polypeptide binding]; other site 266265020653 active site 266265020654 Mg2+/Mn2+ binding site [ion binding]; other site 266265020655 DNA topoisomerase I; Provisional; Region: PRK14973 266265020656 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265020657 methionine sulfoxide reductase A; Provisional; Region: PRK14054 266265020658 Predicted ester cyclase [General function prediction only]; Region: COG5485 266265020659 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 266265020660 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 266265020661 putative active site [active] 266265020662 PRC-barrel domain; Region: PRC; pfam05239 266265020663 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 266265020664 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266265020665 ligand binding site [chemical binding]; other site 266265020666 Leucine rich repeat; Region: LRR_8; pfam13855 266265020667 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 266265020668 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 266265020669 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 266265020670 active site 266265020671 ATP binding site [chemical binding]; other site 266265020672 substrate binding site [chemical binding]; other site 266265020673 activation loop (A-loop); other site 266265020674 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 266265020675 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 266265020676 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 266265020677 DNA binding site [nucleotide binding] 266265020678 active site 266265020679 allantoate amidohydrolase; Reviewed; Region: PRK12893 266265020680 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 266265020681 active site 266265020682 metal binding site [ion binding]; metal-binding site 266265020683 dimer interface [polypeptide binding]; other site 266265020684 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 266265020685 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266265020686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265020687 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 266265020688 putative dimerization interface [polypeptide binding]; other site 266265020689 putative substrate binding pocket [chemical binding]; other site 266265020690 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265020691 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266265020692 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265020693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265020694 NAD(P) binding site [chemical binding]; other site 266265020695 active site 266265020696 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266265020697 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 266265020698 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 266265020699 cyanate hydratase; Validated; Region: PRK02866 266265020700 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 266265020701 oligomer interface [polypeptide binding]; other site 266265020702 active site 266265020703 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 266265020704 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265020705 putative NAD(P) binding site [chemical binding]; other site 266265020706 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265020707 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265020708 trimer interface [polypeptide binding]; other site 266265020709 eyelet of channel; other site 266265020710 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 266265020711 PQQ-like domain; Region: PQQ_2; pfam13360 266265020712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265020714 putative substrate translocation pore; other site 266265020715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020716 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 266265020717 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 266265020718 active site 266265020719 tetramer interface [polypeptide binding]; other site 266265020720 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 266265020721 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 266265020722 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265020723 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265020724 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 266265020725 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 266265020726 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266265020727 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265020728 N-terminal plug; other site 266265020729 ligand-binding site [chemical binding]; other site 266265020730 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265020731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265020732 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 266265020733 putative effector binding pocket; other site 266265020734 putative dimerization interface [polypeptide binding]; other site 266265020735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265020736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265020737 putative substrate translocation pore; other site 266265020738 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 266265020739 catalytic site [active] 266265020740 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 266265020741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265020742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265020743 Condensation domain; Region: Condensation; pfam00668 266265020744 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 266265020745 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 266265020746 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 266265020747 acyl-activating enzyme (AAE) consensus motif; other site 266265020748 AMP binding site [chemical binding]; other site 266265020749 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266265020750 Condensation domain; Region: Condensation; pfam00668 266265020751 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 266265020752 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 266265020753 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 266265020754 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 266265020755 acyl-activating enzyme (AAE) consensus motif; other site 266265020756 AMP binding site [chemical binding]; other site 266265020757 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266265020758 Condensation domain; Region: Condensation; pfam00668 266265020759 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 266265020760 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 266265020761 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 266265020762 acyl-activating enzyme (AAE) consensus motif; other site 266265020763 AMP binding site [chemical binding]; other site 266265020764 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266265020765 Condensation domain; Region: Condensation; pfam00668 266265020766 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 266265020767 Condensation domain; Region: Condensation; pfam00668 266265020768 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 266265020769 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 266265020770 acyl-activating enzyme (AAE) consensus motif; other site 266265020771 AMP binding site [chemical binding]; other site 266265020772 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266265020773 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 266265020774 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 266265020775 Walker A/P-loop; other site 266265020776 ATP binding site [chemical binding]; other site 266265020777 Q-loop/lid; other site 266265020778 ABC transporter signature motif; other site 266265020779 Walker B; other site 266265020780 D-loop; other site 266265020781 H-loop/switch region; other site 266265020782 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 266265020783 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 266265020784 siderophore binding site; other site 266265020785 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 266265020786 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 266265020787 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 266265020788 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 266265020789 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 266265020790 ABC-ATPase subunit interface; other site 266265020791 dimer interface [polypeptide binding]; other site 266265020792 putative PBP binding regions; other site 266265020793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 266265020794 ABC-ATPase subunit interface; other site 266265020795 dimer interface [polypeptide binding]; other site 266265020796 putative PBP binding regions; other site 266265020797 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 266265020798 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 266265020799 Walker A/P-loop; other site 266265020800 ATP binding site [chemical binding]; other site 266265020801 Q-loop/lid; other site 266265020802 ABC transporter signature motif; other site 266265020803 Walker B; other site 266265020804 D-loop; other site 266265020805 H-loop/switch region; other site 266265020806 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 266265020807 MbtH-like protein; Region: MbtH; cl01279 266265020808 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 266265020809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265020810 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 266265020811 DNA binding residues [nucleotide binding] 266265020812 Phospholipid methyltransferase; Region: PEMT; cl17370 266265020813 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 266265020814 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266265020815 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266265020816 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266265020817 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 266265020818 SLBB domain; Region: SLBB; pfam10531 266265020819 SLBB domain; Region: SLBB; pfam10531 266265020820 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 266265020821 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266265020822 active site 266265020823 tyrosine kinase; Provisional; Region: PRK11519 266265020824 Chain length determinant protein; Region: Wzz; pfam02706 266265020825 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266265020826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265020827 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 266265020828 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266265020829 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 266265020830 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265020831 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 266265020832 putative ADP-binding pocket [chemical binding]; other site 266265020833 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 266265020834 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 266265020835 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265020836 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 266265020837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265020838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265020839 dimer interface [polypeptide binding]; other site 266265020840 phosphorylation site [posttranslational modification] 266265020841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265020842 ATP binding site [chemical binding]; other site 266265020843 Mg2+ binding site [ion binding]; other site 266265020844 G-X-G motif; other site 266265020845 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 266265020846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265020847 active site 266265020848 phosphorylation site [posttranslational modification] 266265020849 intermolecular recognition site; other site 266265020850 dimerization interface [polypeptide binding]; other site 266265020851 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265020852 DNA binding site [nucleotide binding] 266265020853 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265020854 NMT1/THI5 like; Region: NMT1; pfam09084 266265020855 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265020856 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265020857 Walker A/P-loop; other site 266265020858 ATP binding site [chemical binding]; other site 266265020859 Q-loop/lid; other site 266265020860 ABC transporter signature motif; other site 266265020861 Walker B; other site 266265020862 D-loop; other site 266265020863 H-loop/switch region; other site 266265020864 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265020865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265020866 dimer interface [polypeptide binding]; other site 266265020867 conserved gate region; other site 266265020868 putative PBP binding loops; other site 266265020869 ABC-ATPase subunit interface; other site 266265020870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265020871 binding surface 266265020872 TPR motif; other site 266265020873 TPR repeat; Region: TPR_11; pfam13414 266265020874 TPR repeat; Region: TPR_11; pfam13414 266265020875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 266265020876 binding surface 266265020877 TPR motif; other site 266265020878 Tetratricopeptide repeat; Region: TPR_16; pfam13432 266265020879 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 266265020880 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 266265020881 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265020882 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 266265020883 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266265020884 active site lid residues [active] 266265020885 substrate binding pocket [chemical binding]; other site 266265020886 catalytic residues [active] 266265020887 substrate-Mg2+ binding site; other site 266265020888 aspartate-rich region 1; other site 266265020889 aspartate-rich region 2; other site 266265020890 circadian clock protein KaiC; Reviewed; Region: PRK09302 266265020891 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265020892 ATP binding site [chemical binding]; other site 266265020893 Walker A motif; other site 266265020894 Walker B motif; other site 266265020895 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265020896 Walker A motif; other site 266265020897 ATP binding site [chemical binding]; other site 266265020898 Walker B motif; other site 266265020899 Response regulator receiver domain; Region: Response_reg; pfam00072 266265020900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265020901 active site 266265020902 phosphorylation site [posttranslational modification] 266265020903 intermolecular recognition site; other site 266265020904 dimerization interface [polypeptide binding]; other site 266265020905 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 266265020906 gating phenylalanine in ion channel; other site 266265020907 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265020908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265020909 The C-terminal substrate-binding domain of LysR-type trnascriptional regulator BlaA which involved in control of the beta-lactamase gene expression; contains the type 2 periplasmic binding fold; Region: PBP2_BlaA; cd08487 266265020910 putative dimerization interface [polypeptide binding]; other site 266265020911 putative substrate binding pocket [chemical binding]; other site 266265020912 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 266265020913 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 266265020914 Protein phosphatase 2C; Region: PP2C; pfam00481 266265020915 active site 266265020916 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 266265020917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265020918 Walker A motif; other site 266265020919 ATP binding site [chemical binding]; other site 266265020920 Walker B motif; other site 266265020921 arginine finger; other site 266265020922 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265020923 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265020924 ligand binding site [chemical binding]; other site 266265020925 flexible hinge region; other site 266265020926 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265020927 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265020928 ligand binding site [chemical binding]; other site 266265020929 flexible hinge region; other site 266265020930 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 266265020931 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 266265020932 putative active site [active] 266265020933 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266265020934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265020935 Walker A/P-loop; other site 266265020936 ATP binding site [chemical binding]; other site 266265020937 Q-loop/lid; other site 266265020938 ABC transporter signature motif; other site 266265020939 Walker B; other site 266265020940 D-loop; other site 266265020941 H-loop/switch region; other site 266265020942 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 266265020943 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 266265020944 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266265020945 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265020946 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265020947 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 266265020948 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266265020949 phosphopeptide binding site; other site 266265020950 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 266265020951 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 266265020952 phosphopeptide binding site; other site 266265020953 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265020954 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 266265020955 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 266265020956 Caspase domain; Region: Peptidase_C14; pfam00656 266265020957 substrate pocket [chemical binding]; other site 266265020958 active site 266265020959 dimer interface [polypeptide binding]; other site 266265020960 proteolytic cleavage site; other site 266265020961 Uncharacterized conserved protein [Function unknown]; Region: COG1262 266265020962 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 266265020963 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266265020964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266265020965 active site 266265020966 ATP binding site [chemical binding]; other site 266265020967 substrate binding site [chemical binding]; other site 266265020968 activation loop (A-loop); other site 266265020969 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 266265020970 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266265020971 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266265020972 tetramer interface [polypeptide binding]; other site 266265020973 active site 266265020974 Mg2+/Mn2+ binding site [ion binding]; other site 266265020975 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 266265020976 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 266265020977 substrate binding site [chemical binding]; other site 266265020978 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 266265020979 substrate binding site [chemical binding]; other site 266265020980 ligand binding site [chemical binding]; other site 266265020981 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266265020982 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266265020983 tetramer interface [polypeptide binding]; other site 266265020984 active site 266265020985 Mg2+/Mn2+ binding site [ion binding]; other site 266265020986 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265020987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265020988 dimer interface [polypeptide binding]; other site 266265020989 conserved gate region; other site 266265020990 putative PBP binding loops; other site 266265020991 ABC-ATPase subunit interface; other site 266265020992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265020993 dimer interface [polypeptide binding]; other site 266265020994 conserved gate region; other site 266265020995 putative PBP binding loops; other site 266265020996 ABC-ATPase subunit interface; other site 266265020997 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265020998 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265020999 Walker A/P-loop; other site 266265021000 ATP binding site [chemical binding]; other site 266265021001 Q-loop/lid; other site 266265021002 ABC transporter signature motif; other site 266265021003 Walker B; other site 266265021004 D-loop; other site 266265021005 H-loop/switch region; other site 266265021006 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265021007 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265021008 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265021009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265021010 DNA-binding site [nucleotide binding]; DNA binding site 266265021011 FCD domain; Region: FCD; pfam07729 266265021012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265021013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265021014 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 266265021015 putative dimerization interface [polypeptide binding]; other site 266265021016 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 266265021017 catalytic residues [active] 266265021018 DinB superfamily; Region: DinB_2; pfam12867 266265021019 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265021020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265021021 DNA-binding site [nucleotide binding]; DNA binding site 266265021022 FCD domain; Region: FCD; pfam07729 266265021023 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 266265021024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265021025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265021026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265021027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265021028 putative substrate translocation pore; other site 266265021029 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 266265021030 glucose-1-dehydrogenase; Provisional; Region: PRK08936 266265021031 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 266265021032 NAD binding site [chemical binding]; other site 266265021033 homodimer interface [polypeptide binding]; other site 266265021034 active site 266265021035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 266265021036 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 266265021037 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 266265021038 dimer interface [polypeptide binding]; other site 266265021039 active site 266265021040 catalytic residue [active] 266265021041 metal binding site [ion binding]; metal-binding site 266265021042 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 266265021043 dimer interface [polypeptide binding]; other site 266265021044 substrate binding site [chemical binding]; other site 266265021045 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265021046 metal binding site [ion binding]; metal-binding site 266265021047 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 266265021048 DctM-like transporters; Region: DctM; pfam06808 266265021049 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 266265021050 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 266265021051 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 266265021052 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266265021053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265021054 DNA binding site [nucleotide binding] 266265021055 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 266265021056 putative ligand binding site [chemical binding]; other site 266265021057 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265021058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265021059 putative DNA binding site [nucleotide binding]; other site 266265021060 putative Zn2+ binding site [ion binding]; other site 266265021061 AsnC family; Region: AsnC_trans_reg; pfam01037 266265021062 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 266265021063 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 266265021064 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 266265021065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265021066 D-galactonate transporter; Region: 2A0114; TIGR00893 266265021067 putative substrate translocation pore; other site 266265021068 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 266265021069 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 266265021070 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265021071 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265021072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266265021073 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265021074 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265021075 Fic/DOC family; Region: Fic; pfam02661 266265021076 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 266265021077 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265021078 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266265021079 putative active site [active] 266265021080 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 266265021081 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266265021082 Walker A/P-loop; other site 266265021083 ATP binding site [chemical binding]; other site 266265021084 Q-loop/lid; other site 266265021085 ABC transporter signature motif; other site 266265021086 Walker B; other site 266265021087 D-loop; other site 266265021088 H-loop/switch region; other site 266265021089 TOBE domain; Region: TOBE_2; pfam08402 266265021090 short chain dehydrogenase; Provisional; Region: PRK07074 266265021091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265021092 NAD(P) binding site [chemical binding]; other site 266265021093 active site 266265021094 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266265021095 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265021096 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265021097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265021098 dimer interface [polypeptide binding]; other site 266265021099 conserved gate region; other site 266265021100 putative PBP binding loops; other site 266265021101 ABC-ATPase subunit interface; other site 266265021102 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266265021103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265021104 dimer interface [polypeptide binding]; other site 266265021105 conserved gate region; other site 266265021106 putative PBP binding loops; other site 266265021107 ABC-ATPase subunit interface; other site 266265021108 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 266265021109 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 266265021110 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 266265021111 catalytic residues [active] 266265021112 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265021113 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265021114 trimer interface [polypeptide binding]; other site 266265021115 eyelet of channel; other site 266265021116 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 266265021117 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 266265021118 active site 266265021119 metal binding site [ion binding]; metal-binding site 266265021120 2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding; Region: PLN02980 266265021121 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265021122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265021123 metal binding site [ion binding]; metal-binding site 266265021124 active site 266265021125 I-site; other site 266265021126 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265021127 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 266265021128 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 266265021129 active site 266265021130 HIGH motif; other site 266265021131 dimer interface [polypeptide binding]; other site 266265021132 KMSKS motif; other site 266265021133 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 266265021134 Fe-S cluster binding site [ion binding]; other site 266265021135 active site 266265021136 Uncharacterized conserved protein [Function unknown]; Region: COG3791 266265021137 Cupin; Region: Cupin_6; pfam12852 266265021138 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265021139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265021140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265021141 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266265021142 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265021143 NADP binding site [chemical binding]; other site 266265021144 active site 266265021145 steroid binding site; other site 266265021146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265021147 C factor cell-cell signaling protein; Provisional; Region: PRK09009 266265021148 NAD(P) binding site [chemical binding]; other site 266265021149 active site 266265021150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265021151 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 266265021152 putative substrate binding pocket [chemical binding]; other site 266265021153 putative dimerization interface [polypeptide binding]; other site 266265021154 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265021155 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 266265021156 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 266265021157 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 266265021158 Fusaric acid resistance protein family; Region: FUSC; pfam04632 266265021159 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 266265021160 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265021161 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266265021162 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266265021163 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266265021164 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266265021165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265021166 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266265021167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265021168 DNA binding residues [nucleotide binding] 266265021169 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265021170 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265021171 trimer interface [polypeptide binding]; other site 266265021172 eyelet of channel; other site 266265021173 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 266265021174 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265021175 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265021176 trimer interface [polypeptide binding]; other site 266265021177 eyelet of channel; other site 266265021178 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 266265021179 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 266265021180 putative active site [active] 266265021181 YdjC motif; other site 266265021182 Mg binding site [ion binding]; other site 266265021183 putative homodimer interface [polypeptide binding]; other site 266265021184 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 266265021185 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 266265021186 B12 binding site [chemical binding]; other site 266265021187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265021188 FeS/SAM binding site; other site 266265021189 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 266265021190 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 266265021191 ligand binding site; other site 266265021192 BON domain; Region: BON; pfam04972 266265021193 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266265021194 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265021195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265021196 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 266265021197 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 266265021198 dimer interface [polypeptide binding]; other site 266265021199 acyl-activating enzyme (AAE) consensus motif; other site 266265021200 putative active site [active] 266265021201 AMP binding site [chemical binding]; other site 266265021202 putative CoA binding site [chemical binding]; other site 266265021203 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 266265021204 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 266265021205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265021206 active site 266265021207 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 266265021208 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 266265021209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265021210 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 266265021211 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 266265021212 beta-ketothiolase; Provisional; Region: PRK09051 266265021213 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265021214 dimer interface [polypeptide binding]; other site 266265021215 active site 266265021216 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 266265021217 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265021218 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265021219 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265021220 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265021221 trimer interface [polypeptide binding]; other site 266265021222 eyelet of channel; other site 266265021223 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 266265021224 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 266265021225 active site 266265021226 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266265021227 dimer interface [polypeptide binding]; other site 266265021228 substrate binding site [chemical binding]; other site 266265021229 catalytic residues [active] 266265021230 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266265021231 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266265021232 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266265021233 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266265021234 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266265021235 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265021236 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265021237 trimer interface [polypeptide binding]; other site 266265021238 eyelet of channel; other site 266265021239 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265021240 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266265021241 Walker A/P-loop; other site 266265021242 ATP binding site [chemical binding]; other site 266265021243 Q-loop/lid; other site 266265021244 ABC transporter signature motif; other site 266265021245 Walker B; other site 266265021246 D-loop; other site 266265021247 H-loop/switch region; other site 266265021248 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266265021249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265021250 Walker A/P-loop; other site 266265021251 ATP binding site [chemical binding]; other site 266265021252 Q-loop/lid; other site 266265021253 ABC transporter signature motif; other site 266265021254 Walker B; other site 266265021255 D-loop; other site 266265021256 H-loop/switch region; other site 266265021257 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265021258 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266265021259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265021260 dimer interface [polypeptide binding]; other site 266265021261 conserved gate region; other site 266265021262 putative PBP binding loops; other site 266265021263 ABC-ATPase subunit interface; other site 266265021264 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 266265021265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265021266 dimer interface [polypeptide binding]; other site 266265021267 conserved gate region; other site 266265021268 putative PBP binding loops; other site 266265021269 ABC-ATPase subunit interface; other site 266265021270 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265021271 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 266265021272 Isochorismatase family; Region: Isochorismatase; pfam00857 266265021273 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266265021274 catalytic triad [active] 266265021275 conserved cis-peptide bond; other site 266265021276 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265021277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265021278 DNA binding site [nucleotide binding] 266265021279 domain linker motif; other site 266265021280 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281 266265021281 putative dimerization interface [polypeptide binding]; other site 266265021282 putative ligand binding site [chemical binding]; other site 266265021283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265021284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265021285 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 266265021286 putative substrate binding pocket [chemical binding]; other site 266265021287 dimerization interface [polypeptide binding]; other site 266265021288 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13029 266265021289 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266265021290 dimer interface [polypeptide binding]; other site 266265021291 PYR/PP interface [polypeptide binding]; other site 266265021292 TPP binding site [chemical binding]; other site 266265021293 substrate binding site [chemical binding]; other site 266265021294 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266265021295 TPP-binding site [chemical binding]; other site 266265021296 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 266265021297 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 266265021298 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 266265021299 homodimer interface [polypeptide binding]; other site 266265021300 substrate-cofactor binding pocket; other site 266265021301 catalytic residue [active] 266265021302 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 266265021303 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 266265021304 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266265021305 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266265021306 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 266265021307 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 266265021308 dimer interaction site [polypeptide binding]; other site 266265021309 substrate-binding tunnel; other site 266265021310 active site 266265021311 catalytic site [active] 266265021312 substrate binding site [chemical binding]; other site 266265021313 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 266265021314 acetate kinase; Provisional; Region: PRK07058 266265021315 propionate/acetate kinase; Provisional; Region: PRK12379 266265021316 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 266265021317 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 266265021318 NAD binding site [chemical binding]; other site 266265021319 homotetramer interface [polypeptide binding]; other site 266265021320 homodimer interface [polypeptide binding]; other site 266265021321 substrate binding site [chemical binding]; other site 266265021322 active site 266265021323 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 266265021324 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 266265021325 NAD(P) binding site [chemical binding]; other site 266265021326 homotetramer interface [polypeptide binding]; other site 266265021327 homodimer interface [polypeptide binding]; other site 266265021328 active site 266265021329 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 266265021330 BON domain; Region: BON; pfam04972 266265021331 BON domain; Region: BON; pfam04972 266265021332 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265021333 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 266265021334 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 266265021335 Phosphoesterase family; Region: Phosphoesterase; pfam04185 266265021336 Spore Coat Protein U domain; Region: SCPU; pfam05229 266265021337 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 266265021338 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266265021339 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266265021340 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266265021341 Spore Coat Protein U domain; Region: SCPU; pfam05229 266265021342 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 266265021343 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 266265021344 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 266265021345 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 266265021346 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 266265021347 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 266265021348 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 266265021349 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265021350 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 266265021351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265021352 DNA binding residues [nucleotide binding] 266265021353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265021354 S-adenosylmethionine binding site [chemical binding]; other site 266265021355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265021356 S-adenosylmethionine binding site [chemical binding]; other site 266265021357 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 266265021358 regulatory protein interface [polypeptide binding]; other site 266265021359 regulatory phosphorylation site [posttranslational modification]; other site 266265021360 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 266265021361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265021362 hydrogenase 4 subunit B; Validated; Region: PRK06521 266265021363 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266265021364 NADH dehydrogenase; Region: NADHdh; cl00469 266265021365 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 266265021366 hydrogenase 4 subunit F; Validated; Region: PRK06458 266265021367 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266265021368 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 266265021369 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 266265021370 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 266265021371 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 266265021372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265021373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265021374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265021375 dimerization interface [polypeptide binding]; other site 266265021376 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266265021377 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265021378 motif II; other site 266265021379 hypothetical protein; Provisional; Region: PRK06486 266265021380 intersubunit interface [polypeptide binding]; other site 266265021381 active site 266265021382 Zn2+ binding site [ion binding]; other site 266265021383 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265021384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265021385 active site 266265021386 phosphorylation site [posttranslational modification] 266265021387 intermolecular recognition site; other site 266265021388 dimerization interface [polypeptide binding]; other site 266265021389 Phasin protein; Region: Phasin_2; pfam09361 266265021390 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 266265021391 dimanganese center [ion binding]; other site 266265021392 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 266265021393 putative hydrophobic ligand binding site [chemical binding]; other site 266265021394 lipoyl synthase; Provisional; Region: PRK12928 266265021395 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 266265021396 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265021397 E3 interaction surface; other site 266265021398 lipoyl attachment site [posttranslational modification]; other site 266265021399 Putative serine esterase (DUF676); Region: DUF676; pfam05057 266265021400 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265021401 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266265021402 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266265021403 alpha subunit interface [polypeptide binding]; other site 266265021404 TPP binding site [chemical binding]; other site 266265021405 heterodimer interface [polypeptide binding]; other site 266265021406 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266265021407 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 266265021408 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266265021409 tetramer interface [polypeptide binding]; other site 266265021410 TPP-binding site [chemical binding]; other site 266265021411 heterodimer interface [polypeptide binding]; other site 266265021412 phosphorylation loop region [posttranslational modification] 266265021413 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 266265021414 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 266265021415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265021416 Walker A motif; other site 266265021417 ATP binding site [chemical binding]; other site 266265021418 Walker B motif; other site 266265021419 arginine finger; other site 266265021420 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265021421 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 266265021422 GAF domain; Region: GAF; pfam01590 266265021423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265021424 Walker A motif; other site 266265021425 ATP binding site [chemical binding]; other site 266265021426 Walker B motif; other site 266265021427 arginine finger; other site 266265021428 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 266265021429 coenzyme PQQ biosynthesis protein PqqD; Region: PQQ_PqqD; TIGR03859 266265021430 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265021431 membrane-bound complex binding site; other site 266265021432 hinge residues; other site 266265021433 Cytochrome c; Region: Cytochrom_C; pfam00034 266265021434 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 266265021435 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 266265021436 dimer interface [polypeptide binding]; other site 266265021437 Trp docking motif [polypeptide binding]; other site 266265021438 active site 266265021439 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 266265021440 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265021441 NAD(P) binding site [chemical binding]; other site 266265021442 catalytic residues [active] 266265021443 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265021444 dimerization interface [polypeptide binding]; other site 266265021445 putative DNA binding site [nucleotide binding]; other site 266265021446 putative Zn2+ binding site [ion binding]; other site 266265021447 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 266265021448 arsenical-resistance protein; Region: acr3; TIGR00832 266265021449 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266265021450 ArsC family; Region: ArsC; pfam03960 266265021451 catalytic residues [active] 266265021452 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 266265021453 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265021454 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 266265021455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265021456 Walker A/P-loop; other site 266265021457 ATP binding site [chemical binding]; other site 266265021458 Q-loop/lid; other site 266265021459 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265021460 ABC transporter; Region: ABC_tran_2; pfam12848 266265021461 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 266265021462 RloB-like protein; Region: RloB; pfam13707 266265021463 AAA domain; Region: AAA_21; pfam13304 266265021464 Methyltransferase domain; Region: Methyltransf_23; pfam13489 266265021465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 266265021466 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266265021467 MULE transposase domain; Region: MULE; pfam10551 266265021468 PAS domain S-box; Region: sensory_box; TIGR00229 266265021469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265021470 putative active site [active] 266265021471 heme pocket [chemical binding]; other site 266265021472 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265021473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265021474 metal binding site [ion binding]; metal-binding site 266265021475 active site 266265021476 I-site; other site 266265021477 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 266265021478 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 266265021479 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 266265021480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265021481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265021482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265021483 dimerization interface [polypeptide binding]; other site 266265021484 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265021485 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265021486 metal binding site [ion binding]; metal-binding site 266265021487 active site 266265021488 I-site; other site 266265021489 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265021490 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 266265021491 NADP binding site [chemical binding]; other site 266265021492 dimer interface [polypeptide binding]; other site 266265021493 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266265021494 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265021495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265021496 DNA-binding site [nucleotide binding]; DNA binding site 266265021497 FCD domain; Region: FCD; pfam07729 266265021498 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266265021499 benzoate transport; Region: 2A0115; TIGR00895 266265021500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265021501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265021502 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 266265021503 tricarballylate dehydrogenase; Validated; Region: PRK08274 266265021504 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266265021505 Predicted oxidoreductase [General function prediction only]; Region: COG3573 266265021506 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 266265021507 hypothetical protein; Provisional; Region: PRK07236 266265021508 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266265021509 active site 266265021510 FMN binding site [chemical binding]; other site 266265021511 substrate binding site [chemical binding]; other site 266265021512 homotetramer interface [polypeptide binding]; other site 266265021513 catalytic residue [active] 266265021514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265021515 classical (c) SDRs; Region: SDR_c; cd05233 266265021516 NAD(P) binding site [chemical binding]; other site 266265021517 active site 266265021518 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265021519 MarR family; Region: MarR; pfam01047 266265021520 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265021521 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265021522 substrate binding site [chemical binding]; other site 266265021523 oxyanion hole (OAH) forming residues; other site 266265021524 trimer interface [polypeptide binding]; other site 266265021525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265021526 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266265021527 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265021528 active site 266265021529 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 266265021530 active site 266265021531 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 266265021532 homotrimer interaction site [polypeptide binding]; other site 266265021533 putative active site [active] 266265021534 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265021535 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 266265021536 acyl-activating enzyme (AAE) consensus motif; other site 266265021537 AMP binding site [chemical binding]; other site 266265021538 active site 266265021539 CoA binding site [chemical binding]; other site 266265021540 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 266265021541 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265021542 SnoaL-like domain; Region: SnoaL_2; pfam12680 266265021543 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 266265021544 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 266265021545 putative C-terminal domain interface [polypeptide binding]; other site 266265021546 putative GSH binding site (G-site) [chemical binding]; other site 266265021547 putative dimer interface [polypeptide binding]; other site 266265021548 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 266265021549 putative N-terminal domain interface [polypeptide binding]; other site 266265021550 putative dimer interface [polypeptide binding]; other site 266265021551 putative substrate binding pocket (H-site) [chemical binding]; other site 266265021552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265021553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265021554 putative substrate translocation pore; other site 266265021555 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 266265021556 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 266265021557 active site 266265021558 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265021559 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265021560 active site 266265021561 non-prolyl cis peptide bond; other site 266265021562 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265021563 TAP-like protein; Region: Abhydrolase_4; pfam08386 266265021564 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 266265021565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265021566 NAD(P) binding site [chemical binding]; other site 266265021567 active site 266265021568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265021569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265021570 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265021571 putative effector binding pocket; other site 266265021572 dimerization interface [polypeptide binding]; other site 266265021573 short chain dehydrogenase; Provisional; Region: PRK06172 266265021574 classical (c) SDRs; Region: SDR_c; cd05233 266265021575 NAD(P) binding site [chemical binding]; other site 266265021576 active site 266265021577 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 266265021578 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 266265021579 active site 266265021580 FMN binding site [chemical binding]; other site 266265021581 substrate binding site [chemical binding]; other site 266265021582 homotetramer interface [polypeptide binding]; other site 266265021583 catalytic residue [active] 266265021584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265021585 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265021586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265021587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 266265021588 Uncharacterized conserved protein [Function unknown]; Region: COG3586 266265021589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265021590 AAA domain; Region: AAA_23; pfam13476 266265021591 Walker A/P-loop; other site 266265021592 ATP binding site [chemical binding]; other site 266265021593 WYL domain; Region: WYL; pfam13280 266265021594 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 266265021595 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265021596 catalytic residue [active] 266265021597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265021598 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 266265021599 Coenzyme A binding pocket [chemical binding]; other site 266265021600 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 266265021601 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 266265021602 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265021603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265021604 DNA-binding site [nucleotide binding]; DNA binding site 266265021605 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265021606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265021607 homodimer interface [polypeptide binding]; other site 266265021608 catalytic residue [active] 266265021609 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266265021610 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266265021611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266265021612 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 266265021613 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 266265021614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265021615 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266265021616 dimerization interface [polypeptide binding]; other site 266265021617 substrate binding pocket [chemical binding]; other site 266265021618 Predicted permeases [General function prediction only]; Region: COG0679 266265021619 Cupin domain; Region: Cupin_2; cl17218 266265021620 Helix-turn-helix domain; Region: HTH_18; pfam12833 266265021621 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265021622 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266265021623 putative NAD(P) binding site [chemical binding]; other site 266265021624 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 266265021625 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 266265021626 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 266265021627 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265021628 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 266265021629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265021630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 266265021631 YCII-related domain; Region: YCII; cl00999 266265021632 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266265021633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266265021634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265021635 Coenzyme A binding pocket [chemical binding]; other site 266265021636 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 266265021637 High potential iron-sulfur protein; Region: HIPIP; pfam01355 266265021638 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 266265021639 putative FMN binding site [chemical binding]; other site 266265021640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265021641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265021642 dimer interface [polypeptide binding]; other site 266265021643 phosphorylation site [posttranslational modification] 266265021644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265021645 ATP binding site [chemical binding]; other site 266265021646 Mg2+ binding site [ion binding]; other site 266265021647 G-X-G motif; other site 266265021648 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 266265021649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265021650 active site 266265021651 phosphorylation site [posttranslational modification] 266265021652 intermolecular recognition site; other site 266265021653 dimerization interface [polypeptide binding]; other site 266265021654 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 266265021655 GAF domain; Region: GAF; pfam01590 266265021656 PAS domain S-box; Region: sensory_box; TIGR00229 266265021657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265021658 putative active site [active] 266265021659 heme pocket [chemical binding]; other site 266265021660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265021661 dimer interface [polypeptide binding]; other site 266265021662 phosphorylation site [posttranslational modification] 266265021663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265021664 ATP binding site [chemical binding]; other site 266265021665 Mg2+ binding site [ion binding]; other site 266265021666 G-X-G motif; other site 266265021667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265021668 active site 266265021669 phosphorylation site [posttranslational modification] 266265021670 intermolecular recognition site; other site 266265021671 dimerization interface [polypeptide binding]; other site 266265021672 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265021673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265021674 active site 266265021675 phosphorylation site [posttranslational modification] 266265021676 intermolecular recognition site; other site 266265021677 dimerization interface [polypeptide binding]; other site 266265021678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 266265021679 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 266265021680 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 266265021681 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265021682 N-terminal plug; other site 266265021683 ligand-binding site [chemical binding]; other site 266265021684 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265021685 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265021686 active site 266265021687 catalytic tetrad [active] 266265021688 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 266265021689 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 266265021690 nucleotide binding site [chemical binding]; other site 266265021691 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 266265021692 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 266265021693 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 266265021694 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 266265021695 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 266265021696 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 266265021697 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 266265021698 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 266265021699 Phosphoesterase family; Region: Phosphoesterase; pfam04185 266265021700 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266265021701 Domain of unknown function (DUF756); Region: DUF756; pfam05506 266265021702 Cupin domain; Region: Cupin_2; cl17218 266265021703 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 266265021704 Predicted deacylase [General function prediction only]; Region: COG3608 266265021705 active site 266265021706 Zn binding site [ion binding]; other site 266265021707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265021708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265021709 substrate binding pocket [chemical binding]; other site 266265021710 membrane-bound complex binding site; other site 266265021711 hinge residues; other site 266265021712 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 266265021713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265021714 LysR substrate binding domain; Region: LysR_substrate; pfam03466 266265021715 dimerization interface [polypeptide binding]; other site 266265021716 short chain dehydrogenase; Provisional; Region: PRK06180 266265021717 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265021718 NADP binding site [chemical binding]; other site 266265021719 active site 266265021720 steroid binding site; other site 266265021721 Rubredoxin; Region: Rubredoxin; pfam00301 266265021722 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 266265021723 iron binding site [ion binding]; other site 266265021724 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265021725 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265021726 [2Fe-2S] cluster binding site [ion binding]; other site 266265021727 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 266265021728 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 266265021729 DXD motif; other site 266265021730 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266265021731 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266265021732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265021733 S-adenosylmethionine binding site [chemical binding]; other site 266265021734 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 266265021735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265021736 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 266265021737 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 266265021738 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 266265021739 EamA-like transporter family; Region: EamA; pfam00892 266265021740 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 266265021741 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 266265021742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265021743 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265021744 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 266265021745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265021746 Coenzyme A binding pocket [chemical binding]; other site 266265021747 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 266265021748 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 266265021749 nucleotide binding site [chemical binding]; other site 266265021750 putative NEF/HSP70 interaction site [polypeptide binding]; other site 266265021751 SBD interface [polypeptide binding]; other site 266265021752 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 266265021753 HSP70 interaction site [polypeptide binding]; other site 266265021754 RHS Repeat; Region: RHS_repeat; pfam05593 266265021755 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 266265021756 RHS Repeat; Region: RHS_repeat; pfam05593 266265021757 RHS Repeat; Region: RHS_repeat; pfam05593 266265021758 RHS Repeat; Region: RHS_repeat; cl11982 266265021759 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 266265021760 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 266265021761 benzoate transport; Region: 2A0115; TIGR00895 266265021762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265021763 putative substrate translocation pore; other site 266265021764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265021765 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266265021766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265021767 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266265021768 active site 266265021769 metal binding site [ion binding]; metal-binding site 266265021770 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 266265021771 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265021772 putative active site [active] 266265021773 putative metal binding site [ion binding]; other site 266265021774 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265021775 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266265021776 NAD(P) binding site [chemical binding]; other site 266265021777 catalytic residues [active] 266265021778 L-aspartate dehydrogenase; Provisional; Region: PRK13303 266265021779 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 266265021780 Domain of unknown function DUF108; Region: DUF108; pfam01958 266265021781 hypothetical protein; Provisional; Region: PRK07064 266265021782 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265021783 PYR/PP interface [polypeptide binding]; other site 266265021784 dimer interface [polypeptide binding]; other site 266265021785 TPP binding site [chemical binding]; other site 266265021786 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265021787 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266265021788 TPP-binding site [chemical binding]; other site 266265021789 short chain dehydrogenase; Provisional; Region: PRK07062 266265021790 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266265021791 putative NAD(P) binding site [chemical binding]; other site 266265021792 putative active site [active] 266265021793 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265021794 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265021795 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265021796 Serine hydrolase; Region: Ser_hydrolase; cl17834 266265021797 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265021798 Cupin domain; Region: Cupin_2; pfam07883 266265021799 short chain dehydrogenase; Provisional; Region: PRK12939 266265021800 classical (c) SDRs; Region: SDR_c; cd05233 266265021801 NAD(P) binding site [chemical binding]; other site 266265021802 active site 266265021803 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265021804 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265021805 [2Fe-2S] cluster binding site [ion binding]; other site 266265021806 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266265021807 hydrophobic ligand binding site; other site 266265021808 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266265021809 [2Fe-2S] cluster binding site [ion binding]; other site 266265021810 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265021811 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265021812 trimer interface [polypeptide binding]; other site 266265021813 eyelet of channel; other site 266265021814 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265021815 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265021816 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265021817 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 266265021818 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 266265021819 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 266265021820 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265021821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265021822 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266265021823 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 266265021824 catalytic residues [active] 266265021825 catalytic nucleophile [active] 266265021826 Recombinase; Region: Recombinase; pfam07508 266265021827 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 266265021828 Helix-turn-helix domain; Region: HTH_17; pfam12728 266265021829 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 266265021830 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 266265021831 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265021832 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265021833 haemagglutination activity domain; Region: Haemagg_act; pfam05860 266265021834 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 266265021835 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 266265021836 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 266265021837 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 266265021838 haemagglutination activity domain; Region: Haemagg_act; pfam05860 266265021839 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 266265021840 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 266265021841 HNH endonuclease; Region: HNH_2; pfam13391 266265021842 H-NS histone family; Region: Histone_HNS; pfam00816 266265021843 H-NS histone family; Region: Histone_HNS; pfam00816 266265021844 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 266265021845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265021846 Walker A/P-loop; other site 266265021847 ATP binding site [chemical binding]; other site 266265021848 Walker B; other site 266265021849 H-loop/switch region; other site 266265021850 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 266265021851 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 266265021852 putative Mg++ binding site [ion binding]; other site 266265021853 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 266265021854 nucleotide binding region [chemical binding]; other site 266265021855 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 266265021856 AAA ATPase domain; Region: AAA_16; pfam13191 266265021857 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 266265021858 tellurite resistance protein terB; Region: terB; cd07176 266265021859 putative metal binding site [ion binding]; other site 266265021860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265021861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265021862 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 266265021863 substrate binding pocket [chemical binding]; other site 266265021864 dimerization interface [polypeptide binding]; other site 266265021865 benzoylformate decarboxylase; Reviewed; Region: PRK07092 266265021866 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265021867 PYR/PP interface [polypeptide binding]; other site 266265021868 dimer interface [polypeptide binding]; other site 266265021869 TPP binding site [chemical binding]; other site 266265021870 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265021871 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 266265021872 TPP-binding site [chemical binding]; other site 266265021873 dimer interface [polypeptide binding]; other site 266265021874 Mandelate dehydrogenase (MDH)-like FMN-binding domain. MDH is part of a widespread family of homologous FMN-dependent a-hydroxy acid oxidizing enzymes that oxidizes (S)-mandelate to phenylglyoxalate. MDH is an enzyme in the mandelate pathway that occurs...; Region: MDH_FMN; cd04736 266265021875 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 266265021876 active site 266265021877 substrate binding site [chemical binding]; other site 266265021878 FMN binding site [chemical binding]; other site 266265021879 catalytic residues [active] 266265021880 Mandelate racemase (MR) catalyzes the Mg2+-dependent 1,1-proton transfer reaction that interconverts the enantiomers of mandelic acid. MR is the first enzyme in the bacterial pathway that converts mandelic acid to benzoic acid and allows this pathway to...; Region: mandelate_racemase; cd03321 266265021881 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266265021882 active site 266265021883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265021884 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265021885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265021886 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265021887 Transposase; Region: HTH_Tnp_1; pfam01527 266265021888 putative transposase OrfB; Reviewed; Region: PHA02517 266265021889 HTH-like domain; Region: HTH_21; pfam13276 266265021890 Integrase core domain; Region: rve; pfam00665 266265021891 Integrase core domain; Region: rve_3; pfam13683 266265021892 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266265021893 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265021894 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265021895 dimer interface [polypeptide binding]; other site 266265021896 putative CheW interface [polypeptide binding]; other site 266265021897 transposase; Validated; Region: PRK08181 266265021898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265021899 Walker A motif; other site 266265021900 ATP binding site [chemical binding]; other site 266265021901 Walker B motif; other site 266265021902 arginine finger; other site 266265021903 Integrase core domain; Region: rve; pfam00665 266265021904 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 266265021905 PAS domain S-box; Region: sensory_box; TIGR00229 266265021906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265021907 putative active site [active] 266265021908 heme pocket [chemical binding]; other site 266265021909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265021910 putative active site [active] 266265021911 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 266265021912 anticodon binding site; other site 266265021913 Peptidase family M41; Region: Peptidase_M41; pfam01434 266265021914 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 266265021915 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 266265021916 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 266265021917 ATP binding site [chemical binding]; other site 266265021918 substrate interface [chemical binding]; other site 266265021919 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 266265021920 Catalytic domain of Protein Kinases; Region: PKc; cd00180 266265021921 active site 266265021922 ATP binding site [chemical binding]; other site 266265021923 substrate binding site [chemical binding]; other site 266265021924 activation loop (A-loop); other site 266265021925 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265021926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265021927 non-specific DNA binding site [nucleotide binding]; other site 266265021928 salt bridge; other site 266265021929 sequence-specific DNA binding site [nucleotide binding]; other site 266265021930 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265021931 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 266265021932 AsnC family; Region: AsnC_trans_reg; pfam01037 266265021933 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 266265021934 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 266265021935 dimer interface [polypeptide binding]; other site 266265021936 PYR/PP interface [polypeptide binding]; other site 266265021937 TPP binding site [chemical binding]; other site 266265021938 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265021939 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 266265021940 TPP-binding site [chemical binding]; other site 266265021941 dimer interface [polypeptide binding]; other site 266265021942 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265021943 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265021944 NAD(P) binding site [chemical binding]; other site 266265021945 catalytic residues [active] 266265021946 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266265021947 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 266265021948 phosphate binding site [ion binding]; other site 266265021949 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 266265021950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266265021951 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265021952 CCC1-related family of proteins; Region: CCC1_like; cl00278 266265021953 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 266265021954 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266265021955 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266265021956 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266265021957 Chromate transporter; Region: Chromate_transp; pfam02417 266265021958 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265021959 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 266265021960 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 266265021961 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 266265021962 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 266265021963 NADP binding site [chemical binding]; other site 266265021964 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265021965 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265021966 active site 266265021967 catalytic tetrad [active] 266265021968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265021969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265021970 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266265021971 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 266265021972 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 266265021973 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 266265021974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265021975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265021976 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 266265021977 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 266265021978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265021979 dimer interface [polypeptide binding]; other site 266265021980 conserved gate region; other site 266265021981 putative PBP binding loops; other site 266265021982 ABC-ATPase subunit interface; other site 266265021983 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 266265021984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265021985 dimer interface [polypeptide binding]; other site 266265021986 conserved gate region; other site 266265021987 putative PBP binding loops; other site 266265021988 ABC-ATPase subunit interface; other site 266265021989 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 266265021990 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 266265021991 Walker A/P-loop; other site 266265021992 ATP binding site [chemical binding]; other site 266265021993 Q-loop/lid; other site 266265021994 ABC transporter signature motif; other site 266265021995 Walker B; other site 266265021996 D-loop; other site 266265021997 H-loop/switch region; other site 266265021998 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265021999 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266265022000 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265022001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265022002 catalytic loop [active] 266265022003 iron binding site [ion binding]; other site 266265022004 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265022005 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265022006 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265022007 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265022008 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265022009 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265022010 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 266265022011 putative hydrophobic ligand binding site [chemical binding]; other site 266265022012 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265022013 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265022014 trimer interface [polypeptide binding]; other site 266265022015 eyelet of channel; other site 266265022016 NIPSNAP; Region: NIPSNAP; pfam07978 266265022017 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 266265022018 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 266265022019 metal binding site [ion binding]; metal-binding site 266265022020 putative dimer interface [polypeptide binding]; other site 266265022021 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 266265022022 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265022023 Walker A/P-loop; other site 266265022024 ATP binding site [chemical binding]; other site 266265022025 Q-loop/lid; other site 266265022026 ABC transporter signature motif; other site 266265022027 Walker B; other site 266265022028 D-loop; other site 266265022029 H-loop/switch region; other site 266265022030 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265022031 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265022032 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 266265022033 Walker A/P-loop; other site 266265022034 ATP binding site [chemical binding]; other site 266265022035 Q-loop/lid; other site 266265022036 ABC transporter signature motif; other site 266265022037 Walker B; other site 266265022038 D-loop; other site 266265022039 H-loop/switch region; other site 266265022040 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 266265022041 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 266265022042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022043 dimer interface [polypeptide binding]; other site 266265022044 conserved gate region; other site 266265022045 putative PBP binding loops; other site 266265022046 ABC-ATPase subunit interface; other site 266265022047 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266265022048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022049 dimer interface [polypeptide binding]; other site 266265022050 conserved gate region; other site 266265022051 putative PBP binding loops; other site 266265022052 ABC-ATPase subunit interface; other site 266265022053 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265022054 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 266265022055 substrate binding site [chemical binding]; other site 266265022056 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265022057 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265022058 trimer interface [polypeptide binding]; other site 266265022059 eyelet of channel; other site 266265022060 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 266265022061 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 266265022062 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 266265022063 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 266265022064 active sites [active] 266265022065 tetramer interface [polypeptide binding]; other site 266265022066 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265022067 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266265022068 FMN-binding pocket [chemical binding]; other site 266265022069 flavin binding motif; other site 266265022070 phosphate binding motif [ion binding]; other site 266265022071 beta-alpha-beta structure motif; other site 266265022072 NAD binding pocket [chemical binding]; other site 266265022073 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265022074 catalytic loop [active] 266265022075 iron binding site [ion binding]; other site 266265022076 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 266265022077 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 266265022078 conserved cys residue [active] 266265022079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265022080 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 266265022081 active site 266265022082 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265022083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265022084 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266265022085 Helix-turn-helix domain; Region: HTH_38; pfam13936 266265022086 Integrase core domain; Region: rve; pfam00665 266265022087 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265022088 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265022089 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 266265022090 putative metal binding site [ion binding]; other site 266265022091 putative homodimer interface [polypeptide binding]; other site 266265022092 putative homotetramer interface [polypeptide binding]; other site 266265022093 putative homodimer-homodimer interface [polypeptide binding]; other site 266265022094 putative allosteric switch controlling residues; other site 266265022095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265022096 sequence-specific DNA binding site [nucleotide binding]; other site 266265022097 salt bridge; other site 266265022098 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 266265022099 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265022100 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265022101 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265022102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265022103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265022104 putative substrate translocation pore; other site 266265022105 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 266265022106 homotrimer interaction site [polypeptide binding]; other site 266265022107 putative active site [active] 266265022108 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 266265022109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265022110 dimer interface [polypeptide binding]; other site 266265022111 putative metal binding site [ion binding]; other site 266265022112 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265022113 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 266265022114 nucleophilic elbow; other site 266265022115 catalytic triad; other site 266265022116 TAP-like protein; Region: Abhydrolase_4; pfam08386 266265022117 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266265022118 DNA binding site [nucleotide binding] 266265022119 active site 266265022120 Int/Topo IB signature motif; other site 266265022121 catalytic residues [active] 266265022122 Putative phage integrase; Region: Phage_Integr_2; pfam13009 266265022123 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 266265022124 active site 266265022125 Int/Topo IB signature motif; other site 266265022126 catalytic residues [active] 266265022127 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 266265022128 dihydrodipicolinate synthase; Region: dapA; TIGR00674 266265022129 dimer interface [polypeptide binding]; other site 266265022130 active site 266265022131 catalytic residue [active] 266265022132 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 266265022133 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265022134 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265022135 catalytic residue [active] 266265022136 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265022137 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265022138 ligand binding site [chemical binding]; other site 266265022139 flexible hinge region; other site 266265022140 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266265022141 putative switch regulator; other site 266265022142 non-specific DNA interactions [nucleotide binding]; other site 266265022143 DNA binding site [nucleotide binding] 266265022144 sequence specific DNA binding site [nucleotide binding]; other site 266265022145 putative cAMP binding site [chemical binding]; other site 266265022146 Predicted membrane protein [Function unknown]; Region: COG4539 266265022147 Predicted permeases [General function prediction only]; Region: RarD; COG2962 266265022148 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 266265022149 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 266265022150 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 266265022151 acylphosphatase; Provisional; Region: PRK14424 266265022152 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 266265022153 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 266265022154 putative NADP binding site [chemical binding]; other site 266265022155 putative substrate binding site [chemical binding]; other site 266265022156 active site 266265022157 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 266265022158 active site 266265022159 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 266265022160 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266265022161 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266265022162 active site lid residues [active] 266265022163 substrate binding pocket [chemical binding]; other site 266265022164 catalytic residues [active] 266265022165 substrate-Mg2+ binding site; other site 266265022166 aspartate-rich region 1; other site 266265022167 aspartate-rich region 2; other site 266265022168 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 266265022169 LytB protein; Region: LYTB; pfam02401 266265022170 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 266265022171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265022172 FeS/SAM binding site; other site 266265022173 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 266265022174 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 266265022175 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 266265022176 VacJ like lipoprotein; Region: VacJ; cl01073 266265022177 hypothetical protein; Provisional; Region: PRK07077 266265022178 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 266265022179 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 266265022180 Active site cavity [active] 266265022181 catalytic acid [active] 266265022182 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 266265022183 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 266265022184 active site lid residues [active] 266265022185 substrate binding pocket [chemical binding]; other site 266265022186 catalytic residues [active] 266265022187 substrate-Mg2+ binding site; other site 266265022188 aspartate-rich region 1; other site 266265022189 aspartate-rich region 2; other site 266265022190 PAS fold; Region: PAS; pfam00989 266265022191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265022192 putative active site [active] 266265022193 heme pocket [chemical binding]; other site 266265022194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265022195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265022196 metal binding site [ion binding]; metal-binding site 266265022197 active site 266265022198 I-site; other site 266265022199 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 266265022200 CheC-like family; Region: CheC; pfam04509 266265022201 Response regulator receiver domain; Region: Response_reg; pfam00072 266265022202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265022203 active site 266265022204 phosphorylation site [posttranslational modification] 266265022205 intermolecular recognition site; other site 266265022206 dimerization interface [polypeptide binding]; other site 266265022207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265022208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265022209 dimer interface [polypeptide binding]; other site 266265022210 phosphorylation site [posttranslational modification] 266265022211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265022212 ATP binding site [chemical binding]; other site 266265022213 Mg2+ binding site [ion binding]; other site 266265022214 G-X-G motif; other site 266265022215 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265022216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265022217 active site 266265022218 phosphorylation site [posttranslational modification] 266265022219 intermolecular recognition site; other site 266265022220 dimerization interface [polypeptide binding]; other site 266265022221 Predicted flavoprotein [General function prediction only]; Region: COG0431 266265022222 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265022223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 266265022224 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 266265022225 GntP family permease; Region: GntP_permease; pfam02447 266265022226 fructuronate transporter; Provisional; Region: PRK10034; cl15264 266265022227 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265022228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265022229 substrate binding pocket [chemical binding]; other site 266265022230 membrane-bound complex binding site; other site 266265022231 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 266265022232 ArsC family; Region: ArsC; pfam03960 266265022233 catalytic residues [active] 266265022234 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 266265022235 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 266265022236 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 266265022237 5-oxoprolinase; Region: PLN02666 266265022238 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266265022239 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266265022240 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266265022241 Protein of unknown function (DUF969); Region: DUF969; pfam06149 266265022242 Predicted membrane protein [Function unknown]; Region: COG3817 266265022243 Protein of unknown function (DUF979); Region: DUF979; pfam06166 266265022244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265022245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265022246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265022247 dimerization interface [polypeptide binding]; other site 266265022248 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265022249 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265022250 trimer interface [polypeptide binding]; other site 266265022251 eyelet of channel; other site 266265022252 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265022253 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265022254 dimer interface [polypeptide binding]; other site 266265022255 putative CheW interface [polypeptide binding]; other site 266265022256 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265022257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265022258 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265022259 dimerization interface [polypeptide binding]; other site 266265022260 substrate binding pocket [chemical binding]; other site 266265022261 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 266265022262 EamA-like transporter family; Region: EamA; cl17759 266265022263 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 266265022264 classical (c) SDRs; Region: SDR_c; cd05233 266265022265 NAD(P) binding site [chemical binding]; other site 266265022266 active site 266265022267 hypothetical protein; Provisional; Region: PRK06834 266265022268 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265022269 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 266265022270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265022271 putative active site [active] 266265022272 heme pocket [chemical binding]; other site 266265022273 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265022274 metal binding site [ion binding]; metal-binding site 266265022275 active site 266265022276 I-site; other site 266265022277 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265022278 hypothetical protein; Provisional; Region: PRK07179 266265022279 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 266265022280 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265022281 catalytic residue [active] 266265022282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265022283 active site 266265022284 phosphorylation site [posttranslational modification] 266265022285 intermolecular recognition site; other site 266265022286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265022287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265022288 dimer interface [polypeptide binding]; other site 266265022289 phosphorylation site [posttranslational modification] 266265022290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265022291 ATP binding site [chemical binding]; other site 266265022292 Mg2+ binding site [ion binding]; other site 266265022293 G-X-G motif; other site 266265022294 Transposase domain (DUF772); Region: DUF772; pfam05598 266265022295 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 266265022296 Winged helix-turn helix; Region: HTH_29; pfam13551 266265022297 Integrase core domain; Region: rve; pfam00665 266265022298 Integrase core domain; Region: rve_3; cl15866 266265022299 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 266265022300 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 266265022301 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 266265022302 PQQ-like domain; Region: PQQ_2; pfam13360 266265022303 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 266265022304 LytTr DNA-binding domain; Region: LytTR; smart00850 266265022305 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265022306 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 266265022307 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265022308 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265022309 catalytic loop [active] 266265022310 iron binding site [ion binding]; other site 266265022311 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265022312 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 266265022313 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265022314 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265022315 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 266265022316 putative hydrophobic ligand binding site [chemical binding]; other site 266265022317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265022318 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 266265022319 Walker A motif; other site 266265022320 ATP binding site [chemical binding]; other site 266265022321 Walker B motif; other site 266265022322 arginine finger; other site 266265022323 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 266265022324 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 266265022325 metal ion-dependent adhesion site (MIDAS); other site 266265022326 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 266265022327 XdhC Rossmann domain; Region: XdhC_C; pfam13478 266265022328 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 266265022329 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 266265022330 Ligand binding site; other site 266265022331 metal-binding site 266265022332 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 266265022333 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 266265022334 nickel responsive regulator; Provisional; Region: PRK02967 266265022335 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 266265022336 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 266265022337 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 266265022338 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 266265022339 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265022340 N-terminal plug; other site 266265022341 ligand-binding site [chemical binding]; other site 266265022342 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 266265022343 core domain interface [polypeptide binding]; other site 266265022344 delta subunit interface [polypeptide binding]; other site 266265022345 epsilon subunit interface [polypeptide binding]; other site 266265022346 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 266265022347 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266265022348 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265022349 Walker A motif; other site 266265022350 ATP binding site [chemical binding]; other site 266265022351 Walker B motif; other site 266265022352 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266265022353 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 266265022354 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 266265022355 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 266265022356 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 266265022357 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 266265022358 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 266265022359 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 266265022360 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 266265022361 gamma subunit interface [polypeptide binding]; other site 266265022362 epsilon subunit interface [polypeptide binding]; other site 266265022363 LBP interface [polypeptide binding]; other site 266265022364 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 266265022365 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 266265022366 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 266265022367 alpha subunit interaction interface [polypeptide binding]; other site 266265022368 Walker A motif; other site 266265022369 ATP binding site [chemical binding]; other site 266265022370 Walker B motif; other site 266265022371 inhibitor binding site; inhibition site 266265022372 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 266265022373 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 266265022374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265022375 NAD(P) binding site [chemical binding]; other site 266265022376 active site 266265022377 acetate kinase; Provisional; Region: PRK07058 266265022378 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 266265022379 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 266265022380 dimer interaction site [polypeptide binding]; other site 266265022381 substrate-binding tunnel; other site 266265022382 active site 266265022383 catalytic site [active] 266265022384 substrate binding site [chemical binding]; other site 266265022385 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 266265022386 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 266265022387 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 266265022388 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 266265022389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265022390 DNA-binding site [nucleotide binding]; DNA binding site 266265022391 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 266265022392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 266265022393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265022394 homodimer interface [polypeptide binding]; other site 266265022395 catalytic residue [active] 266265022396 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 266265022397 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 266265022398 tetramer interface [polypeptide binding]; other site 266265022399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265022400 catalytic residue [active] 266265022401 ectoine utilization protein EutC; Validated; Region: PRK08291 266265022402 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 266265022403 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 266265022404 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 266265022405 putative active site [active] 266265022406 Zn binding site [ion binding]; other site 266265022407 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 266265022408 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265022409 putative DNA binding site [nucleotide binding]; other site 266265022410 putative Zn2+ binding site [ion binding]; other site 266265022411 AsnC family; Region: AsnC_trans_reg; pfam01037 266265022412 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266265022413 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265022414 tetramerization interface [polypeptide binding]; other site 266265022415 NAD(P) binding site [chemical binding]; other site 266265022416 catalytic residues [active] 266265022417 hypothetical protein; Provisional; Region: PRK07482 266265022418 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265022419 inhibitor-cofactor binding pocket; inhibition site 266265022420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265022421 catalytic residue [active] 266265022422 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 266265022423 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265022424 putative NAD(P) binding site [chemical binding]; other site 266265022425 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 266265022426 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 266265022427 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 266265022428 active site 266265022429 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 266265022430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265022431 Walker A/P-loop; other site 266265022432 ATP binding site [chemical binding]; other site 266265022433 Q-loop/lid; other site 266265022434 ABC transporter signature motif; other site 266265022435 Walker B; other site 266265022436 D-loop; other site 266265022437 H-loop/switch region; other site 266265022438 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 266265022439 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265022440 substrate binding pocket [chemical binding]; other site 266265022441 membrane-bound complex binding site; other site 266265022442 hinge residues; other site 266265022443 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265022444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022445 dimer interface [polypeptide binding]; other site 266265022446 conserved gate region; other site 266265022447 putative PBP binding loops; other site 266265022448 ABC-ATPase subunit interface; other site 266265022449 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265022450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022451 dimer interface [polypeptide binding]; other site 266265022452 conserved gate region; other site 266265022453 putative PBP binding loops; other site 266265022454 ABC-ATPase subunit interface; other site 266265022455 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266265022456 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265022457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265022458 putative substrate translocation pore; other site 266265022459 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 266265022460 GAF domain; Region: GAF; pfam01590 266265022461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265022462 dimer interface [polypeptide binding]; other site 266265022463 phosphorylation site [posttranslational modification] 266265022464 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 266265022465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265022466 ATP binding site [chemical binding]; other site 266265022467 Mg2+ binding site [ion binding]; other site 266265022468 G-X-G motif; other site 266265022469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265022470 Response regulator receiver domain; Region: Response_reg; pfam00072 266265022471 active site 266265022472 phosphorylation site [posttranslational modification] 266265022473 intermolecular recognition site; other site 266265022474 dimerization interface [polypeptide binding]; other site 266265022475 Low affinity iron permease; Region: Iron_permease; pfam04120 266265022476 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 266265022477 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 266265022478 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 266265022479 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 266265022480 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 266265022481 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 266265022482 NAD binding site [chemical binding]; other site 266265022483 catalytic Zn binding site [ion binding]; other site 266265022484 structural Zn binding site [ion binding]; other site 266265022485 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265022486 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 266265022487 putative NAD(P) binding site [chemical binding]; other site 266265022488 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 266265022489 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266265022490 Cytochrome c; Region: Cytochrom_C; pfam00034 266265022491 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266265022492 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266265022493 D-pathway; other site 266265022494 Putative ubiquinol binding site [chemical binding]; other site 266265022495 Low-spin heme (heme b) binding site [chemical binding]; other site 266265022496 Putative water exit pathway; other site 266265022497 Binuclear center (heme o3/CuB) [ion binding]; other site 266265022498 K-pathway; other site 266265022499 Putative proton exit pathway; other site 266265022500 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 266265022501 Subunit I/III interface [polypeptide binding]; other site 266265022502 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265022503 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265022504 Cytochrome c; Region: Cytochrom_C; pfam00034 266265022505 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 266265022506 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 266265022507 putative molybdopterin cofactor binding site [chemical binding]; other site 266265022508 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 266265022509 putative molybdopterin cofactor binding site; other site 266265022510 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265022511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022512 dimer interface [polypeptide binding]; other site 266265022513 conserved gate region; other site 266265022514 putative PBP binding loops; other site 266265022515 ABC-ATPase subunit interface; other site 266265022516 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 266265022517 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265022518 Walker A/P-loop; other site 266265022519 ATP binding site [chemical binding]; other site 266265022520 Q-loop/lid; other site 266265022521 ABC transporter signature motif; other site 266265022522 Walker B; other site 266265022523 D-loop; other site 266265022524 H-loop/switch region; other site 266265022525 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 266265022526 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265022527 substrate binding pocket [chemical binding]; other site 266265022528 membrane-bound complex binding site; other site 266265022529 hinge residues; other site 266265022530 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 266265022531 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265022532 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349 266265022533 putative ligand binding site [chemical binding]; other site 266265022534 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266265022535 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266265022536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 266265022537 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266265022538 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 266265022539 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 266265022540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265022541 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265022542 dimerization interface [polypeptide binding]; other site 266265022543 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265022544 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349 266265022545 putative ligand binding site [chemical binding]; other site 266265022546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265022547 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265022548 TM-ABC transporter signature motif; other site 266265022549 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265022550 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265022551 TM-ABC transporter signature motif; other site 266265022552 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265022553 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265022554 Walker A/P-loop; other site 266265022555 ATP binding site [chemical binding]; other site 266265022556 Q-loop/lid; other site 266265022557 ABC transporter signature motif; other site 266265022558 Walker B; other site 266265022559 D-loop; other site 266265022560 H-loop/switch region; other site 266265022561 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265022562 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265022563 Walker A/P-loop; other site 266265022564 ATP binding site [chemical binding]; other site 266265022565 Q-loop/lid; other site 266265022566 ABC transporter signature motif; other site 266265022567 Walker B; other site 266265022568 D-loop; other site 266265022569 H-loop/switch region; other site 266265022570 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265022571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022572 dimer interface [polypeptide binding]; other site 266265022573 conserved gate region; other site 266265022574 putative PBP binding loops; other site 266265022575 ABC-ATPase subunit interface; other site 266265022576 NMT1-like family; Region: NMT1_2; pfam13379 266265022577 NMT1/THI5 like; Region: NMT1; pfam09084 266265022578 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265022579 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265022580 Walker A/P-loop; other site 266265022581 ATP binding site [chemical binding]; other site 266265022582 Q-loop/lid; other site 266265022583 ABC transporter signature motif; other site 266265022584 Walker B; other site 266265022585 D-loop; other site 266265022586 H-loop/switch region; other site 266265022587 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265022588 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265022589 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266265022590 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266265022591 Cupin; Region: Cupin_6; pfam12852 266265022592 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265022593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265022594 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265022595 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265022596 substrate binding pocket [chemical binding]; other site 266265022597 membrane-bound complex binding site; other site 266265022598 hinge residues; other site 266265022599 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265022600 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265022601 trimer interface [polypeptide binding]; other site 266265022602 eyelet of channel; other site 266265022603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265022604 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265022605 substrate binding pocket [chemical binding]; other site 266265022606 membrane-bound complex binding site; other site 266265022607 hinge residues; other site 266265022608 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265022609 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265022610 active site 266265022611 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 266265022612 putative FMN binding site [chemical binding]; other site 266265022613 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265022614 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266265022615 active site 266265022616 iron coordination sites [ion binding]; other site 266265022617 substrate binding pocket [chemical binding]; other site 266265022618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265022619 putative substrate translocation pore; other site 266265022620 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266265022621 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265022622 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265022623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022624 dimer interface [polypeptide binding]; other site 266265022625 ABC-ATPase subunit interface; other site 266265022626 putative PBP binding loops; other site 266265022627 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265022628 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265022629 Walker A/P-loop; other site 266265022630 ATP binding site [chemical binding]; other site 266265022631 Q-loop/lid; other site 266265022632 ABC transporter signature motif; other site 266265022633 Walker B; other site 266265022634 D-loop; other site 266265022635 H-loop/switch region; other site 266265022636 NMT1-like family; Region: NMT1_2; pfam13379 266265022637 NMT1/THI5 like; Region: NMT1; pfam09084 266265022638 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265022639 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265022640 active site 266265022641 non-prolyl cis peptide bond; other site 266265022642 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 266265022643 active site residue [active] 266265022644 serine O-acetyltransferase; Region: cysE; TIGR01172 266265022645 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 266265022646 trimer interface [polypeptide binding]; other site 266265022647 active site 266265022648 substrate binding site [chemical binding]; other site 266265022649 CoA binding site [chemical binding]; other site 266265022650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265022651 non-specific DNA binding site [nucleotide binding]; other site 266265022652 salt bridge; other site 266265022653 sequence-specific DNA binding site [nucleotide binding]; other site 266265022654 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 266265022655 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 266265022656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265022657 catalytic residue [active] 266265022658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265022659 NAD(P) binding site [chemical binding]; other site 266265022660 active site 266265022661 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265022662 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265022663 substrate binding pocket [chemical binding]; other site 266265022664 membrane-bound complex binding site; other site 266265022665 hinge residues; other site 266265022666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022667 dimer interface [polypeptide binding]; other site 266265022668 conserved gate region; other site 266265022669 putative PBP binding loops; other site 266265022670 ABC-ATPase subunit interface; other site 266265022671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022672 dimer interface [polypeptide binding]; other site 266265022673 conserved gate region; other site 266265022674 putative PBP binding loops; other site 266265022675 ABC-ATPase subunit interface; other site 266265022676 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266265022677 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266265022678 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265022679 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265022680 Walker A/P-loop; other site 266265022681 ATP binding site [chemical binding]; other site 266265022682 Q-loop/lid; other site 266265022683 ABC transporter signature motif; other site 266265022684 Walker B; other site 266265022685 D-loop; other site 266265022686 H-loop/switch region; other site 266265022687 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265022688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022689 dimer interface [polypeptide binding]; other site 266265022690 putative PBP binding loops; other site 266265022691 ABC-ATPase subunit interface; other site 266265022692 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265022693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022694 ABC-ATPase subunit interface; other site 266265022695 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265022696 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265022697 substrate binding pocket [chemical binding]; other site 266265022698 membrane-bound complex binding site; other site 266265022699 hinge residues; other site 266265022700 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 266265022701 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 266265022702 ring oligomerisation interface [polypeptide binding]; other site 266265022703 ATP/Mg binding site [chemical binding]; other site 266265022704 stacking interactions; other site 266265022705 hinge regions; other site 266265022706 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 266265022707 oligomerisation interface [polypeptide binding]; other site 266265022708 mobile loop; other site 266265022709 roof hairpin; other site 266265022710 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266265022711 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266265022712 Flavin binding site [chemical binding]; other site 266265022713 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 266265022714 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265022715 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 266265022716 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266265022717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022718 dimer interface [polypeptide binding]; other site 266265022719 conserved gate region; other site 266265022720 putative PBP binding loops; other site 266265022721 ABC-ATPase subunit interface; other site 266265022722 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266265022723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022724 dimer interface [polypeptide binding]; other site 266265022725 conserved gate region; other site 266265022726 putative PBP binding loops; other site 266265022727 ABC-ATPase subunit interface; other site 266265022728 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266265022729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265022730 Walker A/P-loop; other site 266265022731 ATP binding site [chemical binding]; other site 266265022732 Q-loop/lid; other site 266265022733 ABC transporter signature motif; other site 266265022734 Walker B; other site 266265022735 D-loop; other site 266265022736 H-loop/switch region; other site 266265022737 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265022738 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265022739 Walker A/P-loop; other site 266265022740 ATP binding site [chemical binding]; other site 266265022741 Q-loop/lid; other site 266265022742 ABC transporter signature motif; other site 266265022743 Walker B; other site 266265022744 D-loop; other site 266265022745 H-loop/switch region; other site 266265022746 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265022747 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266265022748 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266265022749 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 266265022750 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265022751 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 266265022752 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265022753 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266265022754 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266265022755 dimer interface [polypeptide binding]; other site 266265022756 active site 266265022757 non-prolyl cis peptide bond; other site 266265022758 insertion regions; other site 266265022759 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265022760 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265022761 active site 266265022762 non-prolyl cis peptide bond; other site 266265022763 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 266265022764 Moco binding site; other site 266265022765 metal coordination site [ion binding]; other site 266265022766 dimerization interface [polypeptide binding]; other site 266265022767 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265022768 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266265022769 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265022770 NMT1-like family; Region: NMT1_2; pfam13379 266265022771 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265022772 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265022773 Walker A/P-loop; other site 266265022774 ATP binding site [chemical binding]; other site 266265022775 Q-loop/lid; other site 266265022776 ABC transporter signature motif; other site 266265022777 Walker B; other site 266265022778 D-loop; other site 266265022779 H-loop/switch region; other site 266265022780 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265022781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022782 putative PBP binding loops; other site 266265022783 dimer interface [polypeptide binding]; other site 266265022784 ABC-ATPase subunit interface; other site 266265022785 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 266265022786 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 266265022787 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265022788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265022789 substrate binding pocket [chemical binding]; other site 266265022790 membrane-bound complex binding site; other site 266265022791 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265022792 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265022793 active site 266265022794 non-prolyl cis peptide bond; other site 266265022795 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265022796 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 266265022797 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 266265022798 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 266265022799 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 266265022800 homodimer interface [polypeptide binding]; other site 266265022801 NAD binding pocket [chemical binding]; other site 266265022802 ATP binding pocket [chemical binding]; other site 266265022803 Mg binding site [ion binding]; other site 266265022804 active-site loop [active] 266265022805 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 266265022806 CsbD-like; Region: CsbD; cl17424 266265022807 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 266265022808 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266265022809 NAD binding site [chemical binding]; other site 266265022810 catalytic Zn binding site [ion binding]; other site 266265022811 structural Zn binding site [ion binding]; other site 266265022812 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 266265022813 Cytochrome c; Region: Cytochrom_C; pfam00034 266265022814 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 266265022815 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 266265022816 D-pathway; other site 266265022817 Putative ubiquinol binding site [chemical binding]; other site 266265022818 Low-spin heme (heme b) binding site [chemical binding]; other site 266265022819 Putative water exit pathway; other site 266265022820 Binuclear center (heme o3/CuB) [ion binding]; other site 266265022821 K-pathway; other site 266265022822 Putative proton exit pathway; other site 266265022823 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 266265022824 Subunit I/III interface [polypeptide binding]; other site 266265022825 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 266265022826 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265022827 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 266265022828 Cytochrome c; Region: Cytochrom_C; pfam00034 266265022829 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266265022830 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266265022831 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 266265022832 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 266265022833 Trp docking motif [polypeptide binding]; other site 266265022834 putative active site [active] 266265022835 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 266265022836 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 266265022837 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 266265022838 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 266265022839 hydrogenase 4 subunit F; Validated; Region: PRK06458 266265022840 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266265022841 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 266265022842 NADH dehydrogenase; Region: NADHdh; cl00469 266265022843 hydrogenase 4 subunit B; Validated; Region: PRK06521 266265022844 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 266265022845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265022846 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 266265022847 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 266265022848 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 266265022849 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 266265022850 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 266265022851 active site 266265022852 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 266265022853 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 266265022854 Isochorismatase family; Region: Isochorismatase; pfam00857 266265022855 catalytic triad [active] 266265022856 dimer interface [polypeptide binding]; other site 266265022857 conserved cis-peptide bond; other site 266265022858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265022859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265022860 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265022861 putative effector binding pocket; other site 266265022862 dimerization interface [polypeptide binding]; other site 266265022863 Predicted membrane protein [Function unknown]; Region: COG2259 266265022864 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 266265022865 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 266265022866 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266265022867 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265022868 Walker A/P-loop; other site 266265022869 ATP binding site [chemical binding]; other site 266265022870 Q-loop/lid; other site 266265022871 ABC transporter signature motif; other site 266265022872 Walker B; other site 266265022873 D-loop; other site 266265022874 H-loop/switch region; other site 266265022875 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 266265022876 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265022877 Walker A/P-loop; other site 266265022878 ATP binding site [chemical binding]; other site 266265022879 Q-loop/lid; other site 266265022880 ABC transporter signature motif; other site 266265022881 Walker B; other site 266265022882 D-loop; other site 266265022883 H-loop/switch region; other site 266265022884 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265022885 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266265022886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022887 dimer interface [polypeptide binding]; other site 266265022888 conserved gate region; other site 266265022889 putative PBP binding loops; other site 266265022890 ABC-ATPase subunit interface; other site 266265022891 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266265022892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022893 dimer interface [polypeptide binding]; other site 266265022894 conserved gate region; other site 266265022895 putative PBP binding loops; other site 266265022896 ABC-ATPase subunit interface; other site 266265022897 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 266265022898 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265022899 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 266265022900 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266265022901 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 266265022902 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265022903 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265022904 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265022905 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265022906 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265022907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265022908 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265022909 putative substrate translocation pore; other site 266265022910 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266265022911 active site 266265022912 catalytic site [active] 266265022913 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265022914 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265022915 active site 266265022916 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266265022917 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265022918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265022919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265022920 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 266265022921 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265022922 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266265022923 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265022924 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 266265022925 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 266265022926 Isochorismatase family; Region: Isochorismatase; pfam00857 266265022927 catalytic triad [active] 266265022928 substrate binding site [chemical binding]; other site 266265022929 domain interfaces; other site 266265022930 conserved cis-peptide bond; other site 266265022931 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265022932 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265022933 trimer interface [polypeptide binding]; other site 266265022934 eyelet of channel; other site 266265022935 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265022936 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 266265022937 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265022938 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265022939 TM-ABC transporter signature motif; other site 266265022940 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265022941 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265022942 TM-ABC transporter signature motif; other site 266265022943 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265022944 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265022945 Walker A/P-loop; other site 266265022946 ATP binding site [chemical binding]; other site 266265022947 Q-loop/lid; other site 266265022948 ABC transporter signature motif; other site 266265022949 Walker B; other site 266265022950 D-loop; other site 266265022951 H-loop/switch region; other site 266265022952 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265022953 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265022954 Walker A/P-loop; other site 266265022955 ATP binding site [chemical binding]; other site 266265022956 Q-loop/lid; other site 266265022957 ABC transporter signature motif; other site 266265022958 Walker B; other site 266265022959 D-loop; other site 266265022960 H-loop/switch region; other site 266265022961 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265022962 TolR protein; Region: tolR; TIGR02801 266265022963 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 266265022964 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266265022965 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266265022966 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 266265022967 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 266265022968 phosphate binding site [ion binding]; other site 266265022969 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 266265022970 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266265022971 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265022972 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 266265022973 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265022974 N-terminal plug; other site 266265022975 ligand-binding site [chemical binding]; other site 266265022976 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265022977 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265022978 active site 266265022979 non-prolyl cis peptide bond; other site 266265022980 hypothetical protein; Provisional; Region: PRK06208 266265022981 intersubunit interface [polypeptide binding]; other site 266265022982 active site 266265022983 Zn2+ binding site [ion binding]; other site 266265022984 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265022985 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265022986 Cupin domain; Region: Cupin_2; cl17218 266265022987 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265022988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265022989 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265022990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022991 putative PBP binding loops; other site 266265022992 dimer interface [polypeptide binding]; other site 266265022993 ABC-ATPase subunit interface; other site 266265022994 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265022995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265022996 dimer interface [polypeptide binding]; other site 266265022997 conserved gate region; other site 266265022998 putative PBP binding loops; other site 266265022999 ABC-ATPase subunit interface; other site 266265023000 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265023001 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265023002 Walker A/P-loop; other site 266265023003 ATP binding site [chemical binding]; other site 266265023004 Q-loop/lid; other site 266265023005 ABC transporter signature motif; other site 266265023006 Walker B; other site 266265023007 D-loop; other site 266265023008 H-loop/switch region; other site 266265023009 Serine hydrolase; Region: Ser_hydrolase; pfam06821 266265023010 Cytochrome c; Region: Cytochrom_C; cl11414 266265023011 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 266265023012 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 266265023013 dimer interface [polypeptide binding]; other site 266265023014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265023015 catalytic residue [active] 266265023016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265023017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265023018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265023019 dimerization interface [polypeptide binding]; other site 266265023020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265023021 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265023022 putative substrate translocation pore; other site 266265023023 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 266265023024 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 266265023025 tetrameric interface [polypeptide binding]; other site 266265023026 NAD binding site [chemical binding]; other site 266265023027 catalytic residues [active] 266265023028 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265023029 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 266265023030 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 266265023031 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265023032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265023033 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265023034 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265023035 active site 266265023036 enoyl-CoA hydratase; Provisional; Region: PRK09076 266265023037 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023038 substrate binding site [chemical binding]; other site 266265023039 oxyanion hole (OAH) forming residues; other site 266265023040 trimer interface [polypeptide binding]; other site 266265023041 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 266265023042 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023043 substrate binding site [chemical binding]; other site 266265023044 oxyanion hole (OAH) forming residues; other site 266265023045 trimer interface [polypeptide binding]; other site 266265023046 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 266265023047 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 266265023048 Electron transfer flavoprotein domain; Region: ETF; pfam01012 266265023049 Ligand binding site [chemical binding]; other site 266265023050 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 266265023051 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 266265023052 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 266265023053 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 266265023054 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 266265023055 LTXXQ motif family protein; Region: LTXXQ; pfam07813 266265023056 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 266265023057 Mechanosensitive ion channel; Region: MS_channel; pfam00924 266265023058 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265023059 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265023060 ligand binding site [chemical binding]; other site 266265023061 flexible hinge region; other site 266265023062 Isochorismatase family; Region: Isochorismatase; pfam00857 266265023063 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 266265023064 catalytic triad [active] 266265023065 conserved cis-peptide bond; other site 266265023066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265023067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265023068 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 266265023069 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 266265023070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 266265023071 FeS/SAM binding site; other site 266265023072 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 266265023073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265023074 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265023075 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265023076 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265023077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265023078 DNA-binding site [nucleotide binding]; DNA binding site 266265023079 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266265023080 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265023081 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023082 substrate binding site [chemical binding]; other site 266265023083 oxyanion hole (OAH) forming residues; other site 266265023084 trimer interface [polypeptide binding]; other site 266265023085 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266265023086 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023087 enoyl-CoA hydratase; Provisional; Region: PRK06688 266265023088 substrate binding site [chemical binding]; other site 266265023089 oxyanion hole (OAH) forming residues; other site 266265023090 trimer interface [polypeptide binding]; other site 266265023091 benzoate transport; Region: 2A0115; TIGR00895 266265023092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265023093 putative substrate translocation pore; other site 266265023094 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266265023095 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265023096 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265023097 trimer interface [polypeptide binding]; other site 266265023098 eyelet of channel; other site 266265023099 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265023100 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265023101 trimer interface [polypeptide binding]; other site 266265023102 eyelet of channel; other site 266265023103 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265023104 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266265023105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266265023106 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 266265023107 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265023108 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265023109 enoyl-CoA hydratase; Provisional; Region: PRK05981 266265023110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023111 substrate binding site [chemical binding]; other site 266265023112 oxyanion hole (OAH) forming residues; other site 266265023113 trimer interface [polypeptide binding]; other site 266265023114 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265023115 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265023116 active site 266265023117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023118 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 266265023119 substrate binding site [chemical binding]; other site 266265023120 oxyanion hole (OAH) forming residues; other site 266265023121 trimer interface [polypeptide binding]; other site 266265023122 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265023123 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265023124 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 266265023125 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265023126 dimer interface [polypeptide binding]; other site 266265023127 active site 266265023128 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265023129 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265023130 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266265023131 putative active site [active] 266265023132 putative substrate binding site [chemical binding]; other site 266265023133 ATP binding site [chemical binding]; other site 266265023134 Phosphotransferase enzyme family; Region: APH; pfam01636 266265023135 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266265023136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023137 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266265023138 acyl-activating enzyme (AAE) consensus motif; other site 266265023139 acyl-activating enzyme (AAE) consensus motif; other site 266265023140 putative AMP binding site [chemical binding]; other site 266265023141 putative active site [active] 266265023142 putative CoA binding site [chemical binding]; other site 266265023143 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265023144 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023145 substrate binding site [chemical binding]; other site 266265023146 oxyanion hole (OAH) forming residues; other site 266265023147 trimer interface [polypeptide binding]; other site 266265023148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265023149 classical (c) SDRs; Region: SDR_c; cd05233 266265023150 NAD(P) binding site [chemical binding]; other site 266265023151 active site 266265023152 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265023153 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266265023154 FMN-binding pocket [chemical binding]; other site 266265023155 flavin binding motif; other site 266265023156 phosphate binding motif [ion binding]; other site 266265023157 beta-alpha-beta structure motif; other site 266265023158 NAD binding pocket [chemical binding]; other site 266265023159 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265023160 catalytic loop [active] 266265023161 iron binding site [ion binding]; other site 266265023162 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266265023163 Cytochrome P450; Region: p450; cl12078 266265023164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265023165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265023166 Transposase, Mutator family; Region: Transposase_mut; pfam00872 266265023167 MULE transposase domain; Region: MULE; pfam10551 266265023168 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265023169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265023170 DNA-binding site [nucleotide binding]; DNA binding site 266265023171 FCD domain; Region: FCD; pfam07729 266265023172 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 266265023173 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265023174 PYR/PP interface [polypeptide binding]; other site 266265023175 dimer interface [polypeptide binding]; other site 266265023176 TPP binding site [chemical binding]; other site 266265023177 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265023178 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266265023179 TPP-binding site [chemical binding]; other site 266265023180 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 266265023181 dimer interface [polypeptide binding]; other site 266265023182 substrate binding site [chemical binding]; other site 266265023183 metal binding site [ion binding]; metal-binding site 266265023184 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265023185 classical (c) SDRs; Region: SDR_c; cd05233 266265023186 NAD(P) binding site [chemical binding]; other site 266265023187 active site 266265023188 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 266265023189 classical (c) SDRs; Region: SDR_c; cd05233 266265023190 NAD(P) binding site [chemical binding]; other site 266265023191 active site 266265023192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265023193 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265023194 putative substrate translocation pore; other site 266265023195 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265023196 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265023197 trimer interface [polypeptide binding]; other site 266265023198 eyelet of channel; other site 266265023199 succinic semialdehyde dehydrogenase; Region: PLN02278 266265023200 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266265023201 tetramerization interface [polypeptide binding]; other site 266265023202 NAD(P) binding site [chemical binding]; other site 266265023203 catalytic residues [active] 266265023204 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265023205 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 266265023206 NAD(P) binding site [chemical binding]; other site 266265023207 catalytic residues [active] 266265023208 hypothetical protein; Provisional; Region: PRK06847 266265023209 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265023210 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 266265023211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265023212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265023213 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 266265023214 Transcriptional regulators [Transcription]; Region: PurR; COG1609 266265023215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 266265023216 DNA binding site [nucleotide binding] 266265023217 domain linker motif; other site 266265023218 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 266265023219 putative dimerization interface [polypeptide binding]; other site 266265023220 putative ligand binding site [chemical binding]; other site 266265023221 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265023222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265023223 NAD(P) binding site [chemical binding]; other site 266265023224 active site 266265023225 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 266265023226 histidinol dehydrogenase; Region: hisD; TIGR00069 266265023227 NAD binding site [chemical binding]; other site 266265023228 dimerization interface [polypeptide binding]; other site 266265023229 product binding site; other site 266265023230 substrate binding site [chemical binding]; other site 266265023231 zinc binding site [ion binding]; other site 266265023232 catalytic residues [active] 266265023233 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266265023234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265023235 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265023236 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266265023237 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023238 acyl-activating enzyme (AAE) consensus motif; other site 266265023239 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 266265023240 acyl-activating enzyme (AAE) consensus motif; other site 266265023241 putative AMP binding site [chemical binding]; other site 266265023242 putative active site [active] 266265023243 putative CoA binding site [chemical binding]; other site 266265023244 enoyl-CoA hydratase; Provisional; Region: PRK12478 266265023245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023246 substrate binding site [chemical binding]; other site 266265023247 oxyanion hole (OAH) forming residues; other site 266265023248 trimer interface [polypeptide binding]; other site 266265023249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023250 enoyl-CoA hydratase; Provisional; Region: PRK06494 266265023251 substrate binding site [chemical binding]; other site 266265023252 oxyanion hole (OAH) forming residues; other site 266265023253 trimer interface [polypeptide binding]; other site 266265023254 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265023255 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023256 acyl-activating enzyme (AAE) consensus motif; other site 266265023257 AMP binding site [chemical binding]; other site 266265023258 active site 266265023259 CoA binding site [chemical binding]; other site 266265023260 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265023261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023262 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023263 acyl-activating enzyme (AAE) consensus motif; other site 266265023264 acyl-activating enzyme (AAE) consensus motif; other site 266265023265 AMP binding site [chemical binding]; other site 266265023266 active site 266265023267 CoA binding site [chemical binding]; other site 266265023268 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 266265023269 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 266265023270 ATP-grasp domain; Region: ATP-grasp_4; cl17255 266265023271 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 266265023272 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 266265023273 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 266265023274 carboxyltransferase (CT) interaction site; other site 266265023275 biotinylation site [posttranslational modification]; other site 266265023276 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 266265023277 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 266265023278 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 266265023279 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265023280 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265023281 trimer interface [polypeptide binding]; other site 266265023282 eyelet of channel; other site 266265023283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265023284 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265023285 putative substrate translocation pore; other site 266265023286 enoyl-CoA hydratase; Provisional; Region: PRK06688 266265023287 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023288 substrate binding site [chemical binding]; other site 266265023289 oxyanion hole (OAH) forming residues; other site 266265023290 trimer interface [polypeptide binding]; other site 266265023291 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 266265023292 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265023293 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265023294 beta-ketothiolase; Provisional; Region: PRK09051 266265023295 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265023296 dimer interface [polypeptide binding]; other site 266265023297 active site 266265023298 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266265023299 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 266265023300 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 266265023301 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266265023302 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266265023303 transmembrane helices; other site 266265023304 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266265023305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265023306 DNA-binding site [nucleotide binding]; DNA binding site 266265023307 UTRA domain; Region: UTRA; pfam07702 266265023308 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 266265023309 substrate binding site [chemical binding]; other site 266265023310 amidase catalytic site [active] 266265023311 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 266265023312 Zn binding residues [ion binding]; other site 266265023313 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 266265023314 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 266265023315 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 266265023316 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265023317 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265023318 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265023319 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265023320 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265023321 trimer interface [polypeptide binding]; other site 266265023322 eyelet of channel; other site 266265023323 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266265023324 DUF35 OB-fold domain; Region: DUF35; pfam01796 266265023325 lipid-transfer protein; Provisional; Region: PRK07855 266265023326 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265023327 active site 266265023328 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265023329 benzoate transport; Region: 2A0115; TIGR00895 266265023330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265023331 putative substrate translocation pore; other site 266265023332 AMP-binding domain protein; Validated; Region: PRK08315 266265023333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023334 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 266265023335 acyl-activating enzyme (AAE) consensus motif; other site 266265023336 acyl-activating enzyme (AAE) consensus motif; other site 266265023337 putative AMP binding site [chemical binding]; other site 266265023338 putative active site [active] 266265023339 putative CoA binding site [chemical binding]; other site 266265023340 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265023341 classical (c) SDRs; Region: SDR_c; cd05233 266265023342 NAD(P) binding site [chemical binding]; other site 266265023343 active site 266265023344 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265023345 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266265023346 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 266265023347 NapD protein; Region: NapD; pfam03927 266265023348 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 266265023349 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 266265023350 [4Fe-4S] binding site [ion binding]; other site 266265023351 molybdopterin cofactor binding site; other site 266265023352 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 266265023353 molybdopterin cofactor binding site; other site 266265023354 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 266265023355 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 266265023356 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 266265023357 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 266265023358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265023359 Walker A/P-loop; other site 266265023360 ATP binding site [chemical binding]; other site 266265023361 Q-loop/lid; other site 266265023362 ABC transporter signature motif; other site 266265023363 Walker B; other site 266265023364 D-loop; other site 266265023365 H-loop/switch region; other site 266265023366 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 266265023367 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 266265023368 CcmE; Region: CcmE; pfam03100 266265023369 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 266265023370 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 266265023371 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 266265023372 catalytic residues [active] 266265023373 central insert; other site 266265023374 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 266265023375 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 266265023376 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 266265023377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266265023378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 266265023379 TPR motif; other site 266265023380 binding surface 266265023381 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266265023382 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266265023383 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266265023384 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265023385 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266265023386 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265023387 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266265023388 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 266265023389 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 266265023390 putative active site [active] 266265023391 Zn binding site [ion binding]; other site 266265023392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265023393 Coenzyme A binding pocket [chemical binding]; other site 266265023394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265023395 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265023396 substrate binding pocket [chemical binding]; other site 266265023397 membrane-bound complex binding site; other site 266265023398 hinge residues; other site 266265023399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266265023400 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266265023401 lipoprotein signal peptidase; Provisional; Region: PRK14776 266265023402 Heavy-metal-associated domain; Region: HMA; pfam00403 266265023403 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265023404 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266265023405 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266265023406 DNA binding residues [nucleotide binding] 266265023407 dimer interface [polypeptide binding]; other site 266265023408 putative metal binding site [ion binding]; other site 266265023409 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265023410 N-terminal plug; other site 266265023411 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 266265023412 ligand-binding site [chemical binding]; other site 266265023413 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 266265023414 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266265023415 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 266265023416 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 266265023417 active site 266265023418 non-prolyl cis peptide bond; other site 266265023419 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265023420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265023421 dimer interface [polypeptide binding]; other site 266265023422 conserved gate region; other site 266265023423 putative PBP binding loops; other site 266265023424 ABC-ATPase subunit interface; other site 266265023425 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265023426 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265023427 Walker A/P-loop; other site 266265023428 ATP binding site [chemical binding]; other site 266265023429 Q-loop/lid; other site 266265023430 ABC transporter signature motif; other site 266265023431 Walker B; other site 266265023432 D-loop; other site 266265023433 H-loop/switch region; other site 266265023434 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265023435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265023436 substrate binding pocket [chemical binding]; other site 266265023437 membrane-bound complex binding site; other site 266265023438 hinge residues; other site 266265023439 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 266265023440 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266265023441 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266265023442 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 266265023443 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265023444 N-terminal plug; other site 266265023445 ligand-binding site [chemical binding]; other site 266265023446 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 266265023447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265023448 Coenzyme A binding pocket [chemical binding]; other site 266265023449 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 266265023450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265023451 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265023452 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 266265023453 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265023454 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266265023455 FMN-binding pocket [chemical binding]; other site 266265023456 flavin binding motif; other site 266265023457 phosphate binding motif [ion binding]; other site 266265023458 beta-alpha-beta structure motif; other site 266265023459 NAD binding pocket [chemical binding]; other site 266265023460 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266265023461 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265023462 catalytic loop [active] 266265023463 iron binding site [ion binding]; other site 266265023464 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265023465 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265023466 [2Fe-2S] cluster binding site [ion binding]; other site 266265023467 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 266265023468 alpha subunit interface [polypeptide binding]; other site 266265023469 active site 266265023470 substrate binding site [chemical binding]; other site 266265023471 Fe binding site [ion binding]; other site 266265023472 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266265023473 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266265023474 active site 266265023475 Int/Topo IB signature motif; other site 266265023476 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 266265023477 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266265023478 active site 266265023479 Int/Topo IB signature motif; other site 266265023480 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 266265023481 Autoinducer synthetase; Region: Autoind_synth; cl17404 266265023482 Autoinducer binding domain; Region: Autoind_bind; pfam03472 266265023483 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265023484 DNA binding residues [nucleotide binding] 266265023485 dimerization interface [polypeptide binding]; other site 266265023486 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266265023487 active site 266265023488 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266265023489 active site 266265023490 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 266265023491 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265023492 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265023493 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265023494 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 266265023495 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 266265023496 dimer interface [polypeptide binding]; other site 266265023497 active site 266265023498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 266265023499 catalytic residues [active] 266265023500 substrate binding site [chemical binding]; other site 266265023501 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 266265023502 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023503 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023504 acyl-activating enzyme (AAE) consensus motif; other site 266265023505 acyl-activating enzyme (AAE) consensus motif; other site 266265023506 AMP binding site [chemical binding]; other site 266265023507 active site 266265023508 CoA binding site [chemical binding]; other site 266265023509 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266265023510 hypothetical protein; Validated; Region: PRK06840 266265023511 active site 266265023512 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266265023513 active site 266265023514 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 266265023515 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266265023516 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265023517 active site 266265023518 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265023519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265023520 DNA-binding site [nucleotide binding]; DNA binding site 266265023521 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 266265023522 putative amidase; Provisional; Region: PRK06169 266265023523 Amidase; Region: Amidase; pfam01425 266265023524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265023525 non-specific DNA binding site [nucleotide binding]; other site 266265023526 salt bridge; other site 266265023527 sequence-specific DNA binding site [nucleotide binding]; other site 266265023528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265023529 non-specific DNA binding site [nucleotide binding]; other site 266265023530 salt bridge; other site 266265023531 sequence-specific DNA binding site [nucleotide binding]; other site 266265023532 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265023533 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265023534 TM-ABC transporter signature motif; other site 266265023535 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265023536 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265023537 TM-ABC transporter signature motif; other site 266265023538 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265023539 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 266265023540 Walker A/P-loop; other site 266265023541 ATP binding site [chemical binding]; other site 266265023542 Q-loop/lid; other site 266265023543 ABC transporter signature motif; other site 266265023544 Walker B; other site 266265023545 D-loop; other site 266265023546 H-loop/switch region; other site 266265023547 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265023548 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265023549 Walker A/P-loop; other site 266265023550 ATP binding site [chemical binding]; other site 266265023551 Q-loop/lid; other site 266265023552 ABC transporter signature motif; other site 266265023553 Walker B; other site 266265023554 D-loop; other site 266265023555 H-loop/switch region; other site 266265023556 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265023557 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 266265023558 ligand binding site [chemical binding]; other site 266265023559 putative amidase; Provisional; Region: PRK06169 266265023560 Amidase; Region: Amidase; cl11426 266265023561 Amino acid synthesis; Region: AA_synth; pfam06684 266265023562 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265023563 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265023564 trimer interface [polypeptide binding]; other site 266265023565 eyelet of channel; other site 266265023566 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 266265023567 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266265023568 oligomeric interface; other site 266265023569 putative active site [active] 266265023570 homodimer interface [polypeptide binding]; other site 266265023571 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 266265023572 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265023573 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 266265023574 N-acetyl-D-glucosamine binding site [chemical binding]; other site 266265023575 catalytic residue [active] 266265023576 TrbC/VIRB2 family; Region: TrbC; cl01583 266265023577 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 266265023578 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 266265023579 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 266265023580 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 266265023581 Type IV secretion system proteins; Region: T4SS; pfam07996 266265023582 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 266265023583 VirB8 protein; Region: VirB8; pfam04335 266265023584 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 266265023585 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 266265023586 VirB7 interaction site; other site 266265023587 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 266265023588 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 266265023589 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 266265023590 Walker A motif; other site 266265023591 hexamer interface [polypeptide binding]; other site 266265023592 ATP binding site [chemical binding]; other site 266265023593 Walker B motif; other site 266265023594 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 266265023595 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 266265023596 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 266265023597 Walker A motif; other site 266265023598 ATP binding site [chemical binding]; other site 266265023599 Walker B motif; other site 266265023600 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 266265023601 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 266265023602 active site 266265023603 metal binding site [ion binding]; metal-binding site 266265023604 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 266265023605 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 266265023606 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 266265023607 cyanate hydratase; Validated; Region: PRK02866 266265023608 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 266265023609 oligomer interface [polypeptide binding]; other site 266265023610 active site 266265023611 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 266265023612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 266265023613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 266265023614 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265023615 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 266265023616 Transposase; Region: HTH_Tnp_1; pfam01527 266265023617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265023618 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 266265023619 ParB-like nuclease domain; Region: ParBc; pfam02195 266265023620 Domain of unknown function (DUF932); Region: DUF932; pfam06067 266265023621 Cupin domain; Region: Cupin_2; cl17218 266265023622 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265023623 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 266265023624 transmembrane helices; other site 266265023625 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 266265023626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265023627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265023628 dimerization interface [polypeptide binding]; other site 266265023629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266265023630 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265023631 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265023632 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 266265023633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266265023634 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265023635 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265023636 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266265023637 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265023638 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 266265023639 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 266265023640 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266265023641 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265023642 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265023643 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 266265023644 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265023645 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265023646 trimer interface [polypeptide binding]; other site 266265023647 eyelet of channel; other site 266265023648 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265023649 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 266265023650 putative ligand binding site [chemical binding]; other site 266265023651 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265023652 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265023653 TM-ABC transporter signature motif; other site 266265023654 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265023655 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265023656 TM-ABC transporter signature motif; other site 266265023657 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265023658 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265023659 Walker A/P-loop; other site 266265023660 ATP binding site [chemical binding]; other site 266265023661 Q-loop/lid; other site 266265023662 ABC transporter signature motif; other site 266265023663 Walker B; other site 266265023664 D-loop; other site 266265023665 H-loop/switch region; other site 266265023666 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265023667 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265023668 Walker A/P-loop; other site 266265023669 ATP binding site [chemical binding]; other site 266265023670 Q-loop/lid; other site 266265023671 ABC transporter signature motif; other site 266265023672 Walker B; other site 266265023673 D-loop; other site 266265023674 H-loop/switch region; other site 266265023675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265023676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265023677 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266265023678 putative dimerization interface [polypeptide binding]; other site 266265023679 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266265023680 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 266265023681 Cupin domain; Region: Cupin_2; cl17218 266265023682 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 266265023683 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 266265023684 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 266265023685 Predicted oxidoreductase [General function prediction only]; Region: COG3573 266265023686 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 266265023687 hydrophobic ligand binding site; other site 266265023688 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 266265023689 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266265023690 DUF35 OB-fold domain; Region: DUF35; pfam01796 266265023691 lipid-transfer protein; Provisional; Region: PRK07855 266265023692 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265023693 active site 266265023694 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266265023695 active site 266265023696 catalytic site [active] 266265023697 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 266265023698 putative active site [active] 266265023699 putative catalytic site [active] 266265023700 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265023701 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266265023702 active site 266265023703 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265023704 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266265023705 putative ligand binding site [chemical binding]; other site 266265023706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023707 enoyl-CoA hydratase; Provisional; Region: PRK06688 266265023708 substrate binding site [chemical binding]; other site 266265023709 oxyanion hole (OAH) forming residues; other site 266265023710 trimer interface [polypeptide binding]; other site 266265023711 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 266265023712 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023713 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023714 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266265023715 acyl-activating enzyme (AAE) consensus motif; other site 266265023716 acyl-activating enzyme (AAE) consensus motif; other site 266265023717 putative AMP binding site [chemical binding]; other site 266265023718 putative active site [active] 266265023719 putative CoA binding site [chemical binding]; other site 266265023720 SnoaL-like domain; Region: SnoaL_4; pfam13577 266265023721 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266265023722 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265023723 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265023724 ligand binding site [chemical binding]; other site 266265023725 flexible hinge region; other site 266265023726 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266265023727 CheB methylesterase; Region: CheB_methylest; pfam01339 266265023728 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 266265023729 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 266265023730 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 266265023731 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 266265023732 PAS domain; Region: PAS_10; pfam13596 266265023733 PAS domain S-box; Region: sensory_box; TIGR00229 266265023734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265023735 putative active site [active] 266265023736 heme pocket [chemical binding]; other site 266265023737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265023738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265023739 dimer interface [polypeptide binding]; other site 266265023740 phosphorylation site [posttranslational modification] 266265023741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265023742 ATP binding site [chemical binding]; other site 266265023743 Mg2+ binding site [ion binding]; other site 266265023744 G-X-G motif; other site 266265023745 Response regulator receiver domain; Region: Response_reg; pfam00072 266265023746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265023747 active site 266265023748 phosphorylation site [posttranslational modification] 266265023749 intermolecular recognition site; other site 266265023750 dimerization interface [polypeptide binding]; other site 266265023751 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266265023752 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 266265023753 NAD(P) binding site [chemical binding]; other site 266265023754 catalytic residues [active] 266265023755 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 266265023756 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 266265023757 ligand binding site [chemical binding]; other site 266265023758 homodimer interface [polypeptide binding]; other site 266265023759 NAD(P) binding site [chemical binding]; other site 266265023760 trimer interface B [polypeptide binding]; other site 266265023761 trimer interface A [polypeptide binding]; other site 266265023762 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 266265023763 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 266265023764 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 266265023765 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 266265023766 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 266265023767 NAD binding site [chemical binding]; other site 266265023768 substrate binding site [chemical binding]; other site 266265023769 catalytic Zn binding site [ion binding]; other site 266265023770 tetramer interface [polypeptide binding]; other site 266265023771 structural Zn binding site [ion binding]; other site 266265023772 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 266265023773 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, hoxF; composed of proteins similar to the NAD-reducing hydrogenase (hoxS) alpha subunit of Alcaligenes eutrophus H16. HoxS is a cytoplasmic hydrogenase...; Region: TRX_Fd_NuoE_hoxF; cd03083 266265023774 putative dimer interface [polypeptide binding]; other site 266265023775 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 266265023776 SLBB domain; Region: SLBB; pfam10531 266265023777 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 266265023778 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265023779 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 266265023780 catalytic loop [active] 266265023781 iron binding site [ion binding]; other site 266265023782 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 266265023783 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 266265023784 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 266265023785 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 266265023786 nickel binding site [ion binding]; other site 266265023787 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 266265023788 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 266265023789 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265023790 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 266265023791 Acylphosphatase; Region: Acylphosphatase; pfam00708 266265023792 HypF finger; Region: zf-HYPF; pfam07503 266265023793 HypF finger; Region: zf-HYPF; pfam07503 266265023794 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 266265023795 HupF/HypC family; Region: HupF_HypC; cl00394 266265023796 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 266265023797 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 266265023798 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 266265023799 dimerization interface [polypeptide binding]; other site 266265023800 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 266265023801 ATP binding site [chemical binding]; other site 266265023802 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 266265023803 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 266265023804 putative active site [active] 266265023805 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 266265023806 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265023807 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265023808 ligand binding site [chemical binding]; other site 266265023809 flexible hinge region; other site 266265023810 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 266265023811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 266265023812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265023813 dimer interface [polypeptide binding]; other site 266265023814 phosphorylation site [posttranslational modification] 266265023815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265023816 ATP binding site [chemical binding]; other site 266265023817 Mg2+ binding site [ion binding]; other site 266265023818 G-X-G motif; other site 266265023819 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 266265023820 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 266265023821 phosphoglucomutase; Validated; Region: PRK07564 266265023822 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 266265023823 active site 266265023824 substrate binding site [chemical binding]; other site 266265023825 metal binding site [ion binding]; metal-binding site 266265023826 PRC-barrel domain; Region: PRC; pfam05239 266265023827 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 266265023828 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 266265023829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265023830 catalytic residue [active] 266265023831 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 266265023832 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 266265023833 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266265023834 PRC-barrel domain; Region: PRC; pfam05239 266265023835 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 266265023836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265023837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265023838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265023839 dimerization interface [polypeptide binding]; other site 266265023840 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266265023841 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265023842 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 266265023843 putative ligand binding site [chemical binding]; other site 266265023844 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265023845 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265023846 TM-ABC transporter signature motif; other site 266265023847 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265023848 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265023849 TM-ABC transporter signature motif; other site 266265023850 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265023851 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265023852 Walker A/P-loop; other site 266265023853 ATP binding site [chemical binding]; other site 266265023854 Q-loop/lid; other site 266265023855 ABC transporter signature motif; other site 266265023856 Walker B; other site 266265023857 D-loop; other site 266265023858 H-loop/switch region; other site 266265023859 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265023860 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265023861 Walker A/P-loop; other site 266265023862 ATP binding site [chemical binding]; other site 266265023863 Q-loop/lid; other site 266265023864 ABC transporter signature motif; other site 266265023865 Walker B; other site 266265023866 D-loop; other site 266265023867 H-loop/switch region; other site 266265023868 enoyl-CoA hydratase; Provisional; Region: PRK08290 266265023869 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023870 substrate binding site [chemical binding]; other site 266265023871 oxyanion hole (OAH) forming residues; other site 266265023872 trimer interface [polypeptide binding]; other site 266265023873 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023874 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 266265023875 substrate binding site [chemical binding]; other site 266265023876 oxyanion hole (OAH) forming residues; other site 266265023877 trimer interface [polypeptide binding]; other site 266265023878 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 266265023879 CoA binding domain; Region: CoA_binding_2; pfam13380 266265023880 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 266265023881 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 266265023882 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 266265023883 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265023884 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265023885 trimer interface [polypeptide binding]; other site 266265023886 eyelet of channel; other site 266265023887 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 266265023888 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 266265023889 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 266265023890 active site 266265023891 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265023892 Uncharacterized conserved protein [Function unknown]; Region: COG3777 266265023893 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266265023894 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266265023895 active site 2 [active] 266265023896 active site 1 [active] 266265023897 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265023898 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266265023899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265023900 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266265023901 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265023902 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265023903 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266265023904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265023905 putative substrate translocation pore; other site 266265023906 thiolase; Provisional; Region: PRK06158 266265023907 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265023908 active site 266265023909 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266265023910 DUF35 OB-fold domain; Region: DUF35; pfam01796 266265023911 short chain dehydrogenase; Provisional; Region: PRK12828 266265023912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265023913 NAD(P) binding site [chemical binding]; other site 266265023914 active site 266265023915 Hemerythrin; Region: Hemerythrin; cd12107 266265023916 Fe binding site [ion binding]; other site 266265023917 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265023918 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265023919 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit (DitA) of diterpenoid dioxygenase (DTDO). DTDO is a novel aromatic-ring-hydroxylating dioxygenase found in Pseudomonas and other proteobacteria that degrades...; Region: Rieske_RO_Alpha_DTDO; cd03536 266265023920 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 266265023921 beta subunit interface [polypeptide binding]; other site 266265023922 alpha subunit interface [polypeptide binding]; other site 266265023923 active site 266265023924 substrate binding site [chemical binding]; other site 266265023925 Fe binding site [ion binding]; other site 266265023926 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265023927 inter-subunit interface; other site 266265023928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265023929 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 266265023930 dimer interface [polypeptide binding]; other site 266265023931 putative metal binding site [ion binding]; other site 266265023932 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266265023933 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265023934 putative NAD(P) binding site [chemical binding]; other site 266265023935 putative active site [active] 266265023936 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 266265023937 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265023938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265023939 NAD(P) binding site [chemical binding]; other site 266265023940 active site 266265023941 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 266265023942 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265023943 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 266265023944 acyl-activating enzyme (AAE) consensus motif; other site 266265023945 putative AMP binding site [chemical binding]; other site 266265023946 putative active site [active] 266265023947 putative CoA binding site [chemical binding]; other site 266265023948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265023949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265023950 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265023951 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 266265023952 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265023953 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265023954 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 266265023955 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265023956 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265023957 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265023958 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 266265023959 dimer interface [polypeptide binding]; other site 266265023960 active site 266265023961 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266265023962 Cytochrome P450; Region: p450; cl12078 266265023963 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265023964 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265023965 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265023966 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265023967 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266265023968 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265023969 catalytic loop [active] 266265023970 iron binding site [ion binding]; other site 266265023971 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265023972 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265023973 active site 266265023974 enoyl-CoA hydratase; Provisional; Region: PRK09245 266265023975 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265023976 substrate binding site [chemical binding]; other site 266265023977 oxyanion hole (OAH) forming residues; other site 266265023978 trimer interface [polypeptide binding]; other site 266265023979 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265023980 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 266265023981 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265023982 active site 266265023983 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265023984 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265023985 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265023986 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265023987 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 266265023988 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265023989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265023990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265023991 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265023992 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266265023993 putative NAD(P) binding site [chemical binding]; other site 266265023994 putative active site [active] 266265023995 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265023996 dimerization interface [polypeptide binding]; other site 266265023997 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265023998 dimer interface [polypeptide binding]; other site 266265023999 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266265024000 putative CheW interface [polypeptide binding]; other site 266265024001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265024002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265024003 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 266265024004 putative substrate binding pocket [chemical binding]; other site 266265024005 dimerization interface [polypeptide binding]; other site 266265024006 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13029 266265024007 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 266265024008 dimer interface [polypeptide binding]; other site 266265024009 PYR/PP interface [polypeptide binding]; other site 266265024010 TPP binding site [chemical binding]; other site 266265024011 substrate binding site [chemical binding]; other site 266265024012 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 266265024013 TPP-binding site [chemical binding]; other site 266265024014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 266265024015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024016 putative substrate translocation pore; other site 266265024017 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 266265024018 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265024019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265024020 NAD(P) binding site [chemical binding]; other site 266265024021 active site 266265024022 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265024023 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265024024 active site 266265024025 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 266265024026 putative active site [active] 266265024027 putative substrate binding site [chemical binding]; other site 266265024028 ATP binding site [chemical binding]; other site 266265024029 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265024030 classical (c) SDRs; Region: SDR_c; cd05233 266265024031 NAD(P) binding site [chemical binding]; other site 266265024032 active site 266265024033 secoisolariciresinol dehydrogenase (secoisolariciresinol-DH)-like, classical (c) SDRs; Region: secoisolariciresinol-DH_like_SDR_c; cd05326 266265024034 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265024035 NAD binding site [chemical binding]; other site 266265024036 homodimer interface [polypeptide binding]; other site 266265024037 substrate binding site [chemical binding]; other site 266265024038 active site 266265024039 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265024040 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265024041 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265024042 iron-sulfur cluster [ion binding]; other site 266265024043 [2Fe-2S] cluster binding site [ion binding]; other site 266265024044 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265024045 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266265024046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265024047 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 266265024048 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 266265024049 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265024050 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 266265024051 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 266265024052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265024053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265024054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265024055 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266265024056 Cytochrome P450; Region: p450; cl12078 266265024057 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265024058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265024059 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 266265024060 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 266265024061 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 266265024062 putative catalytic cysteine [active] 266265024063 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266265024064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265024065 NAD(P) binding site [chemical binding]; other site 266265024066 active site 266265024067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265024068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265024069 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 266265024070 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265024071 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 266265024072 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265024073 classical (c) SDRs; Region: SDR_c; cd05233 266265024074 NAD(P) binding site [chemical binding]; other site 266265024075 active site 266265024076 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 266265024077 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 266265024078 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 266265024079 active site 266265024080 Fe binding site [ion binding]; other site 266265024081 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265024082 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265024083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265024084 NAD(P) binding site [chemical binding]; other site 266265024085 active site 266265024086 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265024087 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024088 substrate binding site [chemical binding]; other site 266265024089 oxyanion hole (OAH) forming residues; other site 266265024090 trimer interface [polypeptide binding]; other site 266265024091 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 266265024092 active site 266265024093 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 266265024094 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 266265024095 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 266265024096 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 266265024097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265024098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265024099 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265024100 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 266265024101 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265024102 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265024103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024104 D-galactonate transporter; Region: 2A0114; TIGR00893 266265024105 putative substrate translocation pore; other site 266265024106 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 266265024107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265024109 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265024110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265024111 active site 266265024112 Uncharacterized conserved protein [Function unknown]; Region: COG3777 266265024113 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 266265024114 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 266265024115 putative active site [active] 266265024116 putative catalytic site [active] 266265024117 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265024118 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265024119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265024120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265024121 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266265024122 putative dimerization interface [polypeptide binding]; other site 266265024123 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266265024124 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266265024125 tetramer interface [polypeptide binding]; other site 266265024126 active site 266265024127 Mg2+/Mn2+ binding site [ion binding]; other site 266265024128 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266265024129 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265024130 active site 266265024131 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 266265024132 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 266265024133 tetramer interface [polypeptide binding]; other site 266265024134 active site 266265024135 Mg2+/Mn2+ binding site [ion binding]; other site 266265024136 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 266265024137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265024138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265024139 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 266265024140 putative dimerization interface [polypeptide binding]; other site 266265024141 thiamine pyrophosphate protein; Validated; Region: PRK08199 266265024142 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265024143 PYR/PP interface [polypeptide binding]; other site 266265024144 dimer interface [polypeptide binding]; other site 266265024145 TPP binding site [chemical binding]; other site 266265024146 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265024147 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266265024148 TPP-binding site [chemical binding]; other site 266265024149 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 266265024150 isocitrate dehydrogenase; Validated; Region: PRK06451 266265024151 succinic semialdehyde dehydrogenase; Region: PLN02278 266265024152 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266265024153 tetramerization interface [polypeptide binding]; other site 266265024154 NAD(P) binding site [chemical binding]; other site 266265024155 catalytic residues [active] 266265024156 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024157 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024158 trimer interface [polypeptide binding]; other site 266265024159 eyelet of channel; other site 266265024160 benzoate transport; Region: 2A0115; TIGR00895 266265024161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024163 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266265024164 Winged helix-turn helix; Region: HTH_29; pfam13551 266265024165 Integrase core domain; Region: rve; pfam00665 266265024166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265024167 short chain dehydrogenase; Validated; Region: PRK07069 266265024168 NAD(P) binding site [chemical binding]; other site 266265024169 active site 266265024170 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 266265024171 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265024172 HTH-like domain; Region: HTH_21; pfam13276 266265024173 Integrase core domain; Region: rve; pfam00665 266265024174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 266265024175 Transposase; Region: HTH_Tnp_1; pfam01527 266265024176 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 266265024177 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 266265024178 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 266265024179 oligomeric interface; other site 266265024180 putative active site [active] 266265024181 homodimer interface [polypeptide binding]; other site 266265024182 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 266265024183 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 266265024184 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265024185 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265024186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265024187 dimer interface [polypeptide binding]; other site 266265024188 conserved gate region; other site 266265024189 ABC-ATPase subunit interface; other site 266265024190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265024191 Walker A/P-loop; other site 266265024192 ATP binding site [chemical binding]; other site 266265024193 ABC transporter; Region: ABC_tran; pfam00005 266265024194 Q-loop/lid; other site 266265024195 ABC transporter signature motif; other site 266265024196 Walker B; other site 266265024197 D-loop; other site 266265024198 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 266265024199 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 266265024200 Predicted transcriptional regulator [Transcription]; Region: COG4190 266265024201 MarR family; Region: MarR_2; cl17246 266265024202 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 266265024203 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 266265024204 Winged helix-turn helix; Region: HTH_29; pfam13551 266265024205 Integrase core domain; Region: rve; pfam00665 266265024206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 266265024207 Integrase core domain; Region: rve_3; cl15866 266265024208 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265024209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265024210 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266265024211 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266265024212 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266265024213 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266265024214 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266265024215 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 266265024216 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265024217 Walker A/P-loop; other site 266265024218 ATP binding site [chemical binding]; other site 266265024219 Q-loop/lid; other site 266265024220 ABC transporter signature motif; other site 266265024221 Walker B; other site 266265024222 D-loop; other site 266265024223 H-loop/switch region; other site 266265024224 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 266265024225 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 266265024226 Walker A/P-loop; other site 266265024227 ATP binding site [chemical binding]; other site 266265024228 Q-loop/lid; other site 266265024229 ABC transporter signature motif; other site 266265024230 Walker B; other site 266265024231 D-loop; other site 266265024232 H-loop/switch region; other site 266265024233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 266265024234 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 266265024235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265024236 dimer interface [polypeptide binding]; other site 266265024237 conserved gate region; other site 266265024238 ABC-ATPase subunit interface; other site 266265024239 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 266265024240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265024241 dimer interface [polypeptide binding]; other site 266265024242 conserved gate region; other site 266265024243 putative PBP binding loops; other site 266265024244 ABC-ATPase subunit interface; other site 266265024245 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 266265024246 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 266265024247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266265024248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265024249 Coenzyme A binding pocket [chemical binding]; other site 266265024250 hypothetical protein; Provisional; Region: PRK05965 266265024251 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 266265024252 inhibitor-cofactor binding pocket; inhibition site 266265024253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 266265024254 catalytic residue [active] 266265024255 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265024256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265024257 putative DNA binding site [nucleotide binding]; other site 266265024258 putative Zn2+ binding site [ion binding]; other site 266265024259 AsnC family; Region: AsnC_trans_reg; pfam01037 266265024260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265024261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265024262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265024263 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265024264 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 266265024265 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 266265024266 NAD(P) binding pocket [chemical binding]; other site 266265024267 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 266265024268 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 266265024269 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265024270 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265024271 Walker A/P-loop; other site 266265024272 ATP binding site [chemical binding]; other site 266265024273 Q-loop/lid; other site 266265024274 ABC transporter signature motif; other site 266265024275 Walker B; other site 266265024276 D-loop; other site 266265024277 H-loop/switch region; other site 266265024278 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265024279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265024280 dimer interface [polypeptide binding]; other site 266265024281 conserved gate region; other site 266265024282 putative PBP binding loops; other site 266265024283 ABC-ATPase subunit interface; other site 266265024284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265024285 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265024286 substrate binding pocket [chemical binding]; other site 266265024287 membrane-bound complex binding site; other site 266265024288 hinge residues; other site 266265024289 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265024290 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265024291 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 266265024292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 266265024293 motif II; other site 266265024294 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265024295 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265024296 NAD(P) binding site [chemical binding]; other site 266265024297 catalytic residues [active] 266265024298 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 266265024299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265024300 non-specific DNA binding site [nucleotide binding]; other site 266265024301 salt bridge; other site 266265024302 sequence-specific DNA binding site [nucleotide binding]; other site 266265024303 Cupin domain; Region: Cupin_2; pfam07883 266265024304 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 266265024305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 266265024306 Coenzyme A binding pocket [chemical binding]; other site 266265024307 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266265024308 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 266265024309 putative ligand binding site [chemical binding]; other site 266265024310 NAD binding site [chemical binding]; other site 266265024311 dimerization interface [polypeptide binding]; other site 266265024312 catalytic site [active] 266265024313 tartrate dehydrogenase; Region: TTC; TIGR02089 266265024314 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266265024315 succinic semialdehyde dehydrogenase; Region: PLN02278 266265024316 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 266265024317 tetramerization interface [polypeptide binding]; other site 266265024318 NAD(P) binding site [chemical binding]; other site 266265024319 catalytic residues [active] 266265024320 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 266265024321 putative active site [active] 266265024322 Zn binding site [ion binding]; other site 266265024323 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 266265024324 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265024325 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 266265024326 EamA-like transporter family; Region: EamA; pfam00892 266265024327 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 266265024328 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265024329 MarR family; Region: MarR_2; pfam12802 266265024330 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 266265024331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024332 putative substrate translocation pore; other site 266265024333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 266265024334 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 266265024335 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 266265024336 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266265024337 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 266265024338 catalytic nucleophile [active] 266265024339 PAS domain S-box; Region: sensory_box; TIGR00229 266265024340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265024341 putative active site [active] 266265024342 heme pocket [chemical binding]; other site 266265024343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 266265024344 Histidine kinase; Region: HisKA_3; pfam07730 266265024345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265024346 ATP binding site [chemical binding]; other site 266265024347 Mg2+ binding site [ion binding]; other site 266265024348 G-X-G motif; other site 266265024349 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 266265024350 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 266265024351 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265024352 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 266265024353 ligand binding site [chemical binding]; other site 266265024354 flexible hinge region; other site 266265024355 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 266265024356 putative switch regulator; other site 266265024357 non-specific DNA interactions [nucleotide binding]; other site 266265024358 DNA binding site [nucleotide binding] 266265024359 sequence specific DNA binding site [nucleotide binding]; other site 266265024360 putative cAMP binding site [chemical binding]; other site 266265024361 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 266265024362 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 266265024363 putative substrate binding site [chemical binding]; other site 266265024364 nucleotide binding site [chemical binding]; other site 266265024365 nucleotide binding site [chemical binding]; other site 266265024366 homodimer interface [polypeptide binding]; other site 266265024367 ornithine carbamoyltransferase; Validated; Region: PRK02102 266265024368 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 266265024369 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 266265024370 arginine deiminase; Provisional; Region: PRK01388 266265024371 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 266265024372 ornithine decarboxylase; Provisional; Region: PRK13578 266265024373 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266265024374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265024375 catalytic residue [active] 266265024376 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 266265024377 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 266265024378 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 266265024379 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 266265024380 Helix-turn-helix domain; Region: HTH_38; pfam13936 266265024381 Integrase core domain; Region: rve; pfam00665 266265024382 RES domain; Region: RES; smart00953 266265024383 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266265024384 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265024385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265024386 DNA-binding site [nucleotide binding]; DNA binding site 266265024387 FCD domain; Region: FCD; pfam07729 266265024388 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265024389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265024390 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265024391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265024392 dimer interface [polypeptide binding]; other site 266265024393 conserved gate region; other site 266265024394 putative PBP binding loops; other site 266265024395 ABC-ATPase subunit interface; other site 266265024396 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265024397 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265024398 Walker A/P-loop; other site 266265024399 ATP binding site [chemical binding]; other site 266265024400 Q-loop/lid; other site 266265024401 ABC transporter signature motif; other site 266265024402 Walker B; other site 266265024403 D-loop; other site 266265024404 H-loop/switch region; other site 266265024405 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266265024406 dihydropyrimidinase; Provisional; Region: PRK13404 266265024407 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 266265024408 tetramer interface [polypeptide binding]; other site 266265024409 active site 266265024410 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024411 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024412 trimer interface [polypeptide binding]; other site 266265024413 eyelet of channel; other site 266265024414 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266265024415 Amidase; Region: Amidase; cl11426 266265024416 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 266265024417 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265024418 active site 266265024419 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265024420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265024421 DNA-binding site [nucleotide binding]; DNA binding site 266265024422 FCD domain; Region: FCD; pfam07729 266265024423 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 266265024424 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 266265024425 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265024426 N-terminal plug; other site 266265024427 ligand-binding site [chemical binding]; other site 266265024428 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 266265024429 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 266265024430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265024431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265024432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265024433 dimerization interface [polypeptide binding]; other site 266265024434 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 266265024435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 266265024436 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266265024437 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265024438 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265024439 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265024440 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024441 substrate binding site [chemical binding]; other site 266265024442 oxyanion hole (OAH) forming residues; other site 266265024443 trimer interface [polypeptide binding]; other site 266265024444 Winged helix-turn helix; Region: HTH_29; pfam13551 266265024445 Integrase core domain; Region: rve; pfam00665 266265024446 AAA domain; Region: AAA_22; pfam13401 266265024447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265024448 Walker A motif; other site 266265024449 ATP binding site [chemical binding]; other site 266265024450 Walker B motif; other site 266265024451 arginine finger; other site 266265024452 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265024453 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265024454 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 266265024455 acyl-activating enzyme (AAE) consensus motif; other site 266265024456 acyl-activating enzyme (AAE) consensus motif; other site 266265024457 putative AMP binding site [chemical binding]; other site 266265024458 putative active site [active] 266265024459 putative CoA binding site [chemical binding]; other site 266265024460 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265024461 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265024462 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265024463 classical (c) SDRs; Region: SDR_c; cd05233 266265024464 NAD(P) binding site [chemical binding]; other site 266265024465 active site 266265024466 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265024467 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 266265024468 NAD(P) binding site [chemical binding]; other site 266265024469 catalytic residues [active] 266265024470 flagellin; Validated; Region: PRK08026 266265024471 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265024472 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 266265024473 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266265024474 active site 266265024475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265024476 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265024477 active site 266265024478 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024479 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 266265024480 substrate binding site [chemical binding]; other site 266265024481 oxyanion hole (OAH) forming residues; other site 266265024482 trimer interface [polypeptide binding]; other site 266265024483 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024484 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024485 trimer interface [polypeptide binding]; other site 266265024486 eyelet of channel; other site 266265024487 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 266265024488 Transcriptional regulators [Transcription]; Region: FadR; COG2186 266265024489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265024490 DNA-binding site [nucleotide binding]; DNA binding site 266265024491 FCD domain; Region: FCD; pfam07729 266265024492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266265024493 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265024494 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265024495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265024496 NAD(P) binding site [chemical binding]; other site 266265024497 MarR family; Region: MarR_2; cl17246 266265024498 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265024499 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 266265024500 FAD binding domain; Region: FAD_binding_4; pfam01565 266265024501 NMT1/THI5 like; Region: NMT1; pfam09084 266265024502 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265024503 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265024504 Walker A/P-loop; other site 266265024505 ATP binding site [chemical binding]; other site 266265024506 Q-loop/lid; other site 266265024507 ABC transporter signature motif; other site 266265024508 Walker B; other site 266265024509 D-loop; other site 266265024510 H-loop/switch region; other site 266265024511 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265024512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265024513 dimer interface [polypeptide binding]; other site 266265024514 conserved gate region; other site 266265024515 putative PBP binding loops; other site 266265024516 ABC-ATPase subunit interface; other site 266265024517 cytosine deaminase-like protein; Validated; Region: PRK07583 266265024518 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 266265024519 active site 266265024520 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265024521 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266265024522 FMN-binding pocket [chemical binding]; other site 266265024523 flavin binding motif; other site 266265024524 phosphate binding motif [ion binding]; other site 266265024525 beta-alpha-beta structure motif; other site 266265024526 NAD binding pocket [chemical binding]; other site 266265024527 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265024528 catalytic loop [active] 266265024529 iron binding site [ion binding]; other site 266265024530 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024531 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024532 trimer interface [polypeptide binding]; other site 266265024533 eyelet of channel; other site 266265024534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 266265024535 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 266265024536 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 266265024537 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 266265024538 Helix-turn-helix domain; Region: HTH_28; pfam13518 266265024539 HTH-like domain; Region: HTH_21; pfam13276 266265024540 Integrase core domain; Region: rve; pfam00665 266265024541 Integrase core domain; Region: rve_3; cl15866 266265024542 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 266265024543 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266265024544 active site 266265024545 DNA binding site [nucleotide binding] 266265024546 Int/Topo IB signature motif; other site 266265024547 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265024548 classical (c) SDRs; Region: SDR_c; cd05233 266265024549 NAD(P) binding site [chemical binding]; other site 266265024550 active site 266265024551 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 266265024552 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 266265024553 NADP binding site [chemical binding]; other site 266265024554 substrate binding site [chemical binding]; other site 266265024555 active site 266265024556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265024557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265024558 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 266265024559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265024560 substrate binding pocket [chemical binding]; other site 266265024561 membrane-bound complex binding site; other site 266265024562 hinge residues; other site 266265024563 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 266265024564 dimer interface [polypeptide binding]; other site 266265024565 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265024566 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 266265024567 Putative transposase; Region: Y2_Tnp; pfam04986 266265024568 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 266265024569 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 266265024570 Int/Topo IB signature motif; other site 266265024571 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 266265024572 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 266265024573 putative trimer interface [polypeptide binding]; other site 266265024574 putative CoA binding site [chemical binding]; other site 266265024575 Cupin domain; Region: Cupin_2; cl17218 266265024576 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266265024577 active site 266265024578 Int/Topo IB signature motif; other site 266265024579 DNA binding site [nucleotide binding] 266265024580 benzoate transport; Region: 2A0115; TIGR00895 266265024581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024582 putative substrate translocation pore; other site 266265024583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024584 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024585 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024586 trimer interface [polypeptide binding]; other site 266265024587 eyelet of channel; other site 266265024588 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 266265024589 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265024590 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265024591 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266265024592 putative active site [active] 266265024593 putative catalytic site [active] 266265024594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265024595 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265024596 active site 266265024597 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 266265024598 putative active site [active] 266265024599 putative catalytic site [active] 266265024600 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024601 substrate binding site [chemical binding]; other site 266265024602 oxyanion hole (OAH) forming residues; other site 266265024603 trimer interface [polypeptide binding]; other site 266265024604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265024605 DNA-binding site [nucleotide binding]; DNA binding site 266265024606 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 266265024607 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 266265024608 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 266265024609 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 266265024610 Transposase; Region: DEDD_Tnp_IS110; pfam01548 266265024611 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 266265024612 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024613 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024614 trimer interface [polypeptide binding]; other site 266265024615 eyelet of channel; other site 266265024616 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266265024617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265024618 putative ADP-binding pocket [chemical binding]; other site 266265024619 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 266265024620 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 266265024621 active site 266265024622 homotetramer interface [polypeptide binding]; other site 266265024623 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265024624 HAMP domain; Region: HAMP; pfam00672 266265024625 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265024626 dimer interface [polypeptide binding]; other site 266265024627 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266265024628 putative CheW interface [polypeptide binding]; other site 266265024629 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024630 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024631 trimer interface [polypeptide binding]; other site 266265024632 eyelet of channel; other site 266265024633 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265024634 classical (c) SDRs; Region: SDR_c; cd05233 266265024635 NAD(P) binding site [chemical binding]; other site 266265024636 active site 266265024637 acyl-CoA synthetase; Validated; Region: PRK06145 266265024638 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265024639 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266265024640 acyl-activating enzyme (AAE) consensus motif; other site 266265024641 acyl-activating enzyme (AAE) consensus motif; other site 266265024642 putative AMP binding site [chemical binding]; other site 266265024643 putative active site [active] 266265024644 putative CoA binding site [chemical binding]; other site 266265024645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 266265024646 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 266265024647 active site 266265024648 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 266265024649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265024650 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266265024651 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 266265024652 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 266265024653 E3 interaction surface; other site 266265024654 lipoyl attachment site [posttranslational modification]; other site 266265024655 e3 binding domain; Region: E3_binding; pfam02817 266265024656 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 266265024657 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 266265024658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024659 substrate binding site [chemical binding]; other site 266265024660 oxyanion hole (OAH) forming residues; other site 266265024661 trimer interface [polypeptide binding]; other site 266265024662 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 266265024663 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 266265024664 alpha subunit interface [polypeptide binding]; other site 266265024665 TPP binding site [chemical binding]; other site 266265024666 heterodimer interface [polypeptide binding]; other site 266265024667 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 266265024668 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 266265024669 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 266265024670 tetramer interface [polypeptide binding]; other site 266265024671 TPP-binding site [chemical binding]; other site 266265024672 heterodimer interface [polypeptide binding]; other site 266265024673 phosphorylation loop region [posttranslational modification] 266265024674 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 266265024675 active site 266265024676 catalytic site [active] 266265024677 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 266265024678 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 266265024679 DUF35 OB-fold domain; Region: DUF35; pfam01796 266265024680 thiolase; Provisional; Region: PRK06158 266265024681 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 266265024682 active site 266265024683 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 266265024684 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265024685 putative ligand binding site [chemical binding]; other site 266265024686 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265024687 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265024688 TM-ABC transporter signature motif; other site 266265024689 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265024690 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265024691 TM-ABC transporter signature motif; other site 266265024692 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265024693 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265024694 Walker A/P-loop; other site 266265024695 ATP binding site [chemical binding]; other site 266265024696 Q-loop/lid; other site 266265024697 ABC transporter signature motif; other site 266265024698 Walker B; other site 266265024699 D-loop; other site 266265024700 H-loop/switch region; other site 266265024701 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265024702 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265024703 Walker A/P-loop; other site 266265024704 ATP binding site [chemical binding]; other site 266265024705 Q-loop/lid; other site 266265024706 ABC transporter signature motif; other site 266265024707 Walker B; other site 266265024708 D-loop; other site 266265024709 H-loop/switch region; other site 266265024710 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265024711 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265024712 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265024713 AMP-binding domain protein; Validated; Region: PRK08315 266265024714 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265024715 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 266265024716 acyl-activating enzyme (AAE) consensus motif; other site 266265024717 acyl-activating enzyme (AAE) consensus motif; other site 266265024718 putative AMP binding site [chemical binding]; other site 266265024719 putative active site [active] 266265024720 putative CoA binding site [chemical binding]; other site 266265024721 enoyl-CoA hydratase; Provisional; Region: PRK07658 266265024722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024723 substrate binding site [chemical binding]; other site 266265024724 oxyanion hole (OAH) forming residues; other site 266265024725 trimer interface [polypeptide binding]; other site 266265024726 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265024727 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 266265024728 NAD(P) binding site [chemical binding]; other site 266265024729 active site 266265024730 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 266265024731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265024732 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 266265024733 dimerization interface [polypeptide binding]; other site 266265024734 substrate binding pocket [chemical binding]; other site 266265024735 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 266265024736 putative NAD(P) binding site [chemical binding]; other site 266265024737 putative active site [active] 266265024738 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 266265024739 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 266265024740 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 266265024741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265024742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265024743 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265024744 putative effector binding pocket; other site 266265024745 dimerization interface [polypeptide binding]; other site 266265024746 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 266265024747 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 266265024748 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 266265024749 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 266265024750 shikimate binding site; other site 266265024751 NAD(P) binding site [chemical binding]; other site 266265024752 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024753 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024754 trimer interface [polypeptide binding]; other site 266265024755 eyelet of channel; other site 266265024756 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 266265024757 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 266265024758 DNA binding residues [nucleotide binding] 266265024759 dimer interface [polypeptide binding]; other site 266265024760 putative metal binding site [ion binding]; other site 266265024761 Heavy-metal-associated domain; Region: HMA; pfam00403 266265024762 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 266265024763 lipoprotein signal peptidase; Provisional; Region: PRK14776 266265024764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 266265024765 Transposase; Region: DDE_Tnp_ISL3; pfam01610 266265024766 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 266265024767 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265024768 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265024769 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265024770 enoyl-CoA hydratase; Provisional; Region: PRK05995 266265024771 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024772 substrate binding site [chemical binding]; other site 266265024773 oxyanion hole (OAH) forming residues; other site 266265024774 trimer interface [polypeptide binding]; other site 266265024775 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 266265024776 4Fe-4S binding domain; Region: Fer4; pfam00037 266265024777 4Fe-4S binding domain; Region: Fer4; pfam00037 266265024778 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 266265024779 dimerization interface [polypeptide binding]; other site 266265024780 FAD binding pocket [chemical binding]; other site 266265024781 FAD binding motif [chemical binding]; other site 266265024782 catalytic residues [active] 266265024783 NAD binding pocket [chemical binding]; other site 266265024784 phosphate binding motif [ion binding]; other site 266265024785 beta-alpha-beta structure motif; other site 266265024786 benzoyl-CoA oxygenase, B subunit; Region: benzo_boxB; TIGR03225 266265024787 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 266265024788 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024789 substrate binding site [chemical binding]; other site 266265024790 oxyanion hole (OAH) forming residues; other site 266265024791 trimer interface [polypeptide binding]; other site 266265024792 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024793 substrate binding site [chemical binding]; other site 266265024794 oxyanion hole (OAH) forming residues; other site 266265024795 trimer interface [polypeptide binding]; other site 266265024796 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 266265024797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265024798 non-specific DNA binding site [nucleotide binding]; other site 266265024799 salt bridge; other site 266265024800 sequence-specific DNA binding site [nucleotide binding]; other site 266265024801 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266265024802 ADP binding site [chemical binding]; other site 266265024803 magnesium binding site [ion binding]; other site 266265024804 putative shikimate binding site; other site 266265024805 aldehyde dehydrogenase; Provisional; Region: PRK11903 266265024806 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 266265024807 substrate binding site [chemical binding]; other site 266265024808 dimer interface [polypeptide binding]; other site 266265024809 NADP binding site [chemical binding]; other site 266265024810 catalytic residues [active] 266265024811 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 266265024812 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 266265024813 dimer interface [polypeptide binding]; other site 266265024814 acyl-activating enzyme (AAE) consensus motif; other site 266265024815 putative active site [active] 266265024816 putative AMP binding site [chemical binding]; other site 266265024817 putative CoA binding site [chemical binding]; other site 266265024818 chemical substrate binding site [chemical binding]; other site 266265024819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265024820 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 266265024821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265024822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265024823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265024824 dimerization interface [polypeptide binding]; other site 266265024825 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 266265024826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024827 putative substrate translocation pore; other site 266265024828 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 266265024829 classical (c) SDRs; Region: SDR_c; cd05233 266265024830 NAD(P) binding site [chemical binding]; other site 266265024831 active site 266265024832 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 266265024833 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 266265024834 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265024835 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265024836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265024838 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 266265024839 NAD(P) binding site [chemical binding]; other site 266265024840 active site 266265024841 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265024842 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 266265024843 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 266265024844 benzoate transport; Region: 2A0115; TIGR00895 266265024845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024846 putative substrate translocation pore; other site 266265024847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024848 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024849 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024850 trimer interface [polypeptide binding]; other site 266265024851 eyelet of channel; other site 266265024852 SnoaL-like domain; Region: SnoaL_4; pfam13577 266265024853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265024854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265024855 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 266265024856 substrate binding pocket [chemical binding]; other site 266265024857 dimerization interface [polypeptide binding]; other site 266265024858 HAMP domain; Region: HAMP; pfam00672 266265024859 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265024860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265024861 dimer interface [polypeptide binding]; other site 266265024862 putative CheW interface [polypeptide binding]; other site 266265024863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024864 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265024865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024866 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 266265024867 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 266265024868 dimer interface [polypeptide binding]; other site 266265024869 active site 266265024870 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024871 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024872 trimer interface [polypeptide binding]; other site 266265024873 eyelet of channel; other site 266265024874 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 266265024875 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 266265024876 putative trimer interface [polypeptide binding]; other site 266265024877 putative metal binding site [ion binding]; other site 266265024878 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265024879 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 266265024880 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265024881 acyl-activating enzyme (AAE) consensus motif; other site 266265024882 AMP binding site [chemical binding]; other site 266265024883 active site 266265024884 CoA binding site [chemical binding]; other site 266265024885 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 266265024886 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265024887 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265024888 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266265024889 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 266265024890 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265024891 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265024892 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 266265024893 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265024894 substrate binding site [chemical binding]; other site 266265024895 oxyanion hole (OAH) forming residues; other site 266265024896 trimer interface [polypeptide binding]; other site 266265024897 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 266265024898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265024899 non-specific DNA binding site [nucleotide binding]; other site 266265024900 salt bridge; other site 266265024901 sequence-specific DNA binding site [nucleotide binding]; other site 266265024902 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 266265024903 ADP binding site [chemical binding]; other site 266265024904 magnesium binding site [ion binding]; other site 266265024905 putative shikimate binding site; other site 266265024906 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024907 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024908 trimer interface [polypeptide binding]; other site 266265024909 eyelet of channel; other site 266265024910 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 266265024911 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265024912 Walker A/P-loop; other site 266265024913 ATP binding site [chemical binding]; other site 266265024914 Q-loop/lid; other site 266265024915 ABC transporter signature motif; other site 266265024916 Walker B; other site 266265024917 D-loop; other site 266265024918 H-loop/switch region; other site 266265024919 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265024920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265024921 dimer interface [polypeptide binding]; other site 266265024922 conserved gate region; other site 266265024923 putative PBP binding loops; other site 266265024924 ABC-ATPase subunit interface; other site 266265024925 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 266265024926 substrate binding pocket [chemical binding]; other site 266265024927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 266265024928 membrane-bound complex binding site; other site 266265024929 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 266265024930 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 266265024931 Rhodanese Homology Domain; Region: RHOD; smart00450 266265024932 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 266265024933 active site residue [active] 266265024934 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 266265024935 active site residue [active] 266265024936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265024937 putative substrate translocation pore; other site 266265024938 Flagellar protein YcgR; Region: YcgR_2; pfam12945 266265024939 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 266265024940 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 266265024941 MarR family; Region: MarR_2; pfam12802 266265024942 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265024943 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265024944 trimer interface [polypeptide binding]; other site 266265024945 eyelet of channel; other site 266265024946 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265024947 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265024948 TM-ABC transporter signature motif; other site 266265024949 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265024950 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265024951 TM-ABC transporter signature motif; other site 266265024952 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265024953 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265024954 Walker A/P-loop; other site 266265024955 ATP binding site [chemical binding]; other site 266265024956 Q-loop/lid; other site 266265024957 ABC transporter signature motif; other site 266265024958 Walker B; other site 266265024959 D-loop; other site 266265024960 H-loop/switch region; other site 266265024961 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265024962 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265024963 Walker A/P-loop; other site 266265024964 ATP binding site [chemical binding]; other site 266265024965 Q-loop/lid; other site 266265024966 ABC transporter signature motif; other site 266265024967 Walker B; other site 266265024968 D-loop; other site 266265024969 H-loop/switch region; other site 266265024970 Cupin domain; Region: Cupin_2; pfam07883 266265024971 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266265024972 [2Fe-2S] cluster binding site [ion binding]; other site 266265024973 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265024974 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265024975 iron-sulfur cluster [ion binding]; other site 266265024976 [2Fe-2S] cluster binding site [ion binding]; other site 266265024977 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 266265024978 putative alpha subunit interface [polypeptide binding]; other site 266265024979 putative active site [active] 266265024980 putative substrate binding site [chemical binding]; other site 266265024981 Fe binding site [ion binding]; other site 266265024982 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265024983 inter-subunit interface; other site 266265024984 Cupin domain; Region: Cupin_2; cl17218 266265024985 Cupin domain; Region: Cupin_2; pfam07883 266265024986 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 266265024987 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 266265024988 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 266265024989 Cytochrome P450; Region: p450; cl12078 266265024990 choline dehydrogenase; Validated; Region: PRK02106 266265024991 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265024992 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266265024993 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265024994 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265024995 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265024996 active site 266265024997 catalytic tetrad [active] 266265024998 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265024999 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 266265025000 putative ligand binding site [chemical binding]; other site 266265025001 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 266265025002 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266265025003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265025004 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 266265025005 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 266265025006 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 266265025007 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 266265025008 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 266265025009 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266265025010 tartronate semialdehyde reductase; Provisional; Region: PRK15059 266265025011 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 266265025012 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 266265025013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265025014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265025015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265025016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265025017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265025018 dimerization interface [polypeptide binding]; other site 266265025019 Hemerythrin; Region: Hemerythrin; cd12107 266265025020 Fe binding site [ion binding]; other site 266265025021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265025022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265025023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265025024 dimerization interface [polypeptide binding]; other site 266265025025 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266265025026 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265025027 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266265025028 benzoate transport; Region: 2A0115; TIGR00895 266265025029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025030 putative substrate translocation pore; other site 266265025031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025032 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265025033 classical (c) SDRs; Region: SDR_c; cd05233 266265025034 NAD(P) binding site [chemical binding]; other site 266265025035 active site 266265025036 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265025037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265025038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265025039 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 266265025040 putative dimerization interface [polypeptide binding]; other site 266265025041 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 266265025042 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265025043 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 266265025044 classical (c) SDRs; Region: SDR_c; cd05233 266265025045 NAD(P) binding site [chemical binding]; other site 266265025046 active site 266265025047 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265025048 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265025049 eyelet of channel; other site 266265025050 trimer interface [polypeptide binding]; other site 266265025051 benzoate transport; Region: 2A0115; TIGR00895 266265025052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025053 putative substrate translocation pore; other site 266265025054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025055 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 266265025056 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266265025057 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265025058 active site 266265025059 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265025060 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265025061 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265025062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265025063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265025064 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 266265025065 putative effector binding pocket; other site 266265025066 putative dimerization interface [polypeptide binding]; other site 266265025067 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266265025068 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265025069 putative NAD(P) binding site [chemical binding]; other site 266265025070 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 266265025071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265025072 dimer interface [polypeptide binding]; other site 266265025073 conserved gate region; other site 266265025074 putative PBP binding loops; other site 266265025075 ABC-ATPase subunit interface; other site 266265025076 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 266265025077 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 266265025078 Walker A/P-loop; other site 266265025079 ATP binding site [chemical binding]; other site 266265025080 Q-loop/lid; other site 266265025081 ABC transporter signature motif; other site 266265025082 Walker B; other site 266265025083 D-loop; other site 266265025084 H-loop/switch region; other site 266265025085 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 266265025086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265025087 substrate binding pocket [chemical binding]; other site 266265025088 membrane-bound complex binding site; other site 266265025089 hinge residues; other site 266265025090 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 266265025091 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266265025092 active site 266265025093 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 266265025094 active site 266265025095 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 266265025096 dimer interface [polypeptide binding]; other site 266265025097 non-prolyl cis peptide bond; other site 266265025098 insertion regions; other site 266265025099 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 266265025100 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 266265025101 active site 266265025102 oxalacetate binding site [chemical binding]; other site 266265025103 citrylCoA binding site [chemical binding]; other site 266265025104 coenzyme A binding site [chemical binding]; other site 266265025105 catalytic triad [active] 266265025106 acyl-CoA synthetase; Validated; Region: PRK06188 266265025107 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265025108 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 266265025109 acyl-activating enzyme (AAE) consensus motif; other site 266265025110 putative AMP binding site [chemical binding]; other site 266265025111 putative active site [active] 266265025112 putative CoA binding site [chemical binding]; other site 266265025113 Uncharacterized conserved protein [Function unknown]; Region: COG2128 266265025114 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 266265025115 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265025116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025117 putative substrate translocation pore; other site 266265025118 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 266265025119 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265025120 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265025121 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265025122 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265025123 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 266265025124 putative active site [active] 266265025125 putative metal binding site [ion binding]; other site 266265025126 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 266265025127 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265025128 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265025129 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 266265025130 fumarylacetoacetase; Region: PLN02856 266265025131 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 266265025132 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265025133 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 266265025134 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265025135 TM-ABC transporter signature motif; other site 266265025136 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265025137 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265025138 TM-ABC transporter signature motif; other site 266265025139 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265025140 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265025141 Walker A/P-loop; other site 266265025142 ATP binding site [chemical binding]; other site 266265025143 Q-loop/lid; other site 266265025144 ABC transporter signature motif; other site 266265025145 Walker B; other site 266265025146 D-loop; other site 266265025147 H-loop/switch region; other site 266265025148 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265025149 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265025150 Walker A/P-loop; other site 266265025151 ATP binding site [chemical binding]; other site 266265025152 Q-loop/lid; other site 266265025153 ABC transporter signature motif; other site 266265025154 Walker B; other site 266265025155 D-loop; other site 266265025156 H-loop/switch region; other site 266265025157 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 266265025158 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 266265025159 FMN-binding pocket [chemical binding]; other site 266265025160 flavin binding motif; other site 266265025161 phosphate binding motif [ion binding]; other site 266265025162 beta-alpha-beta structure motif; other site 266265025163 NAD binding pocket [chemical binding]; other site 266265025164 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265025165 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 266265025166 catalytic loop [active] 266265025167 iron binding site [ion binding]; other site 266265025168 SnoaL-like domain; Region: SnoaL_3; pfam13474 266265025169 SnoaL-like domain; Region: SnoaL_2; pfam12680 266265025170 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 266265025171 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 266265025172 putative active site [active] 266265025173 putative metal binding site [ion binding]; other site 266265025174 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265025175 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 266265025176 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 266265025177 putative ligand binding site [chemical binding]; other site 266265025178 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265025179 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266265025180 NAD(P) binding site [chemical binding]; other site 266265025181 catalytic residues [active] 266265025182 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 266265025183 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 266265025184 active site 266265025185 catalytic tetrad [active] 266265025186 hypothetical protein; Provisional; Region: PRK06126 266265025187 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265025188 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265025189 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 266265025190 [2Fe-2S] cluster binding site [ion binding]; other site 266265025191 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 266265025192 alpha subunit interface [polypeptide binding]; other site 266265025193 active site 266265025194 substrate binding site [chemical binding]; other site 266265025195 Fe binding site [ion binding]; other site 266265025196 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 266265025197 dimer interface [polypeptide binding]; other site 266265025198 active site 266265025199 coenzyme A binding site [chemical binding]; other site 266265025200 citrylCoA binding site [chemical binding]; other site 266265025201 Citrate synthase; Region: Citrate_synt; pfam00285 266265025202 oxalacetate/citrate binding site [chemical binding]; other site 266265025203 catalytic triad [active] 266265025204 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265025205 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265025206 iron-sulfur cluster [ion binding]; other site 266265025207 [2Fe-2S] cluster binding site [ion binding]; other site 266265025208 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 266265025209 alpha subunit interface [polypeptide binding]; other site 266265025210 active site 266265025211 substrate binding site [chemical binding]; other site 266265025212 Fe binding site [ion binding]; other site 266265025213 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 266265025214 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265025215 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265025216 trimer interface [polypeptide binding]; other site 266265025217 eyelet of channel; other site 266265025218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 266265025219 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 266265025220 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 266265025221 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 266265025222 Amidohydrolase; Region: Amidohydro_2; pfam04909 266265025223 active site 266265025224 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 266265025225 salicylate hydroxylase; Provisional; Region: PRK08163 266265025226 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 266265025227 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 266265025228 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 266265025229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265025230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265025231 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 266265025232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265025233 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 266265025234 acyl-activating enzyme (AAE) consensus motif; other site 266265025235 acyl-activating enzyme (AAE) consensus motif; other site 266265025236 AMP binding site [chemical binding]; other site 266265025237 active site 266265025238 CoA binding site [chemical binding]; other site 266265025239 benzoate transport; Region: 2A0115; TIGR00895 266265025240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025241 putative substrate translocation pore; other site 266265025242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025243 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265025244 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265025245 trimer interface [polypeptide binding]; other site 266265025246 eyelet of channel; other site 266265025247 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 266265025248 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 266265025249 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265025250 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 266265025251 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 266265025252 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265025253 substrate binding site [chemical binding]; other site 266265025254 oxyanion hole (OAH) forming residues; other site 266265025255 trimer interface [polypeptide binding]; other site 266265025256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 266265025257 substrate binding site [chemical binding]; other site 266265025258 oxyanion hole (OAH) forming residues; other site 266265025259 trimer interface [polypeptide binding]; other site 266265025260 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265025261 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265025262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025263 metabolite-proton symporter; Region: 2A0106; TIGR00883 266265025264 putative substrate translocation pore; other site 266265025265 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 266265025266 CoA-transferase family III; Region: CoA_transf_3; pfam02515 266265025267 Coenzyme A transferase; Region: CoA_trans; cl17247 266265025268 Coenzyme A transferase; Region: CoA_trans; cl17247 266265025269 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 266265025270 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 266265025271 active site 266265025272 Transcriptional regulator [Transcription]; Region: IclR; COG1414 266265025273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265025274 putative DNA binding site [nucleotide binding]; other site 266265025275 putative Zn2+ binding site [ion binding]; other site 266265025276 Bacterial transcriptional regulator; Region: IclR; pfam01614 266265025277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265025278 NAD(P) binding site [chemical binding]; other site 266265025279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 266265025280 active site 266265025281 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 266265025282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265025283 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 266265025284 dimerization interface [polypeptide binding]; other site 266265025285 substrate binding pocket [chemical binding]; other site 266265025286 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 266265025287 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 266265025288 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 266265025289 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 266265025290 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 266265025291 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 266265025292 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 266265025293 N-terminal plug; other site 266265025294 ligand-binding site [chemical binding]; other site 266265025295 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 266265025296 FecR protein; Region: FecR; pfam04773 266265025297 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 266265025298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 266265025299 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 266265025300 DNA binding residues [nucleotide binding] 266265025301 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 266265025302 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 266265025303 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 266265025304 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 266265025305 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 266265025306 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 266265025307 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265025308 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 266265025309 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265025310 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265025311 trimer interface [polypeptide binding]; other site 266265025312 eyelet of channel; other site 266265025313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025314 putative substrate translocation pore; other site 266265025315 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266265025316 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 266265025317 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266265025318 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266265025319 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266265025320 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 266265025321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265025322 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 266265025323 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 266265025324 dimer interface [polypeptide binding]; other site 266265025325 TPP-binding site [chemical binding]; other site 266265025326 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 266265025327 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 266265025328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 266265025329 putative DNA binding site [nucleotide binding]; other site 266265025330 putative Zn2+ binding site [ion binding]; other site 266265025331 AsnC family; Region: AsnC_trans_reg; pfam01037 266265025332 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 266265025333 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 266265025334 metal binding site [ion binding]; metal-binding site 266265025335 active site 266265025336 I-site; other site 266265025337 Cache domain; Region: Cache_1; pfam02743 266265025338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265025339 dimerization interface [polypeptide binding]; other site 266265025340 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265025341 dimer interface [polypeptide binding]; other site 266265025342 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 266265025343 putative CheW interface [polypeptide binding]; other site 266265025344 Homeodomain-like domain; Region: HTH_23; cl17451 266265025345 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 266265025346 dimerization interface [polypeptide binding]; other site 266265025347 substrate binding site [chemical binding]; other site 266265025348 active site 266265025349 calcium binding site [ion binding]; other site 266265025350 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 266265025351 nudix motif; other site 266265025352 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 266265025353 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 266265025354 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 266265025355 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 266265025356 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266265025357 putative glycosyl transferase; Provisional; Region: PRK10307 266265025358 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 266265025359 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 266265025360 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 266265025361 putative metal binding site; other site 266265025362 putative acyl transferase; Provisional; Region: PRK10502 266265025363 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 266265025364 putative trimer interface [polypeptide binding]; other site 266265025365 putative active site [active] 266265025366 putative substrate binding site [chemical binding]; other site 266265025367 putative CoA binding site [chemical binding]; other site 266265025368 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 266265025369 trimer interface [polypeptide binding]; other site 266265025370 active site 266265025371 substrate binding site [chemical binding]; other site 266265025372 CoA binding site [chemical binding]; other site 266265025373 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265025374 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265025375 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 266265025376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265025377 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 266265025378 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265025379 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 266265025380 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 266265025381 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 266265025382 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 266265025383 NADP binding site [chemical binding]; other site 266265025384 active site 266265025385 putative substrate binding site [chemical binding]; other site 266265025386 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 266265025387 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 266265025388 NADP-binding site; other site 266265025389 homotetramer interface [polypeptide binding]; other site 266265025390 substrate binding site [chemical binding]; other site 266265025391 homodimer interface [polypeptide binding]; other site 266265025392 active site 266265025393 tyrosine kinase; Provisional; Region: PRK11519 266265025394 Chain length determinant protein; Region: Wzz; pfam02706 266265025395 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 266265025396 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 266265025397 Low molecular weight phosphatase family; Region: LMWPc; cd00115 266265025398 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 266265025399 active site 266265025400 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 266265025401 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 266265025402 SLBB domain; Region: SLBB; pfam10531 266265025403 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 266265025404 Bacterial sugar transferase; Region: Bac_transf; pfam02397 266265025405 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 266265025406 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 266265025407 Substrate binding site; other site 266265025408 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 266265025409 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 266265025410 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265025411 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266265025412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265025413 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 266265025414 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 266265025415 active site 266265025416 tetramer interface; other site 266265025417 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 266265025418 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266265025419 conserved cys residue [active] 266265025420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265025421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265025422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265025423 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265025424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265025425 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 266265025426 DDE domain; Region: DDE_Tnp_IS240; pfam13610 266265025427 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266265025428 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 266265025429 NAD(P) binding site [chemical binding]; other site 266265025430 catalytic residues [active] 266265025431 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265025432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265025433 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 266265025434 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 266265025435 Flavoprotein; Region: Flavoprotein; pfam02441 266265025436 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265025437 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 266265025438 TM-ABC transporter signature motif; other site 266265025439 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 266265025440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265025441 Walker A/P-loop; other site 266265025442 ATP binding site [chemical binding]; other site 266265025443 Q-loop/lid; other site 266265025444 ABC transporter signature motif; other site 266265025445 Walker B; other site 266265025446 D-loop; other site 266265025447 H-loop/switch region; other site 266265025448 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 266265025449 zinc binding site [ion binding]; other site 266265025450 putative ligand binding site [chemical binding]; other site 266265025451 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 266265025452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 266265025453 thiamine pyrophosphate protein; Validated; Region: PRK08199 266265025454 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265025455 PYR/PP interface [polypeptide binding]; other site 266265025456 dimer interface [polypeptide binding]; other site 266265025457 TPP binding site [chemical binding]; other site 266265025458 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265025459 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266265025460 TPP-binding site [chemical binding]; other site 266265025461 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265025462 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265025463 trimer interface [polypeptide binding]; other site 266265025464 eyelet of channel; other site 266265025465 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 266265025466 zinc binding site [ion binding]; other site 266265025467 putative ligand binding site [chemical binding]; other site 266265025468 hypothetical protein; Provisional; Region: PRK07475 266265025469 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266265025470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265025471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265025472 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266265025473 [2Fe-2S] cluster binding site [ion binding]; other site 266265025474 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265025475 inter-subunit interface; other site 266265025476 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 266265025477 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 266265025478 putative alpha subunit interface [polypeptide binding]; other site 266265025479 putative active site [active] 266265025480 putative substrate binding site [chemical binding]; other site 266265025481 Fe binding site [ion binding]; other site 266265025482 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 266265025483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265025484 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265025485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265025486 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 266265025487 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 266265025488 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 266265025489 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 266265025490 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 266265025491 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 266265025492 Surface antigen; Region: Bac_surface_Ag; pfam01103 266265025493 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 266265025494 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 266265025495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265025496 substrate binding pocket [chemical binding]; other site 266265025497 membrane-bound complex binding site; other site 266265025498 hinge residues; other site 266265025499 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265025500 active site residue [active] 266265025501 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 266265025502 active site residue [active] 266265025503 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265025504 active site residue [active] 266265025505 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 266265025506 active site residue [active] 266265025507 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 266265025508 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 266265025509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 266265025510 catalytic residue [active] 266265025511 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 266265025512 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265025513 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265025514 Walker A/P-loop; other site 266265025515 ATP binding site [chemical binding]; other site 266265025516 Q-loop/lid; other site 266265025517 ABC transporter signature motif; other site 266265025518 Walker B; other site 266265025519 D-loop; other site 266265025520 H-loop/switch region; other site 266265025521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265025522 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265025523 substrate binding pocket [chemical binding]; other site 266265025524 membrane-bound complex binding site; other site 266265025525 hinge residues; other site 266265025526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265025527 dimer interface [polypeptide binding]; other site 266265025528 conserved gate region; other site 266265025529 putative PBP binding loops; other site 266265025530 ABC-ATPase subunit interface; other site 266265025531 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265025532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265025533 dimer interface [polypeptide binding]; other site 266265025534 conserved gate region; other site 266265025535 putative PBP binding loops; other site 266265025536 ABC-ATPase subunit interface; other site 266265025537 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265025538 Cache domain; Region: Cache_1; pfam02743 266265025539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 266265025540 dimerization interface [polypeptide binding]; other site 266265025541 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 266265025542 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 266265025543 dimer interface [polypeptide binding]; other site 266265025544 putative CheW interface [polypeptide binding]; other site 266265025545 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 266265025546 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 266265025547 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265025548 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 266265025549 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 266265025550 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 266265025551 putative active site [active] 266265025552 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 266265025553 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 266265025554 Walker A/P-loop; other site 266265025555 ATP binding site [chemical binding]; other site 266265025556 Q-loop/lid; other site 266265025557 ABC transporter signature motif; other site 266265025558 Walker B; other site 266265025559 D-loop; other site 266265025560 H-loop/switch region; other site 266265025561 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 266265025562 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 266265025563 HlyD family secretion protein; Region: HlyD_3; pfam13437 266265025564 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 266265025565 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266265025566 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266265025567 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 266265025568 PapC N-terminal domain; Region: PapC_N; pfam13954 266265025569 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 266265025570 PapC C-terminal domain; Region: PapC_C; pfam13953 266265025571 putative chaperone protein EcpD; Provisional; Region: PRK09926 266265025572 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 266265025573 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 266265025574 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 266265025575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 266265025576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265025577 active site 266265025578 phosphorylation site [posttranslational modification] 266265025579 intermolecular recognition site; other site 266265025580 dimerization interface [polypeptide binding]; other site 266265025581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 266265025582 DNA binding residues [nucleotide binding] 266265025583 dimerization interface [polypeptide binding]; other site 266265025584 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265025585 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265025586 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265025587 Walker A/P-loop; other site 266265025588 ATP binding site [chemical binding]; other site 266265025589 Q-loop/lid; other site 266265025590 ABC transporter signature motif; other site 266265025591 Walker B; other site 266265025592 D-loop; other site 266265025593 H-loop/switch region; other site 266265025594 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265025595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265025596 dimer interface [polypeptide binding]; other site 266265025597 conserved gate region; other site 266265025598 putative PBP binding loops; other site 266265025599 ABC-ATPase subunit interface; other site 266265025600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265025601 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265025602 substrate binding pocket [chemical binding]; other site 266265025603 membrane-bound complex binding site; other site 266265025604 hinge residues; other site 266265025605 thiamine pyrophosphate protein; Validated; Region: PRK08199 266265025606 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 266265025607 PYR/PP interface [polypeptide binding]; other site 266265025608 dimer interface [polypeptide binding]; other site 266265025609 TPP binding site [chemical binding]; other site 266265025610 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265025611 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 266265025612 TPP-binding site [chemical binding]; other site 266265025613 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265025614 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 266265025615 NAD(P) binding site [chemical binding]; other site 266265025616 catalytic residues [active] 266265025617 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 266265025618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265025619 DNA-binding site [nucleotide binding]; DNA binding site 266265025620 UTRA domain; Region: UTRA; pfam07702 266265025621 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 266265025622 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 266265025623 Flavoprotein; Region: Flavoprotein; pfam02441 266265025624 hypothetical protein; Provisional; Region: PRK07475 266265025625 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 266265025626 hydroxyglutarate oxidase; Provisional; Region: PRK11728 266265025627 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265025628 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 266265025629 Integrase core domain; Region: rve; pfam00665 266265025630 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 266265025631 Bacterial TniB protein; Region: TniB; pfam05621 266265025632 TniQ; Region: TniQ; pfam06527 266265025633 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 266265025634 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266265025635 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266265025636 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 266265025637 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 266265025638 nucleophile elbow; other site 266265025639 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 266265025640 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 266265025641 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 266265025642 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 266265025643 active site 266265025644 Int/Topo IB signature motif; other site 266265025645 DNA binding site [nucleotide binding] 266265025646 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 266265025647 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 266265025648 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 266265025649 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 266265025650 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 266265025651 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 266265025652 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 266265025653 active site 266265025654 catalytic residues [active] 266265025655 metal binding site [ion binding]; metal-binding site 266265025656 DmpG-like communication domain; Region: DmpG_comm; pfam07836 266265025657 acetaldehyde dehydrogenase; Validated; Region: PRK08300 266265025658 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 266265025659 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 266265025660 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 266265025661 glutathionine S-transferase; Provisional; Region: PRK10542 266265025662 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 266265025663 C-terminal domain interface [polypeptide binding]; other site 266265025664 GSH binding site (G-site) [chemical binding]; other site 266265025665 dimer interface [polypeptide binding]; other site 266265025666 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 266265025667 dimer interface [polypeptide binding]; other site 266265025668 N-terminal domain interface [polypeptide binding]; other site 266265025669 substrate binding pocket (H-site) [chemical binding]; other site 266265025670 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 266265025671 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 266265025672 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 266265025673 active site 266265025674 Fe binding site [ion binding]; other site 266265025675 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase; Region: BphB_TodD; TIGR03325 266265025676 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 266265025677 NAD binding site [chemical binding]; other site 266265025678 active site 266265025679 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 266265025680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265025681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265025682 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 266265025683 [2Fe-2S] cluster binding site [ion binding]; other site 266265025684 BphX-like; Region: BphX; pfam06139 266265025685 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 266265025686 inter-subunit interface; other site 266265025687 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265025688 iron-sulfur cluster [ion binding]; other site 266265025689 [2Fe-2S] cluster binding site [ion binding]; other site 266265025690 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 266265025691 beta subunit interface [polypeptide binding]; other site 266265025692 alpha subunit interface [polypeptide binding]; other site 266265025693 active site 266265025694 substrate binding site [chemical binding]; other site 266265025695 Fe binding site [ion binding]; other site 266265025696 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265025697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265025698 DNA-binding site [nucleotide binding]; DNA binding site 266265025699 FCD domain; Region: FCD; pfam07729 266265025700 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 266265025701 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 266265025702 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 266265025703 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 266265025704 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 266265025705 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 266265025706 active site residue [active] 266265025707 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 266265025708 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 266265025709 Chromate transporter; Region: Chromate_transp; pfam02417 266265025710 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 266265025711 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 266265025712 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266265025713 Presynaptic Site I dimer interface [polypeptide binding]; other site 266265025714 catalytic residues [active] 266265025715 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266265025716 Synaptic Flat tetramer interface [polypeptide binding]; other site 266265025717 Synaptic Site I dimer interface [polypeptide binding]; other site 266265025718 DNA binding site [nucleotide binding] 266265025719 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 266265025720 DNA-binding interface [nucleotide binding]; DNA binding site 266265025721 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 266265025722 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 266265025723 putative mercury resistance protein; Provisional; Region: PRK13747 266265025724 transcriptional regulator MerD; Provisional; Region: PRK13749 266265025725 Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111 266265025726 DNA binding residues [nucleotide binding] 266265025727 putative dimer interface [polypeptide binding]; other site 266265025728 putative mercuric reductase; Provisional; Region: PRK13748 266265025729 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266265025730 metal-binding site [ion binding] 266265025731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265025732 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 266265025733 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 266265025734 putative mercury transport protein MerC; Provisional; Region: PRK13755 266265025735 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 266265025736 metal-binding site [ion binding] 266265025737 putative mercuric transport protein; Provisional; Region: PRK13751 266265025738 putative transcriptional regulator MerR; Provisional; Region: PRK13752 266265025739 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 266265025740 DNA binding residues [nucleotide binding] 266265025741 dimer interface [polypeptide binding]; other site 266265025742 mercury binding site [ion binding]; other site 266265025743 multiple promoter invertase; Provisional; Region: mpi; PRK13413 266265025744 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 266265025745 catalytic residues [active] 266265025746 catalytic nucleophile [active] 266265025747 Presynaptic Site I dimer interface [polypeptide binding]; other site 266265025748 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 266265025749 Synaptic Flat tetramer interface [polypeptide binding]; other site 266265025750 Synaptic Site I dimer interface [polypeptide binding]; other site 266265025751 Proteins containing SET domain [General function prediction only]; Region: COG2940 266265025752 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 266265025753 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 266265025754 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 266265025755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 266265025756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 266265025757 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 266265025758 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 266265025759 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 266265025760 catalytic loop [active] 266265025761 iron binding site [ion binding]; other site 266265025762 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 266265025763 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 266265025764 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 266265025765 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 266265025766 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 266265025767 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 266265025768 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 266265025769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025770 D-galactonate transporter; Region: 2A0114; TIGR00893 266265025771 putative substrate translocation pore; other site 266265025772 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 266265025773 tartrate dehydrogenase; Region: TTC; TIGR02089 266265025774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265025775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265025776 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265025777 dimerization interface [polypeptide binding]; other site 266265025778 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265025779 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265025780 trimer interface [polypeptide binding]; other site 266265025781 eyelet of channel; other site 266265025782 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265025783 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265025784 trimer interface [polypeptide binding]; other site 266265025785 eyelet of channel; other site 266265025786 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266265025787 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265025788 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266265025789 putative active site [active] 266265025790 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 266265025791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265025792 Walker A/P-loop; other site 266265025793 ATP binding site [chemical binding]; other site 266265025794 Q-loop/lid; other site 266265025795 ABC transporter signature motif; other site 266265025796 Walker B; other site 266265025797 D-loop; other site 266265025798 H-loop/switch region; other site 266265025799 TOBE domain; Region: TOBE_2; pfam08402 266265025800 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 266265025801 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 266265025802 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 266265025803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265025804 dimer interface [polypeptide binding]; other site 266265025805 conserved gate region; other site 266265025806 putative PBP binding loops; other site 266265025807 ABC-ATPase subunit interface; other site 266265025808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265025809 dimer interface [polypeptide binding]; other site 266265025810 conserved gate region; other site 266265025811 putative PBP binding loops; other site 266265025812 ABC-ATPase subunit interface; other site 266265025813 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 266265025814 PHP domain; Region: PHP; pfam02811 266265025815 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 266265025816 active site 266265025817 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 266265025818 Eukaryotic Mediator 12 subunit domain; Region: Med12-LCEWAV; pfam12145 266265025819 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 266265025820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265025822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265025823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265025824 dimerization interface [polypeptide binding]; other site 266265025825 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 266265025826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265025827 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 266265025828 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 266265025829 Flavin binding site [chemical binding]; other site 266265025830 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 266265025831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 266265025832 Walker A motif; other site 266265025833 ATP binding site [chemical binding]; other site 266265025834 Walker B motif; other site 266265025835 arginine finger; other site 266265025836 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265025837 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265025838 trimer interface [polypeptide binding]; other site 266265025839 eyelet of channel; other site 266265025840 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266265025841 Amidase; Region: Amidase; pfam01425 266265025842 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265025843 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265025844 Walker A/P-loop; other site 266265025845 ATP binding site [chemical binding]; other site 266265025846 Q-loop/lid; other site 266265025847 ABC transporter signature motif; other site 266265025848 Walker B; other site 266265025849 D-loop; other site 266265025850 H-loop/switch region; other site 266265025851 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265025852 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265025853 Walker A/P-loop; other site 266265025854 ATP binding site [chemical binding]; other site 266265025855 Q-loop/lid; other site 266265025856 ABC transporter signature motif; other site 266265025857 Walker B; other site 266265025858 D-loop; other site 266265025859 H-loop/switch region; other site 266265025860 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265025861 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 266265025862 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265025863 TM-ABC transporter signature motif; other site 266265025864 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265025865 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 266265025866 ligand binding site [chemical binding]; other site 266265025867 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265025868 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265025869 TM-ABC transporter signature motif; other site 266265025870 TIR domain; Region: TIR_2; pfam13676 266265025871 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 266265025872 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 266265025873 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265025874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265025875 putative substrate translocation pore; other site 266265025876 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 266265025877 cyclase homology domain; Region: CHD; cd07302 266265025878 nucleotidyl binding site; other site 266265025879 metal binding site [ion binding]; metal-binding site 266265025880 dimer interface [polypeptide binding]; other site 266265025881 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 266265025882 nudix motif; other site 266265025883 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 266265025884 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 266265025885 dimerization interface [polypeptide binding]; other site 266265025886 NAD binding site [chemical binding]; other site 266265025887 ligand binding site [chemical binding]; other site 266265025888 catalytic site [active] 266265025889 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 266265025890 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 266265025891 putative NAD(P) binding site [chemical binding]; other site 266265025892 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 266265025893 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 266265025894 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 266265025895 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265025896 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265025897 TM-ABC transporter signature motif; other site 266265025898 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265025899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 266265025900 Walker A/P-loop; other site 266265025901 ATP binding site [chemical binding]; other site 266265025902 Q-loop/lid; other site 266265025903 ABC transporter signature motif; other site 266265025904 Walker B; other site 266265025905 D-loop; other site 266265025906 H-loop/switch region; other site 266265025907 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265025908 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 266265025909 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 266265025910 ligand binding site [chemical binding]; other site 266265025911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265025912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265025913 TM-ABC transporter signature motif; other site 266265025914 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265025915 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 266265025916 substrate binding site [chemical binding]; other site 266265025917 dimer interface [polypeptide binding]; other site 266265025918 ATP binding site [chemical binding]; other site 266265025919 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 266265025920 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265025921 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266265025922 NAD(P) binding site [chemical binding]; other site 266265025923 catalytic residues [active] 266265025924 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 266265025925 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 266265025926 NAD(P) binding site [chemical binding]; other site 266265025927 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 266265025928 intersubunit interface [polypeptide binding]; other site 266265025929 active site 266265025930 catalytic residue [active] 266265025931 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 266265025932 Autotransporter beta-domain; Region: Autotransporter; smart00869 266265025933 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 266265025934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265025935 putative active site [active] 266265025936 heme pocket [chemical binding]; other site 266265025937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 266265025938 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 266265025939 putative active site [active] 266265025940 heme pocket [chemical binding]; other site 266265025941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265025942 dimer interface [polypeptide binding]; other site 266265025943 phosphorylation site [posttranslational modification] 266265025944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265025945 ATP binding site [chemical binding]; other site 266265025946 Mg2+ binding site [ion binding]; other site 266265025947 G-X-G motif; other site 266265025948 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 266265025949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265025950 active site 266265025951 phosphorylation site [posttranslational modification] 266265025952 intermolecular recognition site; other site 266265025953 dimerization interface [polypeptide binding]; other site 266265025954 Response regulator receiver domain; Region: Response_reg; pfam00072 266265025955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265025956 active site 266265025957 phosphorylation site [posttranslational modification] 266265025958 intermolecular recognition site; other site 266265025959 dimerization interface [polypeptide binding]; other site 266265025960 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 266265025961 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266265025962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265025963 S-adenosylmethionine binding site [chemical binding]; other site 266265025964 Erythromycin esterase; Region: Erythro_esteras; pfam05139 266265025965 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 266265025966 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 266265025967 putative ADP-binding pocket [chemical binding]; other site 266265025968 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 266265025969 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 266265025970 substrate binding site [chemical binding]; other site 266265025971 ATP binding site [chemical binding]; other site 266265025972 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 266265025973 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 266265025974 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 266265025975 thiamine pyrophosphate protein; Provisional; Region: PRK08273 266265025976 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 266265025977 PYR/PP interface [polypeptide binding]; other site 266265025978 dimer interface [polypeptide binding]; other site 266265025979 tetramer interface [polypeptide binding]; other site 266265025980 TPP binding site [chemical binding]; other site 266265025981 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 266265025982 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 266265025983 TPP-binding site [chemical binding]; other site 266265025984 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 266265025985 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266265025986 putative active site pocket [active] 266265025987 putative metal binding site [ion binding]; other site 266265025988 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 266265025989 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 266265025990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 266265025991 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 266265025992 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 266265025993 putative catalytic site [active] 266265025994 putative metal binding site [ion binding]; other site 266265025995 putative phosphate binding site [ion binding]; other site 266265025996 putative catalytic site [active] 266265025997 putative phosphate binding site [ion binding]; other site 266265025998 putative metal binding site [ion binding]; other site 266265025999 Tannase and feruloyl esterase; Region: Tannase; pfam07519 266265026000 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 266265026001 Transcriptional regulators [Transcription]; Region: GntR; COG1802 266265026002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 266265026003 DNA-binding site [nucleotide binding]; DNA binding site 266265026004 FCD domain; Region: FCD; pfam07729 266265026005 cystine transporter subunit; Provisional; Region: PRK11260 266265026006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265026007 substrate binding pocket [chemical binding]; other site 266265026008 membrane-bound complex binding site; other site 266265026009 hinge residues; other site 266265026010 Bacterial Ig-like domain; Region: Big_5; pfam13205 266265026011 Bacterial Ig-like domain; Region: Big_5; pfam13205 266265026012 Bacterial Ig-like domain; Region: Big_5; pfam13205 266265026013 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 266265026014 RibD C-terminal domain; Region: RibD_C; cl17279 266265026015 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 266265026016 ANTAR domain; Region: ANTAR; pfam03861 266265026017 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265026018 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 266265026019 ligand binding site [chemical binding]; other site 266265026020 regulator interaction site; other site 266265026021 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 266265026022 Amidase; Region: Amidase; cl11426 266265026023 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 266265026024 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 266265026025 Walker A/P-loop; other site 266265026026 ATP binding site [chemical binding]; other site 266265026027 Q-loop/lid; other site 266265026028 ABC transporter signature motif; other site 266265026029 Walker B; other site 266265026030 D-loop; other site 266265026031 H-loop/switch region; other site 266265026032 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 266265026033 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 266265026034 TM-ABC transporter signature motif; other site 266265026035 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 266265026036 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 266265026037 Walker A/P-loop; other site 266265026038 ATP binding site [chemical binding]; other site 266265026039 Q-loop/lid; other site 266265026040 ABC transporter signature motif; other site 266265026041 Walker B; other site 266265026042 D-loop; other site 266265026043 H-loop/switch region; other site 266265026044 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265026045 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 266265026046 TM-ABC transporter signature motif; other site 266265026047 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 266265026048 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 266265026049 putative ligand binding site [chemical binding]; other site 266265026050 Predicted amidohydrolase [General function prediction only]; Region: COG0388 266265026051 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 266265026052 putative active site [active] 266265026053 catalytic triad [active] 266265026054 putative dimer interface [polypeptide binding]; other site 266265026055 acetylornithine deacetylase; Provisional; Region: PRK07522 266265026056 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 266265026057 metal binding site [ion binding]; metal-binding site 266265026058 putative dimer interface [polypeptide binding]; other site 266265026059 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 266265026060 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 266265026061 trimer interface [polypeptide binding]; other site 266265026062 eyelet of channel; other site 266265026063 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265026064 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265026065 Walker A/P-loop; other site 266265026066 ATP binding site [chemical binding]; other site 266265026067 Q-loop/lid; other site 266265026068 ABC transporter signature motif; other site 266265026069 Walker B; other site 266265026070 D-loop; other site 266265026071 H-loop/switch region; other site 266265026072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265026073 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265026074 substrate binding pocket [chemical binding]; other site 266265026075 membrane-bound complex binding site; other site 266265026076 hinge residues; other site 266265026077 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265026078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265026079 dimer interface [polypeptide binding]; other site 266265026080 conserved gate region; other site 266265026081 putative PBP binding loops; other site 266265026082 ABC-ATPase subunit interface; other site 266265026083 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 266265026084 intracellular protease, PfpI family; Region: PfpI; TIGR01382 266265026085 proposed catalytic triad [active] 266265026086 conserved cys residue [active] 266265026087 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 266265026088 active site 266265026089 substrate binding pocket [chemical binding]; other site 266265026090 homodimer interaction site [polypeptide binding]; other site 266265026091 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 266265026092 conserved cys residue [active] 266265026093 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265026094 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265026095 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 266265026096 dimerization interface [polypeptide binding]; other site 266265026097 allantoicase; Provisional; Region: PRK13257 266265026098 Allantoicase repeat; Region: Allantoicase; pfam03561 266265026099 Allantoicase repeat; Region: Allantoicase; pfam03561 266265026100 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 266265026101 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 266265026102 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 266265026103 Walker A/P-loop; other site 266265026104 ATP binding site [chemical binding]; other site 266265026105 Q-loop/lid; other site 266265026106 ABC transporter signature motif; other site 266265026107 Walker B; other site 266265026108 D-loop; other site 266265026109 H-loop/switch region; other site 266265026110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 266265026111 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 266265026112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 266265026113 dimer interface [polypeptide binding]; other site 266265026114 conserved gate region; other site 266265026115 putative PBP binding loops; other site 266265026116 ABC-ATPase subunit interface; other site 266265026117 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 266265026118 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 266265026119 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 266265026120 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 266265026121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 266265026122 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 266265026123 substrate binding pocket [chemical binding]; other site 266265026124 membrane-bound complex binding site; other site 266265026125 hinge residues; other site 266265026126 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 266265026127 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 266265026128 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 266265026129 putative active site [active] 266265026130 Transposase; Region: HTH_Tnp_1; pfam01527 266265026131 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 266265026132 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 266265026133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 266265026134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 266265026135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 266265026136 dimerization interface [polypeptide binding]; other site 266265026137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 266265026138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265026139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 266265026140 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 266265026141 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 266265026142 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 266265026143 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 266265026144 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 266265026145 Putative glucoamylase; Region: Glycoamylase; pfam10091 266265026146 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 266265026147 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 266265026148 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 266265026149 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 266265026150 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 266265026151 putative active site pocket [active] 266265026152 metal binding site [ion binding]; metal-binding site 266265026153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 266265026154 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 266265026155 putative ligand binding site [chemical binding]; other site 266265026156 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 266265026157 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 266265026158 TM-ABC transporter signature motif; other site 266265026159 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 266265026160 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 266265026161 Walker A/P-loop; other site 266265026162 ATP binding site [chemical binding]; other site 266265026163 Q-loop/lid; other site 266265026164 ABC transporter signature motif; other site 266265026165 Walker B; other site 266265026166 D-loop; other site 266265026167 H-loop/switch region; other site 266265026168 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 266265026169 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 266265026170 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 266265026171 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 266265026172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 266265026173 S-adenosylmethionine binding site [chemical binding]; other site 266265026174 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 266265026175 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 266265026176 tetramer interface [polypeptide binding]; other site 266265026177 catalytic Zn binding site [ion binding]; other site 266265026178 NADP binding site [chemical binding]; other site 266265026179 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 266265026180 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 266265026181 NAD(P) binding site [chemical binding]; other site 266265026182 catalytic residues [active] 266265026183 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 266265026184 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 266265026185 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 266265026186 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 266265026187 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 266265026188 classical (c) SDRs; Region: SDR_c; cd05233 266265026189 NAD(P) binding site [chemical binding]; other site 266265026190 active site 266265026191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 266265026192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 266265026193 non-specific DNA binding site [nucleotide binding]; other site 266265026194 salt bridge; other site 266265026195 sequence-specific DNA binding site [nucleotide binding]; other site 266265026196 HipA N-terminal domain; Region: couple_hipA; TIGR03071 266265026197 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 266265026198 HipA-like N-terminal domain; Region: HipA_N; pfam07805 266265026199 HipA-like C-terminal domain; Region: HipA_C; pfam07804 266265026200 Initiator Replication protein; Region: Rep_3; pfam01051 266265026201 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 266265026202 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 266265026203 P-loop; other site 266265026204 Magnesium ion binding site [ion binding]; other site 266265026205 ParB-like nuclease domain; Region: ParB; smart00470 266265026206 Homeodomain-like domain; Region: HTH_32; pfam13565 266265026207 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 266265026208 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 266265026209 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 266265026210 ligand binding site [chemical binding]; other site 266265026211 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 266265026212 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 266265026213 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 266265026214 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 266265026215 ligand binding site [chemical binding]; other site 266265026216 flexible hinge region; other site 266265026217 Acyltransferase family; Region: Acyl_transf_3; pfam01757 266265026218 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 266265026219 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 266265026220 dimerization interface [polypeptide binding]; other site 266265026221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 266265026222 dimer interface [polypeptide binding]; other site 266265026223 phosphorylation site [posttranslational modification] 266265026224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 266265026225 ATP binding site [chemical binding]; other site 266265026226 G-X-G motif; other site 266265026227 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 266265026228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 266265026229 active site 266265026230 phosphorylation site [posttranslational modification] 266265026231 intermolecular recognition site; other site 266265026232 dimerization interface [polypeptide binding]; other site 266265026233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 266265026234 DNA binding site [nucleotide binding] 266265026235 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 266265026236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265026237 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 266265026238 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 266265026239 NADP binding site [chemical binding]; other site 266265026240 active site 266265026241 steroid binding site; other site 266265026242 Cupin; Region: Cupin_6; pfam12852 266265026243 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 266265026244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265026245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 266265026246 PilZ domain; Region: PilZ; pfam07238 266265026247 NMT1-like family; Region: NMT1_2; pfam13379 266265026248 NMT1/THI5 like; Region: NMT1; pfam09084 266265026249 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 266265026250 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 266265026251 iron-sulfur cluster [ion binding]; other site 266265026252 [2Fe-2S] cluster binding site [ion binding]; other site 266265026253 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 266265026254 hydrophobic ligand binding site; other site 266265026255 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 266265026256 putative effector binding pocket; other site 266265026257 dimerization interface [polypeptide binding]; other site 266265026258 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 266265026259 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 266265026260 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 266265026261 catalytic site [active] 266265026262 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 266265026263 SnoaL-like domain; Region: SnoaL_3; pfam13474