-- dump date 20140619_020109 -- class Genbank::misc_feature -- table misc_feature_note -- id note 657324000001 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324000002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324000003 metal binding site [ion binding]; metal-binding site 657324000004 active site 657324000005 I-site; other site 657324000006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657324000007 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 657324000008 ATP binding site [chemical binding]; other site 657324000009 Mg2+ binding site [ion binding]; other site 657324000010 G-X-G motif; other site 657324000011 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657324000012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324000013 active site 657324000014 phosphorylation site [posttranslational modification] 657324000015 intermolecular recognition site; other site 657324000016 dimerization interface [polypeptide binding]; other site 657324000017 LytTr DNA-binding domain; Region: LytTR; smart00850 657324000018 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 657324000019 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324000020 TM-ABC transporter signature motif; other site 657324000021 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 657324000022 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657324000023 putative ligand binding site [chemical binding]; other site 657324000024 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 657324000025 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 657324000026 putative ligand binding site [chemical binding]; other site 657324000027 Response regulator receiver domain; Region: Response_reg; pfam00072 657324000028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324000029 active site 657324000030 phosphorylation site [posttranslational modification] 657324000031 intermolecular recognition site; other site 657324000032 dimerization interface [polypeptide binding]; other site 657324000033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324000034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657324000035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324000036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657324000037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657324000038 dimerization interface [polypeptide binding]; other site 657324000039 Histidine kinase; Region: His_kinase; pfam06580 657324000040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324000041 ATP binding site [chemical binding]; other site 657324000042 Mg2+ binding site [ion binding]; other site 657324000043 G-X-G motif; other site 657324000044 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 657324000045 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657324000046 ligand binding site [chemical binding]; other site 657324000047 CAAX protease self-immunity; Region: Abi; pfam02517 657324000048 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 657324000049 homodimer interface [polypeptide binding]; other site 657324000050 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 657324000051 active site pocket [active] 657324000052 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324000053 active site 657324000054 KMSKS motif; other site 657324000055 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 657324000056 tRNA binding surface [nucleotide binding]; other site 657324000057 anticodon binding site; other site 657324000058 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 657324000059 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324000060 active site 657324000061 HIGH motif; other site 657324000062 nucleotide binding site [chemical binding]; other site 657324000063 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324000064 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 657324000065 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 657324000066 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 657324000067 substrate binding site [chemical binding]; other site 657324000068 oxyanion hole (OAH) forming residues; other site 657324000069 trimer interface [polypeptide binding]; other site 657324000070 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657324000071 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324000072 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324000073 metal binding site [ion binding]; metal-binding site 657324000074 active site 657324000075 I-site; other site 657324000076 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657324000077 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 657324000078 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 657324000079 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 657324000080 Putative motility protein; Region: YjfB_motility; pfam14070 657324000081 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 657324000082 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 657324000083 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 657324000084 heterodimer interface [polypeptide binding]; other site 657324000085 active site 657324000086 FMN binding site [chemical binding]; other site 657324000087 homodimer interface [polypeptide binding]; other site 657324000088 substrate binding site [chemical binding]; other site 657324000089 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 657324000090 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 657324000091 FAD binding pocket [chemical binding]; other site 657324000092 FAD binding motif [chemical binding]; other site 657324000093 phosphate binding motif [ion binding]; other site 657324000094 beta-alpha-beta structure motif; other site 657324000095 NAD binding pocket [chemical binding]; other site 657324000096 Iron coordination center [ion binding]; other site 657324000097 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 657324000098 active site 657324000099 dimer interface [polypeptide binding]; other site 657324000100 dihydroorotase; Validated; Region: pyrC; PRK09357 657324000101 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 657324000102 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 657324000103 active site 657324000104 aspartate kinase; Reviewed; Region: PRK09034 657324000105 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 657324000106 nucleotide binding site [chemical binding]; other site 657324000107 substrate binding site [chemical binding]; other site 657324000108 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 657324000109 allosteric regulatory residue; other site 657324000110 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 657324000111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324000112 ABC transporter signature motif; other site 657324000113 Walker B; other site 657324000114 D-loop; other site 657324000115 H-loop/switch region; other site 657324000116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324000117 Walker A/P-loop; other site 657324000118 ATP binding site [chemical binding]; other site 657324000119 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324000120 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 657324000121 TM-ABC transporter signature motif; other site 657324000122 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 657324000123 zinc binding site [ion binding]; other site 657324000124 putative ligand binding site [chemical binding]; other site 657324000125 Archaeal ATPase; Region: Arch_ATPase; pfam01637 657324000126 AAA ATPase domain; Region: AAA_16; pfam13191 657324000127 MarR family; Region: MarR_2; cl17246 657324000128 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 657324000129 Immunity protein Imm6; Region: Imm6; pfam14434 657324000130 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 657324000131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657324000132 binding surface 657324000133 TPR motif; other site 657324000134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 657324000135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657324000136 binding surface 657324000137 TPR motif; other site 657324000138 Tetratricopeptide repeat; Region: TPR_16; pfam13432 657324000139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657324000140 binding surface 657324000141 TPR motif; other site 657324000142 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 657324000143 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657324000144 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657324000145 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 657324000146 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 657324000147 AAA domain; Region: AAA_31; pfam13614 657324000148 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657324000149 P-loop; other site 657324000150 Magnesium ion binding site [ion binding]; other site 657324000151 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 657324000152 phosphopeptide binding site; other site 657324000153 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 657324000154 Catalytic domain of Protein Kinases; Region: PKc; cd00180 657324000155 active site 657324000156 ATP binding site [chemical binding]; other site 657324000157 substrate binding site [chemical binding]; other site 657324000158 activation loop (A-loop); other site 657324000159 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 657324000160 active site 657324000161 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 657324000162 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 657324000163 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 657324000164 phosphopeptide binding site; other site 657324000165 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 657324000166 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 657324000167 Tetratricopeptide repeat; Region: TPR_16; pfam13432 657324000168 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 657324000169 HicB family; Region: HicB; pfam05534 657324000170 Domain of unknown function DUF21; Region: DUF21; pfam01595 657324000171 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 657324000172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 657324000173 Transporter associated domain; Region: CorC_HlyC; pfam03471 657324000174 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 657324000175 active site 657324000176 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 657324000177 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 657324000178 Uncharacterized conserved protein [Function unknown]; Region: COG2966 657324000179 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 657324000180 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 657324000181 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 657324000182 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 657324000183 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 657324000184 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657324000185 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657324000186 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 657324000187 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 657324000188 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 657324000189 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 657324000190 Ligand binding site [chemical binding]; other site 657324000191 Electron transfer flavoprotein domain; Region: ETF; pfam01012 657324000192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 657324000193 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 657324000194 FAD binding site [chemical binding]; other site 657324000195 homotetramer interface [polypeptide binding]; other site 657324000196 substrate binding pocket [chemical binding]; other site 657324000197 catalytic base [active] 657324000198 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 657324000199 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 657324000200 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 657324000201 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 657324000202 putative acyltransferase; Provisional; Region: PRK05790 657324000203 dimer interface [polypeptide binding]; other site 657324000204 active site 657324000205 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 657324000206 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 657324000207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 657324000208 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 657324000209 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 657324000210 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 657324000211 putative valine binding site [chemical binding]; other site 657324000212 dimer interface [polypeptide binding]; other site 657324000213 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 657324000214 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 657324000215 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 657324000216 PYR/PP interface [polypeptide binding]; other site 657324000217 dimer interface [polypeptide binding]; other site 657324000218 TPP binding site [chemical binding]; other site 657324000219 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 657324000220 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 657324000221 TPP-binding site [chemical binding]; other site 657324000222 dimer interface [polypeptide binding]; other site 657324000223 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 657324000224 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 657324000225 folate binding site [chemical binding]; other site 657324000226 NADP+ binding site [chemical binding]; other site 657324000227 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 657324000228 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 657324000229 dimerization interface [polypeptide binding]; other site 657324000230 active site 657324000231 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 657324000232 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 657324000233 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 657324000234 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657324000235 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 657324000236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324000237 UPF0489 domain; Region: UPF0489; pfam12640 657324000238 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 657324000239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657324000240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657324000241 DNA binding residues [nucleotide binding] 657324000242 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 657324000243 MobA/MobL family; Region: MobA_MobL; pfam03389 657324000244 MobA/MobL family; Region: MobA_MobL; pfam03389 657324000245 CHC2 zinc finger; Region: zf-CHC2; cl17510 657324000246 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 657324000247 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657324000248 active site 657324000249 DNA binding site [nucleotide binding] 657324000250 Int/Topo IB signature motif; other site 657324000251 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 657324000252 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 657324000253 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324000254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324000255 non-specific DNA binding site [nucleotide binding]; other site 657324000256 salt bridge; other site 657324000257 sequence-specific DNA binding site [nucleotide binding]; other site 657324000258 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 657324000259 putative active site [active] 657324000260 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 657324000261 dimer interface [polypeptide binding]; other site 657324000262 ADP-ribose binding site [chemical binding]; other site 657324000263 active site 657324000264 nudix motif; other site 657324000265 metal binding site [ion binding]; metal-binding site 657324000266 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 657324000267 putative deacylase active site [active] 657324000268 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 657324000269 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 657324000270 putative active site [active] 657324000271 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 657324000272 Archaeal ATPase; Region: Arch_ATPase; pfam01637 657324000273 AAA domain; Region: AAA_14; pfam13173 657324000274 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657324000275 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 657324000276 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 657324000277 HSP70 interaction site [polypeptide binding]; other site 657324000278 EDD domain protein, DegV family; Region: DegV; TIGR00762 657324000279 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 657324000280 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 657324000281 DNA-binding site [nucleotide binding]; DNA binding site 657324000282 RNA-binding motif; other site 657324000283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 657324000284 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 657324000285 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 657324000286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324000287 Walker A motif; other site 657324000288 ATP binding site [chemical binding]; other site 657324000289 Walker B motif; other site 657324000290 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 657324000291 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657324000292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657324000293 Major Facilitator Superfamily; Region: MFS_1; pfam07690 657324000294 putative substrate translocation pore; other site 657324000295 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 657324000296 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 657324000297 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 657324000298 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 657324000299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657324000300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324000301 homodimer interface [polypeptide binding]; other site 657324000302 catalytic residue [active] 657324000303 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657324000304 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 657324000305 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 657324000306 active site 657324000307 metal binding site [ion binding]; metal-binding site 657324000308 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 657324000309 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 657324000310 Pyruvate formate lyase 1; Region: PFL1; cd01678 657324000311 coenzyme A binding site [chemical binding]; other site 657324000312 active site 657324000313 catalytic residues [active] 657324000314 glycine loop; other site 657324000315 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 657324000316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324000317 FeS/SAM binding site; other site 657324000318 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 657324000319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324000320 dimer interface [polypeptide binding]; other site 657324000321 putative CheW interface [polypeptide binding]; other site 657324000322 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 657324000323 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 657324000324 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 657324000325 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 657324000326 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324000327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324000328 dimer interface [polypeptide binding]; other site 657324000329 conserved gate region; other site 657324000330 putative PBP binding loops; other site 657324000331 ABC-ATPase subunit interface; other site 657324000332 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 657324000333 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324000334 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657324000335 Response regulator receiver domain; Region: Response_reg; pfam00072 657324000336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324000337 active site 657324000338 phosphorylation site [posttranslational modification] 657324000339 intermolecular recognition site; other site 657324000340 dimerization interface [polypeptide binding]; other site 657324000341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657324000342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324000343 Histidine kinase; Region: His_kinase; pfam06580 657324000344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324000345 ATP binding site [chemical binding]; other site 657324000346 Mg2+ binding site [ion binding]; other site 657324000347 G-X-G motif; other site 657324000348 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 657324000349 active site 657324000350 catalytic residues [active] 657324000351 beta-phosphoglucomutase; Region: bPGM; TIGR01990 657324000352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324000353 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 657324000354 active site 657324000355 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 657324000356 metal binding site [ion binding]; metal-binding site 657324000357 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 657324000358 putative metal binding site [ion binding]; other site 657324000359 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 657324000360 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 657324000361 putative sugar binding sites [chemical binding]; other site 657324000362 Q-X-W motif; other site 657324000363 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 657324000364 putative metal binding site [ion binding]; other site 657324000365 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 657324000366 putative metal binding site [ion binding]; other site 657324000367 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 657324000368 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 657324000369 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657324000370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657324000371 catalytic residue [active] 657324000372 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 657324000373 substrate binding site; other site 657324000374 dimer interface; other site 657324000375 UGMP family protein; Validated; Region: PRK09604 657324000376 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 657324000377 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 657324000378 ribonuclease Z; Reviewed; Region: PRK00055 657324000379 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 657324000380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324000381 Coenzyme A binding pocket [chemical binding]; other site 657324000382 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 657324000383 Glycoprotease family; Region: Peptidase_M22; pfam00814 657324000384 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 657324000385 YcxB-like protein; Region: YcxB; pfam14317 657324000386 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 657324000387 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 657324000388 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 657324000389 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 657324000390 RNA binding site [nucleotide binding]; other site 657324000391 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 657324000392 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657324000393 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 657324000394 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 657324000395 5S rRNA interface [nucleotide binding]; other site 657324000396 CTC domain interface [polypeptide binding]; other site 657324000397 L16 interface [polypeptide binding]; other site 657324000398 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 657324000399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 657324000400 Predicted dehydrogenase [General function prediction only]; Region: COG0579 657324000401 hydroxyglutarate oxidase; Provisional; Region: PRK11728 657324000402 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 657324000403 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 657324000404 amphipathic channel; other site 657324000405 Asn-Pro-Ala signature motifs; other site 657324000406 glycerol kinase; Provisional; Region: glpK; PRK00047 657324000407 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 657324000408 N- and C-terminal domain interface [polypeptide binding]; other site 657324000409 active site 657324000410 MgATP binding site [chemical binding]; other site 657324000411 catalytic site [active] 657324000412 metal binding site [ion binding]; metal-binding site 657324000413 glycerol binding site [chemical binding]; other site 657324000414 homotetramer interface [polypeptide binding]; other site 657324000415 homodimer interface [polypeptide binding]; other site 657324000416 FBP binding site [chemical binding]; other site 657324000417 protein IIAGlc interface [polypeptide binding]; other site 657324000418 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 657324000419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324000420 motif II; other site 657324000421 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657324000422 homoserine dehydrogenase; Provisional; Region: PRK06349 657324000423 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 657324000424 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 657324000425 hypothetical protein; Provisional; Region: PRK04435 657324000426 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 657324000427 DNA-binding interface [nucleotide binding]; DNA binding site 657324000428 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 657324000429 peptide chain release factor 2; Provisional; Region: PRK05589 657324000430 PCRF domain; Region: PCRF; pfam03462 657324000431 RF-1 domain; Region: RF-1; pfam00472 657324000432 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 657324000433 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 657324000434 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 657324000435 protein binding site [polypeptide binding]; other site 657324000436 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 657324000437 Catalytic dyad [active] 657324000438 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 657324000439 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 657324000440 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 657324000441 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657324000442 Bacterial SH3 domain; Region: SH3_3; cl17532 657324000443 Bacterial SH3 domain; Region: SH3_3; pfam08239 657324000444 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 657324000445 NlpC/P60 family; Region: NLPC_P60; pfam00877 657324000446 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 657324000447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657324000448 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657324000449 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 657324000450 homotrimer interaction site [polypeptide binding]; other site 657324000451 putative active site [active] 657324000452 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 657324000453 S1 domain; Region: S1_2; pfam13509 657324000454 S1 domain; Region: S1_2; pfam13509 657324000455 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 657324000456 RNA binding site [nucleotide binding]; other site 657324000457 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 657324000458 active site 657324000459 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 657324000460 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 657324000461 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 657324000462 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 657324000463 Transglycosylase; Region: Transgly; pfam00912 657324000464 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 657324000465 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 657324000466 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 657324000467 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 657324000468 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 657324000469 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 657324000470 intersubunit interface [polypeptide binding]; other site 657324000471 active site 657324000472 zinc binding site [ion binding]; other site 657324000473 Na+ binding site [ion binding]; other site 657324000474 putative lipid kinase; Reviewed; Region: PRK13337 657324000475 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 657324000476 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 657324000477 dimerization domain swap beta strand [polypeptide binding]; other site 657324000478 regulatory protein interface [polypeptide binding]; other site 657324000479 active site 657324000480 regulatory phosphorylation site [posttranslational modification]; other site 657324000481 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 657324000482 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 657324000483 FAD binding domain; Region: FAD_binding_4; pfam01565 657324000484 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 657324000485 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 657324000486 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 657324000487 oligomer interface [polypeptide binding]; other site 657324000488 putative active site [active] 657324000489 metal binding site [ion binding]; metal-binding site 657324000490 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 657324000491 Hpr binding site; other site 657324000492 active site 657324000493 homohexamer subunit interaction site [polypeptide binding]; other site 657324000494 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 657324000495 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 657324000496 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 657324000497 metal binding site [ion binding]; metal-binding site 657324000498 UvrB/uvrC motif; Region: UVR; pfam02151 657324000499 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 657324000500 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657324000501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324000502 Walker A/P-loop; other site 657324000503 ATP binding site [chemical binding]; other site 657324000504 Q-loop/lid; other site 657324000505 ABC transporter signature motif; other site 657324000506 Walker B; other site 657324000507 D-loop; other site 657324000508 H-loop/switch region; other site 657324000509 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324000510 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 657324000511 TM-ABC transporter signature motif; other site 657324000512 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 657324000513 zinc binding site [ion binding]; other site 657324000514 putative ligand binding site [chemical binding]; other site 657324000515 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657324000516 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657324000517 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657324000518 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657324000519 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 657324000520 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 657324000521 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 657324000522 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657324000523 RNA binding surface [nucleotide binding]; other site 657324000524 30S ribosomal protein S11; Validated; Region: PRK05309 657324000525 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 657324000526 30S ribosomal protein S13; Region: bact_S13; TIGR03631 657324000527 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 657324000528 rRNA binding site [nucleotide binding]; other site 657324000529 predicted 30S ribosome binding site; other site 657324000530 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 657324000531 RNA binding site [nucleotide binding]; other site 657324000532 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 657324000533 active site 657324000534 adenylate kinase; Reviewed; Region: adk; PRK00279 657324000535 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 657324000536 AMP-binding site [chemical binding]; other site 657324000537 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 657324000538 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 657324000539 SecY translocase; Region: SecY; pfam00344 657324000540 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 657324000541 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 657324000542 23S rRNA binding site [nucleotide binding]; other site 657324000543 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 657324000544 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 657324000545 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 657324000546 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 657324000547 23S rRNA interface [nucleotide binding]; other site 657324000548 L21e interface [polypeptide binding]; other site 657324000549 5S rRNA interface [nucleotide binding]; other site 657324000550 L27 interface [polypeptide binding]; other site 657324000551 L5 interface [polypeptide binding]; other site 657324000552 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 657324000553 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 657324000554 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 657324000555 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 657324000556 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 657324000557 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 657324000558 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 657324000559 RNA binding site [nucleotide binding]; other site 657324000560 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 657324000561 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 657324000562 putative translocon interaction site; other site 657324000563 23S rRNA interface [nucleotide binding]; other site 657324000564 signal recognition particle (SRP54) interaction site; other site 657324000565 L23 interface [polypeptide binding]; other site 657324000566 trigger factor interaction site; other site 657324000567 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 657324000568 23S rRNA interface [nucleotide binding]; other site 657324000569 5S rRNA interface [nucleotide binding]; other site 657324000570 putative antibiotic binding site [chemical binding]; other site 657324000571 L25 interface [polypeptide binding]; other site 657324000572 L27 interface [polypeptide binding]; other site 657324000573 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 657324000574 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 657324000575 G-X-X-G motif; other site 657324000576 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 657324000577 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 657324000578 protein-rRNA interface [nucleotide binding]; other site 657324000579 putative translocon binding site; other site 657324000580 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 657324000581 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 657324000582 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 657324000583 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 657324000584 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 657324000585 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 657324000586 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 657324000587 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 657324000588 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 657324000589 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 657324000590 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657324000591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 657324000592 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324000593 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324000594 metal binding site [ion binding]; metal-binding site 657324000595 active site 657324000596 I-site; other site 657324000597 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 657324000598 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324000599 TM-ABC transporter signature motif; other site 657324000600 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 657324000601 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 657324000602 Walker A/P-loop; other site 657324000603 ATP binding site [chemical binding]; other site 657324000604 Q-loop/lid; other site 657324000605 ABC transporter signature motif; other site 657324000606 Walker B; other site 657324000607 D-loop; other site 657324000608 H-loop/switch region; other site 657324000609 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 657324000610 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324000611 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657324000612 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657324000613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657324000614 DNA-binding site [nucleotide binding]; DNA binding site 657324000615 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324000616 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324000617 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 657324000618 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324000619 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 657324000620 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 657324000621 dimerization interface [polypeptide binding]; other site 657324000622 Histidine kinase; Region: His_kinase; pfam06580 657324000623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324000624 ATP binding site [chemical binding]; other site 657324000625 Mg2+ binding site [ion binding]; other site 657324000626 G-X-G motif; other site 657324000627 Response regulator receiver domain; Region: Response_reg; pfam00072 657324000628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324000629 active site 657324000630 phosphorylation site [posttranslational modification] 657324000631 intermolecular recognition site; other site 657324000632 dimerization interface [polypeptide binding]; other site 657324000633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657324000634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324000635 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657324000636 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 657324000637 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 657324000638 transmembrane helices; other site 657324000639 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 657324000640 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 657324000641 FAD binding site [chemical binding]; other site 657324000642 serine O-acetyltransferase; Region: cysE; TIGR01172 657324000643 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 657324000644 trimer interface [polypeptide binding]; other site 657324000645 active site 657324000646 substrate binding site [chemical binding]; other site 657324000647 CoA binding site [chemical binding]; other site 657324000648 RelB antitoxin; Region: RelB; cl01171 657324000649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 657324000650 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 657324000651 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 657324000652 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 657324000653 Fic family protein [Function unknown]; Region: COG3177 657324000654 Fic/DOC family; Region: Fic; pfam02661 657324000655 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 657324000656 putative active site pocket [active] 657324000657 cleavage site 657324000658 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 657324000659 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657324000660 Protein of unknown function (DUF418); Region: DUF418; cl12135 657324000661 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 657324000662 metabolite-proton symporter; Region: 2A0106; TIGR00883 657324000663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657324000664 active site 657324000665 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 657324000666 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657324000667 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 657324000668 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 657324000669 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 657324000670 dihydrodipicolinate synthase; Region: dapA; TIGR00674 657324000671 dimer interface [polypeptide binding]; other site 657324000672 active site 657324000673 catalytic residue [active] 657324000674 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 657324000675 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 657324000676 CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913 657324000677 tetramer interface [polypeptide binding]; other site 657324000678 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 657324000679 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 657324000680 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324000681 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 657324000682 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 657324000683 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324000684 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324000685 metal binding site [ion binding]; metal-binding site 657324000686 active site 657324000687 I-site; other site 657324000688 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 657324000689 active site 657324000690 metal binding site [ion binding]; metal-binding site 657324000691 Ion transport protein; Region: Ion_trans; pfam00520 657324000692 Ion channel; Region: Ion_trans_2; pfam07885 657324000693 TrkA-C domain; Region: TrkA_C; pfam02080 657324000694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324000695 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657324000696 active site 657324000697 motif I; other site 657324000698 motif II; other site 657324000699 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657324000700 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 657324000701 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 657324000702 nucleophilic elbow; other site 657324000703 catalytic triad; other site 657324000704 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 657324000705 TRAM domain; Region: TRAM; cl01282 657324000706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324000707 S-adenosylmethionine binding site [chemical binding]; other site 657324000708 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 657324000709 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 657324000710 generic binding surface I; other site 657324000711 generic binding surface II; other site 657324000712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324000713 Zn2+ binding site [ion binding]; other site 657324000714 Mg2+ binding site [ion binding]; other site 657324000715 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 657324000716 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 657324000717 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 657324000718 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 657324000719 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 657324000720 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 657324000721 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 657324000722 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 657324000723 Predicted transcriptional regulators [Transcription]; Region: COG1695 657324000724 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 657324000725 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 657324000726 MutS domain III; Region: MutS_III; pfam05192 657324000727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324000728 Walker A/P-loop; other site 657324000729 ATP binding site [chemical binding]; other site 657324000730 Q-loop/lid; other site 657324000731 ABC transporter signature motif; other site 657324000732 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 657324000733 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657324000734 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 657324000735 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 657324000736 Walker A/P-loop; other site 657324000737 ATP binding site [chemical binding]; other site 657324000738 Q-loop/lid; other site 657324000739 ABC transporter signature motif; other site 657324000740 Walker B; other site 657324000741 D-loop; other site 657324000742 H-loop/switch region; other site 657324000743 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 657324000744 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 657324000745 Walker A/P-loop; other site 657324000746 ATP binding site [chemical binding]; other site 657324000747 Q-loop/lid; other site 657324000748 ABC transporter signature motif; other site 657324000749 Walker B; other site 657324000750 D-loop; other site 657324000751 H-loop/switch region; other site 657324000752 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 657324000753 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 657324000754 TM-ABC transporter signature motif; other site 657324000755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324000756 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 657324000757 TM-ABC transporter signature motif; other site 657324000758 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 657324000759 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 657324000760 putative ligand binding site [chemical binding]; other site 657324000761 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 657324000762 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657324000763 RNA binding surface [nucleotide binding]; other site 657324000764 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 657324000765 active site 657324000766 uracil binding [chemical binding]; other site 657324000767 methionine aminopeptidase; Provisional; Region: PRK12318 657324000768 SEC-C motif; Region: SEC-C; pfam02810 657324000769 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 657324000770 active site 657324000771 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 657324000772 NlpC/P60 family; Region: NLPC_P60; cl17555 657324000773 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 657324000774 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 657324000775 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 657324000776 putative acyl-acceptor binding pocket; other site 657324000777 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 657324000778 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 657324000779 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657324000780 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657324000781 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 657324000782 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 657324000783 ATP-grasp domain; Region: ATP-grasp_4; cl17255 657324000784 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324000785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324000786 non-specific DNA binding site [nucleotide binding]; other site 657324000787 salt bridge; other site 657324000788 sequence-specific DNA binding site [nucleotide binding]; other site 657324000789 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 657324000790 30S subunit binding site; other site 657324000791 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 657324000792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657324000793 NAD(P) binding site [chemical binding]; other site 657324000794 active site 657324000795 Predicted transcriptional regulator [Transcription]; Region: COG2378 657324000796 WYL domain; Region: WYL; pfam13280 657324000797 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 657324000798 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657324000799 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 657324000800 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657324000801 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 657324000802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324000803 Walker A/P-loop; other site 657324000804 ATP binding site [chemical binding]; other site 657324000805 Q-loop/lid; other site 657324000806 ABC transporter signature motif; other site 657324000807 Walker B; other site 657324000808 D-loop; other site 657324000809 H-loop/switch region; other site 657324000810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324000811 Radical SAM superfamily; Region: Radical_SAM; pfam04055 657324000812 FeS/SAM binding site; other site 657324000813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324000814 ABC transporter signature motif; other site 657324000815 Walker B; other site 657324000816 D-loop; other site 657324000817 AAA domain; Region: AAA_23; pfam13476 657324000818 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 657324000819 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657324000820 active site 657324000821 metal binding site [ion binding]; metal-binding site 657324000822 DNA binding site [nucleotide binding] 657324000823 Cache domain; Region: Cache_1; pfam02743 657324000824 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324000825 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324000826 dimer interface [polypeptide binding]; other site 657324000827 putative CheW interface [polypeptide binding]; other site 657324000828 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 657324000829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 657324000830 phosphorylation site [posttranslational modification] 657324000831 Response regulator receiver domain; Region: Response_reg; pfam00072 657324000832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324000833 active site 657324000834 phosphorylation site [posttranslational modification] 657324000835 intermolecular recognition site; other site 657324000836 dimerization interface [polypeptide binding]; other site 657324000837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657324000838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657324000839 dimer interface [polypeptide binding]; other site 657324000840 phosphorylation site [posttranslational modification] 657324000841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324000842 ATP binding site [chemical binding]; other site 657324000843 Mg2+ binding site [ion binding]; other site 657324000844 G-X-G motif; other site 657324000845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324000846 Response regulator receiver domain; Region: Response_reg; pfam00072 657324000847 active site 657324000848 phosphorylation site [posttranslational modification] 657324000849 intermolecular recognition site; other site 657324000850 dimerization interface [polypeptide binding]; other site 657324000851 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 657324000852 ligand binding site [chemical binding]; other site 657324000853 active site 657324000854 UGI interface [polypeptide binding]; other site 657324000855 catalytic site [active] 657324000856 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 657324000857 HTH domain; Region: HTH_11; pfam08279 657324000858 3H domain; Region: 3H; pfam02829 657324000859 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 657324000860 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 657324000861 dimerization interface [polypeptide binding]; other site 657324000862 active site 657324000863 L-aspartate oxidase; Provisional; Region: PRK06175 657324000864 FAD binding domain; Region: FAD_binding_2; pfam00890 657324000865 Quinolinate synthetase A protein; Region: NadA; pfam02445 657324000866 TSCPD domain; Region: TSCPD; cl14834 657324000867 YARHG domain; Region: YARHG; pfam13308 657324000868 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 657324000869 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 657324000870 active site 657324000871 homodimer interface [polypeptide binding]; other site 657324000872 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 657324000873 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 657324000874 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 657324000875 NAD synthetase; Provisional; Region: PRK13980 657324000876 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 657324000877 Ligand Binding Site [chemical binding]; other site 657324000878 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 657324000879 Repair protein; Region: Repair_PSII; pfam04536 657324000880 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 657324000881 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 657324000882 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657324000883 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657324000884 Walker A/P-loop; other site 657324000885 ATP binding site [chemical binding]; other site 657324000886 Q-loop/lid; other site 657324000887 ABC transporter signature motif; other site 657324000888 Walker B; other site 657324000889 D-loop; other site 657324000890 H-loop/switch region; other site 657324000891 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 657324000892 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 657324000893 Bacterial PH domain; Region: DUF304; pfam03703 657324000894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324000895 non-specific DNA binding site [nucleotide binding]; other site 657324000896 salt bridge; other site 657324000897 sequence-specific DNA binding site [nucleotide binding]; other site 657324000898 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 657324000899 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 657324000900 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 657324000901 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 657324000902 Protein of unknown function DUF58; Region: DUF58; pfam01882 657324000903 MoxR-like ATPases [General function prediction only]; Region: COG0714 657324000904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324000905 Walker A motif; other site 657324000906 ATP binding site [chemical binding]; other site 657324000907 Walker B motif; other site 657324000908 arginine finger; other site 657324000909 Condensation domain; Region: Condensation; pfam00668 657324000910 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 657324000911 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 657324000912 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 657324000913 acyl-activating enzyme (AAE) consensus motif; other site 657324000914 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 657324000915 AMP binding site [chemical binding]; other site 657324000916 CoA binding site [chemical binding]; other site 657324000917 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 657324000918 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 657324000919 active site 657324000920 substrate binding site [chemical binding]; other site 657324000921 metal binding site [ion binding]; metal-binding site 657324000922 putative phosphoketolase; Provisional; Region: PRK05261 657324000923 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 657324000924 TPP-binding site; other site 657324000925 XFP C-terminal domain; Region: XFP_C; pfam09363 657324000926 XFP N-terminal domain; Region: XFP_N; pfam09364 657324000927 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 657324000928 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 657324000929 S-ribosylhomocysteinase; Provisional; Region: PRK02260 657324000930 H+ Antiporter protein; Region: 2A0121; TIGR00900 657324000931 H+ Antiporter protein; Region: 2A0121; TIGR00900 657324000932 DJ-1 family protein; Region: not_thiJ; TIGR01383 657324000933 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 657324000934 conserved cys residue [active] 657324000935 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 657324000936 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 657324000937 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 657324000938 DNA binding residues [nucleotide binding] 657324000939 dimer interface [polypeptide binding]; other site 657324000940 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 657324000941 Carboxylesterase family; Region: COesterase; pfam00135 657324000942 substrate binding pocket [chemical binding]; other site 657324000943 catalytic triad [active] 657324000944 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 657324000945 Carbon starvation protein CstA; Region: CstA; pfam02554 657324000946 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 657324000947 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 657324000948 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324000949 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324000950 dimer interface [polypeptide binding]; other site 657324000951 putative CheW interface [polypeptide binding]; other site 657324000952 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 657324000953 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 657324000954 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657324000955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324000956 Walker A/P-loop; other site 657324000957 ATP binding site [chemical binding]; other site 657324000958 Q-loop/lid; other site 657324000959 ABC transporter signature motif; other site 657324000960 Walker B; other site 657324000961 D-loop; other site 657324000962 H-loop/switch region; other site 657324000963 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 657324000964 active site 657324000965 catalytic triad [active] 657324000966 oxyanion hole [active] 657324000967 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 657324000968 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 657324000969 active site 657324000970 dimer interface [polypeptide binding]; other site 657324000971 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 657324000972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324000973 active site 657324000974 phosphorylation site [posttranslational modification] 657324000975 intermolecular recognition site; other site 657324000976 dimerization interface [polypeptide binding]; other site 657324000977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 657324000978 DNA binding residues [nucleotide binding] 657324000979 dimerization interface [polypeptide binding]; other site 657324000980 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 657324000981 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 657324000982 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 657324000983 ABC-2 type transporter; Region: ABC2_membrane; cl17235 657324000984 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657324000985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324000986 Walker A/P-loop; other site 657324000987 ATP binding site [chemical binding]; other site 657324000988 Q-loop/lid; other site 657324000989 ABC transporter signature motif; other site 657324000990 Walker B; other site 657324000991 D-loop; other site 657324000992 H-loop/switch region; other site 657324000993 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 657324000994 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657324000995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657324000996 ABC transporter; Region: ABC_tran_2; pfam12848 657324000997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657324000998 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 657324000999 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 657324001000 active site 657324001001 nucleophile elbow; other site 657324001002 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657324001003 LytTr DNA-binding domain; Region: LytTR; smart00850 657324001004 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 657324001005 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 657324001006 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 657324001007 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 657324001008 putative deacylase active site [active] 657324001009 Predicted membrane protein [Function unknown]; Region: COG2364 657324001010 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 657324001011 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 657324001012 active site 657324001013 metal binding site [ion binding]; metal-binding site 657324001014 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657324001015 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 657324001016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657324001017 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 657324001018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657324001019 NAD(P) binding site [chemical binding]; other site 657324001020 AAA domain; Region: AAA_17; pfam13207 657324001021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324001022 ATP binding site [chemical binding]; other site 657324001023 Mg2+ binding site [ion binding]; other site 657324001024 G-X-G motif; other site 657324001025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324001026 Response regulator receiver domain; Region: Response_reg; pfam00072 657324001027 active site 657324001028 phosphorylation site [posttranslational modification] 657324001029 intermolecular recognition site; other site 657324001030 dimerization interface [polypeptide binding]; other site 657324001031 Abi-like protein; Region: Abi_2; pfam07751 657324001032 elongation factor Tu; Reviewed; Region: PRK00049 657324001033 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 657324001034 G1 box; other site 657324001035 GEF interaction site [polypeptide binding]; other site 657324001036 GTP/Mg2+ binding site [chemical binding]; other site 657324001037 Switch I region; other site 657324001038 G2 box; other site 657324001039 G3 box; other site 657324001040 Switch II region; other site 657324001041 G4 box; other site 657324001042 G5 box; other site 657324001043 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 657324001044 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 657324001045 Antibiotic Binding Site [chemical binding]; other site 657324001046 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 657324001047 S17 interaction site [polypeptide binding]; other site 657324001048 S8 interaction site; other site 657324001049 16S rRNA interaction site [nucleotide binding]; other site 657324001050 streptomycin interaction site [chemical binding]; other site 657324001051 23S rRNA interaction site [nucleotide binding]; other site 657324001052 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 657324001053 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 657324001054 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 657324001055 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 657324001056 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 657324001057 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 657324001058 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 657324001059 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 657324001060 G-loop; other site 657324001061 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 657324001062 DNA binding site [nucleotide binding] 657324001063 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 657324001064 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 657324001065 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 657324001066 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 657324001067 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 657324001068 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 657324001069 RPB1 interaction site [polypeptide binding]; other site 657324001070 RPB10 interaction site [polypeptide binding]; other site 657324001071 RPB11 interaction site [polypeptide binding]; other site 657324001072 RPB3 interaction site [polypeptide binding]; other site 657324001073 RPB12 interaction site [polypeptide binding]; other site 657324001074 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 657324001075 core dimer interface [polypeptide binding]; other site 657324001076 peripheral dimer interface [polypeptide binding]; other site 657324001077 L10 interface [polypeptide binding]; other site 657324001078 L11 interface [polypeptide binding]; other site 657324001079 putative EF-Tu interaction site [polypeptide binding]; other site 657324001080 putative EF-G interaction site [polypeptide binding]; other site 657324001081 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 657324001082 mRNA/rRNA interface [nucleotide binding]; other site 657324001083 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 657324001084 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 657324001085 23S rRNA interface [nucleotide binding]; other site 657324001086 L7/L12 interface [polypeptide binding]; other site 657324001087 putative thiostrepton binding site; other site 657324001088 L25 interface [polypeptide binding]; other site 657324001089 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 657324001090 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 657324001091 putative homodimer interface [polypeptide binding]; other site 657324001092 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 657324001093 heterodimer interface [polypeptide binding]; other site 657324001094 homodimer interface [polypeptide binding]; other site 657324001095 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324001096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324001097 dimer interface [polypeptide binding]; other site 657324001098 conserved gate region; other site 657324001099 putative PBP binding loops; other site 657324001100 ABC-ATPase subunit interface; other site 657324001101 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 657324001102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324001103 dimer interface [polypeptide binding]; other site 657324001104 conserved gate region; other site 657324001105 putative PBP binding loops; other site 657324001106 ABC-ATPase subunit interface; other site 657324001107 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324001108 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324001109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324001110 DNA binding site [nucleotide binding] 657324001111 domain linker motif; other site 657324001112 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657324001113 dimerization interface [polypeptide binding]; other site 657324001114 ligand binding site [chemical binding]; other site 657324001115 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 657324001116 catalytic domain interface [polypeptide binding]; other site 657324001117 homodimer interface [polypeptide binding]; other site 657324001118 putative active site [active] 657324001119 Protein of unknown function, DUF608; Region: DUF608; pfam04685 657324001120 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657324001121 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657324001122 active site 657324001123 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 657324001124 HSP70 interaction site [polypeptide binding]; other site 657324001125 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 657324001126 homodimer interface [polypeptide binding]; other site 657324001127 maltodextrin glucosidase; Provisional; Region: PRK10785 657324001128 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 657324001129 active site 657324001130 homodimer interface [polypeptide binding]; other site 657324001131 catalytic site [active] 657324001132 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 657324001133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324001134 Walker A motif; other site 657324001135 ATP binding site [chemical binding]; other site 657324001136 Walker B motif; other site 657324001137 arginine finger; other site 657324001138 Peptidase family M41; Region: Peptidase_M41; pfam01434 657324001139 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657324001140 active site 657324001141 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 657324001142 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 657324001143 TilS substrate C-terminal domain; Region: TilS_C; smart00977 657324001144 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657324001145 RNA binding surface [nucleotide binding]; other site 657324001146 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 657324001147 IHF dimer interface [polypeptide binding]; other site 657324001148 IHF - DNA interface [nucleotide binding]; other site 657324001149 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 657324001150 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 657324001151 active site 657324001152 NTP binding site [chemical binding]; other site 657324001153 metal binding triad [ion binding]; metal-binding site 657324001154 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 657324001155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324001156 Zn2+ binding site [ion binding]; other site 657324001157 Mg2+ binding site [ion binding]; other site 657324001158 prolyl-tRNA synthetase; Provisional; Region: PRK08661 657324001159 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 657324001160 dimer interface [polypeptide binding]; other site 657324001161 motif 1; other site 657324001162 active site 657324001163 motif 2; other site 657324001164 motif 3; other site 657324001165 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 657324001166 anticodon binding site; other site 657324001167 zinc-binding site [ion binding]; other site 657324001168 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657324001169 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324001170 metal binding site [ion binding]; metal-binding site 657324001171 active site 657324001172 I-site; other site 657324001173 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657324001174 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657324001175 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657324001176 active site 657324001177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657324001178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324001179 active site 657324001180 phosphorylation site [posttranslational modification] 657324001181 intermolecular recognition site; other site 657324001182 dimerization interface [polypeptide binding]; other site 657324001183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657324001184 DNA binding site [nucleotide binding] 657324001185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657324001186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657324001187 dimerization interface [polypeptide binding]; other site 657324001188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657324001189 dimer interface [polypeptide binding]; other site 657324001190 phosphorylation site [posttranslational modification] 657324001191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324001192 ATP binding site [chemical binding]; other site 657324001193 Mg2+ binding site [ion binding]; other site 657324001194 G-X-G motif; other site 657324001195 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 657324001196 S-adenosylmethionine synthetase; Validated; Region: PRK05250 657324001197 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 657324001198 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 657324001199 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657324001200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324001201 Zn2+ binding site [ion binding]; other site 657324001202 Mg2+ binding site [ion binding]; other site 657324001203 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 657324001204 AAA domain; Region: AAA_30; pfam13604 657324001205 Family description; Region: UvrD_C_2; pfam13538 657324001206 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 657324001207 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657324001208 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 657324001209 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 657324001210 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657324001211 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 657324001212 rod shape-determining protein Mbl; Provisional; Region: PRK13928 657324001213 MreB and similar proteins; Region: MreB_like; cd10225 657324001214 nucleotide binding site [chemical binding]; other site 657324001215 Mg binding site [ion binding]; other site 657324001216 putative protofilament interaction site [polypeptide binding]; other site 657324001217 RodZ interaction site [polypeptide binding]; other site 657324001218 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 657324001219 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 657324001220 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 657324001221 excinuclease ABC subunit B; Provisional; Region: PRK05298 657324001222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657324001223 ATP binding site [chemical binding]; other site 657324001224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657324001225 nucleotide binding region [chemical binding]; other site 657324001226 ATP-binding site [chemical binding]; other site 657324001227 Ultra-violet resistance protein B; Region: UvrB; pfam12344 657324001228 UvrB/uvrC motif; Region: UVR; pfam02151 657324001229 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324001230 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324001231 dimer interface [polypeptide binding]; other site 657324001232 putative CheW interface [polypeptide binding]; other site 657324001233 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 657324001234 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 657324001235 AIR carboxylase; Region: AIRC; smart01001 657324001236 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 657324001237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324001238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324001239 dimer interface [polypeptide binding]; other site 657324001240 conserved gate region; other site 657324001241 ABC-ATPase subunit interface; other site 657324001242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324001243 dimer interface [polypeptide binding]; other site 657324001244 conserved gate region; other site 657324001245 putative PBP binding loops; other site 657324001246 ABC-ATPase subunit interface; other site 657324001247 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 657324001248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324001249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324001250 DNA binding site [nucleotide binding] 657324001251 domain linker motif; other site 657324001252 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657324001253 dimerization interface [polypeptide binding]; other site 657324001254 ligand binding site [chemical binding]; other site 657324001255 Cache domain; Region: Cache_1; pfam02743 657324001256 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 657324001257 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 657324001258 dimerization interface [polypeptide binding]; other site 657324001259 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 657324001260 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 657324001261 active site 657324001262 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 657324001263 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 657324001264 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 657324001265 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 657324001266 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 657324001267 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 657324001268 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 657324001269 dimerization domain swap beta strand [polypeptide binding]; other site 657324001270 regulatory protein interface [polypeptide binding]; other site 657324001271 active site 657324001272 regulatory phosphorylation site [posttranslational modification]; other site 657324001273 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 657324001274 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657324001275 active site 657324001276 phosphorylation site [posttranslational modification] 657324001277 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 657324001278 active site 657324001279 P-loop; other site 657324001280 phosphorylation site [posttranslational modification] 657324001281 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 657324001282 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 657324001283 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 657324001284 putative substrate binding site [chemical binding]; other site 657324001285 putative ATP binding site [chemical binding]; other site 657324001286 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 657324001287 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 657324001288 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 657324001289 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324001290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324001291 metal binding site [ion binding]; metal-binding site 657324001292 active site 657324001293 I-site; other site 657324001294 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324001295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324001296 sequence-specific DNA binding site [nucleotide binding]; other site 657324001297 salt bridge; other site 657324001298 PIN domain; Region: PIN_3; pfam13470 657324001299 RelB antitoxin; Region: RelB; cl01171 657324001300 HipA-like C-terminal domain; Region: HipA_C; pfam07804 657324001301 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 657324001302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 657324001303 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 657324001304 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 657324001305 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 657324001306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324001307 active site 657324001308 motif I; other site 657324001309 motif II; other site 657324001310 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 657324001311 dimer interface [polypeptide binding]; other site 657324001312 active site 657324001313 Methyltransferase domain; Region: Methyltransf_23; pfam13489 657324001314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324001315 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 657324001316 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 657324001317 putative active site [active] 657324001318 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 657324001319 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324001320 Radical SAM superfamily; Region: Radical_SAM; pfam04055 657324001321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324001322 FeS/SAM binding site; other site 657324001323 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 657324001324 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 657324001325 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 657324001326 HEPN domain; Region: HEPN; cl00824 657324001327 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 657324001328 active site 657324001329 NTP binding site [chemical binding]; other site 657324001330 metal binding triad [ion binding]; metal-binding site 657324001331 antibiotic binding site [chemical binding]; other site 657324001332 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 657324001333 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 657324001334 putative NAD(P) binding site [chemical binding]; other site 657324001335 catalytic Zn binding site [ion binding]; other site 657324001336 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 657324001337 substrate binding site; other site 657324001338 dimer interface; other site 657324001339 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 657324001340 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 657324001341 substrate binding site [chemical binding]; other site 657324001342 hexamer interface [polypeptide binding]; other site 657324001343 metal binding site [ion binding]; metal-binding site 657324001344 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 657324001345 Flavoprotein; Region: Flavoprotein; pfam02441 657324001346 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 657324001347 Predicted membrane protein [Function unknown]; Region: COG4684 657324001348 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 657324001349 Clostripain family; Region: Peptidase_C11; pfam03415 657324001350 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324001351 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324001352 dimer interface [polypeptide binding]; other site 657324001353 putative CheW interface [polypeptide binding]; other site 657324001354 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324001355 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 657324001356 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 657324001357 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 657324001358 hinge; other site 657324001359 active site 657324001360 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657324001361 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657324001362 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 657324001363 Walker A/P-loop; other site 657324001364 ATP binding site [chemical binding]; other site 657324001365 Q-loop/lid; other site 657324001366 ABC transporter signature motif; other site 657324001367 Walker B; other site 657324001368 D-loop; other site 657324001369 H-loop/switch region; other site 657324001370 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 657324001371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324001372 Walker A/P-loop; other site 657324001373 ATP binding site [chemical binding]; other site 657324001374 Q-loop/lid; other site 657324001375 ABC transporter signature motif; other site 657324001376 Walker B; other site 657324001377 D-loop; other site 657324001378 H-loop/switch region; other site 657324001379 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 657324001380 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 657324001381 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 657324001382 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 657324001383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657324001384 ATP binding site [chemical binding]; other site 657324001385 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 657324001386 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 657324001387 Sulfate transporter family; Region: Sulfate_transp; pfam00916 657324001388 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 657324001389 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 657324001390 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657324001391 Walker A motif; other site 657324001392 ATP binding site [chemical binding]; other site 657324001393 Walker B motif; other site 657324001394 Surfactant protein C, N terminal propeptide; Region: SP_C-Propep; pfam08999 657324001395 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 657324001396 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 657324001397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 657324001398 Bacterial transcriptional activator domain; Region: BTAD; smart01043 657324001399 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 657324001400 putative active site [active] 657324001401 catalytic residue [active] 657324001402 SpoVG; Region: SpoVG; cl00915 657324001403 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 657324001404 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 657324001405 ligand binding site; other site 657324001406 oligomer interface; other site 657324001407 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 657324001408 dimer interface [polypeptide binding]; other site 657324001409 N-terminal domain interface [polypeptide binding]; other site 657324001410 sulfate 1 binding site; other site 657324001411 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 657324001412 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 657324001413 ligand binding site; other site 657324001414 oligomer interface; other site 657324001415 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 657324001416 dimer interface [polypeptide binding]; other site 657324001417 N-terminal domain interface [polypeptide binding]; other site 657324001418 sulfate 1 binding site; other site 657324001419 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 657324001420 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 657324001421 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657324001422 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657324001423 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 657324001424 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 657324001425 DNA replication protein DnaC; Validated; Region: PRK06835 657324001426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324001427 Walker A motif; other site 657324001428 ATP binding site [chemical binding]; other site 657324001429 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 657324001430 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 657324001431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657324001432 active site 657324001433 Sulfatase; Region: Sulfatase; cl17466 657324001434 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 657324001435 YhhN-like protein; Region: YhhN; pfam07947 657324001436 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 657324001437 active site 657324001438 catalytic site [active] 657324001439 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 657324001440 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 657324001441 FIC domain binding interface [polypeptide binding]; other site 657324001442 Fic/DOC family; Region: Fic; cl00960 657324001443 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657324001444 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657324001445 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 657324001446 Walker A/P-loop; other site 657324001447 ATP binding site [chemical binding]; other site 657324001448 Q-loop/lid; other site 657324001449 ABC transporter signature motif; other site 657324001450 Walker B; other site 657324001451 D-loop; other site 657324001452 H-loop/switch region; other site 657324001453 MarR family; Region: MarR_2; pfam12802 657324001454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 657324001455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657324001456 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 657324001457 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657324001458 nucleotide binding site [chemical binding]; other site 657324001459 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 657324001460 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 657324001461 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 657324001462 active site 657324001463 catalytic residues [active] 657324001464 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 657324001465 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 657324001466 PYR/PP interface [polypeptide binding]; other site 657324001467 dimer interface [polypeptide binding]; other site 657324001468 TPP binding site [chemical binding]; other site 657324001469 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 657324001470 transketolase; Reviewed; Region: PRK05899 657324001471 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 657324001472 TPP-binding site [chemical binding]; other site 657324001473 dimer interface [polypeptide binding]; other site 657324001474 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 657324001475 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 657324001476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324001477 FeS/SAM binding site; other site 657324001478 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 657324001479 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657324001480 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 657324001481 nudix motif; other site 657324001482 H+ Antiporter protein; Region: 2A0121; TIGR00900 657324001483 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657324001484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324001485 active site 657324001486 phosphorylation site [posttranslational modification] 657324001487 intermolecular recognition site; other site 657324001488 dimerization interface [polypeptide binding]; other site 657324001489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657324001490 DNA binding site [nucleotide binding] 657324001491 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 657324001492 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 657324001493 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 657324001494 active site 657324001495 catalytic residues [active] 657324001496 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 657324001497 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 657324001498 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 657324001499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 657324001500 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 657324001501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324001502 putative PBP binding loops; other site 657324001503 dimer interface [polypeptide binding]; other site 657324001504 ABC-ATPase subunit interface; other site 657324001505 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 657324001506 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 657324001507 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657324001508 Walker A/P-loop; other site 657324001509 ATP binding site [chemical binding]; other site 657324001510 Q-loop/lid; other site 657324001511 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 657324001512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324001513 ABC transporter signature motif; other site 657324001514 Walker B; other site 657324001515 D-loop; other site 657324001516 H-loop/switch region; other site 657324001517 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 657324001518 Methyltransferase domain; Region: Methyltransf_31; pfam13847 657324001519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324001520 S-adenosylmethionine binding site [chemical binding]; other site 657324001521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324001522 S-adenosylmethionine binding site [chemical binding]; other site 657324001523 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657324001524 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324001525 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324001526 DNA binding site [nucleotide binding] 657324001527 domain linker motif; other site 657324001528 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657324001529 dimerization interface [polypeptide binding]; other site 657324001530 ligand binding site [chemical binding]; other site 657324001531 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657324001532 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 657324001533 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657324001534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324001535 dimer interface [polypeptide binding]; other site 657324001536 conserved gate region; other site 657324001537 putative PBP binding loops; other site 657324001538 ABC-ATPase subunit interface; other site 657324001539 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324001540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324001541 dimer interface [polypeptide binding]; other site 657324001542 conserved gate region; other site 657324001543 putative PBP binding loops; other site 657324001544 ABC-ATPase subunit interface; other site 657324001545 4-alpha-glucanotransferase; Provisional; Region: PRK14508 657324001546 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 657324001547 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 657324001548 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 657324001549 N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749 657324001550 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 657324001551 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324001552 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657324001553 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324001554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324001555 dimer interface [polypeptide binding]; other site 657324001556 conserved gate region; other site 657324001557 putative PBP binding loops; other site 657324001558 ABC-ATPase subunit interface; other site 657324001559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324001560 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657324001561 dimerization interface [polypeptide binding]; other site 657324001562 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 657324001563 Histidine kinase; Region: His_kinase; pfam06580 657324001564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324001565 ATP binding site [chemical binding]; other site 657324001566 Mg2+ binding site [ion binding]; other site 657324001567 G-X-G motif; other site 657324001568 Response regulator receiver domain; Region: Response_reg; pfam00072 657324001569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324001570 active site 657324001571 phosphorylation site [posttranslational modification] 657324001572 intermolecular recognition site; other site 657324001573 dimerization interface [polypeptide binding]; other site 657324001574 trigger factor; Region: tig; TIGR00115 657324001575 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 657324001576 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 657324001577 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 657324001578 protein-export membrane protein SecD; Region: secD; TIGR01129 657324001579 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 657324001580 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 657324001581 Protein export membrane protein; Region: SecD_SecF; pfam02355 657324001582 seryl-tRNA synthetase; Provisional; Region: PRK05431 657324001583 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 657324001584 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 657324001585 motif 1; other site 657324001586 dimer interface [polypeptide binding]; other site 657324001587 active site 657324001588 motif 2; other site 657324001589 motif 3; other site 657324001590 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 657324001591 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 657324001592 G1 box; other site 657324001593 putative GEF interaction site [polypeptide binding]; other site 657324001594 GTP/Mg2+ binding site [chemical binding]; other site 657324001595 Switch I region; other site 657324001596 G2 box; other site 657324001597 G3 box; other site 657324001598 Switch II region; other site 657324001599 G4 box; other site 657324001600 G5 box; other site 657324001601 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 657324001602 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 657324001603 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657324001604 Walker A motif; other site 657324001605 ATP binding site [chemical binding]; other site 657324001606 Walker B motif; other site 657324001607 dihydrodipicolinate reductase; Provisional; Region: PRK00048 657324001608 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 657324001609 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 657324001610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 657324001611 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657324001612 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 657324001613 active site 657324001614 catalytic site [active] 657324001615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657324001616 dimerization interface [polypeptide binding]; other site 657324001617 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324001618 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324001619 dimer interface [polypeptide binding]; other site 657324001620 putative CheW interface [polypeptide binding]; other site 657324001621 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324001622 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657324001623 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 657324001624 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 657324001625 putative active site; other site 657324001626 signature motif; other site 657324001627 putative triphosphate binding site [ion binding]; other site 657324001628 elongation factor P; Validated; Region: PRK00529 657324001629 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 657324001630 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 657324001631 RNA binding site [nucleotide binding]; other site 657324001632 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 657324001633 RNA binding site [nucleotide binding]; other site 657324001634 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 657324001635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 657324001636 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 657324001637 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 657324001638 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 657324001639 Melibiase; Region: Melibiase; pfam02065 657324001640 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324001641 Zn2+ binding site [ion binding]; other site 657324001642 Mg2+ binding site [ion binding]; other site 657324001643 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 657324001644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 657324001645 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324001646 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324001647 dimer interface [polypeptide binding]; other site 657324001648 putative CheW interface [polypeptide binding]; other site 657324001649 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 657324001650 acyl carrier protein; Provisional; Region: acpP; PRK00982 657324001651 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 657324001652 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 657324001653 carboxyltransferase (CT) interaction site; other site 657324001654 biotinylation site [posttranslational modification]; other site 657324001655 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 657324001656 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 657324001657 ATP-grasp domain; Region: ATP-grasp_4; cl17255 657324001658 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 657324001659 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 657324001660 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 657324001661 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 657324001662 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 657324001663 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 657324001664 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 657324001665 FMN binding site [chemical binding]; other site 657324001666 substrate binding site [chemical binding]; other site 657324001667 putative catalytic residue [active] 657324001668 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 657324001669 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 657324001670 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 657324001671 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 657324001672 NAD(P) binding site [chemical binding]; other site 657324001673 homotetramer interface [polypeptide binding]; other site 657324001674 homodimer interface [polypeptide binding]; other site 657324001675 active site 657324001676 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 657324001677 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 657324001678 dimer interface [polypeptide binding]; other site 657324001679 active site 657324001680 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 657324001681 Transcriptional regulators [Transcription]; Region: MarR; COG1846 657324001682 MarR family; Region: MarR; pfam01047 657324001683 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 657324001684 DHH family; Region: DHH; pfam01368 657324001685 Predicted membrane protein [Function unknown]; Region: COG3601 657324001686 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 657324001687 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324001688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324001689 non-specific DNA binding site [nucleotide binding]; other site 657324001690 salt bridge; other site 657324001691 sequence-specific DNA binding site [nucleotide binding]; other site 657324001692 HflC protein; Region: hflC; TIGR01932 657324001693 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 657324001694 oligoendopeptidase F; Region: pepF; TIGR00181 657324001695 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 657324001696 active site 657324001697 Zn binding site [ion binding]; other site 657324001698 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 657324001699 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 657324001700 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 657324001701 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 657324001702 putative dimer interface [polypeptide binding]; other site 657324001703 putative anticodon binding site; other site 657324001704 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 657324001705 homodimer interface [polypeptide binding]; other site 657324001706 motif 1; other site 657324001707 motif 2; other site 657324001708 active site 657324001709 motif 3; other site 657324001710 Trp repressor protein; Region: Trp_repressor; cl17266 657324001711 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 657324001712 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 657324001713 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 657324001714 Part of AAA domain; Region: AAA_19; pfam13245 657324001715 Family description; Region: UvrD_C_2; pfam13538 657324001716 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 657324001717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324001718 S-adenosylmethionine binding site [chemical binding]; other site 657324001719 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region; Region: Gly_acyl_tr_C; pfam08444 657324001720 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657324001721 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 657324001722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324001723 Coenzyme A binding pocket [chemical binding]; other site 657324001724 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324001725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324001726 non-specific DNA binding site [nucleotide binding]; other site 657324001727 salt bridge; other site 657324001728 sequence-specific DNA binding site [nucleotide binding]; other site 657324001729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657324001730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324001731 Coenzyme A binding pocket [chemical binding]; other site 657324001732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324001733 S-adenosylmethionine binding site [chemical binding]; other site 657324001734 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657324001735 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657324001736 ABC transporter; Region: ABC_tran_2; pfam12848 657324001737 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 657324001738 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657324001739 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657324001740 LytTr DNA-binding domain; Region: LytTR; pfam04397 657324001741 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657324001742 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657324001743 Walker A/P-loop; other site 657324001744 ATP binding site [chemical binding]; other site 657324001745 Q-loop/lid; other site 657324001746 ABC transporter signature motif; other site 657324001747 Walker B; other site 657324001748 D-loop; other site 657324001749 H-loop/switch region; other site 657324001750 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 657324001751 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 657324001752 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 657324001753 active site 657324001754 oxyanion hole [active] 657324001755 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657324001756 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657324001757 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657324001758 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657324001759 Transposase; Region: DEDD_Tnp_IS110; pfam01548 657324001760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 657324001761 Transposase; Region: DEDD_Tnp_IS110; pfam01548 657324001762 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 657324001763 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 657324001764 helix-hairpin-helix signature motif; other site 657324001765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657324001766 dimerization interface [polypeptide binding]; other site 657324001767 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324001768 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324001769 dimer interface [polypeptide binding]; other site 657324001770 putative CheW interface [polypeptide binding]; other site 657324001771 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324001772 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657324001773 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 657324001774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657324001775 DNA-binding site [nucleotide binding]; DNA binding site 657324001776 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 657324001777 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324001778 L-arabinose isomerase; Provisional; Region: PRK02929 657324001779 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 657324001780 hexamer (dimer of trimers) interface [polypeptide binding]; other site 657324001781 trimer interface [polypeptide binding]; other site 657324001782 substrate binding site [chemical binding]; other site 657324001783 Mn binding site [ion binding]; other site 657324001784 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 657324001785 active site 657324001786 intersubunit interactions; other site 657324001787 catalytic residue [active] 657324001788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 657324001789 nucleotide binding site [chemical binding]; other site 657324001790 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 657324001791 nucleotide binding site [chemical binding]; other site 657324001792 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 657324001793 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 657324001794 intersubunit interface [polypeptide binding]; other site 657324001795 active site 657324001796 Zn2+ binding site [ion binding]; other site 657324001797 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 657324001798 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 657324001799 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 657324001800 catalytic residues [active] 657324001801 dimer interface [polypeptide binding]; other site 657324001802 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 657324001803 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 657324001804 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 657324001805 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 657324001806 guanine deaminase; Region: guan_deamin; TIGR02967 657324001807 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 657324001808 active site 657324001809 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 657324001810 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 657324001811 core domain interface [polypeptide binding]; other site 657324001812 delta subunit interface [polypeptide binding]; other site 657324001813 epsilon subunit interface [polypeptide binding]; other site 657324001814 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 657324001815 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 657324001816 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 657324001817 alpha subunit interaction interface [polypeptide binding]; other site 657324001818 Walker A motif; other site 657324001819 ATP binding site [chemical binding]; other site 657324001820 Walker B motif; other site 657324001821 inhibitor binding site; inhibition site 657324001822 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 657324001823 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 657324001824 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 657324001825 gamma subunit interface [polypeptide binding]; other site 657324001826 epsilon subunit interface [polypeptide binding]; other site 657324001827 LBP interface [polypeptide binding]; other site 657324001828 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 657324001829 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657324001830 Methyltransferase domain; Region: Methyltransf_23; pfam13489 657324001831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324001832 S-adenosylmethionine binding site [chemical binding]; other site 657324001833 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 657324001834 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 657324001835 dimerization interface [polypeptide binding]; other site 657324001836 domain crossover interface; other site 657324001837 redox-dependent activation switch; other site 657324001838 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 657324001839 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 657324001840 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 657324001841 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 657324001842 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 657324001843 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 657324001844 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 657324001845 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 657324001846 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 657324001847 primosomal protein N' Region: priA; TIGR00595 657324001848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657324001849 putative Mg++ binding site [ion binding]; other site 657324001850 helicase superfamily c-terminal domain; Region: HELICc; smart00490 657324001851 ATP-binding site [chemical binding]; other site 657324001852 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 657324001853 active site 657324001854 catalytic residues [active] 657324001855 metal binding site [ion binding]; metal-binding site 657324001856 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 657324001857 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 657324001858 putative active site [active] 657324001859 substrate binding site [chemical binding]; other site 657324001860 putative cosubstrate binding site; other site 657324001861 catalytic site [active] 657324001862 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 657324001863 substrate binding site [chemical binding]; other site 657324001864 16S rRNA methyltransferase B; Provisional; Region: PRK14902 657324001865 NusB family; Region: NusB; pfam01029 657324001866 putative RNA binding site [nucleotide binding]; other site 657324001867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324001868 S-adenosylmethionine binding site [chemical binding]; other site 657324001869 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 657324001870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324001871 FeS/SAM binding site; other site 657324001872 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 657324001873 Protein phosphatase 2C; Region: PP2C; pfam00481 657324001874 active site 657324001875 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 657324001876 Catalytic domain of Protein Kinases; Region: PKc; cd00180 657324001877 active site 657324001878 ATP binding site [chemical binding]; other site 657324001879 substrate binding site [chemical binding]; other site 657324001880 activation loop (A-loop); other site 657324001881 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 657324001882 GTPase RsgA; Reviewed; Region: PRK00098 657324001883 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 657324001884 RNA binding site [nucleotide binding]; other site 657324001885 homodimer interface [polypeptide binding]; other site 657324001886 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 657324001887 GTPase/Zn-binding domain interface [polypeptide binding]; other site 657324001888 GTP/Mg2+ binding site [chemical binding]; other site 657324001889 G4 box; other site 657324001890 G5 box; other site 657324001891 G1 box; other site 657324001892 Switch I region; other site 657324001893 G2 box; other site 657324001894 G3 box; other site 657324001895 Switch II region; other site 657324001896 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 657324001897 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 657324001898 substrate binding site [chemical binding]; other site 657324001899 hexamer interface [polypeptide binding]; other site 657324001900 metal binding site [ion binding]; metal-binding site 657324001901 Thiamine pyrophosphokinase; Region: TPK; cd07995 657324001902 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 657324001903 active site 657324001904 dimerization interface [polypeptide binding]; other site 657324001905 thiamine binding site [chemical binding]; other site 657324001906 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 657324001907 active site 657324001908 catalytic triad [active] 657324001909 oxyanion hole [active] 657324001910 Heavy-metal-associated domain; Region: HMA; pfam00403 657324001911 metal-binding site [ion binding] 657324001912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657324001913 dimerization interface [polypeptide binding]; other site 657324001914 putative DNA binding site [nucleotide binding]; other site 657324001915 putative Zn2+ binding site [ion binding]; other site 657324001916 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 657324001917 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 657324001918 Radical SAM superfamily; Region: Radical_SAM; pfam04055 657324001919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324001920 FeS/SAM binding site; other site 657324001921 shikimate kinase; Reviewed; Region: aroK; PRK00131 657324001922 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 657324001923 ADP binding site [chemical binding]; other site 657324001924 magnesium binding site [ion binding]; other site 657324001925 putative shikimate binding site; other site 657324001926 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 657324001927 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 657324001928 Cupin domain; Region: Cupin_2; pfam07883 657324001929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324001930 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657324001931 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 657324001932 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 657324001933 Walker A/P-loop; other site 657324001934 ATP binding site [chemical binding]; other site 657324001935 Q-loop/lid; other site 657324001936 ABC transporter signature motif; other site 657324001937 Walker B; other site 657324001938 D-loop; other site 657324001939 H-loop/switch region; other site 657324001940 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 657324001941 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657324001942 ABC-ATPase subunit interface; other site 657324001943 dimer interface [polypeptide binding]; other site 657324001944 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 657324001945 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 657324001946 siderophore binding site; other site 657324001947 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 657324001948 catalytic motif [active] 657324001949 Zn binding site [ion binding]; other site 657324001950 RibD C-terminal domain; Region: RibD_C; cl17279 657324001951 RibD C-terminal domain; Region: RibD_C; cl17279 657324001952 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 657324001953 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 657324001954 Lumazine binding domain; Region: Lum_binding; pfam00677 657324001955 Lumazine binding domain; Region: Lum_binding; pfam00677 657324001956 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 657324001957 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 657324001958 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 657324001959 dimerization interface [polypeptide binding]; other site 657324001960 active site 657324001961 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 657324001962 homopentamer interface [polypeptide binding]; other site 657324001963 active site 657324001964 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 657324001965 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 657324001966 hexamer (dimer of trimers) interface [polypeptide binding]; other site 657324001967 trimer interface [polypeptide binding]; other site 657324001968 substrate binding site [chemical binding]; other site 657324001969 Mn binding site [ion binding]; other site 657324001970 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 657324001971 N- and C-terminal domain interface [polypeptide binding]; other site 657324001972 D-xylulose kinase; Region: XylB; TIGR01312 657324001973 active site 657324001974 MgATP binding site [chemical binding]; other site 657324001975 catalytic site [active] 657324001976 metal binding site [ion binding]; metal-binding site 657324001977 xylulose binding site [chemical binding]; other site 657324001978 homodimer interface [polypeptide binding]; other site 657324001979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657324001980 putative DNA binding site [nucleotide binding]; other site 657324001981 dimerization interface [polypeptide binding]; other site 657324001982 putative Zn2+ binding site [ion binding]; other site 657324001983 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657324001984 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 657324001985 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 657324001986 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 657324001987 Walker A/P-loop; other site 657324001988 ATP binding site [chemical binding]; other site 657324001989 Q-loop/lid; other site 657324001990 ABC transporter signature motif; other site 657324001991 Walker B; other site 657324001992 D-loop; other site 657324001993 H-loop/switch region; other site 657324001994 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324001995 Walker A/P-loop; other site 657324001996 ATP binding site [chemical binding]; other site 657324001997 Q-loop/lid; other site 657324001998 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 657324001999 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 657324002000 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 657324002001 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 657324002002 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324002003 TM-ABC transporter signature motif; other site 657324002004 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 657324002005 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 657324002006 putative ligand binding site [chemical binding]; other site 657324002007 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324002008 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657324002009 active site 657324002010 motif I; other site 657324002011 motif II; other site 657324002012 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657324002013 dimerization interface [polypeptide binding]; other site 657324002014 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 657324002015 putative active cleft [active] 657324002016 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 657324002017 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 657324002018 ligand binding site; other site 657324002019 oligomer interface; other site 657324002020 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 657324002021 dimer interface [polypeptide binding]; other site 657324002022 N-terminal domain interface [polypeptide binding]; other site 657324002023 sulfate 1 binding site; other site 657324002024 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657324002025 active site 657324002026 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657324002027 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 657324002028 dimer interface [polypeptide binding]; other site 657324002029 N-terminal domain interface [polypeptide binding]; other site 657324002030 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 657324002031 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 657324002032 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 657324002033 active site 657324002034 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 657324002035 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 657324002036 active site 657324002037 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 657324002038 active site 657324002039 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 657324002040 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 657324002041 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 657324002042 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 657324002043 domain interfaces; other site 657324002044 active site 657324002045 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 657324002046 metal binding site [ion binding]; metal-binding site 657324002047 ligand binding site [chemical binding]; other site 657324002048 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 657324002049 ligand binding site [chemical binding]; other site 657324002050 metal binding site [ion binding]; metal-binding site 657324002051 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 657324002052 metal binding site [ion binding]; metal-binding site 657324002053 ligand binding site [chemical binding]; other site 657324002054 Cellulose binding domain; Region: CBM_2; cl17741 657324002055 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 657324002056 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 657324002057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324002058 non-specific DNA binding site [nucleotide binding]; other site 657324002059 salt bridge; other site 657324002060 sequence-specific DNA binding site [nucleotide binding]; other site 657324002061 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 657324002062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657324002063 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657324002064 ABC transporter; Region: ABC_tran_2; pfam12848 657324002065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657324002066 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 657324002067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324002068 salt bridge; other site 657324002069 non-specific DNA binding site [nucleotide binding]; other site 657324002070 sequence-specific DNA binding site [nucleotide binding]; other site 657324002071 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 657324002072 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324002073 Zn2+ binding site [ion binding]; other site 657324002074 Mg2+ binding site [ion binding]; other site 657324002075 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 657324002076 synthetase active site [active] 657324002077 NTP binding site [chemical binding]; other site 657324002078 metal binding site [ion binding]; metal-binding site 657324002079 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 657324002080 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 657324002081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 657324002082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 657324002083 coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994 657324002084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324002085 FeS/SAM binding site; other site 657324002086 histidyl-tRNA synthetase; Region: hisS; TIGR00442 657324002087 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 657324002088 dimer interface [polypeptide binding]; other site 657324002089 motif 1; other site 657324002090 active site 657324002091 motif 2; other site 657324002092 motif 3; other site 657324002093 Haemolysin-III related; Region: HlyIII; cl03831 657324002094 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657324002095 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 657324002096 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 657324002097 homodimer interface [polypeptide binding]; other site 657324002098 substrate-cofactor binding pocket; other site 657324002099 catalytic residue [active] 657324002100 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 657324002101 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324002102 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324002103 metal binding site [ion binding]; metal-binding site 657324002104 active site 657324002105 I-site; other site 657324002106 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 657324002107 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 657324002108 dimer interface [polypeptide binding]; other site 657324002109 active site 657324002110 glycine-pyridoxal phosphate binding site [chemical binding]; other site 657324002111 folate binding site [chemical binding]; other site 657324002112 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 657324002113 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 657324002114 active site 657324002115 catalytic site [active] 657324002116 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657324002117 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 657324002118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657324002119 4Fe-4S binding domain; Region: Fer4; pfam00037 657324002120 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 657324002121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324002122 non-specific DNA binding site [nucleotide binding]; other site 657324002123 salt bridge; other site 657324002124 sequence-specific DNA binding site [nucleotide binding]; other site 657324002125 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657324002126 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 657324002127 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 657324002128 Cation transport protein; Region: TrkH; cl17365 657324002129 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 657324002130 TrkA-N domain; Region: TrkA_N; pfam02254 657324002131 TrkA-C domain; Region: TrkA_C; pfam02080 657324002132 TrkA-N domain; Region: TrkA_N; pfam02254 657324002133 TrkA-C domain; Region: TrkA_C; pfam02080 657324002134 GMP synthase; Reviewed; Region: guaA; PRK00074 657324002135 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 657324002136 AMP/PPi binding site [chemical binding]; other site 657324002137 candidate oxyanion hole; other site 657324002138 catalytic triad [active] 657324002139 potential glutamine specificity residues [chemical binding]; other site 657324002140 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 657324002141 ATP Binding subdomain [chemical binding]; other site 657324002142 Ligand Binding sites [chemical binding]; other site 657324002143 Dimerization subdomain; other site 657324002144 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 657324002145 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 657324002146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324002147 Coenzyme A binding pocket [chemical binding]; other site 657324002148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324002149 Zn2+ binding site [ion binding]; other site 657324002150 Mg2+ binding site [ion binding]; other site 657324002151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324002152 Coenzyme A binding pocket [chemical binding]; other site 657324002153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 657324002154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324002155 Coenzyme A binding pocket [chemical binding]; other site 657324002156 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 657324002157 adenosine deaminase; Provisional; Region: PRK09358 657324002158 active site 657324002159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324002160 Coenzyme A binding pocket [chemical binding]; other site 657324002161 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657324002162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324002163 Coenzyme A binding pocket [chemical binding]; other site 657324002164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324002165 Radical SAM superfamily; Region: Radical_SAM; pfam04055 657324002166 FeS/SAM binding site; other site 657324002167 Protein of unknown function DUF89; Region: DUF89; cl15397 657324002168 Protein of unknown function DUF89; Region: DUF89; cl15397 657324002169 endonuclease IV; Provisional; Region: PRK01060 657324002170 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 657324002171 AP (apurinic/apyrimidinic) site pocket; other site 657324002172 DNA interaction; other site 657324002173 Metal-binding active site; metal-binding site 657324002174 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 657324002175 Protein of unknown function (DUF419); Region: DUF419; pfam04237 657324002176 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 657324002177 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 657324002178 active site 657324002179 DNA binding site [nucleotide binding] 657324002180 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 657324002181 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 657324002182 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 657324002183 DNA binding residues [nucleotide binding] 657324002184 dimer interface [polypeptide binding]; other site 657324002185 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 657324002186 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 657324002187 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 657324002188 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 657324002189 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 657324002190 ArsC family; Region: ArsC; pfam03960 657324002191 putative ArsC-like catalytic residues; other site 657324002192 putative TRX-like catalytic residues [active] 657324002193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324002194 S-adenosylmethionine binding site [chemical binding]; other site 657324002195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657324002196 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 657324002197 Rubredoxin [Energy production and conversion]; Region: COG1773 657324002198 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 657324002199 iron binding site [ion binding]; other site 657324002200 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 657324002201 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 657324002202 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657324002203 catalytic core [active] 657324002204 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 657324002205 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 657324002206 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 657324002207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324002208 Coenzyme A binding pocket [chemical binding]; other site 657324002209 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 657324002210 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657324002211 putative metal binding site [ion binding]; other site 657324002212 Predicted esterase [General function prediction only]; Region: COG0627 657324002213 S-formylglutathione hydrolase; Region: PLN02442 657324002214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324002215 S-adenosylmethionine binding site [chemical binding]; other site 657324002216 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 657324002217 nudix motif; other site 657324002218 AAA domain; Region: AAA_33; pfam13671 657324002219 AAA domain; Region: AAA_17; pfam13207 657324002220 maltose O-acetyltransferase; Provisional; Region: PRK10092 657324002221 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 657324002222 active site 657324002223 substrate binding site [chemical binding]; other site 657324002224 trimer interface [polypeptide binding]; other site 657324002225 CoA binding site [chemical binding]; other site 657324002226 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 657324002227 putative dimer interface [polypeptide binding]; other site 657324002228 catalytic triad [active] 657324002229 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 657324002230 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 657324002231 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 657324002232 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324002233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324002234 metal binding site [ion binding]; metal-binding site 657324002235 active site 657324002236 I-site; other site 657324002237 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324002238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324002239 non-specific DNA binding site [nucleotide binding]; other site 657324002240 salt bridge; other site 657324002241 sequence-specific DNA binding site [nucleotide binding]; other site 657324002242 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 657324002243 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 657324002244 Transcriptional regulators [Transcription]; Region: GntR; COG1802 657324002245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657324002246 DNA-binding site [nucleotide binding]; DNA binding site 657324002247 FCD domain; Region: FCD; pfam07729 657324002248 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657324002249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002250 dimer interface [polypeptide binding]; other site 657324002251 conserved gate region; other site 657324002252 ABC-ATPase subunit interface; other site 657324002253 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324002254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002255 dimer interface [polypeptide binding]; other site 657324002256 conserved gate region; other site 657324002257 putative PBP binding loops; other site 657324002258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 657324002259 ABC-ATPase subunit interface; other site 657324002260 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324002261 Protein of unknown function, DUF624; Region: DUF624; pfam04854 657324002262 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 657324002263 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 657324002264 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 657324002265 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 657324002266 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 657324002267 active site 657324002268 catalytic triad [active] 657324002269 oxyanion hole [active] 657324002270 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 657324002271 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 657324002272 inhibitor binding site; inhibition site 657324002273 active site 657324002274 Histidine kinase; Region: His_kinase; pfam06580 657324002275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324002276 ATP binding site [chemical binding]; other site 657324002277 Mg2+ binding site [ion binding]; other site 657324002278 G-X-G motif; other site 657324002279 Response regulator receiver domain; Region: Response_reg; pfam00072 657324002280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324002281 active site 657324002282 phosphorylation site [posttranslational modification] 657324002283 intermolecular recognition site; other site 657324002284 dimerization interface [polypeptide binding]; other site 657324002285 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 657324002286 Helix-turn-helix domain; Region: HTH_18; pfam12833 657324002287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324002288 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324002289 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657324002290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002291 dimer interface [polypeptide binding]; other site 657324002292 conserved gate region; other site 657324002293 putative PBP binding loops; other site 657324002294 ABC-ATPase subunit interface; other site 657324002295 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324002296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002297 dimer interface [polypeptide binding]; other site 657324002298 conserved gate region; other site 657324002299 ABC-ATPase subunit interface; other site 657324002300 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 657324002301 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 657324002302 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 657324002303 active site 657324002304 substrate binding site [chemical binding]; other site 657324002305 metal binding site [ion binding]; metal-binding site 657324002306 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 657324002307 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 657324002308 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 657324002309 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 657324002310 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 657324002311 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 657324002312 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657324002313 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 657324002314 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 657324002315 active site 657324002316 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 657324002317 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 657324002318 dimer interface [polypeptide binding]; other site 657324002319 PYR/PP interface [polypeptide binding]; other site 657324002320 TPP binding site [chemical binding]; other site 657324002321 substrate binding site [chemical binding]; other site 657324002322 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 657324002323 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 657324002324 Domain of unknown function; Region: EKR; pfam10371 657324002325 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657324002326 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 657324002327 TPP-binding site [chemical binding]; other site 657324002328 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 657324002329 ATP cone domain; Region: ATP-cone; pfam03477 657324002330 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 657324002331 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 657324002332 active site 657324002333 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 657324002334 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 657324002335 active site 657324002336 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 657324002337 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 657324002338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324002339 active site 657324002340 motif I; other site 657324002341 motif II; other site 657324002342 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 657324002343 trigger factor; Provisional; Region: tig; PRK01490 657324002344 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 657324002345 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 657324002346 Clp protease; Region: CLP_protease; pfam00574 657324002347 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 657324002348 oligomer interface [polypeptide binding]; other site 657324002349 active site residues [active] 657324002350 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 657324002351 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 657324002352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324002353 Walker A motif; other site 657324002354 ATP binding site [chemical binding]; other site 657324002355 Walker B motif; other site 657324002356 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 657324002357 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 657324002358 G1 box; other site 657324002359 GTP/Mg2+ binding site [chemical binding]; other site 657324002360 Switch I region; other site 657324002361 G2 box; other site 657324002362 G3 box; other site 657324002363 Switch II region; other site 657324002364 G4 box; other site 657324002365 G5 box; other site 657324002366 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 657324002367 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 657324002368 intersubunit interface [polypeptide binding]; other site 657324002369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324002370 non-specific DNA binding site [nucleotide binding]; other site 657324002371 salt bridge; other site 657324002372 sequence-specific DNA binding site [nucleotide binding]; other site 657324002373 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 657324002374 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 657324002375 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 657324002376 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657324002377 ABC-ATPase subunit interface; other site 657324002378 dimer interface [polypeptide binding]; other site 657324002379 putative PBP binding regions; other site 657324002380 HipA N-terminal domain; Region: Couple_hipA; pfam13657 657324002381 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 657324002382 HipA-like N-terminal domain; Region: HipA_N; pfam07805 657324002383 HipA-like C-terminal domain; Region: HipA_C; pfam07804 657324002384 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657324002385 flagellin; Validated; Region: PRK08026 657324002386 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 657324002387 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657324002388 flagellin; Validated; Region: PRK08026 657324002389 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 657324002390 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657324002391 active site 657324002392 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 657324002393 homodimer interaction site [polypeptide binding]; other site 657324002394 cofactor binding site; other site 657324002395 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657324002396 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657324002397 active site 657324002398 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 657324002399 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 657324002400 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 657324002401 GTP-binding protein YchF; Reviewed; Region: PRK09601 657324002402 YchF GTPase; Region: YchF; cd01900 657324002403 G1 box; other site 657324002404 GTP/Mg2+ binding site [chemical binding]; other site 657324002405 Switch I region; other site 657324002406 G2 box; other site 657324002407 Switch II region; other site 657324002408 G3 box; other site 657324002409 G4 box; other site 657324002410 G5 box; other site 657324002411 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 657324002412 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 657324002413 peptidase T; Region: peptidase-T; TIGR01882 657324002414 metal binding site [ion binding]; metal-binding site 657324002415 dimer interface [polypeptide binding]; other site 657324002416 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657324002417 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657324002418 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657324002419 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 657324002420 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 657324002421 ATP-binding site [chemical binding]; other site 657324002422 Sugar specificity; other site 657324002423 Pyrimidine base specificity; other site 657324002424 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 657324002425 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657324002426 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 657324002427 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657324002428 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657324002429 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657324002430 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 657324002431 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; cl11685 657324002432 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 657324002433 4Fe-4S binding domain; Region: Fer4; pfam00037 657324002434 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 657324002435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657324002436 4Fe-4S binding domain; Region: Fer4; cl02805 657324002437 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 657324002438 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 657324002439 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 657324002440 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 657324002441 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 657324002442 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 657324002443 catalytic residues [active] 657324002444 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 657324002445 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 657324002446 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 657324002447 HSP70 interaction site [polypeptide binding]; other site 657324002448 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 657324002449 putative DNA binding helix; other site 657324002450 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 657324002451 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 657324002452 dimer interface [polypeptide binding]; other site 657324002453 anticodon binding site; other site 657324002454 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 657324002455 homodimer interface [polypeptide binding]; other site 657324002456 motif 1; other site 657324002457 active site 657324002458 motif 2; other site 657324002459 GAD domain; Region: GAD; pfam02938 657324002460 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 657324002461 active site 657324002462 motif 3; other site 657324002463 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 657324002464 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 657324002465 Na binding site [ion binding]; other site 657324002466 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 657324002467 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 657324002468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657324002469 DNA-binding site [nucleotide binding]; DNA binding site 657324002470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657324002471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324002472 homodimer interface [polypeptide binding]; other site 657324002473 catalytic residue [active] 657324002474 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657324002475 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657324002476 substrate binding pocket [chemical binding]; other site 657324002477 membrane-bound complex binding site; other site 657324002478 hinge residues; other site 657324002479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002480 dimer interface [polypeptide binding]; other site 657324002481 conserved gate region; other site 657324002482 putative PBP binding loops; other site 657324002483 ABC-ATPase subunit interface; other site 657324002484 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657324002485 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 657324002486 Walker A/P-loop; other site 657324002487 ATP binding site [chemical binding]; other site 657324002488 Q-loop/lid; other site 657324002489 ABC transporter signature motif; other site 657324002490 Walker B; other site 657324002491 D-loop; other site 657324002492 H-loop/switch region; other site 657324002493 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 657324002494 putative substrate binding site 1 [chemical binding]; other site 657324002495 Na binding site 1 [ion binding]; other site 657324002496 Na2 binding site [ion binding]; other site 657324002497 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657324002498 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657324002499 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 657324002500 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 657324002501 G1 box; other site 657324002502 GTP/Mg2+ binding site [chemical binding]; other site 657324002503 Switch I region; other site 657324002504 G2 box; other site 657324002505 G3 box; other site 657324002506 Switch II region; other site 657324002507 G4 box; other site 657324002508 G5 box; other site 657324002509 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 657324002510 Nucleoside recognition; Region: Gate; pfam07670 657324002511 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 657324002512 Nucleoside recognition; Region: Gate; pfam07670 657324002513 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657324002514 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657324002515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324002516 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 657324002517 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657324002518 active site turn [active] 657324002519 phosphorylation site [posttranslational modification] 657324002520 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657324002521 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 657324002522 HPr interaction site; other site 657324002523 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657324002524 active site 657324002525 phosphorylation site [posttranslational modification] 657324002526 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 657324002527 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 657324002528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657324002529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324002530 active site 657324002531 phosphorylation site [posttranslational modification] 657324002532 intermolecular recognition site; other site 657324002533 dimerization interface [polypeptide binding]; other site 657324002534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657324002535 DNA binding site [nucleotide binding] 657324002536 macrolide transporter subunit MacA; Provisional; Region: PRK11578 657324002537 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657324002538 FtsX-like permease family; Region: FtsX; pfam02687 657324002539 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324002540 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324002541 DNA binding site [nucleotide binding] 657324002542 domain linker motif; other site 657324002543 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 657324002544 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 657324002545 starch binding site [chemical binding]; other site 657324002546 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 657324002547 homodimer interface [polypeptide binding]; other site 657324002548 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 657324002549 active site 657324002550 homodimer interface [polypeptide binding]; other site 657324002551 catalytic site [active] 657324002552 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 657324002553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002554 dimer interface [polypeptide binding]; other site 657324002555 conserved gate region; other site 657324002556 ABC-ATPase subunit interface; other site 657324002557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324002558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002559 dimer interface [polypeptide binding]; other site 657324002560 conserved gate region; other site 657324002561 putative PBP binding loops; other site 657324002562 ABC-ATPase subunit interface; other site 657324002563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324002564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324002565 DNA binding site [nucleotide binding] 657324002566 domain linker motif; other site 657324002567 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657324002568 dimerization interface [polypeptide binding]; other site 657324002569 ligand binding site [chemical binding]; other site 657324002570 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 657324002571 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657324002572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002573 dimer interface [polypeptide binding]; other site 657324002574 conserved gate region; other site 657324002575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 657324002576 ABC-ATPase subunit interface; other site 657324002577 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002579 dimer interface [polypeptide binding]; other site 657324002580 conserved gate region; other site 657324002581 ABC-ATPase subunit interface; other site 657324002582 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 657324002583 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 657324002584 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 657324002585 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324002586 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324002587 dimer interface [polypeptide binding]; other site 657324002588 putative CheW interface [polypeptide binding]; other site 657324002589 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 657324002590 active site 657324002591 NAD binding site [chemical binding]; other site 657324002592 metal binding site [ion binding]; metal-binding site 657324002593 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 657324002594 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 657324002595 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 657324002596 N- and C-terminal domain interface [polypeptide binding]; other site 657324002597 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 657324002598 active site 657324002599 putative catalytic site [active] 657324002600 metal binding site [ion binding]; metal-binding site 657324002601 ATP binding site [chemical binding]; other site 657324002602 carbohydrate binding site [chemical binding]; other site 657324002603 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 657324002604 hexamer (dimer of trimers) interface [polypeptide binding]; other site 657324002605 substrate binding site [chemical binding]; other site 657324002606 trimer interface [polypeptide binding]; other site 657324002607 Mn binding site [ion binding]; other site 657324002608 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 657324002609 intersubunit interface [polypeptide binding]; other site 657324002610 active site 657324002611 Zn2+ binding site [ion binding]; other site 657324002612 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 657324002613 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 657324002614 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657324002615 catalytic residue [active] 657324002616 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 657324002617 trimerization site [polypeptide binding]; other site 657324002618 active site 657324002619 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 657324002620 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 657324002621 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 657324002622 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 657324002623 Ligand Binding Site [chemical binding]; other site 657324002624 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 657324002625 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 657324002626 putative ATP binding site [chemical binding]; other site 657324002627 putative substrate interface [chemical binding]; other site 657324002628 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657324002629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657324002630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657324002631 dimerization interface [polypeptide binding]; other site 657324002632 Transcriptional regulator; Region: Rrf2; cl17282 657324002633 Rrf2 family protein; Region: rrf2_super; TIGR00738 657324002634 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 657324002635 active site 657324002636 catalytic triad [active] 657324002637 oxyanion hole [active] 657324002638 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 657324002639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657324002640 substrate binding pocket [chemical binding]; other site 657324002641 membrane-bound complex binding site; other site 657324002642 hinge residues; other site 657324002643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 657324002644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002645 dimer interface [polypeptide binding]; other site 657324002646 ABC-ATPase subunit interface; other site 657324002647 putative PBP binding loops; other site 657324002648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002649 dimer interface [polypeptide binding]; other site 657324002650 conserved gate region; other site 657324002651 putative PBP binding loops; other site 657324002652 ABC-ATPase subunit interface; other site 657324002653 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657324002654 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 657324002655 Walker A/P-loop; other site 657324002656 ATP binding site [chemical binding]; other site 657324002657 Q-loop/lid; other site 657324002658 ABC transporter signature motif; other site 657324002659 Walker B; other site 657324002660 D-loop; other site 657324002661 H-loop/switch region; other site 657324002662 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 657324002663 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324002664 dimer interface [polypeptide binding]; other site 657324002665 putative CheW interface [polypeptide binding]; other site 657324002666 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 657324002667 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657324002668 Walker A/P-loop; other site 657324002669 ATP binding site [chemical binding]; other site 657324002670 Q-loop/lid; other site 657324002671 ABC transporter signature motif; other site 657324002672 Walker B; other site 657324002673 D-loop; other site 657324002674 H-loop/switch region; other site 657324002675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002676 dimer interface [polypeptide binding]; other site 657324002677 conserved gate region; other site 657324002678 ABC-ATPase subunit interface; other site 657324002679 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 657324002680 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 657324002681 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 657324002682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324002683 non-specific DNA binding site [nucleotide binding]; other site 657324002684 salt bridge; other site 657324002685 sequence-specific DNA binding site [nucleotide binding]; other site 657324002686 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 657324002687 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 657324002688 substrate binding pocket [chemical binding]; other site 657324002689 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 657324002690 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 657324002691 putative homodimer interface [polypeptide binding]; other site 657324002692 putative homotetramer interface [polypeptide binding]; other site 657324002693 putative allosteric switch controlling residues; other site 657324002694 putative metal binding site [ion binding]; other site 657324002695 putative homodimer-homodimer interface [polypeptide binding]; other site 657324002696 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 657324002697 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 657324002698 metal-binding site [ion binding] 657324002699 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657324002700 Soluble P-type ATPase [General function prediction only]; Region: COG4087 657324002701 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 657324002702 metal-binding site [ion binding] 657324002703 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 657324002704 S-adenosylmethionine synthetase; Validated; Region: PRK05250 657324002705 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 657324002706 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 657324002707 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 657324002708 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657324002709 nitrogenase iron protein; Region: nifH; TIGR01287 657324002710 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 657324002711 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 657324002712 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 657324002713 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 657324002714 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 657324002715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 657324002716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657324002717 substrate binding pocket [chemical binding]; other site 657324002718 membrane-bound complex binding site; other site 657324002719 hinge residues; other site 657324002720 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 657324002721 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 657324002722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002723 dimer interface [polypeptide binding]; other site 657324002724 conserved gate region; other site 657324002725 putative PBP binding loops; other site 657324002726 ABC-ATPase subunit interface; other site 657324002727 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 657324002728 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 657324002729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324002730 Walker A/P-loop; other site 657324002731 ATP binding site [chemical binding]; other site 657324002732 Q-loop/lid; other site 657324002733 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 657324002734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324002735 ABC transporter signature motif; other site 657324002736 Walker B; other site 657324002737 D-loop; other site 657324002738 H-loop/switch region; other site 657324002739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324002740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324002741 non-specific DNA binding site [nucleotide binding]; other site 657324002742 salt bridge; other site 657324002743 sequence-specific DNA binding site [nucleotide binding]; other site 657324002744 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 657324002745 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 657324002746 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 657324002747 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 657324002748 homodimer interface [polypeptide binding]; other site 657324002749 substrate-cofactor binding pocket; other site 657324002750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324002751 catalytic residue [active] 657324002752 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 657324002753 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 657324002754 4Fe-4S binding domain; Region: Fer4_6; pfam12837 657324002755 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 657324002756 CPxP motif; other site 657324002757 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 657324002758 catalytic residues [active] 657324002759 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 657324002760 thiS-thiF/thiG interaction site; other site 657324002761 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 657324002762 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 657324002763 ATP binding site [chemical binding]; other site 657324002764 substrate interface [chemical binding]; other site 657324002765 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 657324002766 MPN+ (JAMM) motif; other site 657324002767 Zinc-binding site [ion binding]; other site 657324002768 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 657324002769 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 657324002770 domain interfaces; other site 657324002771 active site 657324002772 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 657324002773 active site 657324002774 SAM binding site [chemical binding]; other site 657324002775 homodimer interface [polypeptide binding]; other site 657324002776 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 657324002777 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 657324002778 active site 657324002779 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 657324002780 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 657324002781 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 657324002782 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 657324002783 homodimer interface [polypeptide binding]; other site 657324002784 substrate-cofactor binding pocket; other site 657324002785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324002786 catalytic residue [active] 657324002787 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 657324002788 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 657324002789 dimer interface [polypeptide binding]; other site 657324002790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324002791 catalytic residue [active] 657324002792 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 657324002793 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 657324002794 G1 box; other site 657324002795 GTP/Mg2+ binding site [chemical binding]; other site 657324002796 Switch I region; other site 657324002797 G2 box; other site 657324002798 G3 box; other site 657324002799 Switch II region; other site 657324002800 G4 box; other site 657324002801 G5 box; other site 657324002802 Nucleoside recognition; Region: Gate; pfam07670 657324002803 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 657324002804 Nucleoside recognition; Region: Gate; pfam07670 657324002805 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324002806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657324002807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002808 dimer interface [polypeptide binding]; other site 657324002809 conserved gate region; other site 657324002810 putative PBP binding loops; other site 657324002811 ABC-ATPase subunit interface; other site 657324002812 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324002813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002814 dimer interface [polypeptide binding]; other site 657324002815 conserved gate region; other site 657324002816 putative PBP binding loops; other site 657324002817 ABC-ATPase subunit interface; other site 657324002818 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 657324002819 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 657324002820 active site 657324002821 homodimer interface [polypeptide binding]; other site 657324002822 catalytic site [active] 657324002823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324002824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324002825 DNA binding site [nucleotide binding] 657324002826 domain linker motif; other site 657324002827 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324002828 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657324002829 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 657324002830 putative substrate binding site [chemical binding]; other site 657324002831 putative ATP binding site [chemical binding]; other site 657324002832 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 657324002833 Sodium Bile acid symporter family; Region: SBF; pfam01758 657324002834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 657324002835 active site 657324002836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 657324002837 N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749 657324002838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324002839 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657324002840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324002841 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324002842 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324002843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002844 dimer interface [polypeptide binding]; other site 657324002845 conserved gate region; other site 657324002846 putative PBP binding loops; other site 657324002847 ABC-ATPase subunit interface; other site 657324002848 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 657324002849 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 657324002850 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 657324002851 putative active site [active] 657324002852 putative catalytic site [active] 657324002853 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324002854 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324002855 DNA binding site [nucleotide binding] 657324002856 domain linker motif; other site 657324002857 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657324002858 dimerization interface [polypeptide binding]; other site 657324002859 ligand binding site [chemical binding]; other site 657324002860 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657324002861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324002862 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 657324002863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002864 dimer interface [polypeptide binding]; other site 657324002865 conserved gate region; other site 657324002866 putative PBP binding loops; other site 657324002867 ABC-ATPase subunit interface; other site 657324002868 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324002869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002870 dimer interface [polypeptide binding]; other site 657324002871 conserved gate region; other site 657324002872 putative PBP binding loops; other site 657324002873 ABC-ATPase subunit interface; other site 657324002874 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 657324002875 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 657324002876 active site 657324002877 Ca binding site [ion binding]; other site 657324002878 catalytic site [active] 657324002879 Aamy_C domain; Region: Aamy_C; smart00632 657324002880 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 657324002881 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 657324002882 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 657324002883 putative RNA binding site [nucleotide binding]; other site 657324002884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324002885 S-adenosylmethionine binding site [chemical binding]; other site 657324002886 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 657324002887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324002888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324002889 Walker A/P-loop; other site 657324002890 Walker A/P-loop; other site 657324002891 ATP binding site [chemical binding]; other site 657324002892 ATP binding site [chemical binding]; other site 657324002893 ABC transporter; Region: ABC_tran; pfam00005 657324002894 Q-loop/lid; other site 657324002895 ABC transporter signature motif; other site 657324002896 Walker B; other site 657324002897 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 657324002898 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 657324002899 flagellin; Provisional; Region: PRK12804 657324002900 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657324002901 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 657324002902 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 657324002903 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 657324002904 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 657324002905 catalytic residues [active] 657324002906 MarR family; Region: MarR_2; cl17246 657324002907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 657324002908 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 657324002909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657324002910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657324002911 dimer interface [polypeptide binding]; other site 657324002912 phosphorylation site [posttranslational modification] 657324002913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324002914 ATP binding site [chemical binding]; other site 657324002915 Mg2+ binding site [ion binding]; other site 657324002916 G-X-G motif; other site 657324002917 Response regulator receiver domain; Region: Response_reg; pfam00072 657324002918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324002919 active site 657324002920 phosphorylation site [posttranslational modification] 657324002921 intermolecular recognition site; other site 657324002922 dimerization interface [polypeptide binding]; other site 657324002923 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 657324002924 active site 657324002925 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 657324002926 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 657324002927 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 657324002928 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657324002929 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657324002930 Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559 657324002931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 657324002932 Histidine kinase; Region: His_kinase; pfam06580 657324002933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324002934 ATP binding site [chemical binding]; other site 657324002935 Mg2+ binding site [ion binding]; other site 657324002936 G-X-G motif; other site 657324002937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324002938 Response regulator receiver domain; Region: Response_reg; pfam00072 657324002939 active site 657324002940 phosphorylation site [posttranslational modification] 657324002941 intermolecular recognition site; other site 657324002942 dimerization interface [polypeptide binding]; other site 657324002943 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 657324002944 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657324002945 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 657324002946 active site 657324002947 catalytic site [active] 657324002948 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 657324002949 active site 657324002950 catalytic site [active] 657324002951 Histidine kinase; Region: His_kinase; pfam06580 657324002952 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 657324002953 ATP binding site [chemical binding]; other site 657324002954 Mg2+ binding site [ion binding]; other site 657324002955 G-X-G motif; other site 657324002956 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 657324002957 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 657324002958 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 657324002959 active site 657324002960 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 657324002961 active site 657324002962 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 657324002963 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 657324002964 active site 657324002965 Predicted transcriptional regulator [Transcription]; Region: COG4189 657324002966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657324002967 dimerization interface [polypeptide binding]; other site 657324002968 putative DNA binding site [nucleotide binding]; other site 657324002969 putative Zn2+ binding site [ion binding]; other site 657324002970 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324002971 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657324002972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002973 dimer interface [polypeptide binding]; other site 657324002974 conserved gate region; other site 657324002975 putative PBP binding loops; other site 657324002976 ABC-ATPase subunit interface; other site 657324002977 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324002978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324002979 dimer interface [polypeptide binding]; other site 657324002980 conserved gate region; other site 657324002981 putative PBP binding loops; other site 657324002982 ABC-ATPase subunit interface; other site 657324002983 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 657324002984 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 657324002985 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 657324002986 UbiA prenyltransferase family; Region: UbiA; pfam01040 657324002987 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 657324002988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657324002989 TQO small subunit DoxD; Region: DoxD; pfam04173 657324002990 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 657324002991 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 657324002992 substrate binding pocket [chemical binding]; other site 657324002993 chain length determination region; other site 657324002994 substrate-Mg2+ binding site; other site 657324002995 catalytic residues [active] 657324002996 aspartate-rich region 1; other site 657324002997 active site lid residues [active] 657324002998 aspartate-rich region 2; other site 657324002999 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 657324003000 ApbE family; Region: ApbE; pfam02424 657324003001 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 657324003002 trimer interface [polypeptide binding]; other site 657324003003 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 657324003004 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 657324003005 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 657324003006 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 657324003007 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 657324003008 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 657324003009 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 657324003010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 657324003011 nucleotide binding region [chemical binding]; other site 657324003012 ATP-binding site [chemical binding]; other site 657324003013 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 657324003014 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324003015 pyruvate phosphate dikinase; Provisional; Region: PRK09279 657324003016 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 657324003017 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 657324003018 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 657324003019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657324003020 putative substrate translocation pore; other site 657324003021 Major Facilitator Superfamily; Region: MFS_1; pfam07690 657324003022 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 657324003023 Divergent AAA domain; Region: AAA_4; pfam04326 657324003024 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 657324003025 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 657324003026 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 657324003027 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 657324003028 DNA binding residues [nucleotide binding] 657324003029 drug binding residues [chemical binding]; other site 657324003030 dimer interface [polypeptide binding]; other site 657324003031 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 657324003032 AAA domain; Region: AAA_14; pfam13173 657324003033 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 657324003034 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 657324003035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324003036 Coenzyme A binding pocket [chemical binding]; other site 657324003037 Predicted transcriptional regulator [Transcription]; Region: COG1959 657324003038 Transcriptional regulator; Region: Rrf2; cl17282 657324003039 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 657324003040 ADP-ribose binding site [chemical binding]; other site 657324003041 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 657324003042 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 657324003043 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324003044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324003045 non-specific DNA binding site [nucleotide binding]; other site 657324003046 salt bridge; other site 657324003047 sequence-specific DNA binding site [nucleotide binding]; other site 657324003048 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 657324003049 Fic/DOC family; Region: Fic; cl00960 657324003050 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 657324003051 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 657324003052 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 657324003053 DNA binding residues [nucleotide binding] 657324003054 dimer interface [polypeptide binding]; other site 657324003055 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 657324003056 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 657324003057 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 657324003058 hypothetical protein; Provisional; Region: PRK03881 657324003059 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 657324003060 AMMECR1; Region: AMMECR1; pfam01871 657324003061 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 657324003062 hypothetical protein; Provisional; Region: PRK11770 657324003063 Domain of unknown function (DUF307); Region: DUF307; pfam03733 657324003064 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 657324003065 HD domain; Region: HD_3; pfam13023 657324003066 TraX protein; Region: TraX; cl05434 657324003067 TraX protein; Region: TraX; cl05434 657324003068 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324003069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324003070 non-specific DNA binding site [nucleotide binding]; other site 657324003071 salt bridge; other site 657324003072 sequence-specific DNA binding site [nucleotide binding]; other site 657324003073 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 657324003074 putative active site [active] 657324003075 putative metal binding site [ion binding]; other site 657324003076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324003077 non-specific DNA binding site [nucleotide binding]; other site 657324003078 salt bridge; other site 657324003079 sequence-specific DNA binding site [nucleotide binding]; other site 657324003080 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 657324003081 active site 657324003082 NTP binding site [chemical binding]; other site 657324003083 metal binding triad [ion binding]; metal-binding site 657324003084 antibiotic binding site [chemical binding]; other site 657324003085 Protein of unknown function DUF86; Region: DUF86; cl01031 657324003086 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 657324003087 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 657324003088 nudix motif; other site 657324003089 HipA-like C-terminal domain; Region: HipA_C; pfam07804 657324003090 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 657324003091 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 657324003092 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 657324003093 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 657324003094 toxin interface [polypeptide binding]; other site 657324003095 Zn binding site [ion binding]; other site 657324003096 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 657324003097 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 657324003098 Helix-turn-helix domain; Region: HTH_17; pfam12728 657324003099 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 657324003100 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 657324003101 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 657324003102 Predicted transcriptional regulator [Transcription]; Region: COG2378 657324003103 WYL domain; Region: WYL; pfam13280 657324003104 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 657324003105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324003106 non-specific DNA binding site [nucleotide binding]; other site 657324003107 salt bridge; other site 657324003108 sequence-specific DNA binding site [nucleotide binding]; other site 657324003109 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 657324003110 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 657324003111 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 657324003112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657324003113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324003114 Coenzyme A binding pocket [chemical binding]; other site 657324003115 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 657324003116 hypothetical protein; Provisional; Region: PRK13795 657324003117 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 657324003118 Active Sites [active] 657324003119 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 657324003120 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 657324003121 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657324003122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657324003123 catalytic residue [active] 657324003124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657324003125 ATP binding site [chemical binding]; other site 657324003126 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 657324003127 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 657324003128 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 657324003129 PLD-like domain; Region: PLDc_2; pfam13091 657324003130 homodimer interface [polypeptide binding]; other site 657324003131 putative active site [active] 657324003132 putative active site [active] 657324003133 catalytic site [active] 657324003134 catalytic site [active] 657324003135 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 657324003136 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 657324003137 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 657324003138 nucleotide binding site [chemical binding]; other site 657324003139 putative NEF/HSP70 interaction site [polypeptide binding]; other site 657324003140 SBD interface [polypeptide binding]; other site 657324003141 Part of AAA domain; Region: AAA_19; pfam13245 657324003142 Family description; Region: UvrD_C_2; pfam13538 657324003143 helicase superfamily c-terminal domain; Region: HELICc; smart00490 657324003144 ATP-binding site [chemical binding]; other site 657324003145 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 657324003146 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 657324003147 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 657324003148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324003149 non-specific DNA binding site [nucleotide binding]; other site 657324003150 salt bridge; other site 657324003151 sequence-specific DNA binding site [nucleotide binding]; other site 657324003152 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 657324003153 Right handed beta helix region; Region: Beta_helix; pfam13229 657324003154 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 657324003155 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 657324003156 non-specific DNA binding site [nucleotide binding]; other site 657324003157 salt bridge; other site 657324003158 sequence-specific DNA binding site [nucleotide binding]; other site 657324003159 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 657324003160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324003161 sequence-specific DNA binding site [nucleotide binding]; other site 657324003162 salt bridge; other site 657324003163 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 657324003164 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 657324003165 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 657324003166 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 657324003167 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 657324003168 active site 657324003169 NAD binding site [chemical binding]; other site 657324003170 metal binding site [ion binding]; metal-binding site 657324003171 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 657324003172 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324003173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324003174 dimer interface [polypeptide binding]; other site 657324003175 putative CheW interface [polypeptide binding]; other site 657324003176 flagellar operon protein TIGR03826; Region: YvyF 657324003177 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657324003178 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657324003179 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657324003180 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657324003181 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 657324003182 MgtE intracellular N domain; Region: MgtE_N; pfam03448 657324003183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 657324003184 Divalent cation transporter; Region: MgtE; pfam01769 657324003185 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 657324003186 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 657324003187 putative active site [active] 657324003188 PhoH-like protein; Region: PhoH; pfam02562 657324003189 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 657324003190 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 657324003191 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 657324003192 homotrimer interaction site [polypeptide binding]; other site 657324003193 zinc binding site [ion binding]; other site 657324003194 CDP-binding sites; other site 657324003195 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 657324003196 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324003197 active site 657324003198 HIGH motif; other site 657324003199 nucleotide binding site [chemical binding]; other site 657324003200 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 657324003201 KMSKS motif; other site 657324003202 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 657324003203 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 657324003204 active site 657324003205 metal binding site [ion binding]; metal-binding site 657324003206 dimerization interface [polypeptide binding]; other site 657324003207 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 657324003208 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 657324003209 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 657324003210 RNA polymerase factor sigma-70; Validated; Region: PRK08295 657324003211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657324003212 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 657324003213 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 657324003214 active site 657324003215 catalytic residue [active] 657324003216 dimer interface [polypeptide binding]; other site 657324003217 Class I aldolases; Region: Aldolase_Class_I; cl17187 657324003218 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657324003219 active site 657324003220 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657324003221 histidinol-phosphatase; Provisional; Region: PRK05588 657324003222 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 657324003223 active site 657324003224 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 657324003225 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 657324003226 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 657324003227 Phosphoglycerate kinase; Region: PGK; pfam00162 657324003228 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 657324003229 substrate binding site [chemical binding]; other site 657324003230 hinge regions; other site 657324003231 ADP binding site [chemical binding]; other site 657324003232 catalytic site [active] 657324003233 triosephosphate isomerase; Provisional; Region: PRK14567 657324003234 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 657324003235 substrate binding site [chemical binding]; other site 657324003236 dimer interface [polypeptide binding]; other site 657324003237 catalytic triad [active] 657324003238 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 657324003239 Sel1-like repeats; Region: SEL1; smart00671 657324003240 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 657324003241 Sel1-like repeats; Region: SEL1; smart00671 657324003242 Sel1-like repeats; Region: SEL1; smart00671 657324003243 Sel1-like repeats; Region: SEL1; smart00671 657324003244 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 657324003245 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 657324003246 putative active site [active] 657324003247 putative metal binding site [ion binding]; other site 657324003248 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 657324003249 phosphoglyceromutase; Provisional; Region: PRK05434 657324003250 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 657324003251 ATP binding site [chemical binding]; other site 657324003252 active site 657324003253 substrate binding site [chemical binding]; other site 657324003254 amidophosphoribosyltransferase; Provisional; Region: PRK05793 657324003255 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 657324003256 active site 657324003257 tetramer interface [polypeptide binding]; other site 657324003258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657324003259 active site 657324003260 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 657324003261 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 657324003262 tetramer interface [polypeptide binding]; other site 657324003263 active site 657324003264 glutamate dehydrogenase; Provisional; Region: PRK09414 657324003265 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 657324003266 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 657324003267 NAD(P) binding site [chemical binding]; other site 657324003268 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 657324003269 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657324003270 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657324003271 Walker A/P-loop; other site 657324003272 ATP binding site [chemical binding]; other site 657324003273 Q-loop/lid; other site 657324003274 ABC transporter signature motif; other site 657324003275 Walker B; other site 657324003276 D-loop; other site 657324003277 H-loop/switch region; other site 657324003278 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657324003279 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 657324003280 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 657324003281 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 657324003282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324003283 catalytic residue [active] 657324003284 Chemotaxis phosphatase CheX; Region: CheX; cl15816 657324003285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324003286 Response regulator receiver domain; Region: Response_reg; pfam00072 657324003287 active site 657324003288 phosphorylation site [posttranslational modification] 657324003289 intermolecular recognition site; other site 657324003290 dimerization interface [polypeptide binding]; other site 657324003291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657324003292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324003293 active site 657324003294 phosphorylation site [posttranslational modification] 657324003295 intermolecular recognition site; other site 657324003296 dimerization interface [polypeptide binding]; other site 657324003297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657324003298 DNA binding site [nucleotide binding] 657324003299 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 657324003300 dimer interface [polypeptide binding]; other site 657324003301 active site 657324003302 citrylCoA binding site [chemical binding]; other site 657324003303 Citrate synthase; Region: Citrate_synt; pfam00285 657324003304 oxalacetate/citrate binding site [chemical binding]; other site 657324003305 coenzyme A binding site [chemical binding]; other site 657324003306 catalytic triad [active] 657324003307 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 657324003308 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 657324003309 active site 657324003310 substrate-binding site [chemical binding]; other site 657324003311 metal-binding site [ion binding] 657324003312 ATP binding site [chemical binding]; other site 657324003313 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 657324003314 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 657324003315 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 657324003316 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 657324003317 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 657324003318 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 657324003319 dimer interface [polypeptide binding]; other site 657324003320 motif 1; other site 657324003321 active site 657324003322 motif 2; other site 657324003323 motif 3; other site 657324003324 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 657324003325 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 657324003326 putative tRNA-binding site [nucleotide binding]; other site 657324003327 B3/4 domain; Region: B3_4; pfam03483 657324003328 tRNA synthetase B5 domain; Region: B5; smart00874 657324003329 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 657324003330 motif 1; other site 657324003331 dimer interface [polypeptide binding]; other site 657324003332 active site 657324003333 motif 2; other site 657324003334 motif 3; other site 657324003335 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 657324003336 PilZ domain; Region: PilZ; pfam07238 657324003337 cell division protein MraZ; Reviewed; Region: PRK00326 657324003338 MraZ protein; Region: MraZ; pfam02381 657324003339 MraZ protein; Region: MraZ; pfam02381 657324003340 MraW methylase family; Region: Methyltransf_5; cl17771 657324003341 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 657324003342 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 657324003343 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 657324003344 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 657324003345 Mg++ binding site [ion binding]; other site 657324003346 putative catalytic motif [active] 657324003347 putative substrate binding site [chemical binding]; other site 657324003348 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 657324003349 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 657324003350 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 657324003351 Ion transport protein; Region: Ion_trans; pfam00520 657324003352 Ion channel; Region: Ion_trans_2; pfam07885 657324003353 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 657324003354 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 657324003355 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 657324003356 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 657324003357 active site 657324003358 ribulose/triose binding site [chemical binding]; other site 657324003359 phosphate binding site [ion binding]; other site 657324003360 substrate (anthranilate) binding pocket [chemical binding]; other site 657324003361 product (indole) binding pocket [chemical binding]; other site 657324003362 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657324003363 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 657324003364 active site 657324003365 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 657324003366 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 657324003367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324003368 catalytic residue [active] 657324003369 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 657324003370 heterodimer interface [polypeptide binding]; other site 657324003371 active site 657324003372 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657324003373 phosphate binding site [ion binding]; other site 657324003374 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 657324003375 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 657324003376 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 657324003377 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 657324003378 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 657324003379 glutamine binding [chemical binding]; other site 657324003380 catalytic triad [active] 657324003381 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657324003382 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657324003383 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 657324003384 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 657324003385 active site 657324003386 Bacterial SH3 domain; Region: SH3_3; cl17532 657324003387 Bacterial SH3 domain; Region: SH3_3; cl17532 657324003388 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 657324003389 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 657324003390 active site 657324003391 dimer interface [polypeptide binding]; other site 657324003392 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 657324003393 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 657324003394 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 657324003395 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 657324003396 active site 657324003397 FMN binding site [chemical binding]; other site 657324003398 substrate binding site [chemical binding]; other site 657324003399 3Fe-4S cluster binding site [ion binding]; other site 657324003400 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 657324003401 domain interface; other site 657324003402 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 657324003403 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 657324003404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657324003405 asparagine synthetase B; Provisional; Region: asnB; PRK09431 657324003406 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 657324003407 dimer interface [polypeptide binding]; other site 657324003408 active site 657324003409 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 657324003410 Ligand Binding Site [chemical binding]; other site 657324003411 Molecular Tunnel; other site 657324003412 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 657324003413 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 657324003414 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 657324003415 ammonium transporter; Region: amt; TIGR00836 657324003416 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 657324003417 Nitrogen regulatory protein P-II; Region: P-II; smart00938 657324003418 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 657324003419 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 657324003420 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 657324003421 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 657324003422 ANTAR domain; Region: ANTAR; pfam03861 657324003423 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 657324003424 putative active site [active] 657324003425 catalytic triad [active] 657324003426 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 657324003427 PA/protease domain interface [polypeptide binding]; other site 657324003428 putative integrin binding motif; other site 657324003429 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 657324003430 catalytic residues [active] 657324003431 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 657324003432 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 657324003433 dockerin binding interface; other site 657324003434 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 657324003435 active site 1 [active] 657324003436 active site 2 [active] 657324003437 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 657324003438 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 657324003439 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324003440 active site 657324003441 HIGH motif; other site 657324003442 nucleotide binding site [chemical binding]; other site 657324003443 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 657324003444 KMSK motif region; other site 657324003445 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 657324003446 tRNA binding surface [nucleotide binding]; other site 657324003447 anticodon binding site; other site 657324003448 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 657324003449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324003450 S-adenosylmethionine binding site [chemical binding]; other site 657324003451 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 657324003452 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657324003453 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657324003454 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657324003455 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657324003456 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 657324003457 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 657324003458 G1 box; other site 657324003459 putative GEF interaction site [polypeptide binding]; other site 657324003460 GTP/Mg2+ binding site [chemical binding]; other site 657324003461 Switch I region; other site 657324003462 G2 box; other site 657324003463 G3 box; other site 657324003464 Switch II region; other site 657324003465 G4 box; other site 657324003466 G5 box; other site 657324003467 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 657324003468 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 657324003469 PAS fold; Region: PAS_3; pfam08447 657324003470 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324003471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324003472 metal binding site [ion binding]; metal-binding site 657324003473 active site 657324003474 I-site; other site 657324003475 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657324003476 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 657324003477 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 657324003478 active site 657324003479 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 657324003480 active site 657324003481 N-terminal domain interface [polypeptide binding]; other site 657324003482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324003483 Walker A/P-loop; other site 657324003484 ATP binding site [chemical binding]; other site 657324003485 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 657324003486 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 657324003487 Q-loop/lid; other site 657324003488 ABC transporter signature motif; other site 657324003489 Walker B; other site 657324003490 D-loop; other site 657324003491 H-loop/switch region; other site 657324003492 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 657324003493 Precorrin-8X methylmutase; Region: CbiC; pfam02570 657324003494 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 657324003495 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 657324003496 active site 657324003497 SAM binding site [chemical binding]; other site 657324003498 homodimer interface [polypeptide binding]; other site 657324003499 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 657324003500 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 657324003501 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 657324003502 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 657324003503 active site 657324003504 SAM binding site [chemical binding]; other site 657324003505 homodimer interface [polypeptide binding]; other site 657324003506 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 657324003507 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 657324003508 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657324003509 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 657324003510 catalytic triad [active] 657324003511 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 657324003512 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 657324003513 putative dimer interface [polypeptide binding]; other site 657324003514 active site pocket [active] 657324003515 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 657324003516 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 657324003517 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657324003518 catalytic core [active] 657324003519 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 657324003520 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 657324003521 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 657324003522 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 657324003523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324003524 FeS/SAM binding site; other site 657324003525 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 657324003526 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657324003527 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 657324003528 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657324003529 active site turn [active] 657324003530 phosphorylation site [posttranslational modification] 657324003531 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 657324003532 HPr interaction site; other site 657324003533 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657324003534 active site 657324003535 phosphorylation site [posttranslational modification] 657324003536 CAT RNA binding domain; Region: CAT_RBD; smart01061 657324003537 PRD domain; Region: PRD; pfam00874 657324003538 PRD domain; Region: PRD; pfam00874 657324003539 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 657324003540 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 657324003541 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 657324003542 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657324003543 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 657324003544 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 657324003545 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 657324003546 FAD binding pocket [chemical binding]; other site 657324003547 FAD binding motif [chemical binding]; other site 657324003548 phosphate binding motif [ion binding]; other site 657324003549 beta-alpha-beta structure motif; other site 657324003550 NAD binding pocket [chemical binding]; other site 657324003551 Iron coordination center [ion binding]; other site 657324003552 putative oxidoreductase; Provisional; Region: PRK12831 657324003553 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657324003554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657324003555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 657324003556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657324003557 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 657324003558 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 657324003559 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 657324003560 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 657324003561 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 657324003562 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 657324003563 Melibiase; Region: Melibiase; pfam02065 657324003564 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324003565 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324003566 dimer interface [polypeptide binding]; other site 657324003567 putative CheW interface [polypeptide binding]; other site 657324003568 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 657324003569 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 657324003570 dimer interface [polypeptide binding]; other site 657324003571 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 657324003572 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 657324003573 Cl- selectivity filter; other site 657324003574 Cl- binding residues [ion binding]; other site 657324003575 pore gating glutamate residue; other site 657324003576 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 657324003577 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 657324003578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324003579 Zn2+ binding site [ion binding]; other site 657324003580 Mg2+ binding site [ion binding]; other site 657324003581 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 657324003582 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 657324003583 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 657324003584 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 657324003585 minor groove reading motif; other site 657324003586 helix-hairpin-helix signature motif; other site 657324003587 active site 657324003588 alanine--tRNA ligase; Region: alaS; TIGR00344 657324003589 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 657324003590 active site 657324003591 motif 3; other site 657324003592 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 657324003593 DHHA1 domain; Region: DHHA1; pfam02272 657324003594 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 657324003595 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 657324003596 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 657324003597 G1 box; other site 657324003598 putative GEF interaction site [polypeptide binding]; other site 657324003599 GTP/Mg2+ binding site [chemical binding]; other site 657324003600 Switch I region; other site 657324003601 G2 box; other site 657324003602 G3 box; other site 657324003603 Switch II region; other site 657324003604 G4 box; other site 657324003605 G5 box; other site 657324003606 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 657324003607 recombinase A; Provisional; Region: recA; PRK09354 657324003608 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 657324003609 hexamer interface [polypeptide binding]; other site 657324003610 Walker A motif; other site 657324003611 ATP binding site [chemical binding]; other site 657324003612 Walker B motif; other site 657324003613 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 657324003614 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 657324003615 dimer interface [polypeptide binding]; other site 657324003616 ADP-ribose binding site [chemical binding]; other site 657324003617 active site 657324003618 nudix motif; other site 657324003619 metal binding site [ion binding]; metal-binding site 657324003620 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324003621 dimer interface [polypeptide binding]; other site 657324003622 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324003623 putative CheW interface [polypeptide binding]; other site 657324003624 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 657324003625 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 657324003626 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 657324003627 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 657324003628 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 657324003629 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 657324003630 shikimate binding site; other site 657324003631 NAD(P) binding site [chemical binding]; other site 657324003632 Bacterial SH3 domain; Region: SH3_3; pfam08239 657324003633 Bacterial SH3 domain; Region: SH3_3; pfam08239 657324003634 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 657324003635 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 657324003636 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 657324003637 nucleotide binding pocket [chemical binding]; other site 657324003638 K-X-D-G motif; other site 657324003639 catalytic site [active] 657324003640 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 657324003641 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 657324003642 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 657324003643 Dimer interface [polypeptide binding]; other site 657324003644 BRCT sequence motif; other site 657324003645 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324003646 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324003647 metal binding site [ion binding]; metal-binding site 657324003648 active site 657324003649 I-site; other site 657324003650 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324003651 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324003652 metal binding site [ion binding]; metal-binding site 657324003653 active site 657324003654 I-site; other site 657324003655 Homoserine O-succinyltransferase; Region: HTS; pfam04204 657324003656 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 657324003657 proposed active site lysine [active] 657324003658 conserved cys residue [active] 657324003659 SpoVG; Region: SpoVG; cl00915 657324003660 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 657324003661 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 657324003662 cofactor binding site; other site 657324003663 DNA binding site [nucleotide binding] 657324003664 substrate interaction site [chemical binding]; other site 657324003665 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 657324003666 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 657324003667 putative active site [active] 657324003668 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 657324003669 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 657324003670 ArsC family; Region: ArsC; pfam03960 657324003671 catalytic residue [active] 657324003672 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 657324003673 Yqey-like protein; Region: YqeY; cl17540 657324003674 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 657324003675 homodimer interface [polypeptide binding]; other site 657324003676 chemical substrate binding site [chemical binding]; other site 657324003677 oligomer interface [polypeptide binding]; other site 657324003678 metal binding site [ion binding]; metal-binding site 657324003679 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 657324003680 active site 657324003681 8-oxo-dGMP binding site [chemical binding]; other site 657324003682 nudix motif; other site 657324003683 metal binding site [ion binding]; metal-binding site 657324003684 Acylphosphatase; Region: Acylphosphatase; pfam00708 657324003685 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 657324003686 active site 657324003687 catalytic residues [active] 657324003688 metal binding site [ion binding]; metal-binding site 657324003689 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657324003690 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657324003691 active site 657324003692 metal binding site [ion binding]; metal-binding site 657324003693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324003694 Response regulator receiver domain; Region: Response_reg; pfam00072 657324003695 active site 657324003696 phosphorylation site [posttranslational modification] 657324003697 intermolecular recognition site; other site 657324003698 dimerization interface [polypeptide binding]; other site 657324003699 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657324003700 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324003701 Zn2+ binding site [ion binding]; other site 657324003702 Mg2+ binding site [ion binding]; other site 657324003703 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324003704 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657324003705 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 657324003706 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 657324003707 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 657324003708 HD domain; Region: HD_3; pfam13023 657324003709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657324003710 NAD(P) binding site [chemical binding]; other site 657324003711 classical (c) SDRs; Region: SDR_c; cd05233 657324003712 active site 657324003713 Survival protein SurE; Region: SurE; cl00448 657324003714 Asp23 family; Region: Asp23; pfam03780 657324003715 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 657324003716 putative RNA binding site [nucleotide binding]; other site 657324003717 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 657324003718 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 657324003719 generic binding surface II; other site 657324003720 generic binding surface I; other site 657324003721 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 657324003722 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 657324003723 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 657324003724 substrate binding pocket [chemical binding]; other site 657324003725 chain length determination region; other site 657324003726 substrate-Mg2+ binding site; other site 657324003727 catalytic residues [active] 657324003728 aspartate-rich region 1; other site 657324003729 active site lid residues [active] 657324003730 aspartate-rich region 2; other site 657324003731 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 657324003732 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 657324003733 TPP-binding site; other site 657324003734 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 657324003735 PYR/PP interface [polypeptide binding]; other site 657324003736 dimer interface [polypeptide binding]; other site 657324003737 TPP binding site [chemical binding]; other site 657324003738 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 657324003739 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 657324003740 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657324003741 RNA binding surface [nucleotide binding]; other site 657324003742 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 657324003743 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 657324003744 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 657324003745 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 657324003746 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 657324003747 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 657324003748 Walker A/P-loop; other site 657324003749 ATP binding site [chemical binding]; other site 657324003750 Q-loop/lid; other site 657324003751 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 657324003752 Q-loop/lid; other site 657324003753 ABC transporter signature motif; other site 657324003754 Walker B; other site 657324003755 D-loop; other site 657324003756 H-loop/switch region; other site 657324003757 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 657324003758 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 657324003759 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 657324003760 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 657324003761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324003762 dimer interface [polypeptide binding]; other site 657324003763 conserved gate region; other site 657324003764 putative PBP binding loops; other site 657324003765 ABC-ATPase subunit interface; other site 657324003766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324003767 putative PBP binding loops; other site 657324003768 dimer interface [polypeptide binding]; other site 657324003769 ABC-ATPase subunit interface; other site 657324003770 argininosuccinate lyase; Provisional; Region: PRK00855 657324003771 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 657324003772 active sites [active] 657324003773 tetramer interface [polypeptide binding]; other site 657324003774 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 657324003775 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 657324003776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657324003777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657324003778 dimer interface [polypeptide binding]; other site 657324003779 phosphorylation site [posttranslational modification] 657324003780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324003781 ATP binding site [chemical binding]; other site 657324003782 Mg2+ binding site [ion binding]; other site 657324003783 G-X-G motif; other site 657324003784 Response regulator receiver domain; Region: Response_reg; pfam00072 657324003785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324003786 active site 657324003787 phosphorylation site [posttranslational modification] 657324003788 intermolecular recognition site; other site 657324003789 dimerization interface [polypeptide binding]; other site 657324003790 Hpt domain; Region: Hpt; pfam01627 657324003791 Response regulator receiver domain; Region: Response_reg; pfam00072 657324003792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324003793 active site 657324003794 phosphorylation site [posttranslational modification] 657324003795 intermolecular recognition site; other site 657324003796 dimerization interface [polypeptide binding]; other site 657324003797 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 657324003798 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 657324003799 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 657324003800 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 657324003801 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 657324003802 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 657324003803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324003804 Zn2+ binding site [ion binding]; other site 657324003805 Mg2+ binding site [ion binding]; other site 657324003806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657324003807 dimer interface [polypeptide binding]; other site 657324003808 phosphorylation site [posttranslational modification] 657324003809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324003810 Response regulator receiver domain; Region: Response_reg; pfam00072 657324003811 active site 657324003812 phosphorylation site [posttranslational modification] 657324003813 intermolecular recognition site; other site 657324003814 dimerization interface [polypeptide binding]; other site 657324003815 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324003816 Zn2+ binding site [ion binding]; other site 657324003817 Mg2+ binding site [ion binding]; other site 657324003818 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 657324003819 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 657324003820 GGGtGRT protein; Region: GGGtGRT; pfam14057 657324003821 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 657324003822 active site 657324003823 catalytic residues [active] 657324003824 metal binding site [ion binding]; metal-binding site 657324003825 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 657324003826 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 657324003827 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 657324003828 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 657324003829 putative valine binding site [chemical binding]; other site 657324003830 dimer interface [polypeptide binding]; other site 657324003831 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 657324003832 ketol-acid reductoisomerase; Provisional; Region: PRK05479 657324003833 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 657324003834 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 657324003835 AzlC protein; Region: AzlC; pfam03591 657324003836 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 657324003837 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 657324003838 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 657324003839 putative ligand binding site [chemical binding]; other site 657324003840 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 657324003841 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 657324003842 Walker A/P-loop; other site 657324003843 ATP binding site [chemical binding]; other site 657324003844 Q-loop/lid; other site 657324003845 ABC transporter signature motif; other site 657324003846 Walker B; other site 657324003847 D-loop; other site 657324003848 H-loop/switch region; other site 657324003849 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 657324003850 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324003851 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 657324003852 Response regulator receiver domain; Region: Response_reg; pfam00072 657324003853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324003854 active site 657324003855 phosphorylation site [posttranslational modification] 657324003856 intermolecular recognition site; other site 657324003857 dimerization interface [polypeptide binding]; other site 657324003858 Cache domain; Region: Cache_1; pfam02743 657324003859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 657324003860 Histidine kinase; Region: His_kinase; pfam06580 657324003861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324003862 ATP binding site [chemical binding]; other site 657324003863 Mg2+ binding site [ion binding]; other site 657324003864 G-X-G motif; other site 657324003865 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 657324003866 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657324003867 ligand binding site [chemical binding]; other site 657324003868 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324003869 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324003870 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 657324003871 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324003872 active site 657324003873 HIGH motif; other site 657324003874 nucleotide binding site [chemical binding]; other site 657324003875 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324003876 active site 657324003877 KMSKS motif; other site 657324003878 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 657324003879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 657324003880 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 657324003881 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 657324003882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324003883 S-adenosylmethionine binding site [chemical binding]; other site 657324003884 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 657324003885 RNA methyltransferase, RsmE family; Region: TIGR00046 657324003886 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657324003887 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 657324003888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657324003889 catalytic residue [active] 657324003890 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 657324003891 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 657324003892 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 657324003893 Ligand Binding Site [chemical binding]; other site 657324003894 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 657324003895 regulatory protein interface [polypeptide binding]; other site 657324003896 regulatory phosphorylation site [posttranslational modification]; other site 657324003897 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 657324003898 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 657324003899 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 657324003900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324003901 FeS/SAM binding site; other site 657324003902 hypothetical protein; Provisional; Region: PRK05473 657324003903 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 657324003904 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 657324003905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324003906 S-adenosylmethionine binding site [chemical binding]; other site 657324003907 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 657324003908 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657324003909 Peptidase family U32; Region: Peptidase_U32; pfam01136 657324003910 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 657324003911 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 657324003912 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 657324003913 Tetramer interface [polypeptide binding]; other site 657324003914 active site 657324003915 FMN-binding site [chemical binding]; other site 657324003916 Preprotein translocase subunit; Region: YajC; pfam02699 657324003917 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 657324003918 Preprotein translocase SecG subunit; Region: SecG; pfam03840 657324003919 ribonuclease R; Region: RNase_R; TIGR02063 657324003920 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 657324003921 RNB domain; Region: RNB; pfam00773 657324003922 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 657324003923 RNA binding site [nucleotide binding]; other site 657324003924 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 657324003925 SmpB-tmRNA interface; other site 657324003926 Maf-like protein; Reviewed; Region: PRK00078 657324003927 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 657324003928 active site 657324003929 dimer interface [polypeptide binding]; other site 657324003930 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 657324003931 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 657324003932 phosphoglycolate phosphatase; Provisional; Region: PRK13222 657324003933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324003934 motif II; other site 657324003935 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 657324003936 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 657324003937 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 657324003938 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 657324003939 active site 657324003940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657324003941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324003942 homodimer interface [polypeptide binding]; other site 657324003943 catalytic residue [active] 657324003944 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 657324003945 putative catalytic site [active] 657324003946 putative metal binding site [ion binding]; other site 657324003947 putative phosphate binding site [ion binding]; other site 657324003948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657324003949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324003950 active site 657324003951 phosphorylation site [posttranslational modification] 657324003952 intermolecular recognition site; other site 657324003953 dimerization interface [polypeptide binding]; other site 657324003954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657324003955 DNA binding site [nucleotide binding] 657324003956 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 657324003957 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 657324003958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324003959 active site 657324003960 phosphorylation site [posttranslational modification] 657324003961 intermolecular recognition site; other site 657324003962 dimerization interface [polypeptide binding]; other site 657324003963 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 657324003964 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 657324003965 putative active site [active] 657324003966 oxyanion strand; other site 657324003967 catalytic triad [active] 657324003968 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 657324003969 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 657324003970 substrate binding site [chemical binding]; other site 657324003971 glutamase interaction surface [polypeptide binding]; other site 657324003972 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 657324003973 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 657324003974 Sm and related proteins; Region: Sm_like; cl00259 657324003975 ribosome maturation protein RimP; Reviewed; Region: PRK00092 657324003976 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 657324003977 NusA N-terminal domain; Region: NusA_N; pfam08529 657324003978 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 657324003979 RNA binding site [nucleotide binding]; other site 657324003980 homodimer interface [polypeptide binding]; other site 657324003981 NusA-like KH domain; Region: KH_5; pfam13184 657324003982 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 657324003983 G-X-X-G motif; other site 657324003984 Protein of unknown function (DUF448); Region: DUF448; pfam04296 657324003985 putative RNA binding cleft [nucleotide binding]; other site 657324003986 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 657324003987 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 657324003988 translation initiation factor IF-2; Region: IF-2; TIGR00487 657324003989 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 657324003990 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 657324003991 G1 box; other site 657324003992 putative GEF interaction site [polypeptide binding]; other site 657324003993 GTP/Mg2+ binding site [chemical binding]; other site 657324003994 Switch I region; other site 657324003995 G2 box; other site 657324003996 G3 box; other site 657324003997 Switch II region; other site 657324003998 G4 box; other site 657324003999 G5 box; other site 657324004000 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 657324004001 Translation-initiation factor 2; Region: IF-2; pfam11987 657324004002 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 657324004003 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 657324004004 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 657324004005 DHH family; Region: DHH; pfam01368 657324004006 DHHA1 domain; Region: DHHA1; pfam02272 657324004007 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 657324004008 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 657324004009 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 657324004010 active site 657324004011 Riboflavin kinase; Region: Flavokinase; pfam01687 657324004012 Bacterial SH3 domain; Region: SH3_3; pfam08239 657324004013 Bacterial SH3 domain; Region: SH3_3; pfam08239 657324004014 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 657324004015 NlpC/P60 family; Region: NLPC_P60; pfam00877 657324004016 hypothetical protein; Provisional; Region: PRK05590 657324004017 SEC-C motif; Region: SEC-C; pfam02810 657324004018 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 657324004019 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 657324004020 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 657324004021 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 657324004022 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 657324004023 hinge; other site 657324004024 active site 657324004025 prephenate dehydrogenase; Validated; Region: PRK08507 657324004026 prephenate dehydrogenase; Validated; Region: PRK06545 657324004027 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 657324004028 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 657324004029 elongation factor G; Reviewed; Region: PRK12740 657324004030 G1 box; other site 657324004031 putative GEF interaction site [polypeptide binding]; other site 657324004032 GTP/Mg2+ binding site [chemical binding]; other site 657324004033 Switch I region; other site 657324004034 G2 box; other site 657324004035 G3 box; other site 657324004036 Switch II region; other site 657324004037 G4 box; other site 657324004038 G5 box; other site 657324004039 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 657324004040 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 657324004041 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 657324004042 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 657324004043 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 657324004044 HIGH motif; other site 657324004045 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 657324004046 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 657324004047 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324004048 active site 657324004049 KMSKS motif; other site 657324004050 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 657324004051 tRNA binding surface [nucleotide binding]; other site 657324004052 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 657324004053 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 657324004054 isocitrate dehydrogenase; Validated; Region: PRK08299 657324004055 ScpA/B protein; Region: ScpA_ScpB; cl00598 657324004056 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 657324004057 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 657324004058 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 657324004059 carboxyltransferase (CT) interaction site; other site 657324004060 biotinylation site [posttranslational modification]; other site 657324004061 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 657324004062 oxaloacetate decarboxylase; Provisional; Region: PRK12331 657324004063 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 657324004064 active site 657324004065 catalytic residues [active] 657324004066 metal binding site [ion binding]; metal-binding site 657324004067 homodimer binding site [polypeptide binding]; other site 657324004068 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 657324004069 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657324004070 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657324004071 putative active site [active] 657324004072 cytidylate kinase; Provisional; Region: cmk; PRK00023 657324004073 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 657324004074 CMP-binding site; other site 657324004075 The sites determining sugar specificity; other site 657324004076 LytB protein; Region: LYTB; cl00507 657324004077 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 657324004078 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 657324004079 RNA binding site [nucleotide binding]; other site 657324004080 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 657324004081 RNA binding site [nucleotide binding]; other site 657324004082 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 657324004083 RNA binding site [nucleotide binding]; other site 657324004084 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 657324004085 RNA binding site [nucleotide binding]; other site 657324004086 domain interface; other site 657324004087 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 657324004088 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 657324004089 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 657324004090 RNase_H superfamily; Region: RNase_H_2; pfam13482 657324004091 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 657324004092 SLBB domain; Region: SLBB; pfam10531 657324004093 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657324004094 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 657324004095 FMN-binding domain; Region: FMN_bind; cl01081 657324004096 electron transport complex RsxE subunit; Provisional; Region: PRK12405 657324004097 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA [Energy production and conversion]; Region: RnfA; COG4657 657324004098 ferredoxin; Validated; Region: PRK07118 657324004099 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657324004100 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657324004101 gamma-glutamyl kinase; Provisional; Region: PRK05429 657324004102 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 657324004103 nucleotide binding site [chemical binding]; other site 657324004104 homotetrameric interface [polypeptide binding]; other site 657324004105 putative phosphate binding site [ion binding]; other site 657324004106 putative allosteric binding site; other site 657324004107 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 657324004108 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 657324004109 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 657324004110 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 657324004111 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 657324004112 NAD(P) binding site [chemical binding]; other site 657324004113 catalytic residues [active] 657324004114 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 657324004115 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 657324004116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324004117 FeS/SAM binding site; other site 657324004118 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 657324004119 RuvA N terminal domain; Region: RuvA_N; pfam01330 657324004120 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 657324004121 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 657324004122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324004123 Walker A motif; other site 657324004124 ATP binding site [chemical binding]; other site 657324004125 Walker B motif; other site 657324004126 arginine finger; other site 657324004127 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 657324004128 Cell division protein ZapA; Region: ZapA; pfam05164 657324004129 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 657324004130 Peptidase family U32; Region: Peptidase_U32; pfam01136 657324004131 Collagenase; Region: DUF3656; pfam12392 657324004132 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 657324004133 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 657324004134 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 657324004135 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 657324004136 Asp23 family; Region: Asp23; pfam03780 657324004137 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 657324004138 DAK2 domain; Region: Dak2; pfam02734 657324004139 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 657324004140 ssDNA binding site; other site 657324004141 generic binding surface II; other site 657324004142 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 657324004143 hypothetical protein; Provisional; Region: PRK11820 657324004144 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 657324004145 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 657324004146 Domain of unknown function (DUF370); Region: DUF370; cl00898 657324004147 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 657324004148 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 657324004149 catalytic site [active] 657324004150 G-X2-G-X-G-K; other site 657324004151 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657324004152 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 657324004153 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 657324004154 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 657324004155 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324004156 FeS/SAM binding site; other site 657324004157 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 657324004158 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 657324004159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 657324004160 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 657324004161 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 657324004162 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 657324004163 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 657324004164 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657324004165 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657324004166 RNA binding surface [nucleotide binding]; other site 657324004167 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657324004168 active site 657324004169 Recombination protein U; Region: RecU; pfam03838 657324004170 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 657324004171 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 657324004172 dimer interface [polypeptide binding]; other site 657324004173 motif 1; other site 657324004174 active site 657324004175 motif 2; other site 657324004176 motif 3; other site 657324004177 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 657324004178 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 657324004179 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 657324004180 histidinol dehydrogenase; Region: hisD; TIGR00069 657324004181 NAD binding site [chemical binding]; other site 657324004182 dimerization interface [polypeptide binding]; other site 657324004183 zinc binding site [ion binding]; other site 657324004184 catalytic residues [active] 657324004185 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 657324004186 putative active site pocket [active] 657324004187 4-fold oligomerization interface [polypeptide binding]; other site 657324004188 metal binding residues [ion binding]; metal-binding site 657324004189 3-fold/trimer interface [polypeptide binding]; other site 657324004190 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657324004191 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 657324004192 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 657324004193 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 657324004194 metal binding site [ion binding]; metal-binding site 657324004195 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 657324004196 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 657324004197 B12 binding site [chemical binding]; other site 657324004198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324004199 FeS/SAM binding site; other site 657324004200 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 657324004201 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 657324004202 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 657324004203 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 657324004204 Staphylococcal nuclease homologues; Region: SNc; smart00318 657324004205 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 657324004206 Catalytic site; other site 657324004207 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 657324004208 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 657324004209 Protein of unknown function (DUF464); Region: DUF464; pfam04327 657324004210 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 657324004211 GTPase CgtA; Reviewed; Region: obgE; PRK12297 657324004212 GTP1/OBG; Region: GTP1_OBG; pfam01018 657324004213 Obg GTPase; Region: Obg; cd01898 657324004214 G1 box; other site 657324004215 GTP/Mg2+ binding site [chemical binding]; other site 657324004216 Switch I region; other site 657324004217 G2 box; other site 657324004218 G3 box; other site 657324004219 Switch II region; other site 657324004220 G4 box; other site 657324004221 G5 box; other site 657324004222 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 657324004223 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 657324004224 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 657324004225 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 657324004226 active site 657324004227 (T/H)XGH motif; other site 657324004228 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324004229 Zn2+ binding site [ion binding]; other site 657324004230 Mg2+ binding site [ion binding]; other site 657324004231 Oligomerisation domain; Region: Oligomerisation; pfam02410 657324004232 LexA repressor; Validated; Region: PRK00215 657324004233 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 657324004234 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 657324004235 Catalytic site [active] 657324004236 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657324004237 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 657324004238 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 657324004239 putative acyl-acceptor binding pocket; other site 657324004240 Y-family of DNA polymerases; Region: PolY; cl12025 657324004241 DNA polymerase IV; Reviewed; Region: PRK03103 657324004242 DNA binding site [nucleotide binding] 657324004243 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 657324004244 active site 657324004245 catalytic residues [active] 657324004246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 657324004247 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 657324004248 Chromate transporter; Region: Chromate_transp; pfam02417 657324004249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324004250 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 657324004251 Coenzyme A binding pocket [chemical binding]; other site 657324004252 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 657324004253 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657324004254 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 657324004255 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 657324004256 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 657324004257 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657324004258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324004259 active site 657324004260 motif I; other site 657324004261 motif II; other site 657324004262 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657324004263 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 657324004264 nudix motif; other site 657324004265 Predicted membrane protein [Function unknown]; Region: COG2510 657324004266 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657324004267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324004268 Cupin domain; Region: Cupin_2; cl17218 657324004269 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 657324004270 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 657324004271 Walker A/P-loop; other site 657324004272 ATP binding site [chemical binding]; other site 657324004273 Q-loop/lid; other site 657324004274 ABC transporter signature motif; other site 657324004275 Walker B; other site 657324004276 D-loop; other site 657324004277 H-loop/switch region; other site 657324004278 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 657324004279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324004280 H-loop/switch region; other site 657324004281 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324004282 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 657324004283 TM-ABC transporter signature motif; other site 657324004284 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cd01391 657324004285 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657324004286 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324004287 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 657324004288 TM-ABC transporter signature motif; other site 657324004289 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 657324004290 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 657324004291 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 657324004292 beta-phosphoglucomutase; Region: bPGM; TIGR01990 657324004293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324004294 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 657324004295 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 657324004296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324004297 motif II; other site 657324004298 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657324004299 Predicted transcriptional regulator [Transcription]; Region: COG1959 657324004300 Transcriptional regulator; Region: Rrf2; pfam02082 657324004301 Cupin domain; Region: Cupin_2; pfam07883 657324004302 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 657324004303 Radical SAM superfamily; Region: Radical_SAM; pfam04055 657324004304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324004305 FeS/SAM binding site; other site 657324004306 Helix-turn-helix domain; Region: HTH_38; pfam13936 657324004307 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 657324004308 Integrase core domain; Region: rve; pfam00665 657324004309 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657324004310 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657324004311 RNA binding surface [nucleotide binding]; other site 657324004312 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657324004313 active site 657324004314 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 657324004315 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 657324004316 active site 657324004317 dimer interface [polypeptide binding]; other site 657324004318 metal binding site [ion binding]; metal-binding site 657324004319 Protein of unknown function (DUF552); Region: DUF552; pfam04472 657324004320 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 657324004321 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657324004322 HlyD family secretion protein; Region: HlyD_2; pfam12700 657324004323 putative membrane fusion protein; Region: TIGR02828 657324004324 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 657324004325 active site 657324004326 dimer interfaces [polypeptide binding]; other site 657324004327 catalytic residues [active] 657324004328 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 657324004329 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 657324004330 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 657324004331 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 657324004332 rod shape-determining protein MreC; Provisional; Region: PRK13922 657324004333 rod shape-determining protein MreC; Region: MreC; pfam04085 657324004334 MreB and similar proteins; Region: MreB_like; cd10225 657324004335 rod shape-determining protein MreB; Provisional; Region: PRK13927 657324004336 nucleotide binding site [chemical binding]; other site 657324004337 Mg binding site [ion binding]; other site 657324004338 putative protofilament interaction site [polypeptide binding]; other site 657324004339 RodZ interaction site [polypeptide binding]; other site 657324004340 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 657324004341 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 657324004342 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 657324004343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324004344 ATP binding site [chemical binding]; other site 657324004345 Mg2+ binding site [ion binding]; other site 657324004346 G-X-G motif; other site 657324004347 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 657324004348 ATP binding site [chemical binding]; other site 657324004349 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 657324004350 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 657324004351 MutS domain I; Region: MutS_I; pfam01624 657324004352 MutS domain II; Region: MutS_II; pfam05188 657324004353 MutS domain III; Region: MutS_III; pfam05192 657324004354 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 657324004355 Walker A/P-loop; other site 657324004356 ATP binding site [chemical binding]; other site 657324004357 Q-loop/lid; other site 657324004358 ABC transporter signature motif; other site 657324004359 Walker B; other site 657324004360 D-loop; other site 657324004361 H-loop/switch region; other site 657324004362 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 657324004363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657324004364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657324004365 flavoprotein, HI0933 family; Region: TIGR00275 657324004366 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657324004367 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657324004368 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657324004369 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 657324004370 metal-binding heat shock protein; Provisional; Region: PRK00016 657324004371 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 657324004372 PhoH-like protein; Region: PhoH; pfam02562 657324004373 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 657324004374 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 657324004375 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 657324004376 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 657324004377 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 657324004378 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 657324004379 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 657324004380 Double zinc ribbon; Region: DZR; pfam12773 657324004381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657324004382 binding surface 657324004383 TPR repeat; Region: TPR_11; pfam13414 657324004384 TPR motif; other site 657324004385 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 657324004386 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 657324004387 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 657324004388 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 657324004389 Potassium binding sites [ion binding]; other site 657324004390 Cesium cation binding sites [ion binding]; other site 657324004391 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 657324004392 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657324004393 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 657324004394 glycogen synthase; Provisional; Region: glgA; PRK00654 657324004395 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 657324004396 ADP-binding pocket [chemical binding]; other site 657324004397 homodimer interface [polypeptide binding]; other site 657324004398 Transcriptional regulator; Region: Transcrip_reg; cl00361 657324004399 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 657324004400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324004401 Walker A/P-loop; other site 657324004402 ATP binding site [chemical binding]; other site 657324004403 Q-loop/lid; other site 657324004404 ABC transporter signature motif; other site 657324004405 Walker B; other site 657324004406 D-loop; other site 657324004407 H-loop/switch region; other site 657324004408 ABC transporter; Region: ABC_tran_2; pfam12848 657324004409 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657324004410 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 657324004411 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 657324004412 RNase E interface [polypeptide binding]; other site 657324004413 trimer interface [polypeptide binding]; other site 657324004414 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 657324004415 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 657324004416 RNase E interface [polypeptide binding]; other site 657324004417 trimer interface [polypeptide binding]; other site 657324004418 active site 657324004419 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 657324004420 putative nucleic acid binding region [nucleotide binding]; other site 657324004421 G-X-X-G motif; other site 657324004422 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 657324004423 RNA binding site [nucleotide binding]; other site 657324004424 domain interface; other site 657324004425 S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic...; Region: S15_NS1_EPRS_RNA-bind; cl00349 657324004426 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 657324004427 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 657324004428 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 657324004429 GDP-binding site [chemical binding]; other site 657324004430 ACT binding site; other site 657324004431 IMP binding site; other site 657324004432 EDD domain protein, DegV family; Region: DegV; TIGR00762 657324004433 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 657324004434 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 657324004435 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 657324004436 ring oligomerisation interface [polypeptide binding]; other site 657324004437 ATP/Mg binding site [chemical binding]; other site 657324004438 stacking interactions; other site 657324004439 hinge regions; other site 657324004440 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 657324004441 oligomerisation interface [polypeptide binding]; other site 657324004442 mobile loop; other site 657324004443 roof hairpin; other site 657324004444 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 657324004445 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 657324004446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324004447 motif II; other site 657324004448 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 657324004449 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 657324004450 CAP-like domain; other site 657324004451 active site 657324004452 primary dimer interface [polypeptide binding]; other site 657324004453 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657324004454 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 657324004455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324004456 ATP binding site [chemical binding]; other site 657324004457 Mg2+ binding site [ion binding]; other site 657324004458 G-X-G motif; other site 657324004459 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 657324004460 anchoring element; other site 657324004461 dimer interface [polypeptide binding]; other site 657324004462 ATP binding site [chemical binding]; other site 657324004463 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 657324004464 active site 657324004465 putative metal-binding site [ion binding]; other site 657324004466 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 657324004467 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 657324004468 trimer interface [polypeptide binding]; other site 657324004469 active site 657324004470 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 657324004471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324004472 FeS/SAM binding site; other site 657324004473 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 657324004474 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 657324004475 Predicted transcriptional regulators [Transcription]; Region: COG1733 657324004476 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 657324004477 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 657324004478 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 657324004479 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 657324004480 trimer interface [polypeptide binding]; other site 657324004481 putative metal binding site [ion binding]; other site 657324004482 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 657324004483 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 657324004484 substrate binding [chemical binding]; other site 657324004485 active site 657324004486 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 657324004487 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 657324004488 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657324004489 active site turn [active] 657324004490 phosphorylation site [posttranslational modification] 657324004491 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657324004492 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 657324004493 HPr interaction site; other site 657324004494 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657324004495 active site 657324004496 phosphorylation site [posttranslational modification] 657324004497 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324004498 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324004499 DNA binding site [nucleotide binding] 657324004500 domain linker motif; other site 657324004501 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324004502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324004503 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324004504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657324004505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324004506 S-adenosylmethionine binding site [chemical binding]; other site 657324004507 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 657324004508 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 657324004509 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 657324004510 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 657324004511 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 657324004512 GTP-binding protein Der; Reviewed; Region: PRK00093 657324004513 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 657324004514 G1 box; other site 657324004515 GTP/Mg2+ binding site [chemical binding]; other site 657324004516 Switch I region; other site 657324004517 G2 box; other site 657324004518 Switch II region; other site 657324004519 G3 box; other site 657324004520 G4 box; other site 657324004521 G5 box; other site 657324004522 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 657324004523 G1 box; other site 657324004524 GTP/Mg2+ binding site [chemical binding]; other site 657324004525 Switch I region; other site 657324004526 G2 box; other site 657324004527 G3 box; other site 657324004528 Switch II region; other site 657324004529 G4 box; other site 657324004530 G5 box; other site 657324004531 Protein of unknown function (DUF512); Region: DUF512; pfam04459 657324004532 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 657324004533 hypothetical protein; Reviewed; Region: PRK12497 657324004534 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 657324004535 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 657324004536 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 657324004537 RNA/DNA hybrid binding site [nucleotide binding]; other site 657324004538 active site 657324004539 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 657324004540 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 657324004541 Catalytic site [active] 657324004542 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 657324004543 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 657324004544 GTP/Mg2+ binding site [chemical binding]; other site 657324004545 G4 box; other site 657324004546 G5 box; other site 657324004547 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 657324004548 G1 box; other site 657324004549 G1 box; other site 657324004550 GTP/Mg2+ binding site [chemical binding]; other site 657324004551 Switch I region; other site 657324004552 G2 box; other site 657324004553 G2 box; other site 657324004554 G3 box; other site 657324004555 G3 box; other site 657324004556 Switch II region; other site 657324004557 Switch II region; other site 657324004558 G4 box; other site 657324004559 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 657324004560 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 657324004561 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 657324004562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657324004563 Walker A/P-loop; other site 657324004564 ATP binding site [chemical binding]; other site 657324004565 Q-loop/lid; other site 657324004566 ABC transporter signature motif; other site 657324004567 Walker B; other site 657324004568 D-loop; other site 657324004569 H-loop/switch region; other site 657324004570 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 657324004571 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657324004572 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 657324004573 Walker A/P-loop; other site 657324004574 ATP binding site [chemical binding]; other site 657324004575 Q-loop/lid; other site 657324004576 ABC transporter signature motif; other site 657324004577 Walker B; other site 657324004578 D-loop; other site 657324004579 H-loop/switch region; other site 657324004580 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 657324004581 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 657324004582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324004583 dimer interface [polypeptide binding]; other site 657324004584 conserved gate region; other site 657324004585 putative PBP binding loops; other site 657324004586 ABC-ATPase subunit interface; other site 657324004587 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 657324004588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324004589 dimer interface [polypeptide binding]; other site 657324004590 conserved gate region; other site 657324004591 putative PBP binding loops; other site 657324004592 ABC-ATPase subunit interface; other site 657324004593 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 657324004594 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 657324004595 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 657324004596 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 657324004597 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 657324004598 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 657324004599 signal recognition particle protein; Provisional; Region: PRK10867 657324004600 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 657324004601 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 657324004602 P loop; other site 657324004603 GTP binding site [chemical binding]; other site 657324004604 Signal peptide binding domain; Region: SRP_SPB; pfam02978 657324004605 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 657324004606 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657324004607 DNA binding residues [nucleotide binding] 657324004608 threonine dehydratase; Provisional; Region: PRK08198 657324004609 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 657324004610 tetramer interface [polypeptide binding]; other site 657324004611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324004612 catalytic residue [active] 657324004613 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 657324004614 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 657324004615 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 657324004616 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 657324004617 P loop; other site 657324004618 GTP binding site [chemical binding]; other site 657324004619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324004620 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 657324004621 AAA domain; Region: AAA_23; pfam13476 657324004622 Walker A/P-loop; other site 657324004623 ATP binding site [chemical binding]; other site 657324004624 Q-loop/lid; other site 657324004625 acyl carrier protein; Provisional; Region: acpP; PRK00982 657324004626 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 657324004627 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 657324004628 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 657324004629 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 657324004630 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 657324004631 propionate/acetate kinase; Provisional; Region: PRK12379 657324004632 hypothetical protein; Provisional; Region: PRK13670 657324004633 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 657324004634 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 657324004635 UDP-glucose 4-epimerase; Region: PLN02240 657324004636 NAD binding site [chemical binding]; other site 657324004637 homodimer interface [polypeptide binding]; other site 657324004638 active site 657324004639 substrate binding site [chemical binding]; other site 657324004640 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 657324004641 23S rRNA binding site [nucleotide binding]; other site 657324004642 L21 binding site [polypeptide binding]; other site 657324004643 L13 binding site [polypeptide binding]; other site 657324004644 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 657324004645 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 657324004646 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 657324004647 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 657324004648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324004649 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657324004650 active site 657324004651 motif I; other site 657324004652 motif II; other site 657324004653 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 657324004654 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 657324004655 polyphosphate kinase; Provisional; Region: PRK05443 657324004656 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 657324004657 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 657324004658 putative domain interface [polypeptide binding]; other site 657324004659 putative active site [active] 657324004660 catalytic site [active] 657324004661 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 657324004662 catalytic site [active] 657324004663 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 657324004664 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 657324004665 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 657324004666 hypothetical protein; Provisional; Region: PRK07248 657324004667 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 657324004668 Prephenate dehydratase; Region: PDT; pfam00800 657324004669 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 657324004670 putative L-Phe binding site [chemical binding]; other site 657324004671 DNA polymerase III PolC; Validated; Region: polC; PRK00448 657324004672 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 657324004673 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 657324004674 generic binding surface II; other site 657324004675 generic binding surface I; other site 657324004676 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 657324004677 active site 657324004678 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 657324004679 active site 657324004680 catalytic site [active] 657324004681 substrate binding site [chemical binding]; other site 657324004682 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 657324004683 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 657324004684 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 657324004685 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 657324004686 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 657324004687 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 657324004688 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 657324004689 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 657324004690 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 657324004691 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 657324004692 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 657324004693 catalytic residue [active] 657324004694 putative FPP diphosphate binding site; other site 657324004695 ribosome recycling factor; Reviewed; Region: frr; PRK00083 657324004696 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 657324004697 hinge region; other site 657324004698 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 657324004699 putative nucleotide binding site [chemical binding]; other site 657324004700 uridine monophosphate binding site [chemical binding]; other site 657324004701 homohexameric interface [polypeptide binding]; other site 657324004702 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 657324004703 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 657324004704 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 657324004705 NodB motif; other site 657324004706 active site 657324004707 catalytic site [active] 657324004708 Zn binding site [ion binding]; other site 657324004709 elongation factor Ts; Provisional; Region: tsf; PRK09377 657324004710 UBA/TS-N domain; Region: UBA; pfam00627 657324004711 Elongation factor TS; Region: EF_TS; pfam00889 657324004712 Elongation factor TS; Region: EF_TS; pfam00889 657324004713 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 657324004714 rRNA interaction site [nucleotide binding]; other site 657324004715 S8 interaction site; other site 657324004716 putative laminin-1 binding site; other site 657324004717 YceG-like family; Region: YceG; pfam02618 657324004718 phosphodiesterase; Provisional; Region: PRK12704 657324004719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657324004720 DNA binding residues [nucleotide binding] 657324004721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657324004722 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 657324004723 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 657324004724 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 657324004725 CheC-like family; Region: CheC; pfam04509 657324004726 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 657324004727 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 657324004728 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 657324004729 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 657324004730 putative binding surface; other site 657324004731 active site 657324004732 P2 response regulator binding domain; Region: P2; pfam07194 657324004733 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 657324004734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324004735 ATP binding site [chemical binding]; other site 657324004736 Mg2+ binding site [ion binding]; other site 657324004737 G-X-G motif; other site 657324004738 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 657324004739 CheB methylesterase; Region: CheB_methylest; pfam01339 657324004740 Response regulator receiver domain; Region: Response_reg; pfam00072 657324004741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324004742 active site 657324004743 phosphorylation site [posttranslational modification] 657324004744 intermolecular recognition site; other site 657324004745 dimerization interface [polypeptide binding]; other site 657324004746 Flagellar protein YcgR; Region: YcgR_2; pfam12945 657324004747 PilZ domain; Region: PilZ; pfam07238 657324004748 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 657324004749 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 657324004750 P-loop; other site 657324004751 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 657324004752 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657324004753 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 657324004754 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 657324004755 FHIPEP family; Region: FHIPEP; pfam00771 657324004756 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 657324004757 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 657324004758 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 657324004759 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 657324004760 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 657324004761 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 657324004762 Response regulator receiver domain; Region: Response_reg; pfam00072 657324004763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324004764 active site 657324004765 phosphorylation site [posttranslational modification] 657324004766 intermolecular recognition site; other site 657324004767 dimerization interface [polypeptide binding]; other site 657324004768 flagellar motor switch protein; Validated; Region: PRK08119 657324004769 CheC-like family; Region: CheC; pfam04509 657324004770 CheC-like family; Region: CheC; pfam04509 657324004771 flagellar motor switch protein FliN; Region: fliN; TIGR02480 657324004772 Flagellar motor switch protein FliM; Region: FliM; pfam02154 657324004773 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 657324004774 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 657324004775 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 657324004776 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 657324004777 ligand binding site [chemical binding]; other site 657324004778 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 657324004779 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657324004780 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 657324004781 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 657324004782 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 657324004783 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 657324004784 Uncharacterized conserved protein [Function unknown]; Region: COG3334 657324004785 Flagellar assembly protein FliH; Region: FliH; pfam02108 657324004786 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 657324004787 FliG C-terminal domain; Region: FliG_C; pfam01706 657324004788 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 657324004789 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 657324004790 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 657324004791 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 657324004792 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657324004793 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 657324004794 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 657324004795 transcriptional repressor CodY; Validated; Region: PRK04158 657324004796 CodY GAF-like domain; Region: CodY; pfam06018 657324004797 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 657324004798 DNA topoisomerase I; Validated; Region: PRK05582 657324004799 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 657324004800 active site 657324004801 interdomain interaction site; other site 657324004802 putative metal-binding site [ion binding]; other site 657324004803 nucleotide binding site [chemical binding]; other site 657324004804 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 657324004805 domain I; other site 657324004806 DNA binding groove [nucleotide binding] 657324004807 phosphate binding site [ion binding]; other site 657324004808 domain II; other site 657324004809 domain III; other site 657324004810 nucleotide binding site [chemical binding]; other site 657324004811 catalytic site [active] 657324004812 domain IV; other site 657324004813 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 657324004814 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 657324004815 DNA protecting protein DprA; Region: dprA; TIGR00732 657324004816 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 657324004817 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 657324004818 DNA protecting protein DprA; Region: dprA; TIGR00732 657324004819 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 657324004820 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 657324004821 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 657324004822 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 657324004823 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 657324004824 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 657324004825 active site 657324004826 HIGH motif; other site 657324004827 dimer interface [polypeptide binding]; other site 657324004828 KMSKS motif; other site 657324004829 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 657324004830 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 657324004831 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 657324004832 active site 657324004833 catalytic site [active] 657324004834 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 657324004835 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 657324004836 Part of AAA domain; Region: AAA_19; pfam13245 657324004837 Family description; Region: UvrD_C_2; pfam13538 657324004838 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 657324004839 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 657324004840 active site 657324004841 HIGH motif; other site 657324004842 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 657324004843 active site 657324004844 KMSKS motif; other site 657324004845 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 657324004846 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 657324004847 putative metal binding residues [ion binding]; other site 657324004848 signature motif; other site 657324004849 dimer interface [polypeptide binding]; other site 657324004850 active site 657324004851 polyP binding site; other site 657324004852 substrate binding site [chemical binding]; other site 657324004853 acceptor-phosphate pocket; other site 657324004854 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 657324004855 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 657324004856 nucleotide binding site [chemical binding]; other site 657324004857 NEF interaction site [polypeptide binding]; other site 657324004858 SBD interface [polypeptide binding]; other site 657324004859 GrpE; Region: GrpE; pfam01025 657324004860 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 657324004861 dimer interface [polypeptide binding]; other site 657324004862 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 657324004863 HrcA protein C terminal domain; Region: HrcA; pfam01628 657324004864 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 657324004865 GTP-binding protein LepA; Provisional; Region: PRK05433 657324004866 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 657324004867 G1 box; other site 657324004868 putative GEF interaction site [polypeptide binding]; other site 657324004869 GTP/Mg2+ binding site [chemical binding]; other site 657324004870 Switch I region; other site 657324004871 G2 box; other site 657324004872 G3 box; other site 657324004873 Switch II region; other site 657324004874 G4 box; other site 657324004875 G5 box; other site 657324004876 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 657324004877 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 657324004878 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 657324004879 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 657324004880 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324004881 FeS/SAM binding site; other site 657324004882 HemN C-terminal domain; Region: HemN_C; pfam06969 657324004883 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 657324004884 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 657324004885 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 657324004886 FMN binding site [chemical binding]; other site 657324004887 active site 657324004888 catalytic residues [active] 657324004889 substrate binding site [chemical binding]; other site 657324004890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324004891 I-site; other site 657324004892 active site 657324004893 metal binding site [ion binding]; metal-binding site 657324004894 DNA polymerase III, delta subunit; Region: holA; TIGR01128 657324004895 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 657324004896 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657324004897 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657324004898 active site 657324004899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324004900 dimer interface [polypeptide binding]; other site 657324004901 conserved gate region; other site 657324004902 putative PBP binding loops; other site 657324004903 ABC-ATPase subunit interface; other site 657324004904 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657324004905 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657324004906 substrate binding pocket [chemical binding]; other site 657324004907 membrane-bound complex binding site; other site 657324004908 hinge residues; other site 657324004909 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 657324004910 active site 657324004911 catalytic triad [active] 657324004912 oxyanion hole [active] 657324004913 Radical SAM superfamily; Region: Radical_SAM; pfam04055 657324004914 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324004915 FeS/SAM binding site; other site 657324004916 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 657324004917 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 657324004918 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 657324004919 active site 657324004920 dimer interface [polypeptide binding]; other site 657324004921 motif 1; other site 657324004922 motif 2; other site 657324004923 motif 3; other site 657324004924 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 657324004925 anticodon binding site; other site 657324004926 Pathogenicity factor; Region: AvrE; pfam11725 657324004927 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 657324004928 putative active site [active] 657324004929 nucleotide binding site [chemical binding]; other site 657324004930 nudix motif; other site 657324004931 putative metal binding site [ion binding]; other site 657324004932 TM1410 hypothetical-related protein; Region: DUF297; cl00997 657324004933 Competence protein; Region: Competence; pfam03772 657324004934 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 657324004935 Sporulation and spore germination; Region: Germane; pfam10646 657324004936 Sporulation and spore germination; Region: Germane; pfam10646 657324004937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657324004938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657324004939 dimer interface [polypeptide binding]; other site 657324004940 phosphorylation site [posttranslational modification] 657324004941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324004942 ATP binding site [chemical binding]; other site 657324004943 Mg2+ binding site [ion binding]; other site 657324004944 G-X-G motif; other site 657324004945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657324004946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324004947 active site 657324004948 phosphorylation site [posttranslational modification] 657324004949 intermolecular recognition site; other site 657324004950 dimerization interface [polypeptide binding]; other site 657324004951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657324004952 DNA binding site [nucleotide binding] 657324004953 SLBB domain; Region: SLBB; pfam10531 657324004954 comEA protein; Region: comE; TIGR01259 657324004955 acetylornithine aminotransferase; Provisional; Region: PRK02627 657324004956 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 657324004957 inhibitor-cofactor binding pocket; inhibition site 657324004958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324004959 catalytic residue [active] 657324004960 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 657324004961 feedback inhibition sensing region; other site 657324004962 homohexameric interface [polypeptide binding]; other site 657324004963 nucleotide binding site [chemical binding]; other site 657324004964 N-acetyl-L-glutamate binding site [chemical binding]; other site 657324004965 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 657324004966 heterotetramer interface [polypeptide binding]; other site 657324004967 active site pocket [active] 657324004968 cleavage site 657324004969 putative acetyltransferase; Provisional; Region: PRK03624 657324004970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324004971 Coenzyme A binding pocket [chemical binding]; other site 657324004972 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 657324004973 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 657324004974 argininosuccinate synthase; Provisional; Region: PRK13820 657324004975 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 657324004976 ANP binding site [chemical binding]; other site 657324004977 Substrate Binding Site II [chemical binding]; other site 657324004978 Substrate Binding Site I [chemical binding]; other site 657324004979 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 657324004980 Predicted transcriptional regulator [Transcription]; Region: COG3655 657324004981 salt bridge; other site 657324004982 non-specific DNA binding site [nucleotide binding]; other site 657324004983 sequence-specific DNA binding site [nucleotide binding]; other site 657324004984 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 657324004985 active site 657324004986 putative catalytic site [active] 657324004987 DNA binding site [nucleotide binding] 657324004988 putative phosphate binding site [ion binding]; other site 657324004989 metal binding site A [ion binding]; metal-binding site 657324004990 AP binding site [nucleotide binding]; other site 657324004991 metal binding site B [ion binding]; metal-binding site 657324004992 Cellulose binding domain; Region: CBM_2; pfam00553 657324004993 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 657324004994 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 657324004995 Cellulose binding domain; Region: CBM_2; cl17741 657324004996 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 657324004997 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 657324004998 Cellulose binding domain; Region: CBM_2; pfam00553 657324004999 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657324005000 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 657324005001 FtsX-like permease family; Region: FtsX; pfam02687 657324005002 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 657324005003 E3 interaction surface; other site 657324005004 lipoyl attachment site [posttranslational modification]; other site 657324005005 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657324005006 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657324005007 Walker A/P-loop; other site 657324005008 ATP binding site [chemical binding]; other site 657324005009 Q-loop/lid; other site 657324005010 ABC transporter signature motif; other site 657324005011 Walker B; other site 657324005012 D-loop; other site 657324005013 H-loop/switch region; other site 657324005014 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 657324005015 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 657324005016 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 657324005017 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 657324005018 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 657324005019 homodimer interface [polypeptide binding]; other site 657324005020 NADP binding site [chemical binding]; other site 657324005021 substrate binding site [chemical binding]; other site 657324005022 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 657324005023 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 657324005024 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 657324005025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324005026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324005027 metal binding site [ion binding]; metal-binding site 657324005028 active site 657324005029 I-site; other site 657324005030 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 657324005031 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657324005032 substrate binding site [chemical binding]; other site 657324005033 ATP binding site [chemical binding]; other site 657324005034 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657324005035 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 657324005036 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 657324005037 3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065 657324005038 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 657324005039 substrate binding site [chemical binding]; other site 657324005040 ligand binding site [chemical binding]; other site 657324005041 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 657324005042 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 657324005043 substrate binding site [chemical binding]; other site 657324005044 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 657324005045 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 657324005046 substrate binding site [chemical binding]; other site 657324005047 ligand binding site [chemical binding]; other site 657324005048 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 657324005049 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 657324005050 substrate binding site [chemical binding]; other site 657324005051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 657324005052 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 657324005053 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 657324005054 alanine racemase; Reviewed; Region: alr; PRK00053 657324005055 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 657324005056 active site 657324005057 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657324005058 dimer interface [polypeptide binding]; other site 657324005059 substrate binding site [chemical binding]; other site 657324005060 catalytic residues [active] 657324005061 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657324005062 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 657324005063 Walker A/P-loop; other site 657324005064 ATP binding site [chemical binding]; other site 657324005065 Q-loop/lid; other site 657324005066 ABC transporter signature motif; other site 657324005067 Walker B; other site 657324005068 D-loop; other site 657324005069 H-loop/switch region; other site 657324005070 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657324005071 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657324005072 membrane-bound complex binding site; other site 657324005073 hinge residues; other site 657324005074 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657324005075 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657324005076 substrate binding pocket [chemical binding]; other site 657324005077 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 657324005078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324005079 dimer interface [polypeptide binding]; other site 657324005080 conserved gate region; other site 657324005081 putative PBP binding loops; other site 657324005082 ABC-ATPase subunit interface; other site 657324005083 Low molecular weight phosphatase family; Region: LMWPc; cl00105 657324005084 Putative integral membrane protein DUF46; Region: DUF46; cl17511 657324005085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 657324005086 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 657324005087 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657324005088 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 657324005089 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 657324005090 putative sugar binding sites [chemical binding]; other site 657324005091 Q-X-W motif; other site 657324005092 Cellulose binding domain; Region: CBM_2; pfam00553 657324005093 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 657324005094 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 657324005095 MraW methylase family; Region: Methyltransf_5; cl17771 657324005096 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 657324005097 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 657324005098 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 657324005099 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 657324005100 substrate binding pocket [chemical binding]; other site 657324005101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657324005102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657324005103 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 657324005104 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 657324005105 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 657324005106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 657324005107 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 657324005108 anti sigma factor interaction site; other site 657324005109 regulatory phosphorylation site [posttranslational modification]; other site 657324005110 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 657324005111 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 657324005112 Ligand Binding Site [chemical binding]; other site 657324005113 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 657324005114 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657324005115 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657324005116 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 657324005117 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657324005118 active site 657324005119 metal binding site [ion binding]; metal-binding site 657324005120 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 657324005121 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 657324005122 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 657324005123 Ca binding site [ion binding]; other site 657324005124 carbohydrate binding site [chemical binding]; other site 657324005125 hypothetical protein; Provisional; Region: PRK06762 657324005126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657324005127 dimerization interface [polypeptide binding]; other site 657324005128 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324005129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324005130 dimer interface [polypeptide binding]; other site 657324005131 putative CheW interface [polypeptide binding]; other site 657324005132 Cache domain; Region: Cache_1; pfam02743 657324005133 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657324005134 dimerization interface [polypeptide binding]; other site 657324005135 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324005136 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324005137 dimer interface [polypeptide binding]; other site 657324005138 putative CheW interface [polypeptide binding]; other site 657324005139 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 657324005140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657324005141 putative substrate translocation pore; other site 657324005142 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 657324005143 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 657324005144 active site 657324005145 FMN binding site [chemical binding]; other site 657324005146 substrate binding site [chemical binding]; other site 657324005147 putative catalytic residue [active] 657324005148 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657324005149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657324005150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657324005151 dimerization interface [polypeptide binding]; other site 657324005152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657324005153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657324005154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657324005155 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 657324005156 active site 657324005157 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 657324005158 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 657324005159 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657324005160 alpha-galactosidase; Region: PLN02808; cl17638 657324005161 LrgB-like family; Region: LrgB; pfam04172 657324005162 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 657324005163 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 657324005164 active site 657324005165 SAM binding site [chemical binding]; other site 657324005166 homodimer interface [polypeptide binding]; other site 657324005167 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 657324005168 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 657324005169 FIC domain binding interface [polypeptide binding]; other site 657324005170 Fic/DOC family; Region: Fic; pfam02661 657324005171 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 657324005172 Uncharacterized conserved protein [Function unknown]; Region: COG2433 657324005173 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 657324005174 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657324005175 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 657324005176 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 657324005177 TAP-like protein; Region: Abhydrolase_4; pfam08386 657324005178 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 657324005179 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 657324005180 active site 657324005181 catalytic tetrad [active] 657324005182 Uncharacterized conserved protein [Function unknown]; Region: COG1359 657324005183 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 657324005184 GAF domain; Region: GAF_2; pfam13185 657324005185 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 657324005186 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 657324005187 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 657324005188 DNA binding residues [nucleotide binding] 657324005189 dimer interface [polypeptide binding]; other site 657324005190 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 657324005191 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 657324005192 NAD(P) binding site [chemical binding]; other site 657324005193 catalytic residues [active] 657324005194 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 657324005195 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 657324005196 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 657324005197 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 657324005198 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 657324005199 ATP-grasp domain; Region: ATP-grasp_4; cl17255 657324005200 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 657324005201 IMP binding site; other site 657324005202 dimer interface [polypeptide binding]; other site 657324005203 interdomain contacts; other site 657324005204 partial ornithine binding site; other site 657324005205 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 657324005206 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 657324005207 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 657324005208 catalytic site [active] 657324005209 subunit interface [polypeptide binding]; other site 657324005210 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 657324005211 DEAD_2; Region: DEAD_2; pfam06733 657324005212 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 657324005213 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 657324005214 regulatory protein interface [polypeptide binding]; other site 657324005215 regulatory phosphorylation site [posttranslational modification]; other site 657324005216 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 657324005217 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 657324005218 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657324005219 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 657324005220 active site turn [active] 657324005221 phosphorylation site [posttranslational modification] 657324005222 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657324005223 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 657324005224 HPr interaction site; other site 657324005225 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657324005226 active site 657324005227 phosphorylation site [posttranslational modification] 657324005228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657324005229 DNA-binding site [nucleotide binding]; DNA binding site 657324005230 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 657324005231 UTRA domain; Region: UTRA; pfam07702 657324005232 Predicted permeases [General function prediction only]; Region: COG0679 657324005233 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 657324005234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657324005235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324005236 homodimer interface [polypeptide binding]; other site 657324005237 catalytic residue [active] 657324005238 Amidinotransferase; Region: Amidinotransf; cl12043 657324005239 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 657324005240 Amidinotransferase; Region: Amidinotransf; pfam02274 657324005241 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 657324005242 metal binding site [ion binding]; metal-binding site 657324005243 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657324005244 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 657324005245 Walker A/P-loop; other site 657324005246 ATP binding site [chemical binding]; other site 657324005247 Q-loop/lid; other site 657324005248 ABC transporter signature motif; other site 657324005249 Walker B; other site 657324005250 D-loop; other site 657324005251 H-loop/switch region; other site 657324005252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324005253 ABC-ATPase subunit interface; other site 657324005254 putative PBP binding loops; other site 657324005255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 657324005256 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 657324005257 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 657324005258 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 657324005259 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 657324005260 catalytic triad [active] 657324005261 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 657324005262 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 657324005263 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 657324005264 active site 657324005265 Zn binding site [ion binding]; other site 657324005266 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 657324005267 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 657324005268 active site 657324005269 Zn binding site [ion binding]; other site 657324005270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 657324005271 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 657324005272 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 657324005273 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 657324005274 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 657324005275 trimer interface [polypeptide binding]; other site 657324005276 active site 657324005277 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 657324005278 catalytic site [active] 657324005279 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 657324005280 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 657324005281 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 657324005282 Ligand Binding Site [chemical binding]; other site 657324005283 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 657324005284 GTP cyclohydrolase I; Provisional; Region: PLN03044 657324005285 active site 657324005286 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 657324005287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324005288 FeS/SAM binding site; other site 657324005289 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 657324005290 active site 657324005291 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 657324005292 CBD_II domain; Region: CBD_II; smart00637 657324005293 pyrroline-5-carboxylate reductase; Region: PLN02688 657324005294 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 657324005295 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 657324005296 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 657324005297 ligand binding site [chemical binding]; other site 657324005298 metal binding site [ion binding]; metal-binding site 657324005299 CBD_II domain; Region: CBD_II; smart00637 657324005300 CBD_II domain; Region: CBD_II; smart00637 657324005301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657324005302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 657324005303 putative substrate translocation pore; other site 657324005304 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 657324005305 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 657324005306 active site 657324005307 catalytic tetrad [active] 657324005308 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 657324005309 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 657324005310 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657324005311 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657324005312 catalytic residue [active] 657324005313 recombination factor protein RarA; Reviewed; Region: PRK13342 657324005314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324005315 Walker A motif; other site 657324005316 ATP binding site [chemical binding]; other site 657324005317 Walker B motif; other site 657324005318 arginine finger; other site 657324005319 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 657324005320 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657324005321 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 657324005322 putative substrate binding site [chemical binding]; other site 657324005323 putative ATP binding site [chemical binding]; other site 657324005324 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 657324005325 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 657324005326 substrate binding [chemical binding]; other site 657324005327 active site 657324005328 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 657324005329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324005330 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657324005331 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324005332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324005333 dimer interface [polypeptide binding]; other site 657324005334 conserved gate region; other site 657324005335 putative PBP binding loops; other site 657324005336 ABC-ATPase subunit interface; other site 657324005337 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324005338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324005339 DNA binding site [nucleotide binding] 657324005340 domain linker motif; other site 657324005341 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324005342 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 657324005343 active site 657324005344 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 657324005345 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657324005346 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657324005347 DNA binding site [nucleotide binding] 657324005348 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324005349 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 657324005350 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 657324005351 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 657324005352 tetramerization interface [polypeptide binding]; other site 657324005353 active site 657324005354 pantoate--beta-alanine ligase; Region: panC; TIGR00018 657324005355 Pantoate-beta-alanine ligase; Region: PanC; cd00560 657324005356 active site 657324005357 ATP-binding site [chemical binding]; other site 657324005358 pantoate-binding site; other site 657324005359 HXXH motif; other site 657324005360 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 657324005361 active site 657324005362 oligomerization interface [polypeptide binding]; other site 657324005363 metal binding site [ion binding]; metal-binding site 657324005364 Uncharacterized conserved protein [Function unknown]; Region: COG5495 657324005365 Rossmann-like domain; Region: Rossmann-like; pfam10727 657324005366 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 657324005367 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 657324005368 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 657324005369 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 657324005370 L-serine binding site [chemical binding]; other site 657324005371 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 657324005372 substrate binding site [chemical binding]; other site 657324005373 active site 657324005374 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 657324005375 metal binding site [ion binding]; metal-binding site 657324005376 ligand binding site [chemical binding]; other site 657324005377 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 657324005378 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 657324005379 putative sugar binding sites [chemical binding]; other site 657324005380 Q-X-W motif; other site 657324005381 Cellulose binding domain; Region: CBM_2; pfam00553 657324005382 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 657324005383 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 657324005384 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 657324005385 putative sugar binding sites [chemical binding]; other site 657324005386 Q-X-W motif; other site 657324005387 Cellulose binding domain; Region: CBM_2; pfam00553 657324005388 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 657324005389 Clp amino terminal domain; Region: Clp_N; pfam02861 657324005390 Clp amino terminal domain; Region: Clp_N; pfam02861 657324005391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324005392 Walker A motif; other site 657324005393 ATP binding site [chemical binding]; other site 657324005394 Walker B motif; other site 657324005395 arginine finger; other site 657324005396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324005397 Walker A motif; other site 657324005398 ATP binding site [chemical binding]; other site 657324005399 Walker B motif; other site 657324005400 arginine finger; other site 657324005401 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 657324005402 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 657324005403 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657324005404 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657324005405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 657324005406 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 657324005407 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 657324005408 putative dimer interface [polypeptide binding]; other site 657324005409 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 657324005410 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657324005411 ABC-ATPase subunit interface; other site 657324005412 dimer interface [polypeptide binding]; other site 657324005413 putative PBP binding regions; other site 657324005414 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 657324005415 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 657324005416 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 657324005417 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 657324005418 intersubunit interface [polypeptide binding]; other site 657324005419 Cysteine-rich small domain; Region: zf-like; pfam04071 657324005420 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 657324005421 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 657324005422 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 657324005423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324005424 FeS/SAM binding site; other site 657324005425 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 657324005426 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 657324005427 dimer interface [polypeptide binding]; other site 657324005428 substrate binding site [chemical binding]; other site 657324005429 ATP binding site [chemical binding]; other site 657324005430 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 657324005431 thiamine phosphate binding site [chemical binding]; other site 657324005432 active site 657324005433 pyrophosphate binding site [ion binding]; other site 657324005434 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 657324005435 HicB family; Region: HicB; pfam05534 657324005436 Predicted transcriptional regulator [Transcription]; Region: COG2944 657324005437 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 657324005438 FMN binding site [chemical binding]; other site 657324005439 substrate binding site [chemical binding]; other site 657324005440 putative catalytic residue [active] 657324005441 Nitronate monooxygenase; Region: NMO; pfam03060 657324005442 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 657324005443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657324005444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324005445 homodimer interface [polypeptide binding]; other site 657324005446 catalytic residue [active] 657324005447 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 657324005448 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657324005449 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 657324005450 substrate binding site [chemical binding]; other site 657324005451 ATP binding site [chemical binding]; other site 657324005452 Glucuronate isomerase; Region: UxaC; pfam02614 657324005453 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 657324005454 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 657324005455 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 657324005456 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 657324005457 mannonate dehydratase; Provisional; Region: PRK03906 657324005458 mannonate dehydratase; Region: uxuA; TIGR00695 657324005459 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 657324005460 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 657324005461 active site 657324005462 intersubunit interface [polypeptide binding]; other site 657324005463 catalytic residue [active] 657324005464 Cupin domain; Region: Cupin_2; pfam07883 657324005465 Helix-turn-helix domain; Region: HTH_18; pfam12833 657324005466 Erythromycin esterase; Region: Erythro_esteras; cl17110 657324005467 FtsX-like permease family; Region: FtsX; pfam02687 657324005468 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657324005469 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657324005470 Walker A/P-loop; other site 657324005471 ATP binding site [chemical binding]; other site 657324005472 Q-loop/lid; other site 657324005473 ABC transporter signature motif; other site 657324005474 Walker B; other site 657324005475 D-loop; other site 657324005476 H-loop/switch region; other site 657324005477 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657324005478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324005479 active site 657324005480 phosphorylation site [posttranslational modification] 657324005481 intermolecular recognition site; other site 657324005482 dimerization interface [polypeptide binding]; other site 657324005483 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657324005484 DNA binding site [nucleotide binding] 657324005485 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 657324005486 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 657324005487 DNA binding residues [nucleotide binding] 657324005488 dimer interface [polypeptide binding]; other site 657324005489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324005490 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657324005491 Walker A/P-loop; other site 657324005492 ATP binding site [chemical binding]; other site 657324005493 Q-loop/lid; other site 657324005494 ABC transporter signature motif; other site 657324005495 Walker B; other site 657324005496 D-loop; other site 657324005497 H-loop/switch region; other site 657324005498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324005499 sequence-specific DNA binding site [nucleotide binding]; other site 657324005500 salt bridge; other site 657324005501 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 657324005502 reactive center loop; other site 657324005503 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 657324005504 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 657324005505 OPT oligopeptide transporter protein; Region: OPT; cl14607 657324005506 putative oligopeptide transporter, OPT family; Region: TIGR00733 657324005507 Rubredoxin [Energy production and conversion]; Region: COG1773 657324005508 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 657324005509 iron binding site [ion binding]; other site 657324005510 Rubrerythrin [Energy production and conversion]; Region: COG1592 657324005511 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 657324005512 diiron binding motif [ion binding]; other site 657324005513 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 657324005514 catalytic loop [active] 657324005515 iron binding site [ion binding]; other site 657324005516 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 657324005517 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657324005518 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657324005519 active site 657324005520 metal binding site [ion binding]; metal-binding site 657324005521 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 657324005522 active site 657324005523 dimerization interface [polypeptide binding]; other site 657324005524 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 657324005525 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 657324005526 active site 657324005527 metal binding site [ion binding]; metal-binding site 657324005528 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 657324005529 dimerization interface [polypeptide binding]; other site 657324005530 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 657324005531 ATP binding site [chemical binding]; other site 657324005532 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 657324005533 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 657324005534 Acylphosphatase; Region: Acylphosphatase; pfam00708 657324005535 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 657324005536 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657324005537 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 657324005538 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 657324005539 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 657324005540 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 657324005541 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 657324005542 NADH dehydrogenase; Region: NADHdh; cl00469 657324005543 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 657324005544 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 657324005545 4Fe-4S binding domain; Region: Fer4; pfam00037 657324005546 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 657324005547 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 657324005548 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 657324005549 G1 box; other site 657324005550 GTP/Mg2+ binding site [chemical binding]; other site 657324005551 Switch I region; other site 657324005552 G2 box; other site 657324005553 Switch II region; other site 657324005554 G3 box; other site 657324005555 G4 box; other site 657324005556 G5 box; other site 657324005557 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 657324005558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324005559 FeS/SAM binding site; other site 657324005560 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 657324005561 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 657324005562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324005563 FeS/SAM binding site; other site 657324005564 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 657324005565 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 657324005566 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657324005567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324005568 active site 657324005569 phosphorylation site [posttranslational modification] 657324005570 intermolecular recognition site; other site 657324005571 dimerization interface [polypeptide binding]; other site 657324005572 LytTr DNA-binding domain; Region: LytTR; smart00850 657324005573 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 657324005574 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 657324005575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657324005576 dimer interface [polypeptide binding]; other site 657324005577 phosphorylation site [posttranslational modification] 657324005578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657324005579 ATP binding site [chemical binding]; other site 657324005580 Mg2+ binding site [ion binding]; other site 657324005581 G-X-G motif; other site 657324005582 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 657324005583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324005584 active site 657324005585 phosphorylation site [posttranslational modification] 657324005586 intermolecular recognition site; other site 657324005587 dimerization interface [polypeptide binding]; other site 657324005588 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 657324005589 putative binding surface; other site 657324005590 active site 657324005591 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 657324005592 FlxA-like protein; Region: FlxA; pfam14282 657324005593 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657324005594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324005595 active site 657324005596 phosphorylation site [posttranslational modification] 657324005597 intermolecular recognition site; other site 657324005598 dimerization interface [polypeptide binding]; other site 657324005599 LytTr DNA-binding domain; Region: LytTR; pfam04397 657324005600 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 657324005601 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 657324005602 active site 657324005603 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657324005604 substrate binding site [chemical binding]; other site 657324005605 catalytic residues [active] 657324005606 dimer interface [polypeptide binding]; other site 657324005607 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 657324005608 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 657324005609 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 657324005610 RNA/DNA hybrid binding site [nucleotide binding]; other site 657324005611 active site 657324005612 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 657324005613 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 657324005614 putative oligomer interface [polypeptide binding]; other site 657324005615 putative active site [active] 657324005616 metal binding site [ion binding]; metal-binding site 657324005617 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 657324005618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 657324005619 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 657324005620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324005621 dimer interface [polypeptide binding]; other site 657324005622 conserved gate region; other site 657324005623 putative PBP binding loops; other site 657324005624 ABC-ATPase subunit interface; other site 657324005625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324005626 Walker A/P-loop; other site 657324005627 ATP binding site [chemical binding]; other site 657324005628 Q-loop/lid; other site 657324005629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 657324005630 ABC transporter signature motif; other site 657324005631 Walker B; other site 657324005632 D-loop; other site 657324005633 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 657324005634 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 657324005635 synthetase active site [active] 657324005636 NTP binding site [chemical binding]; other site 657324005637 metal binding site [ion binding]; metal-binding site 657324005638 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657324005639 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657324005640 6-phosphofructokinase; Provisional; Region: PRK03202 657324005641 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 657324005642 active site 657324005643 ADP/pyrophosphate binding site [chemical binding]; other site 657324005644 dimerization interface [polypeptide binding]; other site 657324005645 allosteric effector site; other site 657324005646 fructose-1,6-bisphosphate binding site; other site 657324005647 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 657324005648 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 657324005649 active site 657324005650 PHP Thumb interface [polypeptide binding]; other site 657324005651 metal binding site [ion binding]; metal-binding site 657324005652 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 657324005653 generic binding surface II; other site 657324005654 generic binding surface I; other site 657324005655 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 657324005656 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 657324005657 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 657324005658 PhoU domain; Region: PhoU; pfam01895 657324005659 PhoU domain; Region: PhoU; pfam01895 657324005660 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 657324005661 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 657324005662 HflX GTPase family; Region: HflX; cd01878 657324005663 G1 box; other site 657324005664 GTP/Mg2+ binding site [chemical binding]; other site 657324005665 Switch I region; other site 657324005666 G2 box; other site 657324005667 G3 box; other site 657324005668 Switch II region; other site 657324005669 G4 box; other site 657324005670 G5 box; other site 657324005671 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 657324005672 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 657324005673 anti sigma factor interaction site; other site 657324005674 regulatory phosphorylation site [posttranslational modification]; other site 657324005675 Response regulator receiver domain; Region: Response_reg; pfam00072 657324005676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324005677 active site 657324005678 phosphorylation site [posttranslational modification] 657324005679 intermolecular recognition site; other site 657324005680 dimerization interface [polypeptide binding]; other site 657324005681 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 657324005682 Transcriptional regulators [Transcription]; Region: GntR; COG1802 657324005683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657324005684 DNA-binding site [nucleotide binding]; DNA binding site 657324005685 FCD domain; Region: FCD; pfam07729 657324005686 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 657324005687 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 657324005688 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 657324005689 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 657324005690 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 657324005691 acyl-activating enzyme (AAE) consensus motif; other site 657324005692 AMP binding site [chemical binding]; other site 657324005693 active site 657324005694 CoA binding site [chemical binding]; other site 657324005695 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 657324005696 Phosphopantetheine attachment site; Region: PP-binding; cl09936 657324005697 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657324005698 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 657324005699 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657324005700 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324005701 Zn2+ binding site [ion binding]; other site 657324005702 Mg2+ binding site [ion binding]; other site 657324005703 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 657324005704 TM-ABC transporter signature motif; other site 657324005705 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657324005706 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 657324005707 TM-ABC transporter signature motif; other site 657324005708 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 657324005709 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 657324005710 Walker A/P-loop; other site 657324005711 ATP binding site [chemical binding]; other site 657324005712 Q-loop/lid; other site 657324005713 ABC transporter signature motif; other site 657324005714 Walker B; other site 657324005715 D-loop; other site 657324005716 H-loop/switch region; other site 657324005717 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 657324005718 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 657324005719 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324005720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657324005721 TPR repeat; Region: TPR_11; pfam13414 657324005722 binding surface 657324005723 TPR motif; other site 657324005724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 657324005725 binding surface 657324005726 TPR motif; other site 657324005727 Tetratricopeptide repeat; Region: TPR_16; pfam13432 657324005728 Protein of unknown function (DUF342); Region: DUF342; pfam03961 657324005729 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 657324005730 intersubunit interface [polypeptide binding]; other site 657324005731 active site 657324005732 catalytic residue [active] 657324005733 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 657324005734 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 657324005735 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657324005736 active site 657324005737 HIGH motif; other site 657324005738 nucleotide binding site [chemical binding]; other site 657324005739 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 657324005740 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 657324005741 active site 657324005742 KMSKS motif; other site 657324005743 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 657324005744 tRNA binding surface [nucleotide binding]; other site 657324005745 anticodon binding site; other site 657324005746 PIN domain; Region: PIN_3; cl17397 657324005747 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 657324005748 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 657324005749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324005750 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657324005751 active site 657324005752 motif I; other site 657324005753 motif II; other site 657324005754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324005755 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 657324005756 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657324005757 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 657324005758 Probable Catalytic site; other site 657324005759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657324005760 active site 657324005761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657324005762 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 657324005763 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657324005764 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 657324005765 substrate binding site; other site 657324005766 dimerization interface; other site 657324005767 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 657324005768 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657324005769 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657324005770 active site 657324005771 WbqC-like protein family; Region: WbqC; pfam08889 657324005772 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 657324005773 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 657324005774 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 657324005775 inhibitor-cofactor binding pocket; inhibition site 657324005776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324005777 catalytic residue [active] 657324005778 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 657324005779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657324005780 active site 657324005781 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657324005782 active site 657324005783 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 657324005784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324005785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657324005786 active site 657324005787 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324005788 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324005789 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 657324005790 Chain length determinant protein; Region: Wzz; cl15801 657324005791 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 657324005792 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 657324005793 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657324005794 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 657324005795 putative metal binding residues [ion binding]; other site 657324005796 signature motif; other site 657324005797 dimer interface [polypeptide binding]; other site 657324005798 active site 657324005799 polyP binding site; other site 657324005800 substrate binding site [chemical binding]; other site 657324005801 acceptor-phosphate pocket; other site 657324005802 CotH protein; Region: CotH; pfam08757 657324005803 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324005804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324005805 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 657324005806 trimer interface [polypeptide binding]; other site 657324005807 active site 657324005808 substrate binding site [chemical binding]; other site 657324005809 CoA binding site [chemical binding]; other site 657324005810 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 657324005811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657324005812 active site 657324005813 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324005814 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324005815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324005816 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 657324005817 putative ADP-binding pocket [chemical binding]; other site 657324005818 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 657324005819 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 657324005820 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 657324005821 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 657324005822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324005823 FeS/SAM binding site; other site 657324005824 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 657324005825 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657324005826 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324005827 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 657324005828 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 657324005829 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657324005830 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657324005831 active site 657324005832 metal binding site [ion binding]; metal-binding site 657324005833 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 657324005834 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324005835 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324005836 non-specific DNA binding site [nucleotide binding]; other site 657324005837 salt bridge; other site 657324005838 sequence-specific DNA binding site [nucleotide binding]; other site 657324005839 GTPase; Provisional; Region: PRK13768 657324005840 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 657324005841 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324005842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324005843 non-specific DNA binding site [nucleotide binding]; other site 657324005844 salt bridge; other site 657324005845 sequence-specific DNA binding site [nucleotide binding]; other site 657324005846 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 657324005847 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 657324005848 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 657324005849 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 657324005850 carbamate kinase; Reviewed; Region: PRK12686 657324005851 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 657324005852 putative substrate binding site [chemical binding]; other site 657324005853 nucleotide binding site [chemical binding]; other site 657324005854 nucleotide binding site [chemical binding]; other site 657324005855 homodimer interface [polypeptide binding]; other site 657324005856 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 657324005857 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 657324005858 protein binding site [polypeptide binding]; other site 657324005859 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 657324005860 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 657324005861 glutaminase active site [active] 657324005862 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 657324005863 dimer interface [polypeptide binding]; other site 657324005864 active site 657324005865 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 657324005866 dimer interface [polypeptide binding]; other site 657324005867 active site 657324005868 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 657324005869 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657324005870 active site 657324005871 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657324005872 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 657324005873 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 657324005874 Probable Catalytic site; other site 657324005875 metal-binding site 657324005876 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 657324005877 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 657324005878 Probable Catalytic site; other site 657324005879 metal-binding site 657324005880 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 657324005881 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 657324005882 Rhamnan synthesis protein F; Region: RgpF; pfam05045 657324005883 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 657324005884 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 657324005885 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 657324005886 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 657324005887 Walker A/P-loop; other site 657324005888 ATP binding site [chemical binding]; other site 657324005889 Q-loop/lid; other site 657324005890 ABC transporter signature motif; other site 657324005891 Walker B; other site 657324005892 D-loop; other site 657324005893 H-loop/switch region; other site 657324005894 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 657324005895 putative carbohydrate binding site [chemical binding]; other site 657324005896 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 657324005897 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 657324005898 active site 657324005899 catalytic site [active] 657324005900 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 657324005901 thymidine kinase; Provisional; Region: PRK04296 657324005902 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324005903 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324005904 metal binding site [ion binding]; metal-binding site 657324005905 active site 657324005906 I-site; other site 657324005907 VanW like protein; Region: VanW; pfam04294 657324005908 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 657324005909 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324005910 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 657324005911 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657324005912 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657324005913 Walker A/P-loop; other site 657324005914 ATP binding site [chemical binding]; other site 657324005915 Q-loop/lid; other site 657324005916 ABC transporter signature motif; other site 657324005917 Walker B; other site 657324005918 D-loop; other site 657324005919 H-loop/switch region; other site 657324005920 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657324005921 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 657324005922 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 657324005923 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657324005924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657324005925 catalytic residue [active] 657324005926 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 657324005927 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 657324005928 putative trimer interface [polypeptide binding]; other site 657324005929 putative CoA binding site [chemical binding]; other site 657324005930 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 657324005931 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 657324005932 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 657324005933 NAD(P) binding site [chemical binding]; other site 657324005934 homodimer interface [polypeptide binding]; other site 657324005935 substrate binding site [chemical binding]; other site 657324005936 active site 657324005937 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 657324005938 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 657324005939 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 657324005940 active site 657324005941 homodimer interface [polypeptide binding]; other site 657324005942 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 657324005943 Ligand binding site; other site 657324005944 Putative Catalytic site; other site 657324005945 DXD motif; other site 657324005946 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 657324005947 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 657324005948 inhibitor-cofactor binding pocket; inhibition site 657324005949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324005950 catalytic residue [active] 657324005951 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 657324005952 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 657324005953 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 657324005954 Ligand binding site; other site 657324005955 Putative Catalytic site; other site 657324005956 DXD motif; other site 657324005957 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 657324005958 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 657324005959 NAD(P) binding site [chemical binding]; other site 657324005960 homodimer interface [polypeptide binding]; other site 657324005961 substrate binding site [chemical binding]; other site 657324005962 active site 657324005963 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 657324005964 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 657324005965 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 657324005966 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 657324005967 TSC-22/dip/bun family; Region: TSC22; pfam01166 657324005968 AAA domain; Region: AAA_21; pfam13304 657324005969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324005970 sequence-specific DNA binding site [nucleotide binding]; other site 657324005971 salt bridge; other site 657324005972 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 657324005973 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 657324005974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657324005975 ATP binding site [chemical binding]; other site 657324005976 putative Mg++ binding site [ion binding]; other site 657324005977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 657324005978 nucleotide binding region [chemical binding]; other site 657324005979 ATP-binding site [chemical binding]; other site 657324005980 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 657324005981 PLD-like domain; Region: PLDc_2; pfam13091 657324005982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 657324005983 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 657324005984 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 657324005985 Rubredoxin; Region: Rubredoxin; pfam00301 657324005986 iron binding site [ion binding]; other site 657324005987 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 657324005988 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 657324005989 Rubredoxin; Region: Rubredoxin; pfam00301 657324005990 iron binding site [ion binding]; other site 657324005991 AAA domain; Region: AAA_21; pfam13304 657324005992 AAA domain; Region: AAA_21; pfam13304 657324005993 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 657324005994 DNA protecting protein DprA; Region: dprA; TIGR00732 657324005995 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 657324005996 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 657324005997 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 657324005998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324005999 Walker A motif; other site 657324006000 ATP binding site [chemical binding]; other site 657324006001 Walker B motif; other site 657324006002 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 657324006003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 657324006004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324006005 non-specific DNA binding site [nucleotide binding]; other site 657324006006 salt bridge; other site 657324006007 sequence-specific DNA binding site [nucleotide binding]; other site 657324006008 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657324006009 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324006010 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324006011 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 657324006012 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 657324006013 active site 657324006014 metal binding site [ion binding]; metal-binding site 657324006015 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 657324006016 putative catalytic site [active] 657324006017 putative phosphate binding site [ion binding]; other site 657324006018 putative metal binding site [ion binding]; other site 657324006019 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 657324006020 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 657324006021 putative trimer interface [polypeptide binding]; other site 657324006022 putative CoA binding site [chemical binding]; other site 657324006023 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 657324006024 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 657324006025 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 657324006026 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 657324006027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 657324006028 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 657324006029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 657324006030 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 657324006031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 657324006032 Transposase; Region: HTH_Tnp_1; cl17663 657324006033 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 657324006034 Methyltransferase domain; Region: Methyltransf_31; pfam13847 657324006035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324006036 S-adenosylmethionine binding site [chemical binding]; other site 657324006037 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 657324006038 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 657324006039 active site 657324006040 metal-binding site 657324006041 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 657324006042 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657324006043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324006044 homodimer interface [polypeptide binding]; other site 657324006045 catalytic residue [active] 657324006046 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 657324006047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 657324006048 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324006049 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324006050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324006051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324006052 WxcM-like, C-terminal; Region: FdtA; pfam05523 657324006053 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 657324006054 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 657324006055 inhibitor-cofactor binding pocket; inhibition site 657324006056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324006057 catalytic residue [active] 657324006058 Integrase core domain; Region: rve_3; cl15866 657324006059 Transposase; Region: HTH_Tnp_1; cl17663 657324006060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324006061 active site 657324006062 motif I; other site 657324006063 motif II; other site 657324006064 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 657324006065 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657324006066 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 657324006067 Ligand binding site; other site 657324006068 Putative Catalytic site; other site 657324006069 DXD motif; other site 657324006070 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324006071 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 657324006072 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 657324006073 Fic/DOC family; Region: Fic; pfam02661 657324006074 acyl carrier protein; Provisional; Region: PRK07081 657324006075 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 657324006076 AMP-binding enzyme; Region: AMP-binding; pfam00501 657324006077 acyl-activating enzyme (AAE) consensus motif; other site 657324006078 AMP binding site [chemical binding]; other site 657324006079 Conjugative transposon protein TraO; Region: TraO; pfam10626 657324006080 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 657324006081 putative trimer interface [polypeptide binding]; other site 657324006082 putative CoA binding site [chemical binding]; other site 657324006083 integral membrane protein MviN; Region: mviN; TIGR01695 657324006084 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 657324006085 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657324006086 Sulfatase; Region: Sulfatase; cl17466 657324006087 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 657324006088 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 657324006089 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 657324006090 active site 657324006091 catalytic residues [active] 657324006092 metal binding site [ion binding]; metal-binding site 657324006093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657324006094 active site 657324006095 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 657324006096 trimer interface [polypeptide binding]; other site 657324006097 active site 657324006098 substrate binding site [chemical binding]; other site 657324006099 CoA binding site [chemical binding]; other site 657324006100 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 657324006101 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 657324006102 Ligand binding site; other site 657324006103 Putative Catalytic site; other site 657324006104 DXD motif; other site 657324006105 Protein of unknown function (DUF1422); Region: DUF1422; cl11649 657324006106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657324006107 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 657324006108 NAD(P) binding site [chemical binding]; other site 657324006109 active site 657324006110 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324006111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324006112 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657324006113 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 657324006114 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657324006115 O-Antigen ligase; Region: Wzy_C; pfam04932 657324006116 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 657324006117 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 657324006118 ligand binding site; other site 657324006119 tetramer interface; other site 657324006120 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 657324006121 NeuB family; Region: NeuB; pfam03102 657324006122 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 657324006123 NeuB binding interface [polypeptide binding]; other site 657324006124 putative substrate binding site [chemical binding]; other site 657324006125 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657324006126 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657324006127 active site 657324006128 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 657324006129 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 657324006130 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 657324006131 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 657324006132 Substrate binding site; other site 657324006133 metal-binding site 657324006134 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 657324006135 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 657324006136 NAD binding site [chemical binding]; other site 657324006137 substrate binding site [chemical binding]; other site 657324006138 active site 657324006139 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 657324006140 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657324006141 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 657324006142 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324006143 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 657324006144 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 657324006145 putative ADP-binding pocket [chemical binding]; other site 657324006146 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324006147 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657324006148 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 657324006149 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 657324006150 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 657324006151 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 657324006152 active site 657324006153 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 657324006154 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 657324006155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657324006156 UDP-galactopyranose mutase; Region: GLF; pfam03275 657324006157 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 657324006158 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 657324006159 NADP binding site [chemical binding]; other site 657324006160 active site 657324006161 putative substrate binding site [chemical binding]; other site 657324006162 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 657324006163 metal binding site [ion binding]; metal-binding site 657324006164 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 657324006165 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 657324006166 catalytic residues [active] 657324006167 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 657324006168 dimerization domain swap beta strand [polypeptide binding]; other site 657324006169 regulatory protein interface [polypeptide binding]; other site 657324006170 active site 657324006171 regulatory phosphorylation site [posttranslational modification]; other site 657324006172 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 657324006173 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 657324006174 active site 657324006175 substrate binding site [chemical binding]; other site 657324006176 metal binding site [ion binding]; metal-binding site 657324006177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 657324006178 YbbR-like protein; Region: YbbR; pfam07949 657324006179 YbbR-like protein; Region: YbbR; pfam07949 657324006180 flagellar operon protein TIGR03826; Region: YvyF 657324006181 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 657324006182 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657324006183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324006184 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 657324006185 putative ADP-binding pocket [chemical binding]; other site 657324006186 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 657324006187 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 657324006188 trimer interface [polypeptide binding]; other site 657324006189 active site 657324006190 substrate binding site [chemical binding]; other site 657324006191 CoA binding site [chemical binding]; other site 657324006192 flagellar capping protein; Validated; Region: fliD; PRK07737 657324006193 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 657324006194 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 657324006195 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 657324006196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657324006197 active site 657324006198 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657324006199 flagellin; Validated; Region: PRK08026 657324006200 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 657324006201 Flagellar protein FliS; Region: FliS; cl00654 657324006202 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 657324006203 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 657324006204 FlaG protein; Region: FlaG; pfam03646 657324006205 carbon storage regulator; Provisional; Region: PRK01712 657324006206 FliW protein; Region: FliW; cl00740 657324006207 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657324006208 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 657324006209 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657324006210 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 657324006211 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657324006212 FlgN protein; Region: FlgN; pfam05130 657324006213 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 657324006214 Predicted transcriptional regulators [Transcription]; Region: COG1725 657324006215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657324006216 DNA-binding site [nucleotide binding]; DNA binding site 657324006217 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 657324006218 active site 657324006219 dimer interfaces [polypeptide binding]; other site 657324006220 catalytic residues [active] 657324006221 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 657324006222 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 657324006223 active site 657324006224 dimer interface [polypeptide binding]; other site 657324006225 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 657324006226 dimer interface [polypeptide binding]; other site 657324006227 active site 657324006228 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657324006229 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657324006230 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 657324006231 Walker A/P-loop; other site 657324006232 ATP binding site [chemical binding]; other site 657324006233 Q-loop/lid; other site 657324006234 ABC transporter signature motif; other site 657324006235 Walker B; other site 657324006236 D-loop; other site 657324006237 H-loop/switch region; other site 657324006238 inner membrane transporter YjeM; Provisional; Region: PRK15238 657324006239 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 657324006240 putative acetyltransferase YhhY; Provisional; Region: PRK10140 657324006241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324006242 Coenzyme A binding pocket [chemical binding]; other site 657324006243 HipA N-terminal domain; Region: Couple_hipA; pfam13657 657324006244 HipA-like N-terminal domain; Region: HipA_N; pfam07805 657324006245 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 657324006246 HipA-like C-terminal domain; Region: HipA_C; pfam07804 657324006247 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324006248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324006249 non-specific DNA binding site [nucleotide binding]; other site 657324006250 salt bridge; other site 657324006251 sequence-specific DNA binding site [nucleotide binding]; other site 657324006252 Fic family protein [Function unknown]; Region: COG3177 657324006253 Fic/DOC family; Region: Fic; pfam02661 657324006254 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 657324006255 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 657324006256 dimer interface [polypeptide binding]; other site 657324006257 putative anticodon binding site; other site 657324006258 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 657324006259 motif 1; other site 657324006260 active site 657324006261 motif 2; other site 657324006262 motif 3; other site 657324006263 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 657324006264 dimer interface [polypeptide binding]; other site 657324006265 putative tRNA-binding site [nucleotide binding]; other site 657324006266 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657324006267 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657324006268 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 657324006269 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 657324006270 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 657324006271 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 657324006272 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 657324006273 FMN binding site [chemical binding]; other site 657324006274 active site 657324006275 catalytic residues [active] 657324006276 substrate binding site [chemical binding]; other site 657324006277 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657324006278 nucleotide binding site [chemical binding]; other site 657324006279 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 657324006280 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 657324006281 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 657324006282 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 657324006283 Bacterial SH3 domain; Region: SH3_3; pfam08239 657324006284 Bacterial SH3 domain; Region: SH3_3; pfam08239 657324006285 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 657324006286 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 657324006287 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 657324006288 active site 657324006289 homodimer interface [polypeptide binding]; other site 657324006290 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 657324006291 HIT family signature motif; other site 657324006292 catalytic residue [active] 657324006293 Rhomboid family; Region: Rhomboid; pfam01694 657324006294 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 657324006295 dihydrodipicolinate synthase; Region: dapA; TIGR00674 657324006296 dimer interface [polypeptide binding]; other site 657324006297 active site 657324006298 catalytic residue [active] 657324006299 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 657324006300 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 657324006301 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657324006302 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657324006303 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 657324006304 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 657324006305 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 657324006306 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657324006307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324006308 ABC transporter signature motif; other site 657324006309 Walker B; other site 657324006310 D-loop; other site 657324006311 H-loop/switch region; other site 657324006312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324006313 Walker A/P-loop; other site 657324006314 ATP binding site [chemical binding]; other site 657324006315 Q-loop/lid; other site 657324006316 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657324006317 HipA-like N-terminal domain; Region: HipA_N; pfam07805 657324006318 HipA-like C-terminal domain; Region: HipA_C; pfam07804 657324006319 HipA N-terminal domain; Region: Couple_hipA; cl11853 657324006320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 657324006321 Putative zinc-finger; Region: zf-HC2; pfam13490 657324006322 Putative zinc-finger; Region: zf-HC2; pfam13490 657324006323 putative acetyltransferase; Provisional; Region: PRK03624 657324006324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324006325 Coenzyme A binding pocket [chemical binding]; other site 657324006326 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 657324006327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657324006328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657324006329 DNA binding residues [nucleotide binding] 657324006330 QueT transporter; Region: QueT; pfam06177 657324006331 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 657324006332 Zn binding site [ion binding]; other site 657324006333 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 657324006334 H+ Antiporter protein; Region: 2A0121; TIGR00900 657324006335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657324006336 putative substrate translocation pore; other site 657324006337 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 657324006338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324006339 Coenzyme A binding pocket [chemical binding]; other site 657324006340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324006341 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 657324006342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 657324006343 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 657324006344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 657324006345 SEC-C motif; Region: SEC-C; pfam02810 657324006346 TadE-like protein; Region: TadE; pfam07811 657324006347 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 657324006348 Type II/IV secretion system protein; Region: T2SE; pfam00437 657324006349 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 657324006350 ATP binding site [chemical binding]; other site 657324006351 Walker A motif; other site 657324006352 hexamer interface [polypeptide binding]; other site 657324006353 Walker B motif; other site 657324006354 Flagellar protein FliS; Region: FliS; cl00654 657324006355 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657324006356 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 657324006357 recombination protein RecR; Reviewed; Region: recR; PRK00076 657324006358 RecR protein; Region: RecR; pfam02132 657324006359 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 657324006360 putative active site [active] 657324006361 putative metal-binding site [ion binding]; other site 657324006362 tetramer interface [polypeptide binding]; other site 657324006363 hypothetical protein; Validated; Region: PRK00153 657324006364 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 657324006365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324006366 Walker A motif; other site 657324006367 ATP binding site [chemical binding]; other site 657324006368 Walker B motif; other site 657324006369 arginine finger; other site 657324006370 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 657324006371 6-phosphofructokinase; Provisional; Region: PRK03202 657324006372 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 657324006373 active site 657324006374 ADP/pyrophosphate binding site [chemical binding]; other site 657324006375 dimerization interface [polypeptide binding]; other site 657324006376 allosteric effector site; other site 657324006377 fructose-1,6-bisphosphate binding site; other site 657324006378 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 657324006379 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 657324006380 metal binding site [ion binding]; metal-binding site 657324006381 dimer interface [polypeptide binding]; other site 657324006382 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 657324006383 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 657324006384 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 657324006385 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 657324006386 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 657324006387 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 657324006388 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 657324006389 gamma subunit interface [polypeptide binding]; other site 657324006390 epsilon subunit interface [polypeptide binding]; other site 657324006391 LBP interface [polypeptide binding]; other site 657324006392 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 657324006393 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 657324006394 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 657324006395 alpha subunit interaction interface [polypeptide binding]; other site 657324006396 Walker A motif; other site 657324006397 ATP binding site [chemical binding]; other site 657324006398 Walker B motif; other site 657324006399 inhibitor binding site; inhibition site 657324006400 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 657324006401 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 657324006402 core domain interface [polypeptide binding]; other site 657324006403 delta subunit interface [polypeptide binding]; other site 657324006404 epsilon subunit interface [polypeptide binding]; other site 657324006405 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 657324006406 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 657324006407 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 657324006408 beta subunit interaction interface [polypeptide binding]; other site 657324006409 Walker A motif; other site 657324006410 ATP binding site [chemical binding]; other site 657324006411 Walker B motif; other site 657324006412 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 657324006413 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 657324006414 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 657324006415 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 657324006416 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 657324006417 catalytic motif [active] 657324006418 Zn binding site [ion binding]; other site 657324006419 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 657324006420 Low molecular weight phosphatase family; Region: LMWPc; cl00105 657324006421 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 657324006422 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 657324006423 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 657324006424 active site 657324006425 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 657324006426 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 657324006427 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 657324006428 4Fe-4S binding domain; Region: Fer4; cl02805 657324006429 replicative DNA helicase; Region: DnaB; TIGR00665 657324006430 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 657324006431 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 657324006432 Walker A motif; other site 657324006433 ATP binding site [chemical binding]; other site 657324006434 Walker B motif; other site 657324006435 DNA binding loops [nucleotide binding] 657324006436 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 657324006437 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 657324006438 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 657324006439 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 657324006440 DHH family; Region: DHH; pfam01368 657324006441 DHHA1 domain; Region: DHHA1; pfam02272 657324006442 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 657324006443 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 657324006444 Walker A/P-loop; other site 657324006445 ATP binding site [chemical binding]; other site 657324006446 Q-loop/lid; other site 657324006447 ABC transporter signature motif; other site 657324006448 Walker B; other site 657324006449 D-loop; other site 657324006450 H-loop/switch region; other site 657324006451 TOBE domain; Region: TOBE; pfam03459 657324006452 galactokinase; Provisional; Region: PRK05322 657324006453 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 657324006454 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 657324006455 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 657324006456 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 657324006457 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 657324006458 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 657324006459 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 657324006460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 657324006461 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 657324006462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324006463 putative PBP binding loops; other site 657324006464 dimer interface [polypeptide binding]; other site 657324006465 ABC-ATPase subunit interface; other site 657324006466 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324006467 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657324006468 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657324006469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324006470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657324006471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324006472 homodimer interface [polypeptide binding]; other site 657324006473 catalytic residue [active] 657324006474 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657324006475 PAS domain S-box; Region: sensory_box; TIGR00229 657324006476 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324006477 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324006478 metal binding site [ion binding]; metal-binding site 657324006479 active site 657324006480 I-site; other site 657324006481 Protein of unknown function DUF111; Region: DUF111; cl03398 657324006482 Protein of unknown function DUF111; Region: DUF111; cl03398 657324006483 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657324006484 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324006485 dimer interface [polypeptide binding]; other site 657324006486 putative CheW interface [polypeptide binding]; other site 657324006487 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 657324006488 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 657324006489 putative ligand binding site [chemical binding]; other site 657324006490 putative NAD binding site [chemical binding]; other site 657324006491 catalytic site [active] 657324006492 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 657324006493 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 657324006494 putative active site; other site 657324006495 catalytic triad [active] 657324006496 putative dimer interface [polypeptide binding]; other site 657324006497 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 657324006498 agmatine deiminase; Region: agmatine_aguA; TIGR03380 657324006499 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 657324006500 spermidine synthase; Provisional; Region: PRK00811 657324006501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324006502 S-adenosylmethionine binding site [chemical binding]; other site 657324006503 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 657324006504 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 657324006505 homodimer interface [polypeptide binding]; other site 657324006506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324006507 catalytic residue [active] 657324006508 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 657324006509 Rubrerythrin [Energy production and conversion]; Region: COG1592 657324006510 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 657324006511 binuclear metal center [ion binding]; other site 657324006512 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 657324006513 iron binding site [ion binding]; other site 657324006514 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 657324006515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324006516 salt bridge; other site 657324006517 non-specific DNA binding site [nucleotide binding]; other site 657324006518 sequence-specific DNA binding site [nucleotide binding]; other site 657324006519 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 657324006520 Part of AAA domain; Region: AAA_19; pfam13245 657324006521 Family description; Region: UvrD_C_2; pfam13538 657324006522 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 657324006523 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 657324006524 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 657324006525 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 657324006526 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 657324006527 putative active site [active] 657324006528 putative metal binding site [ion binding]; other site 657324006529 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 657324006530 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 657324006531 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 657324006532 dimer interface [polypeptide binding]; other site 657324006533 ssDNA binding site [nucleotide binding]; other site 657324006534 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657324006535 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 657324006536 Divergent PAP2 family; Region: DUF212; cl00855 657324006537 Predicted methyltransferases [General function prediction only]; Region: COG0313 657324006538 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 657324006539 putative SAM binding site [chemical binding]; other site 657324006540 putative homodimer interface [polypeptide binding]; other site 657324006541 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 657324006542 Methyltransferase domain; Region: Methyltransf_26; pfam13659 657324006543 PSP1 C-terminal conserved region; Region: PSP1; cl00770 657324006544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324006545 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 657324006546 Walker A motif; other site 657324006547 ATP binding site [chemical binding]; other site 657324006548 Walker B motif; other site 657324006549 arginine finger; other site 657324006550 Protein of unknown function (DUF327); Region: DUF327; pfam03885 657324006551 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657324006552 active site 657324006553 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 657324006554 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 657324006555 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657324006556 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657324006557 catalytic residue [active] 657324006558 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 657324006559 GTP binding site; other site 657324006560 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 657324006561 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 657324006562 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 657324006563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324006564 S-adenosylmethionine binding site [chemical binding]; other site 657324006565 flagellar motor switch protein; Validated; Region: PRK08119 657324006566 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 657324006567 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 657324006568 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 657324006569 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 657324006570 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657324006571 P-loop; other site 657324006572 Magnesium ion binding site [ion binding]; other site 657324006573 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 657324006574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324006575 S-adenosylmethionine binding site [chemical binding]; other site 657324006576 glucose-inhibited division protein A; Region: gidA; TIGR00136 657324006577 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 657324006578 trmE is a tRNA modification GTPase; Region: trmE; cd04164 657324006579 G1 box; other site 657324006580 GTP/Mg2+ binding site [chemical binding]; other site 657324006581 Switch I region; other site 657324006582 G2 box; other site 657324006583 Switch II region; other site 657324006584 G3 box; other site 657324006585 G4 box; other site 657324006586 G5 box; other site 657324006587 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 657324006588 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 657324006589 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 657324006590 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 657324006591 G-X-X-G motif; other site 657324006592 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 657324006593 RxxxH motif; other site 657324006594 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 657324006595 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 657324006596 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 657324006597 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 657324006598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324006599 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657324006600 Walker A motif; other site 657324006601 ATP binding site [chemical binding]; other site 657324006602 Walker B motif; other site 657324006603 arginine finger; other site 657324006604 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 657324006605 DnaA box-binding interface [nucleotide binding]; other site 657324006606 DNA polymerase III subunit beta; Validated; Region: PRK05643 657324006607 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 657324006608 putative DNA binding surface [nucleotide binding]; other site 657324006609 dimer interface [polypeptide binding]; other site 657324006610 beta-clamp/clamp loader binding surface; other site 657324006611 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 657324006612 beta-clamp/translesion DNA polymerase binding surface; other site 657324006613 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657324006614 RNA binding surface [nucleotide binding]; other site 657324006615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324006616 Walker A/P-loop; other site 657324006617 ATP binding site [chemical binding]; other site 657324006618 recombination protein F; Reviewed; Region: recF; PRK00064 657324006619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324006620 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 657324006621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324006622 ABC transporter signature motif; other site 657324006623 Walker B; other site 657324006624 D-loop; other site 657324006625 H-loop/switch region; other site 657324006626 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 657324006627 DNA gyrase subunit A; Validated; Region: PRK05560 657324006628 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 657324006629 CAP-like domain; other site 657324006630 active site 657324006631 primary dimer interface [polypeptide binding]; other site 657324006632 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657324006633 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657324006634 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657324006635 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657324006636 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657324006637 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 657324006638 fumarate hydratase; Provisional; Region: PRK06246 657324006639 Fumarase C-terminus; Region: Fumerase_C; cl00795 657324006640 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 657324006641 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657324006642 Walker A/P-loop; other site 657324006643 ATP binding site [chemical binding]; other site 657324006644 Q-loop/lid; other site 657324006645 ABC transporter signature motif; other site 657324006646 Walker B; other site 657324006647 D-loop; other site 657324006648 H-loop/switch region; other site 657324006649 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 657324006650 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 657324006651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657324006652 Walker A/P-loop; other site 657324006653 ATP binding site [chemical binding]; other site 657324006654 Q-loop/lid; other site 657324006655 ABC transporter signature motif; other site 657324006656 Walker B; other site 657324006657 D-loop; other site 657324006658 H-loop/switch region; other site 657324006659 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 657324006660 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 657324006661 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657324006662 peptide binding site [polypeptide binding]; other site 657324006663 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 657324006664 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 657324006665 active site 657324006666 HIGH motif; other site 657324006667 dimer interface [polypeptide binding]; other site 657324006668 KMSKS motif; other site 657324006669 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657324006670 RNA binding surface [nucleotide binding]; other site 657324006671 PAP2 superfamily; Region: PAP2; pfam01569 657324006672 active site 657324006673 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 657324006674 Domain of unknown function DUF; Region: DUF204; pfam02659 657324006675 Domain of unknown function DUF; Region: DUF204; pfam02659 657324006676 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 657324006677 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 657324006678 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 657324006679 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 657324006680 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 657324006681 active site 657324006682 HIGH motif; other site 657324006683 KMSKS motif; other site 657324006684 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 657324006685 tRNA binding surface [nucleotide binding]; other site 657324006686 anticodon binding site; other site 657324006687 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 657324006688 dimer interface [polypeptide binding]; other site 657324006689 putative tRNA-binding site [nucleotide binding]; other site 657324006690 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 657324006691 active site 657324006692 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 657324006693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324006694 S-adenosylmethionine binding site [chemical binding]; other site 657324006695 TPR repeat; Region: TPR_11; pfam13414 657324006696 Tetratricopeptide repeat; Region: TPR_12; pfam13424 657324006697 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324006698 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324006699 metal binding site [ion binding]; metal-binding site 657324006700 active site 657324006701 I-site; other site 657324006702 Predicted membrane protein [Function unknown]; Region: COG1511 657324006703 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 657324006704 Predicted membrane protein [Function unknown]; Region: COG1511 657324006705 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 657324006706 Predicted membrane protein [Function unknown]; Region: COG1511 657324006707 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 657324006708 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 657324006709 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 657324006710 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 657324006711 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 657324006712 active site 657324006713 catalytic site [active] 657324006714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 657324006715 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 657324006716 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 657324006717 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324006718 FeS/SAM binding site; other site 657324006719 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 657324006720 nucleoside/Zn binding site; other site 657324006721 dimer interface [polypeptide binding]; other site 657324006722 catalytic motif [active] 657324006723 putative hydratase; Provisional; Region: PRK11413 657324006724 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 657324006725 substrate binding site [chemical binding]; other site 657324006726 ligand binding site [chemical binding]; other site 657324006727 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 657324006728 substrate binding site [chemical binding]; other site 657324006729 glycogen branching enzyme; Provisional; Region: PRK12313 657324006730 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 657324006731 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 657324006732 active site 657324006733 catalytic site [active] 657324006734 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 657324006735 Colicin V production protein; Region: Colicin_V; pfam02674 657324006736 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324006737 Zn2+ binding site [ion binding]; other site 657324006738 Mg2+ binding site [ion binding]; other site 657324006739 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657324006740 Walker A motif; other site 657324006741 ATP binding site [chemical binding]; other site 657324006742 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 657324006743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324006744 Walker A motif; other site 657324006745 ATP binding site [chemical binding]; other site 657324006746 Walker B motif; other site 657324006747 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 657324006748 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 657324006749 Clp amino terminal domain; Region: Clp_N; pfam02861 657324006750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657324006751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 657324006752 Walker A motif; other site 657324006753 ATP binding site [chemical binding]; other site 657324006754 Clp amino terminal domain; Region: Clp_N; pfam02861 657324006755 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 657324006756 active site 657324006757 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657324006758 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 657324006759 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 657324006760 catalytic tetrad [active] 657324006761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324006762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324006763 metal binding site [ion binding]; metal-binding site 657324006764 active site 657324006765 I-site; other site 657324006766 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 657324006767 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 657324006768 active site 657324006769 catalytic triad [active] 657324006770 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 657324006771 Catalytic site [active] 657324006772 active site 657324006773 UTP binding site [chemical binding]; other site 657324006774 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 657324006775 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 657324006776 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 657324006777 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 657324006778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 657324006779 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657324006780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 657324006781 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 657324006782 active site 657324006783 catalytic site [active] 657324006784 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 657324006785 heat shock protein 90; Provisional; Region: PRK05218 657324006786 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 657324006787 ATP binding site [chemical binding]; other site 657324006788 Mg2+ binding site [ion binding]; other site 657324006789 G-X-G motif; other site 657324006790 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 657324006791 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 657324006792 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 657324006793 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 657324006794 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 657324006795 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 657324006796 active site 657324006797 6-phosphofructokinase; Provisional; Region: PRK14072 657324006798 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 657324006799 active site 657324006800 ADP/pyrophosphate binding site [chemical binding]; other site 657324006801 dimerization interface [polypeptide binding]; other site 657324006802 allosteric effector site; other site 657324006803 fructose-1,6-bisphosphate binding site; other site 657324006804 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 657324006805 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 657324006806 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 657324006807 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 657324006808 active site 657324006809 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 657324006810 Family of unknown function (DUF633); Region: DUF633; pfam04816 657324006811 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 657324006812 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 657324006813 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657324006814 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 657324006815 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657324006816 DNA binding residues [nucleotide binding] 657324006817 DNA primase; Validated; Region: dnaG; PRK05667 657324006818 CHC2 zinc finger; Region: zf-CHC2; pfam01807 657324006819 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 657324006820 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 657324006821 active site 657324006822 metal binding site [ion binding]; metal-binding site 657324006823 interdomain interaction site; other site 657324006824 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 657324006825 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 657324006826 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 657324006827 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657324006828 Zn2+ binding site [ion binding]; other site 657324006829 Mg2+ binding site [ion binding]; other site 657324006830 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 657324006831 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 657324006832 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 657324006833 NAD binding site [chemical binding]; other site 657324006834 dimer interface [polypeptide binding]; other site 657324006835 substrate binding site [chemical binding]; other site 657324006836 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657324006837 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657324006838 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324006839 metal binding site [ion binding]; metal-binding site 657324006840 active site 657324006841 I-site; other site 657324006842 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657324006843 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 657324006844 active site 657324006845 catalytic triad [active] 657324006846 oxyanion hole [active] 657324006847 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 657324006848 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 657324006849 Carboxylesterase family; Region: COesterase; pfam00135 657324006850 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 657324006851 substrate binding pocket [chemical binding]; other site 657324006852 catalytic triad [active] 657324006853 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 657324006854 putative active site [active] 657324006855 dimerization interface [polypeptide binding]; other site 657324006856 putative tRNAtyr binding site [nucleotide binding]; other site 657324006857 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 657324006858 catalytic triad [active] 657324006859 Phosphopantetheine attachment site; Region: PP-binding; cl09936 657324006860 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 657324006861 CoA binding site [chemical binding]; other site 657324006862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 657324006863 acyl-activating enzyme (AAE) consensus motif; other site 657324006864 active site 657324006865 AMP binding site [chemical binding]; other site 657324006866 CoA binding site [chemical binding]; other site 657324006867 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 657324006868 aspartate racemase; Region: asp_race; TIGR00035 657324006869 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 657324006870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 657324006871 hypothetical protein; Provisional; Region: PRK13663 657324006872 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 657324006873 active site 657324006874 catalytic site [active] 657324006875 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 657324006876 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 657324006877 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 657324006878 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 657324006879 Rhamnan synthesis protein F; Region: RgpF; pfam05045 657324006880 Rhamnan synthesis protein F; Region: RgpF; pfam05045 657324006881 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 657324006882 Rhamnan synthesis protein F; Region: RgpF; pfam05045 657324006883 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657324006884 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657324006885 active site 657324006886 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657324006887 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 657324006888 putative ADP-binding pocket [chemical binding]; other site 657324006889 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 657324006890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657324006891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324006892 non-specific DNA binding site [nucleotide binding]; other site 657324006893 salt bridge; other site 657324006894 sequence-specific DNA binding site [nucleotide binding]; other site 657324006895 Domain of unknown function DUF87; Region: DUF87; pfam01935 657324006896 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 657324006897 MgtC family; Region: MgtC; pfam02308 657324006898 PAS fold; Region: PAS_3; pfam08447 657324006899 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657324006900 metal binding site [ion binding]; metal-binding site 657324006901 active site 657324006902 I-site; other site 657324006903 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657324006904 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 657324006905 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 657324006906 non-heme iron binding site [ion binding]; other site 657324006907 dimer interface [polypeptide binding]; other site 657324006908 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 657324006909 non-heme iron binding site [ion binding]; other site 657324006910 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 657324006911 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 657324006912 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657324006913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324006914 S-adenosylmethionine binding site [chemical binding]; other site 657324006915 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 657324006916 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 657324006917 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657324006918 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 657324006919 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 657324006920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324006921 motif II; other site 657324006922 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 657324006923 conserved cys residue [active] 657324006924 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657324006925 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 657324006926 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 657324006927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657324006928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657324006929 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657324006930 dimerization interface [polypeptide binding]; other site 657324006931 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 657324006932 Beta-lactamase; Region: Beta-lactamase; pfam00144 657324006933 TIGR04076 family protein; Region: TIGR04076 657324006934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 657324006935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324006936 Coenzyme A binding pocket [chemical binding]; other site 657324006937 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 657324006938 nucleotide binding site/active site [active] 657324006939 HIT family signature motif; other site 657324006940 catalytic residue [active] 657324006941 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 657324006942 Beta-lactamase; Region: Beta-lactamase; pfam00144 657324006943 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 657324006944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657324006945 Coenzyme A binding pocket [chemical binding]; other site 657324006946 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 657324006947 metal binding triad [ion binding]; metal-binding site 657324006948 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657324006949 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 657324006950 VanZ like family; Region: VanZ; pfam04892 657324006951 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 657324006952 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657324006953 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 657324006954 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 657324006955 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 657324006956 Predicted amidohydrolase [General function prediction only]; Region: COG0388 657324006957 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 657324006958 active site 657324006959 catalytic triad [active] 657324006960 dimer interface [polypeptide binding]; other site 657324006961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657324006962 NAD(P) binding site [chemical binding]; other site 657324006963 active site 657324006964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324006965 dimer interface [polypeptide binding]; other site 657324006966 putative CheW interface [polypeptide binding]; other site 657324006967 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 657324006968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657324006969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 657324006970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657324006971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657324006972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657324006973 putative DNA binding site [nucleotide binding]; other site 657324006974 putative Zn2+ binding site [ion binding]; other site 657324006975 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 657324006976 AAA domain; Region: AAA_25; pfam13481 657324006977 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657324006978 Walker A motif; other site 657324006979 ATP binding site [chemical binding]; other site 657324006980 Walker B motif; other site 657324006981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324006982 non-specific DNA binding site [nucleotide binding]; other site 657324006983 salt bridge; other site 657324006984 sequence-specific DNA binding site [nucleotide binding]; other site 657324006985 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657324006986 active site 657324006987 Int/Topo IB signature motif; other site 657324006988 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 657324006989 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 657324006990 23S rRNA interface [nucleotide binding]; other site 657324006991 L3 interface [polypeptide binding]; other site 657324006992 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 657324006993 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 657324006994 dimerization interface 3.5A [polypeptide binding]; other site 657324006995 active site 657324006996 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 657324006997 Cobalt transport protein; Region: CbiQ; cl00463 657324006998 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 657324006999 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657324007000 Walker A/P-loop; other site 657324007001 ATP binding site [chemical binding]; other site 657324007002 Q-loop/lid; other site 657324007003 ABC transporter signature motif; other site 657324007004 Walker B; other site 657324007005 D-loop; other site 657324007006 H-loop/switch region; other site 657324007007 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657324007008 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 657324007009 Walker A/P-loop; other site 657324007010 ATP binding site [chemical binding]; other site 657324007011 Q-loop/lid; other site 657324007012 ABC transporter signature motif; other site 657324007013 Walker B; other site 657324007014 D-loop; other site 657324007015 H-loop/switch region; other site 657324007016 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 657324007017 hypothetical protein; Validated; Region: PRK07682 657324007018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657324007019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324007020 homodimer interface [polypeptide binding]; other site 657324007021 catalytic residue [active] 657324007022 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 657324007023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 657324007024 AsnC family; Region: AsnC_trans_reg; pfam01037 657324007025 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 657324007026 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 657324007027 dimerization interface [polypeptide binding]; other site 657324007028 putative ATP binding site [chemical binding]; other site 657324007029 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 657324007030 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 657324007031 Catalytic site [active] 657324007032 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 657324007033 active site 657324007034 catalytic site [active] 657324007035 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 657324007036 metal ion-dependent adhesion site (MIDAS); other site 657324007037 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657324007038 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 657324007039 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 657324007040 active site 657324007041 catalytic site [active] 657324007042 Cna protein B-type domain; Region: Cna_B; pfam05738 657324007043 PA14 domain; Region: PA14; cl08459 657324007044 Cna protein B-type domain; Region: Cna_B; pfam05738 657324007045 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 657324007046 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657324007047 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657324007048 active site 657324007049 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 657324007050 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 657324007051 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 657324007052 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 657324007053 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 657324007054 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 657324007055 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 657324007056 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 657324007057 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 657324007058 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657324007059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657324007060 active site 657324007061 phosphorylation site [posttranslational modification] 657324007062 intermolecular recognition site; other site 657324007063 dimerization interface [polypeptide binding]; other site 657324007064 LytTr DNA-binding domain; Region: LytTR; pfam04397 657324007065 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 657324007066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324007067 S-adenosylmethionine binding site [chemical binding]; other site 657324007068 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 657324007069 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 657324007070 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 657324007071 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 657324007072 active site 657324007073 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 657324007074 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 657324007075 active site 657324007076 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 657324007077 Predicted transcriptional regulator [Transcription]; Region: COG3432 657324007078 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 657324007079 Malic enzyme, N-terminal domain; Region: malic; pfam00390 657324007080 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 657324007081 putative NAD(P) binding site [chemical binding]; other site 657324007082 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 657324007083 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 657324007084 transcription termination factor Rho; Provisional; Region: PRK12608 657324007085 RNA binding site [nucleotide binding]; other site 657324007086 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657324007087 Walker A motif; other site 657324007088 ATP binding site [chemical binding]; other site 657324007089 Walker B motif; other site 657324007090 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 657324007091 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 657324007092 DRTGG domain; Region: DRTGG; pfam07085 657324007093 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 657324007094 DHH family; Region: DHH; pfam01368 657324007095 DHHA2 domain; Region: DHHA2; pfam02833 657324007096 glycyl-tRNA synthetase; Provisional; Region: PRK04173 657324007097 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 657324007098 active site 657324007099 motif 2; other site 657324007100 motif 3; other site 657324007101 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 657324007102 anticodon binding site; other site 657324007103 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 657324007104 Recombination protein O N terminal; Region: RecO_N; pfam11967 657324007105 DNA repair protein RecO; Region: reco; TIGR00613 657324007106 Recombination protein O C terminal; Region: RecO_C; pfam02565 657324007107 GTPase Era; Reviewed; Region: era; PRK00089 657324007108 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 657324007109 G1 box; other site 657324007110 GTP/Mg2+ binding site [chemical binding]; other site 657324007111 Switch I region; other site 657324007112 G2 box; other site 657324007113 Switch II region; other site 657324007114 G3 box; other site 657324007115 G4 box; other site 657324007116 G5 box; other site 657324007117 Uncharacterized conserved protein [Function unknown]; Region: COG4198 657324007118 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 657324007119 glycerate dehydrogenase; Provisional; Region: PRK06436 657324007120 putative ligand binding site [chemical binding]; other site 657324007121 putative NAD binding site [chemical binding]; other site 657324007122 putative catalytic site [active] 657324007123 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 657324007124 L-serine binding site [chemical binding]; other site 657324007125 ACT domain interface; other site 657324007126 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 657324007127 homodimer interface [polypeptide binding]; other site 657324007128 substrate-cofactor binding pocket; other site 657324007129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657324007130 catalytic residue [active] 657324007131 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 657324007132 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 657324007133 PYR/PP interface [polypeptide binding]; other site 657324007134 dimer interface [polypeptide binding]; other site 657324007135 TPP binding site [chemical binding]; other site 657324007136 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 657324007137 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 657324007138 TPP-binding site [chemical binding]; other site 657324007139 dimer interface [polypeptide binding]; other site 657324007140 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 657324007141 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 657324007142 tartrate dehydrogenase; Provisional; Region: PRK08194 657324007143 Biotin operon repressor [Transcription]; Region: BirA; COG1654 657324007144 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 657324007145 Predicted membrane protein [Function unknown]; Region: COG4905 657324007146 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 657324007147 Vacuolar (H+)-ATPase G subunit; Region: V-ATPase_G; cl03922 657324007148 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 657324007149 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 657324007150 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 657324007151 ligand binding site [chemical binding]; other site 657324007152 flexible hinge region; other site 657324007153 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 657324007154 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 657324007155 PAS domain; Region: PAS_10; pfam13596 657324007156 biotin synthase; Region: bioB; TIGR00433 657324007157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657324007158 FeS/SAM binding site; other site 657324007159 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 657324007160 BioY family; Region: BioY; pfam02632 657324007161 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 657324007162 A new structural DNA glycosylase; Region: AlkD_like; cd06561 657324007163 active site 657324007164 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 657324007165 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 657324007166 active site 657324007167 metal binding site [ion binding]; metal-binding site 657324007168 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 657324007169 active site 657324007170 Zn binding site [ion binding]; other site 657324007171 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 657324007172 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 657324007173 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 657324007174 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 657324007175 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 657324007176 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 657324007177 Cell division protein FtsA; Region: FtsA; cl17206 657324007178 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 657324007179 nucleotide binding site [chemical binding]; other site 657324007180 Cell division protein FtsA; Region: FtsA; cl17206 657324007181 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 657324007182 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 657324007183 CoA-binding site [chemical binding]; other site 657324007184 ATP-binding [chemical binding]; other site 657324007185 Protein of unknown function (DUF975); Region: DUF975; cl10504 657324007186 DNA polymerase I; Provisional; Region: PRK05755 657324007187 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 657324007188 active site 657324007189 metal binding site 1 [ion binding]; metal-binding site 657324007190 putative 5' ssDNA interaction site; other site 657324007191 metal binding site 3; metal-binding site 657324007192 metal binding site 2 [ion binding]; metal-binding site 657324007193 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 657324007194 putative DNA binding site [nucleotide binding]; other site 657324007195 putative metal binding site [ion binding]; other site 657324007196 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 657324007197 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 657324007198 active site 657324007199 DNA binding site [nucleotide binding] 657324007200 catalytic site [active] 657324007201 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 657324007202 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 657324007203 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 657324007204 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 657324007205 active site 657324007206 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 657324007207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657324007208 non-specific DNA binding site [nucleotide binding]; other site 657324007209 salt bridge; other site 657324007210 sequence-specific DNA binding site [nucleotide binding]; other site 657324007211 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 657324007212 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 657324007213 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 657324007214 active site 657324007215 ADP/pyrophosphate binding site [chemical binding]; other site 657324007216 allosteric effector site; other site 657324007217 dimerization interface [polypeptide binding]; other site 657324007218 fructose-1,6-bisphosphate binding site; other site 657324007219 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 657324007220 DHH family; Region: DHH; pfam01368 657324007221 DHHA1 domain; Region: DHHA1; pfam02272 657324007222 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 657324007223 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 657324007224 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 657324007225 putative active site [active] 657324007226 putative metal binding site [ion binding]; other site 657324007227 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 657324007228 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 657324007229 fructuronate transporter; Provisional; Region: PRK10034; cl15264 657324007230 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 657324007231 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 657324007232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 657324007233 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 657324007234 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 657324007235 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 657324007236 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 657324007237 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 657324007238 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 657324007239 active site 657324007240 Zn binding site [ion binding]; other site 657324007241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657324007242 dimer interface [polypeptide binding]; other site 657324007243 putative CheW interface [polypeptide binding]; other site 657324007244 FIST N domain; Region: FIST; pfam08495 657324007245 FIST C domain; Region: FIST_C; pfam10442 657324007246 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657324007247 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 657324007248 FtsX-like permease family; Region: FtsX; pfam02687 657324007249 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657324007250 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657324007251 Walker A/P-loop; other site 657324007252 ATP binding site [chemical binding]; other site 657324007253 Q-loop/lid; other site 657324007254 ABC transporter signature motif; other site 657324007255 Walker B; other site 657324007256 D-loop; other site 657324007257 H-loop/switch region; other site 657324007258 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 657324007259 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 657324007260 HlyD family secretion protein; Region: HlyD_3; pfam13437 657324007261 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657324007262 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657324007263 Walker A/P-loop; other site 657324007264 ATP binding site [chemical binding]; other site 657324007265 Q-loop/lid; other site 657324007266 ABC transporter signature motif; other site 657324007267 Walker B; other site 657324007268 D-loop; other site 657324007269 H-loop/switch region; other site 657324007270 Predicted transcriptional regulators [Transcription]; Region: COG1725 657324007271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657324007272 DNA-binding site [nucleotide binding]; DNA binding site 657324007273 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657324007274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324007275 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657324007276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324007277 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657324007278 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657324007279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324007280 dimer interface [polypeptide binding]; other site 657324007281 conserved gate region; other site 657324007282 putative PBP binding loops; other site 657324007283 ABC-ATPase subunit interface; other site 657324007284 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657324007285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657324007286 dimer interface [polypeptide binding]; other site 657324007287 conserved gate region; other site 657324007288 putative PBP binding loops; other site 657324007289 ABC-ATPase subunit interface; other site 657324007290 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 657324007291 substrate binding site [chemical binding]; other site 657324007292 active site 657324007293 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 657324007294 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 657324007295 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 657324007296 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 657324007297 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 657324007298 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 657324007299 active site 657324007300 substrate binding site [chemical binding]; other site 657324007301 cosubstrate binding site; other site 657324007302 catalytic site [active] 657324007303 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 657324007304 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 657324007305 dimerization interface [polypeptide binding]; other site 657324007306 putative ATP binding site [chemical binding]; other site 657324007307 AIR carboxylase; Region: AIRC; pfam00731 657324007308 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 657324007309 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 657324007310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657324007311 active site 657324007312 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 657324007313 Y-family of DNA polymerases; Region: PolY; cl12025 657324007314 active site 657324007315 Y-family of DNA polymerases; Region: PolY; cl12025 657324007316 DNA binding site [nucleotide binding] 657324007317 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 657324007318 Isochorismatase family; Region: Isochorismatase; pfam00857 657324007319 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 657324007320 catalytic triad [active] 657324007321 conserved cis-peptide bond; other site 657324007322 Protein of unknown function (DUF523); Region: DUF523; pfam04463 657324007323 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 657324007324 Fic family protein [Function unknown]; Region: COG3177 657324007325 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 657324007326 Fic/DOC family; Region: Fic; pfam02661 657324007327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 657324007328 DNA-binding site [nucleotide binding]; DNA binding site 657324007329 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 657324007330 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657324007331 active site 657324007332 metal binding site [ion binding]; metal-binding site 657324007333 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 657324007334 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 657324007335 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 657324007336 Proteins of 100 residues with WXG; Region: WXG100; cl02005 657324007337 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657324007338 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 657324007339 metal ion-dependent adhesion site (MIDAS); other site 657324007340 Tetratricopeptide repeat; Region: TPR_16; pfam13432 657324007341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657324007342 binding surface 657324007343 TPR motif; other site 657324007344 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 657324007345 Catalytic domain of Protein Kinases; Region: PKc; cd00180 657324007346 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 657324007347 active site 657324007348 ATP binding site [chemical binding]; other site 657324007349 substrate binding site [chemical binding]; other site 657324007350 activation loop (A-loop); other site 657324007351 WYL domain; Region: WYL; pfam13280 657324007352 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 657324007353 putative FMN binding site [chemical binding]; other site 657324007354 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 657324007355 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 657324007356 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 657324007357 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 657324007358 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 657324007359 MFS/sugar transport protein; Region: MFS_2; pfam13347 657324007360 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 657324007361 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 657324007362 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657324007363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657324007364 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 657324007365 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 657324007366 active site 657324007367 catalytic triad [active] 657324007368 oxyanion hole [active] 657324007369 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 657324007370 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 657324007371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657324007372 S-adenosylmethionine binding site [chemical binding]; other site 657324007373 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657324007374 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 657324007375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324007376 Walker A/P-loop; other site 657324007377 ATP binding site [chemical binding]; other site 657324007378 Q-loop/lid; other site 657324007379 ABC transporter signature motif; other site 657324007380 Walker B; other site 657324007381 D-loop; other site 657324007382 H-loop/switch region; other site 657324007383 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657324007384 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657324007385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657324007386 Walker A/P-loop; other site 657324007387 ATP binding site [chemical binding]; other site 657324007388 Q-loop/lid; other site 657324007389 ABC transporter signature motif; other site 657324007390 Walker B; other site 657324007391 D-loop; other site 657324007392 H-loop/switch region; other site 657324007393 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 657324007394 YibE/F-like protein; Region: YibE_F; cl02259 657324007395 Fn3 associated; Region: Fn3_assoc; pfam13287 657324007396 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 657324007397 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 657324007398 PHP domain; Region: PHP; pfam02811 657324007399 active site 657324007400 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 657324007401 generic binding surface I; other site 657324007402 generic binding surface II; other site 657324007403 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 657324007404 ParB-like nuclease domain; Region: ParBc; pfam02195 657324007405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657324007406 active site 657324007407 motif I; other site 657324007408 motif II; other site 657324007409 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 657324007410 Domain of unknown function DUF20; Region: UPF0118; pfam01594 657324007411 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628