-- dump date 20140619_020149 -- class Genbank::misc_feature -- table misc_feature_note -- id note 515622000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 515622000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 515622000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622000004 Walker A motif; other site 515622000005 ATP binding site [chemical binding]; other site 515622000006 Walker B motif; other site 515622000007 arginine finger; other site 515622000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 515622000009 DnaA box-binding interface [nucleotide binding]; other site 515622000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 515622000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 515622000012 putative DNA binding surface [nucleotide binding]; other site 515622000013 dimer interface [polypeptide binding]; other site 515622000014 beta-clamp/clamp loader binding surface; other site 515622000015 beta-clamp/translesion DNA polymerase binding surface; other site 515622000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515622000017 RNA binding surface [nucleotide binding]; other site 515622000018 recombination protein F; Reviewed; Region: recF; PRK00064 515622000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 515622000020 Walker A/P-loop; other site 515622000021 ATP binding site [chemical binding]; other site 515622000022 Q-loop/lid; other site 515622000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622000024 ABC transporter signature motif; other site 515622000025 Walker B; other site 515622000026 D-loop; other site 515622000027 H-loop/switch region; other site 515622000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 515622000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622000030 Mg2+ binding site [ion binding]; other site 515622000031 G-X-G motif; other site 515622000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 515622000033 anchoring element; other site 515622000034 dimer interface [polypeptide binding]; other site 515622000035 ATP binding site [chemical binding]; other site 515622000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 515622000037 active site 515622000038 putative metal-binding site [ion binding]; other site 515622000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 515622000040 DNA gyrase subunit A; Validated; Region: PRK05560 515622000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 515622000042 CAP-like domain; other site 515622000043 active site 515622000044 primary dimer interface [polypeptide binding]; other site 515622000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515622000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515622000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515622000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515622000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515622000050 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622000051 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622000052 metal binding site [ion binding]; metal-binding site 515622000053 active site 515622000054 I-site; other site 515622000055 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 515622000056 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 515622000057 substrate binding site [chemical binding]; other site 515622000058 active site 515622000059 catalytic residues [active] 515622000060 heterodimer interface [polypeptide binding]; other site 515622000061 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 515622000062 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 515622000063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622000064 catalytic residue [active] 515622000065 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 515622000066 active site 515622000067 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 515622000068 active site 515622000069 ribulose/triose binding site [chemical binding]; other site 515622000070 phosphate binding site [ion binding]; other site 515622000071 substrate (anthranilate) binding pocket [chemical binding]; other site 515622000072 product (indole) binding pocket [chemical binding]; other site 515622000073 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 515622000074 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 515622000075 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 515622000076 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622000077 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622000078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622000079 Walker A/P-loop; other site 515622000080 ATP binding site [chemical binding]; other site 515622000081 Q-loop/lid; other site 515622000082 ABC transporter signature motif; other site 515622000083 Walker B; other site 515622000084 D-loop; other site 515622000085 H-loop/switch region; other site 515622000086 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622000087 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622000088 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 515622000089 Walker A/P-loop; other site 515622000090 ATP binding site [chemical binding]; other site 515622000091 Q-loop/lid; other site 515622000092 ABC transporter signature motif; other site 515622000093 Walker B; other site 515622000094 D-loop; other site 515622000095 H-loop/switch region; other site 515622000096 Predicted permeases [General function prediction only]; Region: COG0679 515622000097 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 515622000098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 515622000099 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 515622000100 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 515622000101 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 515622000102 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 515622000103 Double zinc ribbon; Region: DZR; pfam12773 515622000104 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 515622000105 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622000106 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 515622000107 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 515622000108 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 515622000109 active site 515622000110 catalytic tetrad [active] 515622000111 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 515622000112 DNA polymerase IV; Reviewed; Region: PRK03103 515622000113 Y-family of DNA polymerases; Region: PolY; cl12025 515622000114 active site 515622000115 DNA binding site [nucleotide binding] 515622000116 Survival protein SurE; Region: SurE; cl00448 515622000117 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 515622000118 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 515622000119 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 515622000120 putative active site [active] 515622000121 putative metal binding site [ion binding]; other site 515622000122 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 515622000123 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 515622000124 Ca binding site [ion binding]; other site 515622000125 carbohydrate binding site [chemical binding]; other site 515622000126 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622000127 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622000128 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 515622000129 TSCPD domain; Region: TSCPD; cl14834 515622000130 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 515622000131 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 515622000132 active site 515622000133 homodimer interface [polypeptide binding]; other site 515622000134 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 515622000135 Rubredoxin; Region: Rubredoxin; pfam00301 515622000136 iron binding site [ion binding]; other site 515622000137 Rubrerythrin [Energy production and conversion]; Region: COG1592 515622000138 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 515622000139 diiron binding motif [ion binding]; other site 515622000140 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 515622000141 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 515622000142 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 515622000143 putative active site [active] 515622000144 S-ribosylhomocysteinase; Provisional; Region: PRK02260 515622000145 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 515622000146 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 515622000147 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 515622000148 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 515622000149 active site 515622000150 dimer interface [polypeptide binding]; other site 515622000151 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 515622000152 dimer interface [polypeptide binding]; other site 515622000153 active site 515622000154 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 515622000155 active site 515622000156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622000157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622000158 dimerization interface [polypeptide binding]; other site 515622000159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622000160 dimer interface [polypeptide binding]; other site 515622000161 phosphorylation site [posttranslational modification] 515622000162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622000163 ATP binding site [chemical binding]; other site 515622000164 Mg2+ binding site [ion binding]; other site 515622000165 G-X-G motif; other site 515622000166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622000167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622000168 active site 515622000169 phosphorylation site [posttranslational modification] 515622000170 intermolecular recognition site; other site 515622000171 dimerization interface [polypeptide binding]; other site 515622000172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622000173 DNA binding site [nucleotide binding] 515622000174 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 515622000175 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 515622000176 active site 515622000177 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 515622000178 putative metal binding residues [ion binding]; other site 515622000179 signature motif; other site 515622000180 dimer interface [polypeptide binding]; other site 515622000181 active site 515622000182 polyP binding site; other site 515622000183 substrate binding site [chemical binding]; other site 515622000184 acceptor-phosphate pocket; other site 515622000185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622000186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622000187 dimer interface [polypeptide binding]; other site 515622000188 phosphorylation site [posttranslational modification] 515622000189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622000190 ATP binding site [chemical binding]; other site 515622000191 Mg2+ binding site [ion binding]; other site 515622000192 G-X-G motif; other site 515622000193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622000194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622000195 active site 515622000196 phosphorylation site [posttranslational modification] 515622000197 intermolecular recognition site; other site 515622000198 dimerization interface [polypeptide binding]; other site 515622000199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622000200 DNA binding site [nucleotide binding] 515622000201 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 515622000202 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 515622000203 metal binding site 2 [ion binding]; metal-binding site 515622000204 putative DNA binding helix; other site 515622000205 metal binding site 1 [ion binding]; metal-binding site 515622000206 dimer interface [polypeptide binding]; other site 515622000207 structural Zn2+ binding site [ion binding]; other site 515622000208 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 515622000209 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 515622000210 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 515622000211 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 515622000212 Walker A/P-loop; other site 515622000213 ATP binding site [chemical binding]; other site 515622000214 Q-loop/lid; other site 515622000215 ABC transporter signature motif; other site 515622000216 Walker B; other site 515622000217 D-loop; other site 515622000218 H-loop/switch region; other site 515622000219 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 515622000220 FeS assembly protein SufB; Region: sufB; TIGR01980 515622000221 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 515622000222 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 515622000223 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 515622000224 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 515622000225 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515622000226 catalytic residue [active] 515622000227 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 515622000228 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 515622000229 trimerization site [polypeptide binding]; other site 515622000230 active site 515622000231 Protein of unknown function DUF45; Region: DUF45; pfam01863 515622000232 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 515622000233 active site 515622000234 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 515622000235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622000236 S-adenosylmethionine binding site [chemical binding]; other site 515622000237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622000238 binding surface 515622000239 TPR motif; other site 515622000240 glycogen branching enzyme; Provisional; Region: PRK12313 515622000241 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 515622000242 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 515622000243 active site 515622000244 catalytic site [active] 515622000245 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 515622000246 flagellin; Reviewed; Region: PRK08869 515622000247 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 515622000248 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 515622000249 Flagellar protein FliS; Region: FliS; cl00654 515622000250 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 515622000251 AAA domain; Region: AAA_31; pfam13614 515622000252 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 515622000253 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 515622000254 ATP binding site [chemical binding]; other site 515622000255 Walker A motif; other site 515622000256 hexamer interface [polypeptide binding]; other site 515622000257 Walker B motif; other site 515622000258 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 515622000259 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 515622000260 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 515622000261 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 515622000262 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 515622000263 phosphopeptide binding site; other site 515622000264 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 515622000265 SCP-2 sterol transfer family; Region: SCP2; pfam02036 515622000266 Rhomboid family; Region: Rhomboid; pfam01694 515622000267 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 515622000268 HIT family signature motif; other site 515622000269 catalytic residue [active] 515622000270 fumarate hydratase; Provisional; Region: PRK06246 515622000271 Fumarase C-terminus; Region: Fumerase_C; cl00795 515622000272 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622000273 Zn2+ binding site [ion binding]; other site 515622000274 Mg2+ binding site [ion binding]; other site 515622000275 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 515622000276 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 515622000277 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515622000278 catalytic residue [active] 515622000279 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 515622000280 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 515622000281 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 515622000282 domain interfaces; other site 515622000283 active site 515622000284 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 515622000285 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 515622000286 active site 515622000287 Protein of unknown function (DUF327); Region: DUF327; pfam03885 515622000288 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 515622000289 DNA polymerase III subunit delta'; Validated; Region: PRK08485 515622000290 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 515622000291 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 515622000292 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 515622000293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622000294 S-adenosylmethionine binding site [chemical binding]; other site 515622000295 Predicted methyltransferases [General function prediction only]; Region: COG0313 515622000296 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 515622000297 putative SAM binding site [chemical binding]; other site 515622000298 putative homodimer interface [polypeptide binding]; other site 515622000299 alpha-galactosidase; Region: PLN02808; cl17638 515622000300 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 515622000301 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 515622000302 active site 515622000303 substrate-binding site [chemical binding]; other site 515622000304 metal-binding site [ion binding] 515622000305 ATP binding site [chemical binding]; other site 515622000306 CTP synthetase; Validated; Region: pyrG; PRK05380 515622000307 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 515622000308 Catalytic site [active] 515622000309 active site 515622000310 UTP binding site [chemical binding]; other site 515622000311 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 515622000312 active site 515622000313 putative oxyanion hole; other site 515622000314 catalytic triad [active] 515622000315 FtsH Extracellular; Region: FtsH_ext; pfam06480 515622000316 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 515622000317 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 515622000318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622000319 Walker A motif; other site 515622000320 ATP binding site [chemical binding]; other site 515622000321 Walker B motif; other site 515622000322 arginine finger; other site 515622000323 Peptidase family M41; Region: Peptidase_M41; pfam01434 515622000324 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 515622000325 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 515622000326 GIY-YIG motif/motif A; other site 515622000327 active site 515622000328 catalytic site [active] 515622000329 putative DNA binding site [nucleotide binding]; other site 515622000330 metal binding site [ion binding]; metal-binding site 515622000331 UvrB/uvrC motif; Region: UVR; pfam02151 515622000332 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 515622000333 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 515622000334 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 515622000335 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 515622000336 metal ion-dependent adhesion site (MIDAS); other site 515622000337 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 515622000338 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 515622000339 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 515622000340 Hpr binding site; other site 515622000341 active site 515622000342 homohexamer subunit interaction site [polypeptide binding]; other site 515622000343 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 515622000344 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515622000345 nucleotide binding site [chemical binding]; other site 515622000346 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 515622000347 FAD binding domain; Region: FAD_binding_4; pfam01565 515622000348 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 515622000349 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 515622000350 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 515622000351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 515622000352 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 515622000353 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 515622000354 dimerization domain swap beta strand [polypeptide binding]; other site 515622000355 regulatory protein interface [polypeptide binding]; other site 515622000356 active site 515622000357 regulatory phosphorylation site [posttranslational modification]; other site 515622000358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622000359 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622000360 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 515622000361 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 515622000362 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 515622000363 PhoU domain; Region: PhoU; pfam01895 515622000364 PhoU domain; Region: PhoU; pfam01895 515622000365 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 515622000366 Beta-lactamase; Region: Beta-lactamase; pfam00144 515622000367 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 515622000368 dimer interface [polypeptide binding]; other site 515622000369 ADP-ribose binding site [chemical binding]; other site 515622000370 active site 515622000371 nudix motif; other site 515622000372 metal binding site [ion binding]; metal-binding site 515622000373 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 515622000374 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 515622000375 ligand binding site [chemical binding]; other site 515622000376 flexible hinge region; other site 515622000377 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 515622000378 putative switch regulator; other site 515622000379 non-specific DNA interactions [nucleotide binding]; other site 515622000380 DNA binding site [nucleotide binding] 515622000381 sequence specific DNA binding site [nucleotide binding]; other site 515622000382 putative cAMP binding site [chemical binding]; other site 515622000383 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 515622000384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622000385 FeS/SAM binding site; other site 515622000386 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 515622000387 Pyruvate formate lyase 1; Region: PFL1; cd01678 515622000388 coenzyme A binding site [chemical binding]; other site 515622000389 active site 515622000390 catalytic residues [active] 515622000391 glycine loop; other site 515622000392 Right handed beta helix region; Region: Beta_helix; pfam13229 515622000393 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622000394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622000395 DNA binding site [nucleotide binding] 515622000396 domain linker motif; other site 515622000397 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622000398 dimerization interface [polypeptide binding]; other site 515622000399 ligand binding site [chemical binding]; other site 515622000400 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622000401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622000402 dimer interface [polypeptide binding]; other site 515622000403 conserved gate region; other site 515622000404 ABC-ATPase subunit interface; other site 515622000405 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622000406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622000407 dimer interface [polypeptide binding]; other site 515622000408 conserved gate region; other site 515622000409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 515622000410 ABC-ATPase subunit interface; other site 515622000411 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622000412 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622000413 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 515622000414 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 515622000415 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 515622000416 Nitrogen regulatory protein P-II; Region: P-II; smart00938 515622000417 asparagine synthetase B; Provisional; Region: asnB; PRK09431 515622000418 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 515622000419 dimer interface [polypeptide binding]; other site 515622000420 active site 515622000421 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622000422 Ligand Binding Site [chemical binding]; other site 515622000423 Molecular Tunnel; other site 515622000424 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 515622000425 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 515622000426 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 515622000427 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 515622000428 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 515622000429 active site 515622000430 dimer interface [polypeptide binding]; other site 515622000431 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 515622000432 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 515622000433 active site 515622000434 FMN binding site [chemical binding]; other site 515622000435 substrate binding site [chemical binding]; other site 515622000436 3Fe-4S cluster binding site [ion binding]; other site 515622000437 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 515622000438 domain interface; other site 515622000439 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 515622000440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515622000441 Helix-turn-helix domain; Region: HTH_17; pfam12728 515622000442 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 515622000443 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 515622000444 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 515622000445 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 515622000446 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 515622000447 PHP domain; Region: PHP; pfam02811 515622000448 active site 515622000449 fructuronate transporter; Provisional; Region: PRK10034; cl15264 515622000450 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 515622000451 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 515622000452 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 515622000453 MOFRL family; Region: MOFRL; pfam05161 515622000454 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 515622000455 MraW methylase family; Region: Methyltransf_5; cl17771 515622000456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622000457 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622000458 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 515622000459 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 515622000460 Ca binding site [ion binding]; other site 515622000461 active site 515622000462 catalytic site [active] 515622000463 Cache domain; Region: Cache_1; pfam02743 515622000464 HAMP domain; Region: HAMP; pfam00672 515622000465 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622000466 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622000467 dimer interface [polypeptide binding]; other site 515622000468 putative CheW interface [polypeptide binding]; other site 515622000469 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 515622000470 MgtE intracellular N domain; Region: MgtE_N; pfam03448 515622000471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 515622000472 Divalent cation transporter; Region: MgtE; pfam01769 515622000473 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515622000474 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515622000475 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 515622000476 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515622000477 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 515622000478 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 515622000479 dimer interface [polypeptide binding]; other site 515622000480 anticodon binding site; other site 515622000481 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 515622000482 homodimer interface [polypeptide binding]; other site 515622000483 motif 1; other site 515622000484 active site 515622000485 motif 2; other site 515622000486 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 515622000487 active site 515622000488 motif 3; other site 515622000489 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622000490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622000491 non-specific DNA binding site [nucleotide binding]; other site 515622000492 salt bridge; other site 515622000493 sequence-specific DNA binding site [nucleotide binding]; other site 515622000494 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 515622000495 active site 515622000496 catalytic site [active] 515622000497 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 515622000498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622000499 motif II; other site 515622000500 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 515622000501 Ligand binding site; other site 515622000502 Cupin domain; Region: Cupin_2; cl17218 515622000503 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 515622000504 Ligand binding site; other site 515622000505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622000506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622000507 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 515622000508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622000509 active site 515622000510 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 515622000511 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 515622000512 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 515622000513 NADP-binding site; other site 515622000514 homotetramer interface [polypeptide binding]; other site 515622000515 substrate binding site [chemical binding]; other site 515622000516 homodimer interface [polypeptide binding]; other site 515622000517 active site 515622000518 phosphodiesterase; Provisional; Region: PRK12704 515622000519 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 515622000520 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 515622000521 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 515622000522 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 515622000523 Walker A/P-loop; other site 515622000524 ATP binding site [chemical binding]; other site 515622000525 Q-loop/lid; other site 515622000526 ABC transporter signature motif; other site 515622000527 Walker B; other site 515622000528 D-loop; other site 515622000529 H-loop/switch region; other site 515622000530 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622000531 Transposase IS200 like; Region: Y1_Tnp; pfam01797 515622000532 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 515622000533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622000534 AAA domain; Region: AAA_14; pfam13173 515622000535 AAA domain; Region: AAA_22; pfam13401 515622000536 Walker A/P-loop; other site 515622000537 ATP binding site [chemical binding]; other site 515622000538 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 515622000539 Ovarian carcinoma immunoreactive antigen (OCIA); Region: OCIA; pfam07051 515622000540 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 515622000541 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 515622000542 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 515622000543 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 515622000544 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 515622000545 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 515622000546 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 515622000547 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 515622000548 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 515622000549 beta subunit interaction interface [polypeptide binding]; other site 515622000550 Walker A motif; other site 515622000551 ATP binding site [chemical binding]; other site 515622000552 Walker B motif; other site 515622000553 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 515622000554 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 515622000555 core domain interface [polypeptide binding]; other site 515622000556 delta subunit interface [polypeptide binding]; other site 515622000557 epsilon subunit interface [polypeptide binding]; other site 515622000558 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 515622000559 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 515622000560 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 515622000561 alpha subunit interaction interface [polypeptide binding]; other site 515622000562 Walker A motif; other site 515622000563 ATP binding site [chemical binding]; other site 515622000564 Walker B motif; other site 515622000565 inhibitor binding site; inhibition site 515622000566 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 515622000567 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 515622000568 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 515622000569 gamma subunit interface [polypeptide binding]; other site 515622000570 epsilon subunit interface [polypeptide binding]; other site 515622000571 LBP interface [polypeptide binding]; other site 515622000572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622000573 Zn2+ binding site [ion binding]; other site 515622000574 Mg2+ binding site [ion binding]; other site 515622000575 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 515622000576 CNH domain; Region: CNH; cl02434 515622000577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622000578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622000579 dimer interface [polypeptide binding]; other site 515622000580 phosphorylation site [posttranslational modification] 515622000581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622000582 ATP binding site [chemical binding]; other site 515622000583 Mg2+ binding site [ion binding]; other site 515622000584 G-X-G motif; other site 515622000585 Response regulator receiver domain; Region: Response_reg; pfam00072 515622000586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622000587 active site 515622000588 phosphorylation site [posttranslational modification] 515622000589 intermolecular recognition site; other site 515622000590 dimerization interface [polypeptide binding]; other site 515622000591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622000592 Zn2+ binding site [ion binding]; other site 515622000593 Mg2+ binding site [ion binding]; other site 515622000594 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 515622000595 N- and C-terminal domain interface [polypeptide binding]; other site 515622000596 D-xylulose kinase; Region: XylB; TIGR01312 515622000597 active site 515622000598 MgATP binding site [chemical binding]; other site 515622000599 catalytic site [active] 515622000600 metal binding site [ion binding]; metal-binding site 515622000601 xylulose binding site [chemical binding]; other site 515622000602 homodimer interface [polypeptide binding]; other site 515622000603 Domain of unknown function (DUF303); Region: DUF303; pfam03629 515622000604 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515622000605 Domain of unknown function (DUF303); Region: DUF303; pfam03629 515622000606 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515622000607 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515622000608 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515622000609 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 515622000610 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 515622000611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622000612 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622000613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622000614 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 515622000615 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 515622000616 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 515622000617 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 515622000618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622000619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622000620 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622000621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622000622 ABC-ATPase subunit interface; other site 515622000623 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622000624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622000625 dimer interface [polypeptide binding]; other site 515622000626 conserved gate region; other site 515622000627 putative PBP binding loops; other site 515622000628 ABC-ATPase subunit interface; other site 515622000629 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622000630 Transposase IS200 like; Region: Y1_Tnp; pfam01797 515622000631 Probable beta-xylosidase; Provisional; Region: PLN03080 515622000632 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 515622000633 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515622000634 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 515622000635 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 515622000636 hexamer (dimer of trimers) interface [polypeptide binding]; other site 515622000637 trimer interface [polypeptide binding]; other site 515622000638 substrate binding site [chemical binding]; other site 515622000639 Mn binding site [ion binding]; other site 515622000640 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 515622000641 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 515622000642 putative ligand binding site [chemical binding]; other site 515622000643 putative NAD binding site [chemical binding]; other site 515622000644 catalytic site [active] 515622000645 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 515622000646 Transposase IS200 like; Region: Y1_Tnp; pfam01797 515622000647 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 515622000648 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 515622000649 active site 515622000650 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622000651 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622000652 active site 515622000653 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 515622000654 UDP-glucose 4-epimerase; Region: PLN02240 515622000655 NAD binding site [chemical binding]; other site 515622000656 homodimer interface [polypeptide binding]; other site 515622000657 active site 515622000658 substrate binding site [chemical binding]; other site 515622000659 putative hydrolase; Validated; Region: PRK09248 515622000660 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 515622000661 active site 515622000662 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 515622000663 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 515622000664 protein binding site [polypeptide binding]; other site 515622000665 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 515622000666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622000667 Walker A motif; other site 515622000668 ATP binding site [chemical binding]; other site 515622000669 Walker B motif; other site 515622000670 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 515622000671 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 515622000672 carbamate kinase; Reviewed; Region: PRK12686 515622000673 putative substrate binding site [chemical binding]; other site 515622000674 nucleotide binding site [chemical binding]; other site 515622000675 nucleotide binding site [chemical binding]; other site 515622000676 homodimer interface [polypeptide binding]; other site 515622000677 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622000678 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 515622000679 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515622000680 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515622000681 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515622000682 Protein of unknown function (DUF975); Region: DUF975; cl10504 515622000683 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 515622000684 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 515622000685 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 515622000686 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 515622000687 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 515622000688 RNA binding site [nucleotide binding]; other site 515622000689 alpha-galactosidase; Region: PLN02808; cl17638 515622000690 alpha-galactosidase; Region: PLN02808; cl17638 515622000691 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 515622000692 transmembrane helices; other site 515622000693 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622000694 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622000695 metal binding site [ion binding]; metal-binding site 515622000696 active site 515622000697 I-site; other site 515622000698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622000699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622000700 metal binding site [ion binding]; metal-binding site 515622000701 active site 515622000702 I-site; other site 515622000703 Repair protein; Region: Repair_PSII; pfam04536 515622000704 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 515622000705 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 515622000706 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 515622000707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 515622000708 catalytic loop [active] 515622000709 iron binding site [ion binding]; other site 515622000710 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 515622000711 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 515622000712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622000713 Walker A/P-loop; other site 515622000714 ATP binding site [chemical binding]; other site 515622000715 Q-loop/lid; other site 515622000716 ABC transporter signature motif; other site 515622000717 Walker B; other site 515622000718 D-loop; other site 515622000719 H-loop/switch region; other site 515622000720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 515622000721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622000722 ABC-ATPase subunit interface; other site 515622000723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622000724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622000725 dimer interface [polypeptide binding]; other site 515622000726 conserved gate region; other site 515622000727 putative PBP binding loops; other site 515622000728 ABC-ATPase subunit interface; other site 515622000729 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622000730 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622000731 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 515622000732 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 515622000733 dimer interface [polypeptide binding]; other site 515622000734 ADP-ribose binding site [chemical binding]; other site 515622000735 active site 515622000736 nudix motif; other site 515622000737 metal binding site [ion binding]; metal-binding site 515622000738 Response regulator receiver domain; Region: Response_reg; pfam00072 515622000739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622000740 active site 515622000741 phosphorylation site [posttranslational modification] 515622000742 intermolecular recognition site; other site 515622000743 dimerization interface [polypeptide binding]; other site 515622000744 LytTr DNA-binding domain; Region: LytTR; smart00850 515622000745 6-phosphofructokinase; Provisional; Region: PRK03202 515622000746 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 515622000747 active site 515622000748 ADP/pyrophosphate binding site [chemical binding]; other site 515622000749 dimerization interface [polypeptide binding]; other site 515622000750 allosteric effector site; other site 515622000751 fructose-1,6-bisphosphate binding site; other site 515622000752 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 515622000753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622000754 Walker A motif; other site 515622000755 ATP binding site [chemical binding]; other site 515622000756 Walker B motif; other site 515622000757 arginine finger; other site 515622000758 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 515622000759 hypothetical protein; Validated; Region: PRK00153 515622000760 recombination protein RecR; Reviewed; Region: recR; PRK00076 515622000761 RecR protein; Region: RecR; pfam02132 515622000762 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 515622000763 putative active site [active] 515622000764 putative metal-binding site [ion binding]; other site 515622000765 tetramer interface [polypeptide binding]; other site 515622000766 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 515622000767 active site 515622000768 catalytic residues [active] 515622000769 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 515622000770 RNA binding site [nucleotide binding]; other site 515622000771 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 515622000772 RNA binding site [nucleotide binding]; other site 515622000773 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 515622000774 RNA binding site [nucleotide binding]; other site 515622000775 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 515622000776 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 515622000777 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 515622000778 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 515622000779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622000780 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622000781 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622000782 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622000783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622000784 dimer interface [polypeptide binding]; other site 515622000785 conserved gate region; other site 515622000786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 515622000787 ABC-ATPase subunit interface; other site 515622000788 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622000789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622000790 dimer interface [polypeptide binding]; other site 515622000791 conserved gate region; other site 515622000792 ABC-ATPase subunit interface; other site 515622000793 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622000794 NAD-dependent deacetylase; Provisional; Region: PRK00481 515622000795 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 515622000796 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 515622000797 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 515622000798 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 515622000799 dimer interface [polypeptide binding]; other site 515622000800 ssDNA binding site [nucleotide binding]; other site 515622000801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 515622000802 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 515622000803 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 515622000804 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 515622000805 putative dimer interface [polypeptide binding]; other site 515622000806 Predicted integral membrane protein [Function unknown]; Region: COG5505 515622000807 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 515622000808 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 515622000809 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 515622000810 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 515622000811 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622000812 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 515622000813 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 515622000814 substrate binding site [chemical binding]; other site 515622000815 active site 515622000816 cosubstrate binding site; other site 515622000817 catalytic site [active] 515622000818 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 515622000819 anti sigma factor interaction site; other site 515622000820 regulatory phosphorylation site [posttranslational modification]; other site 515622000821 Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172 515622000822 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 515622000823 acyl carrier protein; Provisional; Region: acpP; PRK00982 515622000824 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 515622000825 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 515622000826 acyl-activating enzyme (AAE) consensus motif; other site 515622000827 AMP binding site [chemical binding]; other site 515622000828 active site 515622000829 CoA binding site [chemical binding]; other site 515622000830 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 515622000831 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622000832 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 515622000833 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 515622000834 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 515622000835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 515622000836 acyl-activating enzyme (AAE) consensus motif; other site 515622000837 acyl-activating enzyme (AAE) consensus motif; other site 515622000838 AMP binding site [chemical binding]; other site 515622000839 active site 515622000840 active site 515622000841 AMP binding site [chemical binding]; other site 515622000842 CoA binding site [chemical binding]; other site 515622000843 CoA binding site [chemical binding]; other site 515622000844 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 515622000845 Beta-lactamase; Region: Beta-lactamase; pfam00144 515622000846 Condensation domain; Region: Condensation; pfam00668 515622000847 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 515622000848 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 515622000849 acyl-activating enzyme (AAE) consensus motif; other site 515622000850 AMP binding site [chemical binding]; other site 515622000851 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 515622000852 Condensation domain; Region: Condensation; pfam00668 515622000853 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 515622000854 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 515622000855 acyl-activating enzyme (AAE) consensus motif; other site 515622000856 AMP binding site [chemical binding]; other site 515622000857 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 515622000858 Condensation domain; Region: Condensation; pfam00668 515622000859 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 515622000860 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 515622000861 acyl-activating enzyme (AAE) consensus motif; other site 515622000862 AMP binding site [chemical binding]; other site 515622000863 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 515622000864 Condensation domain; Region: Condensation; pfam00668 515622000865 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 515622000866 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 515622000867 acyl-activating enzyme (AAE) consensus motif; other site 515622000868 AMP binding site [chemical binding]; other site 515622000869 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 515622000870 Condensation domain; Region: Condensation; pfam00668 515622000871 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 515622000872 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 515622000873 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 515622000874 acyl-activating enzyme (AAE) consensus motif; other site 515622000875 AMP binding site [chemical binding]; other site 515622000876 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 515622000877 Condensation domain; Region: Condensation; pfam00668 515622000878 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 515622000879 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 515622000880 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 515622000881 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 515622000882 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 515622000883 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 515622000884 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 515622000885 substrate binding pocket [chemical binding]; other site 515622000886 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 515622000887 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 515622000888 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 515622000889 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 515622000890 anti sigma factor interaction site; other site 515622000891 regulatory phosphorylation site [posttranslational modification]; other site 515622000892 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 515622000893 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 515622000894 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 515622000895 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 515622000896 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 515622000897 active site 515622000898 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 515622000899 generic binding surface II; other site 515622000900 generic binding surface I; other site 515622000901 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622000902 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622000903 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622000904 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 515622000905 DHH family; Region: DHH; pfam01368 515622000906 DHHA1 domain; Region: DHHA1; pfam02272 515622000907 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 515622000908 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 515622000909 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 515622000910 replicative DNA helicase; Region: DnaB; TIGR00665 515622000911 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 515622000912 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 515622000913 Walker A motif; other site 515622000914 ATP binding site [chemical binding]; other site 515622000915 Walker B motif; other site 515622000916 DNA binding loops [nucleotide binding] 515622000917 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 515622000918 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 515622000919 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 515622000920 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 515622000921 dimer interface [polypeptide binding]; other site 515622000922 PYR/PP interface [polypeptide binding]; other site 515622000923 TPP binding site [chemical binding]; other site 515622000924 substrate binding site [chemical binding]; other site 515622000925 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 515622000926 Domain of unknown function; Region: EKR; cl11037 515622000927 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 515622000928 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 515622000929 TPP-binding site [chemical binding]; other site 515622000930 dimer interface [polypeptide binding]; other site 515622000931 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 515622000932 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 515622000933 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 515622000934 Glyco_18 domain; Region: Glyco_18; smart00636 515622000935 active site 515622000936 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 515622000937 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 515622000938 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 515622000939 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622000940 active site 515622000941 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 515622000942 catalytic motif [active] 515622000943 Zn binding site [ion binding]; other site 515622000944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 515622000945 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 515622000946 Protein of unknown function (DUF402); Region: DUF402; pfam04167 515622000947 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 515622000948 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515622000949 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515622000950 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515622000951 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 515622000952 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 515622000953 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 515622000954 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 515622000955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622000956 motif II; other site 515622000957 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 515622000958 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 515622000959 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622000960 active site 515622000961 DNA replication protein DnaC; Validated; Region: PRK06835 515622000962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622000963 Walker A motif; other site 515622000964 ATP binding site [chemical binding]; other site 515622000965 Walker B motif; other site 515622000966 arginine finger; other site 515622000967 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 515622000968 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 515622000969 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 515622000970 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 515622000971 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515622000972 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515622000973 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 515622000974 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 515622000975 ligand binding site; other site 515622000976 oligomer interface; other site 515622000977 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 515622000978 dimer interface [polypeptide binding]; other site 515622000979 N-terminal domain interface [polypeptide binding]; other site 515622000980 sulfate 1 binding site; other site 515622000981 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 515622000982 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 515622000983 ligand binding site; other site 515622000984 oligomer interface; other site 515622000985 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 515622000986 dimer interface [polypeptide binding]; other site 515622000987 N-terminal domain interface [polypeptide binding]; other site 515622000988 sulfate 1 binding site; other site 515622000989 regulatory protein SpoVG; Reviewed; Region: PRK13259 515622000990 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 515622000991 putative active site [active] 515622000992 catalytic residue [active] 515622000993 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 515622000994 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 515622000995 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515622000996 ATP binding site [chemical binding]; other site 515622000997 putative Mg++ binding site [ion binding]; other site 515622000998 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515622000999 nucleotide binding region [chemical binding]; other site 515622001000 ATP-binding site [chemical binding]; other site 515622001001 TRCF domain; Region: TRCF; pfam03461 515622001002 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 515622001003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622001004 motif II; other site 515622001005 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 515622001006 GIY-YIG motif/motif A; other site 515622001007 putative active site [active] 515622001008 putative metal binding site [ion binding]; other site 515622001009 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 515622001010 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 515622001011 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 515622001012 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 515622001013 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 515622001014 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 515622001015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622001016 Coenzyme A binding pocket [chemical binding]; other site 515622001017 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 515622001018 Carboxylesterase family; Region: COesterase; pfam00135 515622001019 substrate binding pocket [chemical binding]; other site 515622001020 catalytic triad [active] 515622001021 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 515622001022 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 515622001023 substrate binding site [chemical binding]; other site 515622001024 active site 515622001025 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 515622001026 ligand binding site [chemical binding]; other site 515622001027 metal binding site [ion binding]; metal-binding site 515622001028 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 515622001029 substrate binding site [chemical binding]; other site 515622001030 active site 515622001031 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 515622001032 ligand binding site [chemical binding]; other site 515622001033 Cupin domain; Region: Cupin_2; pfam07883 515622001034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622001035 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622001036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622001037 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 515622001038 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 515622001039 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 515622001040 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622001041 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622001042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622001043 dimer interface [polypeptide binding]; other site 515622001044 conserved gate region; other site 515622001045 putative PBP binding loops; other site 515622001046 ABC-ATPase subunit interface; other site 515622001047 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622001048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622001049 dimer interface [polypeptide binding]; other site 515622001050 conserved gate region; other site 515622001051 ABC-ATPase subunit interface; other site 515622001052 NHL repeat; Region: NHL; pfam01436 515622001053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622001054 binding surface 515622001055 Tetratricopeptide repeat; Region: TPR_12; pfam13424 515622001056 TPR motif; other site 515622001057 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 515622001058 ABC-ATPase subunit interface; other site 515622001059 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622001060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622001061 dimer interface [polypeptide binding]; other site 515622001062 conserved gate region; other site 515622001063 putative PBP binding loops; other site 515622001064 ABC-ATPase subunit interface; other site 515622001065 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622001066 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 515622001067 active site 515622001068 catalytic triad [active] 515622001069 oxyanion hole [active] 515622001070 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 515622001071 active site 515622001072 catalytic site [active] 515622001073 substrate binding site [chemical binding]; other site 515622001074 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 515622001075 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 515622001076 homodimer interface [polypeptide binding]; other site 515622001077 substrate-cofactor binding pocket; other site 515622001078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622001079 catalytic residue [active] 515622001080 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 515622001081 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 515622001082 Beta-lactamase; Region: Beta-lactamase; pfam00144 515622001083 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 515622001084 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 515622001085 active site 515622001086 metal binding site [ion binding]; metal-binding site 515622001087 DNA binding site [nucleotide binding] 515622001088 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 515622001089 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 515622001090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622001091 Walker A/P-loop; other site 515622001092 ATP binding site [chemical binding]; other site 515622001093 Q-loop/lid; other site 515622001094 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 515622001095 ABC transporter signature motif; other site 515622001096 Walker B; other site 515622001097 D-loop; other site 515622001098 H-loop/switch region; other site 515622001099 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 515622001100 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622001101 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 515622001102 ApbE family; Region: ApbE; pfam02424 515622001103 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 515622001104 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 515622001105 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622001106 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622001107 metal binding site [ion binding]; metal-binding site 515622001108 active site 515622001109 I-site; other site 515622001110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515622001111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622001112 S-adenosylmethionine binding site [chemical binding]; other site 515622001113 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 515622001114 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 515622001115 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 515622001116 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 515622001117 Cl- selectivity filter; other site 515622001118 Cl- binding residues [ion binding]; other site 515622001119 pore gating glutamate residue; other site 515622001120 dimer interface [polypeptide binding]; other site 515622001121 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 515622001122 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 515622001123 putative ligand binding site [chemical binding]; other site 515622001124 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622001125 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 515622001126 TM-ABC transporter signature motif; other site 515622001127 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622001128 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 515622001129 TM-ABC transporter signature motif; other site 515622001130 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 515622001131 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 515622001132 Walker A/P-loop; other site 515622001133 ATP binding site [chemical binding]; other site 515622001134 Q-loop/lid; other site 515622001135 ABC transporter signature motif; other site 515622001136 Walker B; other site 515622001137 D-loop; other site 515622001138 H-loop/switch region; other site 515622001139 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 515622001140 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 515622001141 Walker A/P-loop; other site 515622001142 ATP binding site [chemical binding]; other site 515622001143 Q-loop/lid; other site 515622001144 ABC transporter signature motif; other site 515622001145 Walker B; other site 515622001146 D-loop; other site 515622001147 H-loop/switch region; other site 515622001148 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 515622001149 5'-3' exonuclease; Region: 53EXOc; smart00475 515622001150 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 515622001151 active site 515622001152 metal binding site 1 [ion binding]; metal-binding site 515622001153 putative 5' ssDNA interaction site; other site 515622001154 metal binding site 3; metal-binding site 515622001155 metal binding site 2 [ion binding]; metal-binding site 515622001156 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 515622001157 putative DNA binding site [nucleotide binding]; other site 515622001158 putative metal binding site [ion binding]; other site 515622001159 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 515622001160 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 515622001161 putative acyl-acceptor binding pocket; other site 515622001162 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622001163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001164 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 515622001165 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622001166 inhibitor-cofactor binding pocket; inhibition site 515622001167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622001168 catalytic residue [active] 515622001169 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 515622001170 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 515622001171 active site 515622001172 homodimer interface [polypeptide binding]; other site 515622001173 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 515622001174 Bacterial sugar transferase; Region: Bac_transf; pfam02397 515622001175 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 515622001176 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 515622001177 NAD(P) binding site [chemical binding]; other site 515622001178 homodimer interface [polypeptide binding]; other site 515622001179 substrate binding site [chemical binding]; other site 515622001180 active site 515622001181 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 515622001182 putative glycosyl transferase; Provisional; Region: PRK10307 515622001183 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 515622001184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622001185 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 515622001186 NAD(P) binding site [chemical binding]; other site 515622001187 active site 515622001188 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 515622001189 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 515622001190 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001191 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622001192 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 515622001193 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622001194 inhibitor-cofactor binding pocket; inhibition site 515622001195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622001196 catalytic residue [active] 515622001197 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 515622001198 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622001199 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622001200 active site 515622001201 Rubredoxin; Region: Rubredoxin; pfam00301 515622001202 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 515622001203 iron binding site [ion binding]; other site 515622001204 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622001205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001206 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 515622001207 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 515622001208 active site 515622001209 dimer interface [polypeptide binding]; other site 515622001210 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622001211 Ligand Binding Site [chemical binding]; other site 515622001212 Molecular Tunnel; other site 515622001213 WxcM-like, C-terminal; Region: FdtA; pfam05523 515622001214 Rubrerythrin [Energy production and conversion]; Region: COG1592 515622001215 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 515622001216 binuclear metal center [ion binding]; other site 515622001217 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 515622001218 iron binding site [ion binding]; other site 515622001219 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 515622001220 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 515622001221 Rubredoxin; Region: Rubredoxin; pfam00301 515622001222 iron binding site [ion binding]; other site 515622001223 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 515622001224 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001225 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622001226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622001228 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622001229 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 515622001230 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 515622001231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622001232 Coenzyme A binding pocket [chemical binding]; other site 515622001233 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 515622001234 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 515622001235 non-heme iron binding site [ion binding]; other site 515622001236 dimer interface [polypeptide binding]; other site 515622001237 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 515622001238 non-heme iron binding site [ion binding]; other site 515622001239 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 515622001240 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622001241 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622001242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622001243 Walker A/P-loop; other site 515622001244 ATP binding site [chemical binding]; other site 515622001245 Q-loop/lid; other site 515622001246 ABC transporter signature motif; other site 515622001247 Walker B; other site 515622001248 D-loop; other site 515622001249 H-loop/switch region; other site 515622001250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001251 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 515622001252 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 515622001253 GDP-Fucose binding site [chemical binding]; other site 515622001254 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 515622001255 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622001256 inhibitor-cofactor binding pocket; inhibition site 515622001257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622001258 catalytic residue [active] 515622001259 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622001260 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 515622001261 Ligand binding site; other site 515622001262 Putative Catalytic site; other site 515622001263 DXD motif; other site 515622001264 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 515622001265 putative trimer interface [polypeptide binding]; other site 515622001266 putative CoA binding site [chemical binding]; other site 515622001267 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 515622001268 putative trimer interface [polypeptide binding]; other site 515622001269 putative active site [active] 515622001270 putative substrate binding site [chemical binding]; other site 515622001271 putative CoA binding site [chemical binding]; other site 515622001272 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 515622001273 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 515622001274 Uncharacterized conserved protein [Function unknown]; Region: COG2006 515622001275 Domain of unknown function (DUF362); Region: DUF362; pfam04015 515622001276 Uncharacterized conserved protein [Function unknown]; Region: COG2006 515622001277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001278 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 515622001279 putative ADP-binding pocket [chemical binding]; other site 515622001280 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 515622001281 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 515622001282 Ligand binding site; other site 515622001283 Putative Catalytic site; other site 515622001284 DXD motif; other site 515622001285 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622001286 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001287 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622001288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622001289 active site 515622001290 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 515622001291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622001292 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 515622001293 NAD(P) binding site [chemical binding]; other site 515622001294 active site 515622001295 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 515622001296 trimer interface [polypeptide binding]; other site 515622001297 active site 515622001298 substrate binding site [chemical binding]; other site 515622001299 CoA binding site [chemical binding]; other site 515622001300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001301 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622001302 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 515622001303 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 515622001304 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 515622001305 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622001306 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622001307 active site 515622001308 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 515622001309 GDP-Fucose binding site [chemical binding]; other site 515622001310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001311 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622001312 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515622001313 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515622001314 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 515622001315 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 515622001316 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 515622001317 active site 515622001318 dimer interface [polypeptide binding]; other site 515622001319 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622001320 Ligand Binding Site [chemical binding]; other site 515622001321 Molecular Tunnel; other site 515622001322 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622001323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001324 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622001325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622001326 active site 515622001327 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622001328 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622001329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622001330 Walker A/P-loop; other site 515622001331 ATP binding site [chemical binding]; other site 515622001332 Q-loop/lid; other site 515622001333 ABC transporter signature motif; other site 515622001334 Walker B; other site 515622001335 D-loop; other site 515622001336 H-loop/switch region; other site 515622001337 Methyltransferase domain; Region: Methyltransf_22; pfam13383 515622001338 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 515622001339 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 515622001340 GDP-Fucose binding site [chemical binding]; other site 515622001341 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 515622001342 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 515622001343 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 515622001344 Substrate binding site; other site 515622001345 metal-binding site 515622001346 Methyltransferase domain; Region: Methyltransf_31; pfam13847 515622001347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622001348 S-adenosylmethionine binding site [chemical binding]; other site 515622001349 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 515622001350 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 515622001351 acyl-activating enzyme (AAE) consensus motif; other site 515622001352 AMP binding site [chemical binding]; other site 515622001353 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 515622001354 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u2_5s; cd10971 515622001355 putative active site [active] 515622001356 putative metal binding site [ion binding]; other site 515622001357 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515622001358 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515622001359 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515622001360 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 515622001361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622001362 FeS/SAM binding site; other site 515622001363 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 515622001364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622001365 NAD(P) binding site [chemical binding]; other site 515622001366 active site 515622001367 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 515622001368 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622001369 inhibitor-cofactor binding pocket; inhibition site 515622001370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622001371 catalytic residue [active] 515622001372 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 515622001373 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 515622001374 putative trimer interface [polypeptide binding]; other site 515622001375 putative CoA binding site [chemical binding]; other site 515622001376 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 515622001377 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 515622001378 putative trimer interface [polypeptide binding]; other site 515622001379 putative CoA binding site [chemical binding]; other site 515622001380 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 515622001381 NeuB family; Region: NeuB; pfam03102 515622001382 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 515622001383 NeuB binding interface [polypeptide binding]; other site 515622001384 putative substrate binding site [chemical binding]; other site 515622001385 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 515622001386 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 515622001387 active site 515622001388 homodimer interface [polypeptide binding]; other site 515622001389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515622001390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515622001391 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515622001392 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515622001393 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 515622001394 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 515622001395 ligand binding site; other site 515622001396 tetramer interface; other site 515622001397 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 515622001398 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 515622001399 active site 515622001400 dimer interface [polypeptide binding]; other site 515622001401 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622001402 Ligand Binding Site [chemical binding]; other site 515622001403 Molecular Tunnel; other site 515622001404 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 515622001405 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 515622001406 active site 515622001407 dimer interface [polypeptide binding]; other site 515622001408 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622001409 Ligand Binding Site [chemical binding]; other site 515622001410 Molecular Tunnel; other site 515622001411 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622001412 DHHW protein; Region: DHHW; pfam14286 515622001413 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 515622001414 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622001415 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622001416 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622001417 active site 515622001418 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 515622001419 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 515622001420 putative active site [active] 515622001421 putative metal binding site [ion binding]; other site 515622001422 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 515622001423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001424 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622001425 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622001426 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622001427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622001428 Walker A/P-loop; other site 515622001429 ATP binding site [chemical binding]; other site 515622001430 Q-loop/lid; other site 515622001431 ABC transporter signature motif; other site 515622001432 Walker B; other site 515622001433 D-loop; other site 515622001434 H-loop/switch region; other site 515622001435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622001436 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 515622001437 active site 515622001438 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 515622001439 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622001440 active site 515622001441 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 515622001442 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 515622001443 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 515622001444 putative metal binding residues [ion binding]; other site 515622001445 signature motif; other site 515622001446 dimer interface [polypeptide binding]; other site 515622001447 active site 515622001448 polyP binding site; other site 515622001449 substrate binding site [chemical binding]; other site 515622001450 acceptor-phosphate pocket; other site 515622001451 MgtC family; Region: MgtC; pfam02308 515622001452 Lamin Tail Domain; Region: LTD; pfam00932 515622001453 Fn3 associated; Region: Fn3_assoc; pfam13287 515622001454 CotH protein; Region: CotH; pfam08757 515622001455 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 515622001456 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622001457 active site 515622001458 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001459 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622001460 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622001461 active site 515622001462 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 515622001463 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622001464 active site 515622001465 nucleotide binding site [chemical binding]; other site 515622001466 HIGH motif; other site 515622001467 KMSKS motif; other site 515622001468 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 515622001469 Ligand binding site; other site 515622001470 Putative Catalytic site; other site 515622001471 DXD motif; other site 515622001472 Predicted membrane protein [Function unknown]; Region: COG2246 515622001473 GtrA-like protein; Region: GtrA; pfam04138 515622001474 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 515622001475 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 515622001476 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 515622001477 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 515622001478 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 515622001479 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 515622001480 putative dimer interface [polypeptide binding]; other site 515622001481 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 515622001482 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 515622001483 Mechanosensitive ion channel; Region: MS_channel; pfam00924 515622001484 thymidine kinase; Provisional; Region: PRK04296 515622001485 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 515622001486 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 515622001487 FlgN protein; Region: FlgN; pfam05130 515622001488 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 515622001489 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 515622001490 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 515622001491 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 515622001492 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 515622001493 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 515622001494 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 515622001495 FliW protein; Region: FliW; cl00740 515622001496 Global regulator protein family; Region: CsrA; cl00670 515622001497 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 515622001498 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 515622001499 FlaG protein; Region: FlaG; pfam03646 515622001500 flagellar capping protein; Validated; Region: fliD; PRK07737 515622001501 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 515622001502 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 515622001503 Flagellar protein FliS; Region: FliS; cl00654 515622001504 flagellin; Provisional; Region: PRK12804 515622001505 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 515622001506 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 515622001507 flagellin; Provisional; Region: PRK12804 515622001508 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 515622001509 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 515622001510 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 515622001511 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 515622001512 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 515622001513 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 515622001514 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 515622001515 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 515622001516 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 515622001517 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 515622001518 Probable Catalytic site; other site 515622001519 metal-binding site 515622001520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622001521 S-adenosylmethionine binding site [chemical binding]; other site 515622001522 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 515622001523 putative glycosyl transferase; Provisional; Region: PRK10073 515622001524 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622001525 active site 515622001526 Caenorhabditis protein of unknown function, DUF268; Region: DUF268; pfam03269 515622001527 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 515622001528 GDP-Fucose binding site [chemical binding]; other site 515622001529 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622001530 active site 515622001531 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622001532 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622001533 active site 515622001534 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622001535 active site 515622001536 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 515622001537 trimer interface [polypeptide binding]; other site 515622001538 active site 515622001539 CoA binding site [chemical binding]; other site 515622001540 Protein of unknown function (DUF616); Region: DUF616; pfam04765 515622001541 Methyltransferase domain; Region: Methyltransf_24; pfam13578 515622001542 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622001543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622001544 active site 515622001545 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 515622001546 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 515622001547 LicD family; Region: LicD; pfam04991 515622001548 LicD family; Region: LicD; pfam04991 515622001549 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 515622001550 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 515622001551 substrate binding site [chemical binding]; other site 515622001552 hexamer interface [polypeptide binding]; other site 515622001553 metal binding site [ion binding]; metal-binding site 515622001554 LicD family; Region: LicD; pfam04991 515622001555 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 515622001556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622001557 FeS/SAM binding site; other site 515622001558 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 515622001559 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 515622001560 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 515622001561 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 515622001562 Bacterial sugar transferase; Region: Bac_transf; pfam02397 515622001563 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 515622001564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622001565 NAD(P) binding site [chemical binding]; other site 515622001566 active site 515622001567 FAD dependent oxidoreductase; Region: DAO; pfam01266 515622001568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 515622001569 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 515622001570 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622001571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622001572 active site 515622001573 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 515622001574 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622001575 active site 515622001576 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 515622001577 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622001578 inhibitor-cofactor binding pocket; inhibition site 515622001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622001580 catalytic residue [active] 515622001581 conserved hypothetical integral membrane protein; Region: TIGR03766 515622001582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622001583 Radical SAM superfamily; Region: Radical_SAM; pfam04055 515622001584 FeS/SAM binding site; other site 515622001585 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 515622001586 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 515622001587 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 515622001588 Ligand binding site; other site 515622001589 Putative Catalytic site; other site 515622001590 DXD motif; other site 515622001591 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 515622001592 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 515622001593 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 515622001594 active site 515622001595 catalytic triad [active] 515622001596 oxyanion hole [active] 515622001597 hypothetical protein; Provisional; Region: PRK07208 515622001598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 515622001599 hydroxyglutarate oxidase; Provisional; Region: PRK11728 515622001600 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 515622001601 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 515622001602 Ligand binding site; other site 515622001603 Putative Catalytic site; other site 515622001604 DXD motif; other site 515622001605 NnrS protein; Region: NnrS; cl01258 515622001606 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 515622001607 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 515622001608 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 515622001609 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 515622001610 ATP-binding site [chemical binding]; other site 515622001611 Sugar specificity; other site 515622001612 Pyrimidine base specificity; other site 515622001613 LicD family; Region: LicD; cl01378 515622001614 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 515622001615 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 515622001616 active site 515622001617 metal-binding site 515622001618 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 515622001619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 515622001620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622001621 homodimer interface [polypeptide binding]; other site 515622001622 catalytic residue [active] 515622001623 ornithine cyclodeaminase; Validated; Region: PRK08618 515622001624 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 515622001625 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 515622001626 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 515622001627 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622001628 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 515622001629 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 515622001630 active site 515622001631 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 515622001632 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 515622001633 NAD binding site [chemical binding]; other site 515622001634 substrate binding site [chemical binding]; other site 515622001635 homodimer interface [polypeptide binding]; other site 515622001636 active site 515622001637 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 515622001638 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 515622001639 substrate binding site; other site 515622001640 tetramer interface; other site 515622001641 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 515622001642 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 515622001643 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 515622001644 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 515622001645 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 515622001646 Walker A/P-loop; other site 515622001647 ATP binding site [chemical binding]; other site 515622001648 Q-loop/lid; other site 515622001649 ABC transporter signature motif; other site 515622001650 Walker B; other site 515622001651 D-loop; other site 515622001652 H-loop/switch region; other site 515622001653 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 515622001654 putative carbohydrate binding site [chemical binding]; other site 515622001655 Methyltransferase domain; Region: Methyltransf_23; pfam13489 515622001656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622001657 S-adenosylmethionine binding site [chemical binding]; other site 515622001658 Defects in morphology protein 1, mitochondrial precursor; Region: Morph_protein1; pfam09810 515622001659 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622001660 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 515622001661 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 515622001662 Probable Catalytic site; other site 515622001663 metal-binding site 515622001664 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622001665 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 515622001666 Probable Catalytic site; other site 515622001667 metal-binding site 515622001668 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 515622001669 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 515622001670 Probable Catalytic site; other site 515622001671 metal-binding site 515622001672 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 515622001673 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 515622001674 active site 515622001675 substrate binding site [chemical binding]; other site 515622001676 metal binding site [ion binding]; metal-binding site 515622001677 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 515622001678 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622001679 Probable Catalytic site; other site 515622001680 metal-binding site 515622001681 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 515622001682 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 515622001683 Probable Catalytic site; other site 515622001684 metal-binding site 515622001685 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 515622001686 Bacterial sugar transferase; Region: Bac_transf; pfam02397 515622001687 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 515622001688 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 515622001689 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 515622001690 active site 515622001691 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 515622001692 synthetase active site [active] 515622001693 NTP binding site [chemical binding]; other site 515622001694 metal binding site [ion binding]; metal-binding site 515622001695 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 515622001696 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 515622001697 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 515622001698 G5 domain; Region: G5; pfam07501 515622001699 Peptidase family M23; Region: Peptidase_M23; pfam01551 515622001700 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 515622001701 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 515622001702 hinge; other site 515622001703 active site 515622001704 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515622001705 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622001706 Zn2+ binding site [ion binding]; other site 515622001707 Mg2+ binding site [ion binding]; other site 515622001708 Predicted membrane protein [Function unknown]; Region: COG3601 515622001709 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 515622001710 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 515622001711 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 515622001712 Glycoprotease family; Region: Peptidase_M22; pfam00814 515622001713 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 515622001714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622001715 Coenzyme A binding pocket [chemical binding]; other site 515622001716 ribonuclease Z; Reviewed; Region: PRK00055 515622001717 UGMP family protein; Validated; Region: PRK09604 515622001718 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 515622001719 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 515622001720 substrate binding site; other site 515622001721 dimer interface; other site 515622001722 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622001723 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622001724 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 515622001725 trimer interface [polypeptide binding]; other site 515622001726 active site 515622001727 substrate binding site [chemical binding]; other site 515622001728 CoA binding site [chemical binding]; other site 515622001729 Isochorismatase family; Region: Isochorismatase; pfam00857 515622001730 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 515622001731 catalytic triad [active] 515622001732 conserved cis-peptide bond; other site 515622001733 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 515622001734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622001735 motif II; other site 515622001736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622001737 S-adenosylmethionine binding site [chemical binding]; other site 515622001738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622001739 Coenzyme A binding pocket [chemical binding]; other site 515622001740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622001741 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 515622001742 NAD(P) binding site [chemical binding]; other site 515622001743 active site 515622001744 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622001745 Zn2+ binding site [ion binding]; other site 515622001746 Mg2+ binding site [ion binding]; other site 515622001747 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 515622001748 putative NADH binding site [chemical binding]; other site 515622001749 putative active site [active] 515622001750 nudix motif; other site 515622001751 putative metal binding site [ion binding]; other site 515622001752 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 515622001753 putative active site [active] 515622001754 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 515622001755 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 515622001756 DNA binding residues [nucleotide binding] 515622001757 dimer interface [polypeptide binding]; other site 515622001758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 515622001759 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 515622001760 ADP-ribose binding site [chemical binding]; other site 515622001761 active site 515622001762 nudix motif; other site 515622001763 metal binding site [ion binding]; metal-binding site 515622001764 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 515622001765 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 515622001766 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 515622001767 active site 515622001768 dimer interface [polypeptide binding]; other site 515622001769 motif 1; other site 515622001770 motif 2; other site 515622001771 motif 3; other site 515622001772 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 515622001773 anticodon binding site; other site 515622001774 Protein of unknown function (DUF402); Region: DUF402; cl00979 515622001775 Pilot protein MxiM; Region: MxiM; pfam11441 515622001776 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622001777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622001778 metal binding site [ion binding]; metal-binding site 515622001779 active site 515622001780 I-site; other site 515622001781 Bacterial transcriptional activator domain; Region: BTAD; smart01043 515622001782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 515622001783 binding surface 515622001784 TPR motif; other site 515622001785 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 515622001786 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 515622001787 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 515622001788 synthetase active site [active] 515622001789 NTP binding site [chemical binding]; other site 515622001790 metal binding site [ion binding]; metal-binding site 515622001791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622001792 S-adenosylmethionine binding site [chemical binding]; other site 515622001793 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 515622001794 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 515622001795 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 515622001796 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 515622001797 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 515622001798 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 515622001799 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 515622001800 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 515622001801 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 515622001802 putative translocon binding site; other site 515622001803 protein-rRNA interface [nucleotide binding]; other site 515622001804 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 515622001805 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 515622001806 G-X-X-G motif; other site 515622001807 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 515622001808 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 515622001809 23S rRNA interface [nucleotide binding]; other site 515622001810 5S rRNA interface [nucleotide binding]; other site 515622001811 putative antibiotic binding site [chemical binding]; other site 515622001812 L25 interface [polypeptide binding]; other site 515622001813 L27 interface [polypeptide binding]; other site 515622001814 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 515622001815 putative translocon interaction site; other site 515622001816 23S rRNA interface [nucleotide binding]; other site 515622001817 signal recognition particle (SRP54) interaction site; other site 515622001818 L23 interface [polypeptide binding]; other site 515622001819 trigger factor interaction site; other site 515622001820 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 515622001821 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 515622001822 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 515622001823 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 515622001824 RNA binding site [nucleotide binding]; other site 515622001825 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 515622001826 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 515622001827 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 515622001828 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 515622001829 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 515622001830 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 515622001831 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 515622001832 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 515622001833 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 515622001834 23S rRNA interface [nucleotide binding]; other site 515622001835 L21e interface [polypeptide binding]; other site 515622001836 5S rRNA interface [nucleotide binding]; other site 515622001837 L27 interface [polypeptide binding]; other site 515622001838 L5 interface [polypeptide binding]; other site 515622001839 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 515622001840 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 515622001841 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 515622001842 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 515622001843 23S rRNA binding site [nucleotide binding]; other site 515622001844 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 515622001845 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 515622001846 SecY translocase; Region: SecY; pfam00344 515622001847 adenylate kinase; Reviewed; Region: adk; PRK00279 515622001848 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 515622001849 AMP-binding site [chemical binding]; other site 515622001850 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 515622001851 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 515622001852 active site 515622001853 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 515622001854 rRNA binding site [nucleotide binding]; other site 515622001855 predicted 30S ribosome binding site; other site 515622001856 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 515622001857 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 515622001858 active site 515622001859 catalytic tetrad [active] 515622001860 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 515622001861 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 515622001862 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 515622001863 30S ribosomal protein S13; Region: bact_S13; TIGR03631 515622001864 30S ribosomal protein S11; Validated; Region: PRK05309 515622001865 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 515622001866 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 515622001867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515622001868 RNA binding surface [nucleotide binding]; other site 515622001869 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 515622001870 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 515622001871 alphaNTD homodimer interface [polypeptide binding]; other site 515622001872 alphaNTD - beta interaction site [polypeptide binding]; other site 515622001873 alphaNTD - beta' interaction site [polypeptide binding]; other site 515622001874 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 515622001875 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 515622001876 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 515622001877 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 515622001878 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 515622001879 Walker A/P-loop; other site 515622001880 ATP binding site [chemical binding]; other site 515622001881 Q-loop/lid; other site 515622001882 ABC transporter signature motif; other site 515622001883 Walker B; other site 515622001884 D-loop; other site 515622001885 H-loop/switch region; other site 515622001886 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 515622001887 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 515622001888 Walker A/P-loop; other site 515622001889 ATP binding site [chemical binding]; other site 515622001890 Q-loop/lid; other site 515622001891 ABC transporter signature motif; other site 515622001892 Walker B; other site 515622001893 D-loop; other site 515622001894 H-loop/switch region; other site 515622001895 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 515622001896 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 515622001897 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 515622001898 dimerization interface 3.5A [polypeptide binding]; other site 515622001899 active site 515622001900 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 515622001901 23S rRNA interface [nucleotide binding]; other site 515622001902 L3 interface [polypeptide binding]; other site 515622001903 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 515622001904 potential frameshift: common BLAST hit: gi|269120003|ref|YP_003308180.1| integrase 515622001905 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 515622001906 active site 515622001907 catalytic residues [active] 515622001908 DNA binding site [nucleotide binding] 515622001909 Int/Topo IB signature motif; other site 515622001910 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622001911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622001912 non-specific DNA binding site [nucleotide binding]; other site 515622001913 salt bridge; other site 515622001914 sequence-specific DNA binding site [nucleotide binding]; other site 515622001915 AAA domain; Region: AAA_25; pfam13481 515622001916 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622001917 Walker A motif; other site 515622001918 ATP binding site [chemical binding]; other site 515622001919 Walker B motif; other site 515622001920 Transposase; Region: DEDD_Tnp_IS110; pfam01548 515622001921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 515622001922 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 515622001923 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 515622001924 Predicted transcriptional regulators [Transcription]; Region: COG1733 515622001925 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 515622001926 ACGX-repeat peptide; Region: target_ACGX; TIGR04341 515622001927 radical SAM/SPASM domain protein, ACGX system; Region: rSAM_ACGX; TIGR04340 515622001928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622001929 FeS/SAM binding site; other site 515622001930 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 515622001931 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 515622001932 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 515622001933 NAD(P) binding site [chemical binding]; other site 515622001934 Transposase IS200 like; Region: Y1_Tnp; pfam01797 515622001935 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 515622001936 Divergent AAA domain; Region: AAA_4; pfam04326 515622001937 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 515622001938 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 515622001939 non-specific DNA interactions [nucleotide binding]; other site 515622001940 DNA binding site [nucleotide binding] 515622001941 sequence specific DNA binding site [nucleotide binding]; other site 515622001942 putative cAMP binding site [chemical binding]; other site 515622001943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 515622001944 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 515622001945 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622001946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622001947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622001948 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622001949 metal binding site [ion binding]; metal-binding site 515622001950 active site 515622001951 I-site; other site 515622001952 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622001953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622001954 non-specific DNA binding site [nucleotide binding]; other site 515622001955 salt bridge; other site 515622001956 sequence-specific DNA binding site [nucleotide binding]; other site 515622001957 Tetratricopeptide repeat; Region: TPR_16; pfam13432 515622001958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622001959 binding surface 515622001960 TPR motif; other site 515622001961 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 515622001962 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622001963 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622001964 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 515622001965 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622001966 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 515622001967 putative acetyltransferase YhhY; Provisional; Region: PRK10140 515622001968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622001969 Coenzyme A binding pocket [chemical binding]; other site 515622001970 Transcriptional regulators [Transcription]; Region: MarR; COG1846 515622001971 MarR family; Region: MarR_2; pfam12802 515622001972 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 515622001973 FMN-binding domain; Region: FMN_bind; cl01081 515622001974 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 515622001975 nudix motif; other site 515622001976 Protein of unknown function (DUF419); Region: DUF419; pfam04237 515622001977 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 515622001978 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 515622001979 active site 515622001980 DNA binding site [nucleotide binding] 515622001981 Methyltransferase domain; Region: Methyltransf_31; pfam13847 515622001982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622001983 S-adenosylmethionine binding site [chemical binding]; other site 515622001984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622001985 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 515622001986 Walker A/P-loop; other site 515622001987 ATP binding site [chemical binding]; other site 515622001988 Q-loop/lid; other site 515622001989 ABC transporter signature motif; other site 515622001990 Walker B; other site 515622001991 D-loop; other site 515622001992 H-loop/switch region; other site 515622001993 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 515622001994 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 515622001995 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 515622001996 Uncharacterized conserved protein [Function unknown]; Region: COG1284 515622001997 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 515622001998 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 515622001999 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 515622002000 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 515622002001 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 515622002002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622002003 motif II; other site 515622002004 LytTr DNA-binding domain; Region: LytTR; pfam04397 515622002005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 515622002006 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 515622002007 Walker A/P-loop; other site 515622002008 ATP binding site [chemical binding]; other site 515622002009 Q-loop/lid; other site 515622002010 ABC transporter signature motif; other site 515622002011 Walker B; other site 515622002012 D-loop; other site 515622002013 H-loop/switch region; other site 515622002014 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 515622002015 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 515622002016 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 515622002017 active site 515622002018 Predicted transcriptional regulator [Transcription]; Region: COG4189 515622002019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515622002020 putative DNA binding site [nucleotide binding]; other site 515622002021 dimerization interface [polypeptide binding]; other site 515622002022 putative Zn2+ binding site [ion binding]; other site 515622002023 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622002024 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622002025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622002026 dimer interface [polypeptide binding]; other site 515622002027 conserved gate region; other site 515622002028 putative PBP binding loops; other site 515622002029 ABC-ATPase subunit interface; other site 515622002030 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622002031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622002032 dimer interface [polypeptide binding]; other site 515622002033 conserved gate region; other site 515622002034 putative PBP binding loops; other site 515622002035 ABC-ATPase subunit interface; other site 515622002036 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515622002037 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515622002038 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515622002039 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 515622002040 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 515622002041 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 515622002042 mannonate dehydratase; Provisional; Region: PRK03906 515622002043 mannonate dehydratase; Region: uxuA; TIGR00695 515622002044 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 515622002045 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 515622002046 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 515622002047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 515622002048 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 515622002049 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 515622002050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622002051 active site 515622002052 phosphorylation site [posttranslational modification] 515622002053 intermolecular recognition site; other site 515622002054 dimerization interface [polypeptide binding]; other site 515622002055 LytTr DNA-binding domain; Region: LytTR; smart00850 515622002056 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 515622002057 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515622002058 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515622002059 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515622002060 MFS/sugar transport protein; Region: MFS_2; pfam13347 515622002061 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 515622002062 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515622002063 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515622002064 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 515622002065 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515622002066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622002067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622002068 DNA binding site [nucleotide binding] 515622002069 domain linker motif; other site 515622002070 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622002071 dimerization interface [polypeptide binding]; other site 515622002072 ligand binding site [chemical binding]; other site 515622002073 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622002074 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622002075 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622002076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622002077 dimer interface [polypeptide binding]; other site 515622002078 conserved gate region; other site 515622002079 putative PBP binding loops; other site 515622002080 ABC-ATPase subunit interface; other site 515622002081 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622002082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622002083 dimer interface [polypeptide binding]; other site 515622002084 conserved gate region; other site 515622002085 putative PBP binding loops; other site 515622002086 ABC-ATPase subunit interface; other site 515622002087 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 515622002088 homodimer interface [polypeptide binding]; other site 515622002089 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 515622002090 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 515622002091 active site 515622002092 homodimer interface [polypeptide binding]; other site 515622002093 catalytic site [active] 515622002094 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 515622002095 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 515622002096 putative active site [active] 515622002097 putative catalytic site [active] 515622002098 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 515622002099 Methyltransferase domain; Region: Methyltransf_31; pfam13847 515622002100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622002101 S-adenosylmethionine binding site [chemical binding]; other site 515622002102 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 515622002103 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 515622002104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 515622002105 active site 515622002106 catalytic tetrad [active] 515622002107 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 515622002108 Cupin domain; Region: Cupin_2; pfam07883 515622002109 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622002110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622002111 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 515622002112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622002113 non-specific DNA binding site [nucleotide binding]; other site 515622002114 salt bridge; other site 515622002115 sequence-specific DNA binding site [nucleotide binding]; other site 515622002116 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 515622002117 Bacterial sugar transferase; Region: Bac_transf; pfam02397 515622002118 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 515622002119 putative ADP-binding pocket [chemical binding]; other site 515622002120 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622002121 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 515622002122 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 515622002123 active site 515622002124 dimer interface [polypeptide binding]; other site 515622002125 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622002126 Ligand Binding Site [chemical binding]; other site 515622002127 Molecular Tunnel; other site 515622002128 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622002129 active site 515622002130 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 515622002131 Protein of unknown function (DUF616); Region: DUF616; pfam04765 515622002132 colanic acid exporter; Provisional; Region: PRK10459 515622002133 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 515622002134 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622002135 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622002136 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 515622002137 potential frameshift: common BLAST hit: gi|195953980|ref|YP_002122270.1| NAD-dependent epimerase/dehydratase 515622002138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622002139 NAD(P) binding site [chemical binding]; other site 515622002140 active site 515622002141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622002142 EamA-like transporter family; Region: EamA; pfam00892 515622002143 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 515622002144 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 515622002145 active site 515622002146 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 515622002147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622002148 FeS/SAM binding site; other site 515622002149 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 515622002150 active site 515622002151 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 515622002152 TspO/MBR family; Region: TspO_MBR; cl01379 515622002153 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622002154 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622002155 dimer interface [polypeptide binding]; other site 515622002156 putative CheW interface [polypeptide binding]; other site 515622002157 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 515622002158 putative active site [active] 515622002159 nucleotide binding site [chemical binding]; other site 515622002160 nudix motif; other site 515622002161 putative metal binding site [ion binding]; other site 515622002162 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 515622002163 trehalose synthase; Region: treS_nterm; TIGR02456 515622002164 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 515622002165 active site 515622002166 catalytic site [active] 515622002167 hypothetical protein; Provisional; Region: PRK13690 515622002168 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 515622002169 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 515622002170 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622002171 metal binding site [ion binding]; metal-binding site 515622002172 active site 515622002173 I-site; other site 515622002174 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622002175 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 515622002176 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 515622002177 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 515622002178 Part of AAA domain; Region: AAA_19; pfam13245 515622002179 Family description; Region: UvrD_C_2; pfam13538 515622002180 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 515622002181 CBD_II domain; Region: CBD_II; smart00637 515622002182 Cellulose binding domain; Region: CBM_2; pfam00553 515622002183 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 515622002184 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 515622002185 substrate binding site [chemical binding]; other site 515622002186 active site 515622002187 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 515622002188 metal binding site [ion binding]; metal-binding site 515622002189 ligand binding site [chemical binding]; other site 515622002190 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 515622002191 metal binding site [ion binding]; metal-binding site 515622002192 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 515622002193 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 515622002194 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 515622002195 putative sugar binding sites [chemical binding]; other site 515622002196 Q-X-W motif; other site 515622002197 Cellulose binding domain; Region: CBM_2; pfam00553 515622002198 CAAX protease self-immunity; Region: Abi; pfam02517 515622002199 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 515622002200 active site 515622002201 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 515622002202 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 515622002203 active site 515622002204 FMN binding site [chemical binding]; other site 515622002205 substrate binding site [chemical binding]; other site 515622002206 putative catalytic residue [active] 515622002207 Acylphosphatase; Region: Acylphosphatase; pfam00708 515622002208 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 515622002209 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 515622002210 Walker A/P-loop; other site 515622002211 ATP binding site [chemical binding]; other site 515622002212 Q-loop/lid; other site 515622002213 ABC transporter signature motif; other site 515622002214 Walker B; other site 515622002215 D-loop; other site 515622002216 H-loop/switch region; other site 515622002217 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 515622002218 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 515622002219 ABC-ATPase subunit interface; other site 515622002220 dimer interface [polypeptide binding]; other site 515622002221 putative PBP binding regions; other site 515622002222 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 515622002223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 515622002224 ABC-ATPase subunit interface; other site 515622002225 dimer interface [polypeptide binding]; other site 515622002226 putative PBP binding regions; other site 515622002227 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 515622002228 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 515622002229 intersubunit interface [polypeptide binding]; other site 515622002230 FtsX-like permease family; Region: FtsX; pfam02687 515622002231 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 515622002232 FtsX-like permease family; Region: FtsX; pfam02687 515622002233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 515622002234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 515622002235 Walker A/P-loop; other site 515622002236 ATP binding site [chemical binding]; other site 515622002237 Q-loop/lid; other site 515622002238 ABC transporter signature motif; other site 515622002239 Walker B; other site 515622002240 D-loop; other site 515622002241 H-loop/switch region; other site 515622002242 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622002243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622002244 active site 515622002245 phosphorylation site [posttranslational modification] 515622002246 intermolecular recognition site; other site 515622002247 dimerization interface [polypeptide binding]; other site 515622002248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622002249 DNA binding site [nucleotide binding] 515622002250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622002251 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622002252 dimer interface [polypeptide binding]; other site 515622002253 phosphorylation site [posttranslational modification] 515622002254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622002255 ATP binding site [chemical binding]; other site 515622002256 Mg2+ binding site [ion binding]; other site 515622002257 G-X-G motif; other site 515622002258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 515622002259 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 515622002260 Probable transposase; Region: OrfB_IS605; pfam01385 515622002261 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 515622002262 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 515622002263 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 515622002264 domain interaction interfaces [polypeptide binding]; other site 515622002265 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 515622002266 domain interaction interfaces [polypeptide binding]; other site 515622002267 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 515622002268 domain interaction interfaces [polypeptide binding]; other site 515622002269 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 515622002270 domain interaction interfaces [polypeptide binding]; other site 515622002271 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 515622002272 active site 515622002273 catalytic site [active] 515622002274 Cache domain; Region: Cache_1; pfam02743 515622002275 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515622002276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622002277 Zn2+ binding site [ion binding]; other site 515622002278 Mg2+ binding site [ion binding]; other site 515622002279 Bacterial SH3 domain; Region: SH3_3; cl17532 515622002280 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 515622002281 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 515622002282 Ligand binding site; other site 515622002283 Putative Catalytic site; other site 515622002284 DXD motif; other site 515622002285 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622002286 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622002287 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622002288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622002289 active site 515622002290 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 515622002291 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622002292 active site 515622002293 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 515622002294 Part of AAA domain; Region: AAA_19; pfam13245 515622002295 Family description; Region: UvrD_C_2; pfam13538 515622002296 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 515622002297 active site 515622002298 NTP binding site [chemical binding]; other site 515622002299 metal binding triad [ion binding]; metal-binding site 515622002300 antibiotic binding site [chemical binding]; other site 515622002301 HEPN domain; Region: HEPN; cl00824 515622002302 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622002303 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622002304 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622002305 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622002306 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622002307 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622002308 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 515622002309 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 515622002310 catalytic residues [active] 515622002311 catalytic nucleophile [active] 515622002312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622002313 non-specific DNA binding site [nucleotide binding]; other site 515622002314 salt bridge; other site 515622002315 sequence-specific DNA binding site [nucleotide binding]; other site 515622002316 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622002317 active site 515622002318 DNA binding site [nucleotide binding] 515622002319 Int/Topo IB signature motif; other site 515622002320 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 515622002321 GAF domain; Region: GAF_3; pfam13492 515622002322 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 515622002323 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 515622002324 Walker A/P-loop; other site 515622002325 ATP binding site [chemical binding]; other site 515622002326 Q-loop/lid; other site 515622002327 ABC transporter signature motif; other site 515622002328 Walker B; other site 515622002329 D-loop; other site 515622002330 H-loop/switch region; other site 515622002331 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 515622002332 Remorin, C-terminal region; Region: Remorin_C; pfam03763 515622002333 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 515622002334 FtsX-like permease family; Region: FtsX; pfam02687 515622002335 FtsX-like permease family; Region: FtsX; pfam02687 515622002336 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 515622002337 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 515622002338 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 515622002339 Ca binding site [ion binding]; other site 515622002340 active site 515622002341 catalytic site [active] 515622002342 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 515622002343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622002344 motif II; other site 515622002345 oligoendopeptidase F; Region: pepF; TIGR00181 515622002346 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 515622002347 active site 515622002348 Zn binding site [ion binding]; other site 515622002349 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 515622002350 Predicted integral membrane protein [Function unknown]; Region: COG5652 515622002351 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622002352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622002353 metal binding site [ion binding]; metal-binding site 515622002354 active site 515622002355 I-site; other site 515622002356 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 515622002357 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 515622002358 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 515622002359 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 515622002360 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 515622002361 23S rRNA binding site [nucleotide binding]; other site 515622002362 L21 binding site [polypeptide binding]; other site 515622002363 L13 binding site [polypeptide binding]; other site 515622002364 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 515622002365 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 515622002366 metal binding site [ion binding]; metal-binding site 515622002367 dimer interface [polypeptide binding]; other site 515622002368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622002369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622002370 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 515622002371 Melibiase; Region: Melibiase; pfam02065 515622002372 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 515622002373 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 515622002374 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 515622002375 G1 box; other site 515622002376 putative GEF interaction site [polypeptide binding]; other site 515622002377 GTP/Mg2+ binding site [chemical binding]; other site 515622002378 Switch I region; other site 515622002379 G2 box; other site 515622002380 G3 box; other site 515622002381 Switch II region; other site 515622002382 G4 box; other site 515622002383 G5 box; other site 515622002384 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 515622002385 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 515622002386 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 515622002387 YacP-like NYN domain; Region: NYN_YacP; pfam05991 515622002388 Predicted transcriptional regulator [Transcription]; Region: COG4189 515622002389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515622002390 dimerization interface [polypeptide binding]; other site 515622002391 putative DNA binding site [nucleotide binding]; other site 515622002392 putative Zn2+ binding site [ion binding]; other site 515622002393 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 515622002394 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 515622002395 GDP-binding site [chemical binding]; other site 515622002396 ACT binding site; other site 515622002397 IMP binding site; other site 515622002398 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622002399 dimerization interface [polypeptide binding]; other site 515622002400 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622002401 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622002402 dimer interface [polypeptide binding]; other site 515622002403 putative CheW interface [polypeptide binding]; other site 515622002404 HAMP domain; Region: HAMP; pfam00672 515622002405 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 515622002406 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 515622002407 trehalose repressor; Provisional; Region: treR; PRK09492 515622002408 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 515622002409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 515622002410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 515622002411 active site 515622002412 motif I; other site 515622002413 motif II; other site 515622002414 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 515622002415 anti sigma factor interaction site; other site 515622002416 regulatory phosphorylation site [posttranslational modification]; other site 515622002417 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 515622002418 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 515622002419 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 515622002420 putative active site [active] 515622002421 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622002422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622002423 Walker A/P-loop; other site 515622002424 ATP binding site [chemical binding]; other site 515622002425 Q-loop/lid; other site 515622002426 ABC transporter signature motif; other site 515622002427 Walker B; other site 515622002428 D-loop; other site 515622002429 H-loop/switch region; other site 515622002430 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 515622002431 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622002432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622002433 Walker A/P-loop; other site 515622002434 ATP binding site [chemical binding]; other site 515622002435 Q-loop/lid; other site 515622002436 ABC transporter signature motif; other site 515622002437 Walker B; other site 515622002438 D-loop; other site 515622002439 H-loop/switch region; other site 515622002440 Chain length determinant protein; Region: Wzz; cl15801 515622002441 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 515622002442 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 515622002443 active site 515622002444 catalytic site [active] 515622002445 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 515622002446 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 515622002447 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 515622002448 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515622002449 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 515622002450 putative glycosyl transferase; Provisional; Region: PRK10307 515622002451 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 515622002452 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 515622002453 trimer interface [polypeptide binding]; other site 515622002454 active site 515622002455 substrate binding site [chemical binding]; other site 515622002456 CoA binding site [chemical binding]; other site 515622002457 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622002458 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 515622002459 putative metal binding site; other site 515622002460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622002461 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 515622002462 putative ADP-binding pocket [chemical binding]; other site 515622002463 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 515622002464 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 515622002465 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 515622002466 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 515622002467 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 515622002468 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 515622002469 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 515622002470 trimer interface [polypeptide binding]; other site 515622002471 active site 515622002472 substrate binding site [chemical binding]; other site 515622002473 CoA binding site [chemical binding]; other site 515622002474 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622002475 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622002476 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 515622002477 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 515622002478 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 515622002479 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 515622002480 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 515622002481 active site 515622002482 oxyanion hole [active] 515622002483 catalytic triad [active] 515622002484 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 515622002485 bZIP transcription factor; Region: bZIP_1; pfam00170 515622002486 DNA binding site [nucleotide binding] 515622002487 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 515622002488 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 515622002489 glutaminase active site [active] 515622002490 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 515622002491 dimer interface [polypeptide binding]; other site 515622002492 active site 515622002493 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 515622002494 dimer interface [polypeptide binding]; other site 515622002495 active site 515622002496 Predicted integral membrane protein [Function unknown]; Region: COG5652 515622002497 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 515622002498 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 515622002499 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 515622002500 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 515622002501 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 515622002502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622002503 motif II; other site 515622002504 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 515622002505 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515622002506 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515622002507 DNA binding residues [nucleotide binding] 515622002508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 515622002509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 515622002510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 515622002511 dimerization interface [polypeptide binding]; other site 515622002512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622002513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622002514 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 515622002515 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 515622002516 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 515622002517 dimerization interface [polypeptide binding]; other site 515622002518 ATP binding site [chemical binding]; other site 515622002519 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 515622002520 dimerization interface [polypeptide binding]; other site 515622002521 ATP binding site [chemical binding]; other site 515622002522 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 515622002523 putative active site [active] 515622002524 catalytic triad [active] 515622002525 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 515622002526 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 515622002527 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 515622002528 catalytic site [active] 515622002529 subunit interface [polypeptide binding]; other site 515622002530 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 515622002531 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515622002532 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 515622002533 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 515622002534 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515622002535 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515622002536 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 515622002537 IMP binding site; other site 515622002538 dimer interface [polypeptide binding]; other site 515622002539 interdomain contacts; other site 515622002540 partial ornithine binding site; other site 515622002541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622002542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622002543 dimer interface [polypeptide binding]; other site 515622002544 phosphorylation site [posttranslational modification] 515622002545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622002546 ATP binding site [chemical binding]; other site 515622002547 Mg2+ binding site [ion binding]; other site 515622002548 G-X-G motif; other site 515622002549 Response regulator receiver domain; Region: Response_reg; pfam00072 515622002550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622002551 active site 515622002552 phosphorylation site [posttranslational modification] 515622002553 intermolecular recognition site; other site 515622002554 dimerization interface [polypeptide binding]; other site 515622002555 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 515622002556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 515622002557 Response regulator receiver domain; Region: Response_reg; pfam00072 515622002558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622002559 active site 515622002560 phosphorylation site [posttranslational modification] 515622002561 intermolecular recognition site; other site 515622002562 dimerization interface [polypeptide binding]; other site 515622002563 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 515622002564 Dehydroquinase class II; Region: DHquinase_II; pfam01220 515622002565 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 515622002566 trimer interface [polypeptide binding]; other site 515622002567 active site 515622002568 dimer interface [polypeptide binding]; other site 515622002569 CHASE domain; Region: CHASE; cl01369 515622002570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622002571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622002572 metal binding site [ion binding]; metal-binding site 515622002573 active site 515622002574 I-site; other site 515622002575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 515622002576 PAS fold; Region: PAS_3; pfam08447 515622002577 putative active site [active] 515622002578 heme pocket [chemical binding]; other site 515622002579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622002580 metal binding site [ion binding]; metal-binding site 515622002581 active site 515622002582 I-site; other site 515622002583 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622002584 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 515622002585 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 515622002586 substrate binding pocket [chemical binding]; other site 515622002587 catalytic triad [active] 515622002588 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515622002589 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515622002590 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 515622002591 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515622002592 Predicted membrane protein [Function unknown]; Region: COG2364 515622002593 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 515622002594 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 515622002595 AIR carboxylase; Region: AIRC; smart01001 515622002596 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 515622002597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622002598 Walker A/P-loop; other site 515622002599 ATP binding site [chemical binding]; other site 515622002600 Q-loop/lid; other site 515622002601 ABC transporter signature motif; other site 515622002602 Walker B; other site 515622002603 D-loop; other site 515622002604 H-loop/switch region; other site 515622002605 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 515622002606 4Fe-4S binding domain; Region: Fer4_6; pfam12837 515622002607 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 515622002608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622002609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622002610 dimer interface [polypeptide binding]; other site 515622002611 phosphorylation site [posttranslational modification] 515622002612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622002613 ATP binding site [chemical binding]; other site 515622002614 Mg2+ binding site [ion binding]; other site 515622002615 G-X-G motif; other site 515622002616 Response regulator receiver domain; Region: Response_reg; pfam00072 515622002617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622002618 active site 515622002619 phosphorylation site [posttranslational modification] 515622002620 intermolecular recognition site; other site 515622002621 dimerization interface [polypeptide binding]; other site 515622002622 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 515622002623 Response regulator receiver domain; Region: Response_reg; pfam00072 515622002624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622002625 active site 515622002626 phosphorylation site [posttranslational modification] 515622002627 intermolecular recognition site; other site 515622002628 dimerization interface [polypeptide binding]; other site 515622002629 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 515622002630 active site 515622002631 dimer interface [polypeptide binding]; other site 515622002632 TraX protein; Region: TraX; pfam05857 515622002633 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622002634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622002635 Coenzyme A binding pocket [chemical binding]; other site 515622002636 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 515622002637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622002638 motif II; other site 515622002639 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 515622002640 nucleotide binding site/active site [active] 515622002641 HIT family signature motif; other site 515622002642 catalytic residue [active] 515622002643 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 515622002644 catalytic core [active] 515622002645 EDD domain protein, DegV family; Region: DegV; TIGR00762 515622002646 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 515622002647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622002648 active site 515622002649 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 515622002650 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 515622002651 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 515622002652 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 515622002653 dimerization interface [polypeptide binding]; other site 515622002654 putative ATP binding site [chemical binding]; other site 515622002655 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 515622002656 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 515622002657 active site 515622002658 substrate binding site [chemical binding]; other site 515622002659 cosubstrate binding site; other site 515622002660 catalytic site [active] 515622002661 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 515622002662 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 515622002663 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 515622002664 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 515622002665 Bacterial SH3 domain homologues; Region: SH3b; smart00287 515622002666 Bacterial SH3 domain; Region: SH3_3; pfam08239 515622002667 Predicted transcriptional regulators [Transcription]; Region: COG1725 515622002668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 515622002669 DNA-binding site [nucleotide binding]; DNA binding site 515622002670 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 515622002671 Clp amino terminal domain; Region: Clp_N; pfam02861 515622002672 Clp amino terminal domain; Region: Clp_N; pfam02861 515622002673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622002674 Walker A motif; other site 515622002675 ATP binding site [chemical binding]; other site 515622002676 Walker B motif; other site 515622002677 arginine finger; other site 515622002678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622002679 Walker A motif; other site 515622002680 ATP binding site [chemical binding]; other site 515622002681 Walker B motif; other site 515622002682 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 515622002683 DNA repair protein RadA; Provisional; Region: PRK11823 515622002684 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 515622002685 Walker A motif/ATP binding site; other site 515622002686 ATP binding site [chemical binding]; other site 515622002687 Walker B motif; other site 515622002688 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 515622002689 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 515622002690 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 515622002691 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 515622002692 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 515622002693 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622002694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 515622002695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622002696 Coenzyme A binding pocket [chemical binding]; other site 515622002697 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 515622002698 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 515622002699 serine O-acetyltransferase; Region: cysE; TIGR01172 515622002700 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 515622002701 trimer interface [polypeptide binding]; other site 515622002702 active site 515622002703 substrate binding site [chemical binding]; other site 515622002704 CoA binding site [chemical binding]; other site 515622002705 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 515622002706 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 515622002707 FMN binding site [chemical binding]; other site 515622002708 active site 515622002709 catalytic residues [active] 515622002710 substrate binding site [chemical binding]; other site 515622002711 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 515622002712 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 515622002713 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 515622002714 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 515622002715 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 515622002716 Catalytic site [active] 515622002717 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 515622002718 domain interaction interfaces [polypeptide binding]; other site 515622002719 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 515622002720 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 515622002721 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 515622002722 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 515622002723 active site 515622002724 catalytic site [active] 515622002725 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 515622002726 domain interaction interfaces [polypeptide binding]; other site 515622002727 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 515622002728 active site 515622002729 catalytic site [active] 515622002730 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 515622002731 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 515622002732 active site 515622002733 metal binding site [ion binding]; metal-binding site 515622002734 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 515622002735 active site 515622002736 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 515622002737 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 515622002738 Cupin domain; Region: Cupin_2; cl17218 515622002739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622002740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622002741 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 515622002742 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515622002743 Walker A/P-loop; other site 515622002744 ATP binding site [chemical binding]; other site 515622002745 Q-loop/lid; other site 515622002746 ABC transporter signature motif; other site 515622002747 Walker B; other site 515622002748 D-loop; other site 515622002749 H-loop/switch region; other site 515622002750 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515622002751 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515622002752 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622002753 TM-ABC transporter signature motif; other site 515622002754 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622002755 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 515622002756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622002757 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515622002758 TM-ABC transporter signature motif; other site 515622002759 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 515622002760 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515622002761 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 515622002762 beta-phosphoglucomutase; Region: bPGM; TIGR01990 515622002763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622002764 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622002765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622002766 metal binding site [ion binding]; metal-binding site 515622002767 active site 515622002768 I-site; other site 515622002769 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622002770 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 515622002771 Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154 515622002772 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 515622002773 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622002774 Zn2+ binding site [ion binding]; other site 515622002775 Mg2+ binding site [ion binding]; other site 515622002776 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 515622002777 DNA primase; Validated; Region: dnaG; PRK05667 515622002778 CHC2 zinc finger; Region: zf-CHC2; pfam01807 515622002779 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 515622002780 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 515622002781 active site 515622002782 metal binding site [ion binding]; metal-binding site 515622002783 interdomain interaction site; other site 515622002784 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 515622002785 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 515622002786 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 515622002787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515622002788 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 515622002789 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515622002790 DNA binding residues [nucleotide binding] 515622002791 Family of unknown function (DUF633); Region: DUF633; pfam04816 515622002792 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 515622002793 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 515622002794 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 515622002795 active site 515622002796 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622002797 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622002798 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622002799 metal binding site [ion binding]; metal-binding site 515622002800 active site 515622002801 I-site; other site 515622002802 von Willebrand factor; Region: vWF_A; pfam12450 515622002803 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 515622002804 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 515622002805 metal ion-dependent adhesion site (MIDAS); other site 515622002806 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 515622002807 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 515622002808 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515622002809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515622002810 DNA binding residues [nucleotide binding] 515622002811 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 515622002812 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 515622002813 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 515622002814 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 515622002815 NADP binding site [chemical binding]; other site 515622002816 homodimer interface [polypeptide binding]; other site 515622002817 active site 515622002818 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 515622002819 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 515622002820 active site 515622002821 intersubunit interface [polypeptide binding]; other site 515622002822 catalytic residue [active] 515622002823 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 515622002824 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 515622002825 substrate binding site [chemical binding]; other site 515622002826 ATP binding site [chemical binding]; other site 515622002827 CBD_II domain; Region: CBD_II; smart00637 515622002828 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515622002829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622002830 Zn2+ binding site [ion binding]; other site 515622002831 Mg2+ binding site [ion binding]; other site 515622002832 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622002833 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622002834 DNA binding site [nucleotide binding] 515622002835 domain linker motif; other site 515622002836 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622002837 dimerization interface [polypeptide binding]; other site 515622002838 ligand binding site [chemical binding]; other site 515622002839 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622002840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622002841 dimer interface [polypeptide binding]; other site 515622002842 conserved gate region; other site 515622002843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 515622002844 ABC-ATPase subunit interface; other site 515622002845 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622002846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622002847 dimer interface [polypeptide binding]; other site 515622002848 ABC-ATPase subunit interface; other site 515622002849 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622002850 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 515622002851 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 515622002852 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 515622002853 Predicted transcriptional regulator [Transcription]; Region: COG3655 515622002854 Beta-lactamase; Region: Beta-lactamase; pfam00144 515622002855 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 515622002856 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 515622002857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622002858 S-adenosylmethionine binding site [chemical binding]; other site 515622002859 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 515622002860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 515622002861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515622002862 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 515622002863 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 515622002864 dimerization interface 3.5A [polypeptide binding]; other site 515622002865 active site 515622002866 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 515622002867 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 515622002868 NodB motif; other site 515622002869 active site 515622002870 catalytic site [active] 515622002871 Zn binding site [ion binding]; other site 515622002872 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 515622002873 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 515622002874 putative nucleotide binding site [chemical binding]; other site 515622002875 uridine monophosphate binding site [chemical binding]; other site 515622002876 homohexameric interface [polypeptide binding]; other site 515622002877 ribosome recycling factor; Reviewed; Region: frr; PRK00083 515622002878 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 515622002879 hinge region; other site 515622002880 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 515622002881 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 515622002882 catalytic residue [active] 515622002883 putative FPP diphosphate binding site; other site 515622002884 putative FPP binding hydrophobic cleft; other site 515622002885 dimer interface [polypeptide binding]; other site 515622002886 putative IPP diphosphate binding site; other site 515622002887 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 515622002888 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 515622002889 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 515622002890 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 515622002891 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 515622002892 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 515622002893 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 515622002894 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 515622002895 active site 515622002896 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 515622002897 protein binding site [polypeptide binding]; other site 515622002898 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 515622002899 putative substrate binding region [chemical binding]; other site 515622002900 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 515622002901 GcpE protein; Region: GcpE; pfam04551 515622002902 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 515622002903 DNA polymerase III PolC; Validated; Region: polC; PRK00448 515622002904 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 515622002905 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 515622002906 generic binding surface II; other site 515622002907 generic binding surface I; other site 515622002908 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 515622002909 active site 515622002910 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 515622002911 active site 515622002912 catalytic site [active] 515622002913 substrate binding site [chemical binding]; other site 515622002914 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 515622002915 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 515622002916 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 515622002917 active site 515622002918 Sm and related proteins; Region: Sm_like; cl00259 515622002919 ribosome maturation protein RimP; Reviewed; Region: PRK00092 515622002920 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 515622002921 putative oligomer interface [polypeptide binding]; other site 515622002922 putative RNA binding site [nucleotide binding]; other site 515622002923 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 515622002924 NusA N-terminal domain; Region: NusA_N; pfam08529 515622002925 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 515622002926 RNA binding site [nucleotide binding]; other site 515622002927 homodimer interface [polypeptide binding]; other site 515622002928 NusA-like KH domain; Region: KH_5; pfam13184 515622002929 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 515622002930 G-X-X-G motif; other site 515622002931 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 515622002932 putative RNA binding cleft [nucleotide binding]; other site 515622002933 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 515622002934 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 515622002935 translation initiation factor IF-2; Region: IF-2; TIGR00487 515622002936 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 515622002937 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 515622002938 G1 box; other site 515622002939 putative GEF interaction site [polypeptide binding]; other site 515622002940 GTP/Mg2+ binding site [chemical binding]; other site 515622002941 Switch I region; other site 515622002942 G2 box; other site 515622002943 G3 box; other site 515622002944 Switch II region; other site 515622002945 G4 box; other site 515622002946 G5 box; other site 515622002947 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 515622002948 Translation-initiation factor 2; Region: IF-2; pfam11987 515622002949 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 515622002950 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 515622002951 DHH family; Region: DHH; pfam01368 515622002952 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 515622002953 DHHA1 domain; Region: DHHA1; pfam02272 515622002954 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 515622002955 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 515622002956 RNA binding site [nucleotide binding]; other site 515622002957 active site 515622002958 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 515622002959 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 515622002960 active site 515622002961 Riboflavin kinase; Region: Flavokinase; pfam01687 515622002962 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 515622002963 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 515622002964 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 515622002965 16S/18S rRNA binding site [nucleotide binding]; other site 515622002966 S13e-L30e interaction site [polypeptide binding]; other site 515622002967 25S rRNA binding site [nucleotide binding]; other site 515622002968 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 515622002969 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 515622002970 RNase E interface [polypeptide binding]; other site 515622002971 trimer interface [polypeptide binding]; other site 515622002972 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 515622002973 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 515622002974 RNase E interface [polypeptide binding]; other site 515622002975 trimer interface [polypeptide binding]; other site 515622002976 active site 515622002977 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 515622002978 putative nucleic acid binding region [nucleotide binding]; other site 515622002979 G-X-X-G motif; other site 515622002980 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 515622002981 RNA binding site [nucleotide binding]; other site 515622002982 domain interface; other site 515622002983 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 515622002984 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 515622002985 G1 box; other site 515622002986 putative GEF interaction site [polypeptide binding]; other site 515622002987 GTP/Mg2+ binding site [chemical binding]; other site 515622002988 Switch I region; other site 515622002989 G2 box; other site 515622002990 G3 box; other site 515622002991 Switch II region; other site 515622002992 G4 box; other site 515622002993 G5 box; other site 515622002994 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 515622002995 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 515622002996 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 515622002997 Asp23 family; Region: Asp23; pfam03780 515622002998 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 515622002999 putative RNA binding site [nucleotide binding]; other site 515622003000 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 515622003001 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 515622003002 generic binding surface II; other site 515622003003 generic binding surface I; other site 515622003004 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 515622003005 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 515622003006 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 515622003007 substrate binding pocket [chemical binding]; other site 515622003008 chain length determination region; other site 515622003009 substrate-Mg2+ binding site; other site 515622003010 catalytic residues [active] 515622003011 aspartate-rich region 1; other site 515622003012 active site lid residues [active] 515622003013 aspartate-rich region 2; other site 515622003014 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 515622003015 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 515622003016 TPP-binding site; other site 515622003017 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 515622003018 PYR/PP interface [polypeptide binding]; other site 515622003019 dimer interface [polypeptide binding]; other site 515622003020 TPP binding site [chemical binding]; other site 515622003021 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515622003022 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 515622003023 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515622003024 RNA binding surface [nucleotide binding]; other site 515622003025 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 515622003026 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 515622003027 ATP-NAD kinase; Region: NAD_kinase; pfam01513 515622003028 arginine repressor; Provisional; Region: argR; PRK00441 515622003029 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 515622003030 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 515622003031 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 515622003032 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 515622003033 Walker A/P-loop; other site 515622003034 ATP binding site [chemical binding]; other site 515622003035 Q-loop/lid; other site 515622003036 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 515622003037 ABC transporter signature motif; other site 515622003038 Walker B; other site 515622003039 D-loop; other site 515622003040 H-loop/switch region; other site 515622003041 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 515622003042 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 515622003043 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 515622003044 Part of AAA domain; Region: AAA_19; pfam13245 515622003045 Family description; Region: UvrD_C_2; pfam13538 515622003046 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 515622003047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622003048 S-adenosylmethionine binding site [chemical binding]; other site 515622003049 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 515622003050 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 515622003051 DNA binding residues [nucleotide binding] 515622003052 dimer interface [polypeptide binding]; other site 515622003053 Methyltransferase domain; Region: Methyltransf_31; pfam13847 515622003054 Methyltransferase domain; Region: Methyltransf_12; pfam08242 515622003055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622003056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622003057 WHG domain; Region: WHG; pfam13305 515622003058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 515622003059 Coenzyme A binding pocket [chemical binding]; other site 515622003060 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 515622003061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622003062 Coenzyme A binding pocket [chemical binding]; other site 515622003063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622003064 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622003065 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 515622003066 YoaP-like; Region: YoaP; pfam14268 515622003067 RNA polymerase sigma factor; Provisional; Region: PRK12512 515622003068 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 515622003069 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622003070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622003071 Walker A/P-loop; other site 515622003072 ATP binding site [chemical binding]; other site 515622003073 Q-loop/lid; other site 515622003074 ABC transporter signature motif; other site 515622003075 Walker B; other site 515622003076 D-loop; other site 515622003077 H-loop/switch region; other site 515622003078 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 515622003079 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 515622003080 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 515622003081 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 515622003082 NAD(P) binding site [chemical binding]; other site 515622003083 catalytic residues [active] 515622003084 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 515622003085 Uncharacterized conserved protein [Function unknown]; Region: COG2006 515622003086 Domain of unknown function (DUF362); Region: DUF362; pfam04015 515622003087 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 515622003088 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 515622003089 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 515622003090 putative sugar binding sites [chemical binding]; other site 515622003091 Q-X-W motif; other site 515622003092 Cellulose binding domain; Region: CBM_2; pfam00553 515622003093 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 515622003094 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 515622003095 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 515622003096 Carbon starvation protein CstA; Region: CstA; pfam02554 515622003097 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 515622003098 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 515622003099 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 515622003100 dimer interface [polypeptide binding]; other site 515622003101 pyridoxal binding site [chemical binding]; other site 515622003102 ATP binding site [chemical binding]; other site 515622003103 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 515622003104 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 515622003105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622003106 FeS/SAM binding site; other site 515622003107 LrgB-like family; Region: LrgB; pfam04172 515622003108 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 515622003109 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 515622003110 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 515622003111 putative active site [active] 515622003112 putative catalytic site [active] 515622003113 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 515622003114 putative DNA binding helix; other site 515622003115 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 515622003116 metal-binding site [ion binding] 515622003117 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 515622003118 active site 515622003119 catalytic triad [active] 515622003120 oxyanion hole [active] 515622003121 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 515622003122 amidophosphoribosyltransferase; Region: purF; TIGR01134 515622003123 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 515622003124 active site 515622003125 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622003126 active site 515622003127 QueT transporter; Region: QueT; pfam06177 515622003128 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 515622003129 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 515622003130 substrate binding site [chemical binding]; other site 515622003131 multimerization interface [polypeptide binding]; other site 515622003132 ATP binding site [chemical binding]; other site 515622003133 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 515622003134 thiamine phosphate binding site [chemical binding]; other site 515622003135 active site 515622003136 pyrophosphate binding site [ion binding]; other site 515622003137 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 515622003138 dimer interface [polypeptide binding]; other site 515622003139 substrate binding site [chemical binding]; other site 515622003140 ATP binding site [chemical binding]; other site 515622003141 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 515622003142 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 515622003143 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 515622003144 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 515622003145 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 515622003146 FIST N domain; Region: FIST; smart00897 515622003147 FIST C domain; Region: FIST_C; pfam10442 515622003148 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622003149 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622003150 metal binding site [ion binding]; metal-binding site 515622003151 active site 515622003152 I-site; other site 515622003153 Predicted membrane protein [Function unknown]; Region: COG2860 515622003154 UPF0126 domain; Region: UPF0126; pfam03458 515622003155 UPF0126 domain; Region: UPF0126; pfam03458 515622003156 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 515622003157 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622003158 Coenzyme A binding pocket [chemical binding]; other site 515622003159 4Fe-4S binding domain; Region: Fer4; pfam00037 515622003160 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 515622003161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 515622003162 4Fe-4S binding domain; Region: Fer4; pfam00037 515622003163 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 515622003164 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 515622003165 active site 515622003166 substrate binding site [chemical binding]; other site 515622003167 metal binding site [ion binding]; metal-binding site 515622003168 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 515622003169 Cation efflux family; Region: Cation_efflux; cl00316 515622003170 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622003171 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622003172 dimer interface [polypeptide binding]; other site 515622003173 putative CheW interface [polypeptide binding]; other site 515622003174 Cache domain; Region: Cache_1; pfam02743 515622003175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622003176 dimerization interface [polypeptide binding]; other site 515622003177 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622003178 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622003179 dimer interface [polypeptide binding]; other site 515622003180 putative CheW interface [polypeptide binding]; other site 515622003181 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 515622003182 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 515622003183 ligand binding site; other site 515622003184 oligomer interface; other site 515622003185 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 515622003186 dimer interface [polypeptide binding]; other site 515622003187 N-terminal domain interface [polypeptide binding]; other site 515622003188 sulfate 1 binding site; other site 515622003189 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 515622003190 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 515622003191 ligand binding site; other site 515622003192 oligomer interface; other site 515622003193 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 515622003194 dimer interface [polypeptide binding]; other site 515622003195 N-terminal domain interface [polypeptide binding]; other site 515622003196 sulfate 1 binding site; other site 515622003197 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 515622003198 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622003199 metal binding site [ion binding]; metal-binding site 515622003200 active site 515622003201 I-site; other site 515622003202 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622003203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622003204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622003205 dimer interface [polypeptide binding]; other site 515622003206 phosphorylation site [posttranslational modification] 515622003207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622003208 ATP binding site [chemical binding]; other site 515622003209 Mg2+ binding site [ion binding]; other site 515622003210 G-X-G motif; other site 515622003211 Response regulator receiver domain; Region: Response_reg; pfam00072 515622003212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622003213 active site 515622003214 phosphorylation site [posttranslational modification] 515622003215 intermolecular recognition site; other site 515622003216 dimerization interface [polypeptide binding]; other site 515622003217 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 515622003218 putative binding surface; other site 515622003219 active site 515622003220 Response regulator receiver domain; Region: Response_reg; pfam00072 515622003221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622003222 active site 515622003223 phosphorylation site [posttranslational modification] 515622003224 intermolecular recognition site; other site 515622003225 dimerization interface [polypeptide binding]; other site 515622003226 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622003227 metal binding site [ion binding]; metal-binding site 515622003228 active site 515622003229 I-site; other site 515622003230 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622003231 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 515622003232 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 515622003233 Protease prsW family; Region: PrsW-protease; pfam13367 515622003234 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 515622003235 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622003236 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622003237 ABC transporter; Region: ABC_tran_2; pfam12848 515622003238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622003239 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622003240 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 515622003241 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 515622003242 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 515622003243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622003244 catalytic residue [active] 515622003245 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 515622003246 dimer interface [polypeptide binding]; other site 515622003247 Citrate synthase; Region: Citrate_synt; pfam00285 515622003248 active site 515622003249 citrylCoA binding site [chemical binding]; other site 515622003250 oxalacetate/citrate binding site [chemical binding]; other site 515622003251 coenzyme A binding site [chemical binding]; other site 515622003252 catalytic triad [active] 515622003253 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 515622003254 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 515622003255 intersubunit interface [polypeptide binding]; other site 515622003256 active site 515622003257 catalytic residue [active] 515622003258 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 515622003259 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 515622003260 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 515622003261 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 515622003262 active site 515622003263 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 515622003264 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 515622003265 Domain of unknown function DUF20; Region: UPF0118; pfam01594 515622003266 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 515622003267 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 515622003268 putative catalytic site [active] 515622003269 putative phosphate binding site [ion binding]; other site 515622003270 putative metal binding site [ion binding]; other site 515622003271 6-phosphofructokinase; Provisional; Region: PRK14072 515622003272 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 515622003273 active site 515622003274 ADP/pyrophosphate binding site [chemical binding]; other site 515622003275 dimerization interface [polypeptide binding]; other site 515622003276 allosteric effector site; other site 515622003277 fructose-1,6-bisphosphate binding site; other site 515622003278 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622003279 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622003280 metal binding site [ion binding]; metal-binding site 515622003281 active site 515622003282 I-site; other site 515622003283 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 515622003284 IHF dimer interface [polypeptide binding]; other site 515622003285 IHF - DNA interface [nucleotide binding]; other site 515622003286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622003287 metal binding site [ion binding]; metal-binding site 515622003288 active site 515622003289 I-site; other site 515622003290 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622003291 EDD domain protein, DegV family; Region: DegV; TIGR00762 515622003292 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 515622003293 Transcriptional regulator [Transcription]; Region: LysR; COG0583 515622003294 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 515622003295 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 515622003296 dimerization interface [polypeptide binding]; other site 515622003297 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 515622003298 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 515622003299 HAMP domain; Region: HAMP; pfam00672 515622003300 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 515622003301 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 515622003302 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 515622003303 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 515622003304 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 515622003305 dimer interface [polypeptide binding]; other site 515622003306 motif 1; other site 515622003307 active site 515622003308 motif 2; other site 515622003309 motif 3; other site 515622003310 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 515622003311 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 515622003312 putative tRNA-binding site [nucleotide binding]; other site 515622003313 B3/4 domain; Region: B3_4; pfam03483 515622003314 tRNA synthetase B5 domain; Region: B5; smart00874 515622003315 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 515622003316 dimer interface [polypeptide binding]; other site 515622003317 motif 1; other site 515622003318 motif 3; other site 515622003319 motif 2; other site 515622003320 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 515622003321 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 515622003322 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 515622003323 oligomer interface [polypeptide binding]; other site 515622003324 putative active site [active] 515622003325 metal binding site [ion binding]; metal-binding site 515622003326 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 515622003327 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 515622003328 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 515622003329 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 515622003330 putative pectinesterase; Region: PLN02432; cl01911 515622003331 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 515622003332 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 515622003333 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 515622003334 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 515622003335 active site 515622003336 Ca binding site [ion binding]; other site 515622003337 catalytic site [active] 515622003338 Aamy_C domain; Region: Aamy_C; smart00632 515622003339 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622003340 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622003341 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622003342 dimer interface [polypeptide binding]; other site 515622003343 putative CheW interface [polypeptide binding]; other site 515622003344 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 515622003345 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 515622003346 dimer interface [polypeptide binding]; other site 515622003347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622003348 catalytic residue [active] 515622003349 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 515622003350 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 515622003351 PilZ domain; Region: PilZ; pfam07238 515622003352 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 515622003353 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 515622003354 hinge; other site 515622003355 active site 515622003356 prephenate dehydrogenase; Validated; Region: PRK08507 515622003357 prephenate dehydrogenase; Validated; Region: PRK06545 515622003358 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 515622003359 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622003360 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622003361 metal binding site [ion binding]; metal-binding site 515622003362 active site 515622003363 I-site; other site 515622003364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622003365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622003366 dimer interface [polypeptide binding]; other site 515622003367 phosphorylation site [posttranslational modification] 515622003368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622003369 ATP binding site [chemical binding]; other site 515622003370 Mg2+ binding site [ion binding]; other site 515622003371 G-X-G motif; other site 515622003372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622003373 Response regulator receiver domain; Region: Response_reg; pfam00072 515622003374 active site 515622003375 phosphorylation site [posttranslational modification] 515622003376 intermolecular recognition site; other site 515622003377 dimerization interface [polypeptide binding]; other site 515622003378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622003379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622003380 dimer interface [polypeptide binding]; other site 515622003381 phosphorylation site [posttranslational modification] 515622003382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622003383 ATP binding site [chemical binding]; other site 515622003384 Mg2+ binding site [ion binding]; other site 515622003385 G-X-G motif; other site 515622003386 Response regulator receiver domain; Region: Response_reg; pfam00072 515622003387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622003388 active site 515622003389 phosphorylation site [posttranslational modification] 515622003390 intermolecular recognition site; other site 515622003391 dimerization interface [polypeptide binding]; other site 515622003392 EDD domain protein, DegV family; Region: DegV; TIGR00762 515622003393 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 515622003394 Hpt domain; Region: Hpt; pfam01627 515622003395 putative binding surface; other site 515622003396 active site 515622003397 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 515622003398 elongation factor G; Reviewed; Region: PRK12740 515622003399 G1 box; other site 515622003400 putative GEF interaction site [polypeptide binding]; other site 515622003401 GTP/Mg2+ binding site [chemical binding]; other site 515622003402 Switch I region; other site 515622003403 G2 box; other site 515622003404 G3 box; other site 515622003405 Switch II region; other site 515622003406 G4 box; other site 515622003407 G5 box; other site 515622003408 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 515622003409 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 515622003410 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 515622003411 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622003412 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 515622003413 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 515622003414 active site 515622003415 catalytic residues [active] 515622003416 metal binding site [ion binding]; metal-binding site 515622003417 Transcriptional regulators [Transcription]; Region: FadR; COG2186 515622003418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 515622003419 DNA-binding site [nucleotide binding]; DNA binding site 515622003420 FCD domain; Region: FCD; pfam07729 515622003421 isocitrate dehydrogenase; Validated; Region: PRK08299 515622003422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622003423 non-specific DNA binding site [nucleotide binding]; other site 515622003424 salt bridge; other site 515622003425 sequence-specific DNA binding site [nucleotide binding]; other site 515622003426 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 515622003427 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 515622003428 multiple promoter invertase; Provisional; Region: mpi; PRK13413 515622003429 catalytic residues [active] 515622003430 catalytic nucleophile [active] 515622003431 Presynaptic Site I dimer interface [polypeptide binding]; other site 515622003432 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 515622003433 Synaptic Flat tetramer interface [polypeptide binding]; other site 515622003434 Synaptic Site I dimer interface [polypeptide binding]; other site 515622003435 DNA binding site [nucleotide binding] 515622003436 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622003437 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622003438 non-specific DNA binding site [nucleotide binding]; other site 515622003439 salt bridge; other site 515622003440 sequence-specific DNA binding site [nucleotide binding]; other site 515622003441 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622003442 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622003443 active site 515622003444 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622003445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622003446 active site 515622003447 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 515622003448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622003449 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622003450 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622003451 Radical SAM superfamily; Region: Radical_SAM; pfam04055 515622003452 FeS/SAM binding site; other site 515622003453 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 515622003454 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 515622003455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622003456 NAD(P) binding site [chemical binding]; other site 515622003457 active site 515622003458 Methyltransferase domain; Region: Methyltransf_23; pfam13489 515622003459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622003460 S-adenosylmethionine binding site [chemical binding]; other site 515622003461 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 515622003462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622003463 NAD(P) binding site [chemical binding]; other site 515622003464 active site 515622003465 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 515622003466 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622003467 active site 515622003468 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 515622003469 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 515622003470 substrate binding site; other site 515622003471 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 515622003472 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622003473 inhibitor-cofactor binding pocket; inhibition site 515622003474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622003475 catalytic residue [active] 515622003476 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 515622003477 nudix motif; other site 515622003478 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 515622003479 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 515622003480 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 515622003481 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 515622003482 Walker A/P-loop; other site 515622003483 ATP binding site [chemical binding]; other site 515622003484 Q-loop/lid; other site 515622003485 ABC transporter signature motif; other site 515622003486 Walker B; other site 515622003487 D-loop; other site 515622003488 H-loop/switch region; other site 515622003489 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622003490 Transposase; Region: DEDD_Tnp_IS110; pfam01548 515622003491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 515622003492 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 515622003493 stage V sporulation protein K; Region: spore_V_K; TIGR02881 515622003494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622003495 Walker A motif; other site 515622003496 ATP binding site [chemical binding]; other site 515622003497 Walker B motif; other site 515622003498 arginine finger; other site 515622003499 Transposase; Region: DEDD_Tnp_IS110; pfam01548 515622003500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 515622003501 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 515622003502 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 515622003503 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622003504 Walker A/P-loop; other site 515622003505 ATP binding site [chemical binding]; other site 515622003506 Q-loop/lid; other site 515622003507 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622003508 ABC transporter signature motif; other site 515622003509 Walker B; other site 515622003510 ABC transporter; Region: ABC_tran_2; pfam12848 515622003511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622003512 CAAX protease self-immunity; Region: Abi; pfam02517 515622003513 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 515622003514 HflK protein; Region: hflK; TIGR01933 515622003515 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 515622003516 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 515622003517 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 515622003518 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 515622003519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515622003520 catalytic residue [active] 515622003521 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 515622003522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622003523 motif II; other site 515622003524 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 515622003525 nucleotide binding site/active site [active] 515622003526 HIT family signature motif; other site 515622003527 catalytic residue [active] 515622003528 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 515622003529 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 515622003530 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 515622003531 ATP binding site [chemical binding]; other site 515622003532 active site 515622003533 substrate binding site [chemical binding]; other site 515622003534 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 515622003535 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622003536 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622003537 ABC transporter; Region: ABC_tran_2; pfam12848 515622003538 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622003539 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 515622003540 active site 515622003541 catalytic triad [active] 515622003542 Response regulator receiver domain; Region: Response_reg; pfam00072 515622003543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622003544 active site 515622003545 phosphorylation site [posttranslational modification] 515622003546 intermolecular recognition site; other site 515622003547 dimerization interface [polypeptide binding]; other site 515622003548 Hpt domain; Region: Hpt; pfam01627 515622003549 putative binding surface; other site 515622003550 active site 515622003551 EDD domain protein, DegV family; Region: DegV; TIGR00762 515622003552 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 515622003553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515622003554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515622003555 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 515622003556 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 515622003557 active site 515622003558 catalytic site [active] 515622003559 pyruvate phosphate dikinase; Provisional; Region: PRK09279 515622003560 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 515622003561 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 515622003562 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 515622003563 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 515622003564 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622003565 dimerization interface [polypeptide binding]; other site 515622003566 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622003567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622003568 dimer interface [polypeptide binding]; other site 515622003569 putative CheW interface [polypeptide binding]; other site 515622003570 Protein of unknown function (DUF342); Region: DUF342; pfam03961 515622003571 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 515622003572 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 515622003573 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 515622003574 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 515622003575 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 515622003576 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 515622003577 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 515622003578 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 515622003579 beta subunit interaction interface [polypeptide binding]; other site 515622003580 Walker A motif; other site 515622003581 ATP binding site [chemical binding]; other site 515622003582 Walker B motif; other site 515622003583 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 515622003584 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 515622003585 core domain interface [polypeptide binding]; other site 515622003586 delta subunit interface [polypeptide binding]; other site 515622003587 epsilon subunit interface [polypeptide binding]; other site 515622003588 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 515622003589 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 515622003590 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 515622003591 alpha subunit interaction interface [polypeptide binding]; other site 515622003592 Walker A motif; other site 515622003593 ATP binding site [chemical binding]; other site 515622003594 Walker B motif; other site 515622003595 inhibitor binding site; inhibition site 515622003596 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 515622003597 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 515622003598 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 515622003599 gamma subunit interface [polypeptide binding]; other site 515622003600 epsilon subunit interface [polypeptide binding]; other site 515622003601 LBP interface [polypeptide binding]; other site 515622003602 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 515622003603 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 515622003604 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 515622003605 substrate binding pocket [chemical binding]; other site 515622003606 dimer interface [polypeptide binding]; other site 515622003607 inhibitor binding site; inhibition site 515622003608 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 515622003609 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 515622003610 B12 binding site [chemical binding]; other site 515622003611 cobalt ligand [ion binding]; other site 515622003612 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 515622003613 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 515622003614 PYR/PP interface [polypeptide binding]; other site 515622003615 dimer interface [polypeptide binding]; other site 515622003616 TPP binding site [chemical binding]; other site 515622003617 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 515622003618 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 515622003619 TPP-binding site [chemical binding]; other site 515622003620 dimer interface [polypeptide binding]; other site 515622003621 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 515622003622 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 515622003623 putative valine binding site [chemical binding]; other site 515622003624 dimer interface [polypeptide binding]; other site 515622003625 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 515622003626 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 515622003627 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 515622003628 ligand binding site [chemical binding]; other site 515622003629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622003630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622003631 dimerization interface [polypeptide binding]; other site 515622003632 Histidine kinase; Region: His_kinase; pfam06580 515622003633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622003634 ATP binding site [chemical binding]; other site 515622003635 Mg2+ binding site [ion binding]; other site 515622003636 G-X-G motif; other site 515622003637 Response regulator receiver domain; Region: Response_reg; pfam00072 515622003638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622003639 active site 515622003640 phosphorylation site [posttranslational modification] 515622003641 intermolecular recognition site; other site 515622003642 dimerization interface [polypeptide binding]; other site 515622003643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622003644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622003645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622003646 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 515622003647 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 515622003648 putative ligand binding site [chemical binding]; other site 515622003649 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 515622003650 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 515622003651 putative ligand binding site [chemical binding]; other site 515622003652 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 515622003653 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515622003654 Walker A/P-loop; other site 515622003655 ATP binding site [chemical binding]; other site 515622003656 Q-loop/lid; other site 515622003657 ABC transporter signature motif; other site 515622003658 Walker B; other site 515622003659 D-loop; other site 515622003660 H-loop/switch region; other site 515622003661 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515622003662 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515622003663 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515622003664 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622003665 TM-ABC transporter signature motif; other site 515622003666 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 515622003667 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622003668 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 515622003669 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 515622003670 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 515622003671 GGGtGRT protein; Region: GGGtGRT; pfam14057 515622003672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 515622003673 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 515622003674 GAF domain; Region: GAF; pfam01590 515622003675 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622003676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622003677 metal binding site [ion binding]; metal-binding site 515622003678 active site 515622003679 I-site; other site 515622003680 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622003681 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622003682 metal binding site [ion binding]; metal-binding site 515622003683 active site 515622003684 I-site; other site 515622003685 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 515622003686 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 515622003687 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 515622003688 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622003689 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 515622003690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622003691 Walker A/P-loop; other site 515622003692 ATP binding site [chemical binding]; other site 515622003693 Q-loop/lid; other site 515622003694 ABC transporter signature motif; other site 515622003695 Walker B; other site 515622003696 D-loop; other site 515622003697 H-loop/switch region; other site 515622003698 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622003699 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622003700 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 515622003701 Walker A/P-loop; other site 515622003702 ATP binding site [chemical binding]; other site 515622003703 Q-loop/lid; other site 515622003704 ABC transporter signature motif; other site 515622003705 Walker B; other site 515622003706 D-loop; other site 515622003707 H-loop/switch region; other site 515622003708 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 515622003709 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 515622003710 active site 515622003711 metal binding site [ion binding]; metal-binding site 515622003712 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 515622003713 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 515622003714 oligomerisation interface [polypeptide binding]; other site 515622003715 mobile loop; other site 515622003716 roof hairpin; other site 515622003717 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 515622003718 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 515622003719 ring oligomerisation interface [polypeptide binding]; other site 515622003720 ATP/Mg binding site [chemical binding]; other site 515622003721 stacking interactions; other site 515622003722 hinge regions; other site 515622003723 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 515622003724 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 515622003725 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 515622003726 homodimer interface [polypeptide binding]; other site 515622003727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622003728 catalytic residue [active] 515622003729 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 515622003730 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 515622003731 spermidine synthase; Provisional; Region: PRK00811 515622003732 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 515622003733 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 515622003734 NAD(P) binding pocket [chemical binding]; other site 515622003735 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 515622003736 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 515622003737 dimer interface [polypeptide binding]; other site 515622003738 active site 515622003739 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 515622003740 catalytic residues [active] 515622003741 substrate binding site [chemical binding]; other site 515622003742 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 515622003743 agmatine deiminase; Region: agmatine_aguA; TIGR03380 515622003744 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 515622003745 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 515622003746 putative active site; other site 515622003747 catalytic triad [active] 515622003748 putative dimer interface [polypeptide binding]; other site 515622003749 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 515622003750 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 515622003751 dimerization interface [polypeptide binding]; other site 515622003752 domain crossover interface; other site 515622003753 redox-dependent activation switch; other site 515622003754 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 515622003755 active site 515622003756 catalytic triad [active] 515622003757 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 515622003758 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 515622003759 Interdomain contacts; other site 515622003760 Cytokine receptor motif; other site 515622003761 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 515622003762 metal binding site [ion binding]; metal-binding site 515622003763 active site 515622003764 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 515622003765 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 515622003766 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622003767 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622003768 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622003769 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622003770 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622003771 dimer interface [polypeptide binding]; other site 515622003772 putative CheW interface [polypeptide binding]; other site 515622003773 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 515622003774 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 515622003775 CoA binding domain; Region: CoA_binding; smart00881 515622003776 Uncharacterized conserved protein [Function unknown]; Region: COG0062 515622003777 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 515622003778 putative substrate binding site [chemical binding]; other site 515622003779 putative ATP binding site [chemical binding]; other site 515622003780 alanine racemase; Reviewed; Region: alr; PRK00053 515622003781 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 515622003782 active site 515622003783 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 515622003784 dimer interface [polypeptide binding]; other site 515622003785 substrate binding site [chemical binding]; other site 515622003786 catalytic residues [active] 515622003787 chaperone protein DnaJ; Provisional; Region: PRK14277 515622003788 RyR domain; Region: RyR; pfam02026 515622003789 Domain of unknown function DUF21; Region: DUF21; pfam01595 515622003790 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 515622003791 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 515622003792 Transporter associated domain; Region: CorC_HlyC; pfam03471 515622003793 hypothetical protein; Validated; Region: PRK00110 515622003794 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 515622003795 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 515622003796 Peptidase M16C associated; Region: M16C_assoc; pfam08367 515622003797 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 515622003798 GTPase [General function prediction only]; Region: Era; COG1159 515622003799 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 515622003800 G1 box; other site 515622003801 GTP/Mg2+ binding site [chemical binding]; other site 515622003802 Switch I region; other site 515622003803 G2 box; other site 515622003804 Switch II region; other site 515622003805 G3 box; other site 515622003806 G4 box; other site 515622003807 G5 box; other site 515622003808 KH domain; Region: KH_2; pfam07650 515622003809 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 515622003810 Recombination protein O N terminal; Region: RecO_N; pfam11967 515622003811 Recombination protein O C terminal; Region: RecO_C; pfam02565 515622003812 glycyl-tRNA synthetase; Provisional; Region: PRK04173 515622003813 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 515622003814 motif 1; other site 515622003815 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 515622003816 active site 515622003817 motif 2; other site 515622003818 motif 3; other site 515622003819 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 515622003820 anticodon binding site; other site 515622003821 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 515622003822 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 515622003823 motif 1; other site 515622003824 active site 515622003825 motif 2; other site 515622003826 motif 3; other site 515622003827 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 515622003828 DHHA1 domain; Region: DHHA1; pfam02272 515622003829 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 515622003830 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 515622003831 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 515622003832 putative active site [active] 515622003833 putative metal binding site [ion binding]; other site 515622003834 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 515622003835 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 515622003836 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 515622003837 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 515622003838 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 515622003839 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 515622003840 carboxyltransferase (CT) interaction site; other site 515622003841 biotinylation site [posttranslational modification]; other site 515622003842 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 515622003843 oxaloacetate decarboxylase; Provisional; Region: PRK12331 515622003844 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 515622003845 active site 515622003846 catalytic residues [active] 515622003847 metal binding site [ion binding]; metal-binding site 515622003848 homodimer binding site [polypeptide binding]; other site 515622003849 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 515622003850 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 515622003851 putative active site [active] 515622003852 putative NTP binding site [chemical binding]; other site 515622003853 putative nucleic acid binding site [nucleotide binding]; other site 515622003854 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 515622003855 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 515622003856 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 515622003857 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 515622003858 active site 515622003859 catalytic site [active] 515622003860 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622003861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622003862 active site 515622003863 phosphorylation site [posttranslational modification] 515622003864 intermolecular recognition site; other site 515622003865 dimerization interface [polypeptide binding]; other site 515622003866 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622003867 DNA binding site [nucleotide binding] 515622003868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622003869 dimer interface [polypeptide binding]; other site 515622003870 phosphorylation site [posttranslational modification] 515622003871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622003872 ATP binding site [chemical binding]; other site 515622003873 Mg2+ binding site [ion binding]; other site 515622003874 G-X-G motif; other site 515622003875 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 515622003876 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 515622003877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622003878 active site 515622003879 phosphorylation site [posttranslational modification] 515622003880 intermolecular recognition site; other site 515622003881 dimerization interface [polypeptide binding]; other site 515622003882 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 515622003883 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 515622003884 putative active site [active] 515622003885 oxyanion strand; other site 515622003886 catalytic triad [active] 515622003887 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 515622003888 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 515622003889 substrate binding site [chemical binding]; other site 515622003890 glutamase interaction surface [polypeptide binding]; other site 515622003891 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 515622003892 ligand binding site [chemical binding]; other site 515622003893 active site 515622003894 UGI interface [polypeptide binding]; other site 515622003895 catalytic site [active] 515622003896 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 515622003897 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 515622003898 active site 515622003899 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 515622003900 substrate binding site [chemical binding]; other site 515622003901 catalytic residues [active] 515622003902 dimer interface [polypeptide binding]; other site 515622003903 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 515622003904 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622003905 active site 515622003906 DNA binding site [nucleotide binding] 515622003907 Int/Topo IB signature motif; other site 515622003908 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 515622003909 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 515622003910 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 515622003911 DNA binding residues [nucleotide binding] 515622003912 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 515622003913 Methyltransferase domain; Region: Methyltransf_26; pfam13659 515622003914 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 515622003915 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 515622003916 putative active site [active] 515622003917 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 515622003918 active site 515622003919 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 515622003920 CbiD; Region: CbiD; cl00828 515622003921 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 515622003922 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 515622003923 active site 515622003924 HIGH motif; other site 515622003925 dimer interface [polypeptide binding]; other site 515622003926 KMSKS motif; other site 515622003927 glycogen synthase; Provisional; Region: glgA; PRK00654 515622003928 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 515622003929 ADP-binding pocket [chemical binding]; other site 515622003930 homodimer interface [polypeptide binding]; other site 515622003931 stage V sporulation protein B; Region: spore_V_B; TIGR02900 515622003932 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 515622003933 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 515622003934 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 515622003935 putative oligomer interface [polypeptide binding]; other site 515622003936 putative active site [active] 515622003937 metal binding site [ion binding]; metal-binding site 515622003938 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622003939 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622003940 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 515622003941 Walker A/P-loop; other site 515622003942 ATP binding site [chemical binding]; other site 515622003943 Q-loop/lid; other site 515622003944 ABC transporter signature motif; other site 515622003945 Walker B; other site 515622003946 D-loop; other site 515622003947 H-loop/switch region; other site 515622003948 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 515622003949 Domain of unknown function (DUF814); Region: DUF814; pfam05670 515622003950 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 515622003951 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 515622003952 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 515622003953 DNA binding residues [nucleotide binding] 515622003954 acyl carrier protein; Provisional; Region: acpP; PRK00982 515622003955 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 515622003956 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 515622003957 FMN binding site [chemical binding]; other site 515622003958 substrate binding site [chemical binding]; other site 515622003959 putative catalytic residue [active] 515622003960 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 515622003961 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 515622003962 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 515622003963 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 515622003964 NAD(P) binding site [chemical binding]; other site 515622003965 homotetramer interface [polypeptide binding]; other site 515622003966 homodimer interface [polypeptide binding]; other site 515622003967 active site 515622003968 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 515622003969 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 515622003970 dimer interface [polypeptide binding]; other site 515622003971 active site 515622003972 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 515622003973 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 515622003974 carboxyltransferase (CT) interaction site; other site 515622003975 biotinylation site [posttranslational modification]; other site 515622003976 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 515622003977 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 515622003978 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515622003979 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515622003980 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 515622003981 acetyl-CoA carboxylase beta subunit; Reviewed; Region: accD; CHL00174 515622003982 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 515622003983 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 515622003984 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 515622003985 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 515622003986 acyl-activating enzyme (AAE) consensus motif; other site 515622003987 AMP binding site [chemical binding]; other site 515622003988 active site 515622003989 CoA binding site [chemical binding]; other site 515622003990 altronate oxidoreductase; Provisional; Region: PRK03643 515622003991 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 515622003992 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 515622003993 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 515622003994 peptide binding site [polypeptide binding]; other site 515622003995 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 515622003996 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515622003997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622003998 dimer interface [polypeptide binding]; other site 515622003999 conserved gate region; other site 515622004000 putative PBP binding loops; other site 515622004001 ABC-ATPase subunit interface; other site 515622004002 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515622004003 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 515622004004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622004005 dimer interface [polypeptide binding]; other site 515622004006 conserved gate region; other site 515622004007 ABC-ATPase subunit interface; other site 515622004008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622004009 Walker A/P-loop; other site 515622004010 ATP binding site [chemical binding]; other site 515622004011 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 515622004012 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515622004013 Q-loop/lid; other site 515622004014 ABC transporter signature motif; other site 515622004015 Walker B; other site 515622004016 D-loop; other site 515622004017 H-loop/switch region; other site 515622004018 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515622004019 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 515622004020 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515622004021 Walker A/P-loop; other site 515622004022 ATP binding site [chemical binding]; other site 515622004023 Q-loop/lid; other site 515622004024 ABC transporter signature motif; other site 515622004025 Walker B; other site 515622004026 D-loop; other site 515622004027 H-loop/switch region; other site 515622004028 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 515622004029 hypothetical protein; Provisional; Region: PRK11820 515622004030 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 515622004031 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 515622004032 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 515622004033 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 515622004034 catalytic site [active] 515622004035 G-X2-G-X-G-K; other site 515622004036 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 515622004037 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 515622004038 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 515622004039 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622004040 FeS/SAM binding site; other site 515622004041 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 515622004042 helicase 45; Provisional; Region: PTZ00424 515622004043 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 515622004044 ATP binding site [chemical binding]; other site 515622004045 Mg++ binding site [ion binding]; other site 515622004046 motif III; other site 515622004047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515622004048 nucleotide binding region [chemical binding]; other site 515622004049 ATP-binding site [chemical binding]; other site 515622004050 Ion transport protein; Region: Ion_trans; pfam00520 515622004051 Ion channel; Region: Ion_trans_2; pfam07885 515622004052 TrkA-C domain; Region: TrkA_C; pfam02080 515622004053 TrkA-C domain; Region: TrkA_C; pfam02080 515622004054 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 515622004055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622004056 active site 515622004057 motif I; other site 515622004058 motif II; other site 515622004059 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 515622004060 hypothetical protein; Provisional; Region: PRK09273 515622004061 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 515622004062 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 515622004063 TPR repeat; Region: TPR_11; pfam13414 515622004064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622004065 TPR motif; other site 515622004066 Thiamine pyrophosphokinase; Region: TPK; cd07995 515622004067 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 515622004068 active site 515622004069 dimerization interface [polypeptide binding]; other site 515622004070 thiamine binding site [chemical binding]; other site 515622004071 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 515622004072 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 515622004073 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 515622004074 phosphoglyceromutase; Provisional; Region: PRK05434 515622004075 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 515622004076 Preprotein translocase SecG subunit; Region: SecG; pfam03840 515622004077 ribonuclease R; Region: RNase_R; TIGR02063 515622004078 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 515622004079 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 515622004080 RNB domain; Region: RNB; pfam00773 515622004081 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 515622004082 RNA binding site [nucleotide binding]; other site 515622004083 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 515622004084 SmpB-tmRNA interface; other site 515622004085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 515622004086 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622004087 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622004088 dimer interface [polypeptide binding]; other site 515622004089 putative CheW interface [polypeptide binding]; other site 515622004090 gamma-glutamyl kinase; Provisional; Region: PRK05429 515622004091 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 515622004092 nucleotide binding site [chemical binding]; other site 515622004093 homotetrameric interface [polypeptide binding]; other site 515622004094 putative phosphate binding site [ion binding]; other site 515622004095 putative allosteric binding site; other site 515622004096 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 515622004097 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 515622004098 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 515622004099 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 515622004100 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 515622004101 Potassium binding sites [ion binding]; other site 515622004102 Cesium cation binding sites [ion binding]; other site 515622004103 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 515622004104 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 515622004105 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 515622004106 homodimer interface [polypeptide binding]; other site 515622004107 NADP binding site [chemical binding]; other site 515622004108 substrate binding site [chemical binding]; other site 515622004109 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 515622004110 Double zinc ribbon; Region: DZR; pfam12773 515622004111 TPR repeat; Region: TPR_11; pfam13414 515622004112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622004113 binding surface 515622004114 TPR motif; other site 515622004115 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 515622004116 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C_1; pfam13290 515622004117 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 515622004118 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 515622004119 FAD binding pocket [chemical binding]; other site 515622004120 FAD binding motif [chemical binding]; other site 515622004121 phosphate binding motif [ion binding]; other site 515622004122 beta-alpha-beta structure motif; other site 515622004123 NAD binding pocket [chemical binding]; other site 515622004124 Iron coordination center [ion binding]; other site 515622004125 putative oxidoreductase; Provisional; Region: PRK12831 515622004126 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 515622004127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 515622004128 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 515622004129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515622004130 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 515622004131 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 515622004132 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 515622004133 PhoH-like protein; Region: PhoH; pfam02562 515622004134 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 515622004135 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 515622004136 metal-binding heat shock protein; Provisional; Region: PRK00016 515622004137 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 515622004138 flavoprotein, HI0933 family; Region: TIGR00275 515622004139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 515622004140 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 515622004141 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 515622004142 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 515622004143 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622004144 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622004145 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622004146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622004147 dimer interface [polypeptide binding]; other site 515622004148 conserved gate region; other site 515622004149 putative PBP binding loops; other site 515622004150 ABC-ATPase subunit interface; other site 515622004151 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622004152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622004153 dimer interface [polypeptide binding]; other site 515622004154 conserved gate region; other site 515622004155 putative PBP binding loops; other site 515622004156 ABC-ATPase subunit interface; other site 515622004157 Predicted membrane protein [Function unknown]; Region: COG2364 515622004158 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 515622004159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622004160 dimerization interface [polypeptide binding]; other site 515622004161 Histidine kinase; Region: His_kinase; pfam06580 515622004162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622004163 ATP binding site [chemical binding]; other site 515622004164 Mg2+ binding site [ion binding]; other site 515622004165 G-X-G motif; other site 515622004166 Response regulator receiver domain; Region: Response_reg; pfam00072 515622004167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622004168 active site 515622004169 phosphorylation site [posttranslational modification] 515622004170 intermolecular recognition site; other site 515622004171 dimerization interface [polypeptide binding]; other site 515622004172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622004173 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622004174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622004175 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 515622004176 ParB-like nuclease domain; Region: ParBc; pfam02195 515622004177 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 515622004178 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 515622004179 putative catalytic cysteine [active] 515622004180 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 515622004181 intersubunit interface [polypeptide binding]; other site 515622004182 active site 515622004183 Zn2+ binding site [ion binding]; other site 515622004184 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 515622004185 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 515622004186 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 515622004187 active site 515622004188 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 515622004189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 515622004190 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515622004191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622004192 dimer interface [polypeptide binding]; other site 515622004193 conserved gate region; other site 515622004194 putative PBP binding loops; other site 515622004195 ABC-ATPase subunit interface; other site 515622004196 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 515622004197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622004198 dimer interface [polypeptide binding]; other site 515622004199 conserved gate region; other site 515622004200 putative PBP binding loops; other site 515622004201 ABC-ATPase subunit interface; other site 515622004202 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 515622004203 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 515622004204 Walker A/P-loop; other site 515622004205 ATP binding site [chemical binding]; other site 515622004206 Q-loop/lid; other site 515622004207 ABC transporter signature motif; other site 515622004208 Walker B; other site 515622004209 D-loop; other site 515622004210 H-loop/switch region; other site 515622004211 TOBE domain; Region: TOBE_2; pfam08402 515622004212 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 515622004213 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 515622004214 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 515622004215 Tetramer interface [polypeptide binding]; other site 515622004216 active site 515622004217 FMN-binding site [chemical binding]; other site 515622004218 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 515622004219 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 515622004220 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 515622004221 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 515622004222 Preprotein translocase subunit; Region: YajC; pfam02699 515622004223 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 515622004224 tartrate dehydrogenase; Region: TTC; TIGR02089 515622004225 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 515622004226 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 515622004227 6-phosphogluconate dehydratase; Region: edd; TIGR01196 515622004228 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 515622004229 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 515622004230 PYR/PP interface [polypeptide binding]; other site 515622004231 dimer interface [polypeptide binding]; other site 515622004232 TPP binding site [chemical binding]; other site 515622004233 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 515622004234 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 515622004235 TPP-binding site [chemical binding]; other site 515622004236 dimer interface [polypeptide binding]; other site 515622004237 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 515622004238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 515622004239 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 515622004240 homodimer interface [polypeptide binding]; other site 515622004241 substrate-cofactor binding pocket; other site 515622004242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622004243 catalytic residue [active] 515622004244 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 515622004245 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 515622004246 putative ligand binding site [chemical binding]; other site 515622004247 putative NAD binding site [chemical binding]; other site 515622004248 putative catalytic site [active] 515622004249 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 515622004250 L-serine binding site [chemical binding]; other site 515622004251 ACT domain interface; other site 515622004252 Uncharacterized conserved protein [Function unknown]; Region: COG4198 515622004253 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 515622004254 glycogen branching enzyme; Provisional; Region: PRK05402 515622004255 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 515622004256 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 515622004257 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 515622004258 active site 515622004259 catalytic site [active] 515622004260 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 515622004261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622004262 active site 515622004263 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 515622004264 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622004265 Zn2+ binding site [ion binding]; other site 515622004266 Mg2+ binding site [ion binding]; other site 515622004267 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 515622004268 synthetase active site [active] 515622004269 NTP binding site [chemical binding]; other site 515622004270 metal binding site [ion binding]; metal-binding site 515622004271 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 515622004272 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 515622004273 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 515622004274 coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994 515622004275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622004276 FeS/SAM binding site; other site 515622004277 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515622004278 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 515622004279 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 515622004280 4Fe-4S binding domain; Region: Fer4; pfam00037 515622004281 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 515622004282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 515622004283 4Fe-4S binding domain; Region: Fer4; pfam00037 515622004284 DNA topoisomerase I; Validated; Region: PRK05582 515622004285 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 515622004286 active site 515622004287 interdomain interaction site; other site 515622004288 putative metal-binding site [ion binding]; other site 515622004289 nucleotide binding site [chemical binding]; other site 515622004290 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 515622004291 domain I; other site 515622004292 DNA binding groove [nucleotide binding] 515622004293 phosphate binding site [ion binding]; other site 515622004294 domain II; other site 515622004295 domain III; other site 515622004296 nucleotide binding site [chemical binding]; other site 515622004297 catalytic site [active] 515622004298 domain IV; other site 515622004299 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 515622004300 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 515622004301 transcriptional repressor CodY; Validated; Region: PRK04158 515622004302 CodY GAF-like domain; Region: CodY; pfam06018 515622004303 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 515622004304 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 515622004305 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 515622004306 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 515622004307 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 515622004308 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 515622004309 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 515622004310 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 515622004311 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 515622004312 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 515622004313 MgtE intracellular N domain; Region: MgtE_N; cl15244 515622004314 FliG C-terminal domain; Region: FliG_C; pfam01706 515622004315 Flagellar assembly protein FliH; Region: FliH; pfam02108 515622004316 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 515622004317 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 515622004318 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 515622004319 Walker A motif/ATP binding site; other site 515622004320 Walker B motif; other site 515622004321 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 515622004322 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 515622004323 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 515622004324 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 515622004325 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 515622004326 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 515622004327 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 515622004328 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 515622004329 Putative esterase; Region: Esterase; pfam00756 515622004330 Flagellar protein (FlbD); Region: FlbD; cl00683 515622004331 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 515622004332 flagellar motor protein MotP; Reviewed; Region: PRK06926 515622004333 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 515622004334 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 515622004335 ligand binding site [chemical binding]; other site 515622004336 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 515622004337 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 515622004338 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 515622004339 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 515622004340 CheC-like family; Region: CheC; pfam04509 515622004341 CheC-like family; Region: CheC; pfam04509 515622004342 flagellar motor switch protein FliN; Region: fliN; TIGR02480 515622004343 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 515622004344 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 515622004345 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 515622004346 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 515622004347 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 515622004348 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 515622004349 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 515622004350 FHIPEP family; Region: FHIPEP; pfam00771 515622004351 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 515622004352 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515622004353 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 515622004354 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 515622004355 P-loop; other site 515622004356 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 515622004357 Flagellar protein YcgR; Region: YcgR_2; pfam12945 515622004358 PilZ domain; Region: PilZ; pfam07238 515622004359 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 515622004360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622004361 active site 515622004362 phosphorylation site [posttranslational modification] 515622004363 intermolecular recognition site; other site 515622004364 dimerization interface [polypeptide binding]; other site 515622004365 CheB methylesterase; Region: CheB_methylest; pfam01339 515622004366 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 515622004367 putative binding surface; other site 515622004368 active site 515622004369 P2 response regulator binding domain; Region: P2; pfam07194 515622004370 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 515622004371 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 515622004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622004373 ATP binding site [chemical binding]; other site 515622004374 Mg2+ binding site [ion binding]; other site 515622004375 G-X-G motif; other site 515622004376 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 515622004377 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 515622004378 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 515622004379 CheC-like family; Region: CheC; pfam04509 515622004380 CheC-like family; Region: CheC; pfam04509 515622004381 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 515622004382 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 515622004383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515622004384 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 515622004385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515622004386 DNA binding residues [nucleotide binding] 515622004387 Protein of unknown function (DUF342); Region: DUF342; pfam03961 515622004388 YceG-like family; Region: YceG; pfam02618 515622004389 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 515622004390 rRNA interaction site [nucleotide binding]; other site 515622004391 S8 interaction site; other site 515622004392 putative laminin-1 binding site; other site 515622004393 elongation factor Ts; Provisional; Region: tsf; PRK09377 515622004394 UBA/TS-N domain; Region: UBA; pfam00627 515622004395 Elongation factor TS; Region: EF_TS; pfam00889 515622004396 Elongation factor TS; Region: EF_TS; pfam00889 515622004397 septum formation inhibitor; Reviewed; Region: minC; PRK00513 515622004398 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 515622004399 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 515622004400 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 515622004401 Switch I; other site 515622004402 Switch II; other site 515622004403 Septum formation topological specificity factor MinE; Region: MinE; cl00538 515622004404 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 515622004405 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 515622004406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622004407 motif II; other site 515622004408 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 515622004409 MarR family; Region: MarR; pfam01047 515622004410 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 515622004411 putative homodimer interface [polypeptide binding]; other site 515622004412 putative homotetramer interface [polypeptide binding]; other site 515622004413 putative metal binding site [ion binding]; other site 515622004414 putative homodimer-homodimer interface [polypeptide binding]; other site 515622004415 putative allosteric switch controlling residues; other site 515622004416 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 515622004417 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 515622004418 NADH dehydrogenase; Region: NADHdh; cl00469 515622004419 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 515622004420 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 515622004421 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 515622004422 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 515622004423 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 515622004424 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 515622004425 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 515622004426 Acylphosphatase; Region: Acylphosphatase; pfam00708 515622004427 HypF finger; Region: zf-HYPF; pfam07503 515622004428 HypF finger; Region: zf-HYPF; pfam07503 515622004429 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 515622004430 HupF/HypC family; Region: HupF_HypC; pfam01455 515622004431 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 515622004432 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 515622004433 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 515622004434 dimerization interface [polypeptide binding]; other site 515622004435 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 515622004436 ATP binding site [chemical binding]; other site 515622004437 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 515622004438 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 515622004439 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515622004440 RNA binding surface [nucleotide binding]; other site 515622004441 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 515622004442 active site 515622004443 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 515622004444 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 515622004445 nucleotide binding pocket [chemical binding]; other site 515622004446 K-X-D-G motif; other site 515622004447 catalytic site [active] 515622004448 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 515622004449 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 515622004450 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 515622004451 Dimer interface [polypeptide binding]; other site 515622004452 BRCT sequence motif; other site 515622004453 Homoserine O-succinyltransferase; Region: HTS; pfam04204 515622004454 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 515622004455 proposed active site lysine [active] 515622004456 conserved cys residue [active] 515622004457 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 515622004458 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 515622004459 putative active site [active] 515622004460 putative metal binding site [ion binding]; other site 515622004461 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 515622004462 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 515622004463 active site 515622004464 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622004465 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 515622004466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 515622004467 catalytic core [active] 515622004468 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 515622004469 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 515622004470 putative active site [active] 515622004471 metal binding site [ion binding]; metal-binding site 515622004472 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 515622004473 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 515622004474 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 515622004475 ligand binding site [chemical binding]; other site 515622004476 flexible hinge region; other site 515622004477 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 515622004478 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 515622004479 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 515622004480 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622004481 active site 515622004482 Int/Topo IB signature motif; other site 515622004483 DNA binding site [nucleotide binding] 515622004484 Protein of unknown function (DUF975); Region: DUF975; cl10504 515622004485 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 515622004486 DHH family; Region: DHH; pfam01368 515622004487 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 515622004488 LexA repressor; Validated; Region: PRK00215 515622004489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515622004490 putative DNA binding site [nucleotide binding]; other site 515622004491 putative Zn2+ binding site [ion binding]; other site 515622004492 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 515622004493 Catalytic site [active] 515622004494 Oligomerisation domain; Region: Oligomerisation; pfam02410 515622004495 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622004496 Zn2+ binding site [ion binding]; other site 515622004497 Mg2+ binding site [ion binding]; other site 515622004498 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 515622004499 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 515622004500 active site 515622004501 (T/H)XGH motif; other site 515622004502 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 515622004503 GTPase CgtA; Reviewed; Region: obgE; PRK12297 515622004504 GTP1/OBG; Region: GTP1_OBG; pfam01018 515622004505 Obg GTPase; Region: Obg; cd01898 515622004506 G1 box; other site 515622004507 GTP/Mg2+ binding site [chemical binding]; other site 515622004508 Switch I region; other site 515622004509 G2 box; other site 515622004510 G3 box; other site 515622004511 Switch II region; other site 515622004512 G4 box; other site 515622004513 G5 box; other site 515622004514 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 515622004515 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 515622004516 Protein of unknown function (DUF464); Region: DUF464; pfam04327 515622004517 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 515622004518 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 515622004519 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 515622004520 RNA binding site [nucleotide binding]; other site 515622004521 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 515622004522 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 515622004523 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 515622004524 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 515622004525 B12 binding site [chemical binding]; other site 515622004526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622004527 FeS/SAM binding site; other site 515622004528 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 515622004529 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 515622004530 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 515622004531 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 515622004532 metal binding site [ion binding]; metal-binding site 515622004533 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 515622004534 putative active site pocket [active] 515622004535 4-fold oligomerization interface [polypeptide binding]; other site 515622004536 metal binding residues [ion binding]; metal-binding site 515622004537 3-fold/trimer interface [polypeptide binding]; other site 515622004538 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 515622004539 histidinol dehydrogenase; Region: hisD; TIGR00069 515622004540 NAD binding site [chemical binding]; other site 515622004541 dimerization interface [polypeptide binding]; other site 515622004542 product binding site; other site 515622004543 substrate binding site [chemical binding]; other site 515622004544 zinc binding site [ion binding]; other site 515622004545 catalytic residues [active] 515622004546 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 515622004547 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 515622004548 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 515622004549 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 515622004550 dimer interface [polypeptide binding]; other site 515622004551 motif 1; other site 515622004552 active site 515622004553 motif 2; other site 515622004554 motif 3; other site 515622004555 Recombination protein U; Region: RecU; pfam03838 515622004556 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 515622004557 S4 RNA-binding domain; Region: S4; smart00363 515622004558 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 515622004559 active site 515622004560 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 515622004561 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515622004562 RNA binding surface [nucleotide binding]; other site 515622004563 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 515622004564 active site 515622004565 uracil binding [chemical binding]; other site 515622004566 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 515622004567 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 515622004568 active site 515622004569 metal binding site [ion binding]; metal-binding site 515622004570 V-type ATP synthase subunit E; Provisional; Region: PRK01558 515622004571 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 515622004572 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 515622004573 active site 515622004574 (T/H)XGH motif; other site 515622004575 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 515622004576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622004577 S-adenosylmethionine binding site [chemical binding]; other site 515622004578 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 515622004579 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 515622004580 CAP-like domain; other site 515622004581 active site 515622004582 primary dimer interface [polypeptide binding]; other site 515622004583 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515622004584 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 515622004585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622004586 ATP binding site [chemical binding]; other site 515622004587 Mg2+ binding site [ion binding]; other site 515622004588 G-X-G motif; other site 515622004589 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 515622004590 anchoring element; other site 515622004591 dimer interface [polypeptide binding]; other site 515622004592 ATP binding site [chemical binding]; other site 515622004593 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 515622004594 active site 515622004595 putative metal-binding site [ion binding]; other site 515622004596 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 515622004597 EDD domain protein, DegV family; Region: DegV; TIGR00762 515622004598 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 515622004599 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 515622004600 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 515622004601 generic binding surface II; other site 515622004602 ssDNA binding site; other site 515622004603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515622004604 ATP binding site [chemical binding]; other site 515622004605 putative Mg++ binding site [ion binding]; other site 515622004606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515622004607 nucleotide binding region [chemical binding]; other site 515622004608 ATP-binding site [chemical binding]; other site 515622004609 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 515622004610 DAK2 domain; Region: Dak2; pfam02734 515622004611 Asp23 family; Region: Asp23; pfam03780 515622004612 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 515622004613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515622004614 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 515622004615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515622004616 substrate binding pocket [chemical binding]; other site 515622004617 membrane-bound complex binding site; other site 515622004618 hinge residues; other site 515622004619 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 515622004620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515622004621 substrate binding pocket [chemical binding]; other site 515622004622 membrane-bound complex binding site; other site 515622004623 hinge residues; other site 515622004624 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 515622004625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622004626 active site 515622004627 phosphorylation site [posttranslational modification] 515622004628 intermolecular recognition site; other site 515622004629 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 515622004630 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 515622004631 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 515622004632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 515622004633 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 515622004634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 515622004635 major head protein; Region: PHA00144 515622004636 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 515622004637 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 515622004638 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515622004639 RNA binding surface [nucleotide binding]; other site 515622004640 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 515622004641 active site 515622004642 lipoprotein signal peptidase; Provisional; Region: PRK14767 515622004643 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 515622004644 active site 515622004645 dimer interface [polypeptide binding]; other site 515622004646 metal binding site [ion binding]; metal-binding site 515622004647 Protein of unknown function (DUF552); Region: DUF552; pfam04472 515622004648 HlyD family secretion protein; Region: HlyD_2; pfam12700 515622004649 putative membrane fusion protein; Region: TIGR02828 515622004650 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 515622004651 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 515622004652 methylglyoxal synthase; Validated; Region: mgsA; PRK05234 515622004653 substrate binding site [chemical binding]; other site 515622004654 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 515622004655 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 515622004656 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 515622004657 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 515622004658 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 515622004659 rod shape-determining protein MreC; Provisional; Region: PRK13922 515622004660 rod shape-determining protein MreC; Region: MreC; pfam04085 515622004661 MreB and similar proteins; Region: MreB_like; cd10225 515622004662 rod shape-determining protein MreB; Provisional; Region: PRK13927 515622004663 nucleotide binding site [chemical binding]; other site 515622004664 Mg binding site [ion binding]; other site 515622004665 putative protofilament interaction site [polypeptide binding]; other site 515622004666 RodZ interaction site [polypeptide binding]; other site 515622004667 hypothetical protein; Reviewed; Region: PRK00024 515622004668 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 515622004669 MPN+ (JAMM) motif; other site 515622004670 Zinc-binding site [ion binding]; other site 515622004671 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 515622004672 Aluminium resistance protein; Region: Alum_res; pfam06838 515622004673 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 515622004674 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 515622004675 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 515622004676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622004677 ATP binding site [chemical binding]; other site 515622004678 Mg2+ binding site [ion binding]; other site 515622004679 G-X-G motif; other site 515622004680 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 515622004681 ATP binding site [chemical binding]; other site 515622004682 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 515622004683 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 515622004684 MutS domain I; Region: MutS_I; pfam01624 515622004685 MutS domain II; Region: MutS_II; pfam05188 515622004686 MutS domain III; Region: MutS_III; pfam05192 515622004687 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 515622004688 Walker A/P-loop; other site 515622004689 ATP binding site [chemical binding]; other site 515622004690 Q-loop/lid; other site 515622004691 ABC transporter signature motif; other site 515622004692 Walker B; other site 515622004693 D-loop; other site 515622004694 H-loop/switch region; other site 515622004695 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 515622004696 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 515622004697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622004698 FeS/SAM binding site; other site 515622004699 TRAM domain; Region: TRAM; cl01282 515622004700 peptidase T; Region: peptidase-T; TIGR01882 515622004701 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 515622004702 metal binding site [ion binding]; metal-binding site 515622004703 dimer interface [polypeptide binding]; other site 515622004704 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 515622004705 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 515622004706 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 515622004707 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 515622004708 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 515622004709 Part of AAA domain; Region: AAA_19; pfam13245 515622004710 Family description; Region: UvrD_C_2; pfam13538 515622004711 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 515622004712 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 515622004713 active site 515622004714 HIGH motif; other site 515622004715 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 515622004716 active site 515622004717 KMSKS motif; other site 515622004718 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 515622004719 trimer interface [polypeptide binding]; other site 515622004720 active site 515622004721 Cellulose binding domain; Region: CBM_2; pfam00553 515622004722 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 515622004723 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 515622004724 endoglucanase; Region: PLN02420 515622004725 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 515622004726 Cellulose binding domain; Region: CBM_3; pfam00942 515622004727 Cellulose binding domain; Region: CBM_2; pfam00553 515622004728 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 515622004729 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 515622004730 acyl-activating enzyme (AAE) consensus motif; other site 515622004731 AMP binding site [chemical binding]; other site 515622004732 active site 515622004733 CoA binding site [chemical binding]; other site 515622004734 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 515622004735 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 515622004736 dimer interface [polypeptide binding]; other site 515622004737 PYR/PP interface [polypeptide binding]; other site 515622004738 TPP binding site [chemical binding]; other site 515622004739 substrate binding site [chemical binding]; other site 515622004740 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 515622004741 TPP-binding site; other site 515622004742 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 515622004743 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 515622004744 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 515622004745 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 515622004746 acyl-activating enzyme (AAE) consensus motif; other site 515622004747 AMP binding site [chemical binding]; other site 515622004748 active site 515622004749 CoA binding site [chemical binding]; other site 515622004750 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 515622004751 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 515622004752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 515622004753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622004754 Coenzyme A binding pocket [chemical binding]; other site 515622004755 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 515622004756 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 515622004757 Na binding site [ion binding]; other site 515622004758 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 515622004759 active site 515622004760 intersubunit interactions; other site 515622004761 catalytic residue [active] 515622004762 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 515622004763 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 515622004764 CotH protein; Region: CotH; pfam08757 515622004765 DHHW protein; Region: DHHW; pfam14286 515622004766 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 515622004767 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 515622004768 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 515622004769 DXD motif; other site 515622004770 PilZ domain; Region: PilZ; pfam07238 515622004771 CotH protein; Region: CotH; pfam08757 515622004772 MgtC family; Region: MgtC; pfam02308 515622004773 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 515622004774 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 515622004775 putative metal binding residues [ion binding]; other site 515622004776 signature motif; other site 515622004777 dimer interface [polypeptide binding]; other site 515622004778 active site 515622004779 polyP binding site; other site 515622004780 substrate binding site [chemical binding]; other site 515622004781 acceptor-phosphate pocket; other site 515622004782 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 515622004783 active site 515622004784 catalytic residues [active] 515622004785 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 515622004786 active site 515622004787 metal binding site [ion binding]; metal-binding site 515622004788 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 515622004789 RNA/DNA hybrid binding site [nucleotide binding]; other site 515622004790 active site 515622004791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622004792 Walker A/P-loop; other site 515622004793 ATP binding site [chemical binding]; other site 515622004794 Q-loop/lid; other site 515622004795 ABC transporter signature motif; other site 515622004796 Walker B; other site 515622004797 D-loop; other site 515622004798 H-loop/switch region; other site 515622004799 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 515622004800 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 515622004801 active site 515622004802 putative substrate binding pocket [chemical binding]; other site 515622004803 purine nucleoside phosphorylase; Provisional; Region: PRK08202 515622004804 Beta-lactamase; Region: Beta-lactamase; pfam00144 515622004805 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 515622004806 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 515622004807 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 515622004808 Soluble P-type ATPase [General function prediction only]; Region: COG4087 515622004809 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 515622004810 metal-binding site [ion binding] 515622004811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515622004812 dimerization interface [polypeptide binding]; other site 515622004813 putative DNA binding site [nucleotide binding]; other site 515622004814 putative Zn2+ binding site [ion binding]; other site 515622004815 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 515622004816 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 515622004817 active site 515622004818 HIGH motif; other site 515622004819 dimer interface [polypeptide binding]; other site 515622004820 KMSKS motif; other site 515622004821 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515622004822 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 515622004823 substrate binding site [chemical binding]; other site 515622004824 Protein of unknown function (DUF521); Region: DUF521; pfam04412 515622004825 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 515622004826 substrate binding site [chemical binding]; other site 515622004827 ligand binding site [chemical binding]; other site 515622004828 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 515622004829 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 515622004830 Predicted transcriptional regulators [Transcription]; Region: COG1695 515622004831 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 515622004832 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 515622004833 hypothetical protein; Provisional; Region: PRK09609 515622004834 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 515622004835 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 515622004836 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 515622004837 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 515622004838 GTP-binding protein Der; Reviewed; Region: PRK00093 515622004839 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 515622004840 G1 box; other site 515622004841 GTP/Mg2+ binding site [chemical binding]; other site 515622004842 Switch I region; other site 515622004843 G2 box; other site 515622004844 Switch II region; other site 515622004845 G3 box; other site 515622004846 G4 box; other site 515622004847 G5 box; other site 515622004848 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 515622004849 G1 box; other site 515622004850 GTP/Mg2+ binding site [chemical binding]; other site 515622004851 Switch I region; other site 515622004852 G2 box; other site 515622004853 G3 box; other site 515622004854 Switch II region; other site 515622004855 G4 box; other site 515622004856 G5 box; other site 515622004857 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 515622004858 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 515622004859 Protein of unknown function (DUF512); Region: DUF512; pfam04459 515622004860 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 515622004861 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 515622004862 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622004863 active site 515622004864 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622004865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622004866 dimer interface [polypeptide binding]; other site 515622004867 phosphorylation site [posttranslational modification] 515622004868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622004869 ATP binding site [chemical binding]; other site 515622004870 Mg2+ binding site [ion binding]; other site 515622004871 G-X-G motif; other site 515622004872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622004873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622004874 active site 515622004875 phosphorylation site [posttranslational modification] 515622004876 intermolecular recognition site; other site 515622004877 dimerization interface [polypeptide binding]; other site 515622004878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622004879 DNA binding site [nucleotide binding] 515622004880 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 515622004881 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 515622004882 hypothetical protein; Reviewed; Region: PRK12497 515622004883 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 515622004884 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 515622004885 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 515622004886 RNA/DNA hybrid binding site [nucleotide binding]; other site 515622004887 active site 515622004888 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 515622004889 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 515622004890 Catalytic site [active] 515622004891 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 515622004892 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 515622004893 GTP/Mg2+ binding site [chemical binding]; other site 515622004894 G4 box; other site 515622004895 G5 box; other site 515622004896 G1 box; other site 515622004897 Switch I region; other site 515622004898 G2 box; other site 515622004899 G3 box; other site 515622004900 Switch II region; other site 515622004901 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 515622004902 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 515622004903 Catalytic site [active] 515622004904 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 515622004905 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 515622004906 active site 515622004907 catalytic motif [active] 515622004908 Zn binding site [ion binding]; other site 515622004909 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622004910 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 515622004911 TM-ABC transporter signature motif; other site 515622004912 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622004913 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 515622004914 TM-ABC transporter signature motif; other site 515622004915 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 515622004916 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515622004917 Walker A/P-loop; other site 515622004918 ATP binding site [chemical binding]; other site 515622004919 Q-loop/lid; other site 515622004920 ABC transporter signature motif; other site 515622004921 Walker B; other site 515622004922 D-loop; other site 515622004923 H-loop/switch region; other site 515622004924 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515622004925 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 515622004926 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622004927 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 515622004928 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 515622004929 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 515622004930 RimM N-terminal domain; Region: RimM; pfam01782 515622004931 PRC-barrel domain; Region: PRC; pfam05239 515622004932 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 515622004933 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 515622004934 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 515622004935 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 515622004936 signal recognition particle protein; Provisional; Region: PRK10867 515622004937 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 515622004938 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 515622004939 GTP binding site [chemical binding]; other site 515622004940 Signal peptide binding domain; Region: SRP_SPB; pfam02978 515622004941 putative DNA-binding protein; Validated; Region: PRK00118 515622004942 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 515622004943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622004944 Helix-turn-helix domain; Region: HTH_18; pfam12833 515622004945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622004946 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 515622004947 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 515622004948 active site 515622004949 Uncharacterized conserved protein [Function unknown]; Region: COG1284 515622004950 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 515622004951 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 515622004952 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 515622004953 threonine dehydratase; Provisional; Region: PRK08198 515622004954 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 515622004955 tetramer interface [polypeptide binding]; other site 515622004956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622004957 catalytic residue [active] 515622004958 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 515622004959 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 515622004960 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 515622004961 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 515622004962 P loop; other site 515622004963 GTP binding site [chemical binding]; other site 515622004964 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 515622004965 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 515622004966 Walker A/P-loop; other site 515622004967 ATP binding site [chemical binding]; other site 515622004968 Q-loop/lid; other site 515622004969 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 515622004970 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 515622004971 ABC transporter signature motif; other site 515622004972 Walker B; other site 515622004973 D-loop; other site 515622004974 H-loop/switch region; other site 515622004975 ribonuclease III; Reviewed; Region: rnc; PRK00102 515622004976 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 515622004977 dimerization interface [polypeptide binding]; other site 515622004978 active site 515622004979 metal binding site [ion binding]; metal-binding site 515622004980 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 515622004981 acyl carrier protein; Provisional; Region: acpP; PRK00982 515622004982 putative phosphate acyltransferase; Provisional; Region: PRK05331 515622004983 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 515622004984 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 515622004985 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 515622004986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622004987 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622004988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622004989 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 515622004990 propionate/acetate kinase; Provisional; Region: PRK12379 515622004991 hypothetical protein; Provisional; Region: PRK13670 515622004992 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 515622004993 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 515622004994 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 515622004995 Metal-binding active site; metal-binding site 515622004996 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 515622004997 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 515622004998 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 515622004999 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 515622005000 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 515622005001 inhibitor binding site; inhibition site 515622005002 active site 515622005003 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 515622005004 active site 515622005005 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 515622005006 active site 515622005007 catalytic triad [active] 515622005008 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622005009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005010 conserved gate region; other site 515622005011 putative PBP binding loops; other site 515622005012 ABC-ATPase subunit interface; other site 515622005013 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622005014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 515622005015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005016 ABC-ATPase subunit interface; other site 515622005017 putative PBP binding loops; other site 515622005018 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622005019 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 515622005020 galactarate dehydratase; Region: galactar-dH20; TIGR03248 515622005021 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 515622005022 Glucuronate isomerase; Region: UxaC; pfam02614 515622005023 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 515622005024 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622005025 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622005026 DNA binding site [nucleotide binding] 515622005027 domain linker motif; other site 515622005028 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622005029 dimerization interface [polypeptide binding]; other site 515622005030 ligand binding site [chemical binding]; other site 515622005031 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 515622005032 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 515622005033 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515622005034 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515622005035 nucleotide binding site [chemical binding]; other site 515622005036 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 515622005037 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 515622005038 Ligand Binding Site [chemical binding]; other site 515622005039 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 515622005040 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 515622005041 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 515622005042 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 515622005043 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 515622005044 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 515622005045 metal binding site [ion binding]; metal-binding site 515622005046 ligand binding site [chemical binding]; other site 515622005047 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 515622005048 ligand binding site [chemical binding]; other site 515622005049 metal binding site [ion binding]; metal-binding site 515622005050 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 515622005051 metal binding site [ion binding]; metal-binding site 515622005052 ligand binding site [chemical binding]; other site 515622005053 Cellulose binding domain; Region: CBM_2; pfam00553 515622005054 Cellulose binding domain; Region: CBM_2; cl17741 515622005055 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622005056 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622005057 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 515622005058 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 515622005059 HlyD family secretion protein; Region: HlyD_3; pfam13437 515622005060 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622005061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005062 dimer interface [polypeptide binding]; other site 515622005063 conserved gate region; other site 515622005064 putative PBP binding loops; other site 515622005065 ABC-ATPase subunit interface; other site 515622005066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005067 dimer interface [polypeptide binding]; other site 515622005068 conserved gate region; other site 515622005069 putative PBP binding loops; other site 515622005070 ABC-ATPase subunit interface; other site 515622005071 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 515622005072 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 515622005073 Walker A/P-loop; other site 515622005074 ATP binding site [chemical binding]; other site 515622005075 Q-loop/lid; other site 515622005076 ABC transporter signature motif; other site 515622005077 Walker B; other site 515622005078 D-loop; other site 515622005079 H-loop/switch region; other site 515622005080 Predicted transcriptional regulators [Transcription]; Region: COG1725 515622005081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 515622005082 DNA-binding site [nucleotide binding]; DNA binding site 515622005083 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 515622005084 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 515622005085 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 515622005086 Cell division protein FtsA; Region: FtsA; smart00842 515622005087 Cell division protein FtsA; Region: FtsA; pfam14450 515622005088 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 515622005089 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 515622005090 CoA-binding site [chemical binding]; other site 515622005091 ATP-binding [chemical binding]; other site 515622005092 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 515622005093 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 515622005094 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 515622005095 active site 515622005096 DNA binding site [nucleotide binding] 515622005097 catalytic site [active] 515622005098 Putative zinc-finger; Region: zf-HC2; pfam13490 515622005099 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 515622005100 MFS/sugar transport protein; Region: MFS_2; pfam13347 515622005101 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 515622005102 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 515622005103 MFS/sugar transport protein; Region: MFS_2; pfam13347 515622005104 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515622005105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622005106 Zn2+ binding site [ion binding]; other site 515622005107 Mg2+ binding site [ion binding]; other site 515622005108 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 515622005109 dimer interface [polypeptide binding]; other site 515622005110 active site 515622005111 ADP-ribose binding site [chemical binding]; other site 515622005112 nudix motif; other site 515622005113 metal binding site [ion binding]; metal-binding site 515622005114 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 515622005115 TrkA-N domain; Region: TrkA_N; pfam02254 515622005116 TrkA-C domain; Region: TrkA_C; pfam02080 515622005117 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 515622005118 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 515622005119 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 515622005120 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622005121 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 515622005122 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 515622005123 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 515622005124 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 515622005125 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515622005126 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622005127 Zn2+ binding site [ion binding]; other site 515622005128 Mg2+ binding site [ion binding]; other site 515622005129 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 515622005130 putative deacylase active site [active] 515622005131 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 515622005132 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 515622005133 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 515622005134 DRTGG domain; Region: DRTGG; pfam07085 515622005135 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 515622005136 DHH family; Region: DHH; pfam01368 515622005137 DHHA2 domain; Region: DHHA2; pfam02833 515622005138 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 515622005139 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 515622005140 Ligand Binding Site [chemical binding]; other site 515622005141 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622005142 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622005143 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 515622005144 Walker A/P-loop; other site 515622005145 ATP binding site [chemical binding]; other site 515622005146 Q-loop/lid; other site 515622005147 ABC transporter signature motif; other site 515622005148 Walker B; other site 515622005149 D-loop; other site 515622005150 H-loop/switch region; other site 515622005151 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622005152 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622005153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622005154 Walker A/P-loop; other site 515622005155 ATP binding site [chemical binding]; other site 515622005156 Q-loop/lid; other site 515622005157 ABC transporter signature motif; other site 515622005158 Walker B; other site 515622005159 D-loop; other site 515622005160 H-loop/switch region; other site 515622005161 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 515622005162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622005163 S-adenosylmethionine binding site [chemical binding]; other site 515622005164 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 515622005165 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 515622005166 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515622005167 putative DNA binding site [nucleotide binding]; other site 515622005168 putative Zn2+ binding site [ion binding]; other site 515622005169 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 515622005170 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 515622005171 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 515622005172 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622005173 phosphodiesterase; Provisional; Region: PRK12704 515622005174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622005175 Zn2+ binding site [ion binding]; other site 515622005176 Mg2+ binding site [ion binding]; other site 515622005177 recombination regulator RecX; Reviewed; Region: recX; PRK00117 515622005178 recombinase A; Provisional; Region: recA; PRK09354 515622005179 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 515622005180 hexamer interface [polypeptide binding]; other site 515622005181 Walker A motif; other site 515622005182 ATP binding site [chemical binding]; other site 515622005183 Walker B motif; other site 515622005184 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 515622005185 HSP70 interaction site [polypeptide binding]; other site 515622005186 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579 515622005187 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 515622005188 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 515622005189 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 515622005190 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 515622005191 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 515622005192 Peptidase family U32; Region: Peptidase_U32; pfam01136 515622005193 Collagenase; Region: DUF3656; pfam12392 515622005194 Cell division protein ZapA; Region: ZapA; pfam05164 515622005195 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 515622005196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622005197 Walker A motif; other site 515622005198 ATP binding site [chemical binding]; other site 515622005199 Walker B motif; other site 515622005200 arginine finger; other site 515622005201 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 515622005202 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 515622005203 RuvA N terminal domain; Region: RuvA_N; pfam01330 515622005204 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 515622005205 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 515622005206 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 515622005207 homodimer interface [polypeptide binding]; other site 515622005208 substrate-cofactor binding pocket; other site 515622005209 catalytic residue [active] 515622005210 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 515622005211 Domain of unknown function DUF20; Region: UPF0118; pfam01594 515622005212 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 515622005213 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 515622005214 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 515622005215 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 515622005216 Ligand binding site; other site 515622005217 Putative Catalytic site; other site 515622005218 DXD motif; other site 515622005219 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 515622005220 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 515622005221 substrate binding site [chemical binding]; other site 515622005222 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 515622005223 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 515622005224 substrate binding site [chemical binding]; other site 515622005225 ligand binding site [chemical binding]; other site 515622005226 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 515622005227 ketol-acid reductoisomerase; Provisional; Region: PRK05479 515622005228 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 515622005229 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 515622005230 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 515622005231 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 515622005232 putative valine binding site [chemical binding]; other site 515622005233 dimer interface [polypeptide binding]; other site 515622005234 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 515622005235 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 515622005236 active site 515622005237 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622005238 Ligand Binding Site [chemical binding]; other site 515622005239 Molecular Tunnel; other site 515622005240 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 515622005241 DNA topoisomerase III; Provisional; Region: PRK07726 515622005242 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 515622005243 active site 515622005244 putative interdomain interaction site [polypeptide binding]; other site 515622005245 putative metal-binding site [ion binding]; other site 515622005246 putative nucleotide binding site [chemical binding]; other site 515622005247 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 515622005248 domain I; other site 515622005249 DNA binding groove [nucleotide binding] 515622005250 phosphate binding site [ion binding]; other site 515622005251 domain II; other site 515622005252 domain III; other site 515622005253 nucleotide binding site [chemical binding]; other site 515622005254 catalytic site [active] 515622005255 domain IV; other site 515622005256 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 515622005257 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 515622005258 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 515622005259 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 515622005260 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 515622005261 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 515622005262 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 515622005263 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 515622005264 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 515622005265 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 515622005266 argininosuccinate lyase; Provisional; Region: PRK00855 515622005267 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 515622005268 active sites [active] 515622005269 tetramer interface [polypeptide binding]; other site 515622005270 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 515622005271 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622005272 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 515622005273 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622005274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005275 dimer interface [polypeptide binding]; other site 515622005276 conserved gate region; other site 515622005277 putative PBP binding loops; other site 515622005278 ABC-ATPase subunit interface; other site 515622005279 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622005280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005281 dimer interface [polypeptide binding]; other site 515622005282 conserved gate region; other site 515622005283 putative PBP binding loops; other site 515622005284 ABC-ATPase subunit interface; other site 515622005285 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 515622005286 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 515622005287 Walker A/P-loop; other site 515622005288 ATP binding site [chemical binding]; other site 515622005289 Q-loop/lid; other site 515622005290 ABC transporter signature motif; other site 515622005291 Walker B; other site 515622005292 D-loop; other site 515622005293 H-loop/switch region; other site 515622005294 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 515622005295 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 515622005296 putative active site [active] 515622005297 PhoH-like protein; Region: PhoH; pfam02562 515622005298 putative transporter; Provisional; Region: PRK11660 515622005299 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 515622005300 Sulfate transporter family; Region: Sulfate_transp; pfam00916 515622005301 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 515622005302 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 515622005303 active site 515622005304 metal-binding site [ion binding] 515622005305 nucleotide-binding site [chemical binding]; other site 515622005306 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 515622005307 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 515622005308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622005309 metal binding site [ion binding]; metal-binding site 515622005310 active site 515622005311 I-site; other site 515622005312 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622005313 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 515622005314 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 515622005315 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 515622005316 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515622005317 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515622005318 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 515622005319 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515622005320 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515622005321 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 515622005322 IMP binding site; other site 515622005323 dimer interface [polypeptide binding]; other site 515622005324 interdomain contacts; other site 515622005325 partial ornithine binding site; other site 515622005326 FIST N domain; Region: FIST; cl10701 515622005327 FIST C domain; Region: FIST_C; pfam10442 515622005328 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622005329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622005330 metal binding site [ion binding]; metal-binding site 515622005331 active site 515622005332 I-site; other site 515622005333 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 515622005334 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 515622005335 Low molecular weight phosphatase family; Region: LMWPc; cd00115 515622005336 active site 515622005337 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 515622005338 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622005339 dimer interface [polypeptide binding]; other site 515622005340 putative CheW interface [polypeptide binding]; other site 515622005341 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 515622005342 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 515622005343 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 515622005344 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 515622005345 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515622005346 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515622005347 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515622005348 MFS/sugar transport protein; Region: MFS_2; pfam13347 515622005349 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 515622005350 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622005351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622005352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622005353 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622005354 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 515622005355 active site 515622005356 ATP binding site [chemical binding]; other site 515622005357 substrate binding site [chemical binding]; other site 515622005358 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622005359 Zn2+ binding site [ion binding]; other site 515622005360 Mg2+ binding site [ion binding]; other site 515622005361 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 515622005362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622005363 Coenzyme A binding pocket [chemical binding]; other site 515622005364 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 515622005365 hypothetical protein; Provisional; Region: PHA03169 515622005366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 515622005367 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 515622005368 Uncharacterized conserved protein [Function unknown]; Region: COG1434 515622005369 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 515622005370 putative active site [active] 515622005371 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 515622005372 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515622005373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622005374 TPR motif; other site 515622005375 Tetratricopeptide repeat; Region: TPR_16; pfam13432 515622005376 binding surface 515622005377 TPR repeat; Region: TPR_11; pfam13414 515622005378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622005379 binding surface 515622005380 TPR motif; other site 515622005381 Tetratricopeptide repeat; Region: TPR_12; pfam13424 515622005382 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 515622005383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622005384 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622005385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622005386 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 515622005387 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 515622005388 putative substrate binding site [chemical binding]; other site 515622005389 putative ATP binding site [chemical binding]; other site 515622005390 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 515622005391 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 515622005392 substrate binding [chemical binding]; other site 515622005393 active site 515622005394 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 515622005395 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 515622005396 active site 515622005397 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622005398 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622005399 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622005400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005401 dimer interface [polypeptide binding]; other site 515622005402 conserved gate region; other site 515622005403 putative PBP binding loops; other site 515622005404 ABC-ATPase subunit interface; other site 515622005405 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622005406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005407 dimer interface [polypeptide binding]; other site 515622005408 conserved gate region; other site 515622005409 ABC-ATPase subunit interface; other site 515622005410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622005411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622005412 DNA binding site [nucleotide binding] 515622005413 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622005414 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 515622005415 active site 515622005416 catalytic site [active] 515622005417 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 515622005418 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 515622005419 Cellulose binding domain; Region: CBM_2; pfam00553 515622005420 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 515622005421 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 515622005422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 515622005423 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622005424 active site 515622005425 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 515622005426 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 515622005427 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 515622005428 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 515622005429 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 515622005430 putative L-serine binding site [chemical binding]; other site 515622005431 Response regulator receiver domain; Region: Response_reg; pfam00072 515622005432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622005433 active site 515622005434 phosphorylation site [posttranslational modification] 515622005435 intermolecular recognition site; other site 515622005436 dimerization interface [polypeptide binding]; other site 515622005437 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622005438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622005439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622005440 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 515622005441 HAMP domain; Region: HAMP; pfam00672 515622005442 Histidine kinase; Region: His_kinase; pfam06580 515622005443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622005444 ATP binding site [chemical binding]; other site 515622005445 Mg2+ binding site [ion binding]; other site 515622005446 G-X-G motif; other site 515622005447 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622005448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005449 dimer interface [polypeptide binding]; other site 515622005450 conserved gate region; other site 515622005451 putative PBP binding loops; other site 515622005452 ABC-ATPase subunit interface; other site 515622005453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005454 dimer interface [polypeptide binding]; other site 515622005455 conserved gate region; other site 515622005456 putative PBP binding loops; other site 515622005457 ABC-ATPase subunit interface; other site 515622005458 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622005459 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622005460 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 515622005461 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 515622005462 transcription termination factor Rho; Provisional; Region: rho; PRK09376 515622005463 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 515622005464 RNA binding site [nucleotide binding]; other site 515622005465 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622005466 Walker A motif; other site 515622005467 ATP binding site [chemical binding]; other site 515622005468 Walker B motif; other site 515622005469 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 515622005470 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 515622005471 active site 515622005472 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 515622005473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622005474 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 515622005475 active site 515622005476 motif I; other site 515622005477 motif II; other site 515622005478 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 515622005479 Maf-like protein; Region: Maf; pfam02545 515622005480 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 515622005481 active site 515622005482 dimer interface [polypeptide binding]; other site 515622005483 polyphosphate kinase; Provisional; Region: PRK05443 515622005484 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 515622005485 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 515622005486 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 515622005487 putative domain interface [polypeptide binding]; other site 515622005488 putative active site [active] 515622005489 catalytic site [active] 515622005490 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 515622005491 putative domain interface [polypeptide binding]; other site 515622005492 putative active site [active] 515622005493 catalytic site [active] 515622005494 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 515622005495 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 515622005496 Chorismate mutase type II; Region: CM_2; smart00830 515622005497 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 515622005498 Prephenate dehydratase; Region: PDT; pfam00800 515622005499 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 515622005500 putative L-Phe binding site [chemical binding]; other site 515622005501 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 515622005502 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 515622005503 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 515622005504 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 515622005505 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 515622005506 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 515622005507 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 515622005508 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 515622005509 active site 515622005510 catalytic site [active] 515622005511 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 515622005512 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 515622005513 active site 515622005514 DNA binding site [nucleotide binding] 515622005515 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 515622005516 active site 515622005517 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 515622005518 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 515622005519 active site 515622005520 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 515622005521 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622005522 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 515622005523 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 515622005524 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 515622005525 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 515622005526 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 515622005527 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 515622005528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515622005529 Predicted dehydrogenase [General function prediction only]; Region: COG0579 515622005530 hydroxyglutarate oxidase; Provisional; Region: PRK11728 515622005531 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 515622005532 glycerol kinase; Provisional; Region: glpK; PRK00047 515622005533 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 515622005534 N- and C-terminal domain interface [polypeptide binding]; other site 515622005535 active site 515622005536 MgATP binding site [chemical binding]; other site 515622005537 catalytic site [active] 515622005538 metal binding site [ion binding]; metal-binding site 515622005539 glycerol binding site [chemical binding]; other site 515622005540 homotetramer interface [polypeptide binding]; other site 515622005541 homodimer interface [polypeptide binding]; other site 515622005542 FBP binding site [chemical binding]; other site 515622005543 protein IIAGlc interface [polypeptide binding]; other site 515622005544 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 515622005545 Carboxylesterase family; Region: COesterase; pfam00135 515622005546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 515622005547 substrate binding pocket [chemical binding]; other site 515622005548 catalytic triad [active] 515622005549 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 515622005550 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 515622005551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622005552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622005553 metal binding site [ion binding]; metal-binding site 515622005554 active site 515622005555 I-site; other site 515622005556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 515622005557 PAS fold; Region: PAS_3; pfam08447 515622005558 putative active site [active] 515622005559 heme pocket [chemical binding]; other site 515622005560 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622005561 metal binding site [ion binding]; metal-binding site 515622005562 active site 515622005563 I-site; other site 515622005564 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622005565 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 515622005566 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 515622005567 catalytic residue [active] 515622005568 PilZ domain; Region: PilZ; pfam07238 515622005569 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 515622005570 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 515622005571 phosphate binding site [ion binding]; other site 515622005572 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 515622005573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 515622005574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515622005575 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; cl11685 515622005576 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515622005577 nucleotide binding site [chemical binding]; other site 515622005578 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 515622005579 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 515622005580 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 515622005581 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 515622005582 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 515622005583 P-loop; other site 515622005584 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515622005585 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 515622005586 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 515622005587 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 515622005588 Predicted membrane protein [Function unknown]; Region: COG1971 515622005589 Domain of unknown function DUF; Region: DUF204; pfam02659 515622005590 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 515622005591 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 515622005592 Predicted RNA-binding protein; Region: RNA_bind_2; cl00662 515622005593 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 515622005594 N- and C-terminal domain interface [polypeptide binding]; other site 515622005595 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 515622005596 active site 515622005597 putative catalytic site [active] 515622005598 metal binding site [ion binding]; metal-binding site 515622005599 ATP binding site [chemical binding]; other site 515622005600 carbohydrate binding site [chemical binding]; other site 515622005601 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 515622005602 intersubunit interface [polypeptide binding]; other site 515622005603 active site 515622005604 Zn2+ binding site [ion binding]; other site 515622005605 L-rhamnose isomerase; Provisional; Region: PRK01076 515622005606 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 515622005607 CAAX protease self-immunity; Region: Abi; pfam02517 515622005608 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 515622005609 active site 515622005610 catalytic residues [active] 515622005611 Cupin domain; Region: Cupin_2; pfam07883 515622005612 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 515622005613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622005614 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 515622005615 active site 515622005616 Uncharacterized conserved protein [Function unknown]; Region: COG1284 515622005617 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 515622005618 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 515622005619 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 515622005620 putative metal binding residues [ion binding]; other site 515622005621 signature motif; other site 515622005622 dimer interface [polypeptide binding]; other site 515622005623 active site 515622005624 polyP binding site; other site 515622005625 substrate binding site [chemical binding]; other site 515622005626 acceptor-phosphate pocket; other site 515622005627 CotH protein; Region: CotH; pfam08757 515622005628 Predicted membrane protein [Function unknown]; Region: COG4267 515622005629 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 515622005630 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622005631 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 515622005632 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 515622005633 NodB motif; other site 515622005634 putative active site [active] 515622005635 putative catalytic site [active] 515622005636 putative Zn binding site [ion binding]; other site 515622005637 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 515622005638 GAF domain; Region: GAF_3; pfam13492 515622005639 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515622005640 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 515622005641 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 515622005642 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 515622005643 dimer interface [polypeptide binding]; other site 515622005644 active site 515622005645 glycine-pyridoxal phosphate binding site [chemical binding]; other site 515622005646 folate binding site [chemical binding]; other site 515622005647 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 515622005648 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 515622005649 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 515622005650 active site 515622005651 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622005652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622005653 active site 515622005654 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 515622005655 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 515622005656 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 515622005657 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 515622005658 Competence protein; Region: Competence; pfam03772 515622005659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515622005660 Sporulation and spore germination; Region: Germane; pfam10646 515622005661 Sporulation and spore germination; Region: Germane; pfam10646 515622005662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622005663 HAMP domain; Region: HAMP; pfam00672 515622005664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622005665 dimer interface [polypeptide binding]; other site 515622005666 phosphorylation site [posttranslational modification] 515622005667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622005668 ATP binding site [chemical binding]; other site 515622005669 Mg2+ binding site [ion binding]; other site 515622005670 G-X-G motif; other site 515622005671 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622005672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622005673 active site 515622005674 phosphorylation site [posttranslational modification] 515622005675 intermolecular recognition site; other site 515622005676 dimerization interface [polypeptide binding]; other site 515622005677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622005678 DNA binding site [nucleotide binding] 515622005679 SLBB domain; Region: SLBB; pfam10531 515622005680 comEA protein; Region: comE; TIGR01259 515622005681 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622005682 acetylornithine aminotransferase; Provisional; Region: PRK02627 515622005683 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 515622005684 inhibitor-cofactor binding pocket; inhibition site 515622005685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622005686 catalytic residue [active] 515622005687 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 515622005688 feedback inhibition sensing region; other site 515622005689 homohexameric interface [polypeptide binding]; other site 515622005690 nucleotide binding site [chemical binding]; other site 515622005691 N-acetyl-L-glutamate binding site [chemical binding]; other site 515622005692 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 515622005693 heterotetramer interface [polypeptide binding]; other site 515622005694 active site pocket [active] 515622005695 cleavage site 515622005696 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 515622005697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622005698 Coenzyme A binding pocket [chemical binding]; other site 515622005699 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 515622005700 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 515622005701 argininosuccinate synthase; Provisional; Region: PRK13820 515622005702 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 515622005703 ANP binding site [chemical binding]; other site 515622005704 Substrate Binding Site II [chemical binding]; other site 515622005705 Substrate Binding Site I [chemical binding]; other site 515622005706 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 515622005707 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 515622005708 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622005709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622005710 DNA binding site [nucleotide binding] 515622005711 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622005712 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 515622005713 putative binding surface; other site 515622005714 active site 515622005715 peptide chain release factor 1; Validated; Region: prfA; PRK00591 515622005716 This domain is found in peptide chain release factors; Region: PCRF; smart00937 515622005717 RF-1 domain; Region: RF-1; pfam00472 515622005718 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 515622005719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622005720 S-adenosylmethionine binding site [chemical binding]; other site 515622005721 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 515622005722 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 515622005723 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 515622005724 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 515622005725 Walker A/P-loop; other site 515622005726 ATP binding site [chemical binding]; other site 515622005727 Q-loop/lid; other site 515622005728 ABC transporter signature motif; other site 515622005729 Walker B; other site 515622005730 D-loop; other site 515622005731 H-loop/switch region; other site 515622005732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005733 dimer interface [polypeptide binding]; other site 515622005734 conserved gate region; other site 515622005735 putative PBP binding loops; other site 515622005736 ABC-ATPase subunit interface; other site 515622005737 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 515622005738 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515622005739 substrate binding pocket [chemical binding]; other site 515622005740 membrane-bound complex binding site; other site 515622005741 hinge residues; other site 515622005742 RNA polymerase factor sigma-70; Validated; Region: PRK08295 515622005743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515622005744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 515622005745 DNA binding residues [nucleotide binding] 515622005746 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 515622005747 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 515622005748 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 515622005749 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 515622005750 active site 515622005751 metal binding site [ion binding]; metal-binding site 515622005752 dimerization interface [polypeptide binding]; other site 515622005753 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622005754 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 515622005755 active site 515622005756 HIGH motif; other site 515622005757 nucleotide binding site [chemical binding]; other site 515622005758 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 515622005759 KMSKS motif; other site 515622005760 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 515622005761 tRNA binding surface [nucleotide binding]; other site 515622005762 anticodon binding site; other site 515622005763 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 515622005764 homotrimer interaction site [polypeptide binding]; other site 515622005765 zinc binding site [ion binding]; other site 515622005766 CDP-binding sites; other site 515622005767 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 515622005768 AzlC protein; Region: AzlC; pfam03591 515622005769 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 515622005770 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 515622005771 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 515622005772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622005773 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622005774 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622005775 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 515622005776 trehalose synthase; Region: treS_nterm; TIGR02456 515622005777 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 515622005778 active site 515622005779 catalytic site [active] 515622005780 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 515622005781 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 515622005782 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 515622005783 active site 515622005784 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 515622005785 active site 515622005786 catalytic triad [active] 515622005787 oxyanion hole [active] 515622005788 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 515622005789 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 515622005790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 515622005791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622005792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622005793 dimer interface [polypeptide binding]; other site 515622005794 phosphorylation site [posttranslational modification] 515622005795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622005796 ATP binding site [chemical binding]; other site 515622005797 Mg2+ binding site [ion binding]; other site 515622005798 G-X-G motif; other site 515622005799 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622005800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622005801 active site 515622005802 phosphorylation site [posttranslational modification] 515622005803 intermolecular recognition site; other site 515622005804 dimerization interface [polypeptide binding]; other site 515622005805 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622005806 DNA binding site [nucleotide binding] 515622005807 Protein of unknown function (DUF975); Region: DUF975; cl10504 515622005808 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 515622005809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 515622005810 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622005811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622005812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622005813 metal binding site [ion binding]; metal-binding site 515622005814 active site 515622005815 I-site; other site 515622005816 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622005817 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622005818 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 515622005819 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 515622005820 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 515622005821 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622005822 active site 515622005823 HIGH motif; other site 515622005824 nucleotide binding site [chemical binding]; other site 515622005825 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 515622005826 KMSK motif region; other site 515622005827 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 515622005828 tRNA binding surface [nucleotide binding]; other site 515622005829 anticodon binding site; other site 515622005830 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 515622005831 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 515622005832 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 515622005833 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 515622005834 shikimate binding site; other site 515622005835 NAD(P) binding site [chemical binding]; other site 515622005836 shikimate kinase; Reviewed; Region: aroK; PRK00131 515622005837 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 515622005838 ADP binding site [chemical binding]; other site 515622005839 magnesium binding site [ion binding]; other site 515622005840 putative shikimate binding site; other site 515622005841 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515622005842 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 515622005843 Walker A/P-loop; other site 515622005844 ATP binding site [chemical binding]; other site 515622005845 Q-loop/lid; other site 515622005846 ABC transporter signature motif; other site 515622005847 Walker B; other site 515622005848 D-loop; other site 515622005849 H-loop/switch region; other site 515622005850 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515622005851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515622005852 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 515622005853 Walker A/P-loop; other site 515622005854 ATP binding site [chemical binding]; other site 515622005855 Q-loop/lid; other site 515622005856 ABC transporter signature motif; other site 515622005857 Walker B; other site 515622005858 D-loop; other site 515622005859 H-loop/switch region; other site 515622005860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515622005861 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515622005862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005863 dimer interface [polypeptide binding]; other site 515622005864 conserved gate region; other site 515622005865 putative PBP binding loops; other site 515622005866 ABC-ATPase subunit interface; other site 515622005867 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515622005868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622005869 dimer interface [polypeptide binding]; other site 515622005870 conserved gate region; other site 515622005871 putative PBP binding loops; other site 515622005872 ABC-ATPase subunit interface; other site 515622005873 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515622005874 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 515622005875 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 515622005876 ATP cone domain; Region: ATP-cone; pfam03477 515622005877 cell division protein FtsZ; Validated; Region: PRK09330 515622005878 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 515622005879 nucleotide binding site [chemical binding]; other site 515622005880 SulA interaction site; other site 515622005881 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 515622005882 cell division protein FtsW; Region: ftsW; TIGR02614 515622005883 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 515622005884 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515622005885 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515622005886 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 515622005887 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 515622005888 Mg++ binding site [ion binding]; other site 515622005889 putative catalytic motif [active] 515622005890 putative substrate binding site [chemical binding]; other site 515622005891 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 515622005892 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 515622005893 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 515622005894 Septum formation initiator; Region: DivIC; cl17659 515622005895 MraW methylase family; Region: Methyltransf_5; pfam01795 515622005896 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 515622005897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 515622005898 MraZ protein; Region: MraZ; pfam02381 515622005899 MraZ protein; Region: MraZ; pfam02381 515622005900 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 515622005901 GTP-binding protein YchF; Reviewed; Region: PRK09601 515622005902 YchF GTPase; Region: YchF; cd01900 515622005903 G1 box; other site 515622005904 GTP/Mg2+ binding site [chemical binding]; other site 515622005905 Switch I region; other site 515622005906 G2 box; other site 515622005907 Switch II region; other site 515622005908 G3 box; other site 515622005909 G4 box; other site 515622005910 G5 box; other site 515622005911 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 515622005912 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 515622005913 ADP-ribose binding site [chemical binding]; other site 515622005914 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 515622005915 PAS fold; Region: PAS_3; pfam08447 515622005916 PAS fold; Region: PAS_4; pfam08448 515622005917 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622005918 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622005919 metal binding site [ion binding]; metal-binding site 515622005920 active site 515622005921 I-site; other site 515622005922 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 515622005923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515622005924 substrate binding pocket [chemical binding]; other site 515622005925 membrane-bound complex binding site; other site 515622005926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622005927 metal binding site [ion binding]; metal-binding site 515622005928 active site 515622005929 I-site; other site 515622005930 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622005931 HD domain; Region: HD_3; pfam13023 515622005932 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 515622005933 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 515622005934 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 515622005935 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 515622005936 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515622005937 putative DNA binding site [nucleotide binding]; other site 515622005938 putative Zn2+ binding site [ion binding]; other site 515622005939 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 515622005940 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 515622005941 Rhomboid family; Region: Rhomboid; cl11446 515622005942 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 515622005943 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 515622005944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 515622005945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 515622005946 MORN repeat; Region: MORN; cl14787 515622005947 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 515622005948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622005949 FeS/SAM binding site; other site 515622005950 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 515622005951 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 515622005952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622005953 FeS/SAM binding site; other site 515622005954 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 515622005955 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 515622005956 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 515622005957 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 515622005958 active site 515622005959 metal binding site [ion binding]; metal-binding site 515622005960 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 515622005961 Part of AAA domain; Region: AAA_19; pfam13245 515622005962 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 515622005963 Family description; Region: UvrD_C_2; pfam13538 515622005964 AAA domain; Region: AAA_21; pfam13304 515622005965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622005966 Walker B; other site 515622005967 D-loop; other site 515622005968 H-loop/switch region; other site 515622005969 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 515622005970 putative active site [active] 515622005971 putative metal-binding site [ion binding]; other site 515622005972 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 515622005973 additional DNA contacts [nucleotide binding]; other site 515622005974 mismatch recognition site; other site 515622005975 active site 515622005976 zinc binding site [ion binding]; other site 515622005977 DNA intercalation site [nucleotide binding]; other site 515622005978 Uncharacterized conserved protein [Function unknown]; Region: COG1700 515622005979 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 515622005980 Protein of unknown function (DUF524); Region: DUF524; pfam04411 515622005981 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 515622005982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 515622005983 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 515622005984 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 515622005985 DNA binding site [nucleotide binding] 515622005986 substrate interaction site [chemical binding]; other site 515622005987 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 515622005988 Helix-turn-helix domain; Region: HTH_17; pfam12728 515622005989 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 515622005990 Integrase core domain; Region: rve; pfam00665 515622005991 FRG domain; Region: FRG; cl07460 515622005992 SpoVG; Region: SpoVG; cl00915 515622005993 flavodoxin; Provisional; Region: PRK06242 515622005994 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 515622005995 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 515622005996 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 515622005997 dimer interface [polypeptide binding]; other site 515622005998 catalytic triad [active] 515622005999 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 515622006000 BRO family, N-terminal domain; Region: Bro-N; pfam02498 515622006001 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622006002 Coenzyme A binding pocket [chemical binding]; other site 515622006003 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 515622006004 nucleoside/Zn binding site; other site 515622006005 dimer interface [polypeptide binding]; other site 515622006006 catalytic motif [active] 515622006007 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 515622006008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622006009 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622006010 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 515622006011 active site 515622006012 Ap4A binding cleft/pocket [chemical binding]; other site 515622006013 P4 phosphate binding site; other site 515622006014 nudix motif; other site 515622006015 putative P2/P3 phosphate binding site [ion binding]; other site 515622006016 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 515622006017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622006018 Coenzyme A binding pocket [chemical binding]; other site 515622006019 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 515622006020 catalytic core [active] 515622006021 topology modulation protein; Reviewed; Region: PRK08118 515622006022 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 515622006023 active site 515622006024 AAA domain; Region: AAA_21; pfam13304 515622006025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622006026 Zn2+ binding site [ion binding]; other site 515622006027 Mg2+ binding site [ion binding]; other site 515622006028 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 515622006029 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 515622006030 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622006031 CAAX protease self-immunity; Region: Abi; pfam02517 515622006032 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 515622006033 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 515622006034 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 515622006035 nudix motif; other site 515622006036 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 515622006037 putative deacylase active site [active] 515622006038 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 515622006039 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 515622006040 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 515622006041 Protein of unknown function (DUF328); Region: DUF328; pfam03883 515622006042 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 515622006043 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 515622006044 catalytic triad [active] 515622006045 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622006046 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622006047 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622006048 metal binding site [ion binding]; metal-binding site 515622006049 active site 515622006050 I-site; other site 515622006051 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 515622006052 Protein of unknown function (DUF328); Region: DUF328; cl01143 515622006053 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 515622006054 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 515622006055 catalytic triad [active] 515622006056 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 515622006057 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 515622006058 active site 515622006059 8-oxo-dGMP binding site [chemical binding]; other site 515622006060 nudix motif; other site 515622006061 metal binding site [ion binding]; metal-binding site 515622006062 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 515622006063 ArsC family; Region: ArsC; pfam03960 515622006064 catalytic residue [active] 515622006065 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 515622006066 putative FMN binding site [chemical binding]; other site 515622006067 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 515622006068 active site 515622006069 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622006070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622006071 DNA binding site [nucleotide binding] 515622006072 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622006073 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622006074 active site 515622006075 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622006076 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 515622006077 TM-ABC transporter signature motif; other site 515622006078 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622006079 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 515622006080 TM-ABC transporter signature motif; other site 515622006081 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 515622006082 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515622006083 Walker A/P-loop; other site 515622006084 ATP binding site [chemical binding]; other site 515622006085 Q-loop/lid; other site 515622006086 ABC transporter signature motif; other site 515622006087 Walker B; other site 515622006088 D-loop; other site 515622006089 H-loop/switch region; other site 515622006090 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515622006091 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 515622006092 putative ligand binding site [chemical binding]; other site 515622006093 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 515622006094 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622006095 Cache domain; Region: Cache_1; pfam02743 515622006096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622006097 dimerization interface [polypeptide binding]; other site 515622006098 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622006099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622006100 metal binding site [ion binding]; metal-binding site 515622006101 active site 515622006102 I-site; other site 515622006103 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 515622006104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622006105 active site 515622006106 phosphorylation site [posttranslational modification] 515622006107 intermolecular recognition site; other site 515622006108 dimerization interface [polypeptide binding]; other site 515622006109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622006110 Zn2+ binding site [ion binding]; other site 515622006111 Mg2+ binding site [ion binding]; other site 515622006112 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622006113 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622006114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622006115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622006116 dimer interface [polypeptide binding]; other site 515622006117 phosphorylation site [posttranslational modification] 515622006118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622006119 ATP binding site [chemical binding]; other site 515622006120 Mg2+ binding site [ion binding]; other site 515622006121 G-X-G motif; other site 515622006122 Response regulator receiver domain; Region: Response_reg; pfam00072 515622006123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622006124 active site 515622006125 phosphorylation site [posttranslational modification] 515622006126 intermolecular recognition site; other site 515622006127 dimerization interface [polypeptide binding]; other site 515622006128 Hpt domain; Region: Hpt; pfam01627 515622006129 putative binding surface; other site 515622006130 active site 515622006131 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 515622006132 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622006133 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622006134 metal binding site [ion binding]; metal-binding site 515622006135 active site 515622006136 I-site; other site 515622006137 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 515622006138 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622006139 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622006140 dimer interface [polypeptide binding]; other site 515622006141 putative CheW interface [polypeptide binding]; other site 515622006142 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 515622006143 Na2 binding site [ion binding]; other site 515622006144 putative substrate binding site 1 [chemical binding]; other site 515622006145 Na binding site 1 [ion binding]; other site 515622006146 putative substrate binding site 2 [chemical binding]; other site 515622006147 hypothetical protein; Provisional; Region: PRK03881 515622006148 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 515622006149 AMMECR1; Region: AMMECR1; pfam01871 515622006150 WYL domain; Region: WYL; pfam13280 515622006151 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 515622006152 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 515622006153 active site 515622006154 catalytic site [active] 515622006155 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622006156 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622006157 dimer interface [polypeptide binding]; other site 515622006158 putative CheW interface [polypeptide binding]; other site 515622006159 Uncharacterized conserved protein [Function unknown]; Region: COG3287 515622006160 FIST N domain; Region: FIST; cl10701 515622006161 FIST C domain; Region: FIST_C; pfam10442 515622006162 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 515622006163 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 515622006164 phosphate binding site [ion binding]; other site 515622006165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 515622006166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 515622006167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515622006168 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 515622006169 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 515622006170 active site 515622006171 nucleophile elbow; other site 515622006172 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622006173 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 515622006174 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 515622006175 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 515622006176 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515622006177 catalytic residue [active] 515622006178 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 515622006179 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 515622006180 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 515622006181 Ligand Binding Site [chemical binding]; other site 515622006182 Response regulator receiver domain; Region: Response_reg; pfam00072 515622006183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622006184 active site 515622006185 phosphorylation site [posttranslational modification] 515622006186 intermolecular recognition site; other site 515622006187 dimerization interface [polypeptide binding]; other site 515622006188 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 515622006189 catalytic core [active] 515622006190 GTPase RsgA; Reviewed; Region: PRK00098 515622006191 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 515622006192 RNA binding site [nucleotide binding]; other site 515622006193 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 515622006194 GTPase/Zn-binding domain interface [polypeptide binding]; other site 515622006195 GTP/Mg2+ binding site [chemical binding]; other site 515622006196 G4 box; other site 515622006197 G5 box; other site 515622006198 G1 box; other site 515622006199 Switch I region; other site 515622006200 G2 box; other site 515622006201 G3 box; other site 515622006202 Switch II region; other site 515622006203 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 515622006204 Catalytic domain of Protein Kinases; Region: PKc; cd00180 515622006205 active site 515622006206 ATP binding site [chemical binding]; other site 515622006207 substrate binding site [chemical binding]; other site 515622006208 activation loop (A-loop); other site 515622006209 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 515622006210 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 515622006211 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 515622006212 active site 515622006213 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 515622006214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622006215 FeS/SAM binding site; other site 515622006216 16S rRNA methyltransferase B; Provisional; Region: PRK14902 515622006217 NusB family; Region: NusB; pfam01029 515622006218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622006219 S-adenosylmethionine binding site [chemical binding]; other site 515622006220 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 515622006221 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 515622006222 putative active site [active] 515622006223 substrate binding site [chemical binding]; other site 515622006224 putative cosubstrate binding site; other site 515622006225 catalytic site [active] 515622006226 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 515622006227 substrate binding site [chemical binding]; other site 515622006228 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 515622006229 active site 515622006230 catalytic residues [active] 515622006231 metal binding site [ion binding]; metal-binding site 515622006232 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 515622006233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515622006234 ATP binding site [chemical binding]; other site 515622006235 putative Mg++ binding site [ion binding]; other site 515622006236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515622006237 ATP-binding site [chemical binding]; other site 515622006238 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 515622006239 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 515622006240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515622006241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515622006242 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 515622006243 DHH family; Region: DHH; pfam01368 515622006244 DHHA1 domain; Region: DHHA1; pfam02272 515622006245 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 515622006246 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 515622006247 Protein export membrane protein; Region: SecD_SecF; pfam02355 515622006248 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 515622006249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622006250 FeS/SAM binding site; other site 515622006251 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 515622006252 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 515622006253 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 515622006254 Domain of unknown function DUF21; Region: DUF21; pfam01595 515622006255 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 515622006256 Transporter associated domain; Region: CorC_HlyC; smart01091 515622006257 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 515622006258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622006259 motif II; other site 515622006260 Domain of unknown function (DUF718); Region: DUF718; cl01281 515622006261 histidyl-tRNA synthetase; Region: hisS; TIGR00442 515622006262 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 515622006263 dimer interface [polypeptide binding]; other site 515622006264 motif 1; other site 515622006265 active site 515622006266 motif 2; other site 515622006267 motif 3; other site 515622006268 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622006269 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 515622006270 nucleotidyl binding site; other site 515622006271 metal binding site [ion binding]; metal-binding site 515622006272 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622006273 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 515622006274 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622006275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622006276 DNA binding site [nucleotide binding] 515622006277 domain linker motif; other site 515622006278 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622006279 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622006280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622006281 dimer interface [polypeptide binding]; other site 515622006282 conserved gate region; other site 515622006283 putative PBP binding loops; other site 515622006284 ABC-ATPase subunit interface; other site 515622006285 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515622006286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622006287 dimer interface [polypeptide binding]; other site 515622006288 conserved gate region; other site 515622006289 putative PBP binding loops; other site 515622006290 ABC-ATPase subunit interface; other site 515622006291 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515622006292 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 515622006293 DNA protecting protein DprA; Region: dprA; TIGR00732 515622006294 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 515622006295 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 515622006296 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 515622006297 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 515622006298 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 515622006299 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622006300 Walker A motif; other site 515622006301 ATP binding site [chemical binding]; other site 515622006302 Walker B motif; other site 515622006303 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622006304 Zn2+ binding site [ion binding]; other site 515622006305 Mg2+ binding site [ion binding]; other site 515622006306 oligoendopeptidase F; Region: pepF; TIGR00181 515622006307 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 515622006308 active site 515622006309 Zn binding site [ion binding]; other site 515622006310 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 515622006311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622006312 FeS/SAM binding site; other site 515622006313 HemN C-terminal domain; Region: HemN_C; pfam06969 515622006314 GTP-binding protein LepA; Provisional; Region: PRK05433 515622006315 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 515622006316 G1 box; other site 515622006317 putative GEF interaction site [polypeptide binding]; other site 515622006318 GTP/Mg2+ binding site [chemical binding]; other site 515622006319 Switch I region; other site 515622006320 G2 box; other site 515622006321 G3 box; other site 515622006322 Switch II region; other site 515622006323 G4 box; other site 515622006324 G5 box; other site 515622006325 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 515622006326 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 515622006327 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 515622006328 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 515622006329 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 515622006330 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515622006331 TIGR03943 family protein; Region: TIGR03943 515622006332 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 515622006333 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 515622006334 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 515622006335 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 515622006336 B-Box C-terminal domain; Region: BBC; smart00502 515622006337 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 515622006338 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 515622006339 Ferredoxin [Energy production and conversion]; Region: COG1146 515622006340 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 515622006341 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 515622006342 electron transport complex RsxE subunit; Provisional; Region: PRK12405 515622006343 FMN-binding domain; Region: FMN_bind; cl01081 515622006344 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 515622006345 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 515622006346 SLBB domain; Region: SLBB; pfam10531 515622006347 RNase_H superfamily; Region: RNase_H_2; pfam13482 515622006348 active site 515622006349 catalytic site [active] 515622006350 substrate binding site [chemical binding]; other site 515622006351 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 515622006352 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 515622006353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622006354 Protein of unknown function (DUF342); Region: DUF342; pfam03961 515622006355 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 515622006356 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 515622006357 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 515622006358 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 515622006359 RNA binding site [nucleotide binding]; other site 515622006360 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 515622006361 RNA binding site [nucleotide binding]; other site 515622006362 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 515622006363 RNA binding site [nucleotide binding]; other site 515622006364 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 515622006365 RNA binding site [nucleotide binding]; other site 515622006366 LytB protein; Region: LYTB; cl00507 515622006367 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 515622006368 cytidylate kinase; Provisional; Region: cmk; PRK00023 515622006369 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 515622006370 CMP-binding site; other site 515622006371 The sites determining sugar specificity; other site 515622006372 flavoprotein, HI0933 family; Region: TIGR00275 515622006373 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 515622006374 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 515622006375 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 515622006376 putative active site [active] 515622006377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622006378 WHG domain; Region: WHG; pfam13305 515622006379 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 515622006380 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 515622006381 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622006382 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622006383 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622006384 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 515622006385 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 515622006386 active site 515622006387 catalytic site [active] 515622006388 metal binding site [ion binding]; metal-binding site 515622006389 dimer interface [polypeptide binding]; other site 515622006390 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 515622006391 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 515622006392 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 515622006393 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 515622006394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515622006395 ATP binding site [chemical binding]; other site 515622006396 putative Mg++ binding site [ion binding]; other site 515622006397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515622006398 nucleotide binding region [chemical binding]; other site 515622006399 ATP-binding site [chemical binding]; other site 515622006400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622006401 active site 515622006402 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 515622006403 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 515622006404 MgtC family; Region: MgtC; pfam02308 515622006405 shikimate kinase; Reviewed; Region: aroK; PRK00131 515622006406 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 515622006407 ADP binding site [chemical binding]; other site 515622006408 magnesium binding site [ion binding]; other site 515622006409 putative shikimate binding site; other site 515622006410 triosephosphate isomerase; Provisional; Region: PRK14567 515622006411 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 515622006412 substrate binding site [chemical binding]; other site 515622006413 dimer interface [polypeptide binding]; other site 515622006414 catalytic triad [active] 515622006415 Phosphoglycerate kinase; Region: PGK; pfam00162 515622006416 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 515622006417 substrate binding site [chemical binding]; other site 515622006418 hinge regions; other site 515622006419 ADP binding site [chemical binding]; other site 515622006420 catalytic site [active] 515622006421 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 515622006422 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 515622006423 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 515622006424 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 515622006425 histidinol-phosphatase; Provisional; Region: PRK05588 515622006426 active site 515622006427 dimer interface [polypeptide binding]; other site 515622006428 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622006429 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622006430 metal binding site [ion binding]; metal-binding site 515622006431 active site 515622006432 I-site; other site 515622006433 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 515622006434 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 515622006435 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 515622006436 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 515622006437 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 515622006438 Response regulator receiver domain; Region: Response_reg; pfam00072 515622006439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622006440 active site 515622006441 phosphorylation site [posttranslational modification] 515622006442 intermolecular recognition site; other site 515622006443 dimerization interface [polypeptide binding]; other site 515622006444 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 515622006445 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 515622006446 Flavoprotein; Region: Flavoprotein; pfam02441 515622006447 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 515622006448 Pantothenate kinase type III (Bvg accessory factor family protein) [Transcription]; Region: COG1521 515622006449 Predicted membrane protein [Function unknown]; Region: COG4684 515622006450 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 515622006451 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 515622006452 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 515622006453 dimer interface [polypeptide binding]; other site 515622006454 active site 515622006455 metal binding site [ion binding]; metal-binding site 515622006456 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 515622006457 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 515622006458 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 515622006459 Walker A/P-loop; other site 515622006460 ATP binding site [chemical binding]; other site 515622006461 Q-loop/lid; other site 515622006462 ABC transporter signature motif; other site 515622006463 Walker B; other site 515622006464 D-loop; other site 515622006465 H-loop/switch region; other site 515622006466 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 515622006467 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 515622006468 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 515622006469 Walker A/P-loop; other site 515622006470 ATP binding site [chemical binding]; other site 515622006471 Q-loop/lid; other site 515622006472 ABC transporter signature motif; other site 515622006473 Walker B; other site 515622006474 D-loop; other site 515622006475 H-loop/switch region; other site 515622006476 hypothetical protein; Provisional; Region: PRK13661 515622006477 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622006478 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622006479 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 515622006480 Walker A/P-loop; other site 515622006481 ATP binding site [chemical binding]; other site 515622006482 Q-loop/lid; other site 515622006483 ABC transporter signature motif; other site 515622006484 Walker B; other site 515622006485 D-loop; other site 515622006486 H-loop/switch region; other site 515622006487 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622006488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622006489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622006490 Walker A/P-loop; other site 515622006491 ATP binding site [chemical binding]; other site 515622006492 Q-loop/lid; other site 515622006493 ABC transporter signature motif; other site 515622006494 Walker B; other site 515622006495 D-loop; other site 515622006496 H-loop/switch region; other site 515622006497 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 515622006498 MarR family; Region: MarR_2; pfam12802 515622006499 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 515622006500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622006501 Coenzyme A binding pocket [chemical binding]; other site 515622006502 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 515622006503 Bacterial PH domain; Region: DUF304; pfam03703 515622006504 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 515622006505 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 515622006506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622006507 Walker A motif; other site 515622006508 ATP binding site [chemical binding]; other site 515622006509 Walker B motif; other site 515622006510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622006511 Walker A motif; other site 515622006512 ATP binding site [chemical binding]; other site 515622006513 Walker B motif; other site 515622006514 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 515622006515 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 515622006516 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 515622006517 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 515622006518 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 515622006519 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 515622006520 minor groove reading motif; other site 515622006521 helix-hairpin-helix signature motif; other site 515622006522 substrate binding pocket [chemical binding]; other site 515622006523 active site 515622006524 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 515622006525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515622006526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515622006527 DNA binding residues [nucleotide binding] 515622006528 TIR domain; Region: TIR_2; pfam13676 515622006529 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 515622006530 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 515622006531 nucleotide binding site [chemical binding]; other site 515622006532 putative NEF/HSP70 interaction site [polypeptide binding]; other site 515622006533 SBD interface [polypeptide binding]; other site 515622006534 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 515622006535 HSP70 interaction site [polypeptide binding]; other site 515622006536 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 515622006537 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515622006538 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515622006539 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515622006540 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515622006541 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515622006542 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 515622006543 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515622006544 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622006545 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622006546 metal binding site [ion binding]; metal-binding site 515622006547 active site 515622006548 I-site; other site 515622006549 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 515622006550 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 515622006551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622006552 active site 515622006553 phosphorylation site [posttranslational modification] 515622006554 intermolecular recognition site; other site 515622006555 dimerization interface [polypeptide binding]; other site 515622006556 LytTr DNA-binding domain; Region: LytTR; smart00850 515622006557 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 515622006558 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 515622006559 CheC-like family; Region: CheC; pfam04509 515622006560 CheC-like family; Region: CheC; pfam04509 515622006561 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 515622006562 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 515622006563 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 515622006564 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 515622006565 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 515622006566 putative substrate binding site [chemical binding]; other site 515622006567 putative ATP binding site [chemical binding]; other site 515622006568 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 515622006569 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 515622006570 active site 515622006571 phosphorylation site [posttranslational modification] 515622006572 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 515622006573 active site 515622006574 P-loop; other site 515622006575 phosphorylation site [posttranslational modification] 515622006576 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 515622006577 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 515622006578 dimerization domain swap beta strand [polypeptide binding]; other site 515622006579 regulatory protein interface [polypeptide binding]; other site 515622006580 active site 515622006581 regulatory phosphorylation site [posttranslational modification]; other site 515622006582 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 515622006583 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 515622006584 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 515622006585 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 515622006586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 515622006587 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 515622006588 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 515622006589 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 515622006590 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 515622006591 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 515622006592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622006593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622006594 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 515622006595 CHASE2 domain; Region: CHASE2; pfam05226 515622006596 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 515622006597 cyclase homology domain; Region: CHD; cd07302 515622006598 nucleotidyl binding site; other site 515622006599 metal binding site [ion binding]; metal-binding site 515622006600 dimer interface [polypeptide binding]; other site 515622006601 FecR protein; Region: FecR; pfam04773 515622006602 GAF domain; Region: GAF; pfam01590 515622006603 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622006604 Zn2+ binding site [ion binding]; other site 515622006605 Mg2+ binding site [ion binding]; other site 515622006606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622006607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 515622006608 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 515622006609 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 515622006610 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622006611 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622006612 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622006613 dimer interface [polypeptide binding]; other site 515622006614 putative CheW interface [polypeptide binding]; other site 515622006615 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622006616 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 515622006617 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622006618 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622006619 DNA binding site [nucleotide binding] 515622006620 domain linker motif; other site 515622006621 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622006622 dimerization interface [polypeptide binding]; other site 515622006623 ligand binding site [chemical binding]; other site 515622006624 Cache domain; Region: Cache_1; pfam02743 515622006625 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622006626 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622006627 metal binding site [ion binding]; metal-binding site 515622006628 active site 515622006629 I-site; other site 515622006630 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 515622006631 active site 515622006632 catalytic triad [active] 515622006633 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 515622006634 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 515622006635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622006636 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 515622006637 Walker A/P-loop; other site 515622006638 ATP binding site [chemical binding]; other site 515622006639 Q-loop/lid; other site 515622006640 ABC transporter signature motif; other site 515622006641 Walker B; other site 515622006642 D-loop; other site 515622006643 H-loop/switch region; other site 515622006644 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622006645 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 515622006646 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 515622006647 active site 515622006648 Bacterial SH3 domain; Region: SH3_3; pfam08239 515622006649 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622006650 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622006651 metal binding site [ion binding]; metal-binding site 515622006652 active site 515622006653 I-site; other site 515622006654 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622006655 Zn2+ binding site [ion binding]; other site 515622006656 Mg2+ binding site [ion binding]; other site 515622006657 glutamate dehydrogenase; Provisional; Region: PRK09414 515622006658 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 515622006659 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 515622006660 NAD(P) binding site [chemical binding]; other site 515622006661 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515622006662 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515622006663 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 515622006664 Bacterial SH3 domain; Region: SH3_3; cl17532 515622006665 Bacterial SH3 domain; Region: SH3_3; pfam08239 515622006666 elongation factor P; Validated; Region: PRK00529 515622006667 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 515622006668 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 515622006669 RNA binding site [nucleotide binding]; other site 515622006670 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 515622006671 RNA binding site [nucleotide binding]; other site 515622006672 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 515622006673 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622006674 metal binding site [ion binding]; metal-binding site 515622006675 active site 515622006676 I-site; other site 515622006677 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622006678 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 515622006679 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 515622006680 Ligand Binding Site [chemical binding]; other site 515622006681 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 515622006682 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 515622006683 active site 515622006684 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622006685 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 515622006686 active site 515622006687 nucleotide binding site [chemical binding]; other site 515622006688 HIGH motif; other site 515622006689 KMSKS motif; other site 515622006690 Isochorismatase family; Region: Isochorismatase; pfam00857 515622006691 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 515622006692 catalytic triad [active] 515622006693 conserved cis-peptide bond; other site 515622006694 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 515622006695 nudix motif; other site 515622006696 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 515622006697 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 515622006698 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 515622006699 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 515622006700 HIGH motif; other site 515622006701 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 515622006702 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622006703 KMSKS motif; other site 515622006704 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 515622006705 tRNA binding surface [nucleotide binding]; other site 515622006706 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 515622006707 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 515622006708 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 515622006709 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 515622006710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622006711 TPR motif; other site 515622006712 binding surface 515622006713 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 515622006714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622006715 binding surface 515622006716 TPR motif; other site 515622006717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622006718 TPR motif; other site 515622006719 binding surface 515622006720 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 515622006721 homotrimer interaction site [polypeptide binding]; other site 515622006722 putative active site [active] 515622006723 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 515622006724 active site 515622006725 catalytic triad [active] 515622006726 oxyanion hole [active] 515622006727 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 515622006728 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 515622006729 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 515622006730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622006731 binding surface 515622006732 TPR motif; other site 515622006733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622006734 binding surface 515622006735 TPR motif; other site 515622006736 TPR repeat; Region: TPR_11; pfam13414 515622006737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515622006738 binding surface 515622006739 TPR motif; other site 515622006740 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 515622006741 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515622006742 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515622006743 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 515622006744 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622006745 active site 515622006746 HIGH motif; other site 515622006747 nucleotide binding site [chemical binding]; other site 515622006748 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 515622006749 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 515622006750 active site 515622006751 KMSKS motif; other site 515622006752 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 515622006753 tRNA binding surface [nucleotide binding]; other site 515622006754 anticodon binding site; other site 515622006755 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 515622006756 TPR repeat; Region: TPR_11; pfam13414 515622006757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 515622006758 binding surface 515622006759 TPR motif; other site 515622006760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622006761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622006762 metal binding site [ion binding]; metal-binding site 515622006763 active site 515622006764 I-site; other site 515622006765 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 515622006766 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 515622006767 DEAD_2; Region: DEAD_2; pfam06733 515622006768 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 515622006769 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 515622006770 regulatory protein interface [polypeptide binding]; other site 515622006771 regulatory phosphorylation site [posttranslational modification]; other site 515622006772 asparagine synthetase AsnA; Provisional; Region: PRK05425 515622006773 motif 1; other site 515622006774 dimer interface [polypeptide binding]; other site 515622006775 active site 515622006776 motif 2; other site 515622006777 motif 3; other site 515622006778 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 515622006779 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 515622006780 HflX GTPase family; Region: HflX; cd01878 515622006781 G1 box; other site 515622006782 GTP/Mg2+ binding site [chemical binding]; other site 515622006783 Switch I region; other site 515622006784 G2 box; other site 515622006785 G3 box; other site 515622006786 Switch II region; other site 515622006787 G4 box; other site 515622006788 G5 box; other site 515622006789 Transposase IS200 like; Region: Y1_Tnp; pfam01797 515622006790 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 515622006791 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 515622006792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622006793 salt bridge; other site 515622006794 non-specific DNA binding site [nucleotide binding]; other site 515622006795 sequence-specific DNA binding site [nucleotide binding]; other site 515622006796 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 515622006797 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 515622006798 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622006799 active site 515622006800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622006801 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 515622006802 FeS/SAM binding site; other site 515622006803 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 515622006804 Domain of unknown function (DUF955); Region: DUF955; pfam06114 515622006805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 515622006806 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 515622006807 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 515622006808 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 515622006809 Helix-turn-helix domain; Region: HTH_17; pfam12728 515622006810 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 515622006811 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 515622006812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622006813 active site 515622006814 Sporulation related domain; Region: SPOR; cl10051 515622006815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622006816 FeS/SAM binding site; other site 515622006817 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 515622006818 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 515622006819 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 515622006820 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 515622006821 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 515622006822 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622006823 active site 515622006824 putative glycosyl transferase; Provisional; Region: PRK10073 515622006825 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622006826 active site 515622006827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622006828 active site 515622006829 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 515622006830 Radical SAM superfamily; Region: Radical_SAM; pfam04055 515622006831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622006832 FeS/SAM binding site; other site 515622006833 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 515622006834 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 515622006835 putative trimer interface [polypeptide binding]; other site 515622006836 putative CoA binding site [chemical binding]; other site 515622006837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 515622006838 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 515622006839 acyl-activating enzyme (AAE) consensus motif; other site 515622006840 AMP binding site [chemical binding]; other site 515622006841 active site 515622006842 CoA binding site [chemical binding]; other site 515622006843 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 515622006844 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 515622006845 active site 515622006846 catalytic tetrad [active] 515622006847 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 515622006848 Phosphopantetheine attachment site; Region: PP-binding; cl09936 515622006849 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 515622006850 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 515622006851 PYR/PP interface [polypeptide binding]; other site 515622006852 dimer interface [polypeptide binding]; other site 515622006853 TPP binding site [chemical binding]; other site 515622006854 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515622006855 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 515622006856 TPP-binding site [chemical binding]; other site 515622006857 dimer interface [polypeptide binding]; other site 515622006858 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 515622006859 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 515622006860 PYR/PP interface [polypeptide binding]; other site 515622006861 dimer interface [polypeptide binding]; other site 515622006862 TPP binding site [chemical binding]; other site 515622006863 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515622006864 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 515622006865 TPP-binding site [chemical binding]; other site 515622006866 dimer interface [polypeptide binding]; other site 515622006867 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 515622006868 NAD(P) binding site [chemical binding]; other site 515622006869 catalytic residues [active] 515622006870 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 515622006871 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 515622006872 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622006873 inhibitor-cofactor binding pocket; inhibition site 515622006874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622006875 catalytic residue [active] 515622006876 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 515622006877 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 515622006878 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 515622006879 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 515622006880 TPR motif; other site 515622006881 TPR repeat; Region: TPR_11; pfam13414 515622006882 Tetratricopeptide repeat; Region: TPR_1; pfam00515 515622006883 binding surface 515622006884 von Willebrand factor type A domain; Region: VWA_2; pfam13519 515622006885 metal ion-dependent adhesion site (MIDAS); other site 515622006886 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 515622006887 metal ion-dependent adhesion site (MIDAS); other site 515622006888 Protein of unknown function DUF58; Region: DUF58; pfam01882 515622006889 MoxR-like ATPases [General function prediction only]; Region: COG0714 515622006890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622006891 Walker A motif; other site 515622006892 ATP binding site [chemical binding]; other site 515622006893 Walker B motif; other site 515622006894 arginine finger; other site 515622006895 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 515622006896 FAD binding site [chemical binding]; other site 515622006897 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 515622006898 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 515622006899 tetramer interface [polypeptide binding]; other site 515622006900 active site 515622006901 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 515622006902 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 515622006903 active site 515622006904 tetramer interface [polypeptide binding]; other site 515622006905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622006906 active site 515622006907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622006908 dimer interface [polypeptide binding]; other site 515622006909 conserved gate region; other site 515622006910 ABC-ATPase subunit interface; other site 515622006911 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 515622006912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622006913 Walker A/P-loop; other site 515622006914 ATP binding site [chemical binding]; other site 515622006915 Q-loop/lid; other site 515622006916 ABC transporter signature motif; other site 515622006917 Walker B; other site 515622006918 D-loop; other site 515622006919 H-loop/switch region; other site 515622006920 NIL domain; Region: NIL; pfam09383 515622006921 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 515622006922 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 515622006923 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 515622006924 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 515622006925 FtsX-like permease family; Region: FtsX; pfam02687 515622006926 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 515622006927 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 515622006928 FtsX-like permease family; Region: FtsX; pfam02687 515622006929 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 515622006930 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 515622006931 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 515622006932 HlyD family secretion protein; Region: HlyD_3; pfam13437 515622006933 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 515622006934 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 515622006935 Walker A/P-loop; other site 515622006936 ATP binding site [chemical binding]; other site 515622006937 Q-loop/lid; other site 515622006938 ABC transporter signature motif; other site 515622006939 Walker B; other site 515622006940 D-loop; other site 515622006941 H-loop/switch region; other site 515622006942 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 515622006943 hypothetical protein; Provisional; Region: PRK11770 515622006944 Domain of unknown function (DUF307); Region: DUF307; pfam03733 515622006945 Domain of unknown function (DUF307); Region: DUF307; pfam03733 515622006946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622006947 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 515622006948 Coenzyme A binding pocket [chemical binding]; other site 515622006949 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 515622006950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622006951 motif II; other site 515622006952 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 515622006953 active site 515622006954 ATP binding site [chemical binding]; other site 515622006955 Phosphotransferase enzyme family; Region: APH; pfam01636 515622006956 antibiotic binding site [chemical binding]; other site 515622006957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622006958 Coenzyme A binding pocket [chemical binding]; other site 515622006959 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 515622006960 AAA domain; Region: AAA_14; pfam13173 515622006961 HD domain; Region: HD_3; pfam13023 515622006962 YcxB-like protein; Region: YcxB; pfam14317 515622006963 Chloramphenicol acetyltransferase; Region: CAT; cl02008 515622006964 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 515622006965 Phosphotransferase enzyme family; Region: APH; pfam01636 515622006966 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622006967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622006968 non-specific DNA binding site [nucleotide binding]; other site 515622006969 salt bridge; other site 515622006970 sequence-specific DNA binding site [nucleotide binding]; other site 515622006971 TPR repeat; Region: TPR_11; pfam13414 515622006972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 515622006973 TPR motif; other site 515622006974 H+ Antiporter protein; Region: 2A0121; TIGR00900 515622006975 Radical SAM superfamily; Region: Radical_SAM; pfam04055 515622006976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 515622006977 FeS/SAM binding site; other site 515622006978 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 515622006979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622006980 Walker A/P-loop; other site 515622006981 ATP binding site [chemical binding]; other site 515622006982 Q-loop/lid; other site 515622006983 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 515622006984 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 515622006985 active site 515622006986 metal binding site [ion binding]; metal-binding site 515622006987 conserved hypothetical protein; Region: MG423; TIGR00649 515622006988 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 515622006989 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 515622006990 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622006991 Walker A motif; other site 515622006992 ATP binding site [chemical binding]; other site 515622006993 Walker B motif; other site 515622006994 semaphorin domain; Region: Sema; smart00630 515622006995 stage V sporulation protein K; Region: spore_V_K; TIGR02881 515622006996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622006997 Walker A motif; other site 515622006998 ATP binding site [chemical binding]; other site 515622006999 Walker B motif; other site 515622007000 arginine finger; other site 515622007001 heat shock protein 90; Provisional; Region: PRK05218 515622007002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622007003 ATP binding site [chemical binding]; other site 515622007004 Mg2+ binding site [ion binding]; other site 515622007005 G-X-G motif; other site 515622007006 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622007007 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622007008 ligand binding site [chemical binding]; other site 515622007009 dimerization interface [polypeptide binding]; other site 515622007010 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622007011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622007012 metal binding site [ion binding]; metal-binding site 515622007013 active site 515622007014 I-site; other site 515622007015 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 515622007016 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 515622007017 lycopene cyclase; Region: lycopene_cycl; TIGR01789 515622007018 2-isopropylmalate synthase; Validated; Region: PRK03739 515622007019 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 515622007020 active site 515622007021 catalytic residues [active] 515622007022 metal binding site [ion binding]; metal-binding site 515622007023 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 515622007024 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622007025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622007026 ACT domain-containing protein [General function prediction only]; Region: COG4747 515622007027 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 515622007028 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 515622007029 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 515622007030 active site 515622007031 Part of AAA domain; Region: AAA_19; pfam13245 515622007032 Family description; Region: UvrD_C_2; pfam13538 515622007033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622007034 Walker A motif; other site 515622007035 ATP binding site [chemical binding]; other site 515622007036 Walker B motif; other site 515622007037 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 515622007038 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 515622007039 metal ion-dependent adhesion site (MIDAS); other site 515622007040 sucrose phosphorylase; Provisional; Region: PRK13840 515622007041 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 515622007042 active site 515622007043 catalytic site [active] 515622007044 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622007045 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622007046 DNA binding site [nucleotide binding] 515622007047 domain linker motif; other site 515622007048 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622007049 ligand binding site [chemical binding]; other site 515622007050 dimerization interface [polypeptide binding]; other site 515622007051 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515622007052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622007053 dimer interface [polypeptide binding]; other site 515622007054 conserved gate region; other site 515622007055 putative PBP binding loops; other site 515622007056 ABC-ATPase subunit interface; other site 515622007057 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622007058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622007059 dimer interface [polypeptide binding]; other site 515622007060 conserved gate region; other site 515622007061 putative PBP binding loops; other site 515622007062 ABC-ATPase subunit interface; other site 515622007063 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 515622007064 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622007065 active site 515622007066 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 515622007067 Bacterial SH3 domain; Region: SH3_3; pfam08239 515622007068 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 515622007069 active site 515622007070 catalytic triad [active] 515622007071 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 515622007072 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 515622007073 glutaminase active site [active] 515622007074 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 515622007075 dimer interface [polypeptide binding]; other site 515622007076 active site 515622007077 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 515622007078 dimer interface [polypeptide binding]; other site 515622007079 active site 515622007080 PilZ domain; Region: PilZ; pfam07238 515622007081 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622007082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622007083 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 515622007084 Walker A/P-loop; other site 515622007085 ATP binding site [chemical binding]; other site 515622007086 Q-loop/lid; other site 515622007087 ABC transporter signature motif; other site 515622007088 Walker B; other site 515622007089 D-loop; other site 515622007090 H-loop/switch region; other site 515622007091 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622007092 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622007093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622007094 Walker A/P-loop; other site 515622007095 ATP binding site [chemical binding]; other site 515622007096 Q-loop/lid; other site 515622007097 ABC transporter signature motif; other site 515622007098 Walker B; other site 515622007099 D-loop; other site 515622007100 H-loop/switch region; other site 515622007101 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622007102 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622007103 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622007104 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622007105 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 515622007106 Intron encoded nuclease repeat motif; Region: IENR1; smart00497 515622007107 Ion transport protein; Region: Ion_trans; pfam00520 515622007108 Ion channel; Region: Ion_trans_2; pfam07885 515622007109 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 515622007110 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 515622007111 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 515622007112 Malic enzyme, N-terminal domain; Region: malic; pfam00390 515622007113 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 515622007114 putative NAD(P) binding site [chemical binding]; other site 515622007115 recombination factor protein RarA; Reviewed; Region: PRK13342 515622007116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622007117 Walker A motif; other site 515622007118 ATP binding site [chemical binding]; other site 515622007119 Walker B motif; other site 515622007120 arginine finger; other site 515622007121 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 515622007122 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622007123 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 515622007124 radical SAM protein, TIGR01212 family; Region: TIGR01212 515622007125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622007126 FeS/SAM binding site; other site 515622007127 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 515622007128 Uncharacterized conserved protein [Function unknown]; Region: COG2006 515622007129 Domain of unknown function (DUF362); Region: DUF362; pfam04015 515622007130 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 515622007131 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 515622007132 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515622007133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622007134 Zn2+ binding site [ion binding]; other site 515622007135 Mg2+ binding site [ion binding]; other site 515622007136 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 515622007137 protein-splicing catalytic site; other site 515622007138 thioester formation/cholesterol transfer; other site 515622007139 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 515622007140 putative lipid kinase; Reviewed; Region: PRK13337 515622007141 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 515622007142 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 515622007143 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 515622007144 folate binding site [chemical binding]; other site 515622007145 NADP+ binding site [chemical binding]; other site 515622007146 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 515622007147 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 515622007148 dimerization interface [polypeptide binding]; other site 515622007149 active site 515622007150 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 515622007151 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515622007152 Beta-Casp domain; Region: Beta-Casp; smart01027 515622007153 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 515622007154 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 515622007155 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 515622007156 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 515622007157 G1 box; other site 515622007158 GTP/Mg2+ binding site [chemical binding]; other site 515622007159 Switch I region; other site 515622007160 G2 box; other site 515622007161 G3 box; other site 515622007162 Switch II region; other site 515622007163 G4 box; other site 515622007164 G5 box; other site 515622007165 Nucleoside recognition; Region: Gate; pfam07670 515622007166 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 515622007167 Nucleoside recognition; Region: Gate; pfam07670 515622007168 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 515622007169 TraX protein; Region: TraX; pfam05857 515622007170 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 515622007171 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 515622007172 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 515622007173 TrkA-N domain; Region: TrkA_N; pfam02254 515622007174 TrkA-C domain; Region: TrkA_C; pfam02080 515622007175 TrkA-N domain; Region: TrkA_N; pfam02254 515622007176 TrkA-C domain; Region: TrkA_C; pfam02080 515622007177 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 515622007178 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 515622007179 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 515622007180 putative active site [active] 515622007181 putative metal binding site [ion binding]; other site 515622007182 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 515622007183 mRNA/rRNA interface [nucleotide binding]; other site 515622007184 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 515622007185 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 515622007186 23S rRNA interface [nucleotide binding]; other site 515622007187 L7/L12 interface [polypeptide binding]; other site 515622007188 putative thiostrepton binding site; other site 515622007189 L25 interface [polypeptide binding]; other site 515622007190 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 515622007191 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 515622007192 putative homodimer interface [polypeptide binding]; other site 515622007193 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 515622007194 heterodimer interface [polypeptide binding]; other site 515622007195 homodimer interface [polypeptide binding]; other site 515622007196 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 515622007197 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 515622007198 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 515622007199 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 515622007200 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 515622007201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 515622007202 UDP-galactopyranose mutase; Region: GLF; pfam03275 515622007203 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 515622007204 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 515622007205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622007206 active site 515622007207 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622007208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622007209 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 515622007210 NAD(P) binding site [chemical binding]; other site 515622007211 active site 515622007212 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 515622007213 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622007214 inhibitor-cofactor binding pocket; inhibition site 515622007215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622007216 catalytic residue [active] 515622007217 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 515622007218 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 515622007219 NAD binding site [chemical binding]; other site 515622007220 homotetramer interface [polypeptide binding]; other site 515622007221 homodimer interface [polypeptide binding]; other site 515622007222 substrate binding site [chemical binding]; other site 515622007223 active site 515622007224 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 515622007225 putative metal binding site; other site 515622007226 Sel1-like repeats; Region: SEL1; smart00671 515622007227 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 515622007228 Protein of unknown function DUF58; Region: DUF58; pfam01882 515622007229 MoxR-like ATPases [General function prediction only]; Region: COG0714 515622007230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622007231 Walker A motif; other site 515622007232 ATP binding site [chemical binding]; other site 515622007233 Walker B motif; other site 515622007234 arginine finger; other site 515622007235 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622007236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622007237 metal binding site [ion binding]; metal-binding site 515622007238 active site 515622007239 I-site; other site 515622007240 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 515622007241 substrate binding site [chemical binding]; other site 515622007242 active site 515622007243 peptide chain release factor 2; Validated; Region: prfB; PRK00578 515622007244 PCRF domain; Region: PCRF; pfam03462 515622007245 RF-1 domain; Region: RF-1; pfam00472 515622007246 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 515622007247 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 515622007248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515622007249 nucleotide binding region [chemical binding]; other site 515622007250 ATP-binding site [chemical binding]; other site 515622007251 SEC-C motif; Region: SEC-C; pfam02810 515622007252 butyrate kinase; Provisional; Region: PRK03011 515622007253 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 515622007254 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 515622007255 non-specific DNA interactions [nucleotide binding]; other site 515622007256 DNA binding site [nucleotide binding] 515622007257 sequence specific DNA binding site [nucleotide binding]; other site 515622007258 putative cAMP binding site [chemical binding]; other site 515622007259 D-allose kinase; Provisional; Region: PRK09698 515622007260 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 515622007261 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 515622007262 active site 515622007263 catalytic residues [active] 515622007264 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622007265 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622007266 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 515622007267 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622007268 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622007269 active site 515622007270 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 515622007271 Carbon starvation protein CstA; Region: CstA; pfam02554 515622007272 Carbon starvation protein CstA; Region: CstA; pfam02554 515622007273 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 515622007274 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 515622007275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 515622007276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622007277 homodimer interface [polypeptide binding]; other site 515622007278 catalytic residue [active] 515622007279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 515622007280 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 515622007281 Probable transposase; Region: OrfB_IS605; pfam01385 515622007282 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 515622007283 Transposase IS200 like; Region: Y1_Tnp; pfam01797 515622007284 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 515622007285 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 515622007286 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622007287 active site 515622007288 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 515622007289 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 515622007290 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 515622007291 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 515622007292 Glutamine amidotransferase class-I; Region: GATase; pfam00117 515622007293 glutamine binding [chemical binding]; other site 515622007294 catalytic triad [active] 515622007295 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 515622007296 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 515622007297 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 515622007298 ANTAR domain; Region: ANTAR; pfam03861 515622007299 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 515622007300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622007301 active site 515622007302 phosphorylation site [posttranslational modification] 515622007303 intermolecular recognition site; other site 515622007304 dimerization interface [polypeptide binding]; other site 515622007305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622007306 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 515622007307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622007308 dimerization interface [polypeptide binding]; other site 515622007309 Histidine kinase; Region: His_kinase; pfam06580 515622007310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622007311 ATP binding site [chemical binding]; other site 515622007312 Mg2+ binding site [ion binding]; other site 515622007313 G-X-G motif; other site 515622007314 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515622007315 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622007316 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622007317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622007318 dimer interface [polypeptide binding]; other site 515622007319 conserved gate region; other site 515622007320 putative PBP binding loops; other site 515622007321 ABC-ATPase subunit interface; other site 515622007322 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622007323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622007324 conserved gate region; other site 515622007325 putative PBP binding loops; other site 515622007326 ABC-ATPase subunit interface; other site 515622007327 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622007328 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622007329 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 515622007330 Predicted membrane protein [Function unknown]; Region: COG2364 515622007331 Uncharacterized conserved protein [Function unknown]; Region: COG5663 515622007332 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 515622007333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515622007334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515622007335 DNA binding residues [nucleotide binding] 515622007336 Phosphotransferase enzyme family; Region: APH; pfam01636 515622007337 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 515622007338 active site 515622007339 ATP binding site [chemical binding]; other site 515622007340 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 515622007341 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 515622007342 putative active site [active] 515622007343 nucleotide binding site [chemical binding]; other site 515622007344 nudix motif; other site 515622007345 putative metal binding site [ion binding]; other site 515622007346 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 515622007347 putative active site [active] 515622007348 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 515622007349 nudix motif; other site 515622007350 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 515622007351 Double zinc ribbon; Region: DZR; pfam12773 515622007352 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 515622007353 Double zinc ribbon; Region: DZR; pfam12773 515622007354 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 515622007355 Double zinc ribbon; Region: DZR; pfam12773 515622007356 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 515622007357 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 515622007358 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 515622007359 Double zinc ribbon; Region: DZR; pfam12773 515622007360 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 515622007361 elongation factor Tu; Reviewed; Region: PRK00049 515622007362 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 515622007363 G1 box; other site 515622007364 GEF interaction site [polypeptide binding]; other site 515622007365 GTP/Mg2+ binding site [chemical binding]; other site 515622007366 Switch I region; other site 515622007367 G2 box; other site 515622007368 G3 box; other site 515622007369 Switch II region; other site 515622007370 G4 box; other site 515622007371 G5 box; other site 515622007372 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 515622007373 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 515622007374 Antibiotic Binding Site [chemical binding]; other site 515622007375 elongation factor G; Reviewed; Region: PRK00007 515622007376 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 515622007377 G1 box; other site 515622007378 putative GEF interaction site [polypeptide binding]; other site 515622007379 GTP/Mg2+ binding site [chemical binding]; other site 515622007380 Switch I region; other site 515622007381 G2 box; other site 515622007382 G3 box; other site 515622007383 Switch II region; other site 515622007384 G4 box; other site 515622007385 G5 box; other site 515622007386 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 515622007387 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 515622007388 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 515622007389 30S ribosomal protein S7; Validated; Region: PRK05302 515622007390 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 515622007391 S17 interaction site [polypeptide binding]; other site 515622007392 S8 interaction site; other site 515622007393 16S rRNA interaction site [nucleotide binding]; other site 515622007394 streptomycin interaction site [chemical binding]; other site 515622007395 23S rRNA interaction site [nucleotide binding]; other site 515622007396 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 515622007397 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 515622007398 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 515622007399 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 515622007400 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 515622007401 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 515622007402 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 515622007403 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 515622007404 G-loop; other site 515622007405 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 515622007406 DNA binding site [nucleotide binding] 515622007407 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 515622007408 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 515622007409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 515622007410 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 515622007411 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 515622007412 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 515622007413 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 515622007414 RPB1 interaction site [polypeptide binding]; other site 515622007415 RPB10 interaction site [polypeptide binding]; other site 515622007416 RPB11 interaction site [polypeptide binding]; other site 515622007417 RPB3 interaction site [polypeptide binding]; other site 515622007418 RPB12 interaction site [polypeptide binding]; other site 515622007419 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 515622007420 core dimer interface [polypeptide binding]; other site 515622007421 peripheral dimer interface [polypeptide binding]; other site 515622007422 L10 interface [polypeptide binding]; other site 515622007423 L11 interface [polypeptide binding]; other site 515622007424 putative EF-Tu interaction site [polypeptide binding]; other site 515622007425 putative EF-G interaction site [polypeptide binding]; other site 515622007426 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 515622007427 23S rRNA interface [nucleotide binding]; other site 515622007428 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 515622007429 Pectate lyase; Region: Pec_lyase_C; cl01593 515622007430 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622007431 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622007432 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622007433 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 515622007434 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 515622007435 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 515622007436 active site 515622007437 dimer interface [polypeptide binding]; other site 515622007438 motif 1; other site 515622007439 motif 2; other site 515622007440 motif 3; other site 515622007441 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 515622007442 anticodon binding site; other site 515622007443 hypothetical protein; Provisional; Region: PRK05590 515622007444 SEC-C motif; Region: SEC-C; pfam02810 515622007445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622007446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622007447 dimer interface [polypeptide binding]; other site 515622007448 phosphorylation site [posttranslational modification] 515622007449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622007450 ATP binding site [chemical binding]; other site 515622007451 Mg2+ binding site [ion binding]; other site 515622007452 G-X-G motif; other site 515622007453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622007454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622007455 active site 515622007456 phosphorylation site [posttranslational modification] 515622007457 intermolecular recognition site; other site 515622007458 dimerization interface [polypeptide binding]; other site 515622007459 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622007460 DNA binding site [nucleotide binding] 515622007461 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 515622007462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622007463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622007464 Walker A/P-loop; other site 515622007465 ATP binding site [chemical binding]; other site 515622007466 Q-loop/lid; other site 515622007467 ABC transporter signature motif; other site 515622007468 Walker B; other site 515622007469 D-loop; other site 515622007470 H-loop/switch region; other site 515622007471 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 515622007472 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 515622007473 active site 515622007474 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622007475 Ligand Binding Site [chemical binding]; other site 515622007476 Molecular Tunnel; other site 515622007477 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 515622007478 active site 515622007479 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622007480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622007481 active site 515622007482 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 515622007483 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 515622007484 Bacterial sugar transferase; Region: Bac_transf; pfam02397 515622007485 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 515622007486 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 515622007487 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 515622007488 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 515622007489 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 515622007490 Methyltransferase domain; Region: Methyltransf_31; pfam13847 515622007491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622007492 S-adenosylmethionine binding site [chemical binding]; other site 515622007493 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 515622007494 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 515622007495 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 515622007496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622007497 homodimer interface [polypeptide binding]; other site 515622007498 catalytic residue [active] 515622007499 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 515622007500 active site 515622007501 catalytic site [active] 515622007502 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 515622007503 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 515622007504 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515622007505 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 515622007506 Chain length determinant protein; Region: Wzz; cl15801 515622007507 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 515622007508 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 515622007509 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 515622007510 Clp amino terminal domain; Region: Clp_N; pfam02861 515622007511 Clp amino terminal domain; Region: Clp_N; pfam02861 515622007512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622007513 Walker A motif; other site 515622007514 ATP binding site [chemical binding]; other site 515622007515 Walker B motif; other site 515622007516 arginine finger; other site 515622007517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622007518 Walker A motif; other site 515622007519 ATP binding site [chemical binding]; other site 515622007520 Walker B motif; other site 515622007521 arginine finger; other site 515622007522 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 515622007523 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 515622007524 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 515622007525 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 515622007526 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 515622007527 Ligand binding site; other site 515622007528 metal-binding site 515622007529 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 515622007530 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 515622007531 G1 box; other site 515622007532 GTP/Mg2+ binding site [chemical binding]; other site 515622007533 Switch I region; other site 515622007534 G2 box; other site 515622007535 G3 box; other site 515622007536 Switch II region; other site 515622007537 G4 box; other site 515622007538 G5 box; other site 515622007539 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 515622007540 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 515622007541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622007542 Walker A motif; other site 515622007543 ATP binding site [chemical binding]; other site 515622007544 Walker B motif; other site 515622007545 arginine finger; other site 515622007546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 515622007547 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 515622007548 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 515622007549 oligomer interface [polypeptide binding]; other site 515622007550 active site residues [active] 515622007551 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 515622007552 trigger factor; Provisional; Region: tig; PRK01490 515622007553 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 515622007554 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 515622007555 Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761 515622007556 putative active site [active] 515622007557 putative metal binding residues [ion binding]; other site 515622007558 signature motif; other site 515622007559 putative dimer interface [polypeptide binding]; other site 515622007560 putative phosphate binding site [ion binding]; other site 515622007561 DJ-1 family protein; Region: not_thiJ; TIGR01383 515622007562 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 515622007563 conserved cys residue [active] 515622007564 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 515622007565 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 515622007566 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 515622007567 active site 515622007568 Substrate binding site; other site 515622007569 Mg++ binding site; other site 515622007570 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 515622007571 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 515622007572 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 515622007573 65 kDa invariant surface glycoprotein; Provisional; Region: PTZ00208 515622007574 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 515622007575 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 515622007576 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 515622007577 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 515622007578 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 515622007579 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622007580 active site 515622007581 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 515622007582 CotH protein; Region: CotH; pfam08757 515622007583 VanZ like family; Region: VanZ; pfam04892 515622007584 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622007585 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 515622007586 Probable Catalytic site; other site 515622007587 Chain length determinant protein; Region: Wzz; cl15801 515622007588 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 515622007589 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515622007590 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 515622007591 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622007592 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 515622007593 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622007594 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 515622007595 active site 515622007596 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 515622007597 DNA polymerase III subunit delta'; Validated; Region: PRK07276 515622007598 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622007599 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622007600 DNA binding site [nucleotide binding] 515622007601 domain linker motif; other site 515622007602 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622007603 ligand binding site [chemical binding]; other site 515622007604 dimerization interface [polypeptide binding]; other site 515622007605 4-alpha-glucanotransferase; Provisional; Region: PRK14508 515622007606 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 515622007607 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 515622007608 substrate binding site [chemical binding]; other site 515622007609 ATP binding site [chemical binding]; other site 515622007610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622007611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622007612 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622007613 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622007614 active site 515622007615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 515622007616 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 515622007617 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 515622007618 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622007619 active site 515622007620 HIGH motif; other site 515622007621 nucleotide binding site [chemical binding]; other site 515622007622 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622007623 active site 515622007624 KMSKS motif; other site 515622007625 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 515622007626 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622007627 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622007628 metal binding site [ion binding]; metal-binding site 515622007629 active site 515622007630 I-site; other site 515622007631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622007632 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 515622007633 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 515622007634 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 515622007635 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 515622007636 active site 515622007637 4-hydroxyphenylpyruvate dioxygenase; Region: PLN02875 515622007638 aspartate kinase; Reviewed; Region: PRK09034 515622007639 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 515622007640 nucleotide binding site [chemical binding]; other site 515622007641 substrate binding site [chemical binding]; other site 515622007642 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 515622007643 allosteric regulatory residue; other site 515622007644 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 515622007645 homoserine dehydrogenase; Provisional; Region: PRK06349 515622007646 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 515622007647 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 515622007648 hypothetical protein; Provisional; Region: PRK04435 515622007649 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 515622007650 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622007651 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 515622007652 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622007653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622007654 dimer interface [polypeptide binding]; other site 515622007655 conserved gate region; other site 515622007656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 515622007657 ABC-ATPase subunit interface; other site 515622007658 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622007659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622007660 dimer interface [polypeptide binding]; other site 515622007661 conserved gate region; other site 515622007662 putative PBP binding loops; other site 515622007663 ABC-ATPase subunit interface; other site 515622007664 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622007665 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622007666 DNA binding site [nucleotide binding] 515622007667 domain linker motif; other site 515622007668 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622007669 dimerization interface [polypeptide binding]; other site 515622007670 ligand binding site [chemical binding]; other site 515622007671 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 515622007672 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 515622007673 catalytic domain interface [polypeptide binding]; other site 515622007674 homodimer interface [polypeptide binding]; other site 515622007675 putative active site [active] 515622007676 Peptidase family M23; Region: Peptidase_M23; pfam01551 515622007677 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 515622007678 Trp repressor protein; Region: Trp_repressor; cl17266 515622007679 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 515622007680 DNA-binding site [nucleotide binding]; DNA binding site 515622007681 RNA-binding motif; other site 515622007682 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 515622007683 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 515622007684 active site 515622007685 dihydrodipicolinate reductase; Provisional; Region: PRK00048 515622007686 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 515622007687 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 515622007688 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 515622007689 dihydrodipicolinate synthase; Region: dapA; TIGR00674 515622007690 dimer interface [polypeptide binding]; other site 515622007691 active site 515622007692 catalytic residue [active] 515622007693 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 515622007694 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 515622007695 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 515622007696 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 515622007697 G1 box; other site 515622007698 putative GEF interaction site [polypeptide binding]; other site 515622007699 GTP/Mg2+ binding site [chemical binding]; other site 515622007700 Switch I region; other site 515622007701 G2 box; other site 515622007702 G3 box; other site 515622007703 Switch II region; other site 515622007704 G4 box; other site 515622007705 G5 box; other site 515622007706 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 515622007707 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 515622007708 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 515622007709 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 515622007710 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 515622007711 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 515622007712 Transglycosylase; Region: Transgly; pfam00912 515622007713 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 515622007714 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 515622007715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622007716 FeS/SAM binding site; other site 515622007717 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 515622007718 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622007719 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 515622007720 active site residue [active] 515622007721 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 515622007722 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 515622007723 Ligand Binding Site [chemical binding]; other site 515622007724 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 515622007725 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 515622007726 Walker A/P-loop; other site 515622007727 ATP binding site [chemical binding]; other site 515622007728 Q-loop/lid; other site 515622007729 ABC transporter signature motif; other site 515622007730 Walker B; other site 515622007731 D-loop; other site 515622007732 H-loop/switch region; other site 515622007733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622007734 dimer interface [polypeptide binding]; other site 515622007735 conserved gate region; other site 515622007736 putative PBP binding loops; other site 515622007737 ABC-ATPase subunit interface; other site 515622007738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622007739 dimer interface [polypeptide binding]; other site 515622007740 conserved gate region; other site 515622007741 putative PBP binding loops; other site 515622007742 ABC-ATPase subunit interface; other site 515622007743 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 515622007744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515622007745 substrate binding pocket [chemical binding]; other site 515622007746 membrane-bound complex binding site; other site 515622007747 hinge residues; other site 515622007748 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 515622007749 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 515622007750 homodimer interface [polypeptide binding]; other site 515622007751 substrate-cofactor binding pocket; other site 515622007752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622007753 catalytic residue [active] 515622007754 Rrf2 family protein; Region: rrf2_super; TIGR00738 515622007755 Transcriptional regulator; Region: Rrf2; pfam02082 515622007756 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 515622007757 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 515622007758 active site 515622007759 metal binding site [ion binding]; metal-binding site 515622007760 homotetramer interface [polypeptide binding]; other site 515622007761 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 515622007762 active site 515622007763 dimerization interface [polypeptide binding]; other site 515622007764 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 515622007765 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 515622007766 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 515622007767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 515622007768 putative pectinesterase; Region: PLN02432; cl01911 515622007769 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622007770 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622007771 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 515622007772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622007773 active site 515622007774 phosphorylation site [posttranslational modification] 515622007775 intermolecular recognition site; other site 515622007776 dimerization interface [polypeptide binding]; other site 515622007777 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622007778 Zn2+ binding site [ion binding]; other site 515622007779 Mg2+ binding site [ion binding]; other site 515622007780 putative acyltransferase; Provisional; Region: PRK05790 515622007781 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 515622007782 dimer interface [polypeptide binding]; other site 515622007783 active site 515622007784 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 515622007785 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 515622007786 Walker A/P-loop; other site 515622007787 ATP binding site [chemical binding]; other site 515622007788 Q-loop/lid; other site 515622007789 ABC transporter signature motif; other site 515622007790 Walker B; other site 515622007791 D-loop; other site 515622007792 H-loop/switch region; other site 515622007793 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 515622007794 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 515622007795 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 515622007796 PDGLE domain; Region: PDGLE; pfam13190 515622007797 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 515622007798 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 515622007799 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 515622007800 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 515622007801 A new structural DNA glycosylase; Region: AlkD_like; cd06561 515622007802 active site 515622007803 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 515622007804 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 515622007805 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 515622007806 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 515622007807 Ligand binding site [chemical binding]; other site 515622007808 Electron transfer flavoprotein domain; Region: ETF; pfam01012 515622007809 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 515622007810 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 515622007811 FAD binding site [chemical binding]; other site 515622007812 homotetramer interface [polypeptide binding]; other site 515622007813 substrate binding pocket [chemical binding]; other site 515622007814 catalytic base [active] 515622007815 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 515622007816 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 515622007817 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 515622007818 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 515622007819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 515622007820 substrate binding site [chemical binding]; other site 515622007821 oxyanion hole (OAH) forming residues; other site 515622007822 trimer interface [polypeptide binding]; other site 515622007823 putative acyltransferase; Provisional; Region: PRK05790 515622007824 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 515622007825 dimer interface [polypeptide binding]; other site 515622007826 active site 515622007827 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 515622007828 30S subunit binding site; other site 515622007829 Bacterial SH3 domain; Region: SH3_3; cl17532 515622007830 Bacterial SH3 domain; Region: SH3_3; pfam08239 515622007831 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 515622007832 NlpC/P60 family; Region: NLPC_P60; pfam00877 515622007833 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 515622007834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 515622007835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515622007836 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 515622007837 classical (c) SDRs; Region: SDR_c; cd05233 515622007838 NAD(P) binding site [chemical binding]; other site 515622007839 active site 515622007840 Response regulator receiver domain; Region: Response_reg; pfam00072 515622007841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622007842 active site 515622007843 phosphorylation site [posttranslational modification] 515622007844 intermolecular recognition site; other site 515622007845 dimerization interface [polypeptide binding]; other site 515622007846 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 515622007847 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 515622007848 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 515622007849 active site 515622007850 metal binding site [ion binding]; metal-binding site 515622007851 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 515622007852 CAAX protease self-immunity; Region: Abi; pfam02517 515622007853 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 515622007854 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 515622007855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622007856 Walker A/P-loop; other site 515622007857 ATP binding site [chemical binding]; other site 515622007858 Q-loop/lid; other site 515622007859 ABC transporter signature motif; other site 515622007860 Walker B; other site 515622007861 D-loop; other site 515622007862 H-loop/switch region; other site 515622007863 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 515622007864 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 515622007865 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 515622007866 putative dimer interface [polypeptide binding]; other site 515622007867 catalytic triad [active] 515622007868 Barstar (barnase inhibitor); Region: Barstar; pfam01337 515622007869 RNAase interaction site [polypeptide binding]; other site 515622007870 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 515622007871 active site 515622007872 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 515622007873 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 515622007874 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 515622007875 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 515622007876 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 515622007877 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 515622007878 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 515622007879 PYR/PP interface [polypeptide binding]; other site 515622007880 dimer interface [polypeptide binding]; other site 515622007881 TPP binding site [chemical binding]; other site 515622007882 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 515622007883 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 515622007884 TPP-binding site [chemical binding]; other site 515622007885 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 515622007886 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 515622007887 substrate binding site; other site 515622007888 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 515622007889 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 515622007890 putative NAD(P) binding site [chemical binding]; other site 515622007891 catalytic Zn binding site [ion binding]; other site 515622007892 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 515622007893 substrate binding site; other site 515622007894 dimer interface; other site 515622007895 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 515622007896 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 515622007897 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 515622007898 GDP-Fucose binding site [chemical binding]; other site 515622007899 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 515622007900 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 515622007901 putative glycosyl transferase; Provisional; Region: PRK10073 515622007902 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622007903 active site 515622007904 Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724 515622007905 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622007906 active site 515622007907 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 515622007908 GDP-Fucose binding site [chemical binding]; other site 515622007909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622007910 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 515622007911 Walker A/P-loop; other site 515622007912 ATP binding site [chemical binding]; other site 515622007913 Q-loop/lid; other site 515622007914 ABC transporter signature motif; other site 515622007915 Walker B; other site 515622007916 D-loop; other site 515622007917 H-loop/switch region; other site 515622007918 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 515622007919 GDP-Fucose binding site [chemical binding]; other site 515622007920 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 515622007921 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 515622007922 active site 515622007923 dimer interface [polypeptide binding]; other site 515622007924 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622007925 Ligand Binding Site [chemical binding]; other site 515622007926 Molecular Tunnel; other site 515622007927 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 515622007928 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 515622007929 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622007930 putative ADP-binding pocket [chemical binding]; other site 515622007931 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 515622007932 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 515622007933 active site 515622007934 dimer interface [polypeptide binding]; other site 515622007935 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 515622007936 Ligand Binding Site [chemical binding]; other site 515622007937 Molecular Tunnel; other site 515622007938 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622007939 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 515622007940 putative ADP-binding pocket [chemical binding]; other site 515622007941 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 515622007942 putative ADP-binding pocket [chemical binding]; other site 515622007943 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622007944 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 515622007945 putative ADP-binding pocket [chemical binding]; other site 515622007946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622007947 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u1; cd10925 515622007948 NodB motif; other site 515622007949 putative active site [active] 515622007950 putative catalytic site [active] 515622007951 putative Zn binding site [ion binding]; other site 515622007952 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 515622007953 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 515622007954 NAD binding site [chemical binding]; other site 515622007955 substrate binding site [chemical binding]; other site 515622007956 homodimer interface [polypeptide binding]; other site 515622007957 active site 515622007958 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 515622007959 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 515622007960 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 515622007961 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 515622007962 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622007963 putative ADP-binding pocket [chemical binding]; other site 515622007964 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 515622007965 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 515622007966 D-cysteine desulfhydrase; Validated; Region: PRK03910 515622007967 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 515622007968 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515622007969 catalytic residue [active] 515622007970 Bacterial sugar transferase; Region: Bac_transf; pfam02397 515622007971 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 515622007972 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622007973 inhibitor-cofactor binding pocket; inhibition site 515622007974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622007975 catalytic residue [active] 515622007976 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 515622007977 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 515622007978 NAD(P) binding site [chemical binding]; other site 515622007979 homodimer interface [polypeptide binding]; other site 515622007980 substrate binding site [chemical binding]; other site 515622007981 active site 515622007982 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 515622007983 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 515622007984 Ligand binding site; other site 515622007985 Putative Catalytic site; other site 515622007986 DXD motif; other site 515622007987 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622007988 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622007989 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 515622007990 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515622007991 inhibitor-cofactor binding pocket; inhibition site 515622007992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622007993 catalytic residue [active] 515622007994 Predicted membrane protein [Function unknown]; Region: COG2246 515622007995 GtrA-like protein; Region: GtrA; pfam04138 515622007996 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 515622007997 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622007998 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622007999 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 515622008000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622008001 Walker A/P-loop; other site 515622008002 ATP binding site [chemical binding]; other site 515622008003 Q-loop/lid; other site 515622008004 ABC transporter signature motif; other site 515622008005 Walker B; other site 515622008006 D-loop; other site 515622008007 H-loop/switch region; other site 515622008008 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 515622008009 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622008010 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 515622008011 ligand binding site; other site 515622008012 tetramer interface; other site 515622008013 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622008014 active site 515622008015 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 515622008016 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515622008017 pseudaminic acid synthase; Region: PseI; TIGR03586 515622008018 NeuB family; Region: NeuB; pfam03102 515622008019 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 515622008020 NeuB binding interface [polypeptide binding]; other site 515622008021 putative substrate binding site [chemical binding]; other site 515622008022 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622008023 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 515622008024 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 515622008025 Ligand Binding Site [chemical binding]; other site 515622008026 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515622008027 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622008028 active site 515622008029 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 515622008030 Predicted integral membrane protein [Function unknown]; Region: COG5542 515622008031 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622008032 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622008033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515622008034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515622008035 putative glycosyl transferase; Provisional; Region: PRK10063 515622008036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515622008037 active site 515622008038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622008039 active site 515622008040 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 515622008041 Bacterial sugar transferase; Region: Bac_transf; pfam02397 515622008042 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515622008043 active site 515622008044 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 515622008045 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 515622008046 Ligand binding site; other site 515622008047 Putative Catalytic site; other site 515622008048 DXD motif; other site 515622008049 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 515622008050 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622008051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622008052 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 515622008053 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 515622008054 NADP-binding site; other site 515622008055 homotetramer interface [polypeptide binding]; other site 515622008056 substrate binding site [chemical binding]; other site 515622008057 homodimer interface [polypeptide binding]; other site 515622008058 active site 515622008059 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 515622008060 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 515622008061 NADP binding site [chemical binding]; other site 515622008062 active site 515622008063 putative substrate binding site [chemical binding]; other site 515622008064 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 515622008065 Divergent PAP2 family; Region: DUF212; pfam02681 515622008066 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 515622008067 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 515622008068 NADP binding site [chemical binding]; other site 515622008069 active site 515622008070 putative substrate binding site [chemical binding]; other site 515622008071 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 515622008072 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 515622008073 dimerization domain swap beta strand [polypeptide binding]; other site 515622008074 regulatory protein interface [polypeptide binding]; other site 515622008075 active site 515622008076 regulatory phosphorylation site [posttranslational modification]; other site 515622008077 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 515622008078 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 515622008079 active site 515622008080 substrate binding site [chemical binding]; other site 515622008081 metal binding site [ion binding]; metal-binding site 515622008082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 515622008083 Uncharacterized conserved protein [Function unknown]; Region: COG1624 515622008084 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 515622008085 flagellar operon protein TIGR03826; Region: YvyF 515622008086 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 515622008087 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622008088 active site 515622008089 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 515622008090 AAA domain; Region: AAA_30; pfam13604 515622008091 Family description; Region: UvrD_C_2; pfam13538 515622008092 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 515622008093 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 515622008094 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 515622008095 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 515622008096 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 515622008097 rod shape-determining protein MreB; Provisional; Region: PRK13930 515622008098 MreB and similar proteins; Region: MreB_like; cd10225 515622008099 nucleotide binding site [chemical binding]; other site 515622008100 Mg binding site [ion binding]; other site 515622008101 putative protofilament interaction site [polypeptide binding]; other site 515622008102 RodZ interaction site [polypeptide binding]; other site 515622008103 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 515622008104 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 515622008105 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 515622008106 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 515622008107 excinuclease ABC subunit B; Provisional; Region: PRK05298 515622008108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515622008109 ATP binding site [chemical binding]; other site 515622008110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515622008111 nucleotide binding region [chemical binding]; other site 515622008112 ATP-binding site [chemical binding]; other site 515622008113 Ultra-violet resistance protein B; Region: UvrB; pfam12344 515622008114 UvrB/uvrC motif; Region: UVR; pfam02151 515622008115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 515622008116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 515622008117 active site 515622008118 ATP binding site [chemical binding]; other site 515622008119 substrate binding site [chemical binding]; other site 515622008120 activation loop (A-loop); other site 515622008121 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 515622008122 Protein phosphatase 2C; Region: PP2C; pfam00481 515622008123 active site 515622008124 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 515622008125 C-terminal peptidase (prc); Region: prc; TIGR00225 515622008126 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 515622008127 protein binding site [polypeptide binding]; other site 515622008128 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 515622008129 Catalytic dyad [active] 515622008130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 515622008131 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 515622008132 Peptidase family M23; Region: Peptidase_M23; pfam01551 515622008133 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 515622008134 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 515622008135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622008136 Walker A/P-loop; other site 515622008137 ATP binding site [chemical binding]; other site 515622008138 Q-loop/lid; other site 515622008139 ABC transporter signature motif; other site 515622008140 Walker B; other site 515622008141 D-loop; other site 515622008142 H-loop/switch region; other site 515622008143 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 515622008144 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 515622008145 CAAX protease self-immunity; Region: Abi; pfam02517 515622008146 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 515622008147 S1 domain; Region: S1_2; pfam13509 515622008148 S1 domain; Region: S1_2; pfam13509 515622008149 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 515622008150 RNA binding site [nucleotide binding]; other site 515622008151 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 515622008152 active site 515622008153 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 515622008154 active site 2 [active] 515622008155 active site 1 [active] 515622008156 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 515622008157 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 515622008158 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 515622008159 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 515622008160 Peptidase family U32; Region: Peptidase_U32; pfam01136 515622008161 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 515622008162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008163 S-adenosylmethionine binding site [chemical binding]; other site 515622008164 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 515622008165 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 515622008166 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515622008167 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 515622008168 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 515622008169 hypothetical protein; Provisional; Region: PRK05473 515622008170 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 515622008171 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 515622008172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622008173 FeS/SAM binding site; other site 515622008174 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 515622008175 regulatory protein interface [polypeptide binding]; other site 515622008176 regulatory phosphorylation site [posttranslational modification]; other site 515622008177 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 515622008178 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 515622008179 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 515622008180 Ligand Binding Site [chemical binding]; other site 515622008181 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 515622008182 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 515622008183 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515622008184 catalytic residue [active] 515622008185 RNA methyltransferase, RsmE family; Region: TIGR00046 515622008186 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 515622008187 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 515622008188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008189 S-adenosylmethionine binding site [chemical binding]; other site 515622008190 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 515622008191 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 515622008192 HSP70 interaction site [polypeptide binding]; other site 515622008193 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 515622008194 substrate binding site [polypeptide binding]; other site 515622008195 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 515622008196 Zn binding sites [ion binding]; other site 515622008197 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 515622008198 dimer interface [polypeptide binding]; other site 515622008199 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 515622008200 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 515622008201 nucleotide binding site [chemical binding]; other site 515622008202 GrpE; Region: GrpE; pfam01025 515622008203 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 515622008204 dimer interface [polypeptide binding]; other site 515622008205 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 515622008206 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 515622008207 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 515622008208 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 515622008209 Interdomain contacts; other site 515622008210 Cytokine receptor motif; other site 515622008211 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 515622008212 active site 515622008213 catalytic residues [active] 515622008214 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 515622008215 PA/protease domain interface [polypeptide binding]; other site 515622008216 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 515622008217 putative integrin binding motif; other site 515622008218 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 515622008219 catalytic residues [active] 515622008220 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 515622008221 aspartate aminotransferase; Provisional; Region: PRK06836 515622008222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 515622008223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622008224 homodimer interface [polypeptide binding]; other site 515622008225 catalytic residue [active] 515622008226 urocanate hydratase; Provisional; Region: PRK05414 515622008227 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 515622008228 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 515622008229 G1 box; other site 515622008230 GTP/Mg2+ binding site [chemical binding]; other site 515622008231 Switch I region; other site 515622008232 G2 box; other site 515622008233 G3 box; other site 515622008234 Switch II region; other site 515622008235 G4 box; other site 515622008236 G5 box; other site 515622008237 Nucleoside recognition; Region: Gate; pfam07670 515622008238 Nucleoside recognition; Region: Gate; pfam07670 515622008239 FeoA domain; Region: FeoA; pfam04023 515622008240 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 515622008241 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 515622008242 catalytic residues [active] 515622008243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622008244 Radical SAM superfamily; Region: Radical_SAM; pfam04055 515622008245 FeS/SAM binding site; other site 515622008246 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 515622008247 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 515622008248 active site 515622008249 dimer interface [polypeptide binding]; other site 515622008250 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 515622008251 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 515622008252 FMN binding site [chemical binding]; other site 515622008253 dimer interface [polypeptide binding]; other site 515622008254 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 515622008255 dimer interface [polypeptide binding]; other site 515622008256 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 515622008257 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 515622008258 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 515622008259 putative ATP binding site [chemical binding]; other site 515622008260 putative substrate interface [chemical binding]; other site 515622008261 Uncharacterized conserved protein [Function unknown]; Region: COG1284 515622008262 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 515622008263 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 515622008264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515622008265 NAD(P) binding site [chemical binding]; other site 515622008266 active site 515622008267 6-phosphofructokinase; Provisional; Region: PRK14072 515622008268 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 515622008269 active site 515622008270 ADP/pyrophosphate binding site [chemical binding]; other site 515622008271 dimerization interface [polypeptide binding]; other site 515622008272 allosteric effector site; other site 515622008273 fructose-1,6-bisphosphate binding site; other site 515622008274 Predicted transcriptional regulators [Transcription]; Region: COG1733 515622008275 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 515622008276 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 515622008277 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 515622008278 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 515622008279 CoenzymeA binding site [chemical binding]; other site 515622008280 subunit interaction site [polypeptide binding]; other site 515622008281 PHB binding site; other site 515622008282 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 515622008283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622008284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622008285 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 515622008286 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 515622008287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 515622008288 hypothetical protein; Provisional; Region: PRK11770 515622008289 Domain of unknown function (DUF307); Region: DUF307; pfam03733 515622008290 Domain of unknown function (DUF307); Region: DUF307; pfam03733 515622008291 Uncharacterized conserved protein [Function unknown]; Region: COG1359 515622008292 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 515622008293 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 515622008294 flavodoxin; Provisional; Region: PRK06242 515622008295 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 515622008296 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 515622008297 putative deacylase active site [active] 515622008298 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 515622008299 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622008300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622008301 Coenzyme A binding pocket [chemical binding]; other site 515622008302 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 515622008303 Flavin Reductases; Region: FlaRed; cl00801 515622008304 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 515622008305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 515622008306 putative metal binding site [ion binding]; other site 515622008307 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 515622008308 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 515622008309 active site residue [active] 515622008310 Protein of unknown function (DUF523); Region: DUF523; pfam04463 515622008311 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 515622008312 Beta-lactamase; Region: Beta-lactamase; pfam00144 515622008313 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 515622008314 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622008315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622008316 dimer interface [polypeptide binding]; other site 515622008317 conserved gate region; other site 515622008318 putative PBP binding loops; other site 515622008319 ABC-ATPase subunit interface; other site 515622008320 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515622008321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622008322 dimer interface [polypeptide binding]; other site 515622008323 conserved gate region; other site 515622008324 putative PBP binding loops; other site 515622008325 ABC-ATPase subunit interface; other site 515622008326 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 515622008327 maltodextrin glucosidase; Provisional; Region: PRK10785 515622008328 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 515622008329 homodimer interface [polypeptide binding]; other site 515622008330 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 515622008331 active site 515622008332 homodimer interface [polypeptide binding]; other site 515622008333 catalytic site [active] 515622008334 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622008335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622008336 DNA binding site [nucleotide binding] 515622008337 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 515622008338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622008339 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622008340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622008341 non-specific DNA binding site [nucleotide binding]; other site 515622008342 salt bridge; other site 515622008343 sequence-specific DNA binding site [nucleotide binding]; other site 515622008344 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 515622008345 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 515622008346 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 515622008347 Acyltransferase family; Region: Acyl_transf_3; pfam01757 515622008348 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 515622008349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 515622008350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 515622008351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 515622008352 dimerization interface [polypeptide binding]; other site 515622008353 Ferredoxin [Energy production and conversion]; Region: COG1146 515622008354 4Fe-4S binding domain; Region: Fer4_6; pfam12837 515622008355 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 515622008356 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 515622008357 ligand binding site [chemical binding]; other site 515622008358 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 515622008359 putative switch regulator; other site 515622008360 non-specific DNA interactions [nucleotide binding]; other site 515622008361 DNA binding site [nucleotide binding] 515622008362 sequence specific DNA binding site [nucleotide binding]; other site 515622008363 putative cAMP binding site [chemical binding]; other site 515622008364 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622008365 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622008366 dimer interface [polypeptide binding]; other site 515622008367 putative CheW interface [polypeptide binding]; other site 515622008368 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 515622008369 active site 515622008370 catalytic residues [active] 515622008371 metal binding site [ion binding]; metal-binding site 515622008372 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 515622008373 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 515622008374 active site 515622008375 Predicted membrane protein [Function unknown]; Region: COG2510 515622008376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622008377 AAA domain; Region: AAA_21; pfam13304 515622008378 Walker A/P-loop; other site 515622008379 ATP binding site [chemical binding]; other site 515622008380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622008381 non-specific DNA binding site [nucleotide binding]; other site 515622008382 salt bridge; other site 515622008383 sequence-specific DNA binding site [nucleotide binding]; other site 515622008384 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 515622008385 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 515622008386 HSP70 interaction site [polypeptide binding]; other site 515622008387 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 515622008388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008389 S-adenosylmethionine binding site [chemical binding]; other site 515622008390 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 515622008391 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 515622008392 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 515622008393 nudix motif; other site 515622008394 Protein of unknown function, DUF624; Region: DUF624; cl02369 515622008395 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622008396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622008397 dimer interface [polypeptide binding]; other site 515622008398 conserved gate region; other site 515622008399 putative PBP binding loops; other site 515622008400 ABC-ATPase subunit interface; other site 515622008401 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515622008402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622008403 dimer interface [polypeptide binding]; other site 515622008404 conserved gate region; other site 515622008405 putative PBP binding loops; other site 515622008406 ABC-ATPase subunit interface; other site 515622008407 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622008408 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515622008409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 515622008410 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 515622008411 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622008412 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622008413 DNA binding site [nucleotide binding] 515622008414 domain linker motif; other site 515622008415 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515622008416 dimerization interface [polypeptide binding]; other site 515622008417 ligand binding site [chemical binding]; other site 515622008418 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 515622008419 SWIM zinc finger; Region: SWIM; pfam04434 515622008420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 515622008421 Predicted peptidase [General function prediction only]; Region: COG4099 515622008422 Methyltransferase domain; Region: Methyltransf_31; pfam13847 515622008423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008424 S-adenosylmethionine binding site [chemical binding]; other site 515622008425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622008426 Coenzyme A binding pocket [chemical binding]; other site 515622008427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008428 S-adenosylmethionine binding site [chemical binding]; other site 515622008429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622008430 Coenzyme A binding pocket [chemical binding]; other site 515622008431 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 515622008432 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 515622008433 active site 515622008434 metal binding site [ion binding]; metal-binding site 515622008435 homotetramer interface [polypeptide binding]; other site 515622008436 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 515622008437 active site 1 [active] 515622008438 dimer interface [polypeptide binding]; other site 515622008439 hexamer interface [polypeptide binding]; other site 515622008440 active site 2 [active] 515622008441 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 515622008442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622008443 motif II; other site 515622008444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622008445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622008446 Coenzyme A binding pocket [chemical binding]; other site 515622008447 adenylosuccinate lyase; Provisional; Region: PRK08470 515622008448 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 515622008449 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 515622008450 homotetrameric interface [polypeptide binding]; other site 515622008451 putative active site [active] 515622008452 metal binding site [ion binding]; metal-binding site 515622008453 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622008454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622008455 non-specific DNA binding site [nucleotide binding]; other site 515622008456 salt bridge; other site 515622008457 sequence-specific DNA binding site [nucleotide binding]; other site 515622008458 Domain of unknown function (DUF955); Region: DUF955; cl01076 515622008459 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 515622008460 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 515622008461 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 515622008462 active site 515622008463 Zn binding site [ion binding]; other site 515622008464 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 515622008465 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 515622008466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008467 S-adenosylmethionine binding site [chemical binding]; other site 515622008468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515622008469 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 515622008470 Walker A/P-loop; other site 515622008471 ATP binding site [chemical binding]; other site 515622008472 Q-loop/lid; other site 515622008473 ABC transporter signature motif; other site 515622008474 Walker B; other site 515622008475 D-loop; other site 515622008476 H-loop/switch region; other site 515622008477 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515622008478 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 515622008479 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515622008480 Walker A/P-loop; other site 515622008481 ATP binding site [chemical binding]; other site 515622008482 Q-loop/lid; other site 515622008483 ABC transporter signature motif; other site 515622008484 Walker B; other site 515622008485 D-loop; other site 515622008486 H-loop/switch region; other site 515622008487 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515622008488 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515622008489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622008490 dimer interface [polypeptide binding]; other site 515622008491 conserved gate region; other site 515622008492 putative PBP binding loops; other site 515622008493 ABC-ATPase subunit interface; other site 515622008494 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515622008495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622008496 dimer interface [polypeptide binding]; other site 515622008497 conserved gate region; other site 515622008498 putative PBP binding loops; other site 515622008499 ABC-ATPase subunit interface; other site 515622008500 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 515622008501 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 515622008502 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 515622008503 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 515622008504 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 515622008505 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 515622008506 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 515622008507 catalytic residues [active] 515622008508 catalytic nucleophile [active] 515622008509 Recombinase; Region: Recombinase; pfam07508 515622008510 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 515622008511 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 515622008512 dimer interface [polypeptide binding]; other site 515622008513 putative anticodon binding site; other site 515622008514 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 515622008515 motif 1; other site 515622008516 active site 515622008517 motif 2; other site 515622008518 motif 3; other site 515622008519 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 515622008520 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 515622008521 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 515622008522 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 515622008523 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 515622008524 FMN binding site [chemical binding]; other site 515622008525 active site 515622008526 catalytic residues [active] 515622008527 substrate binding site [chemical binding]; other site 515622008528 pantothenate kinase; Reviewed; Region: PRK13318 515622008529 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 515622008530 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 515622008531 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 515622008532 ornithine carbamoyltransferase; Validated; Region: PRK02102 515622008533 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 515622008534 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 515622008535 Bacterial SH3 domain; Region: SH3_3; cl17532 515622008536 Bacterial SH3 domain; Region: SH3_3; pfam08239 515622008537 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 515622008538 pyrroline-5-carboxylate reductase; Region: PLN02688 515622008539 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 515622008540 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 515622008541 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 515622008542 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 515622008543 6-phosphofructokinase; Provisional; Region: PRK03202 515622008544 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 515622008545 active site 515622008546 ADP/pyrophosphate binding site [chemical binding]; other site 515622008547 dimerization interface [polypeptide binding]; other site 515622008548 allosteric effector site; other site 515622008549 fructose-1,6-bisphosphate binding site; other site 515622008550 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 515622008551 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 515622008552 active site 515622008553 PHP Thumb interface [polypeptide binding]; other site 515622008554 metal binding site [ion binding]; metal-binding site 515622008555 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 515622008556 generic binding surface II; other site 515622008557 generic binding surface I; other site 515622008558 S-adenosylmethionine synthetase; Validated; Region: PRK05250 515622008559 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 515622008560 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 515622008561 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 515622008562 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 515622008563 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 515622008564 putative acyl-acceptor binding pocket; other site 515622008565 Phosphotransferase enzyme family; Region: APH; pfam01636 515622008566 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 515622008567 active site 515622008568 ATP binding site [chemical binding]; other site 515622008569 substrate binding site [chemical binding]; other site 515622008570 Phosphotransferase enzyme family; Region: APH; pfam01636 515622008571 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 515622008572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008573 S-adenosylmethionine binding site [chemical binding]; other site 515622008574 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 515622008575 nudix motif; other site 515622008576 GMP synthase; Reviewed; Region: guaA; PRK00074 515622008577 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 515622008578 AMP/PPi binding site [chemical binding]; other site 515622008579 candidate oxyanion hole; other site 515622008580 catalytic triad [active] 515622008581 potential glutamine specificity residues [chemical binding]; other site 515622008582 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 515622008583 ATP Binding subdomain [chemical binding]; other site 515622008584 Ligand Binding sites [chemical binding]; other site 515622008585 Dimerization subdomain; other site 515622008586 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 515622008587 NlpC/P60 family; Region: NLPC_P60; cl17555 515622008588 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 515622008589 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 515622008590 putative dimer interface [polypeptide binding]; other site 515622008591 putative anticodon binding site; other site 515622008592 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 515622008593 homodimer interface [polypeptide binding]; other site 515622008594 motif 1; other site 515622008595 motif 2; other site 515622008596 active site 515622008597 motif 3; other site 515622008598 trigger factor; Region: tig; TIGR00115 515622008599 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 515622008600 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 515622008601 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 515622008602 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 515622008603 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 515622008604 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 515622008605 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 515622008606 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 515622008607 heterodimer interface [polypeptide binding]; other site 515622008608 active site 515622008609 FMN binding site [chemical binding]; other site 515622008610 homodimer interface [polypeptide binding]; other site 515622008611 substrate binding site [chemical binding]; other site 515622008612 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 515622008613 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 515622008614 FAD binding pocket [chemical binding]; other site 515622008615 FAD binding motif [chemical binding]; other site 515622008616 phosphate binding motif [ion binding]; other site 515622008617 beta-alpha-beta structure motif; other site 515622008618 NAD binding pocket [chemical binding]; other site 515622008619 Iron coordination center [ion binding]; other site 515622008620 dihydroorotase; Validated; Region: pyrC; PRK09357 515622008621 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 515622008622 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 515622008623 active site 515622008624 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 515622008625 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 515622008626 putative acyl-acceptor binding pocket; other site 515622008627 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 515622008628 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 515622008629 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515622008630 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 515622008631 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515622008632 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515622008633 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 515622008634 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 515622008635 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 515622008636 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 515622008637 putative hydratase; Provisional; Region: PRK11413 515622008638 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 515622008639 substrate binding site [chemical binding]; other site 515622008640 ligand binding site [chemical binding]; other site 515622008641 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 515622008642 substrate binding site [chemical binding]; other site 515622008643 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622008644 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 515622008645 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 515622008646 nucleoside/Zn binding site; other site 515622008647 dimer interface [polypeptide binding]; other site 515622008648 catalytic motif [active] 515622008649 Transcriptional regulator; Region: Rrf2; cl17282 515622008650 Rrf2 family protein; Region: rrf2_super; TIGR00738 515622008651 Pleckstrin homology-like domain; Region: PH-like; cl17171 515622008652 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 515622008653 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 515622008654 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 515622008655 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 515622008656 Walker A/P-loop; other site 515622008657 ATP binding site [chemical binding]; other site 515622008658 Q-loop/lid; other site 515622008659 ABC transporter signature motif; other site 515622008660 Walker B; other site 515622008661 D-loop; other site 515622008662 H-loop/switch region; other site 515622008663 TOBE domain; Region: TOBE; pfam03459 515622008664 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622008665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622008666 metal binding site [ion binding]; metal-binding site 515622008667 active site 515622008668 I-site; other site 515622008669 Protein of unknown function, DUF624; Region: DUF624; cl02369 515622008670 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 515622008671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622008672 Coenzyme A binding pocket [chemical binding]; other site 515622008673 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 515622008674 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 515622008675 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 515622008676 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 515622008677 active site 515622008678 HIGH motif; other site 515622008679 KMSKS motif; other site 515622008680 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 515622008681 tRNA binding surface [nucleotide binding]; other site 515622008682 anticodon binding site; other site 515622008683 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 515622008684 dimer interface [polypeptide binding]; other site 515622008685 putative tRNA-binding site [nucleotide binding]; other site 515622008686 methionine aminopeptidase; Provisional; Region: PRK12318 515622008687 SEC-C motif; Region: SEC-C; pfam02810 515622008688 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 515622008689 active site 515622008690 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 515622008691 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 515622008692 active site 515622008693 metal binding site [ion binding]; metal-binding site 515622008694 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 515622008695 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 515622008696 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 515622008697 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 515622008698 substrate binding site [chemical binding]; other site 515622008699 hexamer interface [polypeptide binding]; other site 515622008700 metal binding site [ion binding]; metal-binding site 515622008701 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 515622008702 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 515622008703 PYR/PP interface [polypeptide binding]; other site 515622008704 dimer interface [polypeptide binding]; other site 515622008705 TPP binding site [chemical binding]; other site 515622008706 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515622008707 transketolase; Reviewed; Region: PRK05899 515622008708 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 515622008709 TPP-binding site [chemical binding]; other site 515622008710 dimer interface [polypeptide binding]; other site 515622008711 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 515622008712 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 515622008713 intersubunit interface [polypeptide binding]; other site 515622008714 active site 515622008715 Zn2+ binding site [ion binding]; other site 515622008716 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 515622008717 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 515622008718 putative N- and C-terminal domain interface [polypeptide binding]; other site 515622008719 putative active site [active] 515622008720 MgATP binding site [chemical binding]; other site 515622008721 catalytic site [active] 515622008722 metal binding site [ion binding]; metal-binding site 515622008723 putative carbohydrate binding site [chemical binding]; other site 515622008724 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 515622008725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 515622008726 DNA-binding site [nucleotide binding]; DNA binding site 515622008727 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622008728 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 515622008729 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 515622008730 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 515622008731 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 515622008732 minor groove reading motif; other site 515622008733 helix-hairpin-helix signature motif; other site 515622008734 active site 515622008735 Restriction endonuclease; Region: Mrr_cat; pfam04471 515622008736 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 515622008737 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 515622008738 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 515622008739 Methyltransferase domain; Region: Methyltransf_11; pfam08241 515622008740 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 515622008741 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 515622008742 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 515622008743 DNA binding residues [nucleotide binding] 515622008744 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 515622008745 Methyltransferase domain; Region: Methyltransf_23; pfam13489 515622008746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008747 S-adenosylmethionine binding site [chemical binding]; other site 515622008748 ORF6N domain; Region: ORF6N; pfam10543 515622008749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622008750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622008751 non-specific DNA binding site [nucleotide binding]; other site 515622008752 salt bridge; other site 515622008753 sequence-specific DNA binding site [nucleotide binding]; other site 515622008754 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 515622008755 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 515622008756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008757 S-adenosylmethionine binding site [chemical binding]; other site 515622008758 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 515622008759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622008760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622008761 dimerization interface [polypeptide binding]; other site 515622008762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622008763 dimer interface [polypeptide binding]; other site 515622008764 phosphorylation site [posttranslational modification] 515622008765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622008766 ATP binding site [chemical binding]; other site 515622008767 Mg2+ binding site [ion binding]; other site 515622008768 G-X-G motif; other site 515622008769 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622008770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622008771 active site 515622008772 phosphorylation site [posttranslational modification] 515622008773 intermolecular recognition site; other site 515622008774 dimerization interface [polypeptide binding]; other site 515622008775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622008776 DNA binding site [nucleotide binding] 515622008777 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 515622008778 MutS domain III; Region: MutS_III; pfam05192 515622008779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622008780 Walker A/P-loop; other site 515622008781 ATP binding site [chemical binding]; other site 515622008782 Q-loop/lid; other site 515622008783 ABC transporter signature motif; other site 515622008784 Walker B; other site 515622008785 D-loop; other site 515622008786 H-loop/switch region; other site 515622008787 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 515622008788 Smr domain; Region: Smr; pfam01713 515622008789 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 515622008790 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 515622008791 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 515622008792 protein binding site [polypeptide binding]; other site 515622008793 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 515622008794 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 515622008795 generic binding surface I; other site 515622008796 generic binding surface II; other site 515622008797 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622008798 Zn2+ binding site [ion binding]; other site 515622008799 Mg2+ binding site [ion binding]; other site 515622008800 hypothetical protein; Validated; Region: PRK07682 515622008801 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 515622008802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622008803 homodimer interface [polypeptide binding]; other site 515622008804 catalytic residue [active] 515622008805 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 515622008806 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 515622008807 AsnC family; Region: AsnC_trans_reg; pfam01037 515622008808 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 515622008809 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 515622008810 dimerization interface [polypeptide binding]; other site 515622008811 ATP binding site [chemical binding]; other site 515622008812 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 515622008813 VanW like protein; Region: VanW; pfam04294 515622008814 G5 domain; Region: G5; pfam07501 515622008815 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 515622008816 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 515622008817 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 515622008818 galactokinase; Provisional; Region: PRK05322 515622008819 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 515622008820 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 515622008821 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 515622008822 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 515622008823 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 515622008824 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 515622008825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622008826 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622008827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622008828 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 515622008829 homodimer interface [polypeptide binding]; other site 515622008830 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 515622008831 active site pocket [active] 515622008832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622008833 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622008834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622008835 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 515622008836 Transposase; Region: DEDD_Tnp_IS110; pfam01548 515622008837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 515622008838 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 515622008839 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622008840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622008841 non-specific DNA binding site [nucleotide binding]; other site 515622008842 salt bridge; other site 515622008843 sequence-specific DNA binding site [nucleotide binding]; other site 515622008844 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 515622008845 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 515622008846 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622008847 active site 515622008848 HIGH motif; other site 515622008849 nucleotide binding site [chemical binding]; other site 515622008850 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 515622008851 active site 515622008852 KMSKS motif; other site 515622008853 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 515622008854 tRNA binding surface [nucleotide binding]; other site 515622008855 anticodon binding site; other site 515622008856 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 515622008857 amphipathic channel; other site 515622008858 Asn-Pro-Ala signature motifs; other site 515622008859 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 515622008860 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 515622008861 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 515622008862 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 515622008863 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515622008864 catalytic residue [active] 515622008865 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 515622008866 GAF domain; Region: GAF_2; pfam13185 515622008867 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622008868 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622008869 metal binding site [ion binding]; metal-binding site 515622008870 active site 515622008871 I-site; other site 515622008872 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 515622008873 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 515622008874 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 515622008875 putative RNA binding site [nucleotide binding]; other site 515622008876 Methyltransferase domain; Region: Methyltransf_26; pfam13659 515622008877 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 515622008878 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 515622008879 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 515622008880 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 515622008881 trimer interface [polypeptide binding]; other site 515622008882 active site 515622008883 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 515622008884 catalytic site [active] 515622008885 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 515622008886 CAAX protease self-immunity; Region: Abi; pfam02517 515622008887 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622008888 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622008889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622008890 Walker A/P-loop; other site 515622008891 ATP binding site [chemical binding]; other site 515622008892 Q-loop/lid; other site 515622008893 ABC transporter signature motif; other site 515622008894 Walker B; other site 515622008895 D-loop; other site 515622008896 H-loop/switch region; other site 515622008897 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 515622008898 FtsX-like permease family; Region: FtsX; pfam02687 515622008899 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 515622008900 FtsX-like permease family; Region: FtsX; pfam02687 515622008901 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 515622008902 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 515622008903 Walker A/P-loop; other site 515622008904 ATP binding site [chemical binding]; other site 515622008905 Q-loop/lid; other site 515622008906 ABC transporter signature motif; other site 515622008907 Walker B; other site 515622008908 D-loop; other site 515622008909 H-loop/switch region; other site 515622008910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622008911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622008912 dimer interface [polypeptide binding]; other site 515622008913 phosphorylation site [posttranslational modification] 515622008914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622008915 ATP binding site [chemical binding]; other site 515622008916 Mg2+ binding site [ion binding]; other site 515622008917 G-X-G motif; other site 515622008918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622008919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622008920 active site 515622008921 phosphorylation site [posttranslational modification] 515622008922 intermolecular recognition site; other site 515622008923 dimerization interface [polypeptide binding]; other site 515622008924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622008925 DNA binding site [nucleotide binding] 515622008926 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622008927 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 515622008928 ABC transporter; Region: ABC_tran_2; pfam12848 515622008929 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622008930 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 515622008931 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 515622008932 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 515622008933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 515622008934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622008935 Methyltransferase domain; Region: Methyltransf_31; pfam13847 515622008936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008937 S-adenosylmethionine binding site [chemical binding]; other site 515622008938 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 515622008939 ADP-ribose binding site [chemical binding]; other site 515622008940 dimer interface [polypeptide binding]; other site 515622008941 active site 515622008942 nudix motif; other site 515622008943 metal binding site [ion binding]; metal-binding site 515622008944 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622008945 Zn2+ binding site [ion binding]; other site 515622008946 Mg2+ binding site [ion binding]; other site 515622008947 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 515622008948 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 515622008949 DNA binding residues [nucleotide binding] 515622008950 dimer interface [polypeptide binding]; other site 515622008951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622008952 S-adenosylmethionine binding site [chemical binding]; other site 515622008953 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622008954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622008955 non-specific DNA binding site [nucleotide binding]; other site 515622008956 salt bridge; other site 515622008957 sequence-specific DNA binding site [nucleotide binding]; other site 515622008958 Abi-like protein; Region: Abi_2; pfam07751 515622008959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622008960 Coenzyme A binding pocket [chemical binding]; other site 515622008961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515622008962 dimerization interface [polypeptide binding]; other site 515622008963 putative DNA binding site [nucleotide binding]; other site 515622008964 putative Zn2+ binding site [ion binding]; other site 515622008965 Transcriptional regulator; Region: Transcrip_reg; cl00361 515622008966 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622008967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622008968 non-specific DNA binding site [nucleotide binding]; other site 515622008969 salt bridge; other site 515622008970 sequence-specific DNA binding site [nucleotide binding]; other site 515622008971 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622008972 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622008973 non-specific DNA binding site [nucleotide binding]; other site 515622008974 salt bridge; other site 515622008975 sequence-specific DNA binding site [nucleotide binding]; other site 515622008976 Melibiase; Region: Melibiase; pfam02065 515622008977 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622008978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622008979 metal binding site [ion binding]; metal-binding site 515622008980 active site 515622008981 I-site; other site 515622008982 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 515622008983 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 515622008984 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 515622008985 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 515622008986 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 515622008987 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 515622008988 Walker A/P-loop; other site 515622008989 ATP binding site [chemical binding]; other site 515622008990 Q-loop/lid; other site 515622008991 ABC transporter signature motif; other site 515622008992 Walker B; other site 515622008993 D-loop; other site 515622008994 H-loop/switch region; other site 515622008995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622008996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622008997 ATP binding site [chemical binding]; other site 515622008998 Mg2+ binding site [ion binding]; other site 515622008999 G-X-G motif; other site 515622009000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515622009001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622009002 active site 515622009003 phosphorylation site [posttranslational modification] 515622009004 intermolecular recognition site; other site 515622009005 dimerization interface [polypeptide binding]; other site 515622009006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515622009007 DNA binding site [nucleotide binding] 515622009008 Erythromycin esterase; Region: Erythro_esteras; pfam05139 515622009009 LytTr DNA-binding domain; Region: LytTR; pfam04397 515622009010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 515622009011 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622009012 Coenzyme A binding pocket [chemical binding]; other site 515622009013 stage V sporulation protein K; Region: spore_V_K; TIGR02881 515622009014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622009015 Walker A motif; other site 515622009016 ATP binding site [chemical binding]; other site 515622009017 Walker B motif; other site 515622009018 arginine finger; other site 515622009019 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 515622009020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515622009021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622009022 dimerization interface [polypeptide binding]; other site 515622009023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622009024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622009025 dimer interface [polypeptide binding]; other site 515622009026 phosphorylation site [posttranslational modification] 515622009027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622009028 ATP binding site [chemical binding]; other site 515622009029 Mg2+ binding site [ion binding]; other site 515622009030 G-X-G motif; other site 515622009031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622009032 Response regulator receiver domain; Region: Response_reg; pfam00072 515622009033 active site 515622009034 phosphorylation site [posttranslational modification] 515622009035 intermolecular recognition site; other site 515622009036 dimerization interface [polypeptide binding]; other site 515622009037 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515622009038 Flavin Reductases; Region: FlaRed; cl00801 515622009039 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 515622009040 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 515622009041 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 515622009042 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 515622009043 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 515622009044 intersubunit interface [polypeptide binding]; other site 515622009045 active site 515622009046 zinc binding site [ion binding]; other site 515622009047 Na+ binding site [ion binding]; other site 515622009048 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 515622009049 homodimer interface [polypeptide binding]; other site 515622009050 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 515622009051 active site 515622009052 homodimer interface [polypeptide binding]; other site 515622009053 catalytic site [active] 515622009054 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 515622009055 FtsH Extracellular; Region: FtsH_ext; pfam06480 515622009056 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 515622009057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622009058 Walker A motif; other site 515622009059 ATP binding site [chemical binding]; other site 515622009060 Walker B motif; other site 515622009061 arginine finger; other site 515622009062 Peptidase family M41; Region: Peptidase_M41; pfam01434 515622009063 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622009064 active site 515622009065 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 515622009066 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 515622009067 Ligand Binding Site [chemical binding]; other site 515622009068 TilS substrate C-terminal domain; Region: TilS_C; smart00977 515622009069 Septum formation initiator; Region: DivIC; cl17659 515622009070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515622009071 RNA binding surface [nucleotide binding]; other site 515622009072 PEGA domain; Region: PEGA; pfam08308 515622009073 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 515622009074 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 515622009075 active site 515622009076 NTP binding site [chemical binding]; other site 515622009077 metal binding triad [ion binding]; metal-binding site 515622009078 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 515622009079 HD domain; Region: HD; pfam01966 515622009080 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 515622009081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622009082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622009083 metal binding site [ion binding]; metal-binding site 515622009084 active site 515622009085 I-site; other site 515622009086 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622009087 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622009088 metal binding site [ion binding]; metal-binding site 515622009089 active site 515622009090 I-site; other site 515622009091 prolyl-tRNA synthetase; Provisional; Region: PRK08661 515622009092 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 515622009093 dimer interface [polypeptide binding]; other site 515622009094 motif 1; other site 515622009095 active site 515622009096 motif 2; other site 515622009097 motif 3; other site 515622009098 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 515622009099 anticodon binding site; other site 515622009100 zinc-binding site [ion binding]; other site 515622009101 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 515622009102 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 515622009103 substrate binding site [chemical binding]; other site 515622009104 ATP binding site [chemical binding]; other site 515622009105 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 515622009106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622009107 FeS/SAM binding site; other site 515622009108 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 515622009109 ATP cone domain; Region: ATP-cone; pfam03477 515622009110 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 515622009111 glutamate racemase; Provisional; Region: PRK00865 515622009112 Bacterial SH3 domain; Region: SH3_3; pfam08239 515622009113 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 515622009114 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 515622009115 catalytic residues [active] 515622009116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622009117 S-adenosylmethionine binding site [chemical binding]; other site 515622009118 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 515622009119 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 515622009120 exonuclease; Provisional; Region: PRK06722 515622009121 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 515622009122 active site 515622009123 catalytic site [active] 515622009124 substrate binding site [chemical binding]; other site 515622009125 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 515622009126 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 515622009127 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 515622009128 catalytic residues [active] 515622009129 dimer interface [polypeptide binding]; other site 515622009130 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 515622009131 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 515622009132 NADH(P)-binding; Region: NAD_binding_10; pfam13460 515622009133 NAD(P) binding site [chemical binding]; other site 515622009134 putative active site [active] 515622009135 Flavin Reductases; Region: FlaRed; cl00801 515622009136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622009137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622009138 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 515622009139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515622009140 RNA binding surface [nucleotide binding]; other site 515622009141 Clostripain family; Region: Peptidase_C11; pfam03415 515622009142 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 515622009143 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 515622009144 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 515622009145 active site 515622009146 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 515622009147 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622009148 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622009149 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 515622009150 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515622009151 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515622009152 DNA binding site [nucleotide binding] 515622009153 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622009154 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 515622009155 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 515622009156 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 515622009157 active site 515622009158 catalytic tetrad [active] 515622009159 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 515622009160 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 515622009161 active site 515622009162 catalytic triad [active] 515622009163 oxyanion hole [active] 515622009164 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 515622009165 active site 515622009166 dimer interfaces [polypeptide binding]; other site 515622009167 catalytic residues [active] 515622009168 Protein of unknown function (DUF456); Region: DUF456; cl01069 515622009169 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515622009170 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 515622009171 anti sigma factor interaction site; other site 515622009172 regulatory phosphorylation site [posttranslational modification]; other site 515622009173 Archaeal ATPase; Region: Arch_ATPase; pfam01637 515622009174 AAA ATPase domain; Region: AAA_16; pfam13191 515622009175 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 515622009176 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 515622009177 catalytic core [active] 515622009178 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 515622009179 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 515622009180 seryl-tRNA synthetase; Provisional; Region: PRK05431 515622009181 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 515622009182 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 515622009183 motif 1; other site 515622009184 dimer interface [polypeptide binding]; other site 515622009185 active site 515622009186 motif 2; other site 515622009187 motif 3; other site 515622009188 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 515622009189 ParB-like nuclease domain; Region: ParB; smart00470 515622009190 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 515622009191 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515622009192 P-loop; other site 515622009193 Magnesium ion binding site [ion binding]; other site 515622009194 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515622009195 Magnesium ion binding site [ion binding]; other site 515622009196 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 515622009197 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 515622009198 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 515622009199 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 515622009200 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 515622009201 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 515622009202 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 515622009203 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 515622009204 trmE is a tRNA modification GTPase; Region: trmE; cd04164 515622009205 G1 box; other site 515622009206 GTP/Mg2+ binding site [chemical binding]; other site 515622009207 Switch I region; other site 515622009208 G2 box; other site 515622009209 Switch II region; other site 515622009210 G3 box; other site 515622009211 G4 box; other site 515622009212 G5 box; other site 515622009213 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 515622009214 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 515622009215 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 515622009216 G-X-X-G motif; other site 515622009217 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 515622009218 RxxxH motif; other site 515622009219 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 515622009220 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 515622009221 Haemolytic domain; Region: Haemolytic; pfam01809 515622009222 ribonuclease P; Reviewed; Region: rnpA; PRK00499 515622009223 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 515622009224 Initiator Replication protein; Region: Rep_3; pfam01051 515622009225 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 515622009226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622009227 Walker A motif; other site 515622009228 ATP binding site [chemical binding]; other site 515622009229 Walker B motif; other site 515622009230 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 515622009231 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 515622009232 HypF finger; Region: zf-HYPF; pfam07503 515622009233 Protein of unknown function DUF111; Region: DUF111; pfam01969 515622009234 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515622009235 PAS domain S-box; Region: sensory_box; TIGR00229 515622009236 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622009237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622009238 metal binding site [ion binding]; metal-binding site 515622009239 active site 515622009240 I-site; other site 515622009241 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622009242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622009243 metal binding site [ion binding]; metal-binding site 515622009244 active site 515622009245 I-site; other site 515622009246 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622009247 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 515622009248 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 515622009249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 515622009250 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 515622009251 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 515622009252 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 515622009253 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 515622009254 active site 515622009255 catalytic site [active] 515622009256 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 515622009257 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 515622009258 PHP domain; Region: PHP; pfam02811 515622009259 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 515622009260 active site 515622009261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622009262 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622009263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622009264 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 515622009265 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515622009266 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515622009267 nucleotide binding site [chemical binding]; other site 515622009268 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 515622009269 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 515622009270 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 515622009271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515622009272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622009273 dimer interface [polypeptide binding]; other site 515622009274 conserved gate region; other site 515622009275 putative PBP binding loops; other site 515622009276 ABC-ATPase subunit interface; other site 515622009277 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 515622009278 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 515622009279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622009280 dimer interface [polypeptide binding]; other site 515622009281 conserved gate region; other site 515622009282 putative PBP binding loops; other site 515622009283 ABC-ATPase subunit interface; other site 515622009284 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515622009285 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515622009286 Walker A/P-loop; other site 515622009287 ATP binding site [chemical binding]; other site 515622009288 Q-loop/lid; other site 515622009289 ABC transporter signature motif; other site 515622009290 Walker B; other site 515622009291 D-loop; other site 515622009292 H-loop/switch region; other site 515622009293 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 515622009294 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 515622009295 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515622009296 Walker A/P-loop; other site 515622009297 ATP binding site [chemical binding]; other site 515622009298 Q-loop/lid; other site 515622009299 ABC transporter signature motif; other site 515622009300 Walker B; other site 515622009301 D-loop; other site 515622009302 H-loop/switch region; other site 515622009303 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 515622009304 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 515622009305 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 515622009306 active site 515622009307 trimer interface [polypeptide binding]; other site 515622009308 allosteric site; other site 515622009309 active site lid [active] 515622009310 hexamer (dimer of trimers) interface [polypeptide binding]; other site 515622009311 Beta-lactamase; Region: Beta-lactamase; cl17358 515622009312 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 515622009313 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 515622009314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622009315 FeS/SAM binding site; other site 515622009316 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 515622009317 ATP cone domain; Region: ATP-cone; pfam03477 515622009318 Class III ribonucleotide reductase; Region: RNR_III; cd01675 515622009319 effector binding site; other site 515622009320 active site 515622009321 Zn binding site [ion binding]; other site 515622009322 glycine loop; other site 515622009323 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 515622009324 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 515622009325 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 515622009326 trimer interface [polypeptide binding]; other site 515622009327 putative metal binding site [ion binding]; other site 515622009328 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826 515622009329 Cl binding site [ion binding]; other site 515622009330 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 515622009331 oligomer interface [polypeptide binding]; other site 515622009332 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 515622009333 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 515622009334 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515622009335 active site 515622009336 nucleotide binding site [chemical binding]; other site 515622009337 HIGH motif; other site 515622009338 KMSKS motif; other site 515622009339 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 515622009340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622009341 Walker A/P-loop; other site 515622009342 ATP binding site [chemical binding]; other site 515622009343 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 515622009344 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 515622009345 MoxR-like ATPases [General function prediction only]; Region: COG0714 515622009346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622009347 Walker A motif; other site 515622009348 ATP binding site [chemical binding]; other site 515622009349 Walker B motif; other site 515622009350 arginine finger; other site 515622009351 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 515622009352 Protein of unknown function DUF58; Region: DUF58; pfam01882 515622009353 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 515622009354 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 515622009355 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 515622009356 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 515622009357 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 515622009358 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 515622009359 Walker A/P-loop; other site 515622009360 ATP binding site [chemical binding]; other site 515622009361 Q-loop/lid; other site 515622009362 ABC transporter signature motif; other site 515622009363 Walker B; other site 515622009364 D-loop; other site 515622009365 H-loop/switch region; other site 515622009366 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 515622009367 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 515622009368 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 515622009369 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622009370 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 515622009371 dimerization interface [polypeptide binding]; other site 515622009372 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515622009373 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 515622009374 dimer interface [polypeptide binding]; other site 515622009375 putative CheW interface [polypeptide binding]; other site 515622009376 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 515622009377 putative homodimer interface [polypeptide binding]; other site 515622009378 putative homotetramer interface [polypeptide binding]; other site 515622009379 putative allosteric switch controlling residues; other site 515622009380 putative metal binding site [ion binding]; other site 515622009381 putative homodimer-homodimer interface [polypeptide binding]; other site 515622009382 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 515622009383 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 515622009384 metal-binding site [ion binding] 515622009385 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 515622009386 Soluble P-type ATPase [General function prediction only]; Region: COG4087 515622009387 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 515622009388 metal-binding site [ion binding] 515622009389 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 515622009390 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 515622009391 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 515622009392 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 515622009393 active site 515622009394 metal binding site [ion binding]; metal-binding site 515622009395 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 515622009396 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 515622009397 Rhomboid family; Region: Rhomboid; pfam01694 515622009398 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 515622009399 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 515622009400 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 515622009401 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622009402 ABC transporter; Region: ABC_tran_2; pfam12848 515622009403 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 515622009404 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 515622009405 Part of AAA domain; Region: AAA_19; pfam13245 515622009406 Family description; Region: UvrD_C_2; pfam13538 515622009407 FMN-binding domain; Region: FMN_bind; pfam04205 515622009408 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 515622009409 L-aspartate oxidase; Provisional; Region: PRK06175 515622009410 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622009411 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622009412 metal binding site [ion binding]; metal-binding site 515622009413 active site 515622009414 I-site; other site 515622009415 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 515622009416 Melibiase; Region: Melibiase; pfam02065 515622009417 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 515622009418 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 515622009419 ADP-ribose binding site [chemical binding]; other site 515622009420 inner membrane transporter YjeM; Provisional; Region: PRK15238 515622009421 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 515622009422 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 515622009423 EamA-like transporter family; Region: EamA; pfam00892 515622009424 EamA-like transporter family; Region: EamA; pfam00892 515622009425 Probable transposase; Region: OrfB_IS605; pfam01385 515622009426 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 515622009427 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 515622009428 Protein of unknown function (DUF998); Region: DUF998; pfam06197 515622009429 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 515622009430 conserved cys residue [active] 515622009431 CAAX protease self-immunity; Region: Abi; pfam02517 515622009432 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 515622009433 Transposase IS200 like; Region: Y1_Tnp; pfam01797 515622009434 CAAX protease self-immunity; Region: Abi; pfam02517 515622009435 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 515622009436 nudix motif; other site 515622009437 hypothetical protein; Provisional; Region: PRK09273 515622009438 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 515622009439 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 515622009440 Transposase; Region: DEDD_Tnp_IS110; pfam01548 515622009441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 515622009442 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 515622009443 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 515622009444 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 515622009445 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622009446 DNA binding site [nucleotide binding] 515622009447 WYL domain; Region: WYL; pfam13280 515622009448 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 515622009449 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 515622009450 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 515622009451 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 515622009452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622009453 Walker A motif; other site 515622009454 ATP binding site [chemical binding]; other site 515622009455 Walker B motif; other site 515622009456 arginine finger; other site 515622009457 Peptidase family M41; Region: Peptidase_M41; pfam01434 515622009458 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 515622009459 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 515622009460 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 515622009461 WYL domain; Region: WYL; pfam13280 515622009462 stage V sporulation protein K; Region: spore_V_K; TIGR02881 515622009463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622009464 Walker A motif; other site 515622009465 ATP binding site [chemical binding]; other site 515622009466 Walker B motif; other site 515622009467 arginine finger; other site 515622009468 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 515622009469 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622009470 Walker A motif; other site 515622009471 ATP binding site [chemical binding]; other site 515622009472 Walker B motif; other site 515622009473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622009474 Response regulator receiver domain; Region: Response_reg; pfam00072 515622009475 active site 515622009476 phosphorylation site [posttranslational modification] 515622009477 intermolecular recognition site; other site 515622009478 dimerization interface [polypeptide binding]; other site 515622009479 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 515622009480 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 515622009481 active site 515622009482 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 515622009483 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 515622009484 putative active site [active] 515622009485 putative NTP binding site [chemical binding]; other site 515622009486 putative nucleic acid binding site [nucleotide binding]; other site 515622009487 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 515622009488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 515622009489 Integrase core domain; Region: rve; pfam00665 515622009490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 515622009491 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622009492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622009493 non-specific DNA binding site [nucleotide binding]; other site 515622009494 salt bridge; other site 515622009495 sequence-specific DNA binding site [nucleotide binding]; other site 515622009496 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 515622009497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 515622009498 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622009499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622009500 Coenzyme A binding pocket [chemical binding]; other site 515622009501 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 515622009502 AAA domain; Region: AAA_14; pfam13173 515622009503 Probable transposase; Region: OrfB_IS605; pfam01385 515622009504 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 515622009505 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 515622009506 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 515622009507 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 515622009508 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 515622009509 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 515622009510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515622009511 motif II; other site 515622009512 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 515622009513 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 515622009514 putative NADP binding site [chemical binding]; other site 515622009515 putative substrate binding site [chemical binding]; other site 515622009516 active site 515622009517 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 515622009518 HicB family; Region: HicB; pfam05534 515622009519 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622009520 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622009521 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 515622009522 active site 515622009523 Ap4A binding cleft/pocket [chemical binding]; other site 515622009524 P4 phosphate binding site; other site 515622009525 nudix motif; other site 515622009526 putative P2/P3 phosphate binding site [ion binding]; other site 515622009527 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 515622009528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515622009529 putative substrate translocation pore; other site 515622009530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515622009531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622009532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622009533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622009534 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 515622009535 FeS/SAM binding site; other site 515622009536 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 515622009537 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515622009538 substrate binding pocket [chemical binding]; other site 515622009539 membrane-bound complex binding site; other site 515622009540 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622009541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622009542 metal binding site [ion binding]; metal-binding site 515622009543 active site 515622009544 I-site; other site 515622009545 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622009546 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 515622009547 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622009548 active site 515622009549 DNA binding site [nucleotide binding] 515622009550 Int/Topo IB signature motif; other site 515622009551 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 515622009552 CoenzymeA binding site [chemical binding]; other site 515622009553 subunit interaction site [polypeptide binding]; other site 515622009554 PHB binding site; other site 515622009555 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 515622009556 nudix motif; other site 515622009557 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 515622009558 Clostripain family; Region: Peptidase_C11; pfam03415 515622009559 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 515622009560 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 515622009561 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 515622009562 Walker A/P-loop; other site 515622009563 ATP binding site [chemical binding]; other site 515622009564 Q-loop/lid; other site 515622009565 ABC transporter signature motif; other site 515622009566 Walker B; other site 515622009567 D-loop; other site 515622009568 H-loop/switch region; other site 515622009569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515622009570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515622009571 N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749 515622009572 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 515622009573 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 515622009574 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 515622009575 dimer interface [polypeptide binding]; other site 515622009576 active site 515622009577 metal binding site [ion binding]; metal-binding site 515622009578 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 515622009579 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 515622009580 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 515622009581 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622009582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622009583 Walker A/P-loop; other site 515622009584 ATP binding site [chemical binding]; other site 515622009585 Q-loop/lid; other site 515622009586 ABC transporter signature motif; other site 515622009587 Walker B; other site 515622009588 D-loop; other site 515622009589 H-loop/switch region; other site 515622009590 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515622009591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515622009592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515622009593 Walker A/P-loop; other site 515622009594 ATP binding site [chemical binding]; other site 515622009595 Q-loop/lid; other site 515622009596 ABC transporter signature motif; other site 515622009597 Walker B; other site 515622009598 D-loop; other site 515622009599 H-loop/switch region; other site 515622009600 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 515622009601 carbohydrate binding site [chemical binding]; other site 515622009602 pullulanase, type I; Region: pulA_typeI; TIGR02104 515622009603 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 515622009604 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 515622009605 Ca binding site [ion binding]; other site 515622009606 active site 515622009607 catalytic site [active] 515622009608 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 515622009609 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 515622009610 active site 515622009611 DNA binding site [nucleotide binding] 515622009612 putative catalytic site [active] 515622009613 AP binding site [nucleotide binding]; other site 515622009614 putative phosphate binding site [ion binding]; other site 515622009615 metal binding site B [ion binding]; metal-binding site 515622009616 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 515622009617 catalytic core [active] 515622009618 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622009619 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 515622009620 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 515622009621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622009622 Coenzyme A binding pocket [chemical binding]; other site 515622009623 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 515622009624 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515622009625 dimerization interface [polypeptide binding]; other site 515622009626 putative Zn2+ binding site [ion binding]; other site 515622009627 putative DNA binding site [nucleotide binding]; other site 515622009628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622009629 non-specific DNA binding site [nucleotide binding]; other site 515622009630 salt bridge; other site 515622009631 sequence-specific DNA binding site [nucleotide binding]; other site 515622009632 Cupin domain; Region: Cupin_2; pfam07883 515622009633 Transcriptional regulator; Region: Rrf2; cl17282 515622009634 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622009635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622009636 Radical SAM superfamily; Region: Radical_SAM; pfam04055 515622009637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622009638 FeS/SAM binding site; other site 515622009639 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 515622009640 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 515622009641 MarR family; Region: MarR; pfam01047 515622009642 Cupin domain; Region: Cupin_2; pfam07883 515622009643 Predicted transcriptional regulators [Transcription]; Region: COG1733 515622009644 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 515622009645 Beta-lactamase; Region: Beta-lactamase; pfam00144 515622009646 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 515622009647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515622009648 Coenzyme A binding pocket [chemical binding]; other site 515622009649 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 515622009650 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 515622009651 DNA binding residues [nucleotide binding] 515622009652 dimer interface [polypeptide binding]; other site 515622009653 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 515622009654 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 515622009655 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 515622009656 putative active site [active] 515622009657 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 515622009658 active site 515622009659 homodimer interface [polypeptide binding]; other site 515622009660 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 515622009661 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 515622009662 putative sugar binding sites [chemical binding]; other site 515622009663 Q-X-W motif; other site 515622009664 Right handed beta helix region; Region: Beta_helix; pfam13229 515622009665 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515622009666 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622009667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515622009668 S-adenosylmethionine binding site [chemical binding]; other site 515622009669 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 515622009670 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 515622009671 G1 box; other site 515622009672 GTP/Mg2+ binding site [chemical binding]; other site 515622009673 Switch I region; other site 515622009674 G2 box; other site 515622009675 G3 box; other site 515622009676 Switch II region; other site 515622009677 G4 box; other site 515622009678 G5 box; other site 515622009679 Nucleoside recognition; Region: Gate; pfam07670 515622009680 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 515622009681 Nucleoside recognition; Region: Gate; pfam07670 515622009682 FeoA domain; Region: FeoA; cl00838 515622009683 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 515622009684 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 515622009685 putative active site [active] 515622009686 putative catalytic site [active] 515622009687 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515622009688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622009689 dimer interface [polypeptide binding]; other site 515622009690 conserved gate region; other site 515622009691 putative PBP binding loops; other site 515622009692 ABC-ATPase subunit interface; other site 515622009693 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 515622009694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622009695 dimer interface [polypeptide binding]; other site 515622009696 conserved gate region; other site 515622009697 putative PBP binding loops; other site 515622009698 ABC-ATPase subunit interface; other site 515622009699 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515622009700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622009701 Response regulator receiver domain; Region: Response_reg; pfam00072 515622009702 active site 515622009703 phosphorylation site [posttranslational modification] 515622009704 intermolecular recognition site; other site 515622009705 dimerization interface [polypeptide binding]; other site 515622009706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622009707 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622009708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622009709 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622009710 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515622009711 dimerization interface [polypeptide binding]; other site 515622009712 Histidine kinase; Region: His_kinase; pfam06580 515622009713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622009714 ATP binding site [chemical binding]; other site 515622009715 Mg2+ binding site [ion binding]; other site 515622009716 G-X-G motif; other site 515622009717 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 515622009718 G1 box; other site 515622009719 GTP/Mg2+ binding site [chemical binding]; other site 515622009720 G2 box; other site 515622009721 Switch I region; other site 515622009722 G3 box; other site 515622009723 Switch II region; other site 515622009724 G4 box; other site 515622009725 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 515622009726 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 515622009727 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622009728 active site 515622009729 DNA binding site [nucleotide binding] 515622009730 Int/Topo IB signature motif; other site 515622009731 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515622009732 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 515622009733 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515622009734 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515622009735 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515622009736 zinc-finger; Region: zf-RING_3; pfam14369 515622009737 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622009738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622009739 metal binding site [ion binding]; metal-binding site 515622009740 active site 515622009741 I-site; other site 515622009742 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 515622009743 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 515622009744 ligand binding site [chemical binding]; other site 515622009745 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 515622009746 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515622009747 P-loop; other site 515622009748 Magnesium ion binding site [ion binding]; other site 515622009749 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515622009750 Magnesium ion binding site [ion binding]; other site 515622009751 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 515622009752 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 515622009753 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 515622009754 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515622009755 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515622009756 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515622009757 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 515622009758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622009759 ATP binding site [chemical binding]; other site 515622009760 Mg2+ binding site [ion binding]; other site 515622009761 G-X-G motif; other site 515622009762 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 515622009763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622009764 active site 515622009765 phosphorylation site [posttranslational modification] 515622009766 intermolecular recognition site; other site 515622009767 dimerization interface [polypeptide binding]; other site 515622009768 LytTr DNA-binding domain; Region: LytTR; smart00850 515622009769 BioY family; Region: BioY; pfam02632 515622009770 Biotin operon repressor [Transcription]; Region: BirA; COG1654 515622009771 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 515622009772 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 515622009773 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 515622009774 Walker A/P-loop; other site 515622009775 ATP binding site [chemical binding]; other site 515622009776 Q-loop/lid; other site 515622009777 ABC transporter signature motif; other site 515622009778 Walker B; other site 515622009779 D-loop; other site 515622009780 H-loop/switch region; other site 515622009781 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 515622009782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515622009783 dimer interface [polypeptide binding]; other site 515622009784 conserved gate region; other site 515622009785 putative PBP binding loops; other site 515622009786 ABC-ATPase subunit interface; other site 515622009787 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 515622009788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515622009789 substrate binding pocket [chemical binding]; other site 515622009790 membrane-bound complex binding site; other site 515622009791 hinge residues; other site 515622009792 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 515622009793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 515622009794 DNA-binding site [nucleotide binding]; DNA binding site 515622009795 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 515622009796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515622009797 homodimer interface [polypeptide binding]; other site 515622009798 catalytic residue [active] 515622009799 radical SAM enzyme, rSAM/lipoprotein system; Region: rSAM_w_lipo; TIGR04133 515622009800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622009801 FeS/SAM binding site; other site 515622009802 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 515622009803 Predicted membrane protein [Function unknown]; Region: COG4905 515622009804 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 515622009805 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 515622009806 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 515622009807 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515622009808 active site 515622009809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 515622009810 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 515622009811 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515622009812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622009813 salt bridge; other site 515622009814 non-specific DNA binding site [nucleotide binding]; other site 515622009815 sequence-specific DNA binding site [nucleotide binding]; other site 515622009816 Response regulator receiver domain; Region: Response_reg; pfam00072 515622009817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622009818 active site 515622009819 phosphorylation site [posttranslational modification] 515622009820 intermolecular recognition site; other site 515622009821 dimerization interface [polypeptide binding]; other site 515622009822 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622009823 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 515622009824 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622009825 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515622009826 TM-ABC transporter signature motif; other site 515622009827 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 515622009828 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515622009829 TM-ABC transporter signature motif; other site 515622009830 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 515622009831 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515622009832 Walker A/P-loop; other site 515622009833 ATP binding site [chemical binding]; other site 515622009834 Q-loop/lid; other site 515622009835 ABC transporter signature motif; other site 515622009836 Walker B; other site 515622009837 D-loop; other site 515622009838 H-loop/switch region; other site 515622009839 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515622009840 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 515622009841 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622009842 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 515622009843 Histidine kinase; Region: His_kinase; pfam06580 515622009844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622009845 ATP binding site [chemical binding]; other site 515622009846 Mg2+ binding site [ion binding]; other site 515622009847 G-X-G motif; other site 515622009848 Response regulator receiver domain; Region: Response_reg; pfam00072 515622009849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622009850 active site 515622009851 phosphorylation site [posttranslational modification] 515622009852 intermolecular recognition site; other site 515622009853 dimerization interface [polypeptide binding]; other site 515622009854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622009855 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515622009856 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515622009857 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 515622009858 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 515622009859 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 515622009860 active site 515622009861 catalytic site [active] 515622009862 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 515622009863 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 515622009864 putative ligand binding site [chemical binding]; other site 515622009865 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515622009866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622009867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622009868 metal binding site [ion binding]; metal-binding site 515622009869 active site 515622009870 I-site; other site 515622009871 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 515622009872 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 515622009873 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515622009874 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 515622009875 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 515622009876 IHF dimer interface [polypeptide binding]; other site 515622009877 IHF - DNA interface [nucleotide binding]; other site 515622009878 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 515622009879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515622009880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515622009881 dimer interface [polypeptide binding]; other site 515622009882 phosphorylation site [posttranslational modification] 515622009883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515622009884 ATP binding site [chemical binding]; other site 515622009885 Mg2+ binding site [ion binding]; other site 515622009886 G-X-G motif; other site 515622009887 Response regulator receiver domain; Region: Response_reg; pfam00072 515622009888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515622009889 active site 515622009890 phosphorylation site [posttranslational modification] 515622009891 intermolecular recognition site; other site 515622009892 dimerization interface [polypeptide binding]; other site 515622009893 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 515622009894 putative binding surface; other site 515622009895 active site 515622009896 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 515622009897 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515622009898 P-loop; other site 515622009899 Magnesium ion binding site [ion binding]; other site 515622009900 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515622009901 Magnesium ion binding site [ion binding]; other site 515622009902 Initiator Replication protein; Region: Rep_3; pfam01051 515622009903 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 515622009904 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622009905 active site 515622009906 DNA binding site [nucleotide binding] 515622009907 Int/Topo IB signature motif; other site 515622009908 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622009909 Walker A motif; other site 515622009910 PIN domain; Region: PIN; pfam01850 515622009911 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 515622009912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622009913 Walker A motif; other site 515622009914 ATP binding site [chemical binding]; other site 515622009915 Walker B motif; other site 515622009916 arginine finger; other site 515622009917 Peptidase family M41; Region: Peptidase_M41; pfam01434 515622009918 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 515622009919 ADP-ribose binding site [chemical binding]; other site 515622009920 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 515622009921 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 515622009922 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 515622009923 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 515622009924 RNA/DNA hybrid binding site [nucleotide binding]; other site 515622009925 active site 515622009926 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 515622009927 Coenzyme A binding pocket [chemical binding]; other site 515622009928 AAA domain; Region: AAA_22; pfam13401 515622009929 AAA domain; Region: AAA_30; pfam13604 515622009930 Family description; Region: UvrD_C_2; pfam13538 515622009931 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 515622009932 Predicted transcriptional regulator [Transcription]; Region: COG2944 515622009933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622009934 non-specific DNA binding site [nucleotide binding]; other site 515622009935 salt bridge; other site 515622009936 sequence-specific DNA binding site [nucleotide binding]; other site 515622009937 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 515622009938 Divergent AAA domain; Region: AAA_4; pfam04326 515622009939 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 515622009940 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515622009941 putative DNA binding site [nucleotide binding]; other site 515622009942 putative Zn2+ binding site [ion binding]; other site 515622009943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622009944 active site 515622009945 DNA binding site [nucleotide binding] 515622009946 Int/Topo IB signature motif; other site 515622009947 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 515622009948 TIGR02452 family protein; Region: TIGR02452 515622009949 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 515622009950 DEAD-box ATP-dependent RNA helicase; Provisional; Region: PLN00206 515622009951 DNA topoisomerase I; Validated; Region: PRK07219 515622009952 Smr domain; Region: Smr; cl02619 515622009953 SprT homologues; Region: SprT; cl01182 515622009954 Transposase domain (DUF772); Region: DUF772; pfam05598 515622009955 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 515622009956 Transposase domain (DUF772); Region: DUF772; pfam05598 515622009957 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 515622009958 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 515622009959 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 515622009960 Probable transposase; Region: OrfB_IS605; pfam01385 515622009961 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 515622009962 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 515622009963 DNA methylase; Region: N6_N4_Mtase; pfam01555 515622009964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622009965 non-specific DNA binding site [nucleotide binding]; other site 515622009966 salt bridge; other site 515622009967 sequence-specific DNA binding site [nucleotide binding]; other site 515622009968 AAA domain; Region: AAA_13; pfam13166 515622009969 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 515622009970 putative active site [active] 515622009971 Probable transposase; Region: OrfB_IS605; pfam01385 515622009972 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 515622009973 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 515622009974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622009975 non-specific DNA binding site [nucleotide binding]; other site 515622009976 salt bridge; other site 515622009977 sequence-specific DNA binding site [nucleotide binding]; other site 515622009978 Transposase IS200 like; Region: Y1_Tnp; pfam01797 515622009979 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 515622009980 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 515622009981 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 515622009982 nucleotide binding pocket [chemical binding]; other site 515622009983 K-X-D-G motif; other site 515622009984 catalytic site [active] 515622009985 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 515622009986 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 515622009987 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 515622009988 Dimer interface [polypeptide binding]; other site 515622009989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 515622009990 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 515622009991 Probable transposase; Region: OrfB_IS605; pfam01385 515622009992 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 515622009993 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 515622009994 Protein of unknown function (DUF497); Region: DUF497; cl01108 515622009995 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 515622009996 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 515622009997 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 515622009998 active site 515622009999 metal binding site [ion binding]; metal-binding site 515622010000 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 515622010001 AAA domain; Region: AAA_23; pfam13476 515622010002 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 515622010003 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 515622010004 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 515622010005 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 515622010006 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 515622010007 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 515622010008 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 515622010009 Ligand Binding Site [chemical binding]; other site 515622010010 Resolvase, N terminal domain; Region: Resolvase; smart00857 515622010011 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 515622010012 catalytic residues [active] 515622010013 multiple promoter invertase; Provisional; Region: mpi; PRK13413 515622010014 Resolvase, N terminal domain; Region: Resolvase; pfam00239 515622010015 catalytic residues [active] 515622010016 catalytic nucleophile [active] 515622010017 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 515622010018 linker region; other site 515622010019 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 515622010020 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 515622010021 catalytic residues [active] 515622010022 catalytic nucleophile [active] 515622010023 Presynaptic Site I dimer interface [polypeptide binding]; other site 515622010024 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 515622010025 Synaptic Flat tetramer interface [polypeptide binding]; other site 515622010026 Synaptic Site I dimer interface [polypeptide binding]; other site 515622010027 DNA binding site [nucleotide binding] 515622010028 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 515622010029 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 515622010030 linker region; other site 515622010031 Sec1 family; Region: Sec1; cl15415 515622010032 PcfJ-like protein; Region: PcfJ; pfam14284 515622010033 LabA_like proteins; Region: LabA_like/DUF88; cl10034 515622010034 putative metal binding site [ion binding]; other site 515622010035 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 515622010036 IHF dimer interface [polypeptide binding]; other site 515622010037 IHF - DNA interface [nucleotide binding]; other site 515622010038 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 515622010039 Part of AAA domain; Region: AAA_19; pfam13245 515622010040 Family description; Region: UvrD_C_2; pfam13538 515622010041 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283 515622010042 nad+ binding pocket [chemical binding]; other site 515622010043 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 515622010044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515622010045 Zn2+ binding site [ion binding]; other site 515622010046 Mg2+ binding site [ion binding]; other site 515622010047 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 515622010048 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 515622010049 active site 515622010050 catalytic site [active] 515622010051 substrate binding site [chemical binding]; other site 515622010052 Transglutaminase/protease-like homologues; Region: TGc; smart00460 515622010053 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 515622010054 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 515622010055 Catalytic site [active] 515622010056 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 515622010057 generic binding surface II; other site 515622010058 generic binding surface I; other site 515622010059 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 515622010060 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 515622010061 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 515622010062 generic binding surface I; other site 515622010063 generic binding surface II; other site 515622010064 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 515622010065 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 515622010066 active site 515622010067 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 515622010068 AAA-like domain; Region: AAA_10; pfam12846 515622010069 Domain of unknown function DUF87; Region: DUF87; pfam01935 515622010070 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622010071 Walker A motif; other site 515622010072 ATP binding site [chemical binding]; other site 515622010073 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 515622010074 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 515622010075 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 515622010076 DNA-binding site [nucleotide binding]; DNA binding site 515622010077 RNA-binding motif; other site 515622010078 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 515622010079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 515622010080 This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins; Region: SAF; smart00858 515622010081 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 515622010082 NlpC/P60 family; Region: NLPC_P60; cl17555 515622010083 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 515622010084 Staphylococcal nuclease homologues; Region: SNc; smart00318 515622010085 Catalytic site; other site 515622010086 Staphylococcal nuclease homologue; Region: SNase; pfam00565 515622010087 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 515622010088 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 515622010089 ligand binding site [chemical binding]; other site 515622010090 active site 515622010091 UGI interface [polypeptide binding]; other site 515622010092 catalytic site [active] 515622010093 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 515622010094 Mg binding site [ion binding]; other site 515622010095 nucleotide binding site [chemical binding]; other site 515622010096 putative protofilament interface [polypeptide binding]; other site 515622010097 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 515622010098 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622010099 Walker A motif; other site 515622010100 ATP binding site [chemical binding]; other site 515622010101 Walker B motif; other site 515622010102 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 515622010103 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 515622010104 active site 515622010105 metal binding site [ion binding]; metal-binding site 515622010106 DNA topoisomerase III; Provisional; Region: PRK07726 515622010107 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 515622010108 active site 515622010109 putative interdomain interaction site [polypeptide binding]; other site 515622010110 putative metal-binding site [ion binding]; other site 515622010111 putative nucleotide binding site [chemical binding]; other site 515622010112 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 515622010113 domain I; other site 515622010114 DNA binding groove [nucleotide binding] 515622010115 phosphate binding site [ion binding]; other site 515622010116 domain II; other site 515622010117 domain III; other site 515622010118 nucleotide binding site [chemical binding]; other site 515622010119 catalytic site [active] 515622010120 domain IV; other site 515622010121 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 515622010122 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 515622010123 DHH family; Region: DHH; pfam01368 515622010124 DHHA1 domain; Region: DHHA1; pfam02272 515622010125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622010126 non-specific DNA binding site [nucleotide binding]; other site 515622010127 salt bridge; other site 515622010128 sequence-specific DNA binding site [nucleotide binding]; other site 515622010129 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 515622010130 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 515622010131 Catalytic site [active] 515622010132 phosphodiesterase; Provisional; Region: PRK12704 515622010133 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 515622010134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515622010135 ATP binding site [chemical binding]; other site 515622010136 putative Mg++ binding site [ion binding]; other site 515622010137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515622010138 nucleotide binding region [chemical binding]; other site 515622010139 ATP-binding site [chemical binding]; other site 515622010140 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 515622010141 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 515622010142 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 515622010143 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 515622010144 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 515622010145 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 515622010146 domain interaction interfaces [polypeptide binding]; other site 515622010147 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 515622010148 domain interaction interfaces [polypeptide binding]; other site 515622010149 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 515622010150 domain interaction interfaces [polypeptide binding]; other site 515622010151 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 515622010152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 515622010153 DNA binding residues [nucleotide binding] 515622010154 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 515622010155 AAA domain; Region: AAA_30; pfam13604 515622010156 Family description; Region: UvrD_C_2; pfam13538 515622010157 Zeta toxin; Region: Zeta_toxin; pfam06414 515622010158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 515622010159 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 515622010160 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 515622010161 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515622010162 metal binding site [ion binding]; metal-binding site 515622010163 active site 515622010164 I-site; other site 515622010165 Sm and related proteins; Region: Sm_like; cl00259 515622010166 Sm1 motif; other site 515622010167 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 515622010168 Part of AAA domain; Region: AAA_19; pfam13245 515622010169 Family description; Region: UvrD_C_2; pfam13538 515622010170 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 515622010171 Protein of unknown function, DUF600; Region: DUF600; cl04640 515622010172 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 515622010173 CHC2 zinc finger; Region: zf-CHC2; cl17510 515622010174 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 515622010175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 515622010176 Probable transposase; Region: OrfB_IS605; pfam01385 515622010177 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 515622010178 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 515622010179 active site 515622010180 catalytic site [active] 515622010181 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622010182 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 515622010183 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 515622010184 active site 515622010185 catalytic site [active] 515622010186 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 515622010187 Cna protein B-type domain; Region: Cna_B; pfam05738 515622010188 Cna protein B-type domain; Region: Cna_B; pfam05738 515622010189 Cna protein B-type domain; Region: Cna_B; pfam05738 515622010190 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 515622010191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 515622010192 Probable transposase; Region: OrfB_IS605; pfam01385 515622010193 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 515622010194 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 515622010195 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 515622010196 active site 515622010197 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 515622010198 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 515622010199 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 515622010200 Pleckstrin homology-like domain; Region: PH-like; cl17171 515622010201 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 515622010202 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 515622010203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515622010204 putative Mg++ binding site [ion binding]; other site 515622010205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 515622010206 Probable transposase; Region: OrfB_IS605; pfam01385 515622010207 Transposase IS200 like; Region: Y1_Tnp; pfam01797 515622010208 CRISPR-associated protein Cpf1, subtype PREFRAN; Region: cas_Cpf1; TIGR04330 515622010209 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 515622010210 CAAX protease self-immunity; Region: Abi; pfam02517 515622010211 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 515622010212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515622010213 FeS/SAM binding site; other site 515622010214 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 515622010215 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 515622010216 dimer interface [polypeptide binding]; other site 515622010217 ssDNA binding site [nucleotide binding]; other site 515622010218 tetramer (dimer of dimers) interface [polypeptide binding]; other site 515622010219 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 515622010220 ATP cone domain; Region: ATP-cone; pfam03477 515622010221 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 515622010222 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 515622010223 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 515622010224 active site 515622010225 catalytic triad [active] 515622010226 oxyanion hole [active] 515622010227 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 515622010228 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515622010229 P-loop; other site 515622010230 Magnesium ion binding site [ion binding]; other site 515622010231 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515622010232 Magnesium ion binding site [ion binding]; other site 515622010233 Initiator Replication protein; Region: Rep_3; pfam01051 515622010234 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 515622010235 Mg binding site [ion binding]; other site 515622010236 nucleotide binding site [chemical binding]; other site 515622010237 putative protofilament interface [polypeptide binding]; other site 515622010238 putative active site [active] 515622010239 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 515622010240 AAA-like domain; Region: AAA_10; pfam12846 515622010241 Transposase; Region: DEDD_Tnp_IS110; pfam01548 515622010242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 515622010243 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 515622010244 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 515622010245 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622010246 Walker A motif; other site 515622010247 ATP binding site [chemical binding]; other site 515622010248 Walker B motif; other site 515622010249 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 515622010250 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 515622010251 active site 515622010252 TDP-binding site; other site 515622010253 acceptor substrate-binding pocket; other site 515622010254 homodimer interface [polypeptide binding]; other site 515622010255 Protein of unknown function (DUF493); Region: DUF493; cl01102 515622010256 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 515622010257 SEFIR domain; Region: SEFIR; pfam08357 515622010258 NlpC/P60 family; Region: NLPC_P60; cl17555 515622010259 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 515622010260 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 515622010261 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 515622010262 RNA binding site [nucleotide binding]; other site 515622010263 This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins; Region: SAF; smart00858 515622010264 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 515622010265 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515622010266 Walker A motif; other site 515622010267 ATP binding site [chemical binding]; other site 515622010268 Walker B motif; other site 515622010269 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 515622010270 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 515622010271 dimer interface [polypeptide binding]; other site 515622010272 ssDNA binding site [nucleotide binding]; other site 515622010273 tetramer (dimer of dimers) interface [polypeptide binding]; other site 515622010274 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 515622010275 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 515622010276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515622010277 ATP binding site [chemical binding]; other site 515622010278 putative Mg++ binding site [ion binding]; other site 515622010279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515622010280 nucleotide binding region [chemical binding]; other site 515622010281 ATP-binding site [chemical binding]; other site 515622010282 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 515622010283 active site 515622010284 catalytic triad [active] 515622010285 oxyanion hole [active] 515622010286 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 515622010287 IHF - DNA interface [nucleotide binding]; other site 515622010288 IHF dimer interface [polypeptide binding]; other site 515622010289 ORF6N domain; Region: ORF6N; pfam10543 515622010290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622010291 non-specific DNA binding site [nucleotide binding]; other site 515622010292 salt bridge; other site 515622010293 sequence-specific DNA binding site [nucleotide binding]; other site 515622010294 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 515622010295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622010296 Walker A motif; other site 515622010297 ATP binding site [chemical binding]; other site 515622010298 Walker B motif; other site 515622010299 arginine finger; other site 515622010300 RelB antitoxin; Region: RelB; cl01171 515622010301 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 515622010302 Restriction endonuclease; Region: Mrr_cat; pfam04471 515622010303 Uncharacterized conserved protein [Function unknown]; Region: COG4127 515622010304 Restriction endonuclease; Region: Mrr_cat; pfam04471 515622010305 HsdM N-terminal domain; Region: HsdM_N; pfam12161 515622010306 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 515622010307 Methyltransferase domain; Region: Methyltransf_26; pfam13659 515622010308 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 515622010309 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 515622010310 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 515622010311 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 515622010312 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 515622010313 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 515622010314 Restriction endonuclease; Region: Mrr_cat; pfam04471 515622010315 Restriction endonuclease; Region: Mrr_cat; pfam04471 515622010316 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 515622010317 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 515622010318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515622010319 ATP binding site [chemical binding]; other site 515622010320 putative Mg++ binding site [ion binding]; other site 515622010321 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 515622010322 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 515622010323 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 515622010324 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 515622010325 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515622010326 active site 515622010327 DNA binding site [nucleotide binding] 515622010328 Int/Topo IB signature motif; other site 515622010329 SWIM zinc finger; Region: SWIM; pfam04434 515622010330 Caspase domain; Region: Peptidase_C14; pfam00656 515622010331 substrate pocket [chemical binding]; other site 515622010332 active site 515622010333 proteolytic cleavage site; other site 515622010334 dimer interface [polypeptide binding]; other site 515622010335 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 515622010336 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 515622010337 DNA-binding site [nucleotide binding]; DNA binding site 515622010338 RNA-binding motif; other site 515622010339 HTH domain; Region: HTH_11; pfam08279 515622010340 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 515622010341 Protein kinase domain; Region: Pkinase; pfam00069 515622010342 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 515622010343 active site 515622010344 ATP binding site [chemical binding]; other site 515622010345 substrate binding site [chemical binding]; other site 515622010346 activation loop (A-loop); other site 515622010347 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 515622010348 Initiator Replication protein; Region: Rep_3; pfam01051 515622010349 DNA replication protein DnaC; Validated; Region: PRK06835 515622010350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622010351 Walker A motif; other site 515622010352 ATP binding site [chemical binding]; other site 515622010353 Walker B motif; other site 515622010354 arginine finger; other site 515622010355 replicative DNA helicase; Region: DnaB; TIGR00665 515622010356 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 515622010357 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 515622010358 Walker A motif; other site 515622010359 ATP binding site [chemical binding]; other site 515622010360 Walker B motif; other site 515622010361 DNA binding loops [nucleotide binding] 515622010362 DNA polymerase III PolC; Validated; Region: polC; PRK00448 515622010363 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 515622010364 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 515622010365 generic binding surface II; other site 515622010366 generic binding surface I; other site 515622010367 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 515622010368 active site 515622010369 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 515622010370 active site 515622010371 catalytic site [active] 515622010372 substrate binding site [chemical binding]; other site 515622010373 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 515622010374 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 515622010375 active site 515622010376 catalytic triad [active] 515622010377 oxyanion hole [active] 515622010378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622010379 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 515622010380 Walker A motif; other site 515622010381 ATP binding site [chemical binding]; other site 515622010382 Walker B motif; other site 515622010383 arginine finger; other site 515622010384 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 515622010385 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 515622010386 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 515622010387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622010388 Walker A motif; other site 515622010389 ATP binding site [chemical binding]; other site 515622010390 Walker B motif; other site 515622010391 arginine finger; other site 515622010392 Peptidase family M41; Region: Peptidase_M41; pfam01434 515622010393 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 515622010394 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 515622010395 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 515622010396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622010397 Walker A motif; other site 515622010398 ATP binding site [chemical binding]; other site 515622010399 Walker B motif; other site 515622010400 arginine finger; other site 515622010401 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 515622010402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515622010403 WYL domain; Region: WYL; pfam13280 515622010404 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 515622010405 DnaA box-binding interface [nucleotide binding]; other site 515622010406 Initiator Replication protein; Region: Rep_3; pfam01051 515622010407 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 515622010408 WYL domain; Region: WYL; pfam13280 515622010409 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 515622010410 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 515622010411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515622010412 Walker A motif; other site 515622010413 ATP binding site [chemical binding]; other site 515622010414 Walker B motif; other site 515622010415 arginine finger; other site 515622010416 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 515622010417 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 515622010418 Mor transcription activator family; Region: Mor; cl02360 515622010419 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 515622010420 DNA polymerase IV; Reviewed; Region: PRK03103 515622010421 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 515622010422 active site 515622010423 DNA binding site [nucleotide binding] 515622010424 YolD-like protein; Region: YolD; pfam08863 515622010425 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 515622010426 Helix-turn-helix domain; Region: HTH_17; pfam12728 515622010427 Isochorismatase family; Region: Isochorismatase; pfam00857 515622010428 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 515622010429 catalytic triad [active] 515622010430 conserved cis-peptide bond; other site 515622010431 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 515622010432 Coenzyme A binding pocket [chemical binding]; other site 515622010433 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 515622010434 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 515622010435 CHC2 zinc finger; Region: zf-CHC2; cl17510 515622010436 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 515622010437 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 515622010438 AAA domain; Region: AAA_30; pfam13604 515622010439 Family description; Region: UvrD_C_2; pfam13538 515622010440 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 515622010441 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 515622010442 Catalytic site [active] 515622010443 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 515622010444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515622010445 non-specific DNA binding site [nucleotide binding]; other site 515622010446 salt bridge; other site 515622010447 sequence-specific DNA binding site [nucleotide binding]; other site 515622010448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 515622010449 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 515622010450 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 515622010451 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515622010452 P-loop; other site 515622010453 Magnesium ion binding site [ion binding]; other site 515622010454 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515622010455 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 515622010456 ParB-like nuclease domain; Region: ParB; smart00470