-- dump date   	20140619_020259
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
632292000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
632292000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
632292000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292000004	Walker A motif; other site
632292000005	ATP binding site [chemical binding]; other site
632292000006	Walker B motif; other site
632292000007	arginine finger; other site
632292000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
632292000009	DnaA box-binding interface [nucleotide binding]; other site
632292000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
632292000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
632292000012	putative DNA binding surface [nucleotide binding]; other site
632292000013	dimer interface [polypeptide binding]; other site
632292000014	beta-clamp/clamp loader binding surface; other site
632292000015	beta-clamp/translesion DNA polymerase binding surface; other site
632292000016	recombination protein F; Reviewed; Region: recF; PRK00064
632292000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292000018	Walker A/P-loop; other site
632292000019	ATP binding site [chemical binding]; other site
632292000020	Q-loop/lid; other site
632292000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292000022	ABC transporter signature motif; other site
632292000023	Walker B; other site
632292000024	D-loop; other site
632292000025	H-loop/switch region; other site
632292000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
632292000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000028	ATP binding site [chemical binding]; other site
632292000029	Mg2+ binding site [ion binding]; other site
632292000030	G-X-G motif; other site
632292000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
632292000032	anchoring element; other site
632292000033	dimer interface [polypeptide binding]; other site
632292000034	ATP binding site [chemical binding]; other site
632292000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
632292000036	active site
632292000037	putative metal-binding site [ion binding]; other site
632292000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
632292000039	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
632292000040	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
632292000041	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632292000042	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
632292000043	DNA gyrase subunit A; Validated; Region: PRK05560
632292000044	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
632292000045	CAP-like domain; other site
632292000046	active site
632292000047	primary dimer interface [polypeptide binding]; other site
632292000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632292000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632292000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632292000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632292000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632292000053	Beta propeller domain; Region: Beta_propel; pfam09826
632292000054	Transposase domain (DUF772); Region: DUF772; pfam05598
632292000055	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
632292000056	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
632292000057	peroxiredoxin; Provisional; Region: PRK13189
632292000058	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
632292000059	dimer interface [polypeptide binding]; other site
632292000060	decamer (pentamer of dimers) interface [polypeptide binding]; other site
632292000061	catalytic triad [active]
632292000062	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632292000063	putative active site [active]
632292000064	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
632292000065	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
632292000066	putative active site [active]
632292000067	Methyltransferase domain; Region: Methyltransf_23; pfam13489
632292000068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292000069	S-adenosylmethionine binding site [chemical binding]; other site
632292000070	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205
632292000071	PLD-like domain; Region: PLDc_2; pfam13091
632292000072	putative homodimer interface [polypeptide binding]; other site
632292000073	putative active site [active]
632292000074	catalytic site [active]
632292000075	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
632292000076	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292000077	ATP binding site [chemical binding]; other site
632292000078	putative Mg++ binding site [ion binding]; other site
632292000079	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632292000080	nucleotide binding region [chemical binding]; other site
632292000081	ATP-binding site [chemical binding]; other site
632292000082	KWG Leptospira; Region: KWG; pfam07656
632292000083	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632292000084	Probable transposase; Region: OrfB_IS605; pfam01385
632292000085	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632292000086	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632292000087	putative active site [active]
632292000088	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
632292000089	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
632292000090	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
632292000091	GDP-binding site [chemical binding]; other site
632292000092	ACT binding site; other site
632292000093	IMP binding site; other site
632292000094	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632292000095	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292000096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292000097	Walker A/P-loop; other site
632292000098	ATP binding site [chemical binding]; other site
632292000099	Q-loop/lid; other site
632292000100	ABC transporter signature motif; other site
632292000101	Walker B; other site
632292000102	D-loop; other site
632292000103	H-loop/switch region; other site
632292000104	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632292000105	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292000106	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
632292000107	Walker A/P-loop; other site
632292000108	ATP binding site [chemical binding]; other site
632292000109	Q-loop/lid; other site
632292000110	ABC transporter signature motif; other site
632292000111	Walker B; other site
632292000112	D-loop; other site
632292000113	H-loop/switch region; other site
632292000114	Integral membrane protein DUF95; Region: DUF95; pfam01944
632292000115	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
632292000116	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
632292000117	O-Antigen ligase; Region: Wzy_C; pfam04932
632292000118	O-Antigen ligase; Region: Wzy_C; cl04850
632292000119	TPR repeat; Region: TPR_11; pfam13414
632292000120	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
632292000121	binding surface
632292000122	TPR motif; other site
632292000123	Tetratricopeptide repeat; Region: TPR_12; pfam13424
632292000124	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
632292000125	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292000126	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292000127	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
632292000128	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
632292000129	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292000130	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292000131	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
632292000132	putative ADP-binding pocket [chemical binding]; other site
632292000133	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
632292000134	putative metal binding site; other site
632292000135	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
632292000136	Bacterial sugar transferase; Region: Bac_transf; pfam02397
632292000137	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
632292000138	ADP-ribose binding site [chemical binding]; other site
632292000139	dimer interface [polypeptide binding]; other site
632292000140	active site
632292000141	nudix motif; other site
632292000142	metal binding site [ion binding]; metal-binding site
632292000143	Transposase domain (DUF772); Region: DUF772; pfam05598
632292000144	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
632292000145	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
632292000146	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
632292000147	Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907
632292000148	ADP-ribose binding site [chemical binding]; other site
632292000149	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292000150	S-layer homology domain; Region: SLH; pfam00395
632292000151	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
632292000152	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
632292000153	CTP synthetase; Validated; Region: pyrG; PRK05380
632292000154	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
632292000155	Catalytic site [active]
632292000156	active site
632292000157	UTP binding site [chemical binding]; other site
632292000158	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
632292000159	active site
632292000160	putative oxyanion hole; other site
632292000161	catalytic triad [active]
632292000162	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632292000163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000164	active site
632292000165	phosphorylation site [posttranslational modification]
632292000166	intermolecular recognition site; other site
632292000167	dimerization interface [polypeptide binding]; other site
632292000168	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632292000169	DNA binding site [nucleotide binding]
632292000170	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
632292000171	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292000172	dimerization interface [polypeptide binding]; other site
632292000173	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
632292000174	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632292000175	dimer interface [polypeptide binding]; other site
632292000176	phosphorylation site [posttranslational modification]
632292000177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000178	ATP binding site [chemical binding]; other site
632292000179	Mg2+ binding site [ion binding]; other site
632292000180	G-X-G motif; other site
632292000181	Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ValS; COG0525
632292000182	YycH protein; Region: YycH; pfam07435
632292000183	YycH protein; Region: YycI; cl02015
632292000184	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292000185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000186	dimer interface [polypeptide binding]; other site
632292000187	conserved gate region; other site
632292000188	putative PBP binding loops; other site
632292000189	ABC-ATPase subunit interface; other site
632292000190	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000192	dimer interface [polypeptide binding]; other site
632292000193	conserved gate region; other site
632292000194	putative PBP binding loops; other site
632292000195	ABC-ATPase subunit interface; other site
632292000196	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000197	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292000198	dimerization interface [polypeptide binding]; other site
632292000199	Histidine kinase; Region: His_kinase; pfam06580
632292000200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000201	ATP binding site [chemical binding]; other site
632292000202	Mg2+ binding site [ion binding]; other site
632292000203	G-X-G motif; other site
632292000204	Response regulator receiver domain; Region: Response_reg; pfam00072
632292000205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000206	active site
632292000207	phosphorylation site [posttranslational modification]
632292000208	intermolecular recognition site; other site
632292000209	dimerization interface [polypeptide binding]; other site
632292000210	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000211	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292000212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000213	S-layer homology domain; Region: SLH; pfam00395
632292000214	S-layer homology domain; Region: SLH; pfam00395
632292000215	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
632292000216	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
632292000217	active site
632292000218	catalytic residues [active]
632292000219	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632292000220	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632292000221	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
632292000222	putative metal binding site [ion binding]; other site
632292000223	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632292000224	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632292000225	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632292000226	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292000227	dimerization interface [polypeptide binding]; other site
632292000228	Histidine kinase; Region: His_kinase; pfam06580
632292000229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000230	ATP binding site [chemical binding]; other site
632292000231	Mg2+ binding site [ion binding]; other site
632292000232	G-X-G motif; other site
632292000233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000234	active site
632292000235	phosphorylation site [posttranslational modification]
632292000236	intermolecular recognition site; other site
632292000237	dimerization interface [polypeptide binding]; other site
632292000238	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000239	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292000240	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000241	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000242	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000243	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000244	dimer interface [polypeptide binding]; other site
632292000245	conserved gate region; other site
632292000246	putative PBP binding loops; other site
632292000247	ABC-ATPase subunit interface; other site
632292000248	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000250	dimer interface [polypeptide binding]; other site
632292000251	conserved gate region; other site
632292000252	putative PBP binding loops; other site
632292000253	ABC-ATPase subunit interface; other site
632292000254	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000255	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
632292000256	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
632292000257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000258	dimer interface [polypeptide binding]; other site
632292000259	conserved gate region; other site
632292000260	putative PBP binding loops; other site
632292000261	ABC-ATPase subunit interface; other site
632292000262	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000264	dimer interface [polypeptide binding]; other site
632292000265	conserved gate region; other site
632292000266	putative PBP binding loops; other site
632292000267	ABC-ATPase subunit interface; other site
632292000268	maltose phosphorylase; Provisional; Region: PRK13807
632292000269	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
632292000270	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
632292000271	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
632292000272	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
632292000273	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
632292000274	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
632292000275	beta-phosphoglucomutase; Region: bPGM; TIGR01990
632292000276	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
632292000277	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292000278	motif II; other site
632292000279	S-layer homology domain; Region: SLH; pfam00395
632292000280	S-layer homology domain; Region: SLH; pfam00395
632292000281	S-layer homology domain; Region: SLH; pfam00395
632292000282	CARDB; Region: CARDB; pfam07705
632292000283	CARDB; Region: CARDB; pfam07705
632292000284	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619
632292000285	putative ligand binding site [chemical binding]; other site
632292000286	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
632292000287	putative metal binding site [ion binding]; other site
632292000288	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
632292000289	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
632292000290	Right handed beta helix region; Region: Beta_helix; pfam13229
632292000291	Right handed beta helix region; Region: Beta_helix; pfam13229
632292000292	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
632292000293	Histidine kinase; Region: His_kinase; pfam06580
632292000294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000295	ATP binding site [chemical binding]; other site
632292000296	Mg2+ binding site [ion binding]; other site
632292000297	G-X-G motif; other site
632292000298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000299	Response regulator receiver domain; Region: Response_reg; pfam00072
632292000300	active site
632292000301	phosphorylation site [posttranslational modification]
632292000302	intermolecular recognition site; other site
632292000303	dimerization interface [polypeptide binding]; other site
632292000304	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000305	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292000306	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000307	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000308	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000310	dimer interface [polypeptide binding]; other site
632292000311	conserved gate region; other site
632292000312	putative PBP binding loops; other site
632292000313	ABC-ATPase subunit interface; other site
632292000314	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000316	dimer interface [polypeptide binding]; other site
632292000317	conserved gate region; other site
632292000318	putative PBP binding loops; other site
632292000319	ABC-ATPase subunit interface; other site
632292000320	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
632292000321	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
632292000322	dimer interface [polypeptide binding]; other site
632292000323	active site
632292000324	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
632292000325	dimer interface [polypeptide binding]; other site
632292000326	active site
632292000327	Response regulator receiver domain; Region: Response_reg; pfam00072
632292000328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000329	active site
632292000330	phosphorylation site [posttranslational modification]
632292000331	intermolecular recognition site; other site
632292000332	dimerization interface [polypeptide binding]; other site
632292000333	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292000334	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000335	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292000336	dimerization interface [polypeptide binding]; other site
632292000337	Histidine kinase; Region: His_kinase; pfam06580
632292000338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000339	ATP binding site [chemical binding]; other site
632292000340	Mg2+ binding site [ion binding]; other site
632292000341	G-X-G motif; other site
632292000342	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
632292000343	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
632292000344	active site
632292000345	substrate binding site [chemical binding]; other site
632292000346	metal binding site [ion binding]; metal-binding site
632292000347	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
632292000348	catalytic domain interface [polypeptide binding]; other site
632292000349	putative homodimer interface [polypeptide binding]; other site
632292000350	Protein of unknown function, DUF608; Region: DUF608; pfam04685
632292000351	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632292000352	Coenzyme A binding pocket [chemical binding]; other site
632292000353	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
632292000354	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
632292000355	putative active site [active]
632292000356	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
632292000357	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
632292000358	active site
632292000359	dimer interface [polypeptide binding]; other site
632292000360	Response regulator receiver domain; Region: Response_reg; pfam00072
632292000361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000362	active site
632292000363	phosphorylation site [posttranslational modification]
632292000364	intermolecular recognition site; other site
632292000365	dimerization interface [polypeptide binding]; other site
632292000366	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000367	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292000368	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000369	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
632292000370	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292000371	dimerization interface [polypeptide binding]; other site
632292000372	Histidine kinase; Region: His_kinase; pfam06580
632292000373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000374	ATP binding site [chemical binding]; other site
632292000375	Mg2+ binding site [ion binding]; other site
632292000376	G-X-G motif; other site
632292000377	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000378	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000379	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
632292000380	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000381	dimer interface [polypeptide binding]; other site
632292000382	conserved gate region; other site
632292000383	putative PBP binding loops; other site
632292000384	ABC-ATPase subunit interface; other site
632292000385	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000387	dimer interface [polypeptide binding]; other site
632292000388	conserved gate region; other site
632292000389	putative PBP binding loops; other site
632292000390	ABC-ATPase subunit interface; other site
632292000391	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
632292000392	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
632292000393	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292000394	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000395	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000396	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000397	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292000398	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000399	ABC-ATPase subunit interface; other site
632292000400	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000402	dimer interface [polypeptide binding]; other site
632292000403	conserved gate region; other site
632292000404	putative PBP binding loops; other site
632292000405	ABC-ATPase subunit interface; other site
632292000406	beta-D-glucuronidase; Provisional; Region: PRK10150
632292000407	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632292000408	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
632292000409	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
632292000410	Protein of unknown function DUF72; Region: DUF72; pfam01904
632292000411	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
632292000412	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
632292000413	putative ligand binding site [chemical binding]; other site
632292000414	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
632292000415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000416	active site
632292000417	phosphorylation site [posttranslational modification]
632292000418	intermolecular recognition site; other site
632292000419	dimerization interface [polypeptide binding]; other site
632292000420	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000421	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000422	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292000423	dimerization interface [polypeptide binding]; other site
632292000424	Histidine kinase; Region: His_kinase; pfam06580
632292000425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000426	ATP binding site [chemical binding]; other site
632292000427	Mg2+ binding site [ion binding]; other site
632292000428	G-X-G motif; other site
632292000429	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
632292000430	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
632292000431	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
632292000432	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
632292000433	putative ligand binding site [chemical binding]; other site
632292000434	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
632292000435	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632292000436	Walker A/P-loop; other site
632292000437	ATP binding site [chemical binding]; other site
632292000438	Q-loop/lid; other site
632292000439	ABC transporter signature motif; other site
632292000440	Walker B; other site
632292000441	D-loop; other site
632292000442	H-loop/switch region; other site
632292000443	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632292000444	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292000445	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632292000446	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292000447	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632292000448	TM-ABC transporter signature motif; other site
632292000449	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292000450	dimerization interface [polypeptide binding]; other site
632292000451	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292000452	dimer interface [polypeptide binding]; other site
632292000453	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632292000454	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292000455	dimer interface [polypeptide binding]; other site
632292000456	putative CheW interface [polypeptide binding]; other site
632292000457	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
632292000458	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
632292000459	putative ligand binding site [chemical binding]; other site
632292000460	Response regulator receiver domain; Region: Response_reg; pfam00072
632292000461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000462	active site
632292000463	phosphorylation site [posttranslational modification]
632292000464	intermolecular recognition site; other site
632292000465	dimerization interface [polypeptide binding]; other site
632292000466	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000467	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292000468	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000469	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632292000470	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292000471	dimerization interface [polypeptide binding]; other site
632292000472	Histidine kinase; Region: His_kinase; pfam06580
632292000473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000474	Mg2+ binding site [ion binding]; other site
632292000475	G-X-G motif; other site
632292000476	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
632292000477	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
632292000478	ligand binding site [chemical binding]; other site
632292000479	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
632292000480	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
632292000481	ligand binding site [chemical binding]; other site
632292000482	calcium binding site [ion binding]; other site
632292000483	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
632292000484	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632292000485	Walker A/P-loop; other site
632292000486	ATP binding site [chemical binding]; other site
632292000487	Q-loop/lid; other site
632292000488	ABC transporter signature motif; other site
632292000489	Walker B; other site
632292000490	D-loop; other site
632292000491	H-loop/switch region; other site
632292000492	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632292000493	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292000494	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632292000495	TM-ABC transporter signature motif; other site
632292000496	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
632292000497	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
632292000498	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
632292000499	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
632292000500	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292000501	Walker A/P-loop; other site
632292000502	ATP binding site [chemical binding]; other site
632292000503	Q-loop/lid; other site
632292000504	ABC transporter signature motif; other site
632292000505	Walker B; other site
632292000506	D-loop; other site
632292000507	H-loop/switch region; other site
632292000508	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632292000509	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632292000510	Walker A/P-loop; other site
632292000511	ATP binding site [chemical binding]; other site
632292000512	Q-loop/lid; other site
632292000513	ABC transporter signature motif; other site
632292000514	Walker B; other site
632292000515	D-loop; other site
632292000516	H-loop/switch region; other site
632292000517	Predicted transcriptional regulators [Transcription]; Region: COG1725
632292000518	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292000519	DNA-binding site [nucleotide binding]; DNA binding site
632292000520	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
632292000521	nucleoside/Zn binding site; other site
632292000522	dimer interface [polypeptide binding]; other site
632292000523	catalytic motif [active]
632292000524	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
632292000525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
632292000526	ATP binding site [chemical binding]; other site
632292000527	Mg2+ binding site [ion binding]; other site
632292000528	G-X-G motif; other site
632292000529	Pectinesterase; Region: Pectinesterase; pfam01095
632292000530	putative pectinesterase; Region: PLN02432; cl01911
632292000531	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632292000532	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292000533	putative DNA binding site [nucleotide binding]; other site
632292000534	putative Zn2+ binding site [ion binding]; other site
632292000535	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632292000536	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
632292000537	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
632292000538	N- and C-terminal domain interface [polypeptide binding]; other site
632292000539	putative active site [active]
632292000540	MgATP binding site [chemical binding]; other site
632292000541	catalytic site [active]
632292000542	metal binding site [ion binding]; metal-binding site
632292000543	putative xylulose binding site [chemical binding]; other site
632292000544	putative homodimer interface [polypeptide binding]; other site
632292000545	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
632292000546	intersubunit interface [polypeptide binding]; other site
632292000547	active site
632292000548	zinc binding site [ion binding]; other site
632292000549	Na+ binding site [ion binding]; other site
632292000550	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
632292000551	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
632292000552	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
632292000553	glyoxylate reductase; Reviewed; Region: PRK13243
632292000554	dimerization interface [polypeptide binding]; other site
632292000555	ligand binding site [chemical binding]; other site
632292000556	NADP binding site [chemical binding]; other site
632292000557	catalytic site [active]
632292000558	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
632292000559	Transcriptional regulator [Transcription]; Region: IclR; COG1414
632292000560	Bacterial transcriptional regulator; Region: IclR; pfam01614
632292000561	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
632292000562	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
632292000563	active site
632292000564	intersubunit interface [polypeptide binding]; other site
632292000565	catalytic residue [active]
632292000566	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
632292000567	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
632292000568	substrate binding site [chemical binding]; other site
632292000569	ATP binding site [chemical binding]; other site
632292000570	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
632292000571	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
632292000572	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
632292000573	NADP binding site [chemical binding]; other site
632292000574	homodimer interface [polypeptide binding]; other site
632292000575	active site
632292000576	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
632292000577	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
632292000578	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
632292000579	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000580	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000581	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292000582	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000583	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000584	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000586	dimer interface [polypeptide binding]; other site
632292000587	conserved gate region; other site
632292000588	putative PBP binding loops; other site
632292000589	ABC-ATPase subunit interface; other site
632292000590	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000592	dimer interface [polypeptide binding]; other site
632292000593	conserved gate region; other site
632292000594	putative PBP binding loops; other site
632292000595	ABC-ATPase subunit interface; other site
632292000596	Response regulator receiver domain; Region: Response_reg; pfam00072
632292000597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000598	active site
632292000599	phosphorylation site [posttranslational modification]
632292000600	intermolecular recognition site; other site
632292000601	dimerization interface [polypeptide binding]; other site
632292000602	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292000603	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000604	Histidine kinase; Region: His_kinase; pfam06580
632292000605	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000606	ATP binding site [chemical binding]; other site
632292000607	Mg2+ binding site [ion binding]; other site
632292000608	G-X-G motif; other site
632292000609	Glycosyl hydrolase family 43; Region: GH43_2; cd08981
632292000610	active site
632292000611	Transposase domain (DUF772); Region: DUF772; pfam05598
632292000612	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
632292000613	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
632292000614	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
632292000615	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
632292000616	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
632292000617	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
632292000618	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
632292000619	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632292000620	Walker A/P-loop; other site
632292000621	ATP binding site [chemical binding]; other site
632292000622	Q-loop/lid; other site
632292000623	ABC transporter signature motif; other site
632292000624	Walker B; other site
632292000625	D-loop; other site
632292000626	H-loop/switch region; other site
632292000627	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
632292000628	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
632292000629	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
632292000630	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
632292000631	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
632292000632	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
632292000633	Soluble P-type ATPase [General function prediction only]; Region: COG4087
632292000634	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
632292000635	Cupin domain; Region: Cupin_2; pfam07883
632292000636	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
632292000637	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
632292000638	putative active site [active]
632292000639	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
632292000640	4Fe-4S binding domain; Region: Fer4; pfam00037
632292000641	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
632292000642	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
632292000643	active site
632292000644	FMN binding site [chemical binding]; other site
632292000645	substrate binding site [chemical binding]; other site
632292000646	3Fe-4S cluster binding site [ion binding]; other site
632292000647	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
632292000648	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
632292000649	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
632292000650	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632292000651	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
632292000652	putative subunit interface; other site
632292000653	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292000654	Zn2+ binding site [ion binding]; other site
632292000655	Mg2+ binding site [ion binding]; other site
632292000656	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
632292000657	L-lactate permease; Region: Lactate_perm; cl00701
632292000658	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
632292000659	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000660	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000661	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292000662	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292000663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000664	ABC-ATPase subunit interface; other site
632292000665	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000666	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000667	dimer interface [polypeptide binding]; other site
632292000668	conserved gate region; other site
632292000669	ABC-ATPase subunit interface; other site
632292000670	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
632292000671	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
632292000672	NAD binding site [chemical binding]; other site
632292000673	sugar binding site [chemical binding]; other site
632292000674	divalent metal binding site [ion binding]; other site
632292000675	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
632292000676	dimer interface [polypeptide binding]; other site
632292000677	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
632292000678	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
632292000679	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
632292000680	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
632292000681	metal binding site [ion binding]; metal-binding site
632292000682	active site
632292000683	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632292000684	dimer interface [polypeptide binding]; other site
632292000685	phosphorylation site [posttranslational modification]
632292000686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000687	ATP binding site [chemical binding]; other site
632292000688	Mg2+ binding site [ion binding]; other site
632292000689	G-X-G motif; other site
632292000690	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632292000691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000692	active site
632292000693	phosphorylation site [posttranslational modification]
632292000694	intermolecular recognition site; other site
632292000695	dimerization interface [polypeptide binding]; other site
632292000696	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632292000697	DNA binding site [nucleotide binding]
632292000698	ABC-2 type transporter; Region: ABC2_membrane; cl17235
632292000699	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292000700	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
632292000701	Walker A/P-loop; other site
632292000702	ATP binding site [chemical binding]; other site
632292000703	Q-loop/lid; other site
632292000704	ABC transporter signature motif; other site
632292000705	Walker B; other site
632292000706	D-loop; other site
632292000707	H-loop/switch region; other site
632292000708	Predicted transcriptional regulators [Transcription]; Region: COG1725
632292000709	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292000710	DNA-binding site [nucleotide binding]; DNA binding site
632292000711	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292000712	TraX protein; Region: TraX; pfam05857
632292000713	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632292000714	active site
632292000715	NTP binding site [chemical binding]; other site
632292000716	metal binding triad [ion binding]; metal-binding site
632292000717	antibiotic binding site [chemical binding]; other site
632292000718	Protein of unknown function DUF86; Region: DUF86; pfam01934
632292000719	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
632292000720	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
632292000721	FMN binding site [chemical binding]; other site
632292000722	active site
632292000723	catalytic residues [active]
632292000724	substrate binding site [chemical binding]; other site
632292000725	S-layer homology domain; Region: SLH; pfam00395
632292000726	S-layer homology domain; Region: SLH; pfam00395
632292000727	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
632292000728	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
632292000729	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
632292000730	protein binding site [polypeptide binding]; other site
632292000731	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
632292000732	Catalytic dyad [active]
632292000733	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
632292000734	rod shape-determining protein Mbl; Provisional; Region: PRK13928
632292000735	MreB and similar proteins; Region: MreB_like; cd10225
632292000736	nucleotide binding site [chemical binding]; other site
632292000737	Mg binding site [ion binding]; other site
632292000738	putative protofilament interaction site [polypeptide binding]; other site
632292000739	RodZ interaction site [polypeptide binding]; other site
632292000740	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
632292000741	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
632292000742	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
632292000743	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
632292000744	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
632292000745	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
632292000746	Rod binding protein; Region: Rod-binding; pfam10135
632292000747	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
632292000748	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632292000749	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632292000750	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
632292000751	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
632292000752	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000754	dimer interface [polypeptide binding]; other site
632292000755	conserved gate region; other site
632292000756	putative PBP binding loops; other site
632292000757	ABC-ATPase subunit interface; other site
632292000758	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292000759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000760	dimer interface [polypeptide binding]; other site
632292000761	conserved gate region; other site
632292000762	putative PBP binding loops; other site
632292000763	ABC-ATPase subunit interface; other site
632292000764	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000765	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000766	Helix-turn-helix domain; Region: HTH_18; pfam12833
632292000767	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000768	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
632292000769	TPP-binding site [chemical binding]; other site
632292000770	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
632292000771	PYR/PP interface [polypeptide binding]; other site
632292000772	dimer interface [polypeptide binding]; other site
632292000773	TPP binding site [chemical binding]; other site
632292000774	Predicted permeases [General function prediction only]; Region: COG0679
632292000775	H+ Antiporter protein; Region: 2A0121; TIGR00900
632292000776	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292000777	putative substrate translocation pore; other site
632292000778	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
632292000779	active site
632292000780	catalytic triad [active]
632292000781	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
632292000782	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
632292000783	active site
632292000784	substrate binding site [chemical binding]; other site
632292000785	metal binding site [ion binding]; metal-binding site
632292000786	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
632292000787	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
632292000788	glutaminase active site [active]
632292000789	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
632292000790	dimer interface [polypeptide binding]; other site
632292000791	active site
632292000792	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
632292000793	dimer interface [polypeptide binding]; other site
632292000794	active site
632292000795	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
632292000796	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
632292000797	Cl- selectivity filter; other site
632292000798	Cl- binding residues [ion binding]; other site
632292000799	pore gating glutamate residue; other site
632292000800	dimer interface [polypeptide binding]; other site
632292000801	H+/Cl- coupling transport residue; other site
632292000802	TrkA-C domain; Region: TrkA_C; pfam02080
632292000803	Predicted transcriptional regulators [Transcription]; Region: COG1733
632292000804	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292000805	dimerization interface [polypeptide binding]; other site
632292000806	putative DNA binding site [nucleotide binding]; other site
632292000807	putative Zn2+ binding site [ion binding]; other site
632292000808	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
632292000809	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
632292000810	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
632292000811	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292000812	non-specific DNA binding site [nucleotide binding]; other site
632292000813	salt bridge; other site
632292000814	sequence-specific DNA binding site [nucleotide binding]; other site
632292000815	DNA polymerase IV; Reviewed; Region: PRK03103
632292000816	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
632292000817	active site
632292000818	DNA binding site [nucleotide binding]
632292000819	Yip1 domain; Region: Yip1; pfam04893
632292000820	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
632292000821	HlyD family secretion protein; Region: HlyD_3; pfam13437
632292000822	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
632292000823	carboxyltransferase (CT) interaction site; other site
632292000824	biotinylation site [posttranslational modification]; other site
632292000825	HlyD family secretion protein; Region: HlyD_3; pfam13437
632292000826	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
632292000827	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
632292000828	FtsX-like permease family; Region: FtsX; pfam02687
632292000829	SurA N-terminal domain; Region: SurA_N_3; cl07813
632292000830	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
632292000831	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
632292000832	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
632292000833	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
632292000834	Walker A/P-loop; other site
632292000835	ATP binding site [chemical binding]; other site
632292000836	Q-loop/lid; other site
632292000837	ABC transporter signature motif; other site
632292000838	Walker B; other site
632292000839	D-loop; other site
632292000840	H-loop/switch region; other site
632292000841	Protein of unknown function (DUF970); Region: DUF970; cl17525
632292000842	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
632292000843	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
632292000844	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
632292000845	Iron permease FTR1 family; Region: FTR1; cl00475
632292000846	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
632292000847	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
632292000848	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
632292000849	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
632292000850	Ligand Binding Site [chemical binding]; other site
632292000851	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632292000852	putative active site [active]
632292000853	Peptidase family C69; Region: Peptidase_C69; cl17793
632292000854	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292000855	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
632292000856	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
632292000857	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
632292000858	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
632292000859	Rrf2 family protein; Region: rrf2_super; TIGR00738
632292000860	Transcriptional regulator; Region: Rrf2; pfam02082
632292000861	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
632292000862	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632292000863	ACS interaction site; other site
632292000864	CODH interaction site; other site
632292000865	metal cluster binding site [ion binding]; other site
632292000866	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
632292000867	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
632292000868	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632292000869	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000870	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292000871	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292000872	putative alcohol dehydrogenase; Provisional; Region: PRK09860
632292000873	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
632292000874	dimer interface [polypeptide binding]; other site
632292000875	active site
632292000876	metal binding site [ion binding]; metal-binding site
632292000877	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
632292000878	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
632292000879	Ca binding site [ion binding]; other site
632292000880	active site
632292000881	catalytic site [active]
632292000882	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292000883	S-adenosylmethionine binding site [chemical binding]; other site
632292000884	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
632292000885	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
632292000886	Methyltransferase domain; Region: Methyltransf_31; pfam13847
632292000887	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292000888	S-adenosylmethionine binding site [chemical binding]; other site
632292000889	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632292000890	Probable transposase; Region: OrfB_IS605; pfam01385
632292000891	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632292000892	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
632292000893	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
632292000894	DNA binding residues [nucleotide binding]
632292000895	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
632292000896	catalytic residues [active]
632292000897	catalytic nucleophile [active]
632292000898	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
632292000899	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632292000900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292000901	active site
632292000902	phosphorylation site [posttranslational modification]
632292000903	intermolecular recognition site; other site
632292000904	dimerization interface [polypeptide binding]; other site
632292000905	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632292000906	DNA binding site [nucleotide binding]
632292000907	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632292000908	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
632292000909	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632292000910	dimer interface [polypeptide binding]; other site
632292000911	phosphorylation site [posttranslational modification]
632292000912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292000913	ATP binding site [chemical binding]; other site
632292000914	Mg2+ binding site [ion binding]; other site
632292000915	G-X-G motif; other site
632292000916	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632292000917	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632292000918	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
632292000919	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
632292000920	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
632292000921	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
632292000922	B12 binding site [chemical binding]; other site
632292000923	cobalt ligand [ion binding]; other site
632292000924	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632292000925	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
632292000926	intersubunit interface [polypeptide binding]; other site
632292000927	active site
632292000928	Zn2+ binding site [ion binding]; other site
632292000929	maltodextrin glucosidase; Provisional; Region: PRK10785
632292000930	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
632292000931	homodimer interface [polypeptide binding]; other site
632292000932	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
632292000933	active site
632292000934	homodimer interface [polypeptide binding]; other site
632292000935	catalytic site [active]
632292000936	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292000937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000938	putative PBP binding loops; other site
632292000939	ABC-ATPase subunit interface; other site
632292000940	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000942	dimer interface [polypeptide binding]; other site
632292000943	conserved gate region; other site
632292000944	putative PBP binding loops; other site
632292000945	ABC-ATPase subunit interface; other site
632292000946	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
632292000947	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
632292000948	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292000949	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292000950	DNA binding site [nucleotide binding]
632292000951	domain linker motif; other site
632292000952	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
632292000953	putative dimerization interface [polypeptide binding]; other site
632292000954	putative ligand binding site [chemical binding]; other site
632292000955	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
632292000956	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000957	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
632292000958	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
632292000959	Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029
632292000960	Glycosyl hydrolase family 43; Region: GH43_5; cd08984
632292000961	active site
632292000962	MoxR-like ATPases [General function prediction only]; Region: COG0714
632292000963	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292000964	Walker A motif; other site
632292000965	ATP binding site [chemical binding]; other site
632292000966	Walker B motif; other site
632292000967	arginine finger; other site
632292000968	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
632292000969	dimer interface [polypeptide binding]; other site
632292000970	substrate binding site [chemical binding]; other site
632292000971	metal binding site [ion binding]; metal-binding site
632292000972	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
632292000973	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
632292000974	dimerization interface [polypeptide binding]; other site
632292000975	putative active cleft [active]
632292000976	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292000977	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292000978	DNA binding site [nucleotide binding]
632292000979	domain linker motif; other site
632292000980	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
632292000981	Domain of unknown function (DUF377); Region: DUF377; pfam04041
632292000982	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
632292000983	active site
632292000984	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292000985	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000986	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292000987	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292000988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000989	dimer interface [polypeptide binding]; other site
632292000990	conserved gate region; other site
632292000991	putative PBP binding loops; other site
632292000992	ABC-ATPase subunit interface; other site
632292000993	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292000994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292000995	dimer interface [polypeptide binding]; other site
632292000996	conserved gate region; other site
632292000997	ABC-ATPase subunit interface; other site
632292000998	HAMP domain; Region: HAMP; pfam00672
632292000999	Histidine kinase; Region: His_kinase; pfam06580
632292001000	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292001001	ATP binding site [chemical binding]; other site
632292001002	Mg2+ binding site [ion binding]; other site
632292001003	G-X-G motif; other site
632292001004	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
632292001005	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
632292001006	THF binding site; other site
632292001007	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
632292001008	substrate binding site [chemical binding]; other site
632292001009	THF binding site; other site
632292001010	zinc-binding site [ion binding]; other site
632292001011	AAA ATPase domain; Region: AAA_15; pfam13175
632292001012	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292001013	Walker A/P-loop; other site
632292001014	ATP binding site [chemical binding]; other site
632292001015	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
632292001016	putative active site [active]
632292001017	putative metal-binding site [ion binding]; other site
632292001018	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
632292001019	PLD-like domain; Region: PLDc_2; pfam13091
632292001020	putative homodimer interface [polypeptide binding]; other site
632292001021	putative active site [active]
632292001022	catalytic site [active]
632292001023	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292001024	ATP binding site [chemical binding]; other site
632292001025	putative Mg++ binding site [ion binding]; other site
632292001026	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632292001027	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
632292001028	nucleotide binding region [chemical binding]; other site
632292001029	ATP-binding site [chemical binding]; other site
632292001030	Transposase domain (DUF772); Region: DUF772; pfam05598
632292001031	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
632292001032	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
632292001033	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
632292001034	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
632292001035	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
632292001036	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
632292001037	AAA domain; Region: AAA_26; pfam13500
632292001038	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
632292001039	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
632292001040	inhibitor-cofactor binding pocket; inhibition site
632292001041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292001042	catalytic residue [active]
632292001043	biotin synthase; Region: bioB; TIGR00433
632292001044	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292001045	FeS/SAM binding site; other site
632292001046	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
632292001047	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
632292001048	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
632292001049	Int/Topo IB signature motif; other site
632292001050	Domain of unknown function (DUF955); Region: DUF955; pfam06114
632292001051	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292001052	non-specific DNA binding site [nucleotide binding]; other site
632292001053	salt bridge; other site
632292001054	sequence-specific DNA binding site [nucleotide binding]; other site
632292001055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
632292001056	sequence-specific DNA binding site [nucleotide binding]; other site
632292001057	salt bridge; other site
632292001058	Helix-turn-helix domain; Region: HTH_17; pfam12728
632292001059	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
632292001060	DNA-binding interface [nucleotide binding]; DNA binding site
632292001061	PrgI family protein; Region: PrgI; pfam12666
632292001062	Domain of unknown function DUF87; Region: DUF87; pfam01935
632292001063	AAA-like domain; Region: AAA_10; pfam12846
632292001064	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
632292001065	Mg binding site [ion binding]; other site
632292001066	nucleotide binding site [chemical binding]; other site
632292001067	putative protofilament interface [polypeptide binding]; other site
632292001068	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
632292001069	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
632292001070	Walker A motif; other site
632292001071	ATP binding site [chemical binding]; other site
632292001072	Walker B motif; other site
632292001073	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292001074	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632292001075	FeS/SAM binding site; other site
632292001076	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
632292001077	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
632292001078	RNA binding site [nucleotide binding]; other site
632292001079	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
632292001080	RNA binding site [nucleotide binding]; other site
632292001081	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
632292001082	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
632292001083	IHF dimer interface [polypeptide binding]; other site
632292001084	IHF - DNA interface [nucleotide binding]; other site
632292001085	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cl00315
632292001086	RRXRR protein; Region: RRXRR; pfam14239
632292001087	glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135
632292001088	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632292001089	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
632292001090	hypothetical protein; Validated; Region: PRK08116
632292001091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292001092	Walker A motif; other site
632292001093	ATP binding site [chemical binding]; other site
632292001094	Walker B motif; other site
632292001095	arginine finger; other site
632292001096	Helix-turn-helix domain; Region: HTH_36; pfam13730
632292001097	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
632292001098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
632292001099	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
632292001100	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292001101	non-specific DNA binding site [nucleotide binding]; other site
632292001102	salt bridge; other site
632292001103	sequence-specific DNA binding site [nucleotide binding]; other site
632292001104	PemK-like protein; Region: PemK; pfam02452
632292001105	glutamate dehydrogenase; Provisional; Region: PRK14030
632292001106	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
632292001107	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632292001108	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
632292001109	hypothetical protein; Validated; Region: PRK08116
632292001110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292001111	Walker A motif; other site
632292001112	ATP binding site [chemical binding]; other site
632292001113	Walker B motif; other site
632292001114	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
632292001115	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
632292001116	Methyltransferase domain; Region: Methyltransf_26; pfam13659
632292001117	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
632292001118	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
632292001119	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
632292001120	YcfA-like protein; Region: YcfA; pfam07927
632292001121	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
632292001122	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292001123	non-specific DNA binding site [nucleotide binding]; other site
632292001124	salt bridge; other site
632292001125	sequence-specific DNA binding site [nucleotide binding]; other site
632292001126	Domain of unknown function (DUF955); Region: DUF955; pfam06114
632292001127	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
632292001128	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
632292001129	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
632292001130	Walker A motif; other site
632292001131	ATP binding site [chemical binding]; other site
632292001132	Walker B motif; other site
632292001133	Methyltransferase domain; Region: Methyltransf_23; pfam13489
632292001134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292001135	S-adenosylmethionine binding site [chemical binding]; other site
632292001136	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
632292001137	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
632292001138	active site
632292001139	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
632292001140	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
632292001141	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
632292001142	dimer interface [polypeptide binding]; other site
632292001143	ssDNA binding site [nucleotide binding]; other site
632292001144	tetramer (dimer of dimers) interface [polypeptide binding]; other site
632292001145	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292001146	Zn2+ binding site [ion binding]; other site
632292001147	Mg2+ binding site [ion binding]; other site
632292001148	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
632292001149	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
632292001150	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
632292001151	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
632292001152	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
632292001153	N-acetyl-D-glucosamine binding site [chemical binding]; other site
632292001154	catalytic residue [active]
632292001155	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
632292001156	Peptidase family M23; Region: Peptidase_M23; pfam01551
632292001157	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292001158	putative DNA binding site [nucleotide binding]; other site
632292001159	putative Zn2+ binding site [ion binding]; other site
632292001160	rod shape-determining protein MreC; Provisional; Region: PRK13922
632292001161	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
632292001162	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
632292001163	active site
632292001164	DNA binding site [nucleotide binding]
632292001165	Int/Topo IB signature motif; other site
632292001166	HaeIII restriction endonuclease; Region: RE_HaeIII; pfam09556
632292001167	HaeIII restriction endonuclease; Region: RE_HaeIII; pfam09556
632292001168	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
632292001169	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292001170	sequence-specific DNA binding site [nucleotide binding]; other site
632292001171	salt bridge; other site
632292001172	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292001173	non-specific DNA binding site [nucleotide binding]; other site
632292001174	salt bridge; other site
632292001175	sequence-specific DNA binding site [nucleotide binding]; other site
632292001176	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
632292001177	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
632292001178	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292001179	non-specific DNA binding site [nucleotide binding]; other site
632292001180	salt bridge; other site
632292001181	sequence-specific DNA binding site [nucleotide binding]; other site
632292001182	replicative DNA helicase; Region: DnaB; TIGR00665
632292001183	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
632292001184	Walker A motif; other site
632292001185	ATP binding site [chemical binding]; other site
632292001186	Walker B motif; other site
632292001187	DNA binding loops [nucleotide binding]
632292001188	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
632292001189	RNA/DNA hybrid binding site [nucleotide binding]; other site
632292001190	active site
632292001191	SWIM zinc finger; Region: SWIM; pfam04434
632292001192	RRXRR protein; Region: RRXRR; pfam14239
632292001193	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
632292001194	active site
632292001195	RNA polymerase factor sigma-70; Validated; Region: PRK08295
632292001196	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292001197	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292001198	DNA binding residues [nucleotide binding]
632292001199	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
632292001200	RecT family; Region: RecT; pfam03837
632292001201	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
632292001202	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
632292001203	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
632292001204	DNA primase, catalytic core; Region: dnaG; TIGR01391
632292001205	CHC2 zinc finger; Region: zf-CHC2; cl17510
632292001206	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
632292001207	Domain of unknown function (DUF2828); Region: DUF2828; pfam11443
632292001208	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
632292001209	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
632292001210	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
632292001211	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
632292001212	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632292001213	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
632292001214	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
632292001215	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632292001216	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632292001217	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292001218	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292001219	DNA binding site [nucleotide binding]
632292001220	domain linker motif; other site
632292001221	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
632292001222	dimerization interface [polypeptide binding]; other site
632292001223	ligand binding site [chemical binding]; other site
632292001224	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292001225	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292001226	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
632292001227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292001228	dimer interface [polypeptide binding]; other site
632292001229	conserved gate region; other site
632292001230	putative PBP binding loops; other site
632292001231	ABC-ATPase subunit interface; other site
632292001232	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292001233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292001234	dimer interface [polypeptide binding]; other site
632292001235	conserved gate region; other site
632292001236	putative PBP binding loops; other site
632292001237	ABC-ATPase subunit interface; other site
632292001238	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632292001239	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632292001240	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292001241	dimer interface [polypeptide binding]; other site
632292001242	putative CheW interface [polypeptide binding]; other site
632292001243	Cache domain; Region: Cache_1; pfam02743
632292001244	oxaloacetate decarboxylase; Provisional; Region: PRK12331
632292001245	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
632292001246	active site
632292001247	catalytic residues [active]
632292001248	metal binding site [ion binding]; metal-binding site
632292001249	homodimer binding site [polypeptide binding]; other site
632292001250	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
632292001251	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
632292001252	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
632292001253	carboxyltransferase (CT) interaction site; other site
632292001254	biotinylation site [posttranslational modification]; other site
632292001255	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
632292001256	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292001257	dimerization interface [polypeptide binding]; other site
632292001258	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632292001259	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292001260	dimer interface [polypeptide binding]; other site
632292001261	putative CheW interface [polypeptide binding]; other site
632292001262	S-layer homology domain; Region: SLH; pfam00395
632292001263	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
632292001264	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292001265	Zn2+ binding site [ion binding]; other site
632292001266	Mg2+ binding site [ion binding]; other site
632292001267	Uncharacterized conserved protein [Function unknown]; Region: COG3465
632292001268	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
632292001269	E3 interaction surface; other site
632292001270	lipoyl attachment site [posttranslational modification]; other site
632292001271	HlyD family secretion protein; Region: HlyD_3; pfam13437
632292001272	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
632292001273	HlyD family secretion protein; Region: HlyD_3; pfam13437
632292001274	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632292001275	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
632292001276	Walker A/P-loop; other site
632292001277	ATP binding site [chemical binding]; other site
632292001278	Q-loop/lid; other site
632292001279	ABC transporter signature motif; other site
632292001280	Walker B; other site
632292001281	D-loop; other site
632292001282	H-loop/switch region; other site
632292001283	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
632292001284	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
632292001285	FtsX-like permease family; Region: FtsX; pfam02687
632292001286	S-layer homology domain; Region: SLH; pfam00395
632292001287	S-layer homology domain; Region: SLH; pfam00395
632292001288	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632292001289	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
632292001290	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292001291	S-adenosylmethionine binding site [chemical binding]; other site
632292001292	FOG: CBS domain [General function prediction only]; Region: COG0517
632292001293	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
632292001294	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
632292001295	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
632292001296	Transposase IS200 like; Region: Y1_Tnp; pfam01797
632292001297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632292001298	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
632292001299	Probable transposase; Region: OrfB_IS605; pfam01385
632292001300	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632292001301	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
632292001302	putative DNA binding helix; other site
632292001303	metal binding site 2 [ion binding]; metal-binding site
632292001304	metal binding site 1 [ion binding]; metal-binding site
632292001305	dimer interface [polypeptide binding]; other site
632292001306	structural Zn2+ binding site [ion binding]; other site
632292001307	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
632292001308	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
632292001309	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
632292001310	DNA binding residues [nucleotide binding]
632292001311	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
632292001312	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
632292001313	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
632292001314	metal-binding site [ion binding]
632292001315	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
632292001316	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
632292001317	metal-binding site [ion binding]
632292001318	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
632292001319	Soluble P-type ATPase [General function prediction only]; Region: COG4087
632292001320	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
632292001321	metal-binding site [ion binding]
632292001322	Protein of unknown function (DUF1646); Region: DUF1646; pfam07854
632292001323	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632292001324	active site
632292001325	NTP binding site [chemical binding]; other site
632292001326	metal binding triad [ion binding]; metal-binding site
632292001327	antibiotic binding site [chemical binding]; other site
632292001328	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
632292001329	Transposase domain (DUF772); Region: DUF772; pfam05598
632292001330	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
632292001331	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
632292001332	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
632292001333	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292001334	FeS/SAM binding site; other site
632292001335	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
632292001336	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
632292001337	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632292001338	Walker A/P-loop; other site
632292001339	ATP binding site [chemical binding]; other site
632292001340	Q-loop/lid; other site
632292001341	ABC transporter signature motif; other site
632292001342	Walker B; other site
632292001343	D-loop; other site
632292001344	H-loop/switch region; other site
632292001345	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632292001346	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632292001347	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
632292001348	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632292001349	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
632292001350	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632292001351	Walker A/P-loop; other site
632292001352	ATP binding site [chemical binding]; other site
632292001353	Q-loop/lid; other site
632292001354	ABC transporter signature motif; other site
632292001355	Walker B; other site
632292001356	D-loop; other site
632292001357	H-loop/switch region; other site
632292001358	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632292001359	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632292001360	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292001361	TM-ABC transporter signature motif; other site
632292001362	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
632292001363	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
632292001364	ligand binding site [chemical binding]; other site
632292001365	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292001366	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292001367	DNA binding site [nucleotide binding]
632292001368	domain linker motif; other site
632292001369	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
632292001370	dimerization interface [polypeptide binding]; other site
632292001371	ligand binding site [chemical binding]; other site
632292001372	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292001373	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
632292001374	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292001375	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292001376	dimer interface [polypeptide binding]; other site
632292001377	conserved gate region; other site
632292001378	putative PBP binding loops; other site
632292001379	ABC-ATPase subunit interface; other site
632292001380	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292001381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292001382	dimer interface [polypeptide binding]; other site
632292001383	conserved gate region; other site
632292001384	putative PBP binding loops; other site
632292001385	ABC-ATPase subunit interface; other site
632292001386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
632292001387	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
632292001388	putative oxidoreductase; Provisional; Region: PRK12831
632292001389	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
632292001390	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
632292001391	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
632292001392	FAD binding pocket [chemical binding]; other site
632292001393	FAD binding motif [chemical binding]; other site
632292001394	phosphate binding motif [ion binding]; other site
632292001395	beta-alpha-beta structure motif; other site
632292001396	NAD binding pocket [chemical binding]; other site
632292001397	Iron coordination center [ion binding]; other site
632292001398	Transcriptional regulator [Transcription]; Region: IclR; COG1414
632292001399	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292001400	putative DNA binding site [nucleotide binding]; other site
632292001401	putative Zn2+ binding site [ion binding]; other site
632292001402	Bacterial transcriptional regulator; Region: IclR; pfam01614
632292001403	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
632292001404	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
632292001405	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
632292001406	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
632292001407	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
632292001408	substrate binding site [chemical binding]; other site
632292001409	ATP binding site [chemical binding]; other site
632292001410	C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
632292001411	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
632292001412	ligand binding site [chemical binding]; other site
632292001413	NAD binding site [chemical binding]; other site
632292001414	catalytic site [active]
632292001415	D-mannonate oxidoreductase; Provisional; Region: PRK08277
632292001416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632292001417	NAD(P) binding site [chemical binding]; other site
632292001418	active site
632292001419	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
632292001420	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
632292001421	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
632292001422	DctM-like transporters; Region: DctM; pfam06808
632292001423	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
632292001424	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
632292001425	classical (c) SDRs; Region: SDR_c; cd05233
632292001426	NAD(P) binding site [chemical binding]; other site
632292001427	active site
632292001428	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
632292001429	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292001430	Zn2+ binding site [ion binding]; other site
632292001431	Mg2+ binding site [ion binding]; other site
632292001432	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632292001433	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632292001434	Walker A/P-loop; other site
632292001435	ATP binding site [chemical binding]; other site
632292001436	Q-loop/lid; other site
632292001437	ABC transporter signature motif; other site
632292001438	Walker B; other site
632292001439	D-loop; other site
632292001440	H-loop/switch region; other site
632292001441	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
632292001442	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
632292001443	MoxR-like ATPases [General function prediction only]; Region: COG0714
632292001444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292001445	Walker A motif; other site
632292001446	ATP binding site [chemical binding]; other site
632292001447	Walker B motif; other site
632292001448	arginine finger; other site
632292001449	Protein of unknown function DUF58; Region: DUF58; pfam01882
632292001450	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
632292001451	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
632292001452	metal ion-dependent adhesion site (MIDAS); other site
632292001453	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
632292001454	metal ion-dependent adhesion site (MIDAS); other site
632292001455	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
632292001456	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
632292001457	metal ion-dependent adhesion site (MIDAS); other site
632292001458	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
632292001459	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
632292001460	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
632292001461	active site
632292001462	HIGH motif; other site
632292001463	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
632292001464	active site
632292001465	KMSKS motif; other site
632292001466	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
632292001467	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
632292001468	trimer interface [polypeptide binding]; other site
632292001469	active site
632292001470	substrate binding site [chemical binding]; other site
632292001471	CoA binding site [chemical binding]; other site
632292001472	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
632292001473	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
632292001474	active site
632292001475	HIGH motif; other site
632292001476	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
632292001477	KMSKS motif; other site
632292001478	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
632292001479	tRNA binding surface [nucleotide binding]; other site
632292001480	anticodon binding site; other site
632292001481	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
632292001482	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
632292001483	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632292001484	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632292001485	Walker A/P-loop; other site
632292001486	ATP binding site [chemical binding]; other site
632292001487	Q-loop/lid; other site
632292001488	ABC transporter signature motif; other site
632292001489	Walker B; other site
632292001490	D-loop; other site
632292001491	H-loop/switch region; other site
632292001492	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292001493	DNA-binding site [nucleotide binding]; DNA binding site
632292001494	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
632292001495	putative active site pocket [active]
632292001496	dimerization interface [polypeptide binding]; other site
632292001497	putative catalytic residue [active]
632292001498	Predicted transcriptional regulators [Transcription]; Region: COG1733
632292001499	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
632292001500	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
632292001501	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
632292001502	putative active site [active]
632292001503	metal binding site [ion binding]; metal-binding site
632292001504	Amino acid permease; Region: AA_permease_2; pfam13520
632292001505	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
632292001506	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
632292001507	Ethanolamine utilisation protein, EutH; Region: EutH; cl01248
632292001508	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632292001509	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632292001510	metal binding site [ion binding]; metal-binding site
632292001511	active site
632292001512	I-site; other site
632292001513	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
632292001514	ribulokinase; Provisional; Region: PRK04123
632292001515	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
632292001516	N- and C-terminal domain interface [polypeptide binding]; other site
632292001517	active site
632292001518	MgATP binding site [chemical binding]; other site
632292001519	catalytic site [active]
632292001520	metal binding site [ion binding]; metal-binding site
632292001521	carbohydrate binding site [chemical binding]; other site
632292001522	homodimer interface [polypeptide binding]; other site
632292001523	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292001524	DNA-binding site [nucleotide binding]; DNA binding site
632292001525	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292001526	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
632292001527	putative dimerization interface [polypeptide binding]; other site
632292001528	putative ligand binding site [chemical binding]; other site
632292001529	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
632292001530	intersubunit interface [polypeptide binding]; other site
632292001531	active site
632292001532	Zn2+ binding site [ion binding]; other site
632292001533	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
632292001534	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
632292001535	active site
632292001536	catalytic residues [active]
632292001537	metal binding site [ion binding]; metal-binding site
632292001538	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
632292001539	4Fe-4S binding domain; Region: Fer4; cl02805
632292001540	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
632292001541	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
632292001542	glutamine binding [chemical binding]; other site
632292001543	catalytic triad [active]
632292001544	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
632292001545	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
632292001546	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
632292001547	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
632292001548	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
632292001549	homodimer interface [polypeptide binding]; other site
632292001550	substrate-cofactor binding pocket; other site
632292001551	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292001552	catalytic residue [active]
632292001553	4Fe-4S binding domain; Region: Fer4_5; pfam12801
632292001554	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
632292001555	FMN-binding domain; Region: FMN_bind; cl01081
632292001556	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
632292001557	ApbE family; Region: ApbE; pfam02424
632292001558	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
632292001559	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
632292001560	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
632292001561	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
632292001562	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
632292001563	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_3; cd09321
632292001564	gating phenylalanine in ion channel; other site
632292001565	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
632292001566	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
632292001567	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
632292001568	active site 1 [active]
632292001569	active site 2 [active]
632292001570	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
632292001571	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
632292001572	Potassium binding sites [ion binding]; other site
632292001573	Cesium cation binding sites [ion binding]; other site
632292001574	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
632292001575	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
632292001576	substrate-cofactor binding pocket; other site
632292001577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292001578	catalytic residue [active]
632292001579	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
632292001580	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
632292001581	NAD(P) binding site [chemical binding]; other site
632292001582	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292001583	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292001584	DNA binding site [nucleotide binding]
632292001585	domain linker motif; other site
632292001586	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
632292001587	putative dimerization interface [polypeptide binding]; other site
632292001588	putative ligand binding site [chemical binding]; other site
632292001589	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
632292001590	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
632292001591	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
632292001592	Predicted methyltransferases [General function prediction only]; Region: COG1568
632292001593	6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625
632292001594	Uncharacterized conserved protein [Function unknown]; Region: COG0585
632292001595	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
632292001596	active site
632292001597	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
632292001598	putative acetyltransferase; Provisional; Region: PRK03624
632292001599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632292001600	Coenzyme A binding pocket [chemical binding]; other site
632292001601	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
632292001602	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
632292001603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292001604	Walker A motif; other site
632292001605	ATP binding site [chemical binding]; other site
632292001606	Walker B motif; other site
632292001607	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
632292001608	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
632292001609	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
632292001610	ABC-ATPase subunit  interface; other site
632292001611	dimer interface [polypeptide binding]; other site
632292001612	putative PBP binding regions; other site
632292001613	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
632292001614	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
632292001615	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
632292001616	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
632292001617	intersubunit interface [polypeptide binding]; other site
632292001618	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
632292001619	metal binding site 2 [ion binding]; metal-binding site
632292001620	putative DNA binding helix; other site
632292001621	metal binding site 1 [ion binding]; metal-binding site
632292001622	dimer interface [polypeptide binding]; other site
632292001623	structural Zn2+ binding site [ion binding]; other site
632292001624	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292001625	dimerization interface [polypeptide binding]; other site
632292001626	putative DNA binding site [nucleotide binding]; other site
632292001627	putative Zn2+ binding site [ion binding]; other site
632292001628	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292001629	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632292001630	FeS/SAM binding site; other site
632292001631	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
632292001632	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
632292001633	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
632292001634	hypothetical protein; Reviewed; Region: PRK09588
632292001635	DNA protecting protein DprA; Region: dprA; TIGR00732
632292001636	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
632292001637	DNA topoisomerase I; Validated; Region: PRK05582
632292001638	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
632292001639	active site
632292001640	interdomain interaction site; other site
632292001641	putative metal-binding site [ion binding]; other site
632292001642	nucleotide binding site [chemical binding]; other site
632292001643	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
632292001644	domain I; other site
632292001645	DNA binding groove [nucleotide binding]
632292001646	phosphate binding site [ion binding]; other site
632292001647	domain II; other site
632292001648	domain III; other site
632292001649	nucleotide binding site [chemical binding]; other site
632292001650	catalytic site [active]
632292001651	domain IV; other site
632292001652	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
632292001653	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
632292001654	RNA polymerase subunit 9; Region: RPOL9; smart00661
632292001655	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
632292001656	Glucose inhibited division protein A; Region: GIDA; pfam01134
632292001657	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
632292001658	active site
632292001659	HslU subunit interaction site [polypeptide binding]; other site
632292001660	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
632292001661	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292001662	Walker A motif; other site
632292001663	ATP binding site [chemical binding]; other site
632292001664	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
632292001665	Walker B motif; other site
632292001666	arginine finger; other site
632292001667	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
632292001668	transcriptional repressor CodY; Validated; Region: PRK04158
632292001669	CodY GAF-like domain; Region: CodY; pfam06018
632292001670	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
632292001671	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
632292001672	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
632292001673	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
632292001674	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
632292001675	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
632292001676	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
632292001677	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
632292001678	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
632292001679	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
632292001680	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
632292001681	FliG C-terminal domain; Region: FliG_C; pfam01706
632292001682	Flagellar assembly protein FliH; Region: FliH; pfam02108
632292001683	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
632292001684	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
632292001685	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
632292001686	Walker A motif/ATP binding site; other site
632292001687	Walker B motif; other site
632292001688	MgtE intracellular N domain; Region: MgtE_N; smart00924
632292001689	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
632292001690	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
632292001691	FlgD Tudor-like domain; Region: FLgD_tudor; cl17881
632292001692	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
632292001693	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
632292001694	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
632292001695	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
632292001696	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
632292001697	Flagellar protein (FlbD); Region: FlbD; pfam06289
632292001698	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
632292001699	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
632292001700	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
632292001701	flagellar motor switch protein; Validated; Region: PRK08119
632292001702	CheC-like family; Region: CheC; pfam04509
632292001703	CheC-like family; Region: CheC; pfam04509
632292001704	Sporulation related domain; Region: SPOR; cl10051
632292001705	flagellar motor switch protein FliN; Region: fliN; TIGR02480
632292001706	Response regulator receiver domain; Region: Response_reg; pfam00072
632292001707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292001708	active site
632292001709	phosphorylation site [posttranslational modification]
632292001710	intermolecular recognition site; other site
632292001711	dimerization interface [polypeptide binding]; other site
632292001712	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
632292001713	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
632292001714	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
632292001715	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
632292001716	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
632292001717	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
632292001718	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
632292001719	FHIPEP family; Region: FHIPEP; pfam00771
632292001720	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
632292001721	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
632292001722	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
632292001723	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
632292001724	P-loop; other site
632292001725	Flagellar protein YcgR; Region: YcgR_2; pfam12945
632292001726	PilZ domain; Region: PilZ; pfam07238
632292001727	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
632292001728	putative binding surface; other site
632292001729	active site
632292001730	P2 response regulator binding domain; Region: P2; pfam07194
632292001731	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
632292001732	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
632292001733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292001734	ATP binding site [chemical binding]; other site
632292001735	Mg2+ binding site [ion binding]; other site
632292001736	G-X-G motif; other site
632292001737	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
632292001738	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
632292001739	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
632292001740	CheC-like family; Region: CheC; pfam04509
632292001741	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
632292001742	CheC-like family; Region: CheC; pfam04509
632292001743	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488
632292001744	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
632292001745	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292001746	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292001747	DNA binding residues [nucleotide binding]
632292001748	Protein of unknown function (DUF342); Region: DUF342; pfam03961
632292001749	Cupin domain; Region: Cupin_2; pfam07883
632292001750	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
632292001751	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292001752	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292001753	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
632292001754	oligomerisation interface [polypeptide binding]; other site
632292001755	mobile loop; other site
632292001756	roof hairpin; other site
632292001757	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
632292001758	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
632292001759	ring oligomerisation interface [polypeptide binding]; other site
632292001760	ATP/Mg binding site [chemical binding]; other site
632292001761	stacking interactions; other site
632292001762	hinge regions; other site
632292001763	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292001764	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
632292001765	active site
632292001766	motif I; other site
632292001767	motif II; other site
632292001768	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292001769	Uncharacterized conserved protein [Function unknown]; Region: COG2006
632292001770	Domain of unknown function (DUF362); Region: DUF362; pfam04015
632292001771	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632292001772	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
632292001773	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292001774	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
632292001775	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
632292001776	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
632292001777	EDD domain protein, DegV family; Region: DegV; TIGR00762
632292001778	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
632292001779	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
632292001780	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292001781	FeS/SAM binding site; other site
632292001782	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
632292001783	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
632292001784	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
632292001785	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
632292001786	homodimer interface [polypeptide binding]; other site
632292001787	oligonucleotide binding site [chemical binding]; other site
632292001788	elongation factor P; Validated; Region: PRK00529
632292001789	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
632292001790	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
632292001791	RNA binding site [nucleotide binding]; other site
632292001792	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
632292001793	RNA binding site [nucleotide binding]; other site
632292001794	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
632292001795	homodimer interface [polypeptide binding]; other site
632292001796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292001797	catalytic residue [active]
632292001798	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
632292001799	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
632292001800	ligand binding site [chemical binding]; other site
632292001801	NAD binding site [chemical binding]; other site
632292001802	dimerization interface [polypeptide binding]; other site
632292001803	catalytic site [active]
632292001804	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
632292001805	putative L-serine binding site [chemical binding]; other site
632292001806	Uncharacterized conserved protein [Function unknown]; Region: COG4198
632292001807	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
632292001808	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
632292001809	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292001810	motif II; other site
632292001811	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292001812	motif II; other site
632292001813	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
632292001814	Fic family protein [Function unknown]; Region: COG3177
632292001815	Fic/DOC family; Region: Fic; pfam02661
632292001816	Fic/DOC family; Region: Fic; cl00960
632292001817	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
632292001818	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
632292001819	putative substrate binding site [chemical binding]; other site
632292001820	putative ATP binding site [chemical binding]; other site
632292001821	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
632292001822	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
632292001823	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
632292001824	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
632292001825	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
632292001826	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292001827	Zn2+ binding site [ion binding]; other site
632292001828	Mg2+ binding site [ion binding]; other site
632292001829	ribonuclease R; Region: RNase_R; TIGR02063
632292001830	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
632292001831	RNA binding site [nucleotide binding]; other site
632292001832	RNA binding site [nucleotide binding]; other site
632292001833	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
632292001834	RNB domain; Region: RNB; pfam00773
632292001835	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
632292001836	RNA binding site [nucleotide binding]; other site
632292001837	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
632292001838	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292001839	Walker A motif; other site
632292001840	ATP binding site [chemical binding]; other site
632292001841	Walker B motif; other site
632292001842	arginine finger; other site
632292001843	Domain of unknown function (DUF362); Region: DUF362; pfam04015
632292001844	Uncharacterized conserved protein [Function unknown]; Region: COG2006
632292001845	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
632292001846	30S subunit binding site; other site
632292001847	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
632292001848	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292001849	ATP binding site [chemical binding]; other site
632292001850	putative Mg++ binding site [ion binding]; other site
632292001851	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
632292001852	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632292001853	nucleotide binding region [chemical binding]; other site
632292001854	ATP-binding site [chemical binding]; other site
632292001855	peptide chain release factor 2; Validated; Region: prfB; PRK00578
632292001856	This domain is found in peptide chain release factors; Region: PCRF; smart00937
632292001857	RF-1 domain; Region: RF-1; pfam00472
632292001858	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
632292001859	Response regulator receiver domain; Region: Response_reg; pfam00072
632292001860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292001861	active site
632292001862	phosphorylation site [posttranslational modification]
632292001863	intermolecular recognition site; other site
632292001864	dimerization interface [polypeptide binding]; other site
632292001865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632292001866	dimer interface [polypeptide binding]; other site
632292001867	phosphorylation site [posttranslational modification]
632292001868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292001869	ATP binding site [chemical binding]; other site
632292001870	Mg2+ binding site [ion binding]; other site
632292001871	G-X-G motif; other site
632292001872	Response regulator receiver domain; Region: Response_reg; pfam00072
632292001873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292001874	active site
632292001875	phosphorylation site [posttranslational modification]
632292001876	intermolecular recognition site; other site
632292001877	dimerization interface [polypeptide binding]; other site
632292001878	HDOD domain; Region: HDOD; pfam08668
632292001879	Response regulator receiver domain; Region: Response_reg; pfam00072
632292001880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292001881	active site
632292001882	phosphorylation site [posttranslational modification]
632292001883	intermolecular recognition site; other site
632292001884	dimerization interface [polypeptide binding]; other site
632292001885	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
632292001886	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
632292001887	substrate binding site [chemical binding]; other site
632292001888	ligand binding site [chemical binding]; other site
632292001889	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
632292001890	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
632292001891	substrate binding site [chemical binding]; other site
632292001892	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
632292001893	tartrate dehydrogenase; Region: TTC; TIGR02089
632292001894	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
632292001895	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632292001896	active site
632292001897	catalytic tetrad [active]
632292001898	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632292001899	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
632292001900	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
632292001901	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
632292001902	dimer interface [polypeptide binding]; other site
632292001903	ssDNA binding site [nucleotide binding]; other site
632292001904	tetramer (dimer of dimers) interface [polypeptide binding]; other site
632292001905	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
632292001906	L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160
632292001907	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
632292001908	hexamer (dimer of trimers) interface [polypeptide binding]; other site
632292001909	substrate binding site [chemical binding]; other site
632292001910	trimer interface [polypeptide binding]; other site
632292001911	Mn binding site [ion binding]; other site
632292001912	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
632292001913	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632292001914	Walker A/P-loop; other site
632292001915	ATP binding site [chemical binding]; other site
632292001916	Q-loop/lid; other site
632292001917	ABC transporter signature motif; other site
632292001918	Walker B; other site
632292001919	D-loop; other site
632292001920	H-loop/switch region; other site
632292001921	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632292001922	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632292001923	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292001924	TM-ABC transporter signature motif; other site
632292001925	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292001926	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632292001927	TM-ABC transporter signature motif; other site
632292001928	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
632292001929	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
632292001930	ligand binding site [chemical binding]; other site
632292001931	Domain of unknown function (DUF718); Region: DUF718; cl01281
632292001932	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
632292001933	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292001934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292001935	ABC-ATPase subunit interface; other site
632292001936	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292001937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292001938	dimer interface [polypeptide binding]; other site
632292001939	ABC-ATPase subunit interface; other site
632292001940	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292001941	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292001942	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
632292001943	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
632292001944	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
632292001945	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292001946	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292001947	DNA binding site [nucleotide binding]
632292001948	domain linker motif; other site
632292001949	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
632292001950	dimerization interface [polypeptide binding]; other site
632292001951	ligand binding site [chemical binding]; other site
632292001952	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292001953	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292001954	DNA binding site [nucleotide binding]
632292001955	domain linker motif; other site
632292001956	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
632292001957	ligand binding site [chemical binding]; other site
632292001958	dimerization interface [polypeptide binding]; other site
632292001959	L-fucose isomerase; Provisional; Region: fucI; PRK10991
632292001960	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
632292001961	hexamer (dimer of trimers) interface [polypeptide binding]; other site
632292001962	trimer interface [polypeptide binding]; other site
632292001963	substrate binding site [chemical binding]; other site
632292001964	Mn binding site [ion binding]; other site
632292001965	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
632292001966	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632292001967	Walker A/P-loop; other site
632292001968	ATP binding site [chemical binding]; other site
632292001969	Q-loop/lid; other site
632292001970	ABC transporter signature motif; other site
632292001971	Walker B; other site
632292001972	D-loop; other site
632292001973	H-loop/switch region; other site
632292001974	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632292001975	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292001976	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632292001977	TM-ABC transporter signature motif; other site
632292001978	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292001979	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
632292001980	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
632292001981	putative ligand binding site [chemical binding]; other site
632292001982	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
632292001983	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
632292001984	putative substrate binding site [chemical binding]; other site
632292001985	putative ATP binding site [chemical binding]; other site
632292001986	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
632292001987	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
632292001988	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
632292001989	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
632292001990	23S rRNA interface [nucleotide binding]; other site
632292001991	L3 interface [polypeptide binding]; other site
632292001992	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
632292001993	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
632292001994	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
632292001995	Nitrogen regulatory protein P-II; Region: P-II; smart00938
632292001996	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292001997	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
632292001998	DNA repair protein RadA; Provisional; Region: PRK11823
632292001999	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
632292002000	Walker A motif/ATP binding site; other site
632292002001	ATP binding site [chemical binding]; other site
632292002002	Walker B motif; other site
632292002003	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
632292002004	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
632292002005	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
632292002006	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
632292002007	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
632292002008	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
632292002009	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
632292002010	Uncharacterized conserved protein [Function unknown]; Region: COG1284
632292002011	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
632292002012	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
632292002013	transketolase; Reviewed; Region: PRK05899
632292002014	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
632292002015	TPP-binding site [chemical binding]; other site
632292002016	dimer interface [polypeptide binding]; other site
632292002017	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
632292002018	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
632292002019	PYR/PP interface [polypeptide binding]; other site
632292002020	dimer interface [polypeptide binding]; other site
632292002021	TPP binding site [chemical binding]; other site
632292002022	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
632292002023	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
632292002024	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292002025	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292002026	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292002027	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292002028	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292002029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292002030	dimer interface [polypeptide binding]; other site
632292002031	conserved gate region; other site
632292002032	putative PBP binding loops; other site
632292002033	ABC-ATPase subunit interface; other site
632292002034	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292002035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292002036	dimer interface [polypeptide binding]; other site
632292002037	conserved gate region; other site
632292002038	putative PBP binding loops; other site
632292002039	ABC-ATPase subunit interface; other site
632292002040	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292002041	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
632292002042	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
632292002043	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
632292002044	putative active site [active]
632292002045	putative catalytic site [active]
632292002046	putative alpha-glucosidase; Provisional; Region: PRK10658
632292002047	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
632292002048	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
632292002049	active site
632292002050	homotrimer interface [polypeptide binding]; other site
632292002051	catalytic site [active]
632292002052	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
632292002053	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
632292002054	MgtC family; Region: MgtC; pfam02308
632292002055	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
632292002056	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
632292002057	homodimer interface [polypeptide binding]; other site
632292002058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292002059	catalytic residue [active]
632292002060	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
632292002061	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
632292002062	active site
632292002063	dimerization interface [polypeptide binding]; other site
632292002064	metal binding site [ion binding]; metal-binding site
632292002065	Protein of unknown function (DUF1646); Region: DUF1646; pfam07854
632292002066	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
632292002067	DNA replication protein DnaC; Validated; Region: PRK06835
632292002068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292002069	Walker A motif; other site
632292002070	ATP binding site [chemical binding]; other site
632292002071	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
632292002072	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
632292002073	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
632292002074	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
632292002075	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
632292002076	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
632292002077	YacP-like NYN domain; Region: NYN_YacP; pfam05991
632292002078	RNA polymerase factor sigma-70; Validated; Region: PRK08295
632292002079	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292002080	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
632292002081	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
632292002082	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
632292002083	active site
632292002084	substrate binding site [chemical binding]; other site
632292002085	metal binding site [ion binding]; metal-binding site
632292002086	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
632292002087	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
632292002088	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
632292002089	glutamate racemase; Provisional; Region: PRK00865
632292002090	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
632292002091	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
632292002092	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
632292002093	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
632292002094	active site
632292002095	HIGH motif; other site
632292002096	KMSK motif region; other site
632292002097	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
632292002098	tRNA binding surface [nucleotide binding]; other site
632292002099	anticodon binding site; other site
632292002100	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
632292002101	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
632292002102	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
632292002103	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
632292002104	active site
632292002105	FMN binding site [chemical binding]; other site
632292002106	substrate binding site [chemical binding]; other site
632292002107	3Fe-4S cluster binding site [ion binding]; other site
632292002108	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292002109	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292002110	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292002111	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292002112	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292002113	dimer interface [polypeptide binding]; other site
632292002114	conserved gate region; other site
632292002115	ABC-ATPase subunit interface; other site
632292002116	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292002117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292002118	dimer interface [polypeptide binding]; other site
632292002119	ABC-ATPase subunit interface; other site
632292002120	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292002121	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
632292002122	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
632292002123	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
632292002124	Int/Topo IB signature motif; other site
632292002125	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632292002126	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
632292002127	FeS/SAM binding site; other site
632292002128	HIRAN domain; Region: HIRAN; pfam08797
632292002129	Domain of unknown function (DUF955); Region: DUF955; cl01076
632292002130	Homeodomain-like domain; Region: HTH_23; cl17451
632292002131	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
632292002132	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292002133	non-specific DNA binding site [nucleotide binding]; other site
632292002134	salt bridge; other site
632292002135	sequence-specific DNA binding site [nucleotide binding]; other site
632292002136	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292002137	non-specific DNA binding site [nucleotide binding]; other site
632292002138	salt bridge; other site
632292002139	sequence-specific DNA binding site [nucleotide binding]; other site
632292002140	[NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143
632292002141	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292002142	non-specific DNA binding site [nucleotide binding]; other site
632292002143	salt bridge; other site
632292002144	sequence-specific DNA binding site [nucleotide binding]; other site
632292002145	Helix-turn-helix domain; Region: HTH_17; cl17695
632292002146	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
632292002147	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
632292002148	putative active site [active]
632292002149	Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417
632292002150	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
632292002151	metal binding site [ion binding]; metal-binding site
632292002152	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
632292002153	RNA polymerase sigma factor; Provisional; Region: PRK12520
632292002154	large terminase protein; Provisional; Region: 17; PHA02533
632292002155	Terminase-like family; Region: Terminase_6; pfam03237
632292002156	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
632292002157	Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289
632292002158	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
632292002159	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
632292002160	Phage XkdN-like protein; Region: XkdN; pfam08890
632292002161	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
632292002162	Protein of unknown function (DUF3209); Region: DUF3209; pfam11483
632292002163	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632292002164	Protein of unknown function (DUF2634); Region: DUF2634; pfam10934
632292002165	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
632292002166	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
632292002167	Protein of unknown function (DUF433); Region: DUF433; cl01030
632292002168	Haemolysin XhlA; Region: XhlA; pfam10779
632292002169	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
632292002170	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
632292002171	active site
632292002172	metal binding site [ion binding]; metal-binding site
632292002173	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
632292002174	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
632292002175	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
632292002176	NAD binding site [chemical binding]; other site
632292002177	sugar binding site [chemical binding]; other site
632292002178	divalent metal binding site [ion binding]; other site
632292002179	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
632292002180	dimer interface [polypeptide binding]; other site
632292002181	replicative DNA helicase; Provisional; Region: PRK05748
632292002182	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
632292002183	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
632292002184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632292002185	non-specific DNA binding site [nucleotide binding]; other site
632292002186	salt bridge; other site
632292002187	sequence-specific DNA binding site [nucleotide binding]; other site
632292002188	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
632292002189	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632292002190	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292002191	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632292002192	putative active site [active]
632292002193	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
632292002194	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
632292002195	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
632292002196	Ferritin-like domain; Region: Ferritin; pfam00210
632292002197	ferroxidase diiron center [ion binding]; other site
632292002198	Transposase domain (DUF772); Region: DUF772; pfam05598
632292002199	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
632292002200	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
632292002201	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
632292002202	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
632292002203	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
632292002204	oligomerization interface [polypeptide binding]; other site
632292002205	active site
632292002206	metal binding site [ion binding]; metal-binding site
632292002207	pantoate--beta-alanine ligase; Region: panC; TIGR00018
632292002208	Pantoate-beta-alanine ligase; Region: PanC; cd00560
632292002209	active site
632292002210	ATP-binding site [chemical binding]; other site
632292002211	pantoate-binding site; other site
632292002212	HXXH motif; other site
632292002213	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
632292002214	tetramerization interface [polypeptide binding]; other site
632292002215	active site
632292002216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
632292002217	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
632292002218	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
632292002219	Coat F domain; Region: Coat_F; pfam07875
632292002220	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
632292002221	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632292002222	Coenzyme A binding pocket [chemical binding]; other site
632292002223	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
632292002224	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
632292002225	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
632292002226	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
632292002227	DNA interaction; other site
632292002228	Metal-binding active site; metal-binding site
632292002229	aspartate kinase; Reviewed; Region: PRK06635
632292002230	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
632292002231	putative catalytic residues [active]
632292002232	putative nucleotide binding site [chemical binding]; other site
632292002233	putative aspartate binding site [chemical binding]; other site
632292002234	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
632292002235	putative allosteric regulatory site; other site
632292002236	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
632292002237	putative allosteric regulatory residue; other site
632292002238	homoserine kinase; Provisional; Region: PRK01212
632292002239	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
632292002240	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
632292002241	homoserine dehydrogenase; Provisional; Region: PRK06349
632292002242	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
632292002243	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
632292002244	hypothetical protein; Provisional; Region: PRK04435
632292002245	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
632292002246	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
632292002247	Spore germination protein; Region: Spore_permease; cl17796
632292002248	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
632292002249	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
632292002250	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
632292002251	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292002252	active site
632292002253	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
632292002254	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292002255	Zn2+ binding site [ion binding]; other site
632292002256	Mg2+ binding site [ion binding]; other site
632292002257	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
632292002258	synthetase active site [active]
632292002259	NTP binding site [chemical binding]; other site
632292002260	metal binding site [ion binding]; metal-binding site
632292002261	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
632292002262	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
632292002263	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
632292002264	putative active site [active]
632292002265	dimerization interface [polypeptide binding]; other site
632292002266	putative tRNAtyr binding site [nucleotide binding]; other site
632292002267	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
632292002268	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
632292002269	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292002270	FeS/SAM binding site; other site
632292002271	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632292002272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292002273	FeS/SAM binding site; other site
632292002274	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
632292002275	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
632292002276	active site
632292002277	homodimer interface [polypeptide binding]; other site
632292002278	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632292002279	Interdomain contacts; other site
632292002280	Cytokine receptor motif; other site
632292002281	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632292002282	Interdomain contacts; other site
632292002283	Cytokine receptor motif; other site
632292002284	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632292002285	Interdomain contacts; other site
632292002286	Cytokine receptor motif; other site
632292002287	S-layer homology domain; Region: SLH; pfam00395
632292002288	S-layer homology domain; Region: SLH; pfam00395
632292002289	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
632292002290	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
632292002291	substrate binding pocket [chemical binding]; other site
632292002292	membrane-bound complex binding site; other site
632292002293	hinge residues; other site
632292002294	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
632292002295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292002296	dimer interface [polypeptide binding]; other site
632292002297	conserved gate region; other site
632292002298	putative PBP binding loops; other site
632292002299	ABC-ATPase subunit interface; other site
632292002300	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
632292002301	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
632292002302	Walker A/P-loop; other site
632292002303	ATP binding site [chemical binding]; other site
632292002304	Q-loop/lid; other site
632292002305	ABC transporter signature motif; other site
632292002306	Walker B; other site
632292002307	D-loop; other site
632292002308	H-loop/switch region; other site
632292002309	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
632292002310	EamA-like transporter family; Region: EamA; pfam00892
632292002311	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
632292002312	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
632292002313	Beta-Casp domain; Region: Beta-Casp; smart01027
632292002314	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
632292002315	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
632292002316	arsenical-resistance protein; Region: acr3; TIGR00832
632292002317	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
632292002318	Low molecular weight phosphatase family; Region: LMWPc; cd00115
632292002319	active site
632292002320	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292002321	dimerization interface [polypeptide binding]; other site
632292002322	putative DNA binding site [nucleotide binding]; other site
632292002323	putative Zn2+ binding site [ion binding]; other site
632292002324	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
632292002325	putative active site [active]
632292002326	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
632292002327	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
632292002328	Transposase, Mutator family; Region: Transposase_mut; pfam00872
632292002329	Transposase; Region: DEDD_Tnp_IS110; pfam01548
632292002330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
632292002331	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
632292002332	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
632292002333	Abhydrolase family; Region: Abhydrolase_7; pfam12715
632292002334	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
632292002335	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
632292002336	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
632292002337	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
632292002338	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
632292002339	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
632292002340	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292002341	FeS/SAM binding site; other site
632292002342	Helix-hairpin-helix motif; Region: HHH; pfam00633
632292002343	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
632292002344	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
632292002345	hydroxyglutarate oxidase; Provisional; Region: PRK11728
632292002346	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
632292002347	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
632292002348	active site
632292002349	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
632292002350	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
632292002351	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
632292002352	Competence protein; Region: Competence; pfam03772
632292002353	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
632292002354	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632292002355	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
632292002356	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
632292002357	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
632292002358	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
632292002359	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
632292002360	NAD binding site [chemical binding]; other site
632292002361	dimer interface [polypeptide binding]; other site
632292002362	substrate binding site [chemical binding]; other site
632292002363	tetramer (dimer of dimers) interface [polypeptide binding]; other site
632292002364	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
632292002365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292002366	dimer interface [polypeptide binding]; other site
632292002367	conserved gate region; other site
632292002368	putative PBP binding loops; other site
632292002369	ABC-ATPase subunit interface; other site
632292002370	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
632292002371	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
632292002372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292002373	dimer interface [polypeptide binding]; other site
632292002374	conserved gate region; other site
632292002375	putative PBP binding loops; other site
632292002376	ABC-ATPase subunit interface; other site
632292002377	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
632292002378	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
632292002379	Walker A/P-loop; other site
632292002380	ATP binding site [chemical binding]; other site
632292002381	Q-loop/lid; other site
632292002382	ABC transporter signature motif; other site
632292002383	Walker B; other site
632292002384	D-loop; other site
632292002385	H-loop/switch region; other site
632292002386	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
632292002387	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
632292002388	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
632292002389	peptide binding site [polypeptide binding]; other site
632292002390	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292002391	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
632292002392	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
632292002393	metal binding site [ion binding]; metal-binding site
632292002394	dimer interface [polypeptide binding]; other site
632292002395	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
632292002396	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292002397	DNA-binding site [nucleotide binding]; DNA binding site
632292002398	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632292002399	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292002400	homodimer interface [polypeptide binding]; other site
632292002401	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
632292002402	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
632292002403	active site
632292002404	multimer interface [polypeptide binding]; other site
632292002405	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
632292002406	predicted active site [active]
632292002407	catalytic triad [active]
632292002408	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
632292002409	Uncharacterized conserved protein [Function unknown]; Region: COG0062
632292002410	putative carbohydrate kinase; Provisional; Region: PRK10565
632292002411	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
632292002412	putative substrate binding site [chemical binding]; other site
632292002413	putative ATP binding site [chemical binding]; other site
632292002414	alanine racemase; Reviewed; Region: alr; PRK00053
632292002415	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
632292002416	active site
632292002417	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
632292002418	dimer interface [polypeptide binding]; other site
632292002419	substrate binding site [chemical binding]; other site
632292002420	catalytic residues [active]
632292002421	PemK-like protein; Region: PemK; pfam02452
632292002422	Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702
632292002423	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
632292002424	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
632292002425	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
632292002426	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
632292002427	catalytic residues [active]
632292002428	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
632292002429	lipoyl-biotinyl attachment site [posttranslational modification]; other site
632292002430	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
632292002431	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
632292002432	intersubunit interface [polypeptide binding]; other site
632292002433	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
632292002434	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
632292002435	ABC-ATPase subunit  interface; other site
632292002436	dimer interface [polypeptide binding]; other site
632292002437	putative PBP binding regions; other site
632292002438	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
632292002439	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
632292002440	Walker A/P-loop; other site
632292002441	ATP binding site [chemical binding]; other site
632292002442	Q-loop/lid; other site
632292002443	ABC transporter signature motif; other site
632292002444	Walker B; other site
632292002445	D-loop; other site
632292002446	H-loop/switch region; other site
632292002447	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
632292002448	Bacterial SH3 domain; Region: SH3_3; pfam08239
632292002449	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
632292002450	NlpC/P60 family; Region: NLPC_P60; pfam00877
632292002451	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
632292002452	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
632292002453	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292002454	active site
632292002455	motif I; other site
632292002456	motif II; other site
632292002457	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
632292002458	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
632292002459	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
632292002460	shikimate binding site; other site
632292002461	NAD(P) binding site [chemical binding]; other site
632292002462	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
632292002463	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
632292002464	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
632292002465	Walker A motif; other site
632292002466	ATP binding site [chemical binding]; other site
632292002467	Walker B motif; other site
632292002468	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
632292002469	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
632292002470	Walker A motif; other site
632292002471	ATP binding site [chemical binding]; other site
632292002472	Walker B motif; other site
632292002473	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
632292002474	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
632292002475	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
632292002476	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
632292002477	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
632292002478	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
632292002479	Late competence development protein ComFB; Region: ComFB; pfam10719
632292002480	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
632292002481	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
632292002482	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
632292002483	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
632292002484	Fe-S cluster binding site [ion binding]; other site
632292002485	active site
632292002486	acetylornithine aminotransferase; Provisional; Region: PRK02627
632292002487	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
632292002488	inhibitor-cofactor binding pocket; inhibition site
632292002489	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292002490	catalytic residue [active]
632292002491	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
632292002492	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
632292002493	Uncharacterized membrane protein [Function unknown]; Region: COG3949
632292002494	Bacitracin resistance protein BacA; Region: BacA; pfam02673
632292002495	UGMP family protein; Validated; Region: PRK09604
632292002496	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
632292002497	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
632292002498	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632292002499	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292002500	Zn2+ binding site [ion binding]; other site
632292002501	Mg2+ binding site [ion binding]; other site
632292002502	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
632292002503	elongation factor G; Reviewed; Region: PRK12740
632292002504	G1 box; other site
632292002505	putative GEF interaction site [polypeptide binding]; other site
632292002506	GTP/Mg2+ binding site [chemical binding]; other site
632292002507	Switch I region; other site
632292002508	G2 box; other site
632292002509	G3 box; other site
632292002510	Switch II region; other site
632292002511	G4 box; other site
632292002512	G5 box; other site
632292002513	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
632292002514	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
632292002515	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
632292002516	Probable zinc-binding domain; Region: zf-trcl; pfam13451
632292002517	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
632292002518	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
632292002519	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
632292002520	NodB motif; other site
632292002521	active site
632292002522	catalytic site [active]
632292002523	Zn binding site [ion binding]; other site
632292002524	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
632292002525	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
632292002526	UvrB/uvrC motif; Region: UVR; pfam02151
632292002527	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
632292002528	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
632292002529	ADP binding site [chemical binding]; other site
632292002530	phosphagen binding site; other site
632292002531	substrate specificity loop; other site
632292002532	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
632292002533	Clp amino terminal domain; Region: Clp_N; pfam02861
632292002534	Clp amino terminal domain; Region: Clp_N; pfam02861
632292002535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292002536	Walker A motif; other site
632292002537	ATP binding site [chemical binding]; other site
632292002538	Walker B motif; other site
632292002539	arginine finger; other site
632292002540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292002541	Walker A motif; other site
632292002542	ATP binding site [chemical binding]; other site
632292002543	Walker B motif; other site
632292002544	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
632292002545	6-phosphofructokinase; Provisional; Region: PRK14072
632292002546	active site
632292002547	ADP/pyrophosphate binding site [chemical binding]; other site
632292002548	dimerization interface [polypeptide binding]; other site
632292002549	allosteric effector site; other site
632292002550	fructose-1,6-bisphosphate binding site; other site
632292002551	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
632292002552	Domain of unknown function (DUF814); Region: DUF814; pfam05670
632292002553	O-Antigen ligase; Region: Wzy_C; cl04850
632292002554	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
632292002555	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
632292002556	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292002557	putative homodimer interface [polypeptide binding]; other site
632292002558	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
632292002559	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
632292002560	NAD(P) binding site [chemical binding]; other site
632292002561	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
632292002562	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
632292002563	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
632292002564	rRNA interaction site [nucleotide binding]; other site
632292002565	S8 interaction site; other site
632292002566	putative laminin-1 binding site; other site
632292002567	elongation factor Ts; Reviewed; Region: tsf; PRK12332
632292002568	UBA/TS-N domain; Region: UBA; pfam00627
632292002569	Elongation factor TS; Region: EF_TS; pfam00889
632292002570	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
632292002571	putative nucleotide binding site [chemical binding]; other site
632292002572	uridine monophosphate binding site [chemical binding]; other site
632292002573	homohexameric interface [polypeptide binding]; other site
632292002574	ribosome recycling factor; Reviewed; Region: frr; PRK00083
632292002575	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
632292002576	hinge region; other site
632292002577	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
632292002578	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
632292002579	catalytic residue [active]
632292002580	putative FPP diphosphate  binding site; other site
632292002581	putative FPP binding hydrophobic cleft; other site
632292002582	dimer interface [polypeptide binding]; other site
632292002583	putative IPP diphosphate binding site; other site
632292002584	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
632292002585	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
632292002586	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
632292002587	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
632292002588	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
632292002589	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
632292002590	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
632292002591	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
632292002592	active site
632292002593	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
632292002594	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
632292002595	putative substrate binding region [chemical binding]; other site
632292002596	GcpE protein; Region: GcpE; pfam04551
632292002597	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
632292002598	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
632292002599	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
632292002600	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
632292002601	Ligand binding site; other site
632292002602	Putative Catalytic site; other site
632292002603	DXD motif; other site
632292002604	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
632292002605	DNA polymerase III PolC; Validated; Region: polC; PRK00448
632292002606	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
632292002607	generic binding surface II; other site
632292002608	generic binding surface I; other site
632292002609	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632292002610	active site
632292002611	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
632292002612	active site
632292002613	catalytic site [active]
632292002614	substrate binding site [chemical binding]; other site
632292002615	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
632292002616	Thiamine pyrophosphokinase; Region: TPK; cd07995
632292002617	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
632292002618	active site
632292002619	dimerization interface [polypeptide binding]; other site
632292002620	thiamine binding site [chemical binding]; other site
632292002621	Predicted membrane protein [Function unknown]; Region: COG2261
632292002622	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
632292002623	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
632292002624	Walker A/P-loop; other site
632292002625	ATP binding site [chemical binding]; other site
632292002626	Q-loop/lid; other site
632292002627	ABC transporter signature motif; other site
632292002628	Walker B; other site
632292002629	D-loop; other site
632292002630	H-loop/switch region; other site
632292002631	TOBE domain; Region: TOBE; pfam03459
632292002632	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
632292002633	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
632292002634	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
632292002635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292002636	Walker A/P-loop; other site
632292002637	ATP binding site [chemical binding]; other site
632292002638	Q-loop/lid; other site
632292002639	ABC transporter signature motif; other site
632292002640	Walker B; other site
632292002641	D-loop; other site
632292002642	H-loop/switch region; other site
632292002643	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
632292002644	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
632292002645	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
632292002646	Peptidase family M23; Region: Peptidase_M23; pfam01551
632292002647	C-terminal peptidase (prc); Region: prc; TIGR00225
632292002648	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
632292002649	protein binding site [polypeptide binding]; other site
632292002650	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
632292002651	Catalytic dyad [active]
632292002652	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
632292002653	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
632292002654	Peptidase family M23; Region: Peptidase_M23; pfam01551
632292002655	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
632292002656	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
632292002657	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
632292002658	germination protein YpeB; Region: spore_YpeB; TIGR02889
632292002659	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
632292002660	germination protease; Provisional; Region: PRK12362
632292002661	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
632292002662	stage II sporulation protein P; Region: spore_II_P; TIGR02867
632292002663	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
632292002664	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
632292002665	active site
632292002666	Int/Topo IB signature motif; other site
632292002667	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632292002668	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
632292002669	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
632292002670	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
632292002671	catalytic triad [active]
632292002672	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
632292002673	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
632292002674	ligand binding site [chemical binding]; other site
632292002675	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
632292002676	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
632292002677	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632292002678	Walker A/P-loop; other site
632292002679	ATP binding site [chemical binding]; other site
632292002680	Q-loop/lid; other site
632292002681	ABC transporter signature motif; other site
632292002682	Walker B; other site
632292002683	D-loop; other site
632292002684	H-loop/switch region; other site
632292002685	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632292002686	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292002687	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
632292002688	TM-ABC transporter signature motif; other site
632292002689	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292002690	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
632292002691	TM-ABC transporter signature motif; other site
632292002692	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
632292002693	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292002694	DNA-binding site [nucleotide binding]; DNA binding site
632292002695	UTRA domain; Region: UTRA; pfam07702
632292002696	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
632292002697	active site
632292002698	catalytic motif [active]
632292002699	Zn binding site [ion binding]; other site
632292002700	XapX domain; Region: XapX; TIGR03510
632292002701	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
632292002702	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
632292002703	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
632292002704	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
632292002705	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
632292002706	intersubunit interface [polypeptide binding]; other site
632292002707	active site
632292002708	catalytic residue [active]
632292002709	phosphopentomutase; Provisional; Region: PRK05362
632292002710	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
632292002711	purine nucleoside phosphorylase; Provisional; Region: PRK08202
632292002712	Response regulator receiver domain; Region: Response_reg; pfam00072
632292002713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292002714	active site
632292002715	phosphorylation site [posttranslational modification]
632292002716	intermolecular recognition site; other site
632292002717	dimerization interface [polypeptide binding]; other site
632292002718	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
632292002719	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
632292002720	putative binding surface; other site
632292002721	active site
632292002722	P2 response regulator binding domain; Region: P2; pfam07194
632292002723	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
632292002724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292002725	ATP binding site [chemical binding]; other site
632292002726	Mg2+ binding site [ion binding]; other site
632292002727	G-X-G motif; other site
632292002728	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
632292002729	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
632292002730	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
632292002731	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
632292002732	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292002733	dimerization interface [polypeptide binding]; other site
632292002734	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292002735	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292002736	dimer interface [polypeptide binding]; other site
632292002737	putative CheW interface [polypeptide binding]; other site
632292002738	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
632292002739	YtxC-like family; Region: YtxC; pfam08812
632292002740	Trp repressor protein; Region: Trp_repressor; cl17266
632292002741	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
632292002742	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
632292002743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
632292002744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292002745	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
632292002746	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
632292002747	protein binding site [polypeptide binding]; other site
632292002748	4Fe-4S binding domain; Region: Fer4; pfam00037
632292002749	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
632292002750	putative homodimer interface [polypeptide binding]; other site
632292002751	putative homotetramer interface [polypeptide binding]; other site
632292002752	putative allosteric switch controlling residues; other site
632292002753	putative metal binding site [ion binding]; other site
632292002754	putative homodimer-homodimer interface [polypeptide binding]; other site
632292002755	B12 binding domain; Region: B12-binding; pfam02310
632292002756	B12 binding site [chemical binding]; other site
632292002757	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
632292002758	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292002759	FeS/SAM binding site; other site
632292002760	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
632292002761	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
632292002762	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
632292002763	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
632292002764	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
632292002765	oligomer interface [polypeptide binding]; other site
632292002766	putative active site [active]
632292002767	metal binding site [ion binding]; metal-binding site
632292002768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292002769	H+ Antiporter protein; Region: 2A0121; TIGR00900
632292002770	putative substrate translocation pore; other site
632292002771	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
632292002772	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
632292002773	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
632292002774	active site
632292002775	substrate binding site [chemical binding]; other site
632292002776	metal binding site [ion binding]; metal-binding site
632292002777	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632292002778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292002779	active site
632292002780	phosphorylation site [posttranslational modification]
632292002781	intermolecular recognition site; other site
632292002782	dimerization interface [polypeptide binding]; other site
632292002783	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632292002784	DNA binding site [nucleotide binding]
632292002785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632292002786	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292002787	dimerization interface [polypeptide binding]; other site
632292002788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632292002789	dimer interface [polypeptide binding]; other site
632292002790	phosphorylation site [posttranslational modification]
632292002791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292002792	ATP binding site [chemical binding]; other site
632292002793	Mg2+ binding site [ion binding]; other site
632292002794	G-X-G motif; other site
632292002795	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292002796	Zn2+ binding site [ion binding]; other site
632292002797	Mg2+ binding site [ion binding]; other site
632292002798	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632292002799	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292002800	Zn2+ binding site [ion binding]; other site
632292002801	Mg2+ binding site [ion binding]; other site
632292002802	Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908
632292002803	Ferritin-like domain; Region: Ferritin; pfam00210
632292002804	dinuclear metal binding motif [ion binding]; other site
632292002805	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
632292002806	iron binding site [ion binding]; other site
632292002807	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
632292002808	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
632292002809	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
632292002810	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
632292002811	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
632292002812	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
632292002813	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
632292002814	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
632292002815	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
632292002816	putative translocon binding site; other site
632292002817	protein-rRNA interface [nucleotide binding]; other site
632292002818	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
632292002819	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
632292002820	G-X-X-G motif; other site
632292002821	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
632292002822	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
632292002823	23S rRNA interface [nucleotide binding]; other site
632292002824	5S rRNA interface [nucleotide binding]; other site
632292002825	putative antibiotic binding site [chemical binding]; other site
632292002826	L25 interface [polypeptide binding]; other site
632292002827	L27 interface [polypeptide binding]; other site
632292002828	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
632292002829	23S rRNA interface [nucleotide binding]; other site
632292002830	putative translocon interaction site; other site
632292002831	signal recognition particle (SRP54) interaction site; other site
632292002832	L23 interface [polypeptide binding]; other site
632292002833	trigger factor interaction site; other site
632292002834	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
632292002835	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
632292002836	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
632292002837	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
632292002838	RNA binding site [nucleotide binding]; other site
632292002839	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
632292002840	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
632292002841	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
632292002842	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
632292002843	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
632292002844	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
632292002845	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
632292002846	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
632292002847	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
632292002848	23S rRNA interface [nucleotide binding]; other site
632292002849	5S rRNA interface [nucleotide binding]; other site
632292002850	L27 interface [polypeptide binding]; other site
632292002851	L5 interface [polypeptide binding]; other site
632292002852	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
632292002853	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
632292002854	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
632292002855	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
632292002856	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
632292002857	SecY translocase; Region: SecY; pfam00344
632292002858	adenylate kinase; Reviewed; Region: adk; PRK00279
632292002859	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
632292002860	AMP-binding site [chemical binding]; other site
632292002861	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
632292002862	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
632292002863	active site
632292002864	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
632292002865	RNA binding site [nucleotide binding]; other site
632292002866	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
632292002867	rRNA binding site [nucleotide binding]; other site
632292002868	predicted 30S ribosome binding site; other site
632292002869	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
632292002870	30S ribosomal protein S13; Region: bact_S13; TIGR03631
632292002871	30S ribosomal protein S11; Validated; Region: PRK05309
632292002872	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
632292002873	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
632292002874	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632292002875	RNA binding surface [nucleotide binding]; other site
632292002876	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
632292002877	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
632292002878	alphaNTD homodimer interface [polypeptide binding]; other site
632292002879	alphaNTD - beta interaction site [polypeptide binding]; other site
632292002880	alphaNTD - beta' interaction site [polypeptide binding]; other site
632292002881	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
632292002882	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
632292002883	Transcriptional regulator; Region: Rrf2; cl17282
632292002884	Rrf2 family protein; Region: rrf2_super; TIGR00738
632292002885	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
632292002886	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
632292002887	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
632292002888	catalytic residue [active]
632292002889	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
632292002890	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
632292002891	trimerization site [polypeptide binding]; other site
632292002892	active site
632292002893	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
632292002894	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
632292002895	Ligand Binding Site [chemical binding]; other site
632292002896	histidinol-phosphatase; Provisional; Region: PRK05588
632292002897	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632292002898	active site
632292002899	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
632292002900	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
632292002901	active site
632292002902	NTP binding site [chemical binding]; other site
632292002903	metal binding triad [ion binding]; metal-binding site
632292002904	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
632292002905	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
632292002906	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
632292002907	pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028
632292002908	4Fe-4S binding domain; Region: Fer4_6; pfam12837
632292002909	4Fe-4S binding domain; Region: Fer4; pfam00037
632292002910	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
632292002911	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
632292002912	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632292002913	dimer interface [polypeptide binding]; other site
632292002914	PYR/PP interface [polypeptide binding]; other site
632292002915	TPP binding site [chemical binding]; other site
632292002916	substrate binding site [chemical binding]; other site
632292002917	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
632292002918	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
632292002919	TPP-binding site [chemical binding]; other site
632292002920	putative dimer interface [polypeptide binding]; other site
632292002921	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632292002922	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632292002923	Walker A/P-loop; other site
632292002924	ATP binding site [chemical binding]; other site
632292002925	Q-loop/lid; other site
632292002926	ABC transporter signature motif; other site
632292002927	Walker B; other site
632292002928	D-loop; other site
632292002929	H-loop/switch region; other site
632292002930	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
632292002931	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
632292002932	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
632292002933	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292002934	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292002935	DNA binding residues [nucleotide binding]
632292002936	shikimate kinase; Reviewed; Region: aroK; PRK00131
632292002937	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
632292002938	ADP binding site [chemical binding]; other site
632292002939	magnesium binding site [ion binding]; other site
632292002940	putative shikimate binding site; other site
632292002941	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
632292002942	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
632292002943	Metal-binding active site; metal-binding site
632292002944	AP (apurinic/apyrimidinic) site pocket; other site
632292002945	Dehydroquinase class II; Region: DHquinase_II; pfam01220
632292002946	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
632292002947	trimer interface [polypeptide binding]; other site
632292002948	active site
632292002949	dimer interface [polypeptide binding]; other site
632292002950	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
632292002951	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
632292002952	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
632292002953	active site
632292002954	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
632292002955	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
632292002956	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
632292002957	Glutamine amidotransferase class-I; Region: GATase; pfam00117
632292002958	glutamine binding [chemical binding]; other site
632292002959	catalytic triad [active]
632292002960	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
632292002961	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
632292002962	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
632292002963	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
632292002964	active site
632292002965	ribulose/triose binding site [chemical binding]; other site
632292002966	phosphate binding site [ion binding]; other site
632292002967	substrate (anthranilate) binding pocket [chemical binding]; other site
632292002968	product (indole) binding pocket [chemical binding]; other site
632292002969	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
632292002970	active site
632292002971	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
632292002972	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
632292002973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292002974	catalytic residue [active]
632292002975	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
632292002976	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
632292002977	substrate binding site [chemical binding]; other site
632292002978	active site
632292002979	catalytic residues [active]
632292002980	heterodimer interface [polypeptide binding]; other site
632292002981	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
632292002982	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
632292002983	Walker A/P-loop; other site
632292002984	ATP binding site [chemical binding]; other site
632292002985	Q-loop/lid; other site
632292002986	ABC transporter signature motif; other site
632292002987	Walker B; other site
632292002988	D-loop; other site
632292002989	H-loop/switch region; other site
632292002990	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
632292002991	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
632292002992	Walker A/P-loop; other site
632292002993	ATP binding site [chemical binding]; other site
632292002994	Q-loop/lid; other site
632292002995	ABC transporter signature motif; other site
632292002996	Walker B; other site
632292002997	D-loop; other site
632292002998	H-loop/switch region; other site
632292002999	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
632292003000	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
632292003001	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
632292003002	dimerization interface 3.5A [polypeptide binding]; other site
632292003003	active site
632292003004	Uncharacterized conserved protein [Function unknown]; Region: COG1434
632292003005	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
632292003006	putative active site [active]
632292003007	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
632292003008	anti sigma factor interaction site; other site
632292003009	regulatory phosphorylation site [posttranslational modification]; other site
632292003010	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
632292003011	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
632292003012	ATP binding site [chemical binding]; other site
632292003013	Mg2+ binding site [ion binding]; other site
632292003014	G-X-G motif; other site
632292003015	sporulation sigma factor SigF; Validated; Region: PRK05572
632292003016	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292003017	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
632292003018	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292003019	DNA binding residues [nucleotide binding]
632292003020	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
632292003021	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292003022	active site
632292003023	flagellar operon protein TIGR03826; Region: YvyF
632292003024	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
632292003025	FlgN protein; Region: FlgN; pfam05130
632292003026	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
632292003027	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
632292003028	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
632292003029	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
632292003030	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
632292003031	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632292003032	active site
632292003033	NTP binding site [chemical binding]; other site
632292003034	metal binding triad [ion binding]; metal-binding site
632292003035	antibiotic binding site [chemical binding]; other site
632292003036	Uncharacterized conserved protein [Function unknown]; Region: COG2445
632292003037	flagellar assembly protein FliW; Provisional; Region: PRK13285
632292003038	Global regulator protein family; Region: CsrA; pfam02599
632292003039	flagellin; Provisional; Region: PRK12804
632292003040	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
632292003041	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
632292003042	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
632292003043	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
632292003044	putative metal binding site; other site
632292003045	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632292003046	binding surface
632292003047	TPR motif; other site
632292003048	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632292003049	binding surface
632292003050	TPR motif; other site
632292003051	TPR repeat; Region: TPR_11; pfam13414
632292003052	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292003053	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
632292003054	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
632292003055	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
632292003056	active site
632292003057	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292003058	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
632292003059	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
632292003060	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
632292003061	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
632292003062	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
632292003063	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
632292003064	substrate binding site; other site
632292003065	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
632292003066	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
632292003067	NAD binding site [chemical binding]; other site
632292003068	homotetramer interface [polypeptide binding]; other site
632292003069	homodimer interface [polypeptide binding]; other site
632292003070	substrate binding site [chemical binding]; other site
632292003071	active site
632292003072	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
632292003073	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
632292003074	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292003075	ATP binding site [chemical binding]; other site
632292003076	putative Mg++ binding site [ion binding]; other site
632292003077	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632292003078	nucleotide binding region [chemical binding]; other site
632292003079	ATP-binding site [chemical binding]; other site
632292003080	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
632292003081	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
632292003082	ligand binding site [chemical binding]; other site
632292003083	FlaG protein; Region: FlaG; pfam03646
632292003084	flagellar capping protein; Validated; Region: fliD; PRK07737
632292003085	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
632292003086	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
632292003087	Flagellar protein FliS; Region: FliS; cl00654
632292003088	FlgN protein; Region: FlgN; pfam05130
632292003089	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
632292003090	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632292003091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292003092	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
632292003093	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
632292003094	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
632292003095	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
632292003096	gamma-glutamyl kinase; Provisional; Region: PRK05429
632292003097	nucleotide binding site [chemical binding]; other site
632292003098	homotetrameric interface [polypeptide binding]; other site
632292003099	putative phosphate binding site [ion binding]; other site
632292003100	putative allosteric binding site; other site
632292003101	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
632292003102	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
632292003103	putative catalytic cysteine [active]
632292003104	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
632292003105	MutS domain III; Region: MutS_III; pfam05192
632292003106	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
632292003107	Walker A/P-loop; other site
632292003108	ATP binding site [chemical binding]; other site
632292003109	Q-loop/lid; other site
632292003110	ABC transporter signature motif; other site
632292003111	Walker B; other site
632292003112	D-loop; other site
632292003113	H-loop/switch region; other site
632292003114	Smr domain; Region: Smr; pfam01713
632292003115	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
632292003116	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
632292003117	Catalytic site [active]
632292003118	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
632292003119	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
632292003120	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
632292003121	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
632292003122	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
632292003123	active site
632292003124	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
632292003125	active site
632292003126	catalytic residues [active]
632292003127	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
632292003128	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
632292003129	Ligand Binding Site [chemical binding]; other site
632292003130	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
632292003131	AIR carboxylase; Region: AIRC; smart01001
632292003132	GTP-binding protein YchF; Reviewed; Region: PRK09601
632292003133	YchF GTPase; Region: YchF; cd01900
632292003134	G1 box; other site
632292003135	GTP/Mg2+ binding site [chemical binding]; other site
632292003136	Switch I region; other site
632292003137	G2 box; other site
632292003138	Switch II region; other site
632292003139	G3 box; other site
632292003140	G4 box; other site
632292003141	G5 box; other site
632292003142	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
632292003143	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
632292003144	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
632292003145	N-acetyl-D-glucosamine binding site [chemical binding]; other site
632292003146	catalytic residue [active]
632292003147	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
632292003148	Heme NO binding; Region: HNOB; pfam07700
632292003149	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632292003150	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292003151	dimer interface [polypeptide binding]; other site
632292003152	putative CheW interface [polypeptide binding]; other site
632292003153	Predicted membrane protein [Function unknown]; Region: COG2510
632292003154	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
632292003155	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292003156	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292003157	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292003158	Uncharacterized conserved protein [Function unknown]; Region: COG2968
632292003159	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
632292003160	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
632292003161	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
632292003162	catalytic residues [active]
632292003163	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
632292003164	putative homodimer interface [polypeptide binding]; other site
632292003165	putative homotetramer interface [polypeptide binding]; other site
632292003166	putative allosteric switch controlling residues; other site
632292003167	putative metal binding site [ion binding]; other site
632292003168	putative homodimer-homodimer interface [polypeptide binding]; other site
632292003169	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292003170	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
632292003171	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
632292003172	Family of unknown function (DUF633); Region: DUF633; pfam04816
632292003173	Uncharacterized conserved protein [Function unknown]; Region: COG0327
632292003174	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
632292003175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
632292003176	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
632292003177	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
632292003178	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
632292003179	nucleotide binding pocket [chemical binding]; other site
632292003180	K-X-D-G motif; other site
632292003181	catalytic site [active]
632292003182	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
632292003183	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
632292003184	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
632292003185	Dimer interface [polypeptide binding]; other site
632292003186	BRCT sequence motif; other site
632292003187	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
632292003188	ABC1 family; Region: ABC1; cl17513
632292003189	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
632292003190	active site
632292003191	ATP binding site [chemical binding]; other site
632292003192	Uncharacterized conserved protein [Function unknown]; Region: COG3937
632292003193	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
632292003194	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
632292003195	dimer interface [polypeptide binding]; other site
632292003196	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292003197	catalytic residue [active]
632292003198	probable regulatory domain; Region: near_KaiC_dom; TIGR03879
632292003199	KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878
632292003200	KaiC; Region: KaiC; pfam06745
632292003201	Walker A motif; other site
632292003202	ATP binding site [chemical binding]; other site
632292003203	Walker B motif; other site
632292003204	Peptidase family M48; Region: Peptidase_M48; cl12018
632292003205	Nuclease-related domain; Region: NERD; pfam08378
632292003206	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
632292003207	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
632292003208	AAA ATPase domain; Region: AAA_15; pfam13175
632292003209	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
632292003210	putative active site [active]
632292003211	putative metal-binding site [ion binding]; other site
632292003212	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
632292003213	Part of AAA domain; Region: AAA_19; pfam13245
632292003214	Family description; Region: UvrD_C_2; pfam13538
632292003215	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
632292003216	Protein of unknown function (DUF499); Region: DUF499; pfam04465
632292003217	Fn3 associated; Region: Fn3_assoc; pfam13287
632292003218	Protein of unknown function (DUF3780); Region: DUF3780; pfam12635
632292003219	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
632292003220	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
632292003221	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
632292003222	PLD-like domain; Region: PLDc_2; pfam13091
632292003223	putative active site [active]
632292003224	catalytic site [active]
632292003225	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292003226	ATP binding site [chemical binding]; other site
632292003227	putative Mg++ binding site [ion binding]; other site
632292003228	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632292003229	nucleotide binding region [chemical binding]; other site
632292003230	Uncharacterized conserved protein [Function unknown]; Region: COG1479
632292003231	Protein of unknown function DUF262; Region: DUF262; pfam03235
632292003232	Uncharacterized conserved protein [Function unknown]; Region: COG3472
632292003233	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
632292003234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292003235	Walker A motif; other site
632292003236	ATP binding site [chemical binding]; other site
632292003237	Walker B motif; other site
632292003238	SurA N-terminal domain; Region: SurA_N_3; cl07813
632292003239	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
632292003240	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
632292003241	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632292003242	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
632292003243	Walker A/P-loop; other site
632292003244	ATP binding site [chemical binding]; other site
632292003245	Q-loop/lid; other site
632292003246	ABC transporter signature motif; other site
632292003247	Walker B; other site
632292003248	D-loop; other site
632292003249	H-loop/switch region; other site
632292003250	FtsX-like permease family; Region: FtsX; pfam02687
632292003251	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
632292003252	FtsX-like permease family; Region: FtsX; pfam02687
632292003253	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
632292003254	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632292003255	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632292003256	Walker A/P-loop; other site
632292003257	ATP binding site [chemical binding]; other site
632292003258	Q-loop/lid; other site
632292003259	ABC transporter signature motif; other site
632292003260	Walker B; other site
632292003261	D-loop; other site
632292003262	H-loop/switch region; other site
632292003263	Putative zinc-finger; Region: zf-HC2; pfam13490
632292003264	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
632292003265	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292003266	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292003267	DNA binding residues [nucleotide binding]
632292003268	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
632292003269	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
632292003270	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
632292003271	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
632292003272	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632292003273	Probable transposase; Region: OrfB_IS605; pfam01385
632292003274	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632292003275	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
632292003276	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
632292003277	Flavin Reductases; Region: FlaRed; cl00801
632292003278	oligoendopeptidase F; Region: pepF; TIGR00181
632292003279	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
632292003280	active site
632292003281	Zn binding site [ion binding]; other site
632292003282	FeoA domain; Region: FeoA; pfam04023
632292003283	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
632292003284	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
632292003285	G1 box; other site
632292003286	GTP/Mg2+ binding site [chemical binding]; other site
632292003287	Switch I region; other site
632292003288	G2 box; other site
632292003289	G3 box; other site
632292003290	Switch II region; other site
632292003291	G4 box; other site
632292003292	G5 box; other site
632292003293	Nucleoside recognition; Region: Gate; pfam07670
632292003294	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
632292003295	Nucleoside recognition; Region: Gate; pfam07670
632292003296	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
632292003297	metal binding site 2 [ion binding]; metal-binding site
632292003298	putative DNA binding helix; other site
632292003299	metal binding site 1 [ion binding]; metal-binding site
632292003300	dimer interface [polypeptide binding]; other site
632292003301	structural Zn2+ binding site [ion binding]; other site
632292003302	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
632292003303	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
632292003304	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
632292003305	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
632292003306	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
632292003307	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
632292003308	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
632292003309	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292003310	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
632292003311	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
632292003312	active site
632292003313	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
632292003314	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
632292003315	putative active site [active]
632292003316	putative metal binding site [ion binding]; other site
632292003317	GTP-binding protein LepA; Provisional; Region: PRK05433
632292003318	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
632292003319	G1 box; other site
632292003320	putative GEF interaction site [polypeptide binding]; other site
632292003321	GTP/Mg2+ binding site [chemical binding]; other site
632292003322	Switch I region; other site
632292003323	G2 box; other site
632292003324	G3 box; other site
632292003325	Switch II region; other site
632292003326	G4 box; other site
632292003327	G5 box; other site
632292003328	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
632292003329	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
632292003330	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
632292003331	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
632292003332	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292003333	FeS/SAM binding site; other site
632292003334	HemN C-terminal domain; Region: HemN_C; pfam06969
632292003335	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
632292003336	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
632292003337	clostripain; Region: clostrip; TIGR02806
632292003338	heat shock protein GrpE; Provisional; Region: PRK14140
632292003339	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
632292003340	dimer interface [polypeptide binding]; other site
632292003341	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
632292003342	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
632292003343	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
632292003344	nucleotide binding site [chemical binding]; other site
632292003345	NEF interaction site [polypeptide binding]; other site
632292003346	SBD interface [polypeptide binding]; other site
632292003347	Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811
632292003348	chaperone protein DnaJ; Provisional; Region: PRK14277
632292003349	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
632292003350	HSP70 interaction site [polypeptide binding]; other site
632292003351	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
632292003352	substrate binding site [polypeptide binding]; other site
632292003353	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
632292003354	Zn binding sites [ion binding]; other site
632292003355	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
632292003356	dimer interface [polypeptide binding]; other site
632292003357	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
632292003358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292003359	S-adenosylmethionine binding site [chemical binding]; other site
632292003360	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
632292003361	RNA methyltransferase, RsmE family; Region: TIGR00046
632292003362	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
632292003363	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
632292003364	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
632292003365	catalytic residue [active]
632292003366	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
632292003367	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
632292003368	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
632292003369	Ligand Binding Site [chemical binding]; other site
632292003370	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632292003371	RNA binding surface [nucleotide binding]; other site
632292003372	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
632292003373	pseudouridine synthase; Region: TIGR00093
632292003374	active site
632292003375	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
632292003376	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
632292003377	ornithine carbamoyltransferase; Provisional; Region: PRK00779
632292003378	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
632292003379	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
632292003380	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
632292003381	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
632292003382	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
632292003383	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
632292003384	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
632292003385	ATP-grasp domain; Region: ATP-grasp_4; cl17255
632292003386	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
632292003387	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
632292003388	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
632292003389	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
632292003390	catalytic site [active]
632292003391	subunit interface [polypeptide binding]; other site
632292003392	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
632292003393	active site
632292003394	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
632292003395	dimer interface [polypeptide binding]; other site
632292003396	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
632292003397	Ligand Binding Site [chemical binding]; other site
632292003398	Molecular Tunnel; other site
632292003399	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
632292003400	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
632292003401	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
632292003402	Transcriptional regulators [Transcription]; Region: GntR; COG1802
632292003403	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292003404	DNA-binding site [nucleotide binding]; DNA binding site
632292003405	FCD domain; Region: FCD; pfam07729
632292003406	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
632292003407	active site
632292003408	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
632292003409	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
632292003410	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
632292003411	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
632292003412	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
632292003413	putative homodimer interface [polypeptide binding]; other site
632292003414	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
632292003415	heterodimer interface [polypeptide binding]; other site
632292003416	homodimer interface [polypeptide binding]; other site
632292003417	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
632292003418	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
632292003419	23S rRNA interface [nucleotide binding]; other site
632292003420	L7/L12 interface [polypeptide binding]; other site
632292003421	putative thiostrepton binding site; other site
632292003422	L25 interface [polypeptide binding]; other site
632292003423	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
632292003424	mRNA/rRNA interface [nucleotide binding]; other site
632292003425	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
632292003426	23S rRNA interface [nucleotide binding]; other site
632292003427	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
632292003428	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
632292003429	core dimer interface [polypeptide binding]; other site
632292003430	peripheral dimer interface [polypeptide binding]; other site
632292003431	L10 interface [polypeptide binding]; other site
632292003432	L11 interface [polypeptide binding]; other site
632292003433	putative EF-Tu interaction site [polypeptide binding]; other site
632292003434	putative EF-G interaction site [polypeptide binding]; other site
632292003435	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632292003436	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292003437	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
632292003438	Walker A/P-loop; other site
632292003439	ATP binding site [chemical binding]; other site
632292003440	Q-loop/lid; other site
632292003441	ABC transporter signature motif; other site
632292003442	Walker B; other site
632292003443	D-loop; other site
632292003444	H-loop/switch region; other site
632292003445	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632292003446	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292003447	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292003448	Walker A/P-loop; other site
632292003449	ATP binding site [chemical binding]; other site
632292003450	Q-loop/lid; other site
632292003451	ABC transporter signature motif; other site
632292003452	Walker B; other site
632292003453	D-loop; other site
632292003454	H-loop/switch region; other site
632292003455	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
632292003456	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
632292003457	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
632292003458	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
632292003459	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292003460	motif II; other site
632292003461	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
632292003462	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
632292003463	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
632292003464	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632292003465	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
632292003466	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
632292003467	active site residue [active]
632292003468	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
632292003469	substrate binding site; other site
632292003470	dimer interface; other site
632292003471	Isopentenyl transferase; Region: IPT; pfam01745
632292003472	Asp23 family; Region: Asp23; cl00574
632292003473	AAA domain; Region: AAA_32; pfam13654
632292003474	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
632292003475	RNA helicase; Region: RNA_helicase; pfam00910
632292003476	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
632292003477	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
632292003478	putative FMN binding site [chemical binding]; other site
632292003479	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
632292003480	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
632292003481	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
632292003482	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
632292003483	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
632292003484	HlyD family secretion protein; Region: HlyD_3; pfam13437
632292003485	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
632292003486	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632292003487	Walker A/P-loop; other site
632292003488	ATP binding site [chemical binding]; other site
632292003489	Q-loop/lid; other site
632292003490	ABC transporter signature motif; other site
632292003491	Walker B; other site
632292003492	D-loop; other site
632292003493	H-loop/switch region; other site
632292003494	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
632292003495	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
632292003496	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
632292003497	GAF domain; Region: GAF_3; pfam13492
632292003498	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632292003499	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632292003500	metal binding site [ion binding]; metal-binding site
632292003501	active site
632292003502	I-site; other site
632292003503	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
632292003504	ATP cone domain; Region: ATP-cone; pfam03477
632292003505	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
632292003506	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
632292003507	putative dimer interface [polypeptide binding]; other site
632292003508	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
632292003509	Clp amino terminal domain; Region: Clp_N; pfam02861
632292003510	Clp amino terminal domain; Region: Clp_N; pfam02861
632292003511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292003512	Walker A motif; other site
632292003513	ATP binding site [chemical binding]; other site
632292003514	Walker B motif; other site
632292003515	arginine finger; other site
632292003516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292003517	Walker A motif; other site
632292003518	ATP binding site [chemical binding]; other site
632292003519	Walker B motif; other site
632292003520	arginine finger; other site
632292003521	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
632292003522	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
632292003523	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
632292003524	acyl-activating enzyme (AAE) consensus motif; other site
632292003525	AMP binding site [chemical binding]; other site
632292003526	active site
632292003527	CoA binding site [chemical binding]; other site
632292003528	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
632292003529	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632292003530	dimer interface [polypeptide binding]; other site
632292003531	PYR/PP interface [polypeptide binding]; other site
632292003532	TPP binding site [chemical binding]; other site
632292003533	substrate binding site [chemical binding]; other site
632292003534	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
632292003535	TPP-binding site; other site
632292003536	4Fe-4S binding domain; Region: Fer4; pfam00037
632292003537	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
632292003538	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
632292003539	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
632292003540	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
632292003541	acyl-activating enzyme (AAE) consensus motif; other site
632292003542	AMP binding site [chemical binding]; other site
632292003543	active site
632292003544	CoA binding site [chemical binding]; other site
632292003545	ACT domain-containing protein [General function prediction only]; Region: COG4747
632292003546	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
632292003547	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
632292003548	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
632292003549	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
632292003550	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
632292003551	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292003552	FeS/SAM binding site; other site
632292003553	TRAM domain; Region: TRAM; pfam01938
632292003554	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
632292003555	MutS domain I; Region: MutS_I; pfam01624
632292003556	MutS domain II; Region: MutS_II; pfam05188
632292003557	MutS domain III; Region: MutS_III; pfam05192
632292003558	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
632292003559	Walker A/P-loop; other site
632292003560	ATP binding site [chemical binding]; other site
632292003561	Q-loop/lid; other site
632292003562	ABC transporter signature motif; other site
632292003563	Walker B; other site
632292003564	D-loop; other site
632292003565	H-loop/switch region; other site
632292003566	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
632292003567	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292003568	ATP binding site [chemical binding]; other site
632292003569	Mg2+ binding site [ion binding]; other site
632292003570	G-X-G motif; other site
632292003571	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
632292003572	ATP binding site [chemical binding]; other site
632292003573	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
632292003574	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
632292003575	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
632292003576	bacterial Hfq-like; Region: Hfq; cd01716
632292003577	hexamer interface [polypeptide binding]; other site
632292003578	Sm1 motif; other site
632292003579	RNA binding site [nucleotide binding]; other site
632292003580	Sm2 motif; other site
632292003581	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
632292003582	Aluminium resistance protein; Region: Alum_res; pfam06838
632292003583	LexA repressor; Validated; Region: PRK00215
632292003584	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
632292003585	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
632292003586	Catalytic site [active]
632292003587	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
632292003588	propionate/acetate kinase; Provisional; Region: PRK12379
632292003589	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
632292003590	nucleotide binding site [chemical binding]; other site
632292003591	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
632292003592	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
632292003593	non-heme iron binding site [ion binding]; other site
632292003594	dimer interface [polypeptide binding]; other site
632292003595	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
632292003596	non-heme iron binding site [ion binding]; other site
632292003597	dimer interface [polypeptide binding]; other site
632292003598	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
632292003599	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
632292003600	HIGH motif; other site
632292003601	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
632292003602	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
632292003603	active site
632292003604	KMSKS motif; other site
632292003605	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
632292003606	tRNA binding surface [nucleotide binding]; other site
632292003607	anticodon binding site; other site
632292003608	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
632292003609	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632292003610	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632292003611	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
632292003612	active site
632292003613	intersubunit interactions; other site
632292003614	catalytic residue [active]
632292003615	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
632292003616	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
632292003617	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632292003618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292003619	active site
632292003620	phosphorylation site [posttranslational modification]
632292003621	intermolecular recognition site; other site
632292003622	dimerization interface [polypeptide binding]; other site
632292003623	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632292003624	DNA binding site [nucleotide binding]
632292003625	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
632292003626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632292003627	dimer interface [polypeptide binding]; other site
632292003628	phosphorylation site [posttranslational modification]
632292003629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292003630	ATP binding site [chemical binding]; other site
632292003631	Mg2+ binding site [ion binding]; other site
632292003632	G-X-G motif; other site
632292003633	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
632292003634	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
632292003635	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
632292003636	PhoU domain; Region: PhoU; pfam01895
632292003637	PhoU domain; Region: PhoU; pfam01895
632292003638	QueT transporter; Region: QueT; pfam06177
632292003639	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
632292003640	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
632292003641	dimer interface [polypeptide binding]; other site
632292003642	motif 1; other site
632292003643	active site
632292003644	motif 2; other site
632292003645	motif 3; other site
632292003646	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
632292003647	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
632292003648	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
632292003649	histidinol dehydrogenase; Region: hisD; TIGR00069
632292003650	NAD binding site [chemical binding]; other site
632292003651	dimerization interface [polypeptide binding]; other site
632292003652	product binding site; other site
632292003653	substrate binding site [chemical binding]; other site
632292003654	zinc binding site [ion binding]; other site
632292003655	catalytic residues [active]
632292003656	histidinol-phosphate aminotransferase; Provisional; Region: PRK03967
632292003657	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632292003658	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292003659	homodimer interface [polypeptide binding]; other site
632292003660	catalytic residue [active]
632292003661	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
632292003662	putative active site pocket [active]
632292003663	4-fold oligomerization interface [polypeptide binding]; other site
632292003664	metal binding residues [ion binding]; metal-binding site
632292003665	3-fold/trimer interface [polypeptide binding]; other site
632292003666	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
632292003667	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
632292003668	putative active site [active]
632292003669	oxyanion strand; other site
632292003670	catalytic triad [active]
632292003671	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
632292003672	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
632292003673	catalytic residues [active]
632292003674	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
632292003675	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
632292003676	substrate binding site [chemical binding]; other site
632292003677	glutamase interaction surface [polypeptide binding]; other site
632292003678	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
632292003679	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
632292003680	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
632292003681	metal binding site [ion binding]; metal-binding site
632292003682	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
632292003683	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
632292003684	Substrate binding site; other site
632292003685	Cupin domain; Region: Cupin_2; cl17218
632292003686	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
632292003687	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
632292003688	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
632292003689	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632292003690	Coenzyme A binding pocket [chemical binding]; other site
632292003691	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
632292003692	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
632292003693	minor groove reading motif; other site
632292003694	helix-hairpin-helix signature motif; other site
632292003695	substrate binding pocket [chemical binding]; other site
632292003696	active site
632292003697	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
632292003698	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
632292003699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
632292003700	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
632292003701	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
632292003702	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
632292003703	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
632292003704	putative ATP binding site [chemical binding]; other site
632292003705	putative substrate interface [chemical binding]; other site
632292003706	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
632292003707	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
632292003708	NodB motif; other site
632292003709	active site
632292003710	catalytic site [active]
632292003711	metal binding site [ion binding]; metal-binding site
632292003712	single-stranded DNA-binding protein; Provisional; Region: PRK05813
632292003713	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
632292003714	dimer interface [polypeptide binding]; other site
632292003715	ssDNA binding site [nucleotide binding]; other site
632292003716	tetramer (dimer of dimers) interface [polypeptide binding]; other site
632292003717	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
632292003718	Membrane protein of unknown function; Region: DUF360; cl00850
632292003719	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
632292003720	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
632292003721	dimerization interface [polypeptide binding]; other site
632292003722	putative ATP binding site [chemical binding]; other site
632292003723	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632292003724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292003725	active site
632292003726	phosphorylation site [posttranslational modification]
632292003727	intermolecular recognition site; other site
632292003728	dimerization interface [polypeptide binding]; other site
632292003729	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632292003730	DNA binding site [nucleotide binding]
632292003731	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632292003732	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292003733	dimerization interface [polypeptide binding]; other site
632292003734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632292003735	dimer interface [polypeptide binding]; other site
632292003736	phosphorylation site [posttranslational modification]
632292003737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292003738	ATP binding site [chemical binding]; other site
632292003739	Mg2+ binding site [ion binding]; other site
632292003740	G-X-G motif; other site
632292003741	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
632292003742	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
632292003743	LrgA family; Region: LrgA; cl00608
632292003744	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
632292003745	protein binding site [polypeptide binding]; other site
632292003746	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
632292003747	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
632292003748	Sulfate transporter family; Region: Sulfate_transp; pfam00916
632292003749	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
632292003750	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
632292003751	ATP binding site [chemical binding]; other site
632292003752	active site
632292003753	substrate binding site [chemical binding]; other site
632292003754	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
632292003755	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
632292003756	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
632292003757	putative active site [active]
632292003758	catalytic triad [active]
632292003759	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
632292003760	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
632292003761	dimerization interface [polypeptide binding]; other site
632292003762	ATP binding site [chemical binding]; other site
632292003763	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
632292003764	dimerization interface [polypeptide binding]; other site
632292003765	ATP binding site [chemical binding]; other site
632292003766	amidophosphoribosyltransferase; Provisional; Region: PRK05793
632292003767	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
632292003768	active site
632292003769	tetramer interface [polypeptide binding]; other site
632292003770	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292003771	active site
632292003772	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
632292003773	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
632292003774	dimerization interface [polypeptide binding]; other site
632292003775	putative ATP binding site [chemical binding]; other site
632292003776	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
632292003777	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
632292003778	active site
632292003779	substrate binding site [chemical binding]; other site
632292003780	cosubstrate binding site; other site
632292003781	catalytic site [active]
632292003782	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
632292003783	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
632292003784	purine monophosphate binding site [chemical binding]; other site
632292003785	dimer interface [polypeptide binding]; other site
632292003786	putative catalytic residues [active]
632292003787	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
632292003788	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
632292003789	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
632292003790	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
632292003791	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
632292003792	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
632292003793	Rubredoxin; Region: Rubredoxin; pfam00301
632292003794	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
632292003795	iron binding site [ion binding]; other site
632292003796	DNA polymerase I; Provisional; Region: PRK05755
632292003797	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
632292003798	active site
632292003799	metal binding site 1 [ion binding]; metal-binding site
632292003800	putative 5' ssDNA interaction site; other site
632292003801	metal binding site 3; metal-binding site
632292003802	metal binding site 2 [ion binding]; metal-binding site
632292003803	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
632292003804	putative DNA binding site [nucleotide binding]; other site
632292003805	putative metal binding site [ion binding]; other site
632292003806	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
632292003807	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
632292003808	active site
632292003809	DNA binding site [nucleotide binding]
632292003810	catalytic site [active]
632292003811	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
632292003812	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
632292003813	CoA-binding site [chemical binding]; other site
632292003814	ATP-binding [chemical binding]; other site
632292003815	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
632292003816	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
632292003817	N-acetyl-D-glucosamine binding site [chemical binding]; other site
632292003818	catalytic residue [active]
632292003819	excinuclease ABC subunit B; Provisional; Region: PRK05298
632292003820	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292003821	ATP binding site [chemical binding]; other site
632292003822	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632292003823	nucleotide binding region [chemical binding]; other site
632292003824	ATP-binding site [chemical binding]; other site
632292003825	Ultra-violet resistance protein B; Region: UvrB; pfam12344
632292003826	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
632292003827	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
632292003828	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
632292003829	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
632292003830	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
632292003831	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632292003832	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
632292003833	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632292003834	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
632292003835	Predicted permeases [General function prediction only]; Region: COG0679
632292003836	GMP synthase; Reviewed; Region: guaA; PRK00074
632292003837	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
632292003838	AMP/PPi binding site [chemical binding]; other site
632292003839	candidate oxyanion hole; other site
632292003840	catalytic triad [active]
632292003841	potential glutamine specificity residues [chemical binding]; other site
632292003842	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
632292003843	ATP Binding subdomain [chemical binding]; other site
632292003844	Ligand Binding sites [chemical binding]; other site
632292003845	Dimerization subdomain; other site
632292003846	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
632292003847	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
632292003848	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
632292003849	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
632292003850	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
632292003851	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
632292003852	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
632292003853	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
632292003854	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
632292003855	beta subunit interaction interface [polypeptide binding]; other site
632292003856	Walker A motif; other site
632292003857	ATP binding site [chemical binding]; other site
632292003858	Walker B motif; other site
632292003859	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
632292003860	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
632292003861	core domain interface [polypeptide binding]; other site
632292003862	delta subunit interface [polypeptide binding]; other site
632292003863	epsilon subunit interface [polypeptide binding]; other site
632292003864	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
632292003865	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
632292003866	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
632292003867	alpha subunit interaction interface [polypeptide binding]; other site
632292003868	Walker A motif; other site
632292003869	ATP binding site [chemical binding]; other site
632292003870	Walker B motif; other site
632292003871	inhibitor binding site; inhibition site
632292003872	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
632292003873	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
632292003874	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
632292003875	gamma subunit interface [polypeptide binding]; other site
632292003876	epsilon subunit interface [polypeptide binding]; other site
632292003877	LBP interface [polypeptide binding]; other site
632292003878	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
632292003879	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
632292003880	HSP70 interaction site [polypeptide binding]; other site
632292003881	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
632292003882	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
632292003883	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
632292003884	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
632292003885	trimer interface [polypeptide binding]; other site
632292003886	active site
632292003887	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
632292003888	AsnC family; Region: AsnC_trans_reg; pfam01037
632292003889	hypothetical protein; Validated; Region: PRK07682
632292003890	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632292003891	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292003892	homodimer interface [polypeptide binding]; other site
632292003893	catalytic residue [active]
632292003894	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
632292003895	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
632292003896	active site
632292003897	GTPase Era; Reviewed; Region: era; PRK00089
632292003898	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
632292003899	G1 box; other site
632292003900	GTP/Mg2+ binding site [chemical binding]; other site
632292003901	Switch I region; other site
632292003902	G2 box; other site
632292003903	Switch II region; other site
632292003904	G3 box; other site
632292003905	G4 box; other site
632292003906	G5 box; other site
632292003907	KH domain; Region: KH_2; pfam07650
632292003908	Recombination protein O N terminal; Region: RecO_N; pfam11967
632292003909	DNA repair protein RecO; Region: reco; TIGR00613
632292003910	Recombination protein O C terminal; Region: RecO_C; pfam02565
632292003911	glycyl-tRNA synthetase; Provisional; Region: PRK04173
632292003912	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
632292003913	dimer interface [polypeptide binding]; other site
632292003914	motif 1; other site
632292003915	active site
632292003916	motif 2; other site
632292003917	motif 3; other site
632292003918	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
632292003919	anticodon binding site; other site
632292003920	pyruvate phosphate dikinase; Provisional; Region: PRK09279
632292003921	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
632292003922	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
632292003923	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
632292003924	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
632292003925	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
632292003926	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
632292003927	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
632292003928	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
632292003929	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
632292003930	bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962
632292003931	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
632292003932	substrate binding site [chemical binding]; other site
632292003933	hinge regions; other site
632292003934	ADP binding site [chemical binding]; other site
632292003935	catalytic site [active]
632292003936	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
632292003937	substrate binding site [chemical binding]; other site
632292003938	dimer interface [polypeptide binding]; other site
632292003939	catalytic triad [active]
632292003940	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
632292003941	phosphoglyceromutase; Provisional; Region: PRK05434
632292003942	enolase; Provisional; Region: eno; PRK00077
632292003943	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
632292003944	dimer interface [polypeptide binding]; other site
632292003945	metal binding site [ion binding]; metal-binding site
632292003946	substrate binding pocket [chemical binding]; other site
632292003947	Glucuronate isomerase; Region: UxaC; pfam02614
632292003948	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
632292003949	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
632292003950	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
632292003951	putative active site [active]
632292003952	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632292003953	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
632292003954	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
632292003955	active site
632292003956	DNA binding site [nucleotide binding]
632292003957	Int/Topo IB signature motif; other site
632292003958	Uncharacterized conserved protein [Function unknown]; Region: COG1751
632292003959	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
632292003960	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
632292003961	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
632292003962	putative ligand binding site [chemical binding]; other site
632292003963	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292003964	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
632292003965	TM-ABC transporter signature motif; other site
632292003966	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
632292003967	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
632292003968	TM-ABC transporter signature motif; other site
632292003969	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
632292003970	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
632292003971	Walker A/P-loop; other site
632292003972	ATP binding site [chemical binding]; other site
632292003973	Q-loop/lid; other site
632292003974	ABC transporter signature motif; other site
632292003975	Walker B; other site
632292003976	D-loop; other site
632292003977	H-loop/switch region; other site
632292003978	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
632292003979	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
632292003980	Walker A/P-loop; other site
632292003981	ATP binding site [chemical binding]; other site
632292003982	Q-loop/lid; other site
632292003983	ABC transporter signature motif; other site
632292003984	Walker B; other site
632292003985	D-loop; other site
632292003986	H-loop/switch region; other site
632292003987	Adenylate kinase, active site lid; Region: ADK_lid; pfam05191
632292003988	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292003989	active site
632292003990	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
632292003991	catalytic core [active]
632292003992	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
632292003993	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
632292003994	heterodimer interface [polypeptide binding]; other site
632292003995	active site
632292003996	FMN binding site [chemical binding]; other site
632292003997	homodimer interface [polypeptide binding]; other site
632292003998	substrate binding site [chemical binding]; other site
632292003999	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
632292004000	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
632292004001	FAD binding pocket [chemical binding]; other site
632292004002	FAD binding motif [chemical binding]; other site
632292004003	phosphate binding motif [ion binding]; other site
632292004004	beta-alpha-beta structure motif; other site
632292004005	NAD binding pocket [chemical binding]; other site
632292004006	Iron coordination center [ion binding]; other site
632292004007	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
632292004008	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
632292004009	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
632292004010	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
632292004011	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
632292004012	ATP-grasp domain; Region: ATP-grasp_4; cl17255
632292004013	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
632292004014	IMP binding site; other site
632292004015	dimer interface [polypeptide binding]; other site
632292004016	interdomain contacts; other site
632292004017	partial ornithine binding site; other site
632292004018	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
632292004019	active site
632292004020	dimer interface [polypeptide binding]; other site
632292004021	dihydroorotase; Validated; Region: pyrC; PRK09357
632292004022	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
632292004023	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
632292004024	active site
632292004025	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
632292004026	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
632292004027	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
632292004028	uracil transporter; Provisional; Region: PRK10720
632292004029	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
632292004030	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292004031	active site
632292004032	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
632292004033	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632292004034	RNA binding surface [nucleotide binding]; other site
632292004035	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
632292004036	active site
632292004037	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292004038	lipoprotein signal peptidase; Provisional; Region: PRK14791
632292004039	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
632292004040	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
632292004041	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
632292004042	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
632292004043	Putative amidase domain; Region: Amidase_6; pfam12671
632292004044	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
632292004045	SnoaL-like domain; Region: SnoaL_4; cl17707
632292004046	Penicillinase repressor; Region: Pencillinase_R; cl17580
632292004047	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
632292004048	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
632292004049	active site
632292004050	dimer interface [polypeptide binding]; other site
632292004051	metal binding site [ion binding]; metal-binding site
632292004052	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
632292004053	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
632292004054	HIGH motif; other site
632292004055	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
632292004056	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
632292004057	active site
632292004058	KMSKS motif; other site
632292004059	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
632292004060	tRNA binding surface [nucleotide binding]; other site
632292004061	anticodon binding site; other site
632292004062	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
632292004063	DivIVA protein; Region: DivIVA; pfam05103
632292004064	DivIVA domain; Region: DivI1A_domain; TIGR03544
632292004065	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
632292004066	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
632292004067	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632292004068	RNA binding surface [nucleotide binding]; other site
632292004069	YGGT family; Region: YGGT; pfam02325
632292004070	Protein of unknown function (DUF552); Region: DUF552; pfam04472
632292004071	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
632292004072	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
632292004073	catalytic residue [active]
632292004074	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
632292004075	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632292004076	active site
632292004077	PHP-associated; Region: PHP_C; pfam13263
632292004078	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
632292004079	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
632292004080	dimer interface [polypeptide binding]; other site
632292004081	ADP-ribose binding site [chemical binding]; other site
632292004082	active site
632292004083	nudix motif; other site
632292004084	metal binding site [ion binding]; metal-binding site
632292004085	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
632292004086	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
632292004087	RNA/DNA hybrid binding site [nucleotide binding]; other site
632292004088	active site
632292004089	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
632292004090	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
632292004091	stage V sporulation protein B; Region: spore_V_B; TIGR02900
632292004092	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
632292004093	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
632292004094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292004095	active site
632292004096	phosphorylation site [posttranslational modification]
632292004097	intermolecular recognition site; other site
632292004098	dimerization interface [polypeptide binding]; other site
632292004099	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
632292004100	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
632292004101	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
632292004102	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
632292004103	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
632292004104	Walker A/P-loop; other site
632292004105	ATP binding site [chemical binding]; other site
632292004106	Q-loop/lid; other site
632292004107	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
632292004108	ABC transporter signature motif; other site
632292004109	Walker B; other site
632292004110	D-loop; other site
632292004111	H-loop/switch region; other site
632292004112	arginine repressor; Provisional; Region: argR; PRK00441
632292004113	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
632292004114	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
632292004115	ATP-NAD kinase; Region: NAD_kinase; pfam01513
632292004116	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
632292004117	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
632292004118	nucleotide binding site/active site [active]
632292004119	HIT family signature motif; other site
632292004120	catalytic residue [active]
632292004121	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
632292004122	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
632292004123	motif 1; other site
632292004124	active site
632292004125	motif 2; other site
632292004126	motif 3; other site
632292004127	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
632292004128	DHHA1 domain; Region: DHHA1; pfam02272
632292004129	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
632292004130	Domain of unknown function DUF20; Region: UPF0118; pfam01594
632292004131	PRC-barrel domain; Region: PRC; pfam05239
632292004132	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
632292004133	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
632292004134	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
632292004135	RNA binding site [nucleotide binding]; other site
632292004136	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
632292004137	RNA binding site [nucleotide binding]; other site
632292004138	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
632292004139	RNA binding site [nucleotide binding]; other site
632292004140	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
632292004141	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
632292004142	putative acyl-acceptor binding pocket; other site
632292004143	cytidylate kinase; Provisional; Region: cmk; PRK00023
632292004144	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
632292004145	CMP-binding site; other site
632292004146	The sites determining sugar specificity; other site
632292004147	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
632292004148	homotrimer interaction site [polypeptide binding]; other site
632292004149	active site
632292004150	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
632292004151	hexamer interface [polypeptide binding]; other site
632292004152	RNA binding site [nucleotide binding]; other site
632292004153	Histidine-zinc binding site [chemical binding]; other site
632292004154	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
632292004155	catalytic core [active]
632292004156	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
632292004157	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
632292004158	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
632292004159	putative active site [active]
632292004160	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
632292004161	oxaloacetate decarboxylase; Provisional; Region: PRK12331
632292004162	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
632292004163	active site
632292004164	catalytic residues [active]
632292004165	metal binding site [ion binding]; metal-binding site
632292004166	homodimer binding site [polypeptide binding]; other site
632292004167	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
632292004168	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
632292004169	carboxyltransferase (CT) interaction site; other site
632292004170	biotinylation site [posttranslational modification]; other site
632292004171	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
632292004172	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
632292004173	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
632292004174	agmatinase; Region: agmatinase; TIGR01230
632292004175	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
632292004176	putative active site [active]
632292004177	Mn binding site [ion binding]; other site
632292004178	spermidine synthase; Provisional; Region: PRK00811
632292004179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292004180	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
632292004181	active site
632292004182	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
632292004183	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
632292004184	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
632292004185	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
632292004186	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
632292004187	active site
632292004188	dimer interfaces [polypeptide binding]; other site
632292004189	catalytic residues [active]
632292004190	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
632292004191	Septum formation topological specificity factor MinE; Region: MinE; cl00538
632292004192	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
632292004193	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
632292004194	P-loop; other site
632292004195	ADP binding residues [chemical binding]; other site
632292004196	Switch I; other site
632292004197	Switch II; other site
632292004198	septum formation inhibitor; Reviewed; Region: minC; PRK00513
632292004199	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
632292004200	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
632292004201	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
632292004202	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
632292004203	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
632292004204	rod shape-determining protein MreC; Provisional; Region: PRK13922
632292004205	rod shape-determining protein MreC; Region: MreC; pfam04085
632292004206	rod shape-determining protein MreB; Provisional; Region: PRK13927
632292004207	MreB and similar proteins; Region: MreB_like; cd10225
632292004208	nucleotide binding site [chemical binding]; other site
632292004209	Mg binding site [ion binding]; other site
632292004210	putative protofilament interaction site [polypeptide binding]; other site
632292004211	RodZ interaction site [polypeptide binding]; other site
632292004212	Maf-like protein; Region: Maf; pfam02545
632292004213	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
632292004214	active site
632292004215	dimer interface [polypeptide binding]; other site
632292004216	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
632292004217	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
632292004218	catalytic loop [active]
632292004219	iron binding site [ion binding]; other site
632292004220	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
632292004221	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
632292004222	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
632292004223	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
632292004224	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
632292004225	dimer interface [polypeptide binding]; other site
632292004226	[2Fe-2S] cluster binding site [ion binding]; other site
632292004227	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
632292004228	SLBB domain; Region: SLBB; pfam10531
632292004229	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
632292004230	4Fe-4S binding domain; Region: Fer4; pfam00037
632292004231	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
632292004232	4Fe-4S binding domain; Region: Fer4; pfam00037
632292004233	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
632292004234	dimer interface [polypeptide binding]; other site
632292004235	[2Fe-2S] cluster binding site [ion binding]; other site
632292004236	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632292004237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292004238	ATP binding site [chemical binding]; other site
632292004239	Mg2+ binding site [ion binding]; other site
632292004240	G-X-G motif; other site
632292004241	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
632292004242	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
632292004243	putative dimer interface [polypeptide binding]; other site
632292004244	[2Fe-2S] cluster binding site [ion binding]; other site
632292004245	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
632292004246	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
632292004247	active site
632292004248	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632292004249	DRTGG domain; Region: DRTGG; pfam07085
632292004250	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
632292004251	4Fe-4S binding domain; Region: Fer4; pfam00037
632292004252	4Fe-4S binding domain; Region: Fer4; cl02805
632292004253	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
632292004254	Putative Fe-S cluster; Region: FeS; cl17515
632292004255	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
632292004256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292004257	ATP binding site [chemical binding]; other site
632292004258	G-X-G motif; other site
632292004259	DRTGG domain; Region: DRTGG; pfam07085
632292004260	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
632292004261	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632292004262	RNA binding surface [nucleotide binding]; other site
632292004263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292004264	S-adenosylmethionine binding site [chemical binding]; other site
632292004265	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
632292004266	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
632292004267	TPP-binding site; other site
632292004268	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
632292004269	PYR/PP interface [polypeptide binding]; other site
632292004270	dimer interface [polypeptide binding]; other site
632292004271	TPP binding site [chemical binding]; other site
632292004272	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
632292004273	Divergent PAP2 family; Region: DUF212; pfam02681
632292004274	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
632292004275	Part of AAA domain; Region: AAA_19; pfam13245
632292004276	Family description; Region: UvrD_C_2; pfam13538
632292004277	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
632292004278	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
632292004279	putative tRNA-binding site [nucleotide binding]; other site
632292004280	B3/4 domain; Region: B3_4; pfam03483
632292004281	tRNA synthetase B5 domain; Region: B5; smart00874
632292004282	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
632292004283	dimer interface [polypeptide binding]; other site
632292004284	motif 1; other site
632292004285	motif 3; other site
632292004286	motif 2; other site
632292004287	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
632292004288	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
632292004289	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
632292004290	dimer interface [polypeptide binding]; other site
632292004291	motif 1; other site
632292004292	active site
632292004293	motif 2; other site
632292004294	motif 3; other site
632292004295	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
632292004296	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
632292004297	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292004298	FeS/SAM binding site; other site
632292004299	TRAM domain; Region: TRAM; cl01282
632292004300	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
632292004301	regulatory protein interface [polypeptide binding]; other site
632292004302	regulatory phosphorylation site [posttranslational modification]; other site
632292004303	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
632292004304	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
632292004305	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
632292004306	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
632292004307	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
632292004308	Tetramer interface [polypeptide binding]; other site
632292004309	active site
632292004310	FMN-binding site [chemical binding]; other site
632292004311	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
632292004312	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632292004313	Beta-Casp domain; Region: Beta-Casp; smart01027
632292004314	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
632292004315	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
632292004316	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
632292004317	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
632292004318	active site
632292004319	metal-binding heat shock protein; Provisional; Region: PRK00016
632292004320	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
632292004321	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292004322	Zn2+ binding site [ion binding]; other site
632292004323	Mg2+ binding site [ion binding]; other site
632292004324	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
632292004325	PhoH-like protein; Region: PhoH; pfam02562
632292004326	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
632292004327	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
632292004328	YabP family; Region: YabP; cl06766
632292004329	Yqey-like protein; Region: YqeY; pfam09424
632292004330	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
632292004331	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
632292004332	active site
632292004333	pyruvate kinase; Provisional; Region: PRK06354
632292004334	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
632292004335	domain interfaces; other site
632292004336	active site
632292004337	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
632292004338	6-phosphofructokinase; Provisional; Region: PRK03202
632292004339	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
632292004340	active site
632292004341	ADP/pyrophosphate binding site [chemical binding]; other site
632292004342	dimerization interface [polypeptide binding]; other site
632292004343	allosteric effector site; other site
632292004344	fructose-1,6-bisphosphate binding site; other site
632292004345	transcription attenuation protein MtrB; Provisional; Region: PRK13251
632292004346	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
632292004347	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
632292004348	active site
632292004349	PHP Thumb interface [polypeptide binding]; other site
632292004350	metal binding site [ion binding]; metal-binding site
632292004351	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
632292004352	generic binding surface II; other site
632292004353	generic binding surface I; other site
632292004354	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632292004355	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292004356	Zn2+ binding site [ion binding]; other site
632292004357	Mg2+ binding site [ion binding]; other site
632292004358	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
632292004359	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
632292004360	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
632292004361	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
632292004362	SLBB domain; Region: SLBB; pfam10531
632292004363	comEA protein; Region: comE; TIGR01259
632292004364	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
632292004365	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
632292004366	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
632292004367	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
632292004368	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
632292004369	HIGH motif; other site
632292004370	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
632292004371	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
632292004372	active site
632292004373	KMSKS motif; other site
632292004374	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
632292004375	tRNA binding surface [nucleotide binding]; other site
632292004376	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
632292004377	Transcriptional regulator [Transcription]; Region: LytR; COG1316
632292004378	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292004379	Zn2+ binding site [ion binding]; other site
632292004380	Mg2+ binding site [ion binding]; other site
632292004381	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
632292004382	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
632292004383	active site
632292004384	(T/H)XGH motif; other site
632292004385	argininosuccinate synthase; Provisional; Region: PRK13820
632292004386	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
632292004387	ANP binding site [chemical binding]; other site
632292004388	Substrate Binding Site II [chemical binding]; other site
632292004389	Substrate Binding Site I [chemical binding]; other site
632292004390	argininosuccinate lyase; Provisional; Region: PRK00855
632292004391	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
632292004392	active sites [active]
632292004393	tetramer interface [polypeptide binding]; other site
632292004394	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
632292004395	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
632292004396	5S rRNA interface [nucleotide binding]; other site
632292004397	CTC domain interface [polypeptide binding]; other site
632292004398	L16 interface [polypeptide binding]; other site
632292004399	Protein of unknown function, DUF624; Region: DUF624; cl02369
632292004400	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
632292004401	Transcriptional regulator [Transcription]; Region: LytR; COG1316
632292004402	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292004403	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
632292004404	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
632292004405	O-Antigen ligase; Region: Wzy_C; pfam04932
632292004406	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
632292004407	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
632292004408	putative trimer interface [polypeptide binding]; other site
632292004409	putative trimer interface [polypeptide binding]; other site
632292004410	putative active site [active]
632292004411	putative substrate binding site [chemical binding]; other site
632292004412	putative CoA binding site [chemical binding]; other site
632292004413	putative CoA binding site [chemical binding]; other site
632292004414	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632292004415	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632292004416	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
632292004417	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
632292004418	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
632292004419	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
632292004420	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
632292004421	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
632292004422	inhibitor-cofactor binding pocket; inhibition site
632292004423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292004424	catalytic residue [active]
632292004425	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
632292004426	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632292004427	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
632292004428	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
632292004429	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
632292004430	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
632292004431	Ligand binding site [chemical binding]; other site
632292004432	Electron transfer flavoprotein domain; Region: ETF; pfam01012
632292004433	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
632292004434	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
632292004435	FAD binding site [chemical binding]; other site
632292004436	homotetramer interface [polypeptide binding]; other site
632292004437	substrate binding pocket [chemical binding]; other site
632292004438	catalytic base [active]
632292004439	hypothetical protein; Provisional; Region: PRK13670
632292004440	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
632292004441	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
632292004442	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
632292004443	active site
632292004444	nucleophile elbow; other site
632292004445	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
632292004446	Nucleoside recognition; Region: Gate; pfam07670
632292004447	phosphodiesterase; Provisional; Region: PRK12704
632292004448	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
632292004449	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
632292004450	active site
632292004451	(T/H)XGH motif; other site
632292004452	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
632292004453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292004454	S-adenosylmethionine binding site [chemical binding]; other site
632292004455	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
632292004456	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
632292004457	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
632292004458	ssDNA binding site; other site
632292004459	generic binding surface II; other site
632292004460	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292004461	ATP binding site [chemical binding]; other site
632292004462	putative Mg++ binding site [ion binding]; other site
632292004463	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632292004464	nucleotide binding region [chemical binding]; other site
632292004465	ATP-binding site [chemical binding]; other site
632292004466	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
632292004467	DAK2 domain; Region: Dak2; pfam02734
632292004468	Asp23 family; Region: Asp23; pfam03780
632292004469	Predicted membrane protein [Function unknown]; Region: COG3601
632292004470	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
632292004471	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
632292004472	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632292004473	RNA binding surface [nucleotide binding]; other site
632292004474	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
632292004475	active site
632292004476	uracil binding [chemical binding]; other site
632292004477	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
632292004478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292004479	S-adenosylmethionine binding site [chemical binding]; other site
632292004480	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
632292004481	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
632292004482	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
632292004483	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
632292004484	putative RNA binding site [nucleotide binding]; other site
632292004485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292004486	S-adenosylmethionine binding site [chemical binding]; other site
632292004487	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
632292004488	nudix motif; other site
632292004489	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
632292004490	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
632292004491	GTP binding site; other site
632292004492	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
632292004493	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
632292004494	putative [4Fe-4S] binding site [ion binding]; other site
632292004495	putative molybdopterin cofactor binding site [chemical binding]; other site
632292004496	Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568
632292004497	molybdopterin cofactor binding site; other site
632292004498	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
632292004499	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
632292004500	dimerization interface [polypeptide binding]; other site
632292004501	active site
632292004502	L-aspartate oxidase; Provisional; Region: PRK06175
632292004503	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
632292004504	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
632292004505	Quinolinate synthetase A protein; Region: NadA; pfam02445
632292004506	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
632292004507	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632292004508	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
632292004509	active site
632292004510	catalytic tetrad [active]
632292004511	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632292004512	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
632292004513	hypothetical protein; Provisional; Region: PRK05473
632292004514	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
632292004515	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
632292004516	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
632292004517	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
632292004518	23S rRNA binding site [nucleotide binding]; other site
632292004519	L21 binding site [polypeptide binding]; other site
632292004520	L13 binding site [polypeptide binding]; other site
632292004521	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
632292004522	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
632292004523	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
632292004524	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
632292004525	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
632292004526	dimer interface [polypeptide binding]; other site
632292004527	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
632292004528	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
632292004529	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
632292004530	Ligand Binding Site [chemical binding]; other site
632292004531	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
632292004532	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
632292004533	inhibitor-cofactor binding pocket; inhibition site
632292004534	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292004535	catalytic residue [active]
632292004536	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
632292004537	dimer interface [polypeptide binding]; other site
632292004538	active site
632292004539	Schiff base residues; other site
632292004540	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
632292004541	active site
632292004542	SAM binding site [chemical binding]; other site
632292004543	homodimer interface [polypeptide binding]; other site
632292004544	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
632292004545	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
632292004546	active site
632292004547	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
632292004548	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
632292004549	domain interfaces; other site
632292004550	active site
632292004551	precorrin-2 dehydrogenase; Provisional; Region: PRK05562
632292004552	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
632292004553	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
632292004554	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
632292004555	tRNA; other site
632292004556	putative tRNA binding site [nucleotide binding]; other site
632292004557	putative NADP binding site [chemical binding]; other site
632292004558	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
632292004559	Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007
632292004560	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
632292004561	TatD related DNase; Region: TatD_DNase; pfam01026
632292004562	active site
632292004563	Uncharacterized conserved protein [Function unknown]; Region: COG1416
632292004564	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
632292004565	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
632292004566	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
632292004567	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
632292004568	4Fe-4S binding domain; Region: Fer4; cl02805
632292004569	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
632292004570	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
632292004571	FAD binding pocket [chemical binding]; other site
632292004572	FAD binding motif [chemical binding]; other site
632292004573	phosphate binding motif [ion binding]; other site
632292004574	beta-alpha-beta structure motif; other site
632292004575	NAD binding pocket [chemical binding]; other site
632292004576	Iron coordination center [ion binding]; other site
632292004577	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
632292004578	Arginosuccinate synthase; Region: Arginosuc_synth; cl17227
632292004579	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632292004580	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
632292004581	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
632292004582	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
632292004583	putative dimerization interface [polypeptide binding]; other site
632292004584	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
632292004585	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
632292004586	CysD dimerization site [polypeptide binding]; other site
632292004587	G1 box; other site
632292004588	putative GEF interaction site [polypeptide binding]; other site
632292004589	GTP/Mg2+ binding site [chemical binding]; other site
632292004590	Switch I region; other site
632292004591	G2 box; other site
632292004592	G3 box; other site
632292004593	Switch II region; other site
632292004594	G4 box; other site
632292004595	G5 box; other site
632292004596	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
632292004597	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
632292004598	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
632292004599	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
632292004600	Active Sites [active]
632292004601	Ferredoxin [Energy production and conversion]; Region: COG1146
632292004602	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632292004603	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
632292004604	L-aspartate oxidase; Provisional; Region: PRK06175
632292004605	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
632292004606	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
632292004607	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
632292004608	homodimer interface [polypeptide binding]; other site
632292004609	substrate-cofactor binding pocket; other site
632292004610	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292004611	catalytic residue [active]
632292004612	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
632292004613	CPxP  motif; other site
632292004614	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
632292004615	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
632292004616	4Fe-4S binding domain; Region: Fer4; pfam00037
632292004617	4Fe-4S binding domain; Region: Fer4; pfam00037
632292004618	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
632292004619	MPN+ (JAMM) motif; other site
632292004620	Zinc-binding site [ion binding]; other site
632292004621	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
632292004622	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
632292004623	ATP binding site [chemical binding]; other site
632292004624	substrate interface [chemical binding]; other site
632292004625	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
632292004626	thiS-thiF/thiG interaction site; other site
632292004627	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
632292004628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292004629	dimer interface [polypeptide binding]; other site
632292004630	conserved gate region; other site
632292004631	putative PBP binding loops; other site
632292004632	ABC-ATPase subunit interface; other site
632292004633	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
632292004634	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
632292004635	Walker A/P-loop; other site
632292004636	ATP binding site [chemical binding]; other site
632292004637	Q-loop/lid; other site
632292004638	ABC transporter signature motif; other site
632292004639	Walker B; other site
632292004640	D-loop; other site
632292004641	H-loop/switch region; other site
632292004642	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
632292004643	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
632292004644	substrate binding pocket [chemical binding]; other site
632292004645	Protein of unknown function (DUF3834); Region: DUF3834; pfam12916
632292004646	membrane-bound complex binding site; other site
632292004647	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
632292004648	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
632292004649	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632292004650	AIR carboxylase; Region: AIRC; pfam00731
632292004651	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
632292004652	ATP-grasp domain; Region: ATP-grasp; pfam02222
632292004653	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
632292004654	hybrid cluster protein; Provisional; Region: PRK05290
632292004655	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632292004656	ACS interaction site; other site
632292004657	CODH interaction site; other site
632292004658	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
632292004659	hybrid metal cluster; other site
632292004660	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632292004661	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
632292004662	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
632292004663	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
632292004664	ligand binding site [chemical binding]; other site
632292004665	flexible hinge region; other site
632292004666	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
632292004667	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
632292004668	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
632292004669	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
632292004670	P loop; other site
632292004671	GTP binding site [chemical binding]; other site
632292004672	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
632292004673	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
632292004674	Walker A/P-loop; other site
632292004675	ATP binding site [chemical binding]; other site
632292004676	Q-loop/lid; other site
632292004677	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
632292004678	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
632292004679	ABC transporter signature motif; other site
632292004680	Walker B; other site
632292004681	D-loop; other site
632292004682	H-loop/switch region; other site
632292004683	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
632292004684	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
632292004685	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292004686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292004687	dimer interface [polypeptide binding]; other site
632292004688	conserved gate region; other site
632292004689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
632292004690	ABC-ATPase subunit interface; other site
632292004691	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
632292004692	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
632292004693	Walker A/P-loop; other site
632292004694	ATP binding site [chemical binding]; other site
632292004695	Q-loop/lid; other site
632292004696	ABC transporter signature motif; other site
632292004697	Walker B; other site
632292004698	D-loop; other site
632292004699	H-loop/switch region; other site
632292004700	NIL domain; Region: NIL; pfam09383
632292004701	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
632292004702	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
632292004703	dimer interface [polypeptide binding]; other site
632292004704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292004705	catalytic residue [active]
632292004706	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
632292004707	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
632292004708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292004709	dimer interface [polypeptide binding]; other site
632292004710	conserved gate region; other site
632292004711	putative PBP binding loops; other site
632292004712	ABC-ATPase subunit interface; other site
632292004713	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
632292004714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292004715	dimer interface [polypeptide binding]; other site
632292004716	conserved gate region; other site
632292004717	putative PBP binding loops; other site
632292004718	ABC-ATPase subunit interface; other site
632292004719	PBP superfamily domain; Region: PBP_like_2; cl17296
632292004720	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
632292004721	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
632292004722	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292004723	FeS/SAM binding site; other site
632292004724	ribonuclease III; Reviewed; Region: rnc; PRK00102
632292004725	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
632292004726	dimerization interface [polypeptide binding]; other site
632292004727	active site
632292004728	metal binding site [ion binding]; metal-binding site
632292004729	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
632292004730	dsRNA binding site [nucleotide binding]; other site
632292004731	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
632292004732	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
632292004733	dimer interface [polypeptide binding]; other site
632292004734	active site
632292004735	acyl carrier protein; Provisional; Region: acpP; PRK00982
632292004736	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
632292004737	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
632292004738	NAD(P) binding site [chemical binding]; other site
632292004739	homotetramer interface [polypeptide binding]; other site
632292004740	homodimer interface [polypeptide binding]; other site
632292004741	active site
632292004742	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
632292004743	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
632292004744	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
632292004745	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
632292004746	dimer interface [polypeptide binding]; other site
632292004747	active site
632292004748	CoA binding pocket [chemical binding]; other site
632292004749	putative phosphate acyltransferase; Provisional; Region: PRK05331
632292004750	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
632292004751	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
632292004752	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
632292004753	active site 1 [active]
632292004754	active site 2 [active]
632292004755	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
632292004756	active site
632292004757	tetramer interface; other site
632292004758	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
632292004759	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
632292004760	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632292004761	NAD(P) binding site [chemical binding]; other site
632292004762	active site
632292004763	recombination protein RecR; Reviewed; Region: recR; PRK00076
632292004764	RecR protein; Region: RecR; pfam02132
632292004765	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
632292004766	putative active site [active]
632292004767	putative metal-binding site [ion binding]; other site
632292004768	tetramer interface [polypeptide binding]; other site
632292004769	hypothetical protein; Validated; Region: PRK00153
632292004770	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
632292004771	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292004772	Walker A/P-loop; other site
632292004773	ATP binding site [chemical binding]; other site
632292004774	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
632292004775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292004776	ABC transporter signature motif; other site
632292004777	Walker B; other site
632292004778	D-loop; other site
632292004779	H-loop/switch region; other site
632292004780	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
632292004781	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
632292004782	active site
632292004783	metal binding site [ion binding]; metal-binding site
632292004784	DNA binding site [nucleotide binding]
632292004785	HerA helicase [Replication, recombination, and repair]; Region: COG0433
632292004786	Domain of unknown function DUF87; Region: DUF87; pfam01935
632292004787	NurA nuclease; Region: NurA; smart00933
632292004788	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
632292004789	homotrimer interaction site [polypeptide binding]; other site
632292004790	zinc binding site [ion binding]; other site
632292004791	CDP-binding sites; other site
632292004792	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
632292004793	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
632292004794	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
632292004795	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
632292004796	dihydrodipicolinate synthase; Region: dapA; TIGR00674
632292004797	dimer interface [polypeptide binding]; other site
632292004798	active site
632292004799	catalytic residue [active]
632292004800	dihydrodipicolinate reductase; Provisional; Region: PRK00048
632292004801	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
632292004802	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
632292004803	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
632292004804	putative allosteric regulatory site; other site
632292004805	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
632292004806	putative allosteric regulatory residue; other site
632292004807	reverse gyrase; Reviewed; Region: PRK09401
632292004808	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292004809	ATP binding site [chemical binding]; other site
632292004810	TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove; Region: TOPRIM_TopoIA_RevGyr; cd03361
632292004811	active site
632292004812	putative interdomain interaction site [polypeptide binding]; other site
632292004813	putative metal-binding site [ion binding]; other site
632292004814	putative nucleotide binding site [chemical binding]; other site
632292004815	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
632292004816	domain I; other site
632292004817	DNA binding groove [nucleotide binding]
632292004818	phosphate binding site [ion binding]; other site
632292004819	domain II; other site
632292004820	domain III; other site
632292004821	nucleotide binding site [chemical binding]; other site
632292004822	catalytic site [active]
632292004823	domain IV; other site
632292004824	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
632292004825	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
632292004826	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292004827	dimer interface [polypeptide binding]; other site
632292004828	putative CheW interface [polypeptide binding]; other site
632292004829	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
632292004830	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
632292004831	tetramer interface [polypeptide binding]; other site
632292004832	active site
632292004833	aspartate aminotransferase; Provisional; Region: PRK05764
632292004834	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632292004835	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292004836	homodimer interface [polypeptide binding]; other site
632292004837	catalytic residue [active]
632292004838	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
632292004839	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
632292004840	active site
632292004841	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
632292004842	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
632292004843	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
632292004844	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
632292004845	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
632292004846	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
632292004847	homodimer interface [polypeptide binding]; other site
632292004848	substrate-cofactor binding pocket; other site
632292004849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292004850	catalytic residue [active]
632292004851	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
632292004852	GTPase CgtA; Reviewed; Region: obgE; PRK12297
632292004853	GTP1/OBG; Region: GTP1_OBG; pfam01018
632292004854	Obg GTPase; Region: Obg; cd01898
632292004855	G1 box; other site
632292004856	GTP/Mg2+ binding site [chemical binding]; other site
632292004857	Switch I region; other site
632292004858	G2 box; other site
632292004859	G3 box; other site
632292004860	Switch II region; other site
632292004861	G4 box; other site
632292004862	G5 box; other site
632292004863	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
632292004864	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
632292004865	hypothetical protein; Provisional; Region: PRK14553
632292004866	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
632292004867	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
632292004868	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
632292004869	Ligand Binding Site [chemical binding]; other site
632292004870	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
632292004871	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292004872	Walker A motif; other site
632292004873	ATP binding site [chemical binding]; other site
632292004874	Walker B motif; other site
632292004875	arginine finger; other site
632292004876	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
632292004877	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
632292004878	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
632292004879	active site
632292004880	putative DNA-binding cleft [nucleotide binding]; other site
632292004881	dimer interface [polypeptide binding]; other site
632292004882	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
632292004883	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632292004884	Coenzyme A binding pocket [chemical binding]; other site
632292004885	alpha-galactosidase; Provisional; Region: PRK15076
632292004886	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
632292004887	NAD binding site [chemical binding]; other site
632292004888	sugar binding site [chemical binding]; other site
632292004889	divalent metal binding site [ion binding]; other site
632292004890	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
632292004891	dimer interface [polypeptide binding]; other site
632292004892	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
632292004893	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
632292004894	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
632292004895	substrate binding site [chemical binding]; other site
632292004896	active site
632292004897	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632292004898	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
632292004899	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
632292004900	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
632292004901	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
632292004902	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292004903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292004904	dimer interface [polypeptide binding]; other site
632292004905	conserved gate region; other site
632292004906	ABC-ATPase subunit interface; other site
632292004907	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292004908	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292004909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292004910	dimer interface [polypeptide binding]; other site
632292004911	conserved gate region; other site
632292004912	putative PBP binding loops; other site
632292004913	ABC-ATPase subunit interface; other site
632292004914	S-layer homology domain; Region: SLH; pfam00395
632292004915	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
632292004916	substrate binding site [chemical binding]; other site
632292004917	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
632292004918	active site
632292004919	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
632292004920	calcium mediated ligand binding site; other site
632292004921	intermolecular salt bridges; other site
632292004922	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
632292004923	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292004924	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292004925	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292004926	dimer interface [polypeptide binding]; other site
632292004927	conserved gate region; other site
632292004928	putative PBP binding loops; other site
632292004929	ABC-ATPase subunit interface; other site
632292004930	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292004931	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292004932	dimer interface [polypeptide binding]; other site
632292004933	conserved gate region; other site
632292004934	putative PBP binding loops; other site
632292004935	ABC-ATPase subunit interface; other site
632292004936	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292004937	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292004938	Predicted transcriptional regulator [Transcription]; Region: COG4189
632292004939	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292004940	dimerization interface [polypeptide binding]; other site
632292004941	putative DNA binding site [nucleotide binding]; other site
632292004942	putative Zn2+ binding site [ion binding]; other site
632292004943	Haemolysin XhlA; Region: XhlA; pfam10779
632292004944	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
632292004945	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
632292004946	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
632292004947	VanW like protein; Region: VanW; pfam04294
632292004948	G5 domain; Region: G5; pfam07501
632292004949	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
632292004950	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
632292004951	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
632292004952	TPP-binding site [chemical binding]; other site
632292004953	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
632292004954	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632292004955	dimer interface [polypeptide binding]; other site
632292004956	PYR/PP interface [polypeptide binding]; other site
632292004957	TPP binding site [chemical binding]; other site
632292004958	substrate binding site [chemical binding]; other site
632292004959	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
632292004960	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632292004961	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
632292004962	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
632292004963	dimerization interface [polypeptide binding]; other site
632292004964	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
632292004965	ATP binding site [chemical binding]; other site
632292004966	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
632292004967	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
632292004968	HupF/HypC family; Region: HupF_HypC; pfam01455
632292004969	Acylphosphatase; Region: Acylphosphatase; pfam00708
632292004970	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
632292004971	HypF finger; Region: zf-HYPF; pfam07503
632292004972	HypF finger; Region: zf-HYPF; pfam07503
632292004973	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
632292004974	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
632292004975	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
632292004976	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
632292004977	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
632292004978	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632292004979	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
632292004980	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
632292004981	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
632292004982	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
632292004983	NADH dehydrogenase; Region: NADHdh; cl00469
632292004984	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
632292004985	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651
632292004986	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
632292004987	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292004988	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
632292004989	active site
632292004990	motif I; other site
632292004991	motif II; other site
632292004992	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
632292004993	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
632292004994	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
632292004995	AMIN domain; Region: AMIN; pfam11741
632292004996	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
632292004997	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
632292004998	active site
632292004999	metal binding site [ion binding]; metal-binding site
632292005000	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
632292005001	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
632292005002	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
632292005003	feedback inhibition sensing region; other site
632292005004	homohexameric interface [polypeptide binding]; other site
632292005005	nucleotide binding site [chemical binding]; other site
632292005006	N-acetyl-L-glutamate binding site [chemical binding]; other site
632292005007	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
632292005008	Low molecular weight phosphatase family; Region: LMWPc; cd00115
632292005009	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
632292005010	active site
632292005011	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
632292005012	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
632292005013	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
632292005014	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
632292005015	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
632292005016	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
632292005017	ligand binding site [chemical binding]; other site
632292005018	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
632292005019	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
632292005020	peptide chain release factor 1; Validated; Region: prfA; PRK00591
632292005021	This domain is found in peptide chain release factors; Region: PCRF; smart00937
632292005022	RF-1 domain; Region: RF-1; pfam00472
632292005023	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
632292005024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292005025	S-adenosylmethionine binding site [chemical binding]; other site
632292005026	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
632292005027	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
632292005028	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632292005029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292005030	putative substrate translocation pore; other site
632292005031	Protease prsW family; Region: PrsW-protease; pfam13367
632292005032	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
632292005033	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
632292005034	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
632292005035	minor groove reading motif; other site
632292005036	helix-hairpin-helix signature motif; other site
632292005037	substrate binding pocket [chemical binding]; other site
632292005038	active site
632292005039	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
632292005040	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
632292005041	active site
632292005042	metal binding site [ion binding]; metal-binding site
632292005043	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
632292005044	transcription termination factor Rho; Provisional; Region: PRK12608
632292005045	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
632292005046	RNA binding site [nucleotide binding]; other site
632292005047	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
632292005048	Walker A motif; other site
632292005049	ATP binding site [chemical binding]; other site
632292005050	Walker B motif; other site
632292005051	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
632292005052	Malic enzyme, N-terminal domain; Region: malic; pfam00390
632292005053	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
632292005054	putative NAD(P) binding site [chemical binding]; other site
632292005055	recombination factor protein RarA; Reviewed; Region: PRK13342
632292005056	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292005057	Walker A motif; other site
632292005058	ATP binding site [chemical binding]; other site
632292005059	Walker B motif; other site
632292005060	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
632292005061	arginine finger; other site
632292005062	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
632292005063	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
632292005064	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
632292005065	dimer interface [polypeptide binding]; other site
632292005066	active site
632292005067	glycine-pyridoxal phosphate binding site [chemical binding]; other site
632292005068	folate binding site [chemical binding]; other site
632292005069	Uncharacterized conserved protein [Function unknown]; Region: COG2966
632292005070	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
632292005071	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
632292005072	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
632292005073	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
632292005074	RNase E interface [polypeptide binding]; other site
632292005075	trimer interface [polypeptide binding]; other site
632292005076	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
632292005077	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
632292005078	RNase E interface [polypeptide binding]; other site
632292005079	trimer interface [polypeptide binding]; other site
632292005080	active site
632292005081	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
632292005082	putative nucleic acid binding region [nucleotide binding]; other site
632292005083	G-X-X-G motif; other site
632292005084	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
632292005085	RNA binding site [nucleotide binding]; other site
632292005086	domain interface; other site
632292005087	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
632292005088	16S/18S rRNA binding site [nucleotide binding]; other site
632292005089	S13e-L30e interaction site [polypeptide binding]; other site
632292005090	25S rRNA binding site [nucleotide binding]; other site
632292005091	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
632292005092	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
632292005093	active site
632292005094	Riboflavin kinase; Region: Flavokinase; pfam01687
632292005095	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
632292005096	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
632292005097	RNA binding site [nucleotide binding]; other site
632292005098	active site
632292005099	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
632292005100	DHH family; Region: DHH; pfam01368
632292005101	DHHA1 domain; Region: DHHA1; pfam02272
632292005102	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
632292005103	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
632292005104	translation initiation factor IF-2; Region: IF-2; TIGR00487
632292005105	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
632292005106	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
632292005107	G1 box; other site
632292005108	putative GEF interaction site [polypeptide binding]; other site
632292005109	GTP/Mg2+ binding site [chemical binding]; other site
632292005110	Switch I region; other site
632292005111	G2 box; other site
632292005112	G3 box; other site
632292005113	Switch II region; other site
632292005114	G4 box; other site
632292005115	G5 box; other site
632292005116	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
632292005117	Translation-initiation factor 2; Region: IF-2; pfam11987
632292005118	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
632292005119	Protein of unknown function (DUF448); Region: DUF448; pfam04296
632292005120	putative RNA binding cleft [nucleotide binding]; other site
632292005121	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
632292005122	NusA N-terminal domain; Region: NusA_N; pfam08529
632292005123	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
632292005124	RNA binding site [nucleotide binding]; other site
632292005125	homodimer interface [polypeptide binding]; other site
632292005126	NusA-like KH domain; Region: KH_5; pfam13184
632292005127	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
632292005128	G-X-X-G motif; other site
632292005129	ribosome maturation protein RimP; Reviewed; Region: PRK00092
632292005130	Sm and related proteins; Region: Sm_like; cl00259
632292005131	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
632292005132	putative oligomer interface [polypeptide binding]; other site
632292005133	putative RNA binding site [nucleotide binding]; other site
632292005134	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
632292005135	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
632292005136	substrate binding site [chemical binding]; other site
632292005137	hexamer interface [polypeptide binding]; other site
632292005138	metal binding site [ion binding]; metal-binding site
632292005139	GTPase RsgA; Reviewed; Region: PRK00098
632292005140	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
632292005141	RNA binding site [nucleotide binding]; other site
632292005142	homodimer interface [polypeptide binding]; other site
632292005143	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
632292005144	GTP/Mg2+ binding site [chemical binding]; other site
632292005145	G4 box; other site
632292005146	G5 box; other site
632292005147	G1 box; other site
632292005148	Switch I region; other site
632292005149	G2 box; other site
632292005150	G3 box; other site
632292005151	Switch II region; other site
632292005152	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
632292005153	Catalytic domain of Protein Kinases; Region: PKc; cd00180
632292005154	active site
632292005155	ATP binding site [chemical binding]; other site
632292005156	substrate binding site [chemical binding]; other site
632292005157	activation loop (A-loop); other site
632292005158	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
632292005159	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
632292005160	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
632292005161	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
632292005162	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
632292005163	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
632292005164	Protein phosphatase 2C; Region: PP2C; pfam00481
632292005165	active site
632292005166	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
632292005167	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292005168	FeS/SAM binding site; other site
632292005169	NusB family; Region: NusB; pfam01029
632292005170	16S rRNA methyltransferase B; Provisional; Region: PRK14902
632292005171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292005172	S-adenosylmethionine binding site [chemical binding]; other site
632292005173	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
632292005174	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
632292005175	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
632292005176	putative active site [active]
632292005177	substrate binding site [chemical binding]; other site
632292005178	putative cosubstrate binding site; other site
632292005179	catalytic site [active]
632292005180	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
632292005181	substrate binding site [chemical binding]; other site
632292005182	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
632292005183	active site
632292005184	catalytic residues [active]
632292005185	metal binding site [ion binding]; metal-binding site
632292005186	primosome assembly protein PriA; Validated; Region: PRK05580
632292005187	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292005188	ATP binding site [chemical binding]; other site
632292005189	putative Mg++ binding site [ion binding]; other site
632292005190	helicase superfamily c-terminal domain; Region: HELICc; smart00490
632292005191	ATP-binding site [chemical binding]; other site
632292005192	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
632292005193	Flavoprotein; Region: Flavoprotein; pfam02441
632292005194	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
632292005195	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
632292005196	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
632292005197	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
632292005198	catalytic site [active]
632292005199	G-X2-G-X-G-K; other site
632292005200	hypothetical protein; Provisional; Region: PRK04323
632292005201	hypothetical protein; Provisional; Region: PRK11820
632292005202	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
632292005203	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
632292005204	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
632292005205	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
632292005206	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
632292005207	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
632292005208	active site
632292005209	Zn binding site [ion binding]; other site
632292005210	Protein of unknown function DUF89; Region: DUF89; cl15397
632292005211	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
632292005212	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
632292005213	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292005214	Transposase; Region: DEDD_Tnp_IS110; pfam01548
632292005215	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
632292005216	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
632292005217	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632292005218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292005219	Walker A/P-loop; other site
632292005220	ATP binding site [chemical binding]; other site
632292005221	Q-loop/lid; other site
632292005222	ABC transporter signature motif; other site
632292005223	Walker B; other site
632292005224	D-loop; other site
632292005225	H-loop/switch region; other site
632292005226	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
632292005227	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632292005228	putative active site [active]
632292005229	CoA binding domain; Region: CoA_binding_2; pfam13380
632292005230	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
632292005231	Predicted membrane protein [Function unknown]; Region: COG2323
632292005232	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
632292005233	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
632292005234	acyl-activating enzyme (AAE) consensus motif; other site
632292005235	AMP binding site [chemical binding]; other site
632292005236	active site
632292005237	CoA binding site [chemical binding]; other site
632292005238	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
632292005239	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
632292005240	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632292005241	dimer interface [polypeptide binding]; other site
632292005242	PYR/PP interface [polypeptide binding]; other site
632292005243	TPP binding site [chemical binding]; other site
632292005244	substrate binding site [chemical binding]; other site
632292005245	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
632292005246	TPP-binding site; other site
632292005247	stage V sporulation protein T; Region: spore_V_T; TIGR02851
632292005248	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
632292005249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292005250	putative substrate translocation pore; other site
632292005251	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
632292005252	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
632292005253	substrate binding pocket [chemical binding]; other site
632292005254	chain length determination region; other site
632292005255	substrate-Mg2+ binding site; other site
632292005256	catalytic residues [active]
632292005257	aspartate-rich region 1; other site
632292005258	active site lid residues [active]
632292005259	aspartate-rich region 2; other site
632292005260	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
632292005261	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
632292005262	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
632292005263	generic binding surface II; other site
632292005264	generic binding surface I; other site
632292005265	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
632292005266	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
632292005267	Asp23 family; Region: Asp23; pfam03780
632292005268	Asp23 family; Region: Asp23; pfam03780
632292005269	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
632292005270	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
632292005271	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
632292005272	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
632292005273	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
632292005274	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
632292005275	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
632292005276	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
632292005277	NTPase; Region: NTPase_1; cl17478
632292005278	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
632292005279	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
632292005280	putative active site [active]
632292005281	metal binding site [ion binding]; metal-binding site
632292005282	homodimer binding site [polypeptide binding]; other site
632292005283	phosphodiesterase; Provisional; Region: PRK12704
632292005284	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
632292005285	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292005286	Zn2+ binding site [ion binding]; other site
632292005287	Mg2+ binding site [ion binding]; other site
632292005288	RecX family; Region: RecX; cl00936
632292005289	recombinase A; Provisional; Region: recA; PRK09354
632292005290	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
632292005291	hexamer interface [polypeptide binding]; other site
632292005292	Walker A motif; other site
632292005293	ATP binding site [chemical binding]; other site
632292005294	Walker B motif; other site
632292005295	competence damage-inducible protein A; Provisional; Region: PRK00549
632292005296	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
632292005297	putative MPT binding site; other site
632292005298	Competence-damaged protein; Region: CinA; pfam02464
632292005299	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
632292005300	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
632292005301	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
632292005302	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292005303	FeS/SAM binding site; other site
632292005304	TRAM domain; Region: TRAM; pfam01938
632292005305	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
632292005306	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
632292005307	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
632292005308	homodimer interface [polypeptide binding]; other site
632292005309	NADP binding site [chemical binding]; other site
632292005310	substrate binding site [chemical binding]; other site
632292005311	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
632292005312	hypothetical protein; Provisional; Region: PRK00955
632292005313	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
632292005314	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
632292005315	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
632292005316	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
632292005317	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
632292005318	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
632292005319	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826
632292005320	hypothetical protein; Reviewed; Region: PRK12497
632292005321	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
632292005322	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
632292005323	RNA/DNA hybrid binding site [nucleotide binding]; other site
632292005324	active site
632292005325	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
632292005326	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
632292005327	GTP/Mg2+ binding site [chemical binding]; other site
632292005328	G4 box; other site
632292005329	G5 box; other site
632292005330	G1 box; other site
632292005331	Switch I region; other site
632292005332	G2 box; other site
632292005333	G3 box; other site
632292005334	Switch II region; other site
632292005335	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
632292005336	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
632292005337	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
632292005338	RimM N-terminal domain; Region: RimM; pfam01782
632292005339	PRC-barrel domain; Region: PRC; pfam05239
632292005340	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
632292005341	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
632292005342	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
632292005343	signal recognition particle protein; Provisional; Region: PRK10867
632292005344	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
632292005345	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
632292005346	P loop; other site
632292005347	GTP binding site [chemical binding]; other site
632292005348	Signal peptide binding domain; Region: SRP_SPB; pfam02978
632292005349	putative DNA-binding protein; Validated; Region: PRK00118
632292005350	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
632292005351	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
632292005352	active site
632292005353	HIGH motif; other site
632292005354	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
632292005355	active site
632292005356	KMSKS motif; other site
632292005357	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
632292005358	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
632292005359	NAD binding site [chemical binding]; other site
632292005360	homodimer interface [polypeptide binding]; other site
632292005361	active site
632292005362	substrate binding site [chemical binding]; other site
632292005363	galactokinase; Provisional; Region: PRK05322
632292005364	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
632292005365	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
632292005366	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
632292005367	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
632292005368	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
632292005369	dimer interface [polypeptide binding]; other site
632292005370	active site
632292005371	Sensory domain found in PocR; Region: PocR; pfam10114
632292005372	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
632292005373	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292005374	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292005375	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292005376	Uncharacterized conserved protein [Function unknown]; Region: COG1683
632292005377	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
632292005378	G1 box; other site
632292005379	GTP/Mg2+ binding site [chemical binding]; other site
632292005380	Switch I region; other site
632292005381	G2 box; other site
632292005382	G3 box; other site
632292005383	Switch II region; other site
632292005384	G4 box; other site
632292005385	G5 box; other site
632292005386	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
632292005387	Found in ATP-dependent protease La (LON); Region: LON; smart00464
632292005388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292005389	Walker A motif; other site
632292005390	ATP binding site [chemical binding]; other site
632292005391	Walker B motif; other site
632292005392	arginine finger; other site
632292005393	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
632292005394	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
632292005395	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
632292005396	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
632292005397	hydroxyglutarate oxidase; Provisional; Region: PRK11728
632292005398	Predicted dehydrogenase [General function prediction only]; Region: COG0579
632292005399	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
632292005400	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
632292005401	1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181
632292005402	dimer interface [polypeptide binding]; other site
632292005403	active site
632292005404	metal binding site [ion binding]; metal-binding site
632292005405	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
632292005406	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
632292005407	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292005408	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292005409	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632292005410	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
632292005411	Walker A/P-loop; other site
632292005412	ATP binding site [chemical binding]; other site
632292005413	Q-loop/lid; other site
632292005414	ABC transporter signature motif; other site
632292005415	Walker B; other site
632292005416	D-loop; other site
632292005417	H-loop/switch region; other site
632292005418	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632292005419	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
632292005420	Walker A/P-loop; other site
632292005421	ATP binding site [chemical binding]; other site
632292005422	Q-loop/lid; other site
632292005423	ABC transporter signature motif; other site
632292005424	Walker B; other site
632292005425	D-loop; other site
632292005426	H-loop/switch region; other site
632292005427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292005428	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632292005429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
632292005430	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
632292005431	Walker A motif; other site
632292005432	ATP binding site [chemical binding]; other site
632292005433	Walker B motif; other site
632292005434	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
632292005435	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632292005436	Walker A/P-loop; other site
632292005437	ATP binding site [chemical binding]; other site
632292005438	Q-loop/lid; other site
632292005439	ABC transporter signature motif; other site
632292005440	Walker B; other site
632292005441	D-loop; other site
632292005442	H-loop/switch region; other site
632292005443	MMPL family; Region: MMPL; pfam03176
632292005444	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
632292005445	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
632292005446	active site
632292005447	HIGH motif; other site
632292005448	dimer interface [polypeptide binding]; other site
632292005449	KMSKS motif; other site
632292005450	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632292005451	RNA binding surface [nucleotide binding]; other site
632292005452	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
632292005453	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
632292005454	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
632292005455	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
632292005456	active site
632292005457	putative substrate binding pocket [chemical binding]; other site
632292005458	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
632292005459	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
632292005460	homotetramer interface [polypeptide binding]; other site
632292005461	ligand binding site [chemical binding]; other site
632292005462	catalytic site [active]
632292005463	NAD binding site [chemical binding]; other site
632292005464	replicative DNA helicase; Region: DnaB; TIGR00665
632292005465	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
632292005466	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
632292005467	Walker A motif; other site
632292005468	ATP binding site [chemical binding]; other site
632292005469	Walker B motif; other site
632292005470	DNA binding loops [nucleotide binding]
632292005471	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
632292005472	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
632292005473	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
632292005474	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
632292005475	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
632292005476	DHH family; Region: DHH; pfam01368
632292005477	DHHA1 domain; Region: DHHA1; pfam02272
632292005478	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
632292005479	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
632292005480	Prephenate dehydratase; Region: PDT; pfam00800
632292005481	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
632292005482	putative L-Phe binding site [chemical binding]; other site
632292005483	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
632292005484	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
632292005485	TPP-binding site [chemical binding]; other site
632292005486	putative dimer interface [polypeptide binding]; other site
632292005487	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
632292005488	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632292005489	dimer interface [polypeptide binding]; other site
632292005490	PYR/PP interface [polypeptide binding]; other site
632292005491	TPP binding site [chemical binding]; other site
632292005492	substrate binding site [chemical binding]; other site
632292005493	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
632292005494	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632292005495	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175
632292005496	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
632292005497	Uncharacterized conserved protein [Function unknown]; Region: COG0398
632292005498	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
632292005499	seryl-tRNA synthetase; Provisional; Region: PRK05431
632292005500	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
632292005501	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
632292005502	dimer interface [polypeptide binding]; other site
632292005503	active site
632292005504	motif 1; other site
632292005505	motif 2; other site
632292005506	motif 3; other site
632292005507	Protein of unknown function DUF45; Region: DUF45; pfam01863
632292005508	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
632292005509	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
632292005510	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292005511	ATP binding site [chemical binding]; other site
632292005512	putative Mg++ binding site [ion binding]; other site
632292005513	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
632292005514	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
632292005515	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
632292005516	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
632292005517	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
632292005518	active site
632292005519	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
632292005520	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
632292005521	Walker A/P-loop; other site
632292005522	ATP binding site [chemical binding]; other site
632292005523	Q-loop/lid; other site
632292005524	ABC transporter signature motif; other site
632292005525	Walker B; other site
632292005526	D-loop; other site
632292005527	H-loop/switch region; other site
632292005528	Cobalt transport protein; Region: CbiQ; cl00463
632292005529	PDGLE domain; Region: PDGLE; cl07986
632292005530	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
632292005531	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
632292005532	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632292005533	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
632292005534	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
632292005535	mannonate dehydratase; Provisional; Region: PRK03906
632292005536	mannonate dehydratase; Region: uxuA; TIGR00695
632292005537	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
632292005538	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
632292005539	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
632292005540	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
632292005541	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
632292005542	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
632292005543	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
632292005544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292005545	active site
632292005546	phosphorylation site [posttranslational modification]
632292005547	intermolecular recognition site; other site
632292005548	dimerization interface [polypeptide binding]; other site
632292005549	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292005550	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
632292005551	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
632292005552	Histidine kinase; Region: His_kinase; pfam06580
632292005553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292005554	ATP binding site [chemical binding]; other site
632292005555	Mg2+ binding site [ion binding]; other site
632292005556	G-X-G motif; other site
632292005557	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292005558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292005559	dimer interface [polypeptide binding]; other site
632292005560	ABC-ATPase subunit interface; other site
632292005561	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292005562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292005563	dimer interface [polypeptide binding]; other site
632292005564	conserved gate region; other site
632292005565	ABC-ATPase subunit interface; other site
632292005566	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
632292005567	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292005568	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
632292005569	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292005570	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292005571	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
632292005572	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632292005573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292005574	homodimer interface [polypeptide binding]; other site
632292005575	catalytic residue [active]
632292005576	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
632292005577	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
632292005578	prephenate dehydrogenase; Validated; Region: PRK08507
632292005579	Prephenate dehydrogenase; Region: PDH; pfam02153
632292005580	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
632292005581	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
632292005582	hinge; other site
632292005583	active site
632292005584	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632292005585	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
632292005586	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632292005587	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
632292005588	N- and C-terminal domain interface [polypeptide binding]; other site
632292005589	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
632292005590	active site
632292005591	putative catalytic site [active]
632292005592	metal binding site [ion binding]; metal-binding site
632292005593	ATP binding site [chemical binding]; other site
632292005594	carbohydrate binding site [chemical binding]; other site
632292005595	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
632292005596	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
632292005597	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
632292005598	active site
632292005599	metal binding site [ion binding]; metal-binding site
632292005600	homotetramer interface [polypeptide binding]; other site
632292005601	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
632292005602	active site
632292005603	dimerization interface [polypeptide binding]; other site
632292005604	ribonuclease PH; Reviewed; Region: rph; PRK00173
632292005605	Ribonuclease PH; Region: RNase_PH_bact; cd11362
632292005606	hexamer interface [polypeptide binding]; other site
632292005607	active site
632292005608	Sporulation and spore germination; Region: Germane; smart00909
632292005609	Sporulation and spore germination; Region: Germane; cl11253
632292005610	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
632292005611	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
632292005612	Mg++ binding site [ion binding]; other site
632292005613	putative catalytic motif [active]
632292005614	substrate binding site [chemical binding]; other site
632292005615	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
632292005616	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
632292005617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292005618	S-adenosylmethionine binding site [chemical binding]; other site
632292005619	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632292005620	Coenzyme A binding pocket [chemical binding]; other site
632292005621	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
632292005622	MPT binding site; other site
632292005623	trimer interface [polypeptide binding]; other site
632292005624	molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499
632292005625	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
632292005626	trimer interface [polypeptide binding]; other site
632292005627	dimer interface [polypeptide binding]; other site
632292005628	putative active site [active]
632292005629	MOSC domain; Region: MOSC; pfam03473
632292005630	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292005631	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632292005632	FeS/SAM binding site; other site
632292005633	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
632292005634	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
632292005635	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
632292005636	dimer interface [polypeptide binding]; other site
632292005637	putative functional site; other site
632292005638	putative MPT binding site; other site
632292005639	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
632292005640	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
632292005641	dimer interface [polypeptide binding]; other site
632292005642	putative functional site; other site
632292005643	putative MPT binding site; other site
632292005644	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632292005645	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292005646	Walker A/P-loop; other site
632292005647	ATP binding site [chemical binding]; other site
632292005648	Q-loop/lid; other site
632292005649	ABC transporter signature motif; other site
632292005650	Walker B; other site
632292005651	D-loop; other site
632292005652	H-loop/switch region; other site
632292005653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292005654	dimer interface [polypeptide binding]; other site
632292005655	conserved gate region; other site
632292005656	putative PBP binding loops; other site
632292005657	ABC-ATPase subunit interface; other site
632292005658	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
632292005659	PBP superfamily domain; Region: PBP_like_2; pfam12849
632292005660	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292005661	hypothetical protein; Provisional; Region: PRK08328
632292005662	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
632292005663	ATP binding site [chemical binding]; other site
632292005664	substrate interface [chemical binding]; other site
632292005665	Ubiquitin-like proteins; Region: UBQ; cl00155
632292005666	charged pocket; other site
632292005667	hydrophobic patch; other site
632292005668	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
632292005669	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
632292005670	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
632292005671	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
632292005672	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
632292005673	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
632292005674	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
632292005675	hypothetical protein; Validated; Region: PRK00110
632292005676	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
632292005677	stage V sporulation protein B; Region: spore_V_B; TIGR02900
632292005678	Uncharacterized conserved protein [Function unknown]; Region: COG1739
632292005679	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
632292005680	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
632292005681	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
632292005682	active site
632292005683	Ap6A binding site [chemical binding]; other site
632292005684	nudix motif; other site
632292005685	metal binding site [ion binding]; metal-binding site
632292005686	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
632292005687	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
632292005688	HflX GTPase family; Region: HflX; cd01878
632292005689	G1 box; other site
632292005690	GTP/Mg2+ binding site [chemical binding]; other site
632292005691	Switch I region; other site
632292005692	G2 box; other site
632292005693	G3 box; other site
632292005694	Switch II region; other site
632292005695	G4 box; other site
632292005696	G5 box; other site
632292005697	elongation factor Tu; Reviewed; Region: PRK00049
632292005698	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
632292005699	G1 box; other site
632292005700	GEF interaction site [polypeptide binding]; other site
632292005701	GTP/Mg2+ binding site [chemical binding]; other site
632292005702	Switch I region; other site
632292005703	G2 box; other site
632292005704	G3 box; other site
632292005705	Switch II region; other site
632292005706	G4 box; other site
632292005707	G5 box; other site
632292005708	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
632292005709	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
632292005710	Antibiotic Binding Site [chemical binding]; other site
632292005711	elongation factor G; Reviewed; Region: PRK00007
632292005712	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
632292005713	G1 box; other site
632292005714	putative GEF interaction site [polypeptide binding]; other site
632292005715	GTP/Mg2+ binding site [chemical binding]; other site
632292005716	Switch I region; other site
632292005717	G2 box; other site
632292005718	G3 box; other site
632292005719	Switch II region; other site
632292005720	G4 box; other site
632292005721	G5 box; other site
632292005722	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
632292005723	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
632292005724	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
632292005725	30S ribosomal protein S7; Validated; Region: PRK05302
632292005726	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
632292005727	S17 interaction site [polypeptide binding]; other site
632292005728	S8 interaction site; other site
632292005729	16S rRNA interaction site [nucleotide binding]; other site
632292005730	streptomycin interaction site [chemical binding]; other site
632292005731	23S rRNA interaction site [nucleotide binding]; other site
632292005732	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
632292005733	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
632292005734	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
632292005735	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
632292005736	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
632292005737	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
632292005738	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
632292005739	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
632292005740	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
632292005741	G-loop; other site
632292005742	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
632292005743	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
632292005744	DNA binding site [nucleotide binding]
632292005745	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
632292005746	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
632292005747	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
632292005748	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
632292005749	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
632292005750	RPB1 interaction site [polypeptide binding]; other site
632292005751	RPB10 interaction site [polypeptide binding]; other site
632292005752	RPB11 interaction site [polypeptide binding]; other site
632292005753	RPB3 interaction site [polypeptide binding]; other site
632292005754	RPB12 interaction site [polypeptide binding]; other site
632292005755	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
632292005756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292005757	active site
632292005758	phosphorylation site [posttranslational modification]
632292005759	intermolecular recognition site; other site
632292005760	CheB methylesterase; Region: CheB_methylest; pfam01339
632292005761	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
632292005762	active site
632292005763	metal binding site [ion binding]; metal-binding site
632292005764	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
632292005765	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
632292005766	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
632292005767	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
632292005768	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
632292005769	active site
632292005770	dimer interface [polypeptide binding]; other site
632292005771	motif 1; other site
632292005772	motif 2; other site
632292005773	motif 3; other site
632292005774	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
632292005775	anticodon binding site; other site
632292005776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632292005777	binding surface
632292005778	TPR repeat; Region: TPR_11; pfam13414
632292005779	TPR motif; other site
632292005780	Tetratricopeptide repeat; Region: TPR_16; pfam13432
632292005781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632292005782	binding surface
632292005783	TPR repeat; Region: TPR_11; pfam13414
632292005784	TPR motif; other site
632292005785	Divergent AAA domain; Region: AAA_4; pfam04326
632292005786	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
632292005787	CHASE4 domain; Region: CHASE4; pfam05228
632292005788	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632292005789	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292005790	Zn2+ binding site [ion binding]; other site
632292005791	Mg2+ binding site [ion binding]; other site
632292005792	Peptidase family M23; Region: Peptidase_M23; pfam01551
632292005793	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
632292005794	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
632292005795	ScpA/B protein; Region: ScpA_ScpB; cl00598
632292005796	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
632292005797	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
632292005798	active site
632292005799	HIGH motif; other site
632292005800	dimer interface [polypeptide binding]; other site
632292005801	KMSKS motif; other site
632292005802	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
632292005803	Peptidase family M50; Region: Peptidase_M50; pfam02163
632292005804	active site
632292005805	putative substrate binding region [chemical binding]; other site
632292005806	diaminopimelate decarboxylase; Region: lysA; TIGR01048
632292005807	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
632292005808	active site
632292005809	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
632292005810	substrate binding site [chemical binding]; other site
632292005811	catalytic residues [active]
632292005812	dimer interface [polypeptide binding]; other site
632292005813	AMP-binding domain protein; Validated; Region: PRK08315
632292005814	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
632292005815	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
632292005816	acyl-activating enzyme (AAE) consensus motif; other site
632292005817	putative AMP binding site [chemical binding]; other site
632292005818	putative active site [active]
632292005819	putative CoA binding site [chemical binding]; other site
632292005820	sporulation sigma factor SigG; Reviewed; Region: PRK08215
632292005821	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292005822	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
632292005823	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292005824	DNA binding residues [nucleotide binding]
632292005825	sporulation sigma factor SigE; Reviewed; Region: PRK08301
632292005826	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292005827	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292005828	DNA binding residues [nucleotide binding]
632292005829	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
632292005830	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
632292005831	Domain of unknown function (DUF303); Region: DUF303; pfam03629
632292005832	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632292005833	Domain of unknown function (DUF303); Region: DUF303; pfam03629
632292005834	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
632292005835	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
632292005836	putative active site [active]
632292005837	putative metal binding site [ion binding]; other site
632292005838	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
632292005839	cell division protein FtsZ; Validated; Region: PRK09330
632292005840	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
632292005841	nucleotide binding site [chemical binding]; other site
632292005842	SulA interaction site; other site
632292005843	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
632292005844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
632292005845	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
632292005846	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
632292005847	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
632292005848	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
632292005849	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
632292005850	hinge; other site
632292005851	active site
632292005852	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
632292005853	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
632292005854	active site
632292005855	homodimer interface [polypeptide binding]; other site
632292005856	cell division protein FtsW; Region: ftsW; TIGR02614
632292005857	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
632292005858	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
632292005859	NAD binding site [chemical binding]; other site
632292005860	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632292005861	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632292005862	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
632292005863	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
632292005864	Mg++ binding site [ion binding]; other site
632292005865	putative catalytic motif [active]
632292005866	putative substrate binding site [chemical binding]; other site
632292005867	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
632292005868	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
632292005869	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632292005870	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632292005871	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
632292005872	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
632292005873	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632292005874	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632292005875	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
632292005876	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
632292005877	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
632292005878	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
632292005879	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
632292005880	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
632292005881	Cell division protein FtsL; Region: FtsL; cl11433
632292005882	MraW methylase family; Region: Methyltransf_5; pfam01795
632292005883	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
632292005884	cell division protein MraZ; Reviewed; Region: PRK00326
632292005885	MraZ protein; Region: MraZ; pfam02381
632292005886	MraZ protein; Region: MraZ; pfam02381
632292005887	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
632292005888	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
632292005889	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
632292005890	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
632292005891	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
632292005892	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
632292005893	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
632292005894	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632292005895	active site
632292005896	NTP binding site [chemical binding]; other site
632292005897	metal binding triad [ion binding]; metal-binding site
632292005898	antibiotic binding site [chemical binding]; other site
632292005899	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
632292005900	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
632292005901	GatB domain; Region: GatB_Yqey; smart00845
632292005902	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
632292005903	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
632292005904	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
632292005905	Transposase domain (DUF772); Region: DUF772; pfam05598
632292005906	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
632292005907	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
632292005908	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632292005909	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
632292005910	Walker A/P-loop; other site
632292005911	ATP binding site [chemical binding]; other site
632292005912	Q-loop/lid; other site
632292005913	ABC transporter signature motif; other site
632292005914	Walker B; other site
632292005915	D-loop; other site
632292005916	H-loop/switch region; other site
632292005917	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
632292005918	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
632292005919	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
632292005920	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
632292005921	dimerization interface [polypeptide binding]; other site
632292005922	domain crossover interface; other site
632292005923	redox-dependent activation switch; other site
632292005924	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
632292005925	DNA-binding site [nucleotide binding]; DNA binding site
632292005926	RNA-binding motif; other site
632292005927	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
632292005928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292005929	S-adenosylmethionine binding site [chemical binding]; other site
632292005930	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
632292005931	GTP-binding protein Der; Reviewed; Region: PRK00093
632292005932	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
632292005933	G1 box; other site
632292005934	GTP/Mg2+ binding site [chemical binding]; other site
632292005935	Switch I region; other site
632292005936	G2 box; other site
632292005937	Switch II region; other site
632292005938	G3 box; other site
632292005939	G4 box; other site
632292005940	G5 box; other site
632292005941	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
632292005942	G1 box; other site
632292005943	GTP/Mg2+ binding site [chemical binding]; other site
632292005944	Switch I region; other site
632292005945	G2 box; other site
632292005946	G3 box; other site
632292005947	Switch II region; other site
632292005948	G4 box; other site
632292005949	G5 box; other site
632292005950	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
632292005951	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
632292005952	Protein of unknown function (DUF512); Region: DUF512; pfam04459
632292005953	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
632292005954	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
632292005955	substrate binding pocket [chemical binding]; other site
632292005956	dimer interface [polypeptide binding]; other site
632292005957	inhibitor binding site; inhibition site
632292005958	Protein of unknown function (DUF402); Region: DUF402; pfam04167
632292005959	sporulation sigma factor SigK; Reviewed; Region: PRK05803
632292005960	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292005961	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292005962	DNA binding residues [nucleotide binding]
632292005963	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
632292005964	Peptidase family U32; Region: Peptidase_U32; pfam01136
632292005965	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
632292005966	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292005967	S-adenosylmethionine binding site [chemical binding]; other site
632292005968	YceG-like family; Region: YceG; pfam02618
632292005969	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
632292005970	dimerization interface [polypeptide binding]; other site
632292005971	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
632292005972	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
632292005973	G1 box; other site
632292005974	putative GEF interaction site [polypeptide binding]; other site
632292005975	GTP/Mg2+ binding site [chemical binding]; other site
632292005976	Switch I region; other site
632292005977	G2 box; other site
632292005978	G3 box; other site
632292005979	Switch II region; other site
632292005980	G4 box; other site
632292005981	G5 box; other site
632292005982	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
632292005983	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
632292005984	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
632292005985	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
632292005986	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292005987	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292005988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292005989	dimer interface [polypeptide binding]; other site
632292005990	conserved gate region; other site
632292005991	putative PBP binding loops; other site
632292005992	ABC-ATPase subunit interface; other site
632292005993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292005994	dimer interface [polypeptide binding]; other site
632292005995	conserved gate region; other site
632292005996	putative PBP binding loops; other site
632292005997	ABC-ATPase subunit interface; other site
632292005998	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
632292005999	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
632292006000	active site
632292006001	catalytic site [active]
632292006002	metal binding site [ion binding]; metal-binding site
632292006003	dimer interface [polypeptide binding]; other site
632292006004	Transposase domain (DUF772); Region: DUF772; pfam05598
632292006005	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
632292006006	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
632292006007	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
632292006008	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
632292006009	active site
632292006010	metal binding site [ion binding]; metal-binding site
632292006011	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
632292006012	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
632292006013	active site
632292006014	metal binding site [ion binding]; metal-binding site
632292006015	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
632292006016	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
632292006017	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
632292006018	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
632292006019	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292006020	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
632292006021	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292006022	DNA binding residues [nucleotide binding]
632292006023	DNA primase; Validated; Region: dnaG; PRK05667
632292006024	CHC2 zinc finger; Region: zf-CHC2; pfam01807
632292006025	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
632292006026	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
632292006027	active site
632292006028	metal binding site [ion binding]; metal-binding site
632292006029	interdomain interaction site; other site
632292006030	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
632292006031	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
632292006032	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292006033	Zn2+ binding site [ion binding]; other site
632292006034	Mg2+ binding site [ion binding]; other site
632292006035	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
632292006036	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
632292006037	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
632292006038	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292006039	Walker A motif; other site
632292006040	ATP binding site [chemical binding]; other site
632292006041	Walker B motif; other site
632292006042	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
632292006043	Clp protease; Region: CLP_protease; pfam00574
632292006044	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
632292006045	oligomer interface [polypeptide binding]; other site
632292006046	active site residues [active]
632292006047	trigger factor; Provisional; Region: tig; PRK01490
632292006048	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
632292006049	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
632292006050	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
632292006051	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
632292006052	hexamer (dimer of trimers) interface [polypeptide binding]; other site
632292006053	substrate binding site [chemical binding]; other site
632292006054	trimer interface [polypeptide binding]; other site
632292006055	Mn binding site [ion binding]; other site
632292006056	L-rhamnose isomerase; Provisional; Region: PRK01076
632292006057	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
632292006058	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632292006059	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
632292006060	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632292006061	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
632292006062	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
632292006063	tetramer interface [polypeptide binding]; other site
632292006064	TPP-binding site [chemical binding]; other site
632292006065	heterodimer interface [polypeptide binding]; other site
632292006066	phosphorylation loop region [posttranslational modification]
632292006067	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
632292006068	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
632292006069	alpha subunit interface [polypeptide binding]; other site
632292006070	TPP binding site [chemical binding]; other site
632292006071	heterodimer interface [polypeptide binding]; other site
632292006072	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
632292006073	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
632292006074	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
632292006075	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632292006076	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
632292006077	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
632292006078	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
632292006079	E3 interaction surface; other site
632292006080	lipoyl attachment site [posttranslational modification]; other site
632292006081	e3 binding domain; Region: E3_binding; pfam02817
632292006082	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
632292006083	lipoyl synthase; Provisional; Region: PRK05481
632292006084	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292006085	FeS/SAM binding site; other site
632292006086	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
632292006087	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
632292006088	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
632292006089	putative NAD(P) binding site [chemical binding]; other site
632292006090	catalytic Zn binding site [ion binding]; other site
632292006091	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
632292006092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632292006093	NAD(P) binding site [chemical binding]; other site
632292006094	active site
632292006095	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
632292006096	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632292006097	active site
632292006098	Uncharacterized conserved protein [Function unknown]; Region: COG3347
632292006099	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
632292006100	intersubunit interface [polypeptide binding]; other site
632292006101	active site
632292006102	Zn2+ binding site [ion binding]; other site
632292006103	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
632292006104	intersubunit interface [polypeptide binding]; other site
632292006105	active site
632292006106	Zn2+ binding site [ion binding]; other site
632292006107	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
632292006108	intersubunit interface [polypeptide binding]; other site
632292006109	active site
632292006110	Zn2+ binding site [ion binding]; other site
632292006111	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
632292006112	Uncharacterized conserved protein [Function unknown]; Region: COG1615
632292006113	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
632292006114	Protein of unknown function (DUF964); Region: DUF964; pfam06133
632292006115	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
632292006116	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
632292006117	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
632292006118	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
632292006119	DHH family; Region: DHH; pfam01368
632292006120	DHHA1 domain; Region: DHHA1; pfam02272
632292006121	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
632292006122	S-adenosylmethionine synthetase; Validated; Region: PRK05250
632292006123	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
632292006124	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
632292006125	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
632292006126	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
632292006127	putative active site [active]
632292006128	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
632292006129	HAMP domain; Region: HAMP; pfam00672
632292006130	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632292006131	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292006132	dimer interface [polypeptide binding]; other site
632292006133	putative CheW interface [polypeptide binding]; other site
632292006134	Uncharacterized conserved protein [Function unknown]; Region: COG0432
632292006135	Domain of unknown function (DUF377); Region: DUF377; pfam04041
632292006136	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
632292006137	active site
632292006138	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
632292006139	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
632292006140	PYR/PP interface [polypeptide binding]; other site
632292006141	dimer interface [polypeptide binding]; other site
632292006142	TPP binding site [chemical binding]; other site
632292006143	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
632292006144	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
632292006145	TPP-binding site [chemical binding]; other site
632292006146	dimer interface [polypeptide binding]; other site
632292006147	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
632292006148	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
632292006149	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
632292006150	homodimer interface [polypeptide binding]; other site
632292006151	substrate-cofactor binding pocket; other site
632292006152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292006153	catalytic residue [active]
632292006154	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
632292006155	metal binding site [ion binding]; metal-binding site
632292006156	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
632292006157	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
632292006158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
632292006159	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
632292006160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
632292006161	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
632292006162	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
632292006163	dimer interface [polypeptide binding]; other site
632292006164	putative anticodon binding site; other site
632292006165	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
632292006166	motif 1; other site
632292006167	active site
632292006168	motif 2; other site
632292006169	motif 3; other site
632292006170	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
632292006171	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
632292006172	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
632292006173	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
632292006174	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
632292006175	MgtE intracellular N domain; Region: MgtE_N; pfam03448
632292006176	FOG: CBS domain [General function prediction only]; Region: COG0517
632292006177	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
632292006178	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
632292006179	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
632292006180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292006181	catalytic residue [active]
632292006182	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
632292006183	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
632292006184	CoA binding domain; Region: CoA_binding; smart00881
632292006185	hypothetical protein; Provisional; Region: PRK08582
632292006186	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
632292006187	RNA binding site [nucleotide binding]; other site
632292006188	Septum formation initiator; Region: DivIC; cl17659
632292006189	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801
632292006190	YabP family; Region: YabP; cl06766
632292006191	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632292006192	RNA binding surface [nucleotide binding]; other site
632292006193	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
632292006194	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
632292006195	IHF dimer interface [polypeptide binding]; other site
632292006196	IHF - DNA interface [nucleotide binding]; other site
632292006197	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
632292006198	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
632292006199	homodimer interface [polypeptide binding]; other site
632292006200	metal binding site [ion binding]; metal-binding site
632292006201	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
632292006202	homodimer interface [polypeptide binding]; other site
632292006203	active site
632292006204	putative chemical substrate binding site [chemical binding]; other site
632292006205	metal binding site [ion binding]; metal-binding site
632292006206	Stage III sporulation protein D; Region: SpoIIID; pfam12116
632292006207	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
632292006208	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
632292006209	FAD binding pocket [chemical binding]; other site
632292006210	FAD binding motif [chemical binding]; other site
632292006211	phosphate binding motif [ion binding]; other site
632292006212	beta-alpha-beta structure motif; other site
632292006213	NAD binding pocket [chemical binding]; other site
632292006214	Iron coordination center [ion binding]; other site
632292006215	putative oxidoreductase; Provisional; Region: PRK12831
632292006216	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632292006217	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
632292006218	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
632292006219	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
632292006220	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
632292006221	FtsH Extracellular; Region: FtsH_ext; pfam06480
632292006222	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
632292006223	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292006224	Walker A motif; other site
632292006225	ATP binding site [chemical binding]; other site
632292006226	Walker B motif; other site
632292006227	arginine finger; other site
632292006228	Peptidase family M41; Region: Peptidase_M41; pfam01434
632292006229	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292006230	active site
632292006231	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
632292006232	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
632292006233	Ligand Binding Site [chemical binding]; other site
632292006234	TilS substrate C-terminal domain; Region: TilS_C; cl17443
632292006235	SurA N-terminal domain; Region: SurA_N_3; cl07813
632292006236	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
632292006237	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
632292006238	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
632292006239	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292006240	ATP binding site [chemical binding]; other site
632292006241	putative Mg++ binding site [ion binding]; other site
632292006242	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632292006243	nucleotide binding region [chemical binding]; other site
632292006244	ATP-binding site [chemical binding]; other site
632292006245	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
632292006246	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
632292006247	putative active site [active]
632292006248	catalytic residue [active]
632292006249	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
632292006250	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
632292006251	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292006252	active site
632292006253	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
632292006254	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
632292006255	Substrate binding site; other site
632292006256	Mg++ binding site; other site
632292006257	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
632292006258	active site
632292006259	substrate binding site [chemical binding]; other site
632292006260	CoA binding site [chemical binding]; other site
632292006261	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
632292006262	catalytic motif [active]
632292006263	Zn binding site [ion binding]; other site
632292006264	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292006265	active site
632292006266	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
632292006267	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
632292006268	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
632292006269	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
632292006270	hinge; other site
632292006271	active site
632292006272	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
632292006273	Predicted amidohydrolase [General function prediction only]; Region: COG0388
632292006274	active site
632292006275	catalytic triad [active]
632292006276	dimer interface [polypeptide binding]; other site
632292006277	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
632292006278	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
632292006279	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632292006280	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
632292006281	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
632292006282	Protein export membrane protein; Region: SecD_SecF; pfam02355
632292006283	protein-export membrane protein SecD; Region: secD; TIGR01129
632292006284	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
632292006285	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
632292006286	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
632292006287	trimer interface [polypeptide binding]; other site
632292006288	putative metal binding site [ion binding]; other site
632292006289	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
632292006290	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292006291	FeS/SAM binding site; other site
632292006292	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
632292006293	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
632292006294	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
632292006295	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
632292006296	intersubunit interface [polypeptide binding]; other site
632292006297	active site
632292006298	zinc binding site [ion binding]; other site
632292006299	Na+ binding site [ion binding]; other site
632292006300	putative hydrolase; Validated; Region: PRK09248
632292006301	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
632292006302	active site
632292006303	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
632292006304	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
632292006305	dimer interface [polypeptide binding]; other site
632292006306	active site
632292006307	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
632292006308	dimer interface [polypeptide binding]; other site
632292006309	active site
632292006310	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632292006311	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632292006312	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
632292006313	Transcriptional regulators [Transcription]; Region: MarR; COG1846
632292006314	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
632292006315	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
632292006316	ROK family; Region: ROK; pfam00480
632292006317	nucleotide binding site [chemical binding]; other site
632292006318	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292006319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006320	dimer interface [polypeptide binding]; other site
632292006321	conserved gate region; other site
632292006322	putative PBP binding loops; other site
632292006323	ABC-ATPase subunit interface; other site
632292006324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006325	dimer interface [polypeptide binding]; other site
632292006326	conserved gate region; other site
632292006327	putative PBP binding loops; other site
632292006328	ABC-ATPase subunit interface; other site
632292006329	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292006330	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292006331	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
632292006332	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
632292006333	minor groove reading motif; other site
632292006334	helix-hairpin-helix signature motif; other site
632292006335	substrate binding pocket [chemical binding]; other site
632292006336	active site
632292006337	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
632292006338	carbohydrate binding site [chemical binding]; other site
632292006339	pullulanase, type I; Region: pulA_typeI; TIGR02104
632292006340	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
632292006341	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
632292006342	Ca binding site [ion binding]; other site
632292006343	active site
632292006344	catalytic site [active]
632292006345	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
632292006346	Starch binding domain; Region: CBM_2; smart01065
632292006347	starch-binding site 2 [chemical binding]; other site
632292006348	starch-binding site 1 [chemical binding]; other site
632292006349	S-layer homology domain; Region: SLH; pfam00395
632292006350	S-layer homology domain; Region: SLH; pfam00395
632292006351	S-layer homology domain; Region: SLH; pfam00395
632292006352	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632292006353	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632292006354	sugar binding site [chemical binding]; other site
632292006355	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
632292006356	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
632292006357	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
632292006358	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292006359	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
632292006360	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292006361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006362	dimer interface [polypeptide binding]; other site
632292006363	conserved gate region; other site
632292006364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
632292006365	ABC-ATPase subunit interface; other site
632292006366	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292006367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006368	dimer interface [polypeptide binding]; other site
632292006369	conserved gate region; other site
632292006370	ABC-ATPase subunit interface; other site
632292006371	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632292006372	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292006373	dimerization interface [polypeptide binding]; other site
632292006374	Histidine kinase; Region: His_kinase; pfam06580
632292006375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292006376	ATP binding site [chemical binding]; other site
632292006377	Mg2+ binding site [ion binding]; other site
632292006378	G-X-G motif; other site
632292006379	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
632292006380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292006381	active site
632292006382	phosphorylation site [posttranslational modification]
632292006383	intermolecular recognition site; other site
632292006384	dimerization interface [polypeptide binding]; other site
632292006385	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292006386	MarR family; Region: MarR_2; cl17246
632292006387	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
632292006388	active site
632292006389	metal binding site [ion binding]; metal-binding site
632292006390	xylose isomerase; Provisional; Region: PRK05474
632292006391	xylose isomerase; Region: xylose_isom_A; TIGR02630
632292006392	Helix-turn-helix domain; Region: HTH_17; pfam12728
632292006393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292006394	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632292006395	putative substrate translocation pore; other site
632292006396	Response regulator receiver domain; Region: Response_reg; pfam00072
632292006397	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292006398	active site
632292006399	phosphorylation site [posttranslational modification]
632292006400	intermolecular recognition site; other site
632292006401	dimerization interface [polypeptide binding]; other site
632292006402	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292006403	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292006404	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292006405	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632292006406	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292006407	dimerization interface [polypeptide binding]; other site
632292006408	Histidine kinase; Region: His_kinase; pfam06580
632292006409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292006410	ATP binding site [chemical binding]; other site
632292006411	Mg2+ binding site [ion binding]; other site
632292006412	G-X-G motif; other site
632292006413	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292006414	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292006415	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292006416	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
632292006417	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292006418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006419	putative PBP binding loops; other site
632292006420	dimer interface [polypeptide binding]; other site
632292006421	ABC-ATPase subunit interface; other site
632292006422	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292006423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006424	dimer interface [polypeptide binding]; other site
632292006425	conserved gate region; other site
632292006426	ABC-ATPase subunit interface; other site
632292006427	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
632292006428	Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424
632292006429	S-layer homology domain; Region: SLH; pfam00395
632292006430	S-layer homology domain; Region: SLH; pfam00395
632292006431	S-layer homology domain; Region: SLH; pfam00395
632292006432	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
632292006433	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
632292006434	dimer interface [polypeptide binding]; other site
632292006435	anticodon binding site; other site
632292006436	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
632292006437	homodimer interface [polypeptide binding]; other site
632292006438	motif 1; other site
632292006439	active site
632292006440	motif 2; other site
632292006441	GAD domain; Region: GAD; pfam02938
632292006442	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
632292006443	motif 3; other site
632292006444	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
632292006445	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
632292006446	dimer interface [polypeptide binding]; other site
632292006447	motif 1; other site
632292006448	active site
632292006449	motif 2; other site
632292006450	motif 3; other site
632292006451	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
632292006452	anticodon binding site; other site
632292006453	CrcB-like protein; Region: CRCB; pfam02537
632292006454	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
632292006455	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
632292006456	Cation efflux family; Region: Cation_efflux; pfam01545
632292006457	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292006458	active site
632292006459	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
632292006460	prolyl-tRNA synthetase; Provisional; Region: PRK09194
632292006461	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
632292006462	dimer interface [polypeptide binding]; other site
632292006463	motif 1; other site
632292006464	active site
632292006465	motif 2; other site
632292006466	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
632292006467	putative deacylase active site [active]
632292006468	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
632292006469	active site
632292006470	motif 3; other site
632292006471	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
632292006472	anticodon binding site; other site
632292006473	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
632292006474	Mechanosensitive ion channel; Region: MS_channel; pfam00924
632292006475	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
632292006476	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
632292006477	catalytic triad [active]
632292006478	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
632292006479	ANTAR domain; Region: ANTAR; pfam03861
632292006480	GAF domain; Region: GAF_3; pfam13492
632292006481	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632292006482	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292006483	Zn2+ binding site [ion binding]; other site
632292006484	Mg2+ binding site [ion binding]; other site
632292006485	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
632292006486	N- and C-terminal domain interface [polypeptide binding]; other site
632292006487	D-xylulose kinase; Region: XylB; TIGR01312
632292006488	active site
632292006489	MgATP binding site [chemical binding]; other site
632292006490	catalytic site [active]
632292006491	metal binding site [ion binding]; metal-binding site
632292006492	xylulose binding site [chemical binding]; other site
632292006493	homodimer interface [polypeptide binding]; other site
632292006494	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292006495	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292006496	DNA binding site [nucleotide binding]
632292006497	domain linker motif; other site
632292006498	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
632292006499	dimerization interface [polypeptide binding]; other site
632292006500	ligand binding site [chemical binding]; other site
632292006501	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
632292006502	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
632292006503	catalytic motif [active]
632292006504	Zn binding site [ion binding]; other site
632292006505	RibD C-terminal domain; Region: RibD_C; cl17279
632292006506	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
632292006507	Lumazine binding domain; Region: Lum_binding; pfam00677
632292006508	Lumazine binding domain; Region: Lum_binding; pfam00677
632292006509	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
632292006510	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
632292006511	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
632292006512	dimerization interface [polypeptide binding]; other site
632292006513	active site
632292006514	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
632292006515	homopentamer interface [polypeptide binding]; other site
632292006516	active site
632292006517	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
632292006518	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632292006519	Bacterial SH3 domain; Region: SH3_3; cl17532
632292006520	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632292006521	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632292006522	Probable transposase; Region: OrfB_IS605; pfam01385
632292006523	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632292006524	Response regulator receiver domain; Region: Response_reg; pfam00072
632292006525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292006526	active site
632292006527	phosphorylation site [posttranslational modification]
632292006528	intermolecular recognition site; other site
632292006529	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632292006530	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292006531	Zn2+ binding site [ion binding]; other site
632292006532	Mg2+ binding site [ion binding]; other site
632292006533	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292006534	Zn2+ binding site [ion binding]; other site
632292006535	Mg2+ binding site [ion binding]; other site
632292006536	hypothetical protein; Reviewed; Region: PRK00024
632292006537	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
632292006538	MPN+ (JAMM) motif; other site
632292006539	Zinc-binding site [ion binding]; other site
632292006540	glycogen branching enzyme; Provisional; Region: PRK12313
632292006541	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
632292006542	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
632292006543	active site
632292006544	catalytic site [active]
632292006545	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
632292006546	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
632292006547	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
632292006548	ligand binding site; other site
632292006549	oligomer interface; other site
632292006550	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
632292006551	dimer interface [polypeptide binding]; other site
632292006552	N-terminal domain interface [polypeptide binding]; other site
632292006553	sulfate 1 binding site; other site
632292006554	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
632292006555	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
632292006556	ligand binding site; other site
632292006557	oligomer interface; other site
632292006558	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
632292006559	dimer interface [polypeptide binding]; other site
632292006560	N-terminal domain interface [polypeptide binding]; other site
632292006561	sulfate 1 binding site; other site
632292006562	glycogen synthase; Provisional; Region: glgA; PRK00654
632292006563	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
632292006564	ADP-binding pocket [chemical binding]; other site
632292006565	homodimer interface [polypeptide binding]; other site
632292006566	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
632292006567	homodimer interface [polypeptide binding]; other site
632292006568	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
632292006569	active site pocket [active]
632292006570	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
632292006571	active site
632292006572	catalytic triad [active]
632292006573	oxyanion hole [active]
632292006574	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
632292006575	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
632292006576	nucleotide binding site [chemical binding]; other site
632292006577	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632292006578	Probable transposase; Region: OrfB_IS605; pfam01385
632292006579	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632292006580	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
632292006581	ATP cone domain; Region: ATP-cone; pfam03477
632292006582	Class III ribonucleotide reductase; Region: RNR_III; cd01675
632292006583	effector binding site; other site
632292006584	active site
632292006585	Zn binding site [ion binding]; other site
632292006586	glycine loop; other site
632292006587	4Fe-4S binding domain; Region: Fer4_5; pfam12801
632292006588	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632292006589	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
632292006590	aspartate aminotransferase; Provisional; Region: PRK06290
632292006591	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632292006592	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632292006593	homodimer interface [polypeptide binding]; other site
632292006594	catalytic residue [active]
632292006595	hypothetical protein; Provisional; Region: PRK02877
632292006596	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
632292006597	nucleotide binding site [chemical binding]; other site
632292006598	Type III pantothenate kinase; Region: Pan_kinase; cl17198
632292006599	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
632292006600	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
632292006601	substrate binding site [chemical binding]; other site
632292006602	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
632292006603	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
632292006604	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
632292006605	substrate binding site [chemical binding]; other site
632292006606	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
632292006607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292006608	ATP binding site [chemical binding]; other site
632292006609	Mg2+ binding site [ion binding]; other site
632292006610	G-X-G motif; other site
632292006611	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
632292006612	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
632292006613	putative NAD(P) binding site [chemical binding]; other site
632292006614	catalytic Zn binding site [ion binding]; other site
632292006615	Domain of unknown function (DUF377); Region: DUF377; pfam04041
632292006616	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
632292006617	active site
632292006618	Domain of unknown function (DUF348); Region: DUF348; pfam03990
632292006619	Domain of unknown function (DUF348); Region: DUF348; pfam03990
632292006620	G5 domain; Region: G5; pfam07501
632292006621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
632292006622	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
632292006623	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
632292006624	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
632292006625	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632292006626	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
632292006627	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
632292006628	active site residue [active]
632292006629	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
632292006630	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
632292006631	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
632292006632	active site
632292006633	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632292006634	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632292006635	metal binding site [ion binding]; metal-binding site
632292006636	active site
632292006637	I-site; other site
632292006638	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632292006639	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
632292006640	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
632292006641	ATP-grasp domain; Region: ATP-grasp_4; cl17255
632292006642	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632292006643	Transcriptional regulators [Transcription]; Region: GntR; COG1802
632292006644	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292006645	DNA-binding site [nucleotide binding]; DNA binding site
632292006646	FCD domain; Region: FCD; pfam07729
632292006647	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
632292006648	isocitrate dehydrogenase; Validated; Region: PRK06451
632292006649	aconitate hydratase; Validated; Region: PRK07229
632292006650	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
632292006651	substrate binding site [chemical binding]; other site
632292006652	ligand binding site [chemical binding]; other site
632292006653	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
632292006654	substrate binding site [chemical binding]; other site
632292006655	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
632292006656	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
632292006657	putative ligand binding site [chemical binding]; other site
632292006658	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
632292006659	active site
632292006660	catalytic residues [active]
632292006661	metal binding site [ion binding]; metal-binding site
632292006662	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
632292006663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006664	dimer interface [polypeptide binding]; other site
632292006665	conserved gate region; other site
632292006666	putative PBP binding loops; other site
632292006667	ABC-ATPase subunit interface; other site
632292006668	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
632292006669	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
632292006670	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
632292006671	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
632292006672	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632292006673	FeS/SAM binding site; other site
632292006674	Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967
632292006675	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
632292006676	Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia.  This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965
632292006677	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
632292006678	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
632292006679	Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967
632292006680	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292006681	Transposase; Region: DEDD_Tnp_IS110; pfam01548
632292006682	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
632292006683	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
632292006684	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
632292006685	Nitrogen regulatory protein P-II; Region: P-II; smart00938
632292006686	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
632292006687	Nitrogen regulatory protein P-II; Region: P-II; smart00938
632292006688	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
632292006689	nitrogenase iron protein; Region: nifH; TIGR01287
632292006690	Nucleotide-binding sites [chemical binding]; other site
632292006691	Walker A motif; other site
632292006692	Switch I region of nucleotide binding site; other site
632292006693	Fe4S4 binding sites [ion binding]; other site
632292006694	Switch II region of nucleotide binding site; other site
632292006695	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
632292006696	Nitrogen regulatory protein P-II; Region: P-II; smart00938
632292006697	ammonium transporter; Region: amt; TIGR00836
632292006698	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292006699	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
632292006700	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
632292006701	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
632292006702	active site
632292006703	catalytic residues [active]
632292006704	metal binding site [ion binding]; metal-binding site
632292006705	RmuC family; Region: RmuC; pfam02646
632292006706	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
632292006707	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632292006708	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
632292006709	Walker A motif; other site
632292006710	ATP binding site [chemical binding]; other site
632292006711	Walker B motif; other site
632292006712	Protein of unknown function (DUF327); Region: DUF327; pfam03885
632292006713	Protein of unknown function (DUF970); Region: DUF970; pfam06153
632292006714	thymidylate kinase; Validated; Region: tmk; PRK00698
632292006715	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
632292006716	TMP-binding site; other site
632292006717	ATP-binding site [chemical binding]; other site
632292006718	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
632292006719	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
632292006720	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
632292006721	catalytic residue [active]
632292006722	Fumarase C-terminus; Region: Fumerase_C; pfam05683
632292006723	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632292006724	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
632292006725	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632292006726	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
632292006727	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
632292006728	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
632292006729	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
632292006730	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
632292006731	active site
632292006732	catalytic residues [active]
632292006733	metal binding site [ion binding]; metal-binding site
632292006734	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
632292006735	2-isopropylmalate synthase; Validated; Region: PRK00915
632292006736	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
632292006737	active site
632292006738	catalytic residues [active]
632292006739	metal binding site [ion binding]; metal-binding site
632292006740	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
632292006741	ketol-acid reductoisomerase; Provisional; Region: PRK05479
632292006742	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
632292006743	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
632292006744	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
632292006745	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
632292006746	putative valine binding site [chemical binding]; other site
632292006747	dimer interface [polypeptide binding]; other site
632292006748	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
632292006749	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
632292006750	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
632292006751	PYR/PP interface [polypeptide binding]; other site
632292006752	dimer interface [polypeptide binding]; other site
632292006753	TPP binding site [chemical binding]; other site
632292006754	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
632292006755	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
632292006756	TPP-binding site [chemical binding]; other site
632292006757	dimer interface [polypeptide binding]; other site
632292006758	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
632292006759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632292006760	NAD(P) binding site [chemical binding]; other site
632292006761	active site
632292006762	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
632292006763	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
632292006764	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
632292006765	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
632292006766	active site
632292006767	Uncharacterized conserved protein [Function unknown]; Region: COG1633
632292006768	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
632292006769	diiron binding motif [ion binding]; other site
632292006770	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
632292006771	Aspartase; Region: Aspartase; cd01357
632292006772	active sites [active]
632292006773	tetramer interface [polypeptide binding]; other site
632292006774	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
632292006775	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
632292006776	G1 box; other site
632292006777	GTP/Mg2+ binding site [chemical binding]; other site
632292006778	Switch I region; other site
632292006779	G2 box; other site
632292006780	Switch II region; other site
632292006781	G3 box; other site
632292006782	G4 box; other site
632292006783	G5 box; other site
632292006784	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
632292006785	Predicted acetyltransferase [General function prediction only]; Region: COG3393
632292006786	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
632292006787	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
632292006788	HTH domain; Region: HTH_11; pfam08279
632292006789	3H domain; Region: 3H; pfam02829
632292006790	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
632292006791	Melibiase; Region: Melibiase; pfam02065
632292006792	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
632292006793	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
632292006794	substrate binding [chemical binding]; other site
632292006795	active site
632292006796	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292006797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006798	dimer interface [polypeptide binding]; other site
632292006799	conserved gate region; other site
632292006800	putative PBP binding loops; other site
632292006801	ABC-ATPase subunit interface; other site
632292006802	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
632292006803	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006804	dimer interface [polypeptide binding]; other site
632292006805	conserved gate region; other site
632292006806	putative PBP binding loops; other site
632292006807	ABC-ATPase subunit interface; other site
632292006808	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292006809	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292006810	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292006811	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292006812	DNA binding site [nucleotide binding]
632292006813	domain linker motif; other site
632292006814	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
632292006815	dimerization interface [polypeptide binding]; other site
632292006816	ligand binding site [chemical binding]; other site
632292006817	sodium binding site [ion binding]; other site
632292006818	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
632292006819	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632292006820	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292006821	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
632292006822	Walker A/P-loop; other site
632292006823	ATP binding site [chemical binding]; other site
632292006824	Q-loop/lid; other site
632292006825	ABC transporter signature motif; other site
632292006826	Walker B; other site
632292006827	D-loop; other site
632292006828	H-loop/switch region; other site
632292006829	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
632292006830	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632292006831	active site
632292006832	catalytic tetrad [active]
632292006833	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632292006834	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
632292006835	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
632292006836	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632292006837	ATP binding site [chemical binding]; other site
632292006838	putative Mg++ binding site [ion binding]; other site
632292006839	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632292006840	nucleotide binding region [chemical binding]; other site
632292006841	ATP-binding site [chemical binding]; other site
632292006842	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632292006843	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
632292006844	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632292006845	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
632292006846	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
632292006847	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292006848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006849	dimer interface [polypeptide binding]; other site
632292006850	conserved gate region; other site
632292006851	putative PBP binding loops; other site
632292006852	ABC-ATPase subunit interface; other site
632292006853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006854	dimer interface [polypeptide binding]; other site
632292006855	conserved gate region; other site
632292006856	putative PBP binding loops; other site
632292006857	ABC-ATPase subunit interface; other site
632292006858	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292006859	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292006860	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
632292006861	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
632292006862	inhibitor site; inhibition site
632292006863	active site
632292006864	dimer interface [polypeptide binding]; other site
632292006865	catalytic residue [active]
632292006866	Transcriptional regulators [Transcription]; Region: FadR; COG2186
632292006867	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292006868	DNA-binding site [nucleotide binding]; DNA binding site
632292006869	FCD domain; Region: FCD; pfam07729
632292006870	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
632292006871	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
632292006872	inhibitor site; inhibition site
632292006873	active site
632292006874	dimer interface [polypeptide binding]; other site
632292006875	catalytic residue [active]
632292006876	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
632292006877	SmpB-tmRNA interface; other site
632292006878	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
632292006879	Bacterial sugar transferase; Region: Bac_transf; pfam02397
632292006880	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
632292006881	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292006882	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
632292006883	N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754
632292006884	catalytic domain interface [polypeptide binding]; other site
632292006885	homodimer interface [polypeptide binding]; other site
632292006886	putative active site [active]
632292006887	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
632292006888	catalytic domain interface [polypeptide binding]; other site
632292006889	putative homodimer interface [polypeptide binding]; other site
632292006890	Protein of unknown function, DUF608; Region: DUF608; pfam04685
632292006891	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
632292006892	beta-galactosidase; Region: BGL; TIGR03356
632292006893	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
632292006894	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
632292006895	DNA binding site [nucleotide binding]
632292006896	active site
632292006897	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
632292006898	TRAM domain; Region: TRAM; cl01282
632292006899	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
632292006900	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292006901	S-adenosylmethionine binding site [chemical binding]; other site
632292006902	Hemerythrin; Region: Hemerythrin; cd12107
632292006903	Fe binding site [ion binding]; other site
632292006904	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
632292006905	Protein of unknown function DUF58; Region: DUF58; pfam01882
632292006906	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
632292006907	pullulanase, type I; Region: pulA_typeI; TIGR02104
632292006908	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
632292006909	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
632292006910	Ca binding site [ion binding]; other site
632292006911	active site
632292006912	catalytic site [active]
632292006913	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
632292006914	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632292006915	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632292006916	metal binding site [ion binding]; metal-binding site
632292006917	active site
632292006918	I-site; other site
632292006919	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
632292006920	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
632292006921	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632292006922	Coenzyme A binding pocket [chemical binding]; other site
632292006923	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
632292006924	Glycoprotease family; Region: Peptidase_M22; pfam00814
632292006925	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
632292006926	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
632292006927	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
632292006928	active site
632292006929	putative GTP cyclohydrolase; Provisional; Region: PRK13674
632292006930	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
632292006931	active site
632292006932	S-layer homology domain; Region: SLH; pfam00395
632292006933	S-layer homology domain; Region: SLH; pfam00395
632292006934	Bacterial Ig-like domain; Region: Big_5; pfam13205
632292006935	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
632292006936	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292006937	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
632292006938	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292006939	DNA binding residues [nucleotide binding]
632292006940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
632292006941	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
632292006942	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
632292006943	anti sigma factor interaction site; other site
632292006944	regulatory phosphorylation site [posttranslational modification]; other site
632292006945	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
632292006946	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632292006947	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632292006948	DNA binding residues [nucleotide binding]
632292006949	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
632292006950	dipeptidase PepV; Reviewed; Region: PRK07318
632292006951	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
632292006952	active site
632292006953	metal binding site [ion binding]; metal-binding site
632292006954	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
632292006955	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
632292006956	active site
632292006957	metal binding site [ion binding]; metal-binding site
632292006958	Uncharacterized conserved protein [Function unknown]; Region: COG0398
632292006959	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
632292006960	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
632292006961	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
632292006962	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
632292006963	Domain of unknown function DUF20; Region: UPF0118; pfam01594
632292006964	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
632292006965	Peptidase family U32; Region: Peptidase_U32; pfam01136
632292006966	Collagenase; Region: DUF3656; pfam12392
632292006967	Peptidase family U32; Region: Peptidase_U32; cl03113
632292006968	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
632292006969	Cell division protein ZapA; Region: ZapA; pfam05164
632292006970	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632292006971	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
632292006972	active site
632292006973	catalytic tetrad [active]
632292006974	Rubrerythrin [Energy production and conversion]; Region: COG1592
632292006975	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
632292006976	binuclear metal center [ion binding]; other site
632292006977	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
632292006978	iron binding site [ion binding]; other site
632292006979	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292006980	Uncharacterized conserved protein [Function unknown]; Region: COG3461
632292006981	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
632292006982	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
632292006983	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
632292006984	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
632292006985	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292006986	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292006987	DNA binding site [nucleotide binding]
632292006988	domain linker motif; other site
632292006989	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
632292006990	ligand binding site [chemical binding]; other site
632292006991	dimerization interface [polypeptide binding]; other site
632292006992	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292006993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292006994	dimer interface [polypeptide binding]; other site
632292006995	conserved gate region; other site
632292006996	putative PBP binding loops; other site
632292006997	ABC-ATPase subunit interface; other site
632292006998	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
632292006999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007000	putative PBP binding loops; other site
632292007001	dimer interface [polypeptide binding]; other site
632292007002	ABC-ATPase subunit interface; other site
632292007003	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292007004	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292007005	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
632292007006	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
632292007007	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
632292007008	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
632292007009	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292007010	motif II; other site
632292007011	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; pfam09560
632292007012	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
632292007013	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
632292007014	Substrate binding site; other site
632292007015	Cupin domain; Region: Cupin_2; cl17218
632292007016	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
632292007017	active site
632292007018	substrate-binding site [chemical binding]; other site
632292007019	metal-binding site [ion binding]
632292007020	GTP binding site [chemical binding]; other site
632292007021	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
632292007022	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292007023	S-adenosylmethionine binding site [chemical binding]; other site
632292007024	Preprotein translocase subunit; Region: YajC; pfam02699
632292007025	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292007026	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632292007027	FeS/SAM binding site; other site
632292007028	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
632292007029	Predicted membrane protein [Function unknown]; Region: COG2246
632292007030	GtrA-like protein; Region: GtrA; pfam04138
632292007031	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
632292007032	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
632292007033	Ligand binding site; other site
632292007034	Putative Catalytic site; other site
632292007035	DXD motif; other site
632292007036	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
632292007037	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
632292007038	Walker A/P-loop; other site
632292007039	ATP binding site [chemical binding]; other site
632292007040	Q-loop/lid; other site
632292007041	ABC transporter signature motif; other site
632292007042	Walker B; other site
632292007043	D-loop; other site
632292007044	H-loop/switch region; other site
632292007045	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
632292007046	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
632292007047	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
632292007048	Walker A/P-loop; other site
632292007049	ATP binding site [chemical binding]; other site
632292007050	Q-loop/lid; other site
632292007051	ABC transporter signature motif; other site
632292007052	Walker B; other site
632292007053	D-loop; other site
632292007054	H-loop/switch region; other site
632292007055	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
632292007056	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
632292007057	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
632292007058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007059	dimer interface [polypeptide binding]; other site
632292007060	conserved gate region; other site
632292007061	putative PBP binding loops; other site
632292007062	ABC-ATPase subunit interface; other site
632292007063	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
632292007064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007065	dimer interface [polypeptide binding]; other site
632292007066	conserved gate region; other site
632292007067	putative PBP binding loops; other site
632292007068	ABC-ATPase subunit interface; other site
632292007069	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
632292007070	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
632292007071	substrate binding site [chemical binding]; other site
632292007072	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292007073	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292007074	DNA binding site [nucleotide binding]
632292007075	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
632292007076	Domain of unknown function (DUF377); Region: DUF377; pfam04041
632292007077	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
632292007078	active site
632292007079	Domain of unknown function (DUF377); Region: DUF377; pfam04041
632292007080	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
632292007081	active site
632292007082	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
632292007083	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
632292007084	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
632292007085	dimer interface [polypeptide binding]; other site
632292007086	substrate binding site [chemical binding]; other site
632292007087	ATP binding site [chemical binding]; other site
632292007088	ThiC family; Region: ThiC; pfam01964
632292007089	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
632292007090	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
632292007091	thiamine phosphate binding site [chemical binding]; other site
632292007092	active site
632292007093	pyrophosphate binding site [ion binding]; other site
632292007094	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
632292007095	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
632292007096	ATP binding site [chemical binding]; other site
632292007097	substrate interface [chemical binding]; other site
632292007098	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
632292007099	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292007100	FeS/SAM binding site; other site
632292007101	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
632292007102	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
632292007103	ThiS interaction site; other site
632292007104	putative active site [active]
632292007105	tetramer interface [polypeptide binding]; other site
632292007106	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
632292007107	thiS-thiF/thiG interaction site; other site
632292007108	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632292007109	Predicted transcriptional regulators [Transcription]; Region: COG1725
632292007110	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292007111	DNA-binding site [nucleotide binding]; DNA binding site
632292007112	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
632292007113	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
632292007114	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
632292007115	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
632292007116	Hpr binding site; other site
632292007117	active site
632292007118	homohexamer subunit interaction site [polypeptide binding]; other site
632292007119	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
632292007120	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
632292007121	GIY-YIG motif/motif A; other site
632292007122	active site
632292007123	catalytic site [active]
632292007124	putative DNA binding site [nucleotide binding]; other site
632292007125	metal binding site [ion binding]; metal-binding site
632292007126	UvrB/uvrC motif; Region: UVR; pfam02151
632292007127	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
632292007128	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
632292007129	YbbR-like protein; Region: YbbR; pfam07949
632292007130	Uncharacterized conserved protein [Function unknown]; Region: COG1624
632292007131	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
632292007132	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
632292007133	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292007134	FeS/SAM binding site; other site
632292007135	hypothetical protein; Provisional; Region: PRK03881
632292007136	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
632292007137	AMMECR1; Region: AMMECR1; pfam01871
632292007138	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
632292007139	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
632292007140	AP (apurinic/apyrimidinic) site pocket; other site
632292007141	DNA interaction; other site
632292007142	Metal-binding active site; metal-binding site
632292007143	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632292007144	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632292007145	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
632292007146	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292007147	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292007148	DNA binding site [nucleotide binding]
632292007149	domain linker motif; other site
632292007150	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
632292007151	dimerization interface [polypeptide binding]; other site
632292007152	ligand binding site [chemical binding]; other site
632292007153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292007154	putative substrate translocation pore; other site
632292007155	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632292007156	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
632292007157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292007158	FeS/SAM binding site; other site
632292007159	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
632292007160	Family description; Region: UvrD_C_2; pfam13538
632292007161	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
632292007162	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
632292007163	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
632292007164	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
632292007165	FAD binding site [chemical binding]; other site
632292007166	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
632292007167	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
632292007168	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292007169	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
632292007170	regulatory protein interface [polypeptide binding]; other site
632292007171	active site
632292007172	regulatory phosphorylation site [posttranslational modification]; other site
632292007173	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
632292007174	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
632292007175	Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048
632292007176	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
632292007177	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
632292007178	phosphate binding site [ion binding]; other site
632292007179	putative substrate binding pocket [chemical binding]; other site
632292007180	dimer interface [polypeptide binding]; other site
632292007181	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
632292007182	shikimate kinase; Reviewed; Region: aroK; PRK00131
632292007183	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
632292007184	FAD binding domain; Region: FAD_binding_4; pfam01565
632292007185	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
632292007186	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
632292007187	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
632292007188	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292007189	active site
632292007190	motif I; other site
632292007191	motif II; other site
632292007192	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292007193	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
632292007194	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292007195	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292007196	dimerization interface [polypeptide binding]; other site
632292007197	putative DNA binding site [nucleotide binding]; other site
632292007198	putative Zn2+ binding site [ion binding]; other site
632292007199	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
632292007200	Heavy-metal-associated domain; Region: HMA; pfam00403
632292007201	metal-binding site [ion binding]
632292007202	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
632292007203	Soluble P-type ATPase [General function prediction only]; Region: COG4087
632292007204	Bifunctional nuclease; Region: DNase-RNase; pfam02577
632292007205	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
632292007206	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
632292007207	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292007208	FeS/SAM binding site; other site
632292007209	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
632292007210	active site
632292007211	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
632292007212	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
632292007213	active site
632292007214	HIGH motif; other site
632292007215	KMSKS motif; other site
632292007216	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
632292007217	tRNA binding surface [nucleotide binding]; other site
632292007218	anticodon binding site; other site
632292007219	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
632292007220	dimer interface [polypeptide binding]; other site
632292007221	putative tRNA-binding site [nucleotide binding]; other site
632292007222	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
632292007223	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
632292007224	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
632292007225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292007226	active site
632292007227	phosphorylation site [posttranslational modification]
632292007228	intermolecular recognition site; other site
632292007229	dimerization interface [polypeptide binding]; other site
632292007230	CheB methylesterase; Region: CheB_methylest; pfam01339
632292007231	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
632292007232	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
632292007233	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
632292007234	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
632292007235	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
632292007236	homodimer interaction site [polypeptide binding]; other site
632292007237	cofactor binding site; other site
632292007238	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
632292007239	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
632292007240	Walker A/P-loop; other site
632292007241	ATP binding site [chemical binding]; other site
632292007242	Q-loop/lid; other site
632292007243	ABC transporter signature motif; other site
632292007244	Walker B; other site
632292007245	D-loop; other site
632292007246	H-loop/switch region; other site
632292007247	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
632292007248	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
632292007249	dimer interface [polypeptide binding]; other site
632292007250	putative PBP binding regions; other site
632292007251	ABC-ATPase subunit  interface; other site
632292007252	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
632292007253	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
632292007254	putative metal binding site [ion binding]; other site
632292007255	Methyltransferase domain; Region: Methyltransf_31; pfam13847
632292007256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292007257	S-adenosylmethionine binding site [chemical binding]; other site
632292007258	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632292007259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292007260	active site
632292007261	phosphorylation site [posttranslational modification]
632292007262	intermolecular recognition site; other site
632292007263	dimerization interface [polypeptide binding]; other site
632292007264	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632292007265	DNA binding site [nucleotide binding]
632292007266	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292007267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632292007268	dimerization interface [polypeptide binding]; other site
632292007269	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632292007270	dimer interface [polypeptide binding]; other site
632292007271	phosphorylation site [posttranslational modification]
632292007272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292007273	ATP binding site [chemical binding]; other site
632292007274	Mg2+ binding site [ion binding]; other site
632292007275	G-X-G motif; other site
632292007276	Methyltransferase domain; Region: Methyltransf_31; pfam13847
632292007277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292007278	S-adenosylmethionine binding site [chemical binding]; other site
632292007279	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
632292007280	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
632292007281	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
632292007282	substrate binding pocket [chemical binding]; other site
632292007283	catalytic triad [active]
632292007284	Transposase domain (DUF772); Region: DUF772; pfam05598
632292007285	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292007286	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
632292007287	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292007288	dimer interface [polypeptide binding]; other site
632292007289	putative CheW interface [polypeptide binding]; other site
632292007290	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632292007291	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
632292007292	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
632292007293	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632292007294	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
632292007295	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
632292007296	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632292007297	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292007298	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632292007299	TM-ABC transporter signature motif; other site
632292007300	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
632292007301	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
632292007302	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632292007303	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632292007304	TM-ABC transporter signature motif; other site
632292007305	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
632292007306	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632292007307	Walker A/P-loop; other site
632292007308	ATP binding site [chemical binding]; other site
632292007309	Q-loop/lid; other site
632292007310	ABC transporter signature motif; other site
632292007311	Walker B; other site
632292007312	D-loop; other site
632292007313	H-loop/switch region; other site
632292007314	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632292007315	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
632292007316	beta-galactosidase; Region: BGL; TIGR03356
632292007317	Cupin domain; Region: Cupin_2; cl17218
632292007318	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632292007319	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292007320	Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796
632292007321	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
632292007322	active site
632292007323	metal binding site [ion binding]; metal-binding site
632292007324	TIGR02680 family protein; Region: TIGR02680
632292007325	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
632292007326	Protein of unknown function (DUF2398); Region: DUF2398; pfam09661
632292007327	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
632292007328	TIGR02677 family protein; Region: TIGR02677
632292007329	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
632292007330	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
632292007331	Stage II sporulation protein; Region: SpoIID; pfam08486
632292007332	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
632292007333	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
632292007334	TrkA-N domain; Region: TrkA_N; pfam02254
632292007335	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
632292007336	TrkA-N domain; Region: TrkA_N; pfam02254
632292007337	TrkA-C domain; Region: TrkA_C; pfam02080
632292007338	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
632292007339	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
632292007340	Predicted integral membrane protein [Function unknown]; Region: COG5652
632292007341	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632292007342	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292007343	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292007344	Walker A/P-loop; other site
632292007345	ATP binding site [chemical binding]; other site
632292007346	Q-loop/lid; other site
632292007347	ABC transporter signature motif; other site
632292007348	Walker B; other site
632292007349	D-loop; other site
632292007350	H-loop/switch region; other site
632292007351	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
632292007352	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
632292007353	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
632292007354	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
632292007355	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
632292007356	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
632292007357	active site
632292007358	Substrate binding site; other site
632292007359	Mg++ binding site; other site
632292007360	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
632292007361	putative trimer interface [polypeptide binding]; other site
632292007362	putative CoA binding site [chemical binding]; other site
632292007363	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
632292007364	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
632292007365	active site
632292007366	metal binding site [ion binding]; metal-binding site
632292007367	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632292007368	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
632292007369	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
632292007370	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
632292007371	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
632292007372	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
632292007373	active site
632292007374	catalytic site [active]
632292007375	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
632292007376	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
632292007377	Walker A/P-loop; other site
632292007378	ATP binding site [chemical binding]; other site
632292007379	Q-loop/lid; other site
632292007380	ABC transporter signature motif; other site
632292007381	Walker B; other site
632292007382	D-loop; other site
632292007383	H-loop/switch region; other site
632292007384	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
632292007385	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
632292007386	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
632292007387	Walker A/P-loop; other site
632292007388	ATP binding site [chemical binding]; other site
632292007389	Q-loop/lid; other site
632292007390	ABC transporter signature motif; other site
632292007391	Walker B; other site
632292007392	D-loop; other site
632292007393	H-loop/switch region; other site
632292007394	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
632292007395	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
632292007396	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
632292007397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007398	dimer interface [polypeptide binding]; other site
632292007399	conserved gate region; other site
632292007400	putative PBP binding loops; other site
632292007401	ABC-ATPase subunit interface; other site
632292007402	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
632292007403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007404	putative PBP binding loops; other site
632292007405	dimer interface [polypeptide binding]; other site
632292007406	ABC-ATPase subunit interface; other site
632292007407	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
632292007408	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
632292007409	substrate binding site [chemical binding]; other site
632292007410	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
632292007411	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292007412	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292007413	DNA binding site [nucleotide binding]
632292007414	domain linker motif; other site
632292007415	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
632292007416	dimerization interface [polypeptide binding]; other site
632292007417	ligand binding site [chemical binding]; other site
632292007418	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632292007419	sugar binding site [chemical binding]; other site
632292007420	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
632292007421	putative metal binding site [ion binding]; other site
632292007422	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
632292007423	putative metal binding site [ion binding]; other site
632292007424	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
632292007425	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
632292007426	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
632292007427	DNA binding residues [nucleotide binding]
632292007428	dimerization interface [polypeptide binding]; other site
632292007429	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292007430	dimerization interface [polypeptide binding]; other site
632292007431	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632292007432	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292007433	dimer interface [polypeptide binding]; other site
632292007434	putative CheW interface [polypeptide binding]; other site
632292007435	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
632292007436	putative metal binding site [ion binding]; other site
632292007437	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
632292007438	putative metal binding site [ion binding]; other site
632292007439	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
632292007440	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632292007441	Interdomain contacts; other site
632292007442	S-layer homology domain; Region: SLH; pfam00395
632292007443	S-layer homology domain; Region: SLH; pfam00395
632292007444	S-layer homology domain; Region: SLH; pfam00395
632292007445	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
632292007446	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632292007447	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
632292007448	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
632292007449	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292007450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007451	dimer interface [polypeptide binding]; other site
632292007452	conserved gate region; other site
632292007453	putative PBP binding loops; other site
632292007454	ABC-ATPase subunit interface; other site
632292007455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007456	dimer interface [polypeptide binding]; other site
632292007457	conserved gate region; other site
632292007458	putative PBP binding loops; other site
632292007459	ABC-ATPase subunit interface; other site
632292007460	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292007461	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292007462	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
632292007463	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292007464	dimerization interface [polypeptide binding]; other site
632292007465	Histidine kinase; Region: His_kinase; pfam06580
632292007466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292007467	ATP binding site [chemical binding]; other site
632292007468	Mg2+ binding site [ion binding]; other site
632292007469	G-X-G motif; other site
632292007470	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
632292007471	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292007472	active site
632292007473	phosphorylation site [posttranslational modification]
632292007474	intermolecular recognition site; other site
632292007475	dimerization interface [polypeptide binding]; other site
632292007476	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292007477	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292007478	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
632292007479	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
632292007480	active site
632292007481	FMN binding site [chemical binding]; other site
632292007482	substrate binding site [chemical binding]; other site
632292007483	putative catalytic residue [active]
632292007484	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
632292007485	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
632292007486	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632292007487	Transcriptional regulator [Transcription]; Region: LysR; COG0583
632292007488	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
632292007489	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
632292007490	dimerization interface [polypeptide binding]; other site
632292007491	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632292007492	active site
632292007493	NTP binding site [chemical binding]; other site
632292007494	metal binding triad [ion binding]; metal-binding site
632292007495	antibiotic binding site [chemical binding]; other site
632292007496	Uncharacterized conserved protein [Function unknown]; Region: COG2445
632292007497	NAD synthetase; Provisional; Region: PRK13981
632292007498	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
632292007499	multimer interface [polypeptide binding]; other site
632292007500	active site
632292007501	catalytic triad [active]
632292007502	protein interface 1 [polypeptide binding]; other site
632292007503	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
632292007504	homodimer interface [polypeptide binding]; other site
632292007505	NAD binding pocket [chemical binding]; other site
632292007506	ATP binding pocket [chemical binding]; other site
632292007507	Mg binding site [ion binding]; other site
632292007508	active-site loop [active]
632292007509	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
632292007510	stage II sporulation protein D; Region: spore_II_D; TIGR02870
632292007511	Stage II sporulation protein; Region: SpoIID; pfam08486
632292007512	stage II sporulation protein E; Region: spore_II_E; TIGR02865
632292007513	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
632292007514	phage shock protein A; Region: phageshock_pspA; TIGR02977
632292007515	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632292007516	putative active site [active]
632292007517	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
632292007518	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632292007519	NAD(P) binding site [chemical binding]; other site
632292007520	active site
632292007521	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
632292007522	catalytic center binding site [active]
632292007523	ATP binding site [chemical binding]; other site
632292007524	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
632292007525	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
632292007526	dihydropteroate synthase; Region: DHPS; TIGR01496
632292007527	substrate binding pocket [chemical binding]; other site
632292007528	dimer interface [polypeptide binding]; other site
632292007529	inhibitor binding site; inhibition site
632292007530	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292007531	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
632292007532	dimerization interface [polypeptide binding]; other site
632292007533	putative DNA binding site [nucleotide binding]; other site
632292007534	putative Zn2+ binding site [ion binding]; other site
632292007535	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
632292007536	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
632292007537	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
632292007538	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
632292007539	hinge; other site
632292007540	active site
632292007541	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632292007542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292007543	dimer interface [polypeptide binding]; other site
632292007544	putative CheW interface [polypeptide binding]; other site
632292007545	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
632292007546	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
632292007547	TMP-binding site; other site
632292007548	ATP-binding site [chemical binding]; other site
632292007549	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
632292007550	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
632292007551	TMP-binding site; other site
632292007552	ATP-binding site [chemical binding]; other site
632292007553	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
632292007554	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
632292007555	nucleotide binding site [chemical binding]; other site
632292007556	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632292007557	Zn2+ binding site [ion binding]; other site
632292007558	Mg2+ binding site [ion binding]; other site
632292007559	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
632292007560	FOG: CBS domain [General function prediction only]; Region: COG0517
632292007561	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
632292007562	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632292007563	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632292007564	metal binding site [ion binding]; metal-binding site
632292007565	active site
632292007566	I-site; other site
632292007567	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
632292007568	PhoU domain; Region: PhoU; pfam01895
632292007569	PhoU domain; Region: PhoU; pfam01895
632292007570	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
632292007571	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
632292007572	Walker A/P-loop; other site
632292007573	ATP binding site [chemical binding]; other site
632292007574	Q-loop/lid; other site
632292007575	ABC transporter signature motif; other site
632292007576	Walker B; other site
632292007577	D-loop; other site
632292007578	H-loop/switch region; other site
632292007579	PemK-like protein; Region: PemK; pfam02452
632292007580	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
632292007581	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
632292007582	trimer interface [polypeptide binding]; other site
632292007583	putative Zn binding site [ion binding]; other site
632292007584	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632292007585	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292007586	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
632292007587	Walker A/P-loop; other site
632292007588	ATP binding site [chemical binding]; other site
632292007589	Q-loop/lid; other site
632292007590	ABC transporter signature motif; other site
632292007591	Walker B; other site
632292007592	D-loop; other site
632292007593	H-loop/switch region; other site
632292007594	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292007595	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
632292007596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292007597	Walker A/P-loop; other site
632292007598	ATP binding site [chemical binding]; other site
632292007599	Q-loop/lid; other site
632292007600	ABC transporter signature motif; other site
632292007601	Walker B; other site
632292007602	D-loop; other site
632292007603	H-loop/switch region; other site
632292007604	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
632292007605	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292007606	putative DNA binding site [nucleotide binding]; other site
632292007607	putative Zn2+ binding site [ion binding]; other site
632292007608	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
632292007609	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
632292007610	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
632292007611	nucleotide binding site [chemical binding]; other site
632292007612	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
632292007613	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
632292007614	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
632292007615	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
632292007616	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
632292007617	putative active site [active]
632292007618	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
632292007619	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292007620	FeS/SAM binding site; other site
632292007621	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
632292007622	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
632292007623	Ligand Binding Site [chemical binding]; other site
632292007624	TIGR00269 family protein; Region: TIGR00269
632292007625	Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104
632292007626	charged pocket; other site
632292007627	hydrophobic patch; other site
632292007628	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
632292007629	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
632292007630	homotrimer interaction site [polypeptide binding]; other site
632292007631	putative active site [active]
632292007632	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
632292007633	Ligand Binding Site [chemical binding]; other site
632292007634	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
632292007635	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632292007636	G5 domain; Region: G5; pfam07501
632292007637	Peptidase family M23; Region: Peptidase_M23; pfam01551
632292007638	Carbohydrate binding module 27; Region: CBM27; pfam09212
632292007639	Carbohydrate binding module 27; Region: CBM27; pfam09212
632292007640	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
632292007641	putative metal binding site [ion binding]; other site
632292007642	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
632292007643	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
632292007644	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292007645	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292007646	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007647	dimer interface [polypeptide binding]; other site
632292007648	conserved gate region; other site
632292007649	putative PBP binding loops; other site
632292007650	ABC-ATPase subunit interface; other site
632292007651	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292007652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
632292007653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007654	ABC-ATPase subunit interface; other site
632292007655	putative PBP binding loops; other site
632292007656	Uncharacterized conserved protein [Function unknown]; Region: COG3391
632292007657	NHL repeat; Region: NHL; pfam01436
632292007658	Tetratricopeptide repeat; Region: TPR_16; pfam13432
632292007659	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632292007660	TPR motif; other site
632292007661	binding surface
632292007662	Yip1 domain; Region: Yip1; pfam04893
632292007663	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632292007664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007665	dimer interface [polypeptide binding]; other site
632292007666	conserved gate region; other site
632292007667	putative PBP binding loops; other site
632292007668	ABC-ATPase subunit interface; other site
632292007669	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632292007670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632292007671	dimer interface [polypeptide binding]; other site
632292007672	conserved gate region; other site
632292007673	putative PBP binding loops; other site
632292007674	ABC-ATPase subunit interface; other site
632292007675	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
632292007676	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
632292007677	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632292007678	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632292007679	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632292007680	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632292007681	DNA binding site [nucleotide binding]
632292007682	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
632292007683	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
632292007684	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
632292007685	Predicted methyltransferases [General function prediction only]; Region: COG0313
632292007686	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
632292007687	putative SAM binding site [chemical binding]; other site
632292007688	putative homodimer interface [polypeptide binding]; other site
632292007689	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
632292007690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632292007691	S-adenosylmethionine binding site [chemical binding]; other site
632292007692	Response regulator receiver domain; Region: Response_reg; pfam00072
632292007693	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292007694	active site
632292007695	phosphorylation site [posttranslational modification]
632292007696	intermolecular recognition site; other site
632292007697	dimerization interface [polypeptide binding]; other site
632292007698	Predicted membrane protein [Function unknown]; Region: COG2855
632292007699	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
632292007700	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
632292007701	ligand binding site [chemical binding]; other site
632292007702	NAD binding site [chemical binding]; other site
632292007703	dimerization interface [polypeptide binding]; other site
632292007704	catalytic site [active]
632292007705	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
632292007706	putative L-serine binding site [chemical binding]; other site
632292007707	Transcriptional regulator [Transcription]; Region: LysR; COG0583
632292007708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
632292007709	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
632292007710	putative dimerization interface [polypeptide binding]; other site
632292007711	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
632292007712	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292007713	FeS/SAM binding site; other site
632292007714	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
632292007715	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
632292007716	putative oxidoreductase; Provisional; Region: PRK11445
632292007717	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
632292007718	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
632292007719	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
632292007720	active site
632292007721	membrane protein; Provisional; Region: PRK14404
632292007722	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
632292007723	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
632292007724	Ca binding site [ion binding]; other site
632292007725	active site
632292007726	catalytic site [active]
632292007727	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
632292007728	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
632292007729	metal binding site 2 [ion binding]; metal-binding site
632292007730	putative DNA binding helix; other site
632292007731	metal binding site 1 [ion binding]; metal-binding site
632292007732	dimer interface [polypeptide binding]; other site
632292007733	structural Zn2+ binding site [ion binding]; other site
632292007734	Rubrerythrin [Energy production and conversion]; Region: COG1592
632292007735	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
632292007736	binuclear metal center [ion binding]; other site
632292007737	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
632292007738	iron binding site [ion binding]; other site
632292007739	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
632292007740	DNA methylase; Region: N6_N4_Mtase; pfam01555
632292007741	MjaI restriction endonuclease; Region: RE_MjaI; pfam09568
632292007742	Short C-terminal domain; Region: SHOCT; pfam09851
632292007743	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
632292007744	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
632292007745	Domain of unknown function (DUF202); Region: DUF202; cl09954
632292007746	Transposase; Region: DEDD_Tnp_IS110; pfam01548
632292007747	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
632292007748	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
632292007749	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
632292007750	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
632292007751	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
632292007752	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
632292007753	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
632292007754	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
632292007755	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
632292007756	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
632292007757	dimerization domain swap beta strand [polypeptide binding]; other site
632292007758	regulatory protein interface [polypeptide binding]; other site
632292007759	active site
632292007760	regulatory phosphorylation site [posttranslational modification]; other site
632292007761	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
632292007762	active site
632292007763	P-loop; other site
632292007764	phosphorylation site [posttranslational modification]
632292007765	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
632292007766	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
632292007767	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
632292007768	active site
632292007769	phosphorylation site [posttranslational modification]
632292007770	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
632292007771	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
632292007772	putative substrate binding site [chemical binding]; other site
632292007773	putative ATP binding site [chemical binding]; other site
632292007774	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632292007775	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632292007776	DNA-binding site [nucleotide binding]; DNA binding site
632292007777	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632292007778	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632292007779	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
632292007780	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
632292007781	putative active site [active]
632292007782	putative metal binding site [ion binding]; other site
632292007783	Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335
632292007784	homodimer interface [polypeptide binding]; other site
632292007785	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
632292007786	active site
632292007787	catalytic site [active]
632292007788	maltose binding site 2 [chemical binding]; other site
632292007789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
632292007790	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cd02106
632292007791	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
632292007792	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
632292007793	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
632292007794	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
632292007795	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
632292007796	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
632292007797	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
632292007798	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
632292007799	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
632292007800	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
632292007801	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
632292007802	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
632292007803	NodB motif; other site
632292007804	putative active site [active]
632292007805	putative catalytic site [active]
632292007806	Zn binding site [ion binding]; other site
632292007807	regulatory protein SpoVG; Reviewed; Region: PRK13259
632292007808	pur operon repressor; Provisional; Region: PRK09213
632292007809	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
632292007810	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632292007811	active site
632292007812	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632292007813	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632292007814	metal binding site [ion binding]; metal-binding site
632292007815	active site
632292007816	I-site; other site
632292007817	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
632292007818	Transposase; Region: DEDD_Tnp_IS110; pfam01548
632292007819	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
632292007820	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
632292007821	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632292007822	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292007823	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
632292007824	Walker A/P-loop; other site
632292007825	ATP binding site [chemical binding]; other site
632292007826	Q-loop/lid; other site
632292007827	ABC transporter signature motif; other site
632292007828	Walker B; other site
632292007829	D-loop; other site
632292007830	H-loop/switch region; other site
632292007831	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632292007832	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632292007833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632292007834	Walker A/P-loop; other site
632292007835	ATP binding site [chemical binding]; other site
632292007836	Q-loop/lid; other site
632292007837	ABC transporter signature motif; other site
632292007838	Walker B; other site
632292007839	D-loop; other site
632292007840	H-loop/switch region; other site
632292007841	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
632292007842	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292007843	putative Zn2+ binding site [ion binding]; other site
632292007844	putative DNA binding site [nucleotide binding]; other site
632292007845	Protein of unknown function (DUF554); Region: DUF554; pfam04474
632292007846	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632292007847	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632292007848	Walker A/P-loop; other site
632292007849	ATP binding site [chemical binding]; other site
632292007850	Q-loop/lid; other site
632292007851	ABC transporter signature motif; other site
632292007852	Walker B; other site
632292007853	D-loop; other site
632292007854	H-loop/switch region; other site
632292007855	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
632292007856	ABC-2 type transporter; Region: ABC2_membrane; cl17235
632292007857	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
632292007858	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
632292007859	Histidine kinase; Region: HisKA_3; pfam07730
632292007860	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
632292007861	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
632292007862	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292007863	active site
632292007864	phosphorylation site [posttranslational modification]
632292007865	intermolecular recognition site; other site
632292007866	dimerization interface [polypeptide binding]; other site
632292007867	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
632292007868	DNA binding residues [nucleotide binding]
632292007869	dimerization interface [polypeptide binding]; other site
632292007870	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632292007871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292007872	active site
632292007873	phosphorylation site [posttranslational modification]
632292007874	intermolecular recognition site; other site
632292007875	dimerization interface [polypeptide binding]; other site
632292007876	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632292007877	DNA binding site [nucleotide binding]
632292007878	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632292007879	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
632292007880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632292007881	ATP binding site [chemical binding]; other site
632292007882	Mg2+ binding site [ion binding]; other site
632292007883	G-X-G motif; other site
632292007884	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632292007885	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
632292007886	Walker A/P-loop; other site
632292007887	ATP binding site [chemical binding]; other site
632292007888	Q-loop/lid; other site
632292007889	ABC transporter signature motif; other site
632292007890	Walker B; other site
632292007891	D-loop; other site
632292007892	H-loop/switch region; other site
632292007893	Response regulator receiver domain; Region: Response_reg; pfam00072
632292007894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632292007895	phosphorylation site [posttranslational modification]
632292007896	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
632292007897	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
632292007898	dimerization interface [polypeptide binding]; other site
632292007899	DNA binding residues [nucleotide binding]
632292007900	protease3; Provisional; Region: PRK15101
632292007901	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
632292007902	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632292007903	dimerization interface [polypeptide binding]; other site
632292007904	putative DNA binding site [nucleotide binding]; other site
632292007905	putative Zn2+ binding site [ion binding]; other site
632292007906	Predicted permeases [General function prediction only]; Region: COG0701
632292007907	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
632292007908	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
632292007909	Helix-turn-helix domain; Region: HTH_18; pfam12833
632292007910	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632292007911	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
632292007912	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632292007913	putative active site [active]
632292007914	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
632292007915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292007916	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632292007917	putative substrate translocation pore; other site
632292007918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632292007919	putative substrate translocation pore; other site
632292007920	biotin synthase; Provisional; Region: PRK07094
632292007921	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632292007922	FeS/SAM binding site; other site
632292007923	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
632292007924	Transglycosylase; Region: Transgly; pfam00912
632292007925	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
632292007926	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
632292007927	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
632292007928	Transposase domain (DUF772); Region: DUF772; pfam05598
632292007929	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
632292007930	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
632292007931	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
632292007932	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
632292007933	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
632292007934	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
632292007935	DEAD-like helicases superfamily; Region: DEXDc; smart00487
632292007936	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
632292007937	CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592
632292007938	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
632292007939	Family of unknown function (DUF694); Region: DUF694; pfam05107
632292007940	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730
632292007941	hypothetical protein; Provisional; Region: PRK09956
632292007942	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632292007943	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
632292007944	Archaeal ATPase; Region: Arch_ATPase; pfam01637
632292007945	AAA domain; Region: AAA_14; pfam13173
632292007946	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
632292007947	Domain of unknown function DUF87; Region: DUF87; pfam01935
632292007948	AAA-like domain; Region: AAA_10; pfam12846
632292007949	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
632292007950	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
632292007951	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
632292007952	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
632292007953	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
632292007954	Protein of unknown function (DUF310); Region: DUF310; pfam03750
632292007955	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
632292007956	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
632292007957	Archaeal ATPase; Region: Arch_ATPase; pfam01637
632292007958	AAA ATPase domain; Region: AAA_16; pfam13191
632292007959	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
632292007960	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
632292007961	Restriction endonuclease; Region: Mrr_cat; pfam04471
632292007962	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
632292007963	CRISPR-associated protein, MJ1666 family; Region: cas_MJ1666; TIGR01897
632292007964	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
632292007965	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
632292007966	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
632292007967	active site
632292007968	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
632292007969	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
632292007970	V-type ATP synthase subunit I; Validated; Region: PRK05771
632292007971	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
632292007972	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
632292007973	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
632292007974	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
632292007975	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
632292007976	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
632292007977	BioY family; Region: BioY; pfam02632
632292007978	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
632292007979	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
632292007980	DNA binding site [nucleotide binding]
632292007981	AAA domain; Region: AAA_30; pfam13604
632292007982	Family description; Region: UvrD_C_2; pfam13538
632292007983	YvrJ protein family; Region: YvrJ; pfam12841
632292007984	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
632292007985	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
632292007986	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
632292007987	stage V sporulation protein AD; Validated; Region: PRK08304
632292007988	stage V sporulation protein AD; Provisional; Region: PRK12404
632292007989	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
632292007990	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
632292007991	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
632292007992	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
632292007993	substrate binding pocket [chemical binding]; other site
632292007994	membrane-bound complex binding site; other site
632292007995	hinge residues; other site
632292007996	PAS domain S-box; Region: sensory_box; TIGR00229
632292007997	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
632292007998	putative active site [active]
632292007999	heme pocket [chemical binding]; other site
632292008000	PAS fold; Region: PAS_3; pfam08447
632292008001	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
632292008002	heme pocket [chemical binding]; other site
632292008003	putative active site [active]
632292008004	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632292008005	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632292008006	metal binding site [ion binding]; metal-binding site
632292008007	active site
632292008008	I-site; other site
632292008009	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
632292008010	WYL domain; Region: WYL; pfam13280
632292008011	WYL domain; Region: WYL; pfam13280
632292008012	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
632292008013	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632292008014	dimerization interface [polypeptide binding]; other site
632292008015	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632292008016	dimer interface [polypeptide binding]; other site
632292008017	putative CheW interface [polypeptide binding]; other site
632292008018	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
632292008019	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
632292008020	fumarate hydratase; Provisional; Region: PRK06246
632292008021	Colicin V production protein; Region: Colicin_V; pfam02674
632292008022	PAS fold; Region: PAS_4; pfam08448
632292008023	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
632292008024	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
632292008025	ParB-like nuclease domain; Region: ParB; smart00470
632292008026	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
632292008027	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
632292008028	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
632292008029	P-loop; other site
632292008030	Magnesium ion binding site [ion binding]; other site
632292008031	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
632292008032	Magnesium ion binding site [ion binding]; other site
632292008033	hypothetical protein; Provisional; Region: PRK09956
632292008034	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632292008035	Bacterial Ig-like domain; Region: Big_5; pfam13205
632292008036	PBP superfamily domain; Region: PBP_like_2; cl17296
632292008037	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
632292008038	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
632292008039	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
632292008040	dimer interface [polypeptide binding]; other site
632292008041	active site
632292008042	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
632292008043	ParB-like nuclease domain; Region: ParB; smart00470
632292008044	KorB domain; Region: KorB; pfam08535
632292008045	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
632292008046	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
632292008047	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
632292008048	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
632292008049	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
632292008050	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
632292008051	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
632292008052	trmE is a tRNA modification GTPase; Region: trmE; cd04164
632292008053	G1 box; other site
632292008054	GTP/Mg2+ binding site [chemical binding]; other site
632292008055	Switch I region; other site
632292008056	G2 box; other site
632292008057	Switch II region; other site
632292008058	G3 box; other site
632292008059	G4 box; other site
632292008060	G5 box; other site
632292008061	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
632292008062	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
632292008063	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
632292008064	G-X-X-G motif; other site
632292008065	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
632292008066	RxxxH motif; other site
632292008067	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
632292008068	Haemolytic domain; Region: Haemolytic; pfam01809
632292008069	Ribonuclease P; Region: Ribonuclease_P; cl00457
632292008070	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
632292008071	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
632292008072	Spore germination protein; Region: Spore_permease; cl17796
632292008073	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
632292008074	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504