-- dump date 20140619_020334 -- class Genbank::misc_feature -- table misc_feature_note -- id note 632335000001 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 632335000002 Int/Topo IB signature motif; other site 632335000003 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 632335000004 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 632335000005 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632335000006 endonuclease III; Region: ENDO3c; smart00478 632335000007 minor groove reading motif; other site 632335000008 helix-hairpin-helix signature motif; other site 632335000009 substrate binding pocket [chemical binding]; other site 632335000010 active site 632335000011 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 632335000012 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 632335000013 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 632335000014 cofactor binding site; other site 632335000015 DNA binding site [nucleotide binding] 632335000016 substrate interaction site [chemical binding]; other site 632335000017 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 632335000018 Helix-turn-helix domain; Region: HTH_17; pfam12728 632335000019 Helix-turn-helix domain; Region: HTH_36; pfam13730 632335000020 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 632335000021 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632335000022 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 632335000023 bacterial Hfq-like; Region: Hfq; cd01716 632335000024 hexamer interface [polypeptide binding]; other site 632335000025 Sm1 motif; other site 632335000026 RNA binding site [nucleotide binding]; other site 632335000027 Sm2 motif; other site 632335000028 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 632335000029 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 632335000030 DnaA N-terminal domain; Region: DnaA_N; pfam11638 632335000031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335000032 Walker A motif; other site 632335000033 ATP binding site [chemical binding]; other site 632335000034 Walker B motif; other site 632335000035 arginine finger; other site 632335000036 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 632335000037 DnaA box-binding interface [nucleotide binding]; other site 632335000038 DNA polymerase III subunit beta; Validated; Region: PRK05643 632335000039 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 632335000040 putative DNA binding surface [nucleotide binding]; other site 632335000041 dimer interface [polypeptide binding]; other site 632335000042 beta-clamp/clamp loader binding surface; other site 632335000043 beta-clamp/translesion DNA polymerase binding surface; other site 632335000044 recombination protein F; Reviewed; Region: recF; PRK00064 632335000045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335000046 Walker A/P-loop; other site 632335000047 ATP binding site [chemical binding]; other site 632335000048 Q-loop/lid; other site 632335000049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335000050 ABC transporter signature motif; other site 632335000051 Walker B; other site 632335000052 D-loop; other site 632335000053 H-loop/switch region; other site 632335000054 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 632335000055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335000056 ATP binding site [chemical binding]; other site 632335000057 Mg2+ binding site [ion binding]; other site 632335000058 G-X-G motif; other site 632335000059 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 632335000060 anchoring element; other site 632335000061 dimer interface [polypeptide binding]; other site 632335000062 ATP binding site [chemical binding]; other site 632335000063 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 632335000064 active site 632335000065 putative metal-binding site [ion binding]; other site 632335000066 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 632335000067 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 632335000068 DNA gyrase subunit A; Validated; Region: PRK05560 632335000069 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 632335000070 CAP-like domain; other site 632335000071 active site 632335000072 primary dimer interface [polypeptide binding]; other site 632335000073 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632335000074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632335000075 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632335000076 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632335000077 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632335000078 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632335000079 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 632335000080 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 632335000081 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335000082 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 632335000083 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335000084 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632335000085 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632335000086 FtsX-like permease family; Region: FtsX; pfam02687 632335000087 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632335000088 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632335000089 Walker A/P-loop; other site 632335000090 ATP binding site [chemical binding]; other site 632335000091 Q-loop/lid; other site 632335000092 ABC transporter signature motif; other site 632335000093 Walker B; other site 632335000094 D-loop; other site 632335000095 H-loop/switch region; other site 632335000096 Cellulose binding domain; Region: CBM_3; pfam00942 632335000097 Cellulose binding domain; Region: CBM_3; cl03026 632335000098 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 632335000099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632335000100 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632335000101 Integrase core domain; Region: rve; pfam00665 632335000102 Beta propeller domain; Region: Beta_propel; pfam09826 632335000103 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632335000104 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000105 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000106 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000107 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000108 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632335000109 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000110 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000111 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632335000112 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000113 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632335000114 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632335000115 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000116 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000117 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632335000118 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000119 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000120 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632335000121 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632335000122 S-layer homology domain; Region: SLH; pfam00395 632335000123 S-layer homology domain; Region: SLH; pfam00395 632335000124 S-layer homology domain; Region: SLH; pfam00395 632335000125 Transposase, Mutator family; Region: Transposase_mut; pfam00872 632335000126 MULE transposase domain; Region: MULE; pfam10551 632335000127 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335000128 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335000129 Integrase core domain; Region: rve; pfam00665 632335000130 Transposase domain (DUF772); Region: DUF772; pfam05598 632335000131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632335000132 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 632335000133 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632335000134 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 632335000135 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632335000136 Catalytic site [active] 632335000137 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 632335000138 PIN domain; Region: PIN_3; pfam13470 632335000139 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 632335000140 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 632335000141 DNA binding residues [nucleotide binding] 632335000142 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 632335000143 catalytic residues [active] 632335000144 catalytic nucleophile [active] 632335000145 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632335000146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335000147 active site 632335000148 phosphorylation site [posttranslational modification] 632335000149 intermolecular recognition site; other site 632335000150 dimerization interface [polypeptide binding]; other site 632335000151 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632335000152 DNA binding residues [nucleotide binding] 632335000153 dimerization interface [polypeptide binding]; other site 632335000154 Histidine kinase; Region: HisKA_3; pfam07730 632335000155 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 632335000156 ATP binding site [chemical binding]; other site 632335000157 Mg2+ binding site [ion binding]; other site 632335000158 G-X-G motif; other site 632335000159 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 632335000160 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 632335000161 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632335000162 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632335000163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335000164 Walker A/P-loop; other site 632335000165 ATP binding site [chemical binding]; other site 632335000166 Q-loop/lid; other site 632335000167 ABC transporter signature motif; other site 632335000168 Walker B; other site 632335000169 D-loop; other site 632335000170 H-loop/switch region; other site 632335000171 YycH protein; Region: YycI; cl02015 632335000172 Protein of unknown function (DUF554); Region: DUF554; pfam04474 632335000173 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632335000174 MarR family; Region: MarR; pfam01047 632335000175 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632335000176 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335000177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335000178 Walker A/P-loop; other site 632335000179 ATP binding site [chemical binding]; other site 632335000180 Q-loop/lid; other site 632335000181 ABC transporter signature motif; other site 632335000182 Walker B; other site 632335000183 D-loop; other site 632335000184 H-loop/switch region; other site 632335000185 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632335000186 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335000187 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 632335000188 Walker A/P-loop; other site 632335000189 ATP binding site [chemical binding]; other site 632335000190 Q-loop/lid; other site 632335000191 ABC transporter signature motif; other site 632335000192 Walker B; other site 632335000193 D-loop; other site 632335000194 H-loop/switch region; other site 632335000195 Yip1 domain; Region: Yip1; pfam04893 632335000196 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 632335000197 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335000198 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632335000199 carboxyltransferase (CT) interaction site; other site 632335000200 biotinylation site [posttranslational modification]; other site 632335000201 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335000202 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632335000203 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632335000204 FtsX-like permease family; Region: FtsX; pfam02687 632335000205 SurA N-terminal domain; Region: SurA_N_3; cl07813 632335000206 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 632335000207 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 632335000208 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 632335000209 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 632335000210 Walker A/P-loop; other site 632335000211 ATP binding site [chemical binding]; other site 632335000212 Q-loop/lid; other site 632335000213 ABC transporter signature motif; other site 632335000214 Walker B; other site 632335000215 D-loop; other site 632335000216 H-loop/switch region; other site 632335000217 Protein of unknown function (DUF970); Region: DUF970; cl17525 632335000218 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 632335000219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632335000220 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 632335000221 Iron permease FTR1 family; Region: FTR1; cl00475 632335000222 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 632335000223 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 632335000224 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 632335000225 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 632335000226 Ligand Binding Site [chemical binding]; other site 632335000227 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 632335000228 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 632335000229 Int/Topo IB signature motif; other site 632335000230 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632335000231 putative active site [active] 632335000232 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632335000233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632335000234 non-specific DNA binding site [nucleotide binding]; other site 632335000235 salt bridge; other site 632335000236 sequence-specific DNA binding site [nucleotide binding]; other site 632335000237 Helix-turn-helix domain; Region: HTH_17; pfam12728 632335000238 CHC2 zinc finger; Region: zf-CHC2; cl17510 632335000239 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 632335000240 active site 632335000241 metal binding site [ion binding]; metal-binding site 632335000242 interdomain interaction site; other site 632335000243 Domain of unknown function (DUF927); Region: DUF927; pfam06048 632335000244 sporulation sigma factor SigK; Reviewed; Region: PRK05803 632335000245 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335000246 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 632335000247 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632335000248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632335000249 non-specific DNA binding site [nucleotide binding]; other site 632335000250 salt bridge; other site 632335000251 sequence-specific DNA binding site [nucleotide binding]; other site 632335000252 Domain of unknown function (DUF955); Region: DUF955; pfam06114 632335000253 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632335000254 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632335000255 active site 632335000256 DNA binding site [nucleotide binding] 632335000257 Int/Topo IB signature motif; other site 632335000258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632335000259 sequence-specific DNA binding site [nucleotide binding]; other site 632335000260 salt bridge; other site 632335000261 DNA binding domain, excisionase family; Region: excise; TIGR01764 632335000262 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 632335000263 AAA domain; Region: AAA_25; pfam13481 632335000264 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 632335000265 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632335000266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335000267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 632335000268 MULE transposase domain; Region: MULE; pfam10551 632335000269 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 632335000270 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632335000271 dimer interface [polypeptide binding]; other site 632335000272 active site 632335000273 metal binding site [ion binding]; metal-binding site 632335000274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335000275 S-adenosylmethionine binding site [chemical binding]; other site 632335000276 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 632335000277 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 632335000278 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 632335000279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335000280 S-adenosylmethionine binding site [chemical binding]; other site 632335000281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632335000282 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 632335000283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632335000284 Coenzyme A binding pocket [chemical binding]; other site 632335000285 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632335000286 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 632335000287 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632335000288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335000289 active site 632335000290 phosphorylation site [posttranslational modification] 632335000291 intermolecular recognition site; other site 632335000292 dimerization interface [polypeptide binding]; other site 632335000293 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632335000294 DNA binding site [nucleotide binding] 632335000295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632335000296 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632335000297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632335000298 dimer interface [polypeptide binding]; other site 632335000299 phosphorylation site [posttranslational modification] 632335000300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335000301 ATP binding site [chemical binding]; other site 632335000302 Mg2+ binding site [ion binding]; other site 632335000303 G-X-G motif; other site 632335000304 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632335000305 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632335000306 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 632335000307 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 632335000308 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 632335000309 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 632335000310 B12 binding site [chemical binding]; other site 632335000311 cobalt ligand [ion binding]; other site 632335000312 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 632335000313 intersubunit interface [polypeptide binding]; other site 632335000314 active site 632335000315 Zn2+ binding site [ion binding]; other site 632335000316 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 632335000317 homodimer interface [polypeptide binding]; other site 632335000318 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 632335000319 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 632335000320 active site 632335000321 homodimer interface [polypeptide binding]; other site 632335000322 catalytic site [active] 632335000323 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632335000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335000325 putative PBP binding loops; other site 632335000326 ABC-ATPase subunit interface; other site 632335000327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335000328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335000329 dimer interface [polypeptide binding]; other site 632335000330 conserved gate region; other site 632335000331 putative PBP binding loops; other site 632335000332 ABC-ATPase subunit interface; other site 632335000333 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632335000334 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 632335000335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632335000336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632335000337 DNA binding site [nucleotide binding] 632335000338 domain linker motif; other site 632335000339 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 632335000340 putative dimerization interface [polypeptide binding]; other site 632335000341 putative ligand binding site [chemical binding]; other site 632335000342 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 632335000343 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335000344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632335000345 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632335000346 Integrase core domain; Region: rve; pfam00665 632335000347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 632335000348 MULE transposase domain; Region: MULE; pfam10551 632335000349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 632335000350 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 632335000351 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 632335000352 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 632335000353 homodimer interface [polypeptide binding]; other site 632335000354 active site 632335000355 catalytic site [active] 632335000356 maltose binding site 2 [chemical binding]; other site 632335000357 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 632335000358 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 632335000359 putative active site [active] 632335000360 putative metal binding site [ion binding]; other site 632335000361 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 632335000362 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 632335000363 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632335000364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632335000365 DNA-binding site [nucleotide binding]; DNA binding site 632335000366 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632335000367 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 632335000368 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 632335000369 putative substrate binding site [chemical binding]; other site 632335000370 putative ATP binding site [chemical binding]; other site 632335000371 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 632335000372 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 632335000373 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632335000374 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 632335000375 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 632335000376 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632335000377 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632335000378 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 632335000379 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335000380 Walker A/P-loop; other site 632335000381 ATP binding site [chemical binding]; other site 632335000382 Q-loop/lid; other site 632335000383 ABC transporter signature motif; other site 632335000384 Walker B; other site 632335000385 D-loop; other site 632335000386 H-loop/switch region; other site 632335000387 CAAX protease self-immunity; Region: Abi; pfam02517 632335000388 Short C-terminal domain; Region: SHOCT; pfam09851 632335000389 Rubrerythrin [Energy production and conversion]; Region: COG1592 632335000390 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 632335000391 binuclear metal center [ion binding]; other site 632335000392 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 632335000393 iron binding site [ion binding]; other site 632335000394 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632335000395 metal binding site 2 [ion binding]; metal-binding site 632335000396 putative DNA binding helix; other site 632335000397 metal binding site 1 [ion binding]; metal-binding site 632335000398 dimer interface [polypeptide binding]; other site 632335000399 structural Zn2+ binding site [ion binding]; other site 632335000400 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 632335000401 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 632335000402 Ca binding site [ion binding]; other site 632335000403 active site 632335000404 catalytic site [active] 632335000405 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 632335000406 membrane protein; Provisional; Region: PRK14404 632335000407 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 632335000408 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 632335000409 active site 632335000410 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 632335000411 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 632335000412 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335000413 FeS/SAM binding site; other site 632335000414 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 632335000415 Response regulator receiver domain; Region: Response_reg; pfam00072 632335000416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335000417 active site 632335000418 phosphorylation site [posttranslational modification] 632335000419 intermolecular recognition site; other site 632335000420 dimerization interface [polypeptide binding]; other site 632335000421 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 632335000422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335000423 S-adenosylmethionine binding site [chemical binding]; other site 632335000424 Predicted methyltransferases [General function prediction only]; Region: COG0313 632335000425 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 632335000426 putative SAM binding site [chemical binding]; other site 632335000427 putative homodimer interface [polypeptide binding]; other site 632335000428 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 632335000429 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 632335000430 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335000431 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335000432 Integrase core domain; Region: rve; pfam00665 632335000433 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632335000434 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632335000435 DNA binding site [nucleotide binding] 632335000436 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632335000437 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632335000438 putative metal binding site [ion binding]; other site 632335000439 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632335000440 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335000441 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335000442 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632335000443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335000444 dimer interface [polypeptide binding]; other site 632335000445 conserved gate region; other site 632335000446 putative PBP binding loops; other site 632335000447 ABC-ATPase subunit interface; other site 632335000448 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335000449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335000450 dimer interface [polypeptide binding]; other site 632335000451 conserved gate region; other site 632335000452 putative PBP binding loops; other site 632335000453 ABC-ATPase subunit interface; other site 632335000454 NHL repeat; Region: NHL; pfam01436 632335000455 Uncharacterized conserved protein [Function unknown]; Region: COG3391 632335000456 NHL repeat; Region: NHL; pfam01436 632335000457 Tetratricopeptide repeat; Region: TPR_16; pfam13432 632335000458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632335000459 TPR motif; other site 632335000460 binding surface 632335000461 Yip1 domain; Region: Yip1; pfam04893 632335000462 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632335000463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632335000464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335000465 ABC-ATPase subunit interface; other site 632335000466 putative PBP binding loops; other site 632335000467 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335000468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335000469 dimer interface [polypeptide binding]; other site 632335000470 conserved gate region; other site 632335000471 putative PBP binding loops; other site 632335000472 ABC-ATPase subunit interface; other site 632335000473 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335000474 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335000475 Carbohydrate binding module 27; Region: CBM27; pfam09212 632335000476 Carbohydrate binding module 27; Region: CBM27; pfam09212 632335000477 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632335000478 putative metal binding site [ion binding]; other site 632335000479 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 632335000480 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632335000481 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632335000482 G5 domain; Region: G5; pfam07501 632335000483 Peptidase family M23; Region: Peptidase_M23; pfam01551 632335000484 Probable transposase; Region: OrfB_IS605; pfam01385 632335000485 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335000486 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632335000487 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 632335000488 Ligand Binding Site [chemical binding]; other site 632335000489 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 632335000490 homotrimer interaction site [polypeptide binding]; other site 632335000491 putative active site [active] 632335000492 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 632335000493 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 632335000494 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104 632335000495 charged pocket; other site 632335000496 hydrophobic patch; other site 632335000497 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 632335000498 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 632335000499 Ligand Binding Site [chemical binding]; other site 632335000500 TIGR00269 family protein; Region: TIGR00269 632335000501 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 632335000502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335000503 FeS/SAM binding site; other site 632335000504 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 632335000505 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 632335000506 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 632335000507 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 632335000508 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632335000509 nucleotide binding site [chemical binding]; other site 632335000510 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 632335000511 Rrf2 family protein; Region: rrf2_super; TIGR00738 632335000512 Transcriptional regulator; Region: Rrf2; pfam02082 632335000513 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632335000514 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 632335000515 ACS interaction site; other site 632335000516 CODH interaction site; other site 632335000517 metal cluster binding site [ion binding]; other site 632335000518 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 632335000519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632335000520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632335000521 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632335000522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632335000523 putative DNA binding site [nucleotide binding]; other site 632335000524 putative Zn2+ binding site [ion binding]; other site 632335000525 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632335000526 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335000527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335000528 Walker A/P-loop; other site 632335000529 ATP binding site [chemical binding]; other site 632335000530 Q-loop/lid; other site 632335000531 ABC transporter signature motif; other site 632335000532 Walker B; other site 632335000533 D-loop; other site 632335000534 H-loop/switch region; other site 632335000535 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632335000536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335000537 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 632335000538 Walker A/P-loop; other site 632335000539 ATP binding site [chemical binding]; other site 632335000540 Q-loop/lid; other site 632335000541 ABC transporter signature motif; other site 632335000542 Walker B; other site 632335000543 D-loop; other site 632335000544 H-loop/switch region; other site 632335000545 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 632335000546 trimer interface [polypeptide binding]; other site 632335000547 putative Zn binding site [ion binding]; other site 632335000548 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 632335000549 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632335000550 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632335000551 dimer interface [polypeptide binding]; other site 632335000552 putative CheW interface [polypeptide binding]; other site 632335000553 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632335000554 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632335000555 hinge; other site 632335000556 active site 632335000557 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 632335000558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632335000559 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 632335000560 dimerization interface [polypeptide binding]; other site 632335000561 putative DNA binding site [nucleotide binding]; other site 632335000562 putative Zn2+ binding site [ion binding]; other site 632335000563 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 632335000564 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 632335000565 dihydropteroate synthase; Region: DHPS; TIGR01496 632335000566 substrate binding pocket [chemical binding]; other site 632335000567 dimer interface [polypeptide binding]; other site 632335000568 inhibitor binding site; inhibition site 632335000569 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 632335000570 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 632335000571 catalytic center binding site [active] 632335000572 ATP binding site [chemical binding]; other site 632335000573 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 632335000574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632335000575 NAD(P) binding site [chemical binding]; other site 632335000576 active site 632335000577 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632335000578 putative active site [active] 632335000579 phage shock protein A; Region: phageshock_pspA; TIGR02977 632335000580 stage II sporulation protein E; Region: spore_II_E; TIGR02865 632335000581 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 632335000582 stage II sporulation protein D; Region: spore_II_D; TIGR02870 632335000583 Stage II sporulation protein; Region: SpoIID; pfam08486 632335000584 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 632335000585 SurA N-terminal domain; Region: SurA_N_3; cl07813 632335000586 NAD synthetase; Provisional; Region: PRK13981 632335000587 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 632335000588 multimer interface [polypeptide binding]; other site 632335000589 active site 632335000590 catalytic triad [active] 632335000591 protein interface 1 [polypeptide binding]; other site 632335000592 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 632335000593 homodimer interface [polypeptide binding]; other site 632335000594 NAD binding pocket [chemical binding]; other site 632335000595 ATP binding pocket [chemical binding]; other site 632335000596 Mg binding site [ion binding]; other site 632335000597 active-site loop [active] 632335000598 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 632335000599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 632335000600 Transposase; Region: DDE_Tnp_ISL3; pfam01610 632335000601 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632335000602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632335000603 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632335000604 dimerization interface [polypeptide binding]; other site 632335000605 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632335000606 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 632335000607 active site 632335000608 FMN binding site [chemical binding]; other site 632335000609 substrate binding site [chemical binding]; other site 632335000610 putative catalytic residue [active] 632335000611 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 632335000612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632335000613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632335000614 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632335000615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335000616 active site 632335000617 phosphorylation site [posttranslational modification] 632335000618 intermolecular recognition site; other site 632335000619 dimerization interface [polypeptide binding]; other site 632335000620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335000621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335000622 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 632335000623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335000624 dimerization interface [polypeptide binding]; other site 632335000625 Histidine kinase; Region: His_kinase; pfam06580 632335000626 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 632335000627 ATP binding site [chemical binding]; other site 632335000628 Mg2+ binding site [ion binding]; other site 632335000629 G-X-G motif; other site 632335000630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335000631 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335000632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335000633 dimer interface [polypeptide binding]; other site 632335000634 conserved gate region; other site 632335000635 putative PBP binding loops; other site 632335000636 ABC-ATPase subunit interface; other site 632335000637 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335000638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335000639 dimer interface [polypeptide binding]; other site 632335000640 conserved gate region; other site 632335000641 putative PBP binding loops; other site 632335000642 ABC-ATPase subunit interface; other site 632335000643 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 632335000644 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 632335000645 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 632335000646 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 632335000647 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 632335000648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335000649 FeS/SAM binding site; other site 632335000650 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 632335000651 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 632335000652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335000653 FeS/SAM binding site; other site 632335000654 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 632335000655 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 632335000656 C-terminal peptidase (prc); Region: prc; TIGR00225 632335000657 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 632335000658 Active site serine [active] 632335000659 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 632335000660 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335000661 Walker A/P-loop; other site 632335000662 ATP binding site [chemical binding]; other site 632335000663 Q-loop/lid; other site 632335000664 ABC transporter signature motif; other site 632335000665 Walker B; other site 632335000666 D-loop; other site 632335000667 H-loop/switch region; other site 632335000668 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 632335000669 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 632335000670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335000671 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632335000672 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 632335000673 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 632335000674 active site 632335000675 Substrate binding site; other site 632335000676 Mg++ binding site; other site 632335000677 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632335000678 putative trimer interface [polypeptide binding]; other site 632335000679 putative CoA binding site [chemical binding]; other site 632335000680 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 632335000681 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 632335000682 active site 632335000683 metal binding site [ion binding]; metal-binding site 632335000684 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 632335000685 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 632335000686 Predicted integral membrane protein [Function unknown]; Region: COG5652 632335000687 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 632335000688 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 632335000689 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 632335000690 TrkA-N domain; Region: TrkA_N; pfam02254 632335000691 TrkA-C domain; Region: TrkA_C; pfam02080 632335000692 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 632335000693 TrkA-N domain; Region: TrkA_N; pfam02254 632335000694 Stage II sporulation protein; Region: SpoIID; pfam08486 632335000695 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 632335000696 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 632335000697 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 632335000698 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 632335000699 TIGR02677 family protein; Region: TIGR02677 632335000700 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 632335000701 TIGR02680 family protein; Region: TIGR02680 632335000702 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 632335000703 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 632335000704 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 632335000705 active site 632335000706 metal binding site [ion binding]; metal-binding site 632335000707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335000708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632335000709 dimerization interface [polypeptide binding]; other site 632335000710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632335000711 dimer interface [polypeptide binding]; other site 632335000712 phosphorylation site [posttranslational modification] 632335000713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335000714 ATP binding site [chemical binding]; other site 632335000715 Mg2+ binding site [ion binding]; other site 632335000716 G-X-G motif; other site 632335000717 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632335000718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335000719 active site 632335000720 phosphorylation site [posttranslational modification] 632335000721 intermolecular recognition site; other site 632335000722 dimerization interface [polypeptide binding]; other site 632335000723 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632335000724 DNA binding site [nucleotide binding] 632335000725 4Fe-4S binding domain; Region: Fer4_5; pfam12801 632335000726 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 632335000727 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632335000728 Transposase IS200 like; Region: Y1_Tnp; pfam01797 632335000729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632335000730 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632335000731 Probable transposase; Region: OrfB_IS605; pfam01385 632335000732 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335000733 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 632335000734 iron binding site [ion binding]; other site 632335000735 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 632335000736 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632335000737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335000738 active site 632335000739 phosphorylation site [posttranslational modification] 632335000740 intermolecular recognition site; other site 632335000741 dimerization interface [polypeptide binding]; other site 632335000742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632335000743 DNA binding site [nucleotide binding] 632335000744 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 632335000745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335000746 dimerization interface [polypeptide binding]; other site 632335000747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632335000748 dimer interface [polypeptide binding]; other site 632335000749 phosphorylation site [posttranslational modification] 632335000750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335000751 ATP binding site [chemical binding]; other site 632335000752 Mg2+ binding site [ion binding]; other site 632335000753 G-X-G motif; other site 632335000754 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632335000755 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 632335000756 putative metal binding site [ion binding]; other site 632335000757 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 632335000758 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632335000759 ABC-ATPase subunit interface; other site 632335000760 dimer interface [polypeptide binding]; other site 632335000761 putative PBP binding regions; other site 632335000762 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632335000763 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632335000764 Walker A/P-loop; other site 632335000765 ATP binding site [chemical binding]; other site 632335000766 Q-loop/lid; other site 632335000767 ABC transporter signature motif; other site 632335000768 Walker B; other site 632335000769 D-loop; other site 632335000770 H-loop/switch region; other site 632335000771 Transposase IS200 like; Region: Y1_Tnp; pfam01797 632335000772 Probable transposase; Region: OrfB_IS605; pfam01385 632335000773 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335000774 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632335000775 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 632335000776 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 632335000777 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 632335000778 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 632335000779 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 632335000780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335000781 active site 632335000782 phosphorylation site [posttranslational modification] 632335000783 intermolecular recognition site; other site 632335000784 dimerization interface [polypeptide binding]; other site 632335000785 CheB methylesterase; Region: CheB_methylest; pfam01339 632335000786 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 632335000787 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 632335000788 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 632335000789 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 632335000790 active site 632335000791 HIGH motif; other site 632335000792 KMSKS motif; other site 632335000793 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 632335000794 tRNA binding surface [nucleotide binding]; other site 632335000795 anticodon binding site; other site 632335000796 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 632335000797 dimer interface [polypeptide binding]; other site 632335000798 putative tRNA-binding site [nucleotide binding]; other site 632335000799 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 632335000800 active site 632335000801 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 632335000802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335000803 FeS/SAM binding site; other site 632335000804 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 632335000805 Bifunctional nuclease; Region: DNase-RNase; pfam02577 632335000806 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632335000807 Heavy-metal-associated domain; Region: HMA; pfam00403 632335000808 metal-binding site [ion binding] 632335000809 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632335000810 Soluble P-type ATPase [General function prediction only]; Region: COG4087 632335000811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632335000812 dimerization interface [polypeptide binding]; other site 632335000813 putative DNA binding site [nucleotide binding]; other site 632335000814 putative Zn2+ binding site [ion binding]; other site 632335000815 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632335000816 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335000817 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 632335000818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335000819 active site 632335000820 motif I; other site 632335000821 motif II; other site 632335000822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335000823 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 632335000824 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 632335000825 FAD binding domain; Region: FAD_binding_4; pfam01565 632335000826 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 632335000827 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 632335000828 AAA domain; Region: AAA_18; pfam13238 632335000829 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 632335000830 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 632335000831 phosphate binding site [ion binding]; other site 632335000832 putative substrate binding pocket [chemical binding]; other site 632335000833 dimer interface [polypeptide binding]; other site 632335000834 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 632335000835 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 632335000836 Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048 632335000837 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 632335000838 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 632335000839 regulatory protein interface [polypeptide binding]; other site 632335000840 active site 632335000841 regulatory phosphorylation site [posttranslational modification]; other site 632335000842 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 632335000843 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 632335000844 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 632335000845 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 632335000846 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 632335000847 FAD binding site [chemical binding]; other site 632335000848 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 632335000849 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 632335000850 putative active site [active] 632335000851 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335000852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335000853 Walker A/P-loop; other site 632335000854 ATP binding site [chemical binding]; other site 632335000855 Q-loop/lid; other site 632335000856 ABC transporter signature motif; other site 632335000857 Walker B; other site 632335000858 D-loop; other site 632335000859 H-loop/switch region; other site 632335000860 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 632335000861 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 632335000862 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335000863 CAAX protease self-immunity; Region: Abi; pfam02517 632335000864 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 632335000865 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632335000866 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335000867 Walker A/P-loop; other site 632335000868 ATP binding site [chemical binding]; other site 632335000869 Q-loop/lid; other site 632335000870 ABC transporter signature motif; other site 632335000871 Walker B; other site 632335000872 D-loop; other site 632335000873 H-loop/switch region; other site 632335000874 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 632335000875 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 632335000876 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 632335000877 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 632335000878 Part of AAA domain; Region: AAA_19; pfam13245 632335000879 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632335000880 Family description; Region: UvrD_C_2; pfam13538 632335000881 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 632335000882 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 632335000883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335000884 FeS/SAM binding site; other site 632335000885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335000886 putative substrate translocation pore; other site 632335000887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632335000888 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632335000889 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632335000890 DNA binding site [nucleotide binding] 632335000891 domain linker motif; other site 632335000892 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 632335000893 dimerization interface [polypeptide binding]; other site 632335000894 ligand binding site [chemical binding]; other site 632335000895 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632335000896 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632335000897 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632335000898 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632335000899 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632335000900 AP (apurinic/apyrimidinic) site pocket; other site 632335000901 DNA interaction; other site 632335000902 Metal-binding active site; metal-binding site 632335000903 hypothetical protein; Provisional; Region: PRK03881 632335000904 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 632335000905 AMMECR1; Region: AMMECR1; pfam01871 632335000906 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 632335000907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335000908 FeS/SAM binding site; other site 632335000909 Uncharacterized conserved protein [Function unknown]; Region: COG1624 632335000910 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 632335000911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 632335000912 YbbR-like protein; Region: YbbR; pfam07949 632335000913 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 632335000914 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 632335000915 GIY-YIG motif/motif A; other site 632335000916 active site 632335000917 catalytic site [active] 632335000918 putative DNA binding site [nucleotide binding]; other site 632335000919 metal binding site [ion binding]; metal-binding site 632335000920 UvrB/uvrC motif; Region: UVR; pfam02151 632335000921 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 632335000922 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 632335000923 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 632335000924 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 632335000925 Hpr binding site; other site 632335000926 active site 632335000927 homohexamer subunit interaction site [polypeptide binding]; other site 632335000928 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 632335000929 thiS-thiF/thiG interaction site; other site 632335000930 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 632335000931 ThiS interaction site; other site 632335000932 putative active site [active] 632335000933 tetramer interface [polypeptide binding]; other site 632335000934 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 632335000935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335000936 FeS/SAM binding site; other site 632335000937 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 632335000938 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 632335000939 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 632335000940 ATP binding site [chemical binding]; other site 632335000941 substrate interface [chemical binding]; other site 632335000942 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 632335000943 thiamine phosphate binding site [chemical binding]; other site 632335000944 active site 632335000945 pyrophosphate binding site [ion binding]; other site 632335000946 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 632335000947 ThiC family; Region: ThiC; pfam01964 632335000948 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 632335000949 dimer interface [polypeptide binding]; other site 632335000950 substrate binding site [chemical binding]; other site 632335000951 ATP binding site [chemical binding]; other site 632335000952 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 632335000953 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 632335000954 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 632335000955 Transposase domain (DUF772); Region: DUF772; pfam05598 632335000956 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632335000957 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 632335000958 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 632335000959 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 632335000960 Ligand binding site; other site 632335000961 Putative Catalytic site; other site 632335000962 DXD motif; other site 632335000963 Predicted membrane protein [Function unknown]; Region: COG2246 632335000964 GtrA-like protein; Region: GtrA; pfam04138 632335000965 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 632335000966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335000967 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632335000968 FeS/SAM binding site; other site 632335000969 Preprotein translocase subunit; Region: YajC; pfam02699 632335000970 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 632335000971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335000972 S-adenosylmethionine binding site [chemical binding]; other site 632335000973 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 632335000974 active site 632335000975 substrate-binding site [chemical binding]; other site 632335000976 metal-binding site [ion binding] 632335000977 GTP binding site [chemical binding]; other site 632335000978 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 632335000979 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 632335000980 Substrate binding site; other site 632335000981 Cupin domain; Region: Cupin_2; cl17218 632335000982 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 632335000983 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 632335000984 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 632335000985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335000986 motif II; other site 632335000987 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 632335000988 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 632335000989 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632335000990 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 632335000991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335000992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335000993 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632335000994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335000995 putative PBP binding loops; other site 632335000996 dimer interface [polypeptide binding]; other site 632335000997 ABC-ATPase subunit interface; other site 632335000998 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335000999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335001000 dimer interface [polypeptide binding]; other site 632335001001 conserved gate region; other site 632335001002 putative PBP binding loops; other site 632335001003 ABC-ATPase subunit interface; other site 632335001004 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632335001005 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632335001006 DNA binding site [nucleotide binding] 632335001007 domain linker motif; other site 632335001008 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632335001009 ligand binding site [chemical binding]; other site 632335001010 dimerization interface [polypeptide binding]; other site 632335001011 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 632335001012 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 632335001013 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632335001014 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 632335001015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632335001016 Probable transposase; Region: OrfB_IS605; pfam01385 632335001017 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335001018 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632335001019 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632335001020 active site 632335001021 catalytic tetrad [active] 632335001022 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 632335001023 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 632335001024 glutamine binding [chemical binding]; other site 632335001025 catalytic triad [active] 632335001026 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 632335001027 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 632335001028 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 632335001029 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 632335001030 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 632335001031 homodimer interface [polypeptide binding]; other site 632335001032 substrate-cofactor binding pocket; other site 632335001033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335001034 catalytic residue [active] 632335001035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632335001036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632335001037 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632335001038 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632335001039 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 632335001040 Predicted permeases [General function prediction only]; Region: COG0730 632335001041 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 632335001042 active site 1 [active] 632335001043 active site 2 [active] 632335001044 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 632335001045 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 632335001046 Potassium binding sites [ion binding]; other site 632335001047 Cesium cation binding sites [ion binding]; other site 632335001048 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 632335001049 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 632335001050 substrate-cofactor binding pocket; other site 632335001051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335001052 catalytic residue [active] 632335001053 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632335001054 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632335001055 NAD(P) binding site [chemical binding]; other site 632335001056 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632335001057 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632335001058 DNA binding site [nucleotide binding] 632335001059 domain linker motif; other site 632335001060 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 632335001061 putative dimerization interface [polypeptide binding]; other site 632335001062 putative ligand binding site [chemical binding]; other site 632335001063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632335001064 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632335001065 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 632335001066 Predicted methyltransferases [General function prediction only]; Region: COG1568 632335001067 Uncharacterized conserved protein [Function unknown]; Region: COG0585 632335001068 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 632335001069 active site 632335001070 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 632335001071 putative acetyltransferase; Provisional; Region: PRK03624 632335001072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632335001073 Coenzyme A binding pocket [chemical binding]; other site 632335001074 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 632335001075 putative active site [active] 632335001076 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 632335001077 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632335001078 active site 632335001079 NTP binding site [chemical binding]; other site 632335001080 metal binding triad [ion binding]; metal-binding site 632335001081 antibiotic binding site [chemical binding]; other site 632335001082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632335001083 Probable transposase; Region: OrfB_IS605; pfam01385 632335001084 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335001085 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 632335001086 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 632335001087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335001088 Walker A motif; other site 632335001089 ATP binding site [chemical binding]; other site 632335001090 Walker B motif; other site 632335001091 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 632335001092 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 632335001093 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632335001094 ABC-ATPase subunit interface; other site 632335001095 dimer interface [polypeptide binding]; other site 632335001096 putative PBP binding regions; other site 632335001097 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 632335001098 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 632335001099 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632335001100 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 632335001101 intersubunit interface [polypeptide binding]; other site 632335001102 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632335001103 metal binding site 2 [ion binding]; metal-binding site 632335001104 putative DNA binding helix; other site 632335001105 metal binding site 1 [ion binding]; metal-binding site 632335001106 dimer interface [polypeptide binding]; other site 632335001107 structural Zn2+ binding site [ion binding]; other site 632335001108 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632335001109 dimerization interface [polypeptide binding]; other site 632335001110 putative DNA binding site [nucleotide binding]; other site 632335001111 putative Zn2+ binding site [ion binding]; other site 632335001112 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335001113 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632335001114 FeS/SAM binding site; other site 632335001115 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 632335001116 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 632335001117 hypothetical protein; Reviewed; Region: PRK09588 632335001118 DNA protecting protein DprA; Region: dprA; TIGR00732 632335001119 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 632335001120 DNA topoisomerase I; Validated; Region: PRK05582 632335001121 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 632335001122 active site 632335001123 interdomain interaction site; other site 632335001124 putative metal-binding site [ion binding]; other site 632335001125 nucleotide binding site [chemical binding]; other site 632335001126 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 632335001127 domain I; other site 632335001128 DNA binding groove [nucleotide binding] 632335001129 phosphate binding site [ion binding]; other site 632335001130 domain II; other site 632335001131 domain III; other site 632335001132 nucleotide binding site [chemical binding]; other site 632335001133 catalytic site [active] 632335001134 domain IV; other site 632335001135 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 632335001136 RNA polymerase subunit 9; Region: RPOL9; smart00661 632335001137 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 632335001138 Glucose inhibited division protein A; Region: GIDA; pfam01134 632335001139 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 632335001140 active site 632335001141 HslU subunit interaction site [polypeptide binding]; other site 632335001142 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 632335001143 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 632335001144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335001145 Walker A motif; other site 632335001146 ATP binding site [chemical binding]; other site 632335001147 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 632335001148 Walker B motif; other site 632335001149 arginine finger; other site 632335001150 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 632335001151 transcriptional repressor CodY; Validated; Region: PRK04158 632335001152 CodY GAF-like domain; Region: CodY; pfam06018 632335001153 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 632335001154 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 632335001155 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 632335001156 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 632335001157 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 632335001158 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 632335001159 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 632335001160 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 632335001161 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 632335001162 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 632335001163 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 632335001164 FliG C-terminal domain; Region: FliG_C; pfam01706 632335001165 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 632335001166 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 632335001167 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 632335001168 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 632335001169 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 632335001170 Walker A motif/ATP binding site; other site 632335001171 Walker B motif; other site 632335001172 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 632335001173 Uncharacterized conserved protein [Function unknown]; Region: COG3334 632335001174 MgtE intracellular N domain; Region: MgtE_N; cl15244 632335001175 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 632335001176 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 632335001177 FlgD Tudor-like domain; Region: FLgD_tudor; cl17881 632335001178 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 632335001179 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 632335001180 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 632335001181 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 632335001182 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 632335001183 Flagellar protein (FlbD); Region: FlbD; pfam06289 632335001184 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 632335001185 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 632335001186 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 632335001187 flagellar motor switch protein; Validated; Region: PRK08119 632335001188 CheC-like family; Region: CheC; pfam04509 632335001189 CheC-like family; Region: CheC; pfam04509 632335001190 Sporulation related domain; Region: SPOR; cl10051 632335001191 flagellar motor switch protein FliN; Region: fliN; TIGR02480 632335001192 Response regulator receiver domain; Region: Response_reg; pfam00072 632335001193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335001194 active site 632335001195 phosphorylation site [posttranslational modification] 632335001196 intermolecular recognition site; other site 632335001197 dimerization interface [polypeptide binding]; other site 632335001198 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 632335001199 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 632335001200 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 632335001201 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 632335001202 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 632335001203 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 632335001204 FHIPEP family; Region: FHIPEP; pfam00771 632335001205 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 632335001206 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632335001207 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 632335001208 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 632335001209 P-loop; other site 632335001210 Flagellar protein YcgR; Region: YcgR_2; pfam12945 632335001211 PilZ domain; Region: PilZ; pfam07238 632335001212 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 632335001213 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 632335001214 putative binding surface; other site 632335001215 active site 632335001216 P2 response regulator binding domain; Region: P2; pfam07194 632335001217 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 632335001218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335001219 ATP binding site [chemical binding]; other site 632335001220 Mg2+ binding site [ion binding]; other site 632335001221 G-X-G motif; other site 632335001222 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 632335001223 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632335001224 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 632335001225 CheC-like family; Region: CheC; pfam04509 632335001226 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 632335001227 CheC-like family; Region: CheC; pfam04509 632335001228 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 632335001229 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 632335001230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335001231 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632335001232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335001233 DNA binding residues [nucleotide binding] 632335001234 Protein of unknown function (DUF342); Region: DUF342; pfam03961 632335001235 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335001236 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335001237 Integrase core domain; Region: rve; pfam00665 632335001238 Cupin domain; Region: Cupin_2; pfam07883 632335001239 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 632335001240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335001241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335001242 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 632335001243 oligomerisation interface [polypeptide binding]; other site 632335001244 mobile loop; other site 632335001245 roof hairpin; other site 632335001246 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 632335001247 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 632335001248 ring oligomerisation interface [polypeptide binding]; other site 632335001249 ATP/Mg binding site [chemical binding]; other site 632335001250 stacking interactions; other site 632335001251 hinge regions; other site 632335001252 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632335001253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335001254 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 632335001255 active site 632335001256 motif I; other site 632335001257 motif II; other site 632335001258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335001259 Uncharacterized conserved protein [Function unknown]; Region: COG2006 632335001260 Domain of unknown function (DUF362); Region: DUF362; pfam04015 632335001261 4Fe-4S binding domain; Region: Fer4_6; pfam12837 632335001262 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632335001263 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 632335001264 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 632335001265 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 632335001266 EDD domain protein, DegV family; Region: DegV; TIGR00762 632335001267 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 632335001268 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 632335001269 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 632335001270 B12 binding site [chemical binding]; other site 632335001271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335001272 FeS/SAM binding site; other site 632335001273 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 632335001274 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 632335001275 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 632335001276 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 632335001277 homodimer interface [polypeptide binding]; other site 632335001278 oligonucleotide binding site [chemical binding]; other site 632335001279 elongation factor P; Validated; Region: PRK00529 632335001280 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 632335001281 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 632335001282 RNA binding site [nucleotide binding]; other site 632335001283 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 632335001284 RNA binding site [nucleotide binding]; other site 632335001285 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 632335001286 homodimer interface [polypeptide binding]; other site 632335001287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335001288 catalytic residue [active] 632335001289 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 632335001290 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 632335001291 ligand binding site [chemical binding]; other site 632335001292 NAD binding site [chemical binding]; other site 632335001293 dimerization interface [polypeptide binding]; other site 632335001294 catalytic site [active] 632335001295 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 632335001296 putative L-serine binding site [chemical binding]; other site 632335001297 Uncharacterized conserved protein [Function unknown]; Region: COG4198 632335001298 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 632335001299 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 632335001300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335001301 motif II; other site 632335001302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335001303 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 632335001304 Fic family protein [Function unknown]; Region: COG3177 632335001305 Fic/DOC family; Region: Fic; pfam02661 632335001306 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632335001307 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 632335001308 putative substrate binding site [chemical binding]; other site 632335001309 putative ATP binding site [chemical binding]; other site 632335001310 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 632335001311 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 632335001312 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 632335001313 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 632335001314 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 632335001315 Penicillinase repressor; Region: Pencillinase_R; cl17580 632335001316 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 632335001317 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335001318 Zn2+ binding site [ion binding]; other site 632335001319 Mg2+ binding site [ion binding]; other site 632335001320 ribonuclease R; Region: RNase_R; TIGR02063 632335001321 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 632335001322 RNA binding site [nucleotide binding]; other site 632335001323 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 632335001324 RNB domain; Region: RNB; pfam00773 632335001325 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 632335001326 RNA binding site [nucleotide binding]; other site 632335001327 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 632335001328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335001329 Walker A motif; other site 632335001330 ATP binding site [chemical binding]; other site 632335001331 Walker B motif; other site 632335001332 arginine finger; other site 632335001333 Uncharacterized conserved protein [Function unknown]; Region: COG2006 632335001334 Domain of unknown function (DUF362); Region: DUF362; pfam04015 632335001335 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 632335001336 30S subunit binding site; other site 632335001337 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 632335001338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335001339 ATP binding site [chemical binding]; other site 632335001340 putative Mg++ binding site [ion binding]; other site 632335001341 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 632335001342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335001343 nucleotide binding region [chemical binding]; other site 632335001344 ATP-binding site [chemical binding]; other site 632335001345 peptide chain release factor 2; Validated; Region: prfB; PRK00578 632335001346 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 632335001347 linker region; other site 632335001348 This domain is found in peptide chain release factors; Region: PCRF; smart00937 632335001349 RF-1 domain; Region: RF-1; pfam00472 632335001350 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 632335001351 Response regulator receiver domain; Region: Response_reg; pfam00072 632335001352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335001353 active site 632335001354 phosphorylation site [posttranslational modification] 632335001355 intermolecular recognition site; other site 632335001356 dimerization interface [polypeptide binding]; other site 632335001357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632335001358 dimer interface [polypeptide binding]; other site 632335001359 phosphorylation site [posttranslational modification] 632335001360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335001361 ATP binding site [chemical binding]; other site 632335001362 Mg2+ binding site [ion binding]; other site 632335001363 G-X-G motif; other site 632335001364 Response regulator receiver domain; Region: Response_reg; pfam00072 632335001365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335001366 active site 632335001367 phosphorylation site [posttranslational modification] 632335001368 intermolecular recognition site; other site 632335001369 dimerization interface [polypeptide binding]; other site 632335001370 HDOD domain; Region: HDOD; pfam08668 632335001371 Response regulator receiver domain; Region: Response_reg; pfam00072 632335001372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335001373 active site 632335001374 phosphorylation site [posttranslational modification] 632335001375 intermolecular recognition site; other site 632335001376 dimerization interface [polypeptide binding]; other site 632335001377 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 632335001378 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 632335001379 substrate binding site [chemical binding]; other site 632335001380 ligand binding site [chemical binding]; other site 632335001381 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 632335001382 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 632335001383 substrate binding site [chemical binding]; other site 632335001384 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 632335001385 tartrate dehydrogenase; Region: TTC; TIGR02089 632335001386 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 632335001387 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632335001388 active site 632335001389 catalytic tetrad [active] 632335001390 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632335001391 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 632335001392 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 632335001393 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632335001394 dimer interface [polypeptide binding]; other site 632335001395 ssDNA binding site [nucleotide binding]; other site 632335001396 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632335001397 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 632335001398 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 632335001399 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 632335001400 23S rRNA interface [nucleotide binding]; other site 632335001401 L3 interface [polypeptide binding]; other site 632335001402 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 632335001403 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632335001404 Winged helix-turn helix; Region: HTH_29; pfam13551 632335001405 Integrase core domain; Region: rve; pfam00665 632335001406 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 632335001407 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 632335001408 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632335001409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335001410 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632335001411 DNA repair protein RadA; Provisional; Region: PRK11823 632335001412 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 632335001413 Walker A motif/ATP binding site; other site 632335001414 ATP binding site [chemical binding]; other site 632335001415 Walker B motif; other site 632335001416 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 632335001417 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 632335001418 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 632335001419 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 632335001420 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 632335001421 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 632335001422 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 632335001423 Uncharacterized conserved protein [Function unknown]; Region: COG1284 632335001424 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 632335001425 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 632335001426 transketolase; Reviewed; Region: PRK05899 632335001427 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 632335001428 TPP-binding site [chemical binding]; other site 632335001429 dimer interface [polypeptide binding]; other site 632335001430 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 632335001431 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 632335001432 PYR/PP interface [polypeptide binding]; other site 632335001433 dimer interface [polypeptide binding]; other site 632335001434 TPP binding site [chemical binding]; other site 632335001435 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632335001436 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 632335001437 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632335001438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335001439 putative alpha-glucosidase; Provisional; Region: PRK10658 632335001440 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 632335001441 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 632335001442 active site 632335001443 homotrimer interface [polypeptide binding]; other site 632335001444 catalytic site [active] 632335001445 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 632335001446 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 632335001447 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335001448 dimerization interface [polypeptide binding]; other site 632335001449 Histidine kinase; Region: His_kinase; pfam06580 632335001450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335001451 ATP binding site [chemical binding]; other site 632335001452 Mg2+ binding site [ion binding]; other site 632335001453 G-X-G motif; other site 632335001454 Response regulator receiver domain; Region: Response_reg; pfam00072 632335001455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335001456 active site 632335001457 phosphorylation site [posttranslational modification] 632335001458 intermolecular recognition site; other site 632335001459 dimerization interface [polypeptide binding]; other site 632335001460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335001461 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632335001462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335001463 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632335001464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335001465 dimer interface [polypeptide binding]; other site 632335001466 conserved gate region; other site 632335001467 ABC-ATPase subunit interface; other site 632335001468 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335001469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335001470 dimer interface [polypeptide binding]; other site 632335001471 conserved gate region; other site 632335001472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632335001473 ABC-ATPase subunit interface; other site 632335001474 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335001475 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335001476 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335001477 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 632335001478 MgtC family; Region: MgtC; pfam02308 632335001479 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 632335001480 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 632335001481 homodimer interface [polypeptide binding]; other site 632335001482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335001483 catalytic residue [active] 632335001484 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 632335001485 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 632335001486 dimerization interface [polypeptide binding]; other site 632335001487 active site 632335001488 metal binding site [ion binding]; metal-binding site 632335001489 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 632335001490 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 632335001491 DNA replication protein DnaC; Validated; Region: PRK06835 632335001492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335001493 Walker A motif; other site 632335001494 ATP binding site [chemical binding]; other site 632335001495 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 632335001496 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 632335001497 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 632335001498 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632335001499 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 632335001500 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 632335001501 YacP-like NYN domain; Region: NYN_YacP; pfam05991 632335001502 RNA polymerase factor sigma-70; Validated; Region: PRK08295 632335001503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335001504 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632335001505 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 632335001506 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 632335001507 active site 632335001508 substrate binding site [chemical binding]; other site 632335001509 metal binding site [ion binding]; metal-binding site 632335001510 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 632335001511 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 632335001512 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 632335001513 glutamate racemase; Provisional; Region: PRK00865 632335001514 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 632335001515 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 632335001516 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 632335001517 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 632335001518 active site 632335001519 HIGH motif; other site 632335001520 KMSK motif region; other site 632335001521 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 632335001522 tRNA binding surface [nucleotide binding]; other site 632335001523 anticodon binding site; other site 632335001524 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632335001525 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 632335001526 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 632335001527 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632335001528 active site 632335001529 FMN binding site [chemical binding]; other site 632335001530 substrate binding site [chemical binding]; other site 632335001531 3Fe-4S cluster binding site [ion binding]; other site 632335001532 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 632335001533 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 632335001534 NAD binding site [chemical binding]; other site 632335001535 sugar binding site [chemical binding]; other site 632335001536 divalent metal binding site [ion binding]; other site 632335001537 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 632335001538 dimer interface [polypeptide binding]; other site 632335001539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632335001540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632335001541 metal binding site [ion binding]; metal-binding site 632335001542 active site 632335001543 I-site; other site 632335001544 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 632335001545 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 632335001546 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 632335001547 active site 632335001548 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 632335001549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632335001550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632335001551 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632335001552 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632335001553 active site residue [active] 632335001554 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 632335001555 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 632335001556 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 632335001557 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632335001558 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632335001559 G5 domain; Region: G5; pfam07501 632335001560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 632335001561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 632335001562 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 632335001563 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632335001564 Domain of unknown function (DUF377); Region: DUF377; pfam04041 632335001565 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 632335001566 active site 632335001567 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632335001568 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 632335001569 putative NAD(P) binding site [chemical binding]; other site 632335001570 catalytic Zn binding site [ion binding]; other site 632335001571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335001572 ATP binding site [chemical binding]; other site 632335001573 Mg2+ binding site [ion binding]; other site 632335001574 G-X-G motif; other site 632335001575 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 632335001576 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 632335001577 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 632335001578 substrate binding site [chemical binding]; other site 632335001579 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 632335001580 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 632335001581 Ecdysteroid kinase; Region: EcKinase; cl17738 632335001582 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 632335001583 substrate binding site [chemical binding]; other site 632335001584 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632335001585 nucleotide binding site [chemical binding]; other site 632335001586 Type III pantothenate kinase; Region: Pan_kinase; cl17198 632335001587 hypothetical protein; Provisional; Region: PRK02877 632335001588 aspartate aminotransferase; Provisional; Region: PRK06290 632335001589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632335001590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335001591 homodimer interface [polypeptide binding]; other site 632335001592 catalytic residue [active] 632335001593 4Fe-4S binding domain; Region: Fer4_5; pfam12801 632335001594 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632335001595 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 632335001596 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 632335001597 ATP cone domain; Region: ATP-cone; pfam03477 632335001598 Class III ribonucleotide reductase; Region: RNR_III; cd01675 632335001599 effector binding site; other site 632335001600 active site 632335001601 Zn binding site [ion binding]; other site 632335001602 glycine loop; other site 632335001603 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335001604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335001605 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335001606 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 632335001607 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 632335001608 nucleoside/Zn binding site; other site 632335001609 dimer interface [polypeptide binding]; other site 632335001610 catalytic motif [active] 632335001611 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 632335001612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632335001613 ATP binding site [chemical binding]; other site 632335001614 Mg2+ binding site [ion binding]; other site 632335001615 G-X-G motif; other site 632335001616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 632335001617 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 632335001618 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632335001619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 632335001620 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 632335001621 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632335001622 minor groove reading motif; other site 632335001623 helix-hairpin-helix signature motif; other site 632335001624 substrate binding pocket [chemical binding]; other site 632335001625 active site 632335001626 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335001627 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335001628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335001629 dimer interface [polypeptide binding]; other site 632335001630 conserved gate region; other site 632335001631 putative PBP binding loops; other site 632335001632 ABC-ATPase subunit interface; other site 632335001633 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335001634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335001635 dimer interface [polypeptide binding]; other site 632335001636 conserved gate region; other site 632335001637 putative PBP binding loops; other site 632335001638 ABC-ATPase subunit interface; other site 632335001639 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 632335001640 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632335001641 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632335001642 nucleotide binding site [chemical binding]; other site 632335001643 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632335001644 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632335001645 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 632335001646 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 632335001647 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 632335001648 dimer interface [polypeptide binding]; other site 632335001649 active site 632335001650 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 632335001651 dimer interface [polypeptide binding]; other site 632335001652 active site 632335001653 putative hydrolase; Validated; Region: PRK09248 632335001654 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 632335001655 active site 632335001656 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 632335001657 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 632335001658 intersubunit interface [polypeptide binding]; other site 632335001659 active site 632335001660 zinc binding site [ion binding]; other site 632335001661 Na+ binding site [ion binding]; other site 632335001662 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 632335001663 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 632335001664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335001665 FeS/SAM binding site; other site 632335001666 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 632335001667 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 632335001668 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 632335001669 trimer interface [polypeptide binding]; other site 632335001670 putative metal binding site [ion binding]; other site 632335001671 protein-export membrane protein SecD; Region: secD; TIGR01129 632335001672 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 632335001673 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 632335001674 Protein export membrane protein; Region: SecD_SecF; pfam02355 632335001675 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 632335001676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632335001677 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632335001678 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 632335001679 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 632335001680 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 632335001681 DNA binding residues [nucleotide binding] 632335001682 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 632335001683 catalytic residues [active] 632335001684 catalytic nucleophile [active] 632335001685 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632335001686 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335001687 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632335001688 Predicted amidohydrolase [General function prediction only]; Region: COG0388 632335001689 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 632335001690 active site 632335001691 catalytic triad [active] 632335001692 dimer interface [polypeptide binding]; other site 632335001693 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632335001694 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632335001695 hinge; other site 632335001696 active site 632335001697 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 632335001698 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 632335001699 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632335001700 active site 632335001701 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 632335001702 catalytic motif [active] 632335001703 Zn binding site [ion binding]; other site 632335001704 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 632335001705 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 632335001706 Substrate binding site; other site 632335001707 Mg++ binding site; other site 632335001708 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 632335001709 active site 632335001710 substrate binding site [chemical binding]; other site 632335001711 CoA binding site [chemical binding]; other site 632335001712 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 632335001713 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 632335001714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632335001715 active site 632335001716 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 632335001717 putative active site [active] 632335001718 catalytic residue [active] 632335001719 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 632335001720 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 632335001721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335001722 ATP binding site [chemical binding]; other site 632335001723 putative Mg++ binding site [ion binding]; other site 632335001724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335001725 nucleotide binding region [chemical binding]; other site 632335001726 ATP-binding site [chemical binding]; other site 632335001727 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 632335001728 SurA N-terminal domain; Region: SurA_N_3; cl07813 632335001729 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 632335001730 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 632335001731 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 632335001732 Ligand Binding Site [chemical binding]; other site 632335001733 TilS substrate C-terminal domain; Region: TilS_C; smart00977 632335001734 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632335001735 active site 632335001736 FtsH Extracellular; Region: FtsH_ext; pfam06480 632335001737 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 632335001738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335001739 Walker A motif; other site 632335001740 ATP binding site [chemical binding]; other site 632335001741 Walker B motif; other site 632335001742 arginine finger; other site 632335001743 Peptidase family M41; Region: Peptidase_M41; pfam01434 632335001744 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 632335001745 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 632335001746 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 632335001747 putative oxidoreductase; Provisional; Region: PRK12831 632335001748 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632335001749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632335001750 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 632335001751 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 632335001752 FAD binding pocket [chemical binding]; other site 632335001753 FAD binding motif [chemical binding]; other site 632335001754 phosphate binding motif [ion binding]; other site 632335001755 beta-alpha-beta structure motif; other site 632335001756 NAD binding pocket [chemical binding]; other site 632335001757 Iron coordination center [ion binding]; other site 632335001758 Stage III sporulation protein D; Region: SpoIIID; pfam12116 632335001759 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 632335001760 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 632335001761 homodimer interface [polypeptide binding]; other site 632335001762 metal binding site [ion binding]; metal-binding site 632335001763 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 632335001764 homodimer interface [polypeptide binding]; other site 632335001765 active site 632335001766 putative chemical substrate binding site [chemical binding]; other site 632335001767 metal binding site [ion binding]; metal-binding site 632335001768 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 632335001769 IHF dimer interface [polypeptide binding]; other site 632335001770 IHF - DNA interface [nucleotide binding]; other site 632335001771 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632335001772 RNA binding surface [nucleotide binding]; other site 632335001773 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 632335001774 YabP family; Region: YabP; cl06766 632335001775 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 632335001776 Septum formation initiator; Region: DivIC; cl17659 632335001777 hypothetical protein; Provisional; Region: PRK08582 632335001778 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 632335001779 RNA binding site [nucleotide binding]; other site 632335001780 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 632335001781 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 632335001782 CoA binding domain; Region: CoA_binding; smart00881 632335001783 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 632335001784 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 632335001785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335001786 catalytic residue [active] 632335001787 MgtE intracellular N domain; Region: MgtE_N; pfam03448 632335001788 FOG: CBS domain [General function prediction only]; Region: COG0517 632335001789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 632335001790 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 632335001791 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 632335001792 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 632335001793 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 632335001794 PDGLE domain; Region: PDGLE; pfam13190 632335001795 Cobalt transport protein; Region: CbiQ; cl00463 632335001796 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632335001797 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632335001798 Walker A/P-loop; other site 632335001799 ATP binding site [chemical binding]; other site 632335001800 Q-loop/lid; other site 632335001801 ABC transporter signature motif; other site 632335001802 Walker B; other site 632335001803 D-loop; other site 632335001804 H-loop/switch region; other site 632335001805 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 632335001806 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 632335001807 active site 632335001808 AAA ATPase domain; Region: AAA_16; pfam13191 632335001809 DNA methylase; Region: N6_N4_Mtase; cl17433 632335001810 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 632335001811 DNA methylase; Region: N6_N4_Mtase; cl17433 632335001812 PglZ domain; Region: PglZ; pfam08665 632335001813 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 632335001814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335001815 Zn2+ binding site [ion binding]; other site 632335001816 Mg2+ binding site [ion binding]; other site 632335001817 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 632335001818 Divergent AAA domain; Region: AAA_4; pfam04326 632335001819 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 632335001820 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 632335001821 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 632335001822 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 632335001823 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 632335001824 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632335001825 active site 632335001826 NTP binding site [chemical binding]; other site 632335001827 metal binding triad [ion binding]; metal-binding site 632335001828 antibiotic binding site [chemical binding]; other site 632335001829 Protein of unknown function DUF86; Region: DUF86; cl01031 632335001830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 632335001831 MULE transposase domain; Region: MULE; pfam10551 632335001832 Protein of unknown function DUF45; Region: DUF45; pfam01863 632335001833 seryl-tRNA synthetase; Provisional; Region: PRK05431 632335001834 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 632335001835 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 632335001836 dimer interface [polypeptide binding]; other site 632335001837 active site 632335001838 motif 1; other site 632335001839 motif 2; other site 632335001840 motif 3; other site 632335001841 Uncharacterized conserved protein [Function unknown]; Region: COG0398 632335001842 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 632335001843 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 632335001844 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 632335001845 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 632335001846 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 632335001847 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 632335001848 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632335001849 dimer interface [polypeptide binding]; other site 632335001850 PYR/PP interface [polypeptide binding]; other site 632335001851 TPP binding site [chemical binding]; other site 632335001852 substrate binding site [chemical binding]; other site 632335001853 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 632335001854 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 632335001855 TPP-binding site [chemical binding]; other site 632335001856 putative dimer interface [polypeptide binding]; other site 632335001857 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 632335001858 Prephenate dehydratase; Region: PDT; pfam00800 632335001859 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 632335001860 putative L-Phe binding site [chemical binding]; other site 632335001861 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 632335001862 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 632335001863 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 632335001864 DHH family; Region: DHH; pfam01368 632335001865 DHHA1 domain; Region: DHHA1; pfam02272 632335001866 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 632335001867 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 632335001868 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 632335001869 replicative DNA helicase; Region: DnaB; TIGR00665 632335001870 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 632335001871 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 632335001872 Walker A motif; other site 632335001873 ATP binding site [chemical binding]; other site 632335001874 Walker B motif; other site 632335001875 DNA binding loops [nucleotide binding] 632335001876 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 632335001877 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 632335001878 homotetramer interface [polypeptide binding]; other site 632335001879 ligand binding site [chemical binding]; other site 632335001880 catalytic site [active] 632335001881 NAD binding site [chemical binding]; other site 632335001882 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 632335001883 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 632335001884 active site 632335001885 putative substrate binding pocket [chemical binding]; other site 632335001886 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 632335001887 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 632335001888 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 632335001889 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 632335001890 active site 632335001891 HIGH motif; other site 632335001892 dimer interface [polypeptide binding]; other site 632335001893 KMSKS motif; other site 632335001894 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632335001895 RNA binding surface [nucleotide binding]; other site 632335001896 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 632335001897 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632335001898 Putative amidase domain; Region: Amidase_6; pfam12671 632335001899 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632335001900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632335001901 non-specific DNA binding site [nucleotide binding]; other site 632335001902 salt bridge; other site 632335001903 sequence-specific DNA binding site [nucleotide binding]; other site 632335001904 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632335001905 putative active site [active] 632335001906 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632335001907 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 632335001908 Int/Topo IB signature motif; other site 632335001909 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 632335001910 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 632335001911 toxin interface [polypeptide binding]; other site 632335001912 Zn binding site [ion binding]; other site 632335001913 BRO family, N-terminal domain; Region: Bro-N; smart01040 632335001914 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 632335001915 PemK-like protein; Region: PemK; pfam02452 632335001916 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 632335001917 Protein of unknown function (DUF433); Region: DUF433; pfam04255 632335001918 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632335001919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 632335001920 MULE transposase domain; Region: MULE; pfam10551 632335001921 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 632335001922 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 632335001923 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 632335001924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335001925 ATP binding site [chemical binding]; other site 632335001926 putative Mg++ binding site [ion binding]; other site 632335001927 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 632335001928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335001929 nucleotide binding region [chemical binding]; other site 632335001930 ATP-binding site [chemical binding]; other site 632335001931 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 632335001932 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 632335001933 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 632335001934 Methyltransferase domain; Region: Methyltransf_26; pfam13659 632335001935 Methyltransferase domain; Region: Methyltransf_26; pfam13659 632335001936 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 632335001937 Protein of unknown function (DUF499); Region: DUF499; pfam04465 632335001938 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632335001939 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 632335001940 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 632335001941 putative active site [active] 632335001942 Helix-turn-helix domain; Region: HTH_17; pfam12728 632335001943 Helix-turn-helix domain; Region: HTH_17; pfam12728 632335001944 YARHG domain; Region: YARHG; pfam13308 632335001945 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 632335001946 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 632335001947 Ferritin-like domain; Region: Ferritin; pfam00210 632335001948 ferroxidase diiron center [ion binding]; other site 632335001949 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 632335001950 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 632335001951 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 632335001952 oligomerization interface [polypeptide binding]; other site 632335001953 active site 632335001954 metal binding site [ion binding]; metal-binding site 632335001955 pantoate--beta-alanine ligase; Region: panC; TIGR00018 632335001956 Pantoate-beta-alanine ligase; Region: PanC; cd00560 632335001957 active site 632335001958 ATP-binding site [chemical binding]; other site 632335001959 pantoate-binding site; other site 632335001960 HXXH motif; other site 632335001961 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 632335001962 tetramerization interface [polypeptide binding]; other site 632335001963 active site 632335001964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 632335001965 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 632335001966 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 632335001967 Coat F domain; Region: Coat_F; pfam07875 632335001968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 632335001969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632335001970 Coenzyme A binding pocket [chemical binding]; other site 632335001971 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335001972 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335001973 Integrase core domain; Region: rve; pfam00665 632335001974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632335001975 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632335001976 Integrase core domain; Region: rve; pfam00665 632335001977 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 632335001978 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 632335001979 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632335001980 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632335001981 DNA interaction; other site 632335001982 Metal-binding active site; metal-binding site 632335001983 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 632335001984 aspartate kinase; Reviewed; Region: PRK06635 632335001985 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 632335001986 putative catalytic residues [active] 632335001987 putative nucleotide binding site [chemical binding]; other site 632335001988 putative aspartate binding site [chemical binding]; other site 632335001989 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 632335001990 putative allosteric regulatory site; other site 632335001991 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 632335001992 putative allosteric regulatory residue; other site 632335001993 homoserine kinase; Provisional; Region: PRK01212 632335001994 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632335001995 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632335001996 homoserine dehydrogenase; Provisional; Region: PRK06349 632335001997 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 632335001998 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 632335001999 hypothetical protein; Provisional; Region: PRK04435 632335002000 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 632335002001 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 632335002002 Spore germination protein; Region: Spore_permease; cl17796 632335002003 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 632335002004 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 632335002005 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 632335002006 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632335002007 active site 632335002008 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 632335002009 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335002010 Zn2+ binding site [ion binding]; other site 632335002011 Mg2+ binding site [ion binding]; other site 632335002012 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 632335002013 synthetase active site [active] 632335002014 NTP binding site [chemical binding]; other site 632335002015 metal binding site [ion binding]; metal-binding site 632335002016 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 632335002017 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 632335002018 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 632335002019 putative active site [active] 632335002020 dimerization interface [polypeptide binding]; other site 632335002021 putative tRNAtyr binding site [nucleotide binding]; other site 632335002022 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632335002023 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 632335002024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335002025 FeS/SAM binding site; other site 632335002026 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 632335002027 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 632335002028 active site 632335002029 homodimer interface [polypeptide binding]; other site 632335002030 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632335002031 Interdomain contacts; other site 632335002032 Cytokine receptor motif; other site 632335002033 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632335002034 Interdomain contacts; other site 632335002035 Cytokine receptor motif; other site 632335002036 S-layer homology domain; Region: SLH; pfam00395 632335002037 S-layer homology domain; Region: SLH; pfam00395 632335002038 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632335002039 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632335002040 substrate binding pocket [chemical binding]; other site 632335002041 membrane-bound complex binding site; other site 632335002042 hinge residues; other site 632335002043 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 632335002044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335002045 dimer interface [polypeptide binding]; other site 632335002046 conserved gate region; other site 632335002047 putative PBP binding loops; other site 632335002048 ABC-ATPase subunit interface; other site 632335002049 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632335002050 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 632335002051 Walker A/P-loop; other site 632335002052 ATP binding site [chemical binding]; other site 632335002053 Q-loop/lid; other site 632335002054 ABC transporter signature motif; other site 632335002055 Walker B; other site 632335002056 D-loop; other site 632335002057 H-loop/switch region; other site 632335002058 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 632335002059 EamA-like transporter family; Region: EamA; pfam00892 632335002060 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 632335002061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 632335002062 Beta-Casp domain; Region: Beta-Casp; smart01027 632335002063 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632335002064 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632335002065 putative active site [active] 632335002066 trigger factor; Provisional; Region: tig; PRK01490 632335002067 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 632335002068 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 632335002069 Clp protease; Region: CLP_protease; pfam00574 632335002070 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 632335002071 oligomer interface [polypeptide binding]; other site 632335002072 active site residues [active] 632335002073 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 632335002074 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 632335002075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335002076 Walker A motif; other site 632335002077 ATP binding site [chemical binding]; other site 632335002078 Walker B motif; other site 632335002079 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 632335002080 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 632335002081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335002082 Zn2+ binding site [ion binding]; other site 632335002083 Mg2+ binding site [ion binding]; other site 632335002084 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 632335002085 DNA primase; Validated; Region: dnaG; PRK05667 632335002086 CHC2 zinc finger; Region: zf-CHC2; pfam01807 632335002087 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 632335002088 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 632335002089 active site 632335002090 metal binding site [ion binding]; metal-binding site 632335002091 interdomain interaction site; other site 632335002092 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 632335002093 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 632335002094 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 632335002095 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 632335002096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335002097 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632335002098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335002099 DNA binding residues [nucleotide binding] 632335002100 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 632335002101 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 632335002102 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 632335002103 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 632335002104 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 632335002105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335002106 FeS/SAM binding site; other site 632335002107 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 632335002108 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 632335002109 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 632335002110 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632335002111 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 632335002112 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 632335002113 active site 632335002114 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 632335002115 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 632335002116 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 632335002117 Competence protein; Region: Competence; pfam03772 632335002118 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 632335002119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632335002120 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 632335002121 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 632335002122 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 632335002123 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 632335002124 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 632335002125 NAD binding site [chemical binding]; other site 632335002126 dimer interface [polypeptide binding]; other site 632335002127 substrate binding site [chemical binding]; other site 632335002128 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632335002129 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632335002130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335002131 dimer interface [polypeptide binding]; other site 632335002132 conserved gate region; other site 632335002133 putative PBP binding loops; other site 632335002134 ABC-ATPase subunit interface; other site 632335002135 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 632335002136 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 632335002137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335002138 dimer interface [polypeptide binding]; other site 632335002139 conserved gate region; other site 632335002140 putative PBP binding loops; other site 632335002141 ABC-ATPase subunit interface; other site 632335002142 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 632335002143 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632335002144 Walker A/P-loop; other site 632335002145 ATP binding site [chemical binding]; other site 632335002146 Q-loop/lid; other site 632335002147 ABC transporter signature motif; other site 632335002148 Walker B; other site 632335002149 D-loop; other site 632335002150 H-loop/switch region; other site 632335002151 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 632335002152 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 632335002153 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632335002154 Walker A/P-loop; other site 632335002155 ATP binding site [chemical binding]; other site 632335002156 Q-loop/lid; other site 632335002157 ABC transporter signature motif; other site 632335002158 Walker B; other site 632335002159 D-loop; other site 632335002160 H-loop/switch region; other site 632335002161 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 632335002162 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 632335002163 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 632335002164 peptide binding site [polypeptide binding]; other site 632335002165 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632335002166 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 632335002167 metal binding site [ion binding]; metal-binding site 632335002168 dimer interface [polypeptide binding]; other site 632335002169 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 632335002170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632335002171 DNA-binding site [nucleotide binding]; DNA binding site 632335002172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632335002173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335002174 homodimer interface [polypeptide binding]; other site 632335002175 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 632335002176 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 632335002177 active site 632335002178 multimer interface [polypeptide binding]; other site 632335002179 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 632335002180 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 632335002181 predicted active site [active] 632335002182 catalytic triad [active] 632335002183 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 632335002184 Uncharacterized conserved protein [Function unknown]; Region: COG0062 632335002185 putative carbohydrate kinase; Provisional; Region: PRK10565 632335002186 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 632335002187 putative substrate binding site [chemical binding]; other site 632335002188 putative ATP binding site [chemical binding]; other site 632335002189 alanine racemase; Reviewed; Region: alr; PRK00053 632335002190 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 632335002191 active site 632335002192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632335002193 dimer interface [polypeptide binding]; other site 632335002194 substrate binding site [chemical binding]; other site 632335002195 catalytic residues [active] 632335002196 PemK-like protein; Region: PemK; pfam02452 632335002197 Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087 632335002198 Rho binding site 1 [polypeptide binding]; other site 632335002199 putative Rho binding site 2 [polypeptide binding]; other site 632335002200 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 632335002201 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 632335002202 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 632335002203 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 632335002204 catalytic residues [active] 632335002205 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632335002206 lipoyl-biotinyl attachment site [posttranslational modification]; other site 632335002207 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632335002208 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632335002209 intersubunit interface [polypeptide binding]; other site 632335002210 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 632335002211 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632335002212 ABC-ATPase subunit interface; other site 632335002213 dimer interface [polypeptide binding]; other site 632335002214 putative PBP binding regions; other site 632335002215 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632335002216 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632335002217 Walker A/P-loop; other site 632335002218 ATP binding site [chemical binding]; other site 632335002219 Q-loop/lid; other site 632335002220 ABC transporter signature motif; other site 632335002221 Walker B; other site 632335002222 D-loop; other site 632335002223 H-loop/switch region; other site 632335002224 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 632335002225 Bacterial SH3 domain; Region: SH3_3; pfam08239 632335002226 Bacterial SH3 domain homologues; Region: SH3b; smart00287 632335002227 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632335002228 NlpC/P60 family; Region: NLPC_P60; pfam00877 632335002229 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 632335002230 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 632335002231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335002232 active site 632335002233 motif I; other site 632335002234 motif II; other site 632335002235 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 632335002236 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 632335002237 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 632335002238 shikimate binding site; other site 632335002239 NAD(P) binding site [chemical binding]; other site 632335002240 Response regulator receiver domain; Region: Response_reg; pfam00072 632335002241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335002242 active site 632335002243 phosphorylation site [posttranslational modification] 632335002244 intermolecular recognition site; other site 632335002245 dimerization interface [polypeptide binding]; other site 632335002246 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 632335002247 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 632335002248 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 632335002249 Walker A motif; other site 632335002250 ATP binding site [chemical binding]; other site 632335002251 Walker B motif; other site 632335002252 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 632335002253 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632335002254 Walker A motif; other site 632335002255 ATP binding site [chemical binding]; other site 632335002256 Walker B motif; other site 632335002257 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 632335002258 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 632335002259 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 632335002260 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 632335002261 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 632335002262 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 632335002263 Late competence development protein ComFB; Region: ComFB; pfam10719 632335002264 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 632335002265 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 632335002266 Double zinc ribbon; Region: DZR; pfam12773 632335002267 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 632335002268 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 632335002269 cyclase homology domain; Region: CHD; cd07302 632335002270 nucleotidyl binding site; other site 632335002271 metal binding site [ion binding]; metal-binding site 632335002272 dimer interface [polypeptide binding]; other site 632335002273 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632335002274 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 632335002275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632335002276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 632335002277 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632335002278 TPR motif; other site 632335002279 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632335002280 binding surface 632335002281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632335002282 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 632335002283 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 632335002284 S-layer homology domain; Region: SLH; pfam00395 632335002285 S-layer homology domain; Region: SLH; pfam00395 632335002286 S-layer homology domain; Region: SLH; pfam00395 632335002287 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 632335002288 Fe-S cluster binding site [ion binding]; other site 632335002289 active site 632335002290 acetylornithine aminotransferase; Provisional; Region: PRK02627 632335002291 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632335002292 inhibitor-cofactor binding pocket; inhibition site 632335002293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335002294 catalytic residue [active] 632335002295 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 632335002296 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 632335002297 Uncharacterized membrane protein [Function unknown]; Region: COG3949 632335002298 Bacitracin resistance protein BacA; Region: BacA; pfam02673 632335002299 UGMP family protein; Validated; Region: PRK09604 632335002300 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 632335002301 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 632335002302 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 632335002303 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632335002304 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335002305 Zn2+ binding site [ion binding]; other site 632335002306 Mg2+ binding site [ion binding]; other site 632335002307 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 632335002308 elongation factor G; Reviewed; Region: PRK12740 632335002309 G1 box; other site 632335002310 putative GEF interaction site [polypeptide binding]; other site 632335002311 GTP/Mg2+ binding site [chemical binding]; other site 632335002312 Switch I region; other site 632335002313 G2 box; other site 632335002314 G3 box; other site 632335002315 Switch II region; other site 632335002316 G4 box; other site 632335002317 G5 box; other site 632335002318 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 632335002319 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 632335002320 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 632335002321 Probable zinc-binding domain; Region: zf-trcl; pfam13451 632335002322 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 632335002323 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 632335002324 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 632335002325 NodB motif; other site 632335002326 active site 632335002327 catalytic site [active] 632335002328 Zn binding site [ion binding]; other site 632335002329 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 632335002330 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 632335002331 UvrB/uvrC motif; Region: UVR; pfam02151 632335002332 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 632335002333 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 632335002334 ADP binding site [chemical binding]; other site 632335002335 phosphagen binding site; other site 632335002336 substrate specificity loop; other site 632335002337 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 632335002338 Clp amino terminal domain; Region: Clp_N; pfam02861 632335002339 Clp amino terminal domain; Region: Clp_N; pfam02861 632335002340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335002341 Walker A motif; other site 632335002342 ATP binding site [chemical binding]; other site 632335002343 Walker B motif; other site 632335002344 arginine finger; other site 632335002345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335002346 Walker A motif; other site 632335002347 ATP binding site [chemical binding]; other site 632335002348 Walker B motif; other site 632335002349 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 632335002350 6-phosphofructokinase; Provisional; Region: PRK14072 632335002351 active site 632335002352 ADP/pyrophosphate binding site [chemical binding]; other site 632335002353 dimerization interface [polypeptide binding]; other site 632335002354 allosteric effector site; other site 632335002355 fructose-1,6-bisphosphate binding site; other site 632335002356 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 632335002357 Domain of unknown function (DUF814); Region: DUF814; pfam05670 632335002358 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 632335002359 O-Antigen ligase; Region: Wzy_C; cl04850 632335002360 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 632335002361 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 632335002362 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335002363 putative homodimer interface [polypeptide binding]; other site 632335002364 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632335002365 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 632335002366 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632335002367 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 632335002368 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 632335002369 rRNA interaction site [nucleotide binding]; other site 632335002370 S8 interaction site; other site 632335002371 putative laminin-1 binding site; other site 632335002372 elongation factor Ts; Reviewed; Region: tsf; PRK12332 632335002373 UBA/TS-N domain; Region: UBA; pfam00627 632335002374 Elongation factor TS; Region: EF_TS; pfam00889 632335002375 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 632335002376 putative nucleotide binding site [chemical binding]; other site 632335002377 uridine monophosphate binding site [chemical binding]; other site 632335002378 homohexameric interface [polypeptide binding]; other site 632335002379 ribosome recycling factor; Reviewed; Region: frr; PRK00083 632335002380 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 632335002381 hinge region; other site 632335002382 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 632335002383 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 632335002384 catalytic residue [active] 632335002385 putative FPP diphosphate binding site; other site 632335002386 putative FPP binding hydrophobic cleft; other site 632335002387 dimer interface [polypeptide binding]; other site 632335002388 putative IPP diphosphate binding site; other site 632335002389 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 632335002390 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 632335002391 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 632335002392 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 632335002393 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 632335002394 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 632335002395 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 632335002396 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 632335002397 active site 632335002398 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 632335002399 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 632335002400 putative substrate binding region [chemical binding]; other site 632335002401 GcpE protein; Region: GcpE; pfam04551 632335002402 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 632335002403 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 632335002404 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 632335002405 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 632335002406 Ligand binding site; other site 632335002407 Putative Catalytic site; other site 632335002408 DXD motif; other site 632335002409 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 632335002410 DNA polymerase III PolC; Validated; Region: polC; PRK00448 632335002411 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 632335002412 generic binding surface II; other site 632335002413 generic binding surface I; other site 632335002414 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632335002415 active site 632335002416 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 632335002417 active site 632335002418 catalytic site [active] 632335002419 substrate binding site [chemical binding]; other site 632335002420 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 632335002421 Thiamine pyrophosphokinase; Region: TPK; cd07995 632335002422 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 632335002423 active site 632335002424 dimerization interface [polypeptide binding]; other site 632335002425 thiamine binding site [chemical binding]; other site 632335002426 Predicted membrane protein [Function unknown]; Region: COG2261 632335002427 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632335002428 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 632335002429 Walker A/P-loop; other site 632335002430 ATP binding site [chemical binding]; other site 632335002431 Q-loop/lid; other site 632335002432 ABC transporter signature motif; other site 632335002433 Walker B; other site 632335002434 D-loop; other site 632335002435 H-loop/switch region; other site 632335002436 TOBE domain; Region: TOBE; pfam03459 632335002437 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 632335002438 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632335002439 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 632335002440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335002441 Walker A/P-loop; other site 632335002442 ATP binding site [chemical binding]; other site 632335002443 Q-loop/lid; other site 632335002444 ABC transporter signature motif; other site 632335002445 Walker B; other site 632335002446 D-loop; other site 632335002447 H-loop/switch region; other site 632335002448 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 632335002449 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 632335002450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 632335002451 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632335002452 Peptidase family M23; Region: Peptidase_M23; pfam01551 632335002453 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 632335002454 C-terminal peptidase (prc); Region: prc; TIGR00225 632335002455 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 632335002456 protein binding site [polypeptide binding]; other site 632335002457 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 632335002458 Catalytic dyad [active] 632335002459 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632335002460 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632335002461 Peptidase family M23; Region: Peptidase_M23; pfam01551 632335002462 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 632335002463 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632335002464 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 632335002465 germination protein YpeB; Region: spore_YpeB; TIGR02889 632335002466 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 632335002467 germination protease; Provisional; Region: PRK12362 632335002468 stage II sporulation protein P; Region: spore_II_P; TIGR02867 632335002469 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 632335002470 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 632335002471 active site 632335002472 Int/Topo IB signature motif; other site 632335002473 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632335002474 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 632335002475 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 632335002476 catalytic triad [active] 632335002477 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 632335002478 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 632335002479 ligand binding site [chemical binding]; other site 632335002480 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 632335002481 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 632335002482 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 632335002483 Walker A/P-loop; other site 632335002484 ATP binding site [chemical binding]; other site 632335002485 Q-loop/lid; other site 632335002486 ABC transporter signature motif; other site 632335002487 Walker B; other site 632335002488 D-loop; other site 632335002489 H-loop/switch region; other site 632335002490 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 632335002491 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632335002492 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 632335002493 TM-ABC transporter signature motif; other site 632335002494 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632335002495 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 632335002496 TM-ABC transporter signature motif; other site 632335002497 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632335002498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632335002499 DNA-binding site [nucleotide binding]; DNA binding site 632335002500 UTRA domain; Region: UTRA; pfam07702 632335002501 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 632335002502 active site 632335002503 catalytic motif [active] 632335002504 Zn binding site [ion binding]; other site 632335002505 XapX domain; Region: XapX; TIGR03510 632335002506 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 632335002507 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 632335002508 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 632335002509 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 632335002510 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 632335002511 intersubunit interface [polypeptide binding]; other site 632335002512 active site 632335002513 catalytic residue [active] 632335002514 phosphopentomutase; Provisional; Region: PRK05362 632335002515 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 632335002516 purine nucleoside phosphorylase; Provisional; Region: PRK08202 632335002517 Response regulator receiver domain; Region: Response_reg; pfam00072 632335002518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335002519 active site 632335002520 phosphorylation site [posttranslational modification] 632335002521 intermolecular recognition site; other site 632335002522 dimerization interface [polypeptide binding]; other site 632335002523 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 632335002524 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 632335002525 putative binding surface; other site 632335002526 active site 632335002527 P2 response regulator binding domain; Region: P2; pfam07194 632335002528 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 632335002529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335002530 ATP binding site [chemical binding]; other site 632335002531 Mg2+ binding site [ion binding]; other site 632335002532 G-X-G motif; other site 632335002533 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632335002534 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 632335002535 CHASE3 domain; Region: CHASE3; cl05000 632335002536 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 632335002537 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 632335002538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335002539 dimerization interface [polypeptide binding]; other site 632335002540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632335002541 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632335002542 dimer interface [polypeptide binding]; other site 632335002543 putative CheW interface [polypeptide binding]; other site 632335002544 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 632335002545 YtxC-like family; Region: YtxC; pfam08812 632335002546 Trp repressor protein; Region: Trp_repressor; cl17266 632335002547 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 632335002548 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 632335002549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 632335002550 Haemagglutinin; Region: Hemagglutinin; pfam00509 632335002551 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 632335002552 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632335002553 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632335002554 protein binding site [polypeptide binding]; other site 632335002555 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 632335002556 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632335002557 active site 632335002558 HIGH motif; other site 632335002559 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632335002560 active site 632335002561 KMSKS motif; other site 632335002562 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335002563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335002564 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335002565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335002566 3D domain; Region: 3D; cl01439 632335002567 Uncharacterized conserved protein [Function unknown]; Region: COG3391 632335002568 Putative amidase domain; Region: Amidase_6; pfam12671 632335002569 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632335002570 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 632335002571 active site 632335002572 NAD binding site [chemical binding]; other site 632335002573 metal binding site [ion binding]; metal-binding site 632335002574 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632335002575 Predicted dehydrogenase [General function prediction only]; Region: COG0579 632335002576 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 632335002577 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632335002578 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 632335002579 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 632335002580 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 632335002581 Found in ATP-dependent protease La (LON); Region: LON; smart00464 632335002582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335002583 Walker A motif; other site 632335002584 ATP binding site [chemical binding]; other site 632335002585 Walker B motif; other site 632335002586 arginine finger; other site 632335002587 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 632335002588 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 632335002589 G1 box; other site 632335002590 GTP/Mg2+ binding site [chemical binding]; other site 632335002591 Switch I region; other site 632335002592 G2 box; other site 632335002593 G3 box; other site 632335002594 Switch II region; other site 632335002595 G4 box; other site 632335002596 G5 box; other site 632335002597 Uncharacterized conserved protein [Function unknown]; Region: COG1683 632335002598 Sensory domain found in PocR; Region: PocR; pfam10114 632335002599 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 632335002600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335002601 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632335002602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335002603 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 632335002604 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 632335002605 dimer interface [polypeptide binding]; other site 632335002606 active site 632335002607 galactokinase; Provisional; Region: PRK05322 632335002608 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 632335002609 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632335002610 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632335002611 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 632335002612 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 632335002613 NAD binding site [chemical binding]; other site 632335002614 homodimer interface [polypeptide binding]; other site 632335002615 active site 632335002616 substrate binding site [chemical binding]; other site 632335002617 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 632335002618 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632335002619 active site 632335002620 HIGH motif; other site 632335002621 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632335002622 active site 632335002623 KMSKS motif; other site 632335002624 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 632335002625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632335002626 DNA-binding site [nucleotide binding]; DNA binding site 632335002627 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335002628 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 632335002629 Walker A/P-loop; other site 632335002630 ATP binding site [chemical binding]; other site 632335002631 Q-loop/lid; other site 632335002632 ABC transporter signature motif; other site 632335002633 Walker B; other site 632335002634 D-loop; other site 632335002635 H-loop/switch region; other site 632335002636 putative DNA-binding protein; Validated; Region: PRK00118 632335002637 signal recognition particle protein; Provisional; Region: PRK10867 632335002638 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 632335002639 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 632335002640 P loop; other site 632335002641 GTP binding site [chemical binding]; other site 632335002642 Signal peptide binding domain; Region: SRP_SPB; pfam02978 632335002643 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 632335002644 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 632335002645 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 632335002646 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 632335002647 RimM N-terminal domain; Region: RimM; pfam01782 632335002648 PRC-barrel domain; Region: PRC; pfam05239 632335002649 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 632335002650 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 632335002651 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 632335002652 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 632335002653 GTP/Mg2+ binding site [chemical binding]; other site 632335002654 G4 box; other site 632335002655 G5 box; other site 632335002656 G1 box; other site 632335002657 Switch I region; other site 632335002658 G2 box; other site 632335002659 G3 box; other site 632335002660 Switch II region; other site 632335002661 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 632335002662 RNA/DNA hybrid binding site [nucleotide binding]; other site 632335002663 active site 632335002664 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 632335002665 hypothetical protein; Reviewed; Region: PRK12497 632335002666 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 632335002667 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 632335002668 NAD binding site [chemical binding]; other site 632335002669 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 632335002670 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 632335002671 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 632335002672 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 632335002673 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 632335002674 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 632335002675 hypothetical protein; Provisional; Region: PRK00955 632335002676 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 632335002677 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 632335002678 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 632335002679 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 632335002680 homodimer interface [polypeptide binding]; other site 632335002681 NADP binding site [chemical binding]; other site 632335002682 substrate binding site [chemical binding]; other site 632335002683 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 632335002684 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632335002685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335002686 FeS/SAM binding site; other site 632335002687 TRAM domain; Region: TRAM; pfam01938 632335002688 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 632335002689 competence damage-inducible protein A; Provisional; Region: PRK00549 632335002690 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 632335002691 putative MPT binding site; other site 632335002692 Competence-damaged protein; Region: CinA; pfam02464 632335002693 recombinase A; Provisional; Region: recA; PRK09354 632335002694 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 632335002695 hexamer interface [polypeptide binding]; other site 632335002696 Walker A motif; other site 632335002697 ATP binding site [chemical binding]; other site 632335002698 Walker B motif; other site 632335002699 RecX family; Region: RecX; cl00936 632335002700 phosphodiesterase; Provisional; Region: PRK12704 632335002701 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 632335002702 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335002703 Zn2+ binding site [ion binding]; other site 632335002704 Mg2+ binding site [ion binding]; other site 632335002705 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 632335002706 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632335002707 putative active site [active] 632335002708 metal binding site [ion binding]; metal-binding site 632335002709 homodimer binding site [polypeptide binding]; other site 632335002710 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 632335002711 NTPase; Region: NTPase_1; cl17478 632335002712 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 632335002713 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 632335002714 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 632335002715 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 632335002716 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 632335002717 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 632335002718 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 632335002719 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 632335002720 Asp23 family; Region: Asp23; pfam03780 632335002721 Asp23 family; Region: Asp23; pfam03780 632335002722 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 632335002723 transcription antitermination factor NusB; Region: nusB; TIGR01951 632335002724 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 632335002725 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 632335002726 generic binding surface II; other site 632335002727 generic binding surface I; other site 632335002728 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 632335002729 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 632335002730 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 632335002731 substrate binding pocket [chemical binding]; other site 632335002732 chain length determination region; other site 632335002733 substrate-Mg2+ binding site; other site 632335002734 catalytic residues [active] 632335002735 aspartate-rich region 1; other site 632335002736 active site lid residues [active] 632335002737 aspartate-rich region 2; other site 632335002738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335002739 putative substrate translocation pore; other site 632335002740 stage V sporulation protein T; Region: spore_V_T; TIGR02851 632335002741 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 632335002742 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 632335002743 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632335002744 dimer interface [polypeptide binding]; other site 632335002745 PYR/PP interface [polypeptide binding]; other site 632335002746 TPP binding site [chemical binding]; other site 632335002747 substrate binding site [chemical binding]; other site 632335002748 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 632335002749 TPP-binding site; other site 632335002750 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 632335002751 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632335002752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632335002753 acyl-activating enzyme (AAE) consensus motif; other site 632335002754 AMP binding site [chemical binding]; other site 632335002755 active site 632335002756 CoA binding site [chemical binding]; other site 632335002757 Predicted membrane protein [Function unknown]; Region: COG2323 632335002758 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 632335002759 CoA binding domain; Region: CoA_binding_2; pfam13380 632335002760 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 632335002761 active site 632335002762 catalytic residues [active] 632335002763 hypothetical protein; Validated; Region: PRK00068 632335002764 Protein of unknown function DUF89; Region: DUF89; cl15397 632335002765 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 632335002766 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 632335002767 active site 632335002768 Zn binding site [ion binding]; other site 632335002769 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 632335002770 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 632335002771 hypothetical protein; Provisional; Region: PRK11820 632335002772 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 632335002773 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 632335002774 hypothetical protein; Provisional; Region: PRK04323 632335002775 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 632335002776 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 632335002777 catalytic site [active] 632335002778 G-X2-G-X-G-K; other site 632335002779 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 632335002780 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 632335002781 Flavoprotein; Region: Flavoprotein; pfam02441 632335002782 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 632335002783 primosome assembly protein PriA; Validated; Region: PRK05580 632335002784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335002785 ATP binding site [chemical binding]; other site 632335002786 putative Mg++ binding site [ion binding]; other site 632335002787 helicase superfamily c-terminal domain; Region: HELICc; smart00490 632335002788 ATP-binding site [chemical binding]; other site 632335002789 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 632335002790 active site 632335002791 catalytic residues [active] 632335002792 metal binding site [ion binding]; metal-binding site 632335002793 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 632335002794 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 632335002795 putative active site [active] 632335002796 substrate binding site [chemical binding]; other site 632335002797 putative cosubstrate binding site; other site 632335002798 catalytic site [active] 632335002799 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 632335002800 substrate binding site [chemical binding]; other site 632335002801 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 632335002802 NusB family; Region: NusB; pfam01029 632335002803 16S rRNA methyltransferase B; Provisional; Region: PRK14902 632335002804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335002805 S-adenosylmethionine binding site [chemical binding]; other site 632335002806 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 632335002807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335002808 FeS/SAM binding site; other site 632335002809 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 632335002810 Protein phosphatase 2C; Region: PP2C; pfam00481 632335002811 active site 632335002812 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632335002813 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632335002814 active site 632335002815 ATP binding site [chemical binding]; other site 632335002816 substrate binding site [chemical binding]; other site 632335002817 activation loop (A-loop); other site 632335002818 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632335002819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 632335002820 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632335002821 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632335002822 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632335002823 GTPase RsgA; Reviewed; Region: PRK00098 632335002824 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 632335002825 RNA binding site [nucleotide binding]; other site 632335002826 homodimer interface [polypeptide binding]; other site 632335002827 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 632335002828 GTP/Mg2+ binding site [chemical binding]; other site 632335002829 G4 box; other site 632335002830 G5 box; other site 632335002831 G1 box; other site 632335002832 Switch I region; other site 632335002833 G2 box; other site 632335002834 G3 box; other site 632335002835 Switch II region; other site 632335002836 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 632335002837 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 632335002838 substrate binding site [chemical binding]; other site 632335002839 hexamer interface [polypeptide binding]; other site 632335002840 metal binding site [ion binding]; metal-binding site 632335002841 ribosome maturation protein RimP; Reviewed; Region: PRK00092 632335002842 Sm and related proteins; Region: Sm_like; cl00259 632335002843 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 632335002844 putative oligomer interface [polypeptide binding]; other site 632335002845 putative RNA binding site [nucleotide binding]; other site 632335002846 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 632335002847 NusA N-terminal domain; Region: NusA_N; pfam08529 632335002848 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 632335002849 RNA binding site [nucleotide binding]; other site 632335002850 homodimer interface [polypeptide binding]; other site 632335002851 NusA-like KH domain; Region: KH_5; pfam13184 632335002852 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 632335002853 G-X-X-G motif; other site 632335002854 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 632335002855 putative RNA binding cleft [nucleotide binding]; other site 632335002856 translation initiation factor IF-2; Validated; Region: infB; PRK05306 632335002857 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 632335002858 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 632335002859 G1 box; other site 632335002860 putative GEF interaction site [polypeptide binding]; other site 632335002861 GTP/Mg2+ binding site [chemical binding]; other site 632335002862 Switch I region; other site 632335002863 G2 box; other site 632335002864 G3 box; other site 632335002865 Switch II region; other site 632335002866 G4 box; other site 632335002867 G5 box; other site 632335002868 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 632335002869 Translation-initiation factor 2; Region: IF-2; pfam11987 632335002870 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 632335002871 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 632335002872 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 632335002873 DHH family; Region: DHH; pfam01368 632335002874 DHHA1 domain; Region: DHHA1; pfam02272 632335002875 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 632335002876 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 632335002877 RNA binding site [nucleotide binding]; other site 632335002878 active site 632335002879 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 632335002880 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 632335002881 active site 632335002882 Riboflavin kinase; Region: Flavokinase; pfam01687 632335002883 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 632335002884 16S/18S rRNA binding site [nucleotide binding]; other site 632335002885 S13e-L30e interaction site [polypeptide binding]; other site 632335002886 25S rRNA binding site [nucleotide binding]; other site 632335002887 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 632335002888 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 632335002889 RNase E interface [polypeptide binding]; other site 632335002890 trimer interface [polypeptide binding]; other site 632335002891 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 632335002892 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 632335002893 RNase E interface [polypeptide binding]; other site 632335002894 trimer interface [polypeptide binding]; other site 632335002895 active site 632335002896 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 632335002897 putative nucleic acid binding region [nucleotide binding]; other site 632335002898 G-X-X-G motif; other site 632335002899 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 632335002900 RNA binding site [nucleotide binding]; other site 632335002901 domain interface; other site 632335002902 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 632335002903 Uncharacterized conserved protein [Function unknown]; Region: COG2966 632335002904 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 632335002905 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 632335002906 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 632335002907 dimer interface [polypeptide binding]; other site 632335002908 active site 632335002909 glycine-pyridoxal phosphate binding site [chemical binding]; other site 632335002910 folate binding site [chemical binding]; other site 632335002911 recombination factor protein RarA; Reviewed; Region: PRK13342 632335002912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335002913 Walker A motif; other site 632335002914 ATP binding site [chemical binding]; other site 632335002915 Walker B motif; other site 632335002916 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 632335002917 arginine finger; other site 632335002918 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 632335002919 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 632335002920 Malic enzyme, N-terminal domain; Region: malic; pfam00390 632335002921 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 632335002922 putative NAD(P) binding site [chemical binding]; other site 632335002923 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 632335002924 transcription termination factor Rho; Provisional; Region: PRK12608 632335002925 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632335002926 RNA binding site [nucleotide binding]; other site 632335002927 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632335002928 Walker A motif; other site 632335002929 ATP binding site [chemical binding]; other site 632335002930 Walker B motif; other site 632335002931 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 632335002932 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632335002933 active site 632335002934 metal binding site [ion binding]; metal-binding site 632335002935 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 632335002936 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 632335002937 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632335002938 minor groove reading motif; other site 632335002939 helix-hairpin-helix signature motif; other site 632335002940 substrate binding pocket [chemical binding]; other site 632335002941 active site 632335002942 Protease prsW family; Region: PrsW-protease; pfam13367 632335002943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335002944 putative substrate translocation pore; other site 632335002945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632335002946 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 632335002947 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 632335002948 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 632335002949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335002950 S-adenosylmethionine binding site [chemical binding]; other site 632335002951 peptide chain release factor 1; Validated; Region: prfA; PRK00591 632335002952 This domain is found in peptide chain release factors; Region: PCRF; smart00937 632335002953 RF-1 domain; Region: RF-1; pfam00472 632335002954 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 632335002955 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 632335002956 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 632335002957 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 632335002958 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 632335002959 ligand binding site [chemical binding]; other site 632335002960 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 632335002961 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 632335002962 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 632335002963 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 632335002964 Low molecular weight phosphatase family; Region: LMWPc; cd00115 632335002965 active site 632335002966 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 632335002967 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 632335002968 feedback inhibition sensing region; other site 632335002969 homohexameric interface [polypeptide binding]; other site 632335002970 nucleotide binding site [chemical binding]; other site 632335002971 N-acetyl-L-glutamate binding site [chemical binding]; other site 632335002972 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 632335002973 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632335002974 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 632335002975 AMIN domain; Region: AMIN; pfam11741 632335002976 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 632335002977 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632335002978 active site 632335002979 metal binding site [ion binding]; metal-binding site 632335002980 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 632335002981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335002982 active site 632335002983 motif I; other site 632335002984 motif II; other site 632335002985 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 632335002986 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 632335002987 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 632335002988 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 632335002989 NADH dehydrogenase; Region: NADHdh; cl00469 632335002990 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 632335002991 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 632335002992 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 632335002993 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 632335002994 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 632335002995 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632335002996 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 632335002997 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 632335002998 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 632335002999 G1 box; other site 632335003000 GTP/Mg2+ binding site [chemical binding]; other site 632335003001 G2 box; other site 632335003002 G3 box; other site 632335003003 Switch II region; other site 632335003004 G4 box; other site 632335003005 G5 box; other site 632335003006 Acylphosphatase; Region: Acylphosphatase; pfam00708 632335003007 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 632335003008 HypF finger; Region: zf-HYPF; pfam07503 632335003009 HypF finger; Region: zf-HYPF; pfam07503 632335003010 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 632335003011 HupF/HypC family; Region: HupF_HypC; pfam01455 632335003012 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 632335003013 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 632335003014 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 632335003015 dimerization interface [polypeptide binding]; other site 632335003016 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 632335003017 ATP binding site [chemical binding]; other site 632335003018 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 632335003019 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632335003020 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632335003021 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 632335003022 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632335003023 dimer interface [polypeptide binding]; other site 632335003024 PYR/PP interface [polypeptide binding]; other site 632335003025 TPP binding site [chemical binding]; other site 632335003026 substrate binding site [chemical binding]; other site 632335003027 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 632335003028 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632335003029 TPP-binding site [chemical binding]; other site 632335003030 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 632335003031 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 632335003032 VanW like protein; Region: VanW; pfam04294 632335003033 G5 domain; Region: G5; pfam07501 632335003034 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 632335003035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 632335003036 Haemolysin XhlA; Region: XhlA; pfam10779 632335003037 Predicted transcriptional regulator [Transcription]; Region: COG4189 632335003038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632335003039 dimerization interface [polypeptide binding]; other site 632335003040 putative DNA binding site [nucleotide binding]; other site 632335003041 putative Zn2+ binding site [ion binding]; other site 632335003042 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 632335003043 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 632335003044 alpha-galactosidase; Provisional; Region: PRK15076 632335003045 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 632335003046 NAD binding site [chemical binding]; other site 632335003047 sugar binding site [chemical binding]; other site 632335003048 divalent metal binding site [ion binding]; other site 632335003049 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 632335003050 dimer interface [polypeptide binding]; other site 632335003051 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 632335003052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632335003053 Coenzyme A binding pocket [chemical binding]; other site 632335003054 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 632335003055 active site 632335003056 putative DNA-binding cleft [nucleotide binding]; other site 632335003057 dimer interface [polypeptide binding]; other site 632335003058 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 632335003059 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 632335003060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335003061 Walker A motif; other site 632335003062 ATP binding site [chemical binding]; other site 632335003063 Walker B motif; other site 632335003064 arginine finger; other site 632335003065 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 632335003066 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 632335003067 Ligand Binding Site [chemical binding]; other site 632335003068 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 632335003069 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 632335003070 hypothetical protein; Provisional; Region: PRK14553 632335003071 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 632335003072 GTPase CgtA; Reviewed; Region: obgE; PRK12297 632335003073 GTP1/OBG; Region: GTP1_OBG; pfam01018 632335003074 Obg GTPase; Region: Obg; cd01898 632335003075 G1 box; other site 632335003076 GTP/Mg2+ binding site [chemical binding]; other site 632335003077 Switch I region; other site 632335003078 G2 box; other site 632335003079 G3 box; other site 632335003080 Switch II region; other site 632335003081 G4 box; other site 632335003082 G5 box; other site 632335003083 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 632335003084 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 632335003085 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 632335003086 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632335003087 homodimer interface [polypeptide binding]; other site 632335003088 substrate-cofactor binding pocket; other site 632335003089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335003090 catalytic residue [active] 632335003091 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 632335003092 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 632335003093 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 632335003094 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 632335003095 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 632335003096 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 632335003097 active site 632335003098 dimer interface [polypeptide binding]; other site 632335003099 aspartate aminotransferase; Provisional; Region: PRK05764 632335003100 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632335003101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335003102 homodimer interface [polypeptide binding]; other site 632335003103 catalytic residue [active] 632335003104 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 632335003105 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 632335003106 tetramer interface [polypeptide binding]; other site 632335003107 active site 632335003108 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 632335003109 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 632335003110 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632335003111 dimerization interface [polypeptide binding]; other site 632335003112 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632335003113 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632335003114 dimer interface [polypeptide binding]; other site 632335003115 putative CheW interface [polypeptide binding]; other site 632335003116 reverse gyrase; Reviewed; Region: PRK09401 632335003117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335003118 ATP binding site [chemical binding]; other site 632335003119 TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove; Region: TOPRIM_TopoIA_RevGyr; cd03361 632335003120 active site 632335003121 putative interdomain interaction site [polypeptide binding]; other site 632335003122 putative metal-binding site [ion binding]; other site 632335003123 putative nucleotide binding site [chemical binding]; other site 632335003124 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 632335003125 domain I; other site 632335003126 DNA binding groove [nucleotide binding] 632335003127 phosphate binding site [ion binding]; other site 632335003128 domain II; other site 632335003129 domain III; other site 632335003130 nucleotide binding site [chemical binding]; other site 632335003131 catalytic site [active] 632335003132 domain IV; other site 632335003133 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 632335003134 putative allosteric regulatory site; other site 632335003135 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 632335003136 putative allosteric regulatory residue; other site 632335003137 dihydrodipicolinate reductase; Provisional; Region: PRK00048 632335003138 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 632335003139 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 632335003140 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 632335003141 dihydrodipicolinate synthase; Region: dapA; TIGR00674 632335003142 dimer interface [polypeptide binding]; other site 632335003143 active site 632335003144 catalytic residue [active] 632335003145 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 632335003146 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632335003147 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 632335003148 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 632335003149 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632335003150 active site 632335003151 NTP binding site [chemical binding]; other site 632335003152 metal binding triad [ion binding]; metal-binding site 632335003153 antibiotic binding site [chemical binding]; other site 632335003154 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 632335003155 homotrimer interaction site [polypeptide binding]; other site 632335003156 zinc binding site [ion binding]; other site 632335003157 CDP-binding sites; other site 632335003158 NurA domain; Region: NurA; pfam09376 632335003159 HerA helicase [Replication, recombination, and repair]; Region: COG0433 632335003160 Domain of unknown function DUF87; Region: DUF87; pfam01935 632335003161 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 632335003162 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 632335003163 active site 632335003164 metal binding site [ion binding]; metal-binding site 632335003165 DNA binding site [nucleotide binding] 632335003166 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 632335003167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335003168 Walker A/P-loop; other site 632335003169 ATP binding site [chemical binding]; other site 632335003170 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 632335003171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335003172 ABC transporter signature motif; other site 632335003173 Walker B; other site 632335003174 D-loop; other site 632335003175 H-loop/switch region; other site 632335003176 hypothetical protein; Validated; Region: PRK00153 632335003177 recombination protein RecR; Reviewed; Region: recR; PRK00076 632335003178 RecR protein; Region: RecR; pfam02132 632335003179 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 632335003180 putative active site [active] 632335003181 putative metal-binding site [ion binding]; other site 632335003182 tetramer interface [polypeptide binding]; other site 632335003183 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632335003184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632335003185 NAD(P) binding site [chemical binding]; other site 632335003186 active site 632335003187 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 632335003188 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 632335003189 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 632335003190 active site 632335003191 tetramer interface; other site 632335003192 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 632335003193 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 632335003194 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 632335003195 active site 1 [active] 632335003196 active site 2 [active] 632335003197 putative phosphate acyltransferase; Provisional; Region: PRK05331 632335003198 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 632335003199 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 632335003200 dimer interface [polypeptide binding]; other site 632335003201 active site 632335003202 CoA binding pocket [chemical binding]; other site 632335003203 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 632335003204 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 632335003205 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 632335003206 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 632335003207 NAD(P) binding site [chemical binding]; other site 632335003208 homotetramer interface [polypeptide binding]; other site 632335003209 homodimer interface [polypeptide binding]; other site 632335003210 active site 632335003211 acyl carrier protein; Provisional; Region: acpP; PRK00982 632335003212 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 632335003213 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 632335003214 dimer interface [polypeptide binding]; other site 632335003215 active site 632335003216 ribonuclease III; Reviewed; Region: rnc; PRK00102 632335003217 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 632335003218 dimerization interface [polypeptide binding]; other site 632335003219 active site 632335003220 metal binding site [ion binding]; metal-binding site 632335003221 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 632335003222 dsRNA binding site [nucleotide binding]; other site 632335003223 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 632335003224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335003225 FeS/SAM binding site; other site 632335003226 PBP superfamily domain; Region: PBP_like_2; cl17296 632335003227 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632335003228 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 632335003229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335003230 dimer interface [polypeptide binding]; other site 632335003231 conserved gate region; other site 632335003232 putative PBP binding loops; other site 632335003233 ABC-ATPase subunit interface; other site 632335003234 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 632335003235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335003236 dimer interface [polypeptide binding]; other site 632335003237 conserved gate region; other site 632335003238 putative PBP binding loops; other site 632335003239 ABC-ATPase subunit interface; other site 632335003240 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 632335003241 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 632335003242 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632335003243 dimer interface [polypeptide binding]; other site 632335003244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335003245 catalytic residue [active] 632335003246 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 632335003247 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 632335003248 Walker A/P-loop; other site 632335003249 ATP binding site [chemical binding]; other site 632335003250 Q-loop/lid; other site 632335003251 ABC transporter signature motif; other site 632335003252 Walker B; other site 632335003253 D-loop; other site 632335003254 H-loop/switch region; other site 632335003255 NIL domain; Region: NIL; pfam09383 632335003256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335003257 dimer interface [polypeptide binding]; other site 632335003258 conserved gate region; other site 632335003259 ABC-ATPase subunit interface; other site 632335003260 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 632335003261 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 632335003262 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 632335003263 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 632335003264 Walker A/P-loop; other site 632335003265 ATP binding site [chemical binding]; other site 632335003266 Q-loop/lid; other site 632335003267 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 632335003268 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 632335003269 ABC transporter signature motif; other site 632335003270 Walker B; other site 632335003271 D-loop; other site 632335003272 H-loop/switch region; other site 632335003273 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 632335003274 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 632335003275 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 632335003276 P loop; other site 632335003277 GTP binding site [chemical binding]; other site 632335003278 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 632335003279 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 632335003280 ligand binding site [chemical binding]; other site 632335003281 flexible hinge region; other site 632335003282 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 632335003283 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 632335003284 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632335003285 hybrid cluster protein; Provisional; Region: PRK05290 632335003286 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632335003287 ACS interaction site; other site 632335003288 CODH interaction site; other site 632335003289 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 632335003290 hybrid metal cluster; other site 632335003291 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 632335003292 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 632335003293 ATP-grasp domain; Region: ATP-grasp; pfam02222 632335003294 AIR carboxylase; Region: AIRC; pfam00731 632335003295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335003296 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 632335003297 putative substrate translocation pore; other site 632335003298 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 632335003299 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 632335003300 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 632335003301 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 632335003302 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632335003303 substrate binding pocket [chemical binding]; other site 632335003304 membrane-bound complex binding site; other site 632335003305 hinge residues; other site 632335003306 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 632335003307 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 632335003308 Walker A/P-loop; other site 632335003309 ATP binding site [chemical binding]; other site 632335003310 Q-loop/lid; other site 632335003311 ABC transporter signature motif; other site 632335003312 Walker B; other site 632335003313 D-loop; other site 632335003314 H-loop/switch region; other site 632335003315 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 632335003316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335003317 dimer interface [polypeptide binding]; other site 632335003318 conserved gate region; other site 632335003319 putative PBP binding loops; other site 632335003320 ABC-ATPase subunit interface; other site 632335003321 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 632335003322 thiS-thiF/thiG interaction site; other site 632335003323 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 632335003324 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 632335003325 ATP binding site [chemical binding]; other site 632335003326 substrate interface [chemical binding]; other site 632335003327 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 632335003328 MPN+ (JAMM) motif; other site 632335003329 Zinc-binding site [ion binding]; other site 632335003330 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 632335003331 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 632335003332 4Fe-4S binding domain; Region: Fer4; pfam00037 632335003333 4Fe-4S binding domain; Region: Fer4; pfam00037 632335003334 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 632335003335 CPxP motif; other site 632335003336 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 632335003337 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632335003338 homodimer interface [polypeptide binding]; other site 632335003339 substrate-cofactor binding pocket; other site 632335003340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335003341 catalytic residue [active] 632335003342 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 632335003343 L-aspartate oxidase; Provisional; Region: PRK06175 632335003344 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632335003345 Ferredoxin [Energy production and conversion]; Region: COG1146 632335003346 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 632335003347 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 632335003348 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 632335003349 Active Sites [active] 632335003350 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 632335003351 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 632335003352 CysD dimerization site [polypeptide binding]; other site 632335003353 G1 box; other site 632335003354 putative GEF interaction site [polypeptide binding]; other site 632335003355 GTP/Mg2+ binding site [chemical binding]; other site 632335003356 Switch I region; other site 632335003357 G2 box; other site 632335003358 G3 box; other site 632335003359 Switch II region; other site 632335003360 G4 box; other site 632335003361 G5 box; other site 632335003362 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 632335003363 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 632335003364 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 632335003365 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 632335003366 tRNA; other site 632335003367 putative tRNA binding site [nucleotide binding]; other site 632335003368 putative NADP binding site [chemical binding]; other site 632335003369 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 632335003370 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 632335003371 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 632335003372 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 632335003373 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 632335003374 domain interfaces; other site 632335003375 active site 632335003376 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 632335003377 active site 632335003378 SAM binding site [chemical binding]; other site 632335003379 homodimer interface [polypeptide binding]; other site 632335003380 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 632335003381 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 632335003382 active site 632335003383 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 632335003384 dimer interface [polypeptide binding]; other site 632335003385 active site 632335003386 Schiff base residues; other site 632335003387 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 632335003388 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632335003389 inhibitor-cofactor binding pocket; inhibition site 632335003390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335003391 catalytic residue [active] 632335003392 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 632335003393 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 632335003394 Ligand Binding Site [chemical binding]; other site 632335003395 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 632335003396 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 632335003397 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 632335003398 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 632335003399 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 632335003400 23S rRNA binding site [nucleotide binding]; other site 632335003401 L21 binding site [polypeptide binding]; other site 632335003402 L13 binding site [polypeptide binding]; other site 632335003403 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632335003404 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 632335003405 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 632335003406 hypothetical protein; Provisional; Region: PRK05473 632335003407 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632335003408 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632335003409 active site 632335003410 catalytic tetrad [active] 632335003411 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 632335003412 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632335003413 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 632335003414 Quinolinate synthetase A protein; Region: NadA; pfam02445 632335003415 L-aspartate oxidase; Provisional; Region: PRK06175 632335003416 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 632335003417 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632335003418 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 632335003419 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 632335003420 dimerization interface [polypeptide binding]; other site 632335003421 active site 632335003422 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 632335003423 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 632335003424 putative [4Fe-4S] binding site [ion binding]; other site 632335003425 putative molybdopterin cofactor binding site [chemical binding]; other site 632335003426 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 632335003427 molybdopterin cofactor binding site; other site 632335003428 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 632335003429 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 632335003430 GTP binding site; other site 632335003431 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 632335003432 nudix motif; other site 632335003433 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 632335003434 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 632335003435 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 632335003436 putative RNA binding site [nucleotide binding]; other site 632335003437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335003438 S-adenosylmethionine binding site [chemical binding]; other site 632335003439 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 632335003440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335003441 S-adenosylmethionine binding site [chemical binding]; other site 632335003442 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 632335003443 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 632335003444 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632335003445 RNA binding surface [nucleotide binding]; other site 632335003446 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 632335003447 active site 632335003448 uracil binding [chemical binding]; other site 632335003449 Predicted membrane protein [Function unknown]; Region: COG3601 632335003450 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 632335003451 Asp23 family; Region: Asp23; pfam03780 632335003452 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 632335003453 DAK2 domain; Region: Dak2; pfam02734 632335003454 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 632335003455 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 632335003456 ssDNA binding site; other site 632335003457 generic binding surface II; other site 632335003458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335003459 ATP binding site [chemical binding]; other site 632335003460 putative Mg++ binding site [ion binding]; other site 632335003461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335003462 nucleotide binding region [chemical binding]; other site 632335003463 ATP-binding site [chemical binding]; other site 632335003464 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 632335003465 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 632335003466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335003467 S-adenosylmethionine binding site [chemical binding]; other site 632335003468 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 632335003469 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 632335003470 active site 632335003471 (T/H)XGH motif; other site 632335003472 phosphodiesterase; Provisional; Region: PRK12704 632335003473 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 632335003474 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 632335003475 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 632335003476 active site 632335003477 nucleophile elbow; other site 632335003478 hypothetical protein; Provisional; Region: PRK13670 632335003479 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 632335003480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632335003481 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 632335003482 FAD binding site [chemical binding]; other site 632335003483 homotetramer interface [polypeptide binding]; other site 632335003484 substrate binding pocket [chemical binding]; other site 632335003485 catalytic base [active] 632335003486 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 632335003487 Ligand binding site [chemical binding]; other site 632335003488 Electron transfer flavoprotein domain; Region: ETF; pfam01012 632335003489 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 632335003490 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 632335003491 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 632335003492 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 632335003493 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632335003494 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 632335003495 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 632335003496 inhibitor-cofactor binding pocket; inhibition site 632335003497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335003498 catalytic residue [active] 632335003499 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 632335003500 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632335003501 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 632335003502 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632335003503 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632335003504 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632335003505 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632335003506 putative trimer interface [polypeptide binding]; other site 632335003507 putative CoA binding site [chemical binding]; other site 632335003508 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 632335003509 putative trimer interface [polypeptide binding]; other site 632335003510 putative active site [active] 632335003511 putative substrate binding site [chemical binding]; other site 632335003512 putative CoA binding site [chemical binding]; other site 632335003513 O-Antigen ligase; Region: Wzy_C; pfam04932 632335003514 O-Antigen ligase; Region: Wzy_C; cl04850 632335003515 O-Antigen ligase; Region: Wzy_C; pfam04932 632335003516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335003517 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 632335003518 Transcriptional regulator [Transcription]; Region: LytR; COG1316 632335003519 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 632335003520 Protein of unknown function, DUF624; Region: DUF624; cl02369 632335003521 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 632335003522 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 632335003523 5S rRNA interface [nucleotide binding]; other site 632335003524 CTC domain interface [polypeptide binding]; other site 632335003525 L16 interface [polypeptide binding]; other site 632335003526 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632335003527 argininosuccinate lyase; Provisional; Region: PRK00855 632335003528 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 632335003529 active sites [active] 632335003530 tetramer interface [polypeptide binding]; other site 632335003531 argininosuccinate synthase; Provisional; Region: PRK13820 632335003532 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 632335003533 ANP binding site [chemical binding]; other site 632335003534 Substrate Binding Site II [chemical binding]; other site 632335003535 Substrate Binding Site I [chemical binding]; other site 632335003536 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 632335003537 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 632335003538 active site 632335003539 (T/H)XGH motif; other site 632335003540 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335003541 Zn2+ binding site [ion binding]; other site 632335003542 Mg2+ binding site [ion binding]; other site 632335003543 Transcriptional regulator [Transcription]; Region: LytR; COG1316 632335003544 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 632335003545 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 632335003546 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 632335003547 HIGH motif; other site 632335003548 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632335003549 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 632335003550 active site 632335003551 KMSKS motif; other site 632335003552 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 632335003553 tRNA binding surface [nucleotide binding]; other site 632335003554 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 632335003555 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 632335003556 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 632335003557 SLBB domain; Region: SLBB; pfam10531 632335003558 comEA protein; Region: comE; TIGR01259 632335003559 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 632335003560 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 632335003561 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 632335003562 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 632335003563 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632335003564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335003565 Zn2+ binding site [ion binding]; other site 632335003566 Mg2+ binding site [ion binding]; other site 632335003567 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 632335003568 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 632335003569 active site 632335003570 PHP Thumb interface [polypeptide binding]; other site 632335003571 metal binding site [ion binding]; metal-binding site 632335003572 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 632335003573 generic binding surface II; other site 632335003574 generic binding surface I; other site 632335003575 transcription attenuation protein MtrB; Provisional; Region: PRK13251 632335003576 6-phosphofructokinase; Provisional; Region: PRK03202 632335003577 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 632335003578 active site 632335003579 ADP/pyrophosphate binding site [chemical binding]; other site 632335003580 dimerization interface [polypeptide binding]; other site 632335003581 allosteric effector site; other site 632335003582 fructose-1,6-bisphosphate binding site; other site 632335003583 pyruvate kinase; Provisional; Region: PRK06354 632335003584 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 632335003585 domain interfaces; other site 632335003586 active site 632335003587 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 632335003588 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632335003589 active site 632335003590 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 632335003591 Yqey-like protein; Region: YqeY; pfam09424 632335003592 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632335003593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632335003594 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632335003595 Integrase core domain; Region: rve; pfam00665 632335003596 YabP family; Region: YabP; cl06766 632335003597 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 632335003598 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 632335003599 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 632335003600 PhoH-like protein; Region: PhoH; pfam02562 632335003601 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 632335003602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335003603 Zn2+ binding site [ion binding]; other site 632335003604 Mg2+ binding site [ion binding]; other site 632335003605 metal-binding heat shock protein; Provisional; Region: PRK00016 632335003606 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 632335003607 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 632335003608 active site 632335003609 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 632335003610 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 632335003611 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632335003612 Beta-Casp domain; Region: Beta-Casp; smart01027 632335003613 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632335003614 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 632335003615 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 632335003616 Tetramer interface [polypeptide binding]; other site 632335003617 active site 632335003618 FMN-binding site [chemical binding]; other site 632335003619 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 632335003620 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 632335003621 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 632335003622 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632335003623 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 632335003624 regulatory protein interface [polypeptide binding]; other site 632335003625 regulatory phosphorylation site [posttranslational modification]; other site 632335003626 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 632335003627 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632335003628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335003629 FeS/SAM binding site; other site 632335003630 TRAM domain; Region: TRAM; cl01282 632335003631 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 632335003632 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 632335003633 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 632335003634 dimer interface [polypeptide binding]; other site 632335003635 motif 1; other site 632335003636 active site 632335003637 motif 2; other site 632335003638 motif 3; other site 632335003639 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 632335003640 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 632335003641 putative tRNA-binding site [nucleotide binding]; other site 632335003642 B3/4 domain; Region: B3_4; pfam03483 632335003643 tRNA synthetase B5 domain; Region: B5; smart00874 632335003644 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 632335003645 dimer interface [polypeptide binding]; other site 632335003646 motif 1; other site 632335003647 motif 3; other site 632335003648 motif 2; other site 632335003649 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 632335003650 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 632335003651 Part of AAA domain; Region: AAA_19; pfam13245 632335003652 Family description; Region: UvrD_C_2; pfam13538 632335003653 Divergent PAP2 family; Region: DUF212; pfam02681 632335003654 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 632335003655 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 632335003656 TPP-binding site; other site 632335003657 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 632335003658 PYR/PP interface [polypeptide binding]; other site 632335003659 dimer interface [polypeptide binding]; other site 632335003660 TPP binding site [chemical binding]; other site 632335003661 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632335003662 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 632335003663 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632335003664 RNA binding surface [nucleotide binding]; other site 632335003665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335003666 S-adenosylmethionine binding site [chemical binding]; other site 632335003667 DRTGG domain; Region: DRTGG; pfam07085 632335003668 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 632335003669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335003670 ATP binding site [chemical binding]; other site 632335003671 G-X-G motif; other site 632335003672 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 632335003673 4Fe-4S binding domain; Region: Fer4; pfam00037 632335003674 4Fe-4S binding domain; Region: Fer4; cl02805 632335003675 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 632335003676 Putative Fe-S cluster; Region: FeS; cl17515 632335003677 DRTGG domain; Region: DRTGG; pfam07085 632335003678 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 632335003679 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 632335003680 active site 632335003681 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632335003682 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 632335003683 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 632335003684 putative dimer interface [polypeptide binding]; other site 632335003685 [2Fe-2S] cluster binding site [ion binding]; other site 632335003686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632335003687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335003688 ATP binding site [chemical binding]; other site 632335003689 Mg2+ binding site [ion binding]; other site 632335003690 G-X-G motif; other site 632335003691 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 632335003692 dimer interface [polypeptide binding]; other site 632335003693 [2Fe-2S] cluster binding site [ion binding]; other site 632335003694 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 632335003695 dimer interface [polypeptide binding]; other site 632335003696 [2Fe-2S] cluster binding site [ion binding]; other site 632335003697 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 632335003698 SLBB domain; Region: SLBB; pfam10531 632335003699 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 632335003700 4Fe-4S binding domain; Region: Fer4; pfam00037 632335003701 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632335003702 4Fe-4S binding domain; Region: Fer4; pfam00037 632335003703 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 632335003704 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632335003705 catalytic loop [active] 632335003706 iron binding site [ion binding]; other site 632335003707 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 632335003708 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 632335003709 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 632335003710 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 632335003711 Maf-like protein; Region: Maf; pfam02545 632335003712 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 632335003713 active site 632335003714 dimer interface [polypeptide binding]; other site 632335003715 rod shape-determining protein MreB; Provisional; Region: PRK13927 632335003716 MreB and similar proteins; Region: MreB_like; cd10225 632335003717 nucleotide binding site [chemical binding]; other site 632335003718 Mg binding site [ion binding]; other site 632335003719 putative protofilament interaction site [polypeptide binding]; other site 632335003720 RodZ interaction site [polypeptide binding]; other site 632335003721 rod shape-determining protein MreC; Provisional; Region: PRK13922 632335003722 rod shape-determining protein MreC; Region: MreC; pfam04085 632335003723 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 632335003724 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632335003725 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632335003726 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632335003727 septum formation inhibitor; Reviewed; Region: minC; PRK00513 632335003728 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 632335003729 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 632335003730 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 632335003731 P-loop; other site 632335003732 ADP binding residues [chemical binding]; other site 632335003733 Switch I; other site 632335003734 Switch II; other site 632335003735 Septum formation topological specificity factor MinE; Region: MinE; cl00538 632335003736 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 632335003737 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 632335003738 active site 632335003739 dimer interfaces [polypeptide binding]; other site 632335003740 catalytic residues [active] 632335003741 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 632335003742 Thiamine pyrophosphokinase; Region: TPK; cl08415 632335003743 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 632335003744 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 632335003745 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632335003746 active site 632335003747 spermidine synthase; Provisional; Region: PRK00811 632335003748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335003749 agmatinase; Region: agmatinase; TIGR01230 632335003750 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 632335003751 putative active site [active] 632335003752 Mn binding site [ion binding]; other site 632335003753 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335003754 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335003755 Integrase core domain; Region: rve; pfam00665 632335003756 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 632335003757 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632335003758 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632335003759 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 632335003760 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632335003761 carboxyltransferase (CT) interaction site; other site 632335003762 biotinylation site [posttranslational modification]; other site 632335003763 oxaloacetate decarboxylase; Provisional; Region: PRK12331 632335003764 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 632335003765 active site 632335003766 catalytic residues [active] 632335003767 metal binding site [ion binding]; metal-binding site 632335003768 homodimer binding site [polypeptide binding]; other site 632335003769 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 632335003770 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335003771 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335003772 Integrase core domain; Region: rve; pfam00665 632335003773 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632335003774 catalytic core [active] 632335003775 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 632335003776 hexamer interface [polypeptide binding]; other site 632335003777 RNA binding site [nucleotide binding]; other site 632335003778 Histidine-zinc binding site [chemical binding]; other site 632335003779 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 632335003780 homotrimer interaction site [polypeptide binding]; other site 632335003781 active site 632335003782 cytidylate kinase; Provisional; Region: cmk; PRK00023 632335003783 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 632335003784 CMP-binding site; other site 632335003785 The sites determining sugar specificity; other site 632335003786 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632335003787 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632335003788 putative acyl-acceptor binding pocket; other site 632335003789 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 632335003790 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 632335003791 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 632335003792 RNA binding site [nucleotide binding]; other site 632335003793 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632335003794 RNA binding site [nucleotide binding]; other site 632335003795 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 632335003796 RNA binding site [nucleotide binding]; other site 632335003797 PRC-barrel domain; Region: PRC; pfam05239 632335003798 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 632335003799 Domain of unknown function DUF20; Region: UPF0118; pfam01594 632335003800 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 632335003801 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 632335003802 motif 1; other site 632335003803 active site 632335003804 motif 2; other site 632335003805 motif 3; other site 632335003806 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 632335003807 DHHA1 domain; Region: DHHA1; pfam02272 632335003808 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 632335003809 nucleotide binding site/active site [active] 632335003810 HIT family signature motif; other site 632335003811 catalytic residue [active] 632335003812 ATP-NAD kinase; Region: NAD_kinase; pfam01513 632335003813 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 632335003814 arginine repressor; Provisional; Region: argR; PRK00441 632335003815 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 632335003816 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 632335003817 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 632335003818 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 632335003819 Walker A/P-loop; other site 632335003820 ATP binding site [chemical binding]; other site 632335003821 Q-loop/lid; other site 632335003822 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 632335003823 ABC transporter signature motif; other site 632335003824 Walker B; other site 632335003825 D-loop; other site 632335003826 H-loop/switch region; other site 632335003827 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 632335003828 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 632335003829 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 632335003830 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 632335003831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335003832 active site 632335003833 phosphorylation site [posttranslational modification] 632335003834 intermolecular recognition site; other site 632335003835 dimerization interface [polypeptide binding]; other site 632335003836 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 632335003837 stage V sporulation protein B; Region: spore_V_B; TIGR02900 632335003838 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 632335003839 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 632335003840 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 632335003841 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 632335003842 RNA/DNA hybrid binding site [nucleotide binding]; other site 632335003843 active site 632335003844 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 632335003845 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 632335003846 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 632335003847 dimer interface [polypeptide binding]; other site 632335003848 ADP-ribose binding site [chemical binding]; other site 632335003849 active site 632335003850 nudix motif; other site 632335003851 metal binding site [ion binding]; metal-binding site 632335003852 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 632335003853 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632335003854 active site 632335003855 PHP-associated; Region: PHP_C; pfam13263 632335003856 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 632335003857 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632335003858 catalytic residue [active] 632335003859 Protein of unknown function (DUF552); Region: DUF552; pfam04472 632335003860 YGGT family; Region: YGGT; pfam02325 632335003861 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 632335003862 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 632335003863 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632335003864 RNA binding surface [nucleotide binding]; other site 632335003865 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632335003866 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335003867 DivIVA protein; Region: DivIVA; pfam05103 632335003868 DivIVA domain; Region: DivI1A_domain; TIGR03544 632335003869 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 632335003870 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 632335003871 HIGH motif; other site 632335003872 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632335003873 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 632335003874 active site 632335003875 KMSKS motif; other site 632335003876 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 632335003877 tRNA binding surface [nucleotide binding]; other site 632335003878 anticodon binding site; other site 632335003879 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 632335003880 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 632335003881 active site 632335003882 dimer interface [polypeptide binding]; other site 632335003883 metal binding site [ion binding]; metal-binding site 632335003884 VanZ like family; Region: VanZ; cl01971 632335003885 Penicillinase repressor; Region: Pencillinase_R; cl17580 632335003886 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 632335003887 SnoaL-like domain; Region: SnoaL_4; pfam13577 632335003888 Putative amidase domain; Region: Amidase_6; pfam12671 632335003889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632335003890 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632335003891 Walker A/P-loop; other site 632335003892 ATP binding site [chemical binding]; other site 632335003893 Q-loop/lid; other site 632335003894 ABC transporter signature motif; other site 632335003895 Walker B; other site 632335003896 D-loop; other site 632335003897 H-loop/switch region; other site 632335003898 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 632335003899 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 632335003900 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 632335003901 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 632335003902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335003903 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335003904 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335003905 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632335003906 metal ion-dependent adhesion site (MIDAS); other site 632335003907 lipoprotein signal peptidase; Provisional; Region: PRK14787 632335003908 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 632335003909 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632335003910 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632335003911 RNA binding surface [nucleotide binding]; other site 632335003912 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 632335003913 active site 632335003914 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 632335003915 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632335003916 active site 632335003917 uracil transporter; Provisional; Region: PRK10720 632335003918 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 632335003919 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 632335003920 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 632335003921 dihydroorotase; Validated; Region: pyrC; PRK09357 632335003922 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632335003923 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 632335003924 active site 632335003925 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 632335003926 active site 632335003927 dimer interface [polypeptide binding]; other site 632335003928 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 632335003929 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632335003930 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 632335003931 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 632335003932 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632335003933 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632335003934 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 632335003935 IMP binding site; other site 632335003936 dimer interface [polypeptide binding]; other site 632335003937 interdomain contacts; other site 632335003938 partial ornithine binding site; other site 632335003939 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 632335003940 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 632335003941 FAD binding pocket [chemical binding]; other site 632335003942 FAD binding motif [chemical binding]; other site 632335003943 phosphate binding motif [ion binding]; other site 632335003944 beta-alpha-beta structure motif; other site 632335003945 NAD binding pocket [chemical binding]; other site 632335003946 Iron coordination center [ion binding]; other site 632335003947 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 632335003948 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 632335003949 heterodimer interface [polypeptide binding]; other site 632335003950 active site 632335003951 FMN binding site [chemical binding]; other site 632335003952 homodimer interface [polypeptide binding]; other site 632335003953 substrate binding site [chemical binding]; other site 632335003954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632335003955 catalytic core [active] 632335003956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632335003957 active site 632335003958 Double zinc ribbon; Region: DZR; pfam12773 632335003959 Adenylate kinase, active site lid; Region: ADK_lid; pfam05191 632335003960 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 632335003961 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 632335003962 Walker A/P-loop; other site 632335003963 ATP binding site [chemical binding]; other site 632335003964 Q-loop/lid; other site 632335003965 ABC transporter signature motif; other site 632335003966 Walker B; other site 632335003967 D-loop; other site 632335003968 H-loop/switch region; other site 632335003969 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 632335003970 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 632335003971 Walker A/P-loop; other site 632335003972 ATP binding site [chemical binding]; other site 632335003973 Q-loop/lid; other site 632335003974 ABC transporter signature motif; other site 632335003975 Walker B; other site 632335003976 D-loop; other site 632335003977 H-loop/switch region; other site 632335003978 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 632335003979 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 632335003980 TM-ABC transporter signature motif; other site 632335003981 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632335003982 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 632335003983 TM-ABC transporter signature motif; other site 632335003984 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 632335003985 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 632335003986 putative ligand binding site [chemical binding]; other site 632335003987 Uncharacterized conserved protein [Function unknown]; Region: COG1751 632335003988 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 632335003989 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632335003990 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632335003991 active site 632335003992 DNA binding site [nucleotide binding] 632335003993 Int/Topo IB signature motif; other site 632335003994 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632335003995 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 632335003996 putative active site [active] 632335003997 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 632335003998 Glucuronate isomerase; Region: UxaC; pfam02614 632335003999 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 632335004000 enolase; Provisional; Region: eno; PRK00077 632335004001 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 632335004002 dimer interface [polypeptide binding]; other site 632335004003 metal binding site [ion binding]; metal-binding site 632335004004 substrate binding pocket [chemical binding]; other site 632335004005 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 632335004006 phosphoglyceromutase; Provisional; Region: PRK05434 632335004007 bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962 632335004008 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 632335004009 substrate binding site [chemical binding]; other site 632335004010 hinge regions; other site 632335004011 ADP binding site [chemical binding]; other site 632335004012 catalytic site [active] 632335004013 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 632335004014 substrate binding site [chemical binding]; other site 632335004015 dimer interface [polypeptide binding]; other site 632335004016 catalytic triad [active] 632335004017 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 632335004018 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 632335004019 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 632335004020 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 632335004021 Predicted transcriptional regulator [Transcription]; Region: COG3388 632335004022 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 632335004023 pyruvate phosphate dikinase; Provisional; Region: PRK09279 632335004024 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 632335004025 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632335004026 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 632335004027 glycyl-tRNA synthetase; Provisional; Region: PRK04173 632335004028 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 632335004029 dimer interface [polypeptide binding]; other site 632335004030 motif 1; other site 632335004031 active site 632335004032 motif 2; other site 632335004033 motif 3; other site 632335004034 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 632335004035 anticodon binding site; other site 632335004036 Recombination protein O N terminal; Region: RecO_N; pfam11967 632335004037 DNA repair protein RecO; Region: reco; TIGR00613 632335004038 Recombination protein O C terminal; Region: RecO_C; pfam02565 632335004039 GTPase Era; Reviewed; Region: era; PRK00089 632335004040 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 632335004041 G1 box; other site 632335004042 GTP/Mg2+ binding site [chemical binding]; other site 632335004043 Switch I region; other site 632335004044 G2 box; other site 632335004045 Switch II region; other site 632335004046 G3 box; other site 632335004047 G4 box; other site 632335004048 G5 box; other site 632335004049 KH domain; Region: KH_2; pfam07650 632335004050 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632335004051 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 632335004052 active site 632335004053 hypothetical protein; Validated; Region: PRK07682 632335004054 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632335004055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335004056 homodimer interface [polypeptide binding]; other site 632335004057 catalytic residue [active] 632335004058 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632335004059 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632335004060 AsnC family; Region: AsnC_trans_reg; pfam01037 632335004061 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 632335004062 trimer interface [polypeptide binding]; other site 632335004063 active site 632335004064 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 632335004065 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 632335004066 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632335004067 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 632335004068 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632335004069 HSP70 interaction site [polypeptide binding]; other site 632335004070 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25); Region: Herpes_pp85; pfam04637 632335004071 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 632335004072 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 632335004073 gamma subunit interface [polypeptide binding]; other site 632335004074 epsilon subunit interface [polypeptide binding]; other site 632335004075 LBP interface [polypeptide binding]; other site 632335004076 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 632335004077 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 632335004078 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 632335004079 alpha subunit interaction interface [polypeptide binding]; other site 632335004080 Walker A motif; other site 632335004081 ATP binding site [chemical binding]; other site 632335004082 Walker B motif; other site 632335004083 inhibitor binding site; inhibition site 632335004084 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 632335004085 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 632335004086 core domain interface [polypeptide binding]; other site 632335004087 delta subunit interface [polypeptide binding]; other site 632335004088 epsilon subunit interface [polypeptide binding]; other site 632335004089 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 632335004090 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 632335004091 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 632335004092 beta subunit interaction interface [polypeptide binding]; other site 632335004093 Walker A motif; other site 632335004094 ATP binding site [chemical binding]; other site 632335004095 Walker B motif; other site 632335004096 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 632335004097 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 632335004098 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 632335004099 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 632335004100 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 632335004101 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 632335004102 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 632335004103 GMP synthase; Reviewed; Region: guaA; PRK00074 632335004104 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 632335004105 AMP/PPi binding site [chemical binding]; other site 632335004106 candidate oxyanion hole; other site 632335004107 catalytic triad [active] 632335004108 potential glutamine specificity residues [chemical binding]; other site 632335004109 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 632335004110 ATP Binding subdomain [chemical binding]; other site 632335004111 Ligand Binding sites [chemical binding]; other site 632335004112 Dimerization subdomain; other site 632335004113 Predicted permeases [General function prediction only]; Region: COG0679 632335004114 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 632335004115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632335004116 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 632335004117 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632335004118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632335004119 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 632335004120 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 632335004121 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 632335004122 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 632335004123 excinuclease ABC subunit B; Provisional; Region: PRK05298 632335004124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335004125 ATP binding site [chemical binding]; other site 632335004126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335004127 nucleotide binding region [chemical binding]; other site 632335004128 ATP-binding site [chemical binding]; other site 632335004129 Ultra-violet resistance protein B; Region: UvrB; pfam12344 632335004130 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 632335004131 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632335004132 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632335004133 catalytic residue [active] 632335004134 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 632335004135 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 632335004136 CoA-binding site [chemical binding]; other site 632335004137 ATP-binding [chemical binding]; other site 632335004138 DNA polymerase I; Provisional; Region: PRK05755 632335004139 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 632335004140 active site 632335004141 metal binding site 1 [ion binding]; metal-binding site 632335004142 putative 5' ssDNA interaction site; other site 632335004143 metal binding site 3; metal-binding site 632335004144 metal binding site 2 [ion binding]; metal-binding site 632335004145 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 632335004146 putative DNA binding site [nucleotide binding]; other site 632335004147 putative metal binding site [ion binding]; other site 632335004148 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 632335004149 active site 632335004150 substrate binding site [chemical binding]; other site 632335004151 catalytic site [active] 632335004152 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 632335004153 active site 632335004154 DNA binding site [nucleotide binding] 632335004155 catalytic site [active] 632335004156 Rubredoxin [Energy production and conversion]; Region: COG1773 632335004157 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 632335004158 iron binding site [ion binding]; other site 632335004159 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 632335004160 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 632335004161 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 632335004162 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 632335004163 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 632335004164 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 632335004165 purine monophosphate binding site [chemical binding]; other site 632335004166 dimer interface [polypeptide binding]; other site 632335004167 putative catalytic residues [active] 632335004168 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 632335004169 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 632335004170 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 632335004171 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 632335004172 active site 632335004173 substrate binding site [chemical binding]; other site 632335004174 cosubstrate binding site; other site 632335004175 catalytic site [active] 632335004176 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 632335004177 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 632335004178 dimerization interface [polypeptide binding]; other site 632335004179 putative ATP binding site [chemical binding]; other site 632335004180 amidophosphoribosyltransferase; Provisional; Region: PRK05793 632335004181 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 632335004182 active site 632335004183 tetramer interface [polypeptide binding]; other site 632335004184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632335004185 active site 632335004186 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 632335004187 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 632335004188 dimerization interface [polypeptide binding]; other site 632335004189 ATP binding site [chemical binding]; other site 632335004190 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 632335004191 dimerization interface [polypeptide binding]; other site 632335004192 ATP binding site [chemical binding]; other site 632335004193 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 632335004194 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 632335004195 putative active site [active] 632335004196 catalytic triad [active] 632335004197 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 632335004198 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 632335004199 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 632335004200 ATP binding site [chemical binding]; other site 632335004201 active site 632335004202 substrate binding site [chemical binding]; other site 632335004203 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 632335004204 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 632335004205 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632335004206 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632335004207 LrgA family; Region: LrgA; cl00608 632335004208 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632335004209 protein binding site [polypeptide binding]; other site 632335004210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632335004211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335004212 dimerization interface [polypeptide binding]; other site 632335004213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632335004214 dimer interface [polypeptide binding]; other site 632335004215 phosphorylation site [posttranslational modification] 632335004216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335004217 ATP binding site [chemical binding]; other site 632335004218 Mg2+ binding site [ion binding]; other site 632335004219 G-X-G motif; other site 632335004220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632335004221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335004222 active site 632335004223 phosphorylation site [posttranslational modification] 632335004224 intermolecular recognition site; other site 632335004225 dimerization interface [polypeptide binding]; other site 632335004226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632335004227 DNA binding site [nucleotide binding] 632335004228 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 632335004229 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 632335004230 dimerization interface [polypeptide binding]; other site 632335004231 putative ATP binding site [chemical binding]; other site 632335004232 Membrane protein of unknown function; Region: DUF360; pfam04020 632335004233 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 632335004234 single-stranded DNA-binding protein; Provisional; Region: PRK05813 632335004235 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632335004236 dimer interface [polypeptide binding]; other site 632335004237 ssDNA binding site [nucleotide binding]; other site 632335004238 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632335004239 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 632335004240 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 632335004241 NodB motif; other site 632335004242 active site 632335004243 catalytic site [active] 632335004244 metal binding site [ion binding]; metal-binding site 632335004245 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 632335004246 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 632335004247 putative ATP binding site [chemical binding]; other site 632335004248 putative substrate interface [chemical binding]; other site 632335004249 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 632335004250 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 632335004251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 632335004252 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 632335004253 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 632335004254 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632335004255 minor groove reading motif; other site 632335004256 helix-hairpin-helix signature motif; other site 632335004257 substrate binding pocket [chemical binding]; other site 632335004258 active site 632335004259 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 632335004260 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 632335004261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632335004262 Coenzyme A binding pocket [chemical binding]; other site 632335004263 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 632335004264 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 632335004265 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 632335004266 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 632335004267 Substrate binding site; other site 632335004268 Cupin domain; Region: Cupin_2; cl17218 632335004269 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 632335004270 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 632335004271 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 632335004272 metal binding site [ion binding]; metal-binding site 632335004273 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 632335004274 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 632335004275 substrate binding site [chemical binding]; other site 632335004276 glutamase interaction surface [polypeptide binding]; other site 632335004277 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 632335004278 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 632335004279 catalytic residues [active] 632335004280 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 632335004281 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 632335004282 putative active site [active] 632335004283 oxyanion strand; other site 632335004284 catalytic triad [active] 632335004285 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 632335004286 putative active site pocket [active] 632335004287 4-fold oligomerization interface [polypeptide binding]; other site 632335004288 metal binding residues [ion binding]; metal-binding site 632335004289 3-fold/trimer interface [polypeptide binding]; other site 632335004290 histidinol-phosphate aminotransferase; Provisional; Region: PRK03967 632335004291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632335004292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335004293 homodimer interface [polypeptide binding]; other site 632335004294 catalytic residue [active] 632335004295 histidinol dehydrogenase; Region: hisD; TIGR00069 632335004296 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 632335004297 NAD binding site [chemical binding]; other site 632335004298 dimerization interface [polypeptide binding]; other site 632335004299 product binding site; other site 632335004300 substrate binding site [chemical binding]; other site 632335004301 zinc binding site [ion binding]; other site 632335004302 catalytic residues [active] 632335004303 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 632335004304 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 632335004305 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 632335004306 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 632335004307 dimer interface [polypeptide binding]; other site 632335004308 motif 1; other site 632335004309 active site 632335004310 motif 2; other site 632335004311 motif 3; other site 632335004312 QueT transporter; Region: QueT; pfam06177 632335004313 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 632335004314 PhoU domain; Region: PhoU; pfam01895 632335004315 PhoU domain; Region: PhoU; pfam01895 632335004316 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 632335004317 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 632335004318 Walker A/P-loop; other site 632335004319 ATP binding site [chemical binding]; other site 632335004320 Q-loop/lid; other site 632335004321 ABC transporter signature motif; other site 632335004322 Walker B; other site 632335004323 D-loop; other site 632335004324 H-loop/switch region; other site 632335004325 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 632335004326 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 632335004327 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 632335004328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632335004329 dimer interface [polypeptide binding]; other site 632335004330 phosphorylation site [posttranslational modification] 632335004331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335004332 ATP binding site [chemical binding]; other site 632335004333 Mg2+ binding site [ion binding]; other site 632335004334 G-X-G motif; other site 632335004335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632335004336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335004337 active site 632335004338 phosphorylation site [posttranslational modification] 632335004339 intermolecular recognition site; other site 632335004340 dimerization interface [polypeptide binding]; other site 632335004341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632335004342 DNA binding site [nucleotide binding] 632335004343 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 632335004344 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 632335004345 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 632335004346 active site 632335004347 intersubunit interactions; other site 632335004348 catalytic residue [active] 632335004349 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 632335004350 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632335004351 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632335004352 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 632335004353 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 632335004354 HIGH motif; other site 632335004355 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632335004356 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 632335004357 active site 632335004358 KMSKS motif; other site 632335004359 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 632335004360 tRNA binding surface [nucleotide binding]; other site 632335004361 anticodon binding site; other site 632335004362 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 632335004363 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 632335004364 non-heme iron binding site [ion binding]; other site 632335004365 dimer interface [polypeptide binding]; other site 632335004366 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 632335004367 non-heme iron binding site [ion binding]; other site 632335004368 dimer interface [polypeptide binding]; other site 632335004369 propionate/acetate kinase; Provisional; Region: PRK12379 632335004370 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632335004371 nucleotide binding site [chemical binding]; other site 632335004372 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 632335004373 LexA repressor; Validated; Region: PRK00215 632335004374 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 632335004375 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632335004376 Catalytic site [active] 632335004377 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 632335004378 Aluminium resistance protein; Region: Alum_res; pfam06838 632335004379 bacterial Hfq-like; Region: Hfq; cd01716 632335004380 hexamer interface [polypeptide binding]; other site 632335004381 Sm1 motif; other site 632335004382 RNA binding site [nucleotide binding]; other site 632335004383 Sm2 motif; other site 632335004384 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 632335004385 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 632335004386 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 632335004387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335004388 ATP binding site [chemical binding]; other site 632335004389 Mg2+ binding site [ion binding]; other site 632335004390 G-X-G motif; other site 632335004391 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 632335004392 ATP binding site [chemical binding]; other site 632335004393 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 632335004394 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 632335004395 MutS domain I; Region: MutS_I; pfam01624 632335004396 MutS domain II; Region: MutS_II; pfam05188 632335004397 MutS domain III; Region: MutS_III; pfam05192 632335004398 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 632335004399 Walker A/P-loop; other site 632335004400 ATP binding site [chemical binding]; other site 632335004401 Q-loop/lid; other site 632335004402 ABC transporter signature motif; other site 632335004403 Walker B; other site 632335004404 D-loop; other site 632335004405 H-loop/switch region; other site 632335004406 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 632335004407 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632335004408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335004409 FeS/SAM binding site; other site 632335004410 TRAM domain; Region: TRAM; pfam01938 632335004411 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 632335004412 ACT domain-containing protein [General function prediction only]; Region: COG4747 632335004413 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 632335004414 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 632335004415 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632335004416 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632335004417 acyl-activating enzyme (AAE) consensus motif; other site 632335004418 AMP binding site [chemical binding]; other site 632335004419 active site 632335004420 CoA binding site [chemical binding]; other site 632335004421 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 632335004422 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 632335004423 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 632335004424 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632335004425 dimer interface [polypeptide binding]; other site 632335004426 PYR/PP interface [polypeptide binding]; other site 632335004427 TPP binding site [chemical binding]; other site 632335004428 substrate binding site [chemical binding]; other site 632335004429 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 632335004430 TPP-binding site; other site 632335004431 4Fe-4S binding domain; Region: Fer4; pfam00037 632335004432 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632335004433 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632335004434 acyl-activating enzyme (AAE) consensus motif; other site 632335004435 AMP binding site [chemical binding]; other site 632335004436 active site 632335004437 CoA binding site [chemical binding]; other site 632335004438 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 632335004439 Clp amino terminal domain; Region: Clp_N; pfam02861 632335004440 Clp amino terminal domain; Region: Clp_N; pfam02861 632335004441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335004442 Walker A motif; other site 632335004443 ATP binding site [chemical binding]; other site 632335004444 Walker B motif; other site 632335004445 arginine finger; other site 632335004446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335004447 Walker A motif; other site 632335004448 ATP binding site [chemical binding]; other site 632335004449 Walker B motif; other site 632335004450 arginine finger; other site 632335004451 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 632335004452 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 632335004453 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 632335004454 putative dimer interface [polypeptide binding]; other site 632335004455 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 632335004456 ATP cone domain; Region: ATP-cone; pfam03477 632335004457 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 632335004458 GAF domain; Region: GAF_3; pfam13492 632335004459 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632335004460 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632335004461 metal binding site [ion binding]; metal-binding site 632335004462 active site 632335004463 I-site; other site 632335004464 Transposase, Mutator family; Region: Transposase_mut; pfam00872 632335004465 MULE transposase domain; Region: MULE; pfam10551 632335004466 Uncharacterized conserved protein [Function unknown]; Region: COG1615 632335004467 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 632335004468 Protein of unknown function (DUF964); Region: DUF964; pfam06133 632335004469 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 632335004470 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 632335004471 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 632335004472 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 632335004473 DHH family; Region: DHH; pfam01368 632335004474 DHHA1 domain; Region: DHHA1; pfam02272 632335004475 degenerin; Region: deg-1; TIGR00867 632335004476 S-adenosylmethionine synthetase; Validated; Region: PRK05250 632335004477 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 632335004478 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 632335004479 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 632335004480 Transposase domain (DUF772); Region: DUF772; pfam05598 632335004481 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 632335004482 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 632335004483 putative active site [active] 632335004484 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 632335004485 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 632335004486 HAMP domain; Region: HAMP; pfam00672 632335004487 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632335004488 dimer interface [polypeptide binding]; other site 632335004489 putative CheW interface [polypeptide binding]; other site 632335004490 Uncharacterized conserved protein [Function unknown]; Region: COG0432 632335004491 Domain of unknown function (DUF377); Region: DUF377; pfam04041 632335004492 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 632335004493 active site 632335004494 KWG Leptospira; Region: KWG; pfam07656 632335004495 KWG Leptospira; Region: KWG; pfam07656 632335004496 KWG Leptospira; Region: KWG; pfam07656 632335004497 KWG Leptospira; Region: KWG; pfam07656 632335004498 KWG Leptospira; Region: KWG; pfam07656 632335004499 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 632335004500 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632335004501 PYR/PP interface [polypeptide binding]; other site 632335004502 dimer interface [polypeptide binding]; other site 632335004503 TPP binding site [chemical binding]; other site 632335004504 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632335004505 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 632335004506 TPP-binding site [chemical binding]; other site 632335004507 dimer interface [polypeptide binding]; other site 632335004508 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 632335004509 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 632335004510 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 632335004511 homodimer interface [polypeptide binding]; other site 632335004512 substrate-cofactor binding pocket; other site 632335004513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335004514 catalytic residue [active] 632335004515 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 632335004516 metal binding site [ion binding]; metal-binding site 632335004517 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 632335004518 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 632335004519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 632335004520 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 632335004521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 632335004522 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 632335004523 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 632335004524 dimer interface [polypeptide binding]; other site 632335004525 putative anticodon binding site; other site 632335004526 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 632335004527 motif 1; other site 632335004528 active site 632335004529 motif 2; other site 632335004530 motif 3; other site 632335004531 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 632335004532 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 632335004533 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 632335004534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335004535 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335004536 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335004537 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632335004538 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 632335004539 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632335004540 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 632335004541 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335004542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632335004543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632335004544 CHC2 zinc finger; Region: zf-CHC2; cl17510 632335004545 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 632335004546 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 632335004547 active site 632335004548 metal binding site [ion binding]; metal-binding site 632335004549 interdomain interaction site; other site 632335004550 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 632335004551 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632335004552 Walker A motif; other site 632335004553 ATP binding site [chemical binding]; other site 632335004554 Walker B motif; other site 632335004555 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632335004556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632335004557 non-specific DNA binding site [nucleotide binding]; other site 632335004558 salt bridge; other site 632335004559 sequence-specific DNA binding site [nucleotide binding]; other site 632335004560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632335004561 sequence-specific DNA binding site [nucleotide binding]; other site 632335004562 salt bridge; other site 632335004563 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632335004564 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632335004565 active site 632335004566 DNA binding site [nucleotide binding] 632335004567 Int/Topo IB signature motif; other site 632335004568 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 632335004569 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 632335004570 putative FMN binding site [chemical binding]; other site 632335004571 AAA domain; Region: AAA_32; pfam13654 632335004572 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 632335004573 RNA helicase; Region: RNA_helicase; pfam00910 632335004574 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 632335004575 Isopentenyl transferase; Region: IPT; pfam01745 632335004576 Asp23 family; Region: Asp23; cl00574 632335004577 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 632335004578 substrate binding site; other site 632335004579 dimer interface; other site 632335004580 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 632335004581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632335004582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632335004583 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632335004584 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632335004585 active site residue [active] 632335004586 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 632335004587 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 632335004588 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632335004589 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 632335004590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335004591 motif II; other site 632335004592 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 632335004593 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632335004594 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335004595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335004596 Walker A/P-loop; other site 632335004597 ATP binding site [chemical binding]; other site 632335004598 Q-loop/lid; other site 632335004599 ABC transporter signature motif; other site 632335004600 Walker B; other site 632335004601 D-loop; other site 632335004602 H-loop/switch region; other site 632335004603 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632335004604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335004605 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 632335004606 Walker A/P-loop; other site 632335004607 ATP binding site [chemical binding]; other site 632335004608 Q-loop/lid; other site 632335004609 ABC transporter signature motif; other site 632335004610 Walker B; other site 632335004611 D-loop; other site 632335004612 H-loop/switch region; other site 632335004613 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 632335004614 core dimer interface [polypeptide binding]; other site 632335004615 peripheral dimer interface [polypeptide binding]; other site 632335004616 L10 interface [polypeptide binding]; other site 632335004617 L11 interface [polypeptide binding]; other site 632335004618 putative EF-Tu interaction site [polypeptide binding]; other site 632335004619 putative EF-G interaction site [polypeptide binding]; other site 632335004620 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 632335004621 23S rRNA interface [nucleotide binding]; other site 632335004622 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 632335004623 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 632335004624 mRNA/rRNA interface [nucleotide binding]; other site 632335004625 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 632335004626 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 632335004627 23S rRNA interface [nucleotide binding]; other site 632335004628 L7/L12 interface [polypeptide binding]; other site 632335004629 putative thiostrepton binding site; other site 632335004630 L25 interface [polypeptide binding]; other site 632335004631 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 632335004632 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 632335004633 putative homodimer interface [polypeptide binding]; other site 632335004634 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 632335004635 heterodimer interface [polypeptide binding]; other site 632335004636 homodimer interface [polypeptide binding]; other site 632335004637 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 632335004638 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 632335004639 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 632335004640 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 632335004641 active site 632335004642 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632335004643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632335004644 DNA-binding site [nucleotide binding]; DNA binding site 632335004645 FCD domain; Region: FCD; pfam07729 632335004646 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 632335004647 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632335004648 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632335004649 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 632335004650 active site 632335004651 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 632335004652 dimer interface [polypeptide binding]; other site 632335004653 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 632335004654 Ligand Binding Site [chemical binding]; other site 632335004655 Molecular Tunnel; other site 632335004656 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 632335004657 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 632335004658 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 632335004659 catalytic site [active] 632335004660 subunit interface [polypeptide binding]; other site 632335004661 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 632335004662 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632335004663 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 632335004664 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 632335004665 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632335004666 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632335004667 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 632335004668 ornithine carbamoyltransferase; Provisional; Region: PRK00779 632335004669 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 632335004670 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 632335004671 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 632335004672 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 632335004673 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 632335004674 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632335004675 RNA binding surface [nucleotide binding]; other site 632335004676 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 632335004677 active site 632335004678 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 632335004679 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 632335004680 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 632335004681 Ligand Binding Site [chemical binding]; other site 632335004682 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 632335004683 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 632335004684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632335004685 catalytic residue [active] 632335004686 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 632335004687 RNA methyltransferase, RsmE family; Region: TIGR00046 632335004688 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 632335004689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335004690 S-adenosylmethionine binding site [chemical binding]; other site 632335004691 chaperone protein DnaJ; Provisional; Region: PRK14277 632335004692 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632335004693 HSP70 interaction site [polypeptide binding]; other site 632335004694 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 632335004695 substrate binding site [polypeptide binding]; other site 632335004696 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 632335004697 Zn binding sites [ion binding]; other site 632335004698 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 632335004699 dimer interface [polypeptide binding]; other site 632335004700 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 632335004701 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 632335004702 nucleotide binding site [chemical binding]; other site 632335004703 NEF interaction site [polypeptide binding]; other site 632335004704 SBD interface [polypeptide binding]; other site 632335004705 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 632335004706 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 632335004707 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 632335004708 dimer interface [polypeptide binding]; other site 632335004709 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 632335004710 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 632335004711 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 632335004712 clostripain; Region: clostrip; TIGR02806 632335004713 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 632335004714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335004715 FeS/SAM binding site; other site 632335004716 HemN C-terminal domain; Region: HemN_C; pfam06969 632335004717 GTP-binding protein LepA; Provisional; Region: PRK05433 632335004718 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 632335004719 G1 box; other site 632335004720 putative GEF interaction site [polypeptide binding]; other site 632335004721 GTP/Mg2+ binding site [chemical binding]; other site 632335004722 Switch I region; other site 632335004723 G2 box; other site 632335004724 G3 box; other site 632335004725 Switch II region; other site 632335004726 G4 box; other site 632335004727 G5 box; other site 632335004728 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 632335004729 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 632335004730 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 632335004731 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 632335004732 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 632335004733 putative active site [active] 632335004734 putative metal binding site [ion binding]; other site 632335004735 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632335004736 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 632335004737 active site 632335004738 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 632335004739 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335004740 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 632335004741 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 632335004742 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 632335004743 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 632335004744 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 632335004745 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 632335004746 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632335004747 metal binding site 2 [ion binding]; metal-binding site 632335004748 putative DNA binding helix; other site 632335004749 metal binding site 1 [ion binding]; metal-binding site 632335004750 dimer interface [polypeptide binding]; other site 632335004751 structural Zn2+ binding site [ion binding]; other site 632335004752 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 632335004753 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 632335004754 G1 box; other site 632335004755 GTP/Mg2+ binding site [chemical binding]; other site 632335004756 G2 box; other site 632335004757 Switch I region; other site 632335004758 G3 box; other site 632335004759 Switch II region; other site 632335004760 G4 box; other site 632335004761 G5 box; other site 632335004762 Nucleoside recognition; Region: Gate; pfam07670 632335004763 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 632335004764 Nucleoside recognition; Region: Gate; pfam07670 632335004765 FeoA domain; Region: FeoA; pfam04023 632335004766 Flavin Reductases; Region: FlaRed; cl00801 632335004767 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 632335004768 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 632335004769 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335004770 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335004771 DNA binding residues [nucleotide binding] 632335004772 Putative zinc-finger; Region: zf-HC2; pfam13490 632335004773 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632335004774 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335004775 Walker A/P-loop; other site 632335004776 ATP binding site [chemical binding]; other site 632335004777 Q-loop/lid; other site 632335004778 ABC transporter signature motif; other site 632335004779 Walker B; other site 632335004780 D-loop; other site 632335004781 H-loop/switch region; other site 632335004782 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 632335004783 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632335004784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632335004785 binding surface 632335004786 TPR motif; other site 632335004787 TPR repeat; Region: TPR_11; pfam13414 632335004788 TPR repeat; Region: TPR_11; pfam13414 632335004789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632335004790 TPR motif; other site 632335004791 binding surface 632335004792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335004793 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632335004794 Walker A motif; other site 632335004795 ATP binding site [chemical binding]; other site 632335004796 Walker B motif; other site 632335004797 arginine finger; other site 632335004798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632335004799 TPR motif; other site 632335004800 TPR repeat; Region: TPR_11; pfam13414 632335004801 binding surface 632335004802 TPR repeat; Region: TPR_11; pfam13414 632335004803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 632335004804 TPR motif; other site 632335004805 binding surface 632335004806 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 632335004807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335004808 Walker A motif; other site 632335004809 ATP binding site [chemical binding]; other site 632335004810 Walker B motif; other site 632335004811 arginine finger; other site 632335004812 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 632335004813 AAA ATPase domain; Region: AAA_15; pfam13175 632335004814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335004815 Walker A/P-loop; other site 632335004816 ATP binding site [chemical binding]; other site 632335004817 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 632335004818 putative active site [active] 632335004819 putative metal-binding site [ion binding]; other site 632335004820 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 632335004821 PLD-like domain; Region: PLDc_2; pfam13091 632335004822 putative active site [active] 632335004823 catalytic site [active] 632335004824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335004825 ATP binding site [chemical binding]; other site 632335004826 putative Mg++ binding site [ion binding]; other site 632335004827 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 632335004828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335004829 nucleotide binding region [chemical binding]; other site 632335004830 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 632335004831 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 632335004832 Protein of unknown function (DUF3780); Region: DUF3780; pfam12635 632335004833 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 632335004834 Protein of unknown function (DUF499); Region: DUF499; pfam04465 632335004835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335004836 AAA ATPase domain; Region: AAA_15; pfam13175 632335004837 Walker A/P-loop; other site 632335004838 ATP binding site [chemical binding]; other site 632335004839 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 632335004840 putative active site [active] 632335004841 putative metal-binding site [ion binding]; other site 632335004842 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 632335004843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335004844 ATP binding site [chemical binding]; other site 632335004845 putative Mg++ binding site [ion binding]; other site 632335004846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335004847 nucleotide binding region [chemical binding]; other site 632335004848 ATP-binding site [chemical binding]; other site 632335004849 Nuclease-related domain; Region: NERD; pfam08378 632335004850 Peptidase family M48; Region: Peptidase_M48; cl12018 632335004851 KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878 632335004852 KaiC; Region: KaiC; pfam06745 632335004853 Walker A motif; other site 632335004854 ATP binding site [chemical binding]; other site 632335004855 Walker B motif; other site 632335004856 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 632335004857 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 632335004858 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632335004859 dimer interface [polypeptide binding]; other site 632335004860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335004861 catalytic residue [active] 632335004862 Uncharacterized conserved protein [Function unknown]; Region: COG3937 632335004863 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632335004864 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335004865 ABC1 family; Region: ABC1; cl17513 632335004866 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 632335004867 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 632335004868 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 632335004869 nucleotide binding pocket [chemical binding]; other site 632335004870 K-X-D-G motif; other site 632335004871 catalytic site [active] 632335004872 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 632335004873 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 632335004874 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 632335004875 Dimer interface [polypeptide binding]; other site 632335004876 BRCT sequence motif; other site 632335004877 Uncharacterized conserved protein [Function unknown]; Region: COG0327 632335004878 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 632335004879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 632335004880 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 632335004881 Family of unknown function (DUF633); Region: DUF633; pfam04816 632335004882 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 632335004883 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335004884 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 632335004885 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632335004886 putative homodimer interface [polypeptide binding]; other site 632335004887 putative homotetramer interface [polypeptide binding]; other site 632335004888 putative allosteric switch controlling residues; other site 632335004889 putative metal binding site [ion binding]; other site 632335004890 putative homodimer-homodimer interface [polypeptide binding]; other site 632335004891 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 632335004892 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 632335004893 catalytic residues [active] 632335004894 Uncharacterized conserved protein [Function unknown]; Region: COG2968 632335004895 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 632335004896 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 632335004897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335004898 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632335004899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335004900 Predicted membrane protein [Function unknown]; Region: COG2510 632335004901 Heme NO binding; Region: HNOB; pfam07700 632335004902 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632335004903 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632335004904 dimer interface [polypeptide binding]; other site 632335004905 putative CheW interface [polypeptide binding]; other site 632335004906 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 632335004907 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 632335004908 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632335004909 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632335004910 catalytic residue [active] 632335004911 GTP-binding protein YchF; Reviewed; Region: PRK09601 632335004912 YchF GTPase; Region: YchF; cd01900 632335004913 G1 box; other site 632335004914 GTP/Mg2+ binding site [chemical binding]; other site 632335004915 Switch I region; other site 632335004916 G2 box; other site 632335004917 Switch II region; other site 632335004918 G3 box; other site 632335004919 G4 box; other site 632335004920 G5 box; other site 632335004921 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 632335004922 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 632335004923 AIR carboxylase; Region: AIRC; smart01001 632335004924 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 632335004925 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 632335004926 Ligand Binding Site [chemical binding]; other site 632335004927 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 632335004928 active site 632335004929 catalytic residues [active] 632335004930 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 632335004931 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632335004932 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 632335004933 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 632335004934 active site 632335004935 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 632335004936 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 632335004937 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 632335004938 Catalytic site [active] 632335004939 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 632335004940 MutS domain III; Region: MutS_III; pfam05192 632335004941 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 632335004942 Walker A/P-loop; other site 632335004943 ATP binding site [chemical binding]; other site 632335004944 Q-loop/lid; other site 632335004945 ABC transporter signature motif; other site 632335004946 Walker B; other site 632335004947 D-loop; other site 632335004948 H-loop/switch region; other site 632335004949 Smr domain; Region: Smr; pfam01713 632335004950 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632335004951 active site 632335004952 NTP binding site [chemical binding]; other site 632335004953 metal binding triad [ion binding]; metal-binding site 632335004954 antibiotic binding site [chemical binding]; other site 632335004955 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 632335004956 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 632335004957 putative catalytic cysteine [active] 632335004958 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 632335004959 gamma-glutamyl kinase; Provisional; Region: PRK05429 632335004960 nucleotide binding site [chemical binding]; other site 632335004961 homotetrameric interface [polypeptide binding]; other site 632335004962 putative phosphate binding site [ion binding]; other site 632335004963 putative allosteric binding site; other site 632335004964 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 632335004965 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 632335004966 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 632335004967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632335004968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335004969 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 632335004970 FlgN protein; Region: FlgN; pfam05130 632335004971 Flagellar protein FliS; Region: FliS; cl00654 632335004972 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632335004973 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335004974 flagellar capping protein; Validated; Region: fliD; PRK07737 632335004975 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 632335004976 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 632335004977 FlaG protein; Region: FlaG; pfam03646 632335004978 Protein of unknown function, DUF488; Region: DUF488; pfam04343 632335004979 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 632335004980 SecA binding site; other site 632335004981 Preprotein binding site; other site 632335004982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632335004983 binding surface 632335004984 TPR motif; other site 632335004985 TPR repeat; Region: TPR_11; pfam13414 632335004986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335004987 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632335004988 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632335004989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335004990 S-adenosylmethionine binding site [chemical binding]; other site 632335004991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 632335004992 active site 632335004993 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 632335004994 putative metal binding site; other site 632335004995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632335004996 binding surface 632335004997 TPR motif; other site 632335004998 TPR repeat; Region: TPR_11; pfam13414 632335004999 flagellin; Provisional; Region: PRK12804 632335005000 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 632335005001 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 632335005002 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335005003 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335005004 Integrase core domain; Region: rve; pfam00665 632335005005 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632335005006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335005007 ATP binding site [chemical binding]; other site 632335005008 putative Mg++ binding site [ion binding]; other site 632335005009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335005010 nucleotide binding region [chemical binding]; other site 632335005011 ATP-binding site [chemical binding]; other site 632335005012 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632335005013 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632335005014 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632335005015 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632335005016 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632335005017 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 632335005018 Global regulator protein family; Region: CsrA; pfam02599 632335005019 flagellar assembly protein FliW; Provisional; Region: PRK13285 632335005020 Uncharacterized conserved protein [Function unknown]; Region: COG2445 632335005021 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 632335005022 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 632335005023 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 632335005024 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 632335005025 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 632335005026 FlgN protein; Region: FlgN; pfam05130 632335005027 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 632335005028 flagellar operon protein TIGR03826; Region: YvyF 632335005029 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 632335005030 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632335005031 active site 632335005032 sporulation sigma factor SigF; Validated; Region: PRK05572 632335005033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335005034 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632335005035 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335005036 DNA binding residues [nucleotide binding] 632335005037 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 632335005038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335005039 ATP binding site [chemical binding]; other site 632335005040 Mg2+ binding site [ion binding]; other site 632335005041 G-X-G motif; other site 632335005042 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632335005043 anti sigma factor interaction site; other site 632335005044 regulatory phosphorylation site [posttranslational modification]; other site 632335005045 Uncharacterized conserved protein [Function unknown]; Region: COG1434 632335005046 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 632335005047 putative active site [active] 632335005048 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 632335005049 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 632335005050 dimerization interface 3.5A [polypeptide binding]; other site 632335005051 active site 632335005052 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 632335005053 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 632335005054 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632335005055 Walker A/P-loop; other site 632335005056 ATP binding site [chemical binding]; other site 632335005057 Q-loop/lid; other site 632335005058 ABC transporter signature motif; other site 632335005059 Walker B; other site 632335005060 D-loop; other site 632335005061 H-loop/switch region; other site 632335005062 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 632335005063 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632335005064 Walker A/P-loop; other site 632335005065 ATP binding site [chemical binding]; other site 632335005066 Q-loop/lid; other site 632335005067 ABC transporter signature motif; other site 632335005068 Walker B; other site 632335005069 D-loop; other site 632335005070 H-loop/switch region; other site 632335005071 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 632335005072 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 632335005073 substrate binding site [chemical binding]; other site 632335005074 active site 632335005075 catalytic residues [active] 632335005076 heterodimer interface [polypeptide binding]; other site 632335005077 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 632335005078 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 632335005079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335005080 catalytic residue [active] 632335005081 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 632335005082 active site 632335005083 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 632335005084 active site 632335005085 ribulose/triose binding site [chemical binding]; other site 632335005086 phosphate binding site [ion binding]; other site 632335005087 substrate (anthranilate) binding pocket [chemical binding]; other site 632335005088 product (indole) binding pocket [chemical binding]; other site 632335005089 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 632335005090 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 632335005091 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 632335005092 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 632335005093 Glutamine amidotransferase class-I; Region: GATase; pfam00117 632335005094 glutamine binding [chemical binding]; other site 632335005095 catalytic triad [active] 632335005096 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 632335005097 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 632335005098 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 632335005099 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 632335005100 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 632335005101 active site 632335005102 Dehydroquinase class II; Region: DHquinase_II; pfam01220 632335005103 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 632335005104 trimer interface [polypeptide binding]; other site 632335005105 active site 632335005106 dimer interface [polypeptide binding]; other site 632335005107 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 632335005108 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632335005109 Metal-binding active site; metal-binding site 632335005110 AP (apurinic/apyrimidinic) site pocket; other site 632335005111 shikimate kinase; Reviewed; Region: aroK; PRK00131 632335005112 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 632335005113 ADP binding site [chemical binding]; other site 632335005114 magnesium binding site [ion binding]; other site 632335005115 putative shikimate binding site; other site 632335005116 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 632335005117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335005118 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335005119 DNA binding residues [nucleotide binding] 632335005120 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 632335005121 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632335005122 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335005123 Walker A/P-loop; other site 632335005124 ATP binding site [chemical binding]; other site 632335005125 Q-loop/lid; other site 632335005126 ABC transporter signature motif; other site 632335005127 Walker B; other site 632335005128 D-loop; other site 632335005129 H-loop/switch region; other site 632335005130 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 632335005131 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 632335005132 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632335005133 dimer interface [polypeptide binding]; other site 632335005134 PYR/PP interface [polypeptide binding]; other site 632335005135 TPP binding site [chemical binding]; other site 632335005136 substrate binding site [chemical binding]; other site 632335005137 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632335005138 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 632335005139 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 632335005140 TPP-binding site [chemical binding]; other site 632335005141 putative dimer interface [polypeptide binding]; other site 632335005142 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 632335005143 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 632335005144 4Fe-4S binding domain; Region: Fer4_6; pfam12837 632335005145 4Fe-4S binding domain; Region: Fer4; pfam00037 632335005146 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 632335005147 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 632335005148 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 632335005149 active site 632335005150 NTP binding site [chemical binding]; other site 632335005151 metal binding triad [ion binding]; metal-binding site 632335005152 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 632335005153 histidinol-phosphatase; Provisional; Region: PRK05588 632335005154 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632335005155 active site 632335005156 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 632335005157 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 632335005158 Ligand Binding Site [chemical binding]; other site 632335005159 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 632335005160 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 632335005161 trimerization site [polypeptide binding]; other site 632335005162 active site 632335005163 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 632335005164 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 632335005165 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632335005166 catalytic residue [active] 632335005167 Transcriptional regulator; Region: Rrf2; cl17282 632335005168 Rrf2 family protein; Region: rrf2_super; TIGR00738 632335005169 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 632335005170 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 632335005171 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 632335005172 alphaNTD homodimer interface [polypeptide binding]; other site 632335005173 alphaNTD - beta interaction site [polypeptide binding]; other site 632335005174 alphaNTD - beta' interaction site [polypeptide binding]; other site 632335005175 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 632335005176 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 632335005177 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 632335005178 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632335005179 RNA binding surface [nucleotide binding]; other site 632335005180 30S ribosomal protein S11; Validated; Region: PRK05309 632335005181 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 632335005182 30S ribosomal protein S13; Region: bact_S13; TIGR03631 632335005183 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 632335005184 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 632335005185 rRNA binding site [nucleotide binding]; other site 632335005186 predicted 30S ribosome binding site; other site 632335005187 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 632335005188 RNA binding site [nucleotide binding]; other site 632335005189 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 632335005190 active site 632335005191 adenylate kinase; Reviewed; Region: adk; PRK00279 632335005192 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 632335005193 AMP-binding site [chemical binding]; other site 632335005194 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 632335005195 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 632335005196 SecY translocase; Region: SecY; pfam00344 632335005197 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 632335005198 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 632335005199 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 632335005200 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 632335005201 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 632335005202 23S rRNA interface [nucleotide binding]; other site 632335005203 5S rRNA interface [nucleotide binding]; other site 632335005204 L27 interface [polypeptide binding]; other site 632335005205 L5 interface [polypeptide binding]; other site 632335005206 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 632335005207 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 632335005208 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 632335005209 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 632335005210 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 632335005211 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 632335005212 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 632335005213 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 632335005214 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 632335005215 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 632335005216 RNA binding site [nucleotide binding]; other site 632335005217 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 632335005218 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 632335005219 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 632335005220 23S rRNA interface [nucleotide binding]; other site 632335005221 putative translocon interaction site; other site 632335005222 signal recognition particle (SRP54) interaction site; other site 632335005223 L23 interface [polypeptide binding]; other site 632335005224 trigger factor interaction site; other site 632335005225 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 632335005226 23S rRNA interface [nucleotide binding]; other site 632335005227 5S rRNA interface [nucleotide binding]; other site 632335005228 putative antibiotic binding site [chemical binding]; other site 632335005229 L25 interface [polypeptide binding]; other site 632335005230 L27 interface [polypeptide binding]; other site 632335005231 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 632335005232 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 632335005233 G-X-X-G motif; other site 632335005234 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 632335005235 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 632335005236 putative translocon binding site; other site 632335005237 protein-rRNA interface [nucleotide binding]; other site 632335005238 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 632335005239 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 632335005240 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 632335005241 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 632335005242 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 632335005243 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 632335005244 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 632335005245 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 632335005246 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 632335005247 iron binding site [ion binding]; other site 632335005248 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 632335005249 Ferritin-like domain; Region: Ferritin; pfam00210 632335005250 dinuclear metal binding motif [ion binding]; other site 632335005251 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335005252 Zn2+ binding site [ion binding]; other site 632335005253 Mg2+ binding site [ion binding]; other site 632335005254 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632335005255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335005256 Zn2+ binding site [ion binding]; other site 632335005257 Mg2+ binding site [ion binding]; other site 632335005258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632335005259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335005260 dimerization interface [polypeptide binding]; other site 632335005261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632335005262 dimer interface [polypeptide binding]; other site 632335005263 phosphorylation site [posttranslational modification] 632335005264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335005265 ATP binding site [chemical binding]; other site 632335005266 Mg2+ binding site [ion binding]; other site 632335005267 G-X-G motif; other site 632335005268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632335005269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335005270 active site 632335005271 phosphorylation site [posttranslational modification] 632335005272 intermolecular recognition site; other site 632335005273 dimerization interface [polypeptide binding]; other site 632335005274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632335005275 DNA binding site [nucleotide binding] 632335005276 RRXRR protein; Region: RRXRR; pfam14239 632335005277 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632335005278 active site 632335005279 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 632335005280 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 632335005281 active site 632335005282 substrate binding site [chemical binding]; other site 632335005283 metal binding site [ion binding]; metal-binding site 632335005284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335005285 H+ Antiporter protein; Region: 2A0121; TIGR00900 632335005286 putative substrate translocation pore; other site 632335005287 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 632335005288 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 632335005289 oligomer interface [polypeptide binding]; other site 632335005290 putative active site [active] 632335005291 metal binding site [ion binding]; metal-binding site 632335005292 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 632335005293 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 632335005294 B12 binding domain; Region: B12-binding; pfam02310 632335005295 B12 binding site [chemical binding]; other site 632335005296 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 632335005297 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335005298 FeS/SAM binding site; other site 632335005299 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 632335005300 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 632335005301 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 632335005302 CPxP motif; other site 632335005303 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632335005304 putative homodimer interface [polypeptide binding]; other site 632335005305 putative homotetramer interface [polypeptide binding]; other site 632335005306 putative allosteric switch controlling residues; other site 632335005307 putative metal binding site [ion binding]; other site 632335005308 putative homodimer-homodimer interface [polypeptide binding]; other site 632335005309 4Fe-4S binding domain; Region: Fer4; cl02805 632335005310 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 632335005311 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632335005312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632335005313 DNA-binding site [nucleotide binding]; DNA binding site 632335005314 FCD domain; Region: FCD; pfam07729 632335005315 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 632335005316 isocitrate dehydrogenase; Validated; Region: PRK06451 632335005317 aconitate hydratase; Validated; Region: PRK07229 632335005318 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 632335005319 substrate binding site [chemical binding]; other site 632335005320 ligand binding site [chemical binding]; other site 632335005321 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 632335005322 substrate binding site [chemical binding]; other site 632335005323 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 632335005324 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 632335005325 putative ligand binding site [chemical binding]; other site 632335005326 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 632335005327 active site 632335005328 catalytic residues [active] 632335005329 metal binding site [ion binding]; metal-binding site 632335005330 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 632335005331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335005332 dimer interface [polypeptide binding]; other site 632335005333 conserved gate region; other site 632335005334 putative PBP binding loops; other site 632335005335 ABC-ATPase subunit interface; other site 632335005336 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632335005337 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 632335005338 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 632335005339 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632335005340 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967 632335005341 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 632335005342 Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia. This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965 632335005343 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 632335005344 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 632335005345 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967 632335005346 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 632335005347 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632335005348 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 632335005349 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632335005350 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 632335005351 nitrogenase iron protein; Region: nifH; TIGR01287 632335005352 Nucleotide-binding sites [chemical binding]; other site 632335005353 Walker A motif; other site 632335005354 Switch I region of nucleotide binding site; other site 632335005355 Fe4S4 binding sites [ion binding]; other site 632335005356 Switch II region of nucleotide binding site; other site 632335005357 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 632335005358 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632335005359 ammonium transporter; Region: amt; TIGR00836 632335005360 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 632335005361 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 632335005362 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 632335005363 active site 632335005364 catalytic residues [active] 632335005365 metal binding site [ion binding]; metal-binding site 632335005366 RmuC family; Region: RmuC; pfam02646 632335005367 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 632335005368 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 632335005369 DNA polymerase III subunit delta'; Validated; Region: PRK08485 632335005370 Protein of unknown function (DUF327); Region: DUF327; pfam03885 632335005371 Protein of unknown function (DUF970); Region: DUF970; pfam06153 632335005372 thymidylate kinase; Validated; Region: tmk; PRK00698 632335005373 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 632335005374 TMP-binding site; other site 632335005375 ATP-binding site [chemical binding]; other site 632335005376 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 632335005377 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632335005378 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632335005379 catalytic residue [active] 632335005380 Fumarase C-terminus; Region: Fumerase_C; pfam05683 632335005381 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632335005382 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632335005383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632335005384 Probable transposase; Region: OrfB_IS605; pfam01385 632335005385 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335005386 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 632335005387 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 632335005388 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 632335005389 active site 632335005390 catalytic residues [active] 632335005391 metal binding site [ion binding]; metal-binding site 632335005392 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 632335005393 2-isopropylmalate synthase; Validated; Region: PRK00915 632335005394 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 632335005395 active site 632335005396 catalytic residues [active] 632335005397 metal binding site [ion binding]; metal-binding site 632335005398 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 632335005399 ketol-acid reductoisomerase; Provisional; Region: PRK05479 632335005400 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 632335005401 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 632335005402 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 632335005403 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 632335005404 putative valine binding site [chemical binding]; other site 632335005405 dimer interface [polypeptide binding]; other site 632335005406 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 632335005407 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 632335005408 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632335005409 PYR/PP interface [polypeptide binding]; other site 632335005410 dimer interface [polypeptide binding]; other site 632335005411 TPP binding site [chemical binding]; other site 632335005412 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632335005413 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 632335005414 TPP-binding site [chemical binding]; other site 632335005415 dimer interface [polypeptide binding]; other site 632335005416 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 632335005417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632335005418 NAD(P) binding site [chemical binding]; other site 632335005419 active site 632335005420 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 632335005421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 632335005422 active site 632335005423 H+ Antiporter protein; Region: 2A0121; TIGR00900 632335005424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335005425 putative substrate translocation pore; other site 632335005426 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335005427 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 632335005428 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 632335005429 active site 632335005430 Uncharacterized conserved protein [Function unknown]; Region: COG1633 632335005431 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 632335005432 diiron binding motif [ion binding]; other site 632335005433 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 632335005434 Aspartase; Region: Aspartase; cd01357 632335005435 active sites [active] 632335005436 tetramer interface [polypeptide binding]; other site 632335005437 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 632335005438 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 632335005439 G1 box; other site 632335005440 GTP/Mg2+ binding site [chemical binding]; other site 632335005441 Switch I region; other site 632335005442 G2 box; other site 632335005443 Switch II region; other site 632335005444 G3 box; other site 632335005445 G4 box; other site 632335005446 G5 box; other site 632335005447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 632335005448 Predicted acetyltransferase [General function prediction only]; Region: COG3393 632335005449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632335005450 Coenzyme A binding pocket [chemical binding]; other site 632335005451 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 632335005452 Melibiase; Region: Melibiase; pfam02065 632335005453 CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881 632335005454 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632335005455 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335005456 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 632335005457 Walker A/P-loop; other site 632335005458 ATP binding site [chemical binding]; other site 632335005459 Q-loop/lid; other site 632335005460 ABC transporter signature motif; other site 632335005461 Walker B; other site 632335005462 D-loop; other site 632335005463 H-loop/switch region; other site 632335005464 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 632335005465 Pectate lyase; Region: Pectate_lyase; pfam03211 632335005466 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 632335005467 Right handed beta helix region; Region: Beta_helix; pfam13229 632335005468 Helix-turn-helix domain; Region: HTH_18; pfam12833 632335005469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335005470 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335005471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335005472 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335005473 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 632335005474 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 632335005475 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 632335005476 mannonate dehydratase; Provisional; Region: PRK03906 632335005477 mannonate dehydratase; Region: uxuA; TIGR00695 632335005478 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 632335005479 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 632335005480 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 632335005481 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 632335005482 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 632335005483 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 632335005484 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632335005485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335005486 active site 632335005487 phosphorylation site [posttranslational modification] 632335005488 intermolecular recognition site; other site 632335005489 dimerization interface [polypeptide binding]; other site 632335005490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335005491 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 632335005492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335005493 dimerization interface [polypeptide binding]; other site 632335005494 Histidine kinase; Region: His_kinase; pfam06580 632335005495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335005496 ATP binding site [chemical binding]; other site 632335005497 Mg2+ binding site [ion binding]; other site 632335005498 G-X-G motif; other site 632335005499 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335005500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335005501 dimer interface [polypeptide binding]; other site 632335005502 ABC-ATPase subunit interface; other site 632335005503 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632335005504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335005505 dimer interface [polypeptide binding]; other site 632335005506 conserved gate region; other site 632335005507 ABC-ATPase subunit interface; other site 632335005508 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632335005509 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335005510 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 632335005511 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335005512 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335005513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335005514 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 632335005515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632335005516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335005517 homodimer interface [polypeptide binding]; other site 632335005518 catalytic residue [active] 632335005519 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 632335005520 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 632335005521 prephenate dehydrogenase; Validated; Region: PRK08507 632335005522 Prephenate dehydrogenase; Region: PDH; pfam02153 632335005523 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 632335005524 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 632335005525 hinge; other site 632335005526 active site 632335005527 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632335005528 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 632335005529 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632335005530 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 632335005531 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 632335005532 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 632335005533 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632335005534 active site 632335005535 metal binding site [ion binding]; metal-binding site 632335005536 homotetramer interface [polypeptide binding]; other site 632335005537 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 632335005538 active site 632335005539 dimerization interface [polypeptide binding]; other site 632335005540 ribonuclease PH; Reviewed; Region: rph; PRK00173 632335005541 Ribonuclease PH; Region: RNase_PH_bact; cd11362 632335005542 hexamer interface [polypeptide binding]; other site 632335005543 active site 632335005544 Sporulation and spore germination; Region: Germane; smart00909 632335005545 Sporulation and spore germination; Region: Germane; cl11253 632335005546 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 632335005547 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 632335005548 Mg++ binding site [ion binding]; other site 632335005549 putative catalytic motif [active] 632335005550 substrate binding site [chemical binding]; other site 632335005551 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 632335005552 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 632335005553 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 632335005554 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 632335005555 Coenzyme A binding pocket [chemical binding]; other site 632335005556 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 632335005557 MPT binding site; other site 632335005558 trimer interface [polypeptide binding]; other site 632335005559 molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499 632335005560 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 632335005561 trimer interface [polypeptide binding]; other site 632335005562 dimer interface [polypeptide binding]; other site 632335005563 putative active site [active] 632335005564 MOSC domain; Region: MOSC; pfam03473 632335005565 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 632335005566 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335005567 FeS/SAM binding site; other site 632335005568 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 632335005569 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 632335005570 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 632335005571 dimer interface [polypeptide binding]; other site 632335005572 putative functional site; other site 632335005573 putative MPT binding site; other site 632335005574 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 632335005575 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 632335005576 dimer interface [polypeptide binding]; other site 632335005577 putative functional site; other site 632335005578 putative MPT binding site; other site 632335005579 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632335005580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335005581 Walker A/P-loop; other site 632335005582 ATP binding site [chemical binding]; other site 632335005583 Q-loop/lid; other site 632335005584 ABC transporter signature motif; other site 632335005585 Walker B; other site 632335005586 D-loop; other site 632335005587 H-loop/switch region; other site 632335005588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335005589 dimer interface [polypeptide binding]; other site 632335005590 conserved gate region; other site 632335005591 putative PBP binding loops; other site 632335005592 ABC-ATPase subunit interface; other site 632335005593 PBP superfamily domain; Region: PBP_like_2; pfam12849 632335005594 hypothetical protein; Provisional; Region: PRK08328 632335005595 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 632335005596 ATP binding site [chemical binding]; other site 632335005597 substrate interface [chemical binding]; other site 632335005598 ThiS family; Region: ThiS; pfam02597 632335005599 charged pocket; other site 632335005600 hydrophobic patch; other site 632335005601 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 632335005602 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 632335005603 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 632335005604 NADH dehydrogenase subunit I; Region: ndhI; CHL00014 632335005605 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 632335005606 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 632335005607 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632335005608 hypothetical protein; Validated; Region: PRK00110 632335005609 stage V sporulation protein B; Region: spore_V_B; TIGR02900 632335005610 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 632335005611 Uncharacterized conserved protein [Function unknown]; Region: COG1739 632335005612 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 632335005613 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 632335005614 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 632335005615 active site 632335005616 Ap6A binding site [chemical binding]; other site 632335005617 nudix motif; other site 632335005618 metal binding site [ion binding]; metal-binding site 632335005619 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 632335005620 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 632335005621 HflX GTPase family; Region: HflX; cd01878 632335005622 G1 box; other site 632335005623 GTP/Mg2+ binding site [chemical binding]; other site 632335005624 Switch I region; other site 632335005625 G2 box; other site 632335005626 G3 box; other site 632335005627 Switch II region; other site 632335005628 G4 box; other site 632335005629 G5 box; other site 632335005630 elongation factor Tu; Reviewed; Region: PRK00049 632335005631 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 632335005632 G1 box; other site 632335005633 GEF interaction site [polypeptide binding]; other site 632335005634 GTP/Mg2+ binding site [chemical binding]; other site 632335005635 Switch I region; other site 632335005636 G2 box; other site 632335005637 G3 box; other site 632335005638 Switch II region; other site 632335005639 G4 box; other site 632335005640 G5 box; other site 632335005641 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 632335005642 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 632335005643 Antibiotic Binding Site [chemical binding]; other site 632335005644 elongation factor G; Reviewed; Region: PRK00007 632335005645 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 632335005646 G1 box; other site 632335005647 putative GEF interaction site [polypeptide binding]; other site 632335005648 GTP/Mg2+ binding site [chemical binding]; other site 632335005649 Switch I region; other site 632335005650 G2 box; other site 632335005651 G3 box; other site 632335005652 Switch II region; other site 632335005653 G4 box; other site 632335005654 G5 box; other site 632335005655 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 632335005656 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 632335005657 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 632335005658 30S ribosomal protein S7; Validated; Region: PRK05302 632335005659 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 632335005660 S17 interaction site [polypeptide binding]; other site 632335005661 S8 interaction site; other site 632335005662 16S rRNA interaction site [nucleotide binding]; other site 632335005663 streptomycin interaction site [chemical binding]; other site 632335005664 23S rRNA interaction site [nucleotide binding]; other site 632335005665 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 632335005666 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 632335005667 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 632335005668 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 632335005669 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 632335005670 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 632335005671 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 632335005672 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 632335005673 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 632335005674 G-loop; other site 632335005675 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 632335005676 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 632335005677 DNA binding site [nucleotide binding] 632335005678 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 632335005679 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 632335005680 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 632335005681 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 632335005682 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 632335005683 RPB1 interaction site [polypeptide binding]; other site 632335005684 RPB10 interaction site [polypeptide binding]; other site 632335005685 RPB11 interaction site [polypeptide binding]; other site 632335005686 RPB3 interaction site [polypeptide binding]; other site 632335005687 RPB12 interaction site [polypeptide binding]; other site 632335005688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632335005689 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632335005690 Integrase core domain; Region: rve; pfam00665 632335005691 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 632335005692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335005693 active site 632335005694 phosphorylation site [posttranslational modification] 632335005695 intermolecular recognition site; other site 632335005696 dimerization interface [polypeptide binding]; other site 632335005697 CheB methylesterase; Region: CheB_methylest; pfam01339 632335005698 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 632335005699 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 632335005700 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 632335005701 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 632335005702 active site 632335005703 dimer interface [polypeptide binding]; other site 632335005704 motif 1; other site 632335005705 motif 2; other site 632335005706 motif 3; other site 632335005707 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 632335005708 anticodon binding site; other site 632335005709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632335005710 binding surface 632335005711 TPR repeat; Region: TPR_11; pfam13414 632335005712 TPR motif; other site 632335005713 Tetratricopeptide repeat; Region: TPR_16; pfam13432 632335005714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632335005715 binding surface 632335005716 TPR repeat; Region: TPR_11; pfam13414 632335005717 TPR motif; other site 632335005718 Divergent AAA domain; Region: AAA_4; pfam04326 632335005719 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 632335005720 CHASE4 domain; Region: CHASE4; cl01308 632335005721 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632335005722 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335005723 Zn2+ binding site [ion binding]; other site 632335005724 Mg2+ binding site [ion binding]; other site 632335005725 Peptidase family M23; Region: Peptidase_M23; pfam01551 632335005726 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 632335005727 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 632335005728 ScpA/B protein; Region: ScpA_ScpB; cl00598 632335005729 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 632335005730 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 632335005731 active site 632335005732 HIGH motif; other site 632335005733 dimer interface [polypeptide binding]; other site 632335005734 KMSKS motif; other site 632335005735 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 632335005736 Peptidase family M50; Region: Peptidase_M50; pfam02163 632335005737 active site 632335005738 putative substrate binding region [chemical binding]; other site 632335005739 diaminopimelate decarboxylase; Region: lysA; TIGR01048 632335005740 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 632335005741 active site 632335005742 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632335005743 substrate binding site [chemical binding]; other site 632335005744 catalytic residues [active] 632335005745 dimer interface [polypeptide binding]; other site 632335005746 AMP-binding domain protein; Validated; Region: PRK08315 632335005747 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632335005748 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 632335005749 acyl-activating enzyme (AAE) consensus motif; other site 632335005750 putative AMP binding site [chemical binding]; other site 632335005751 putative active site [active] 632335005752 putative CoA binding site [chemical binding]; other site 632335005753 sporulation sigma factor SigG; Reviewed; Region: PRK08215 632335005754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335005755 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632335005756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335005757 DNA binding residues [nucleotide binding] 632335005758 sporulation sigma factor SigE; Reviewed; Region: PRK08301 632335005759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335005760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335005761 DNA binding residues [nucleotide binding] 632335005762 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 632335005763 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 632335005764 Domain of unknown function (DUF303); Region: DUF303; pfam03629 632335005765 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 632335005766 Domain of unknown function (DUF303); Region: DUF303; pfam03629 632335005767 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 632335005768 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 632335005769 putative active site [active] 632335005770 putative metal binding site [ion binding]; other site 632335005771 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 632335005772 cell division protein FtsZ; Validated; Region: PRK09330 632335005773 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 632335005774 nucleotide binding site [chemical binding]; other site 632335005775 SulA interaction site; other site 632335005776 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 632335005777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 632335005778 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 632335005779 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 632335005780 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 632335005781 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632335005782 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632335005783 hinge; other site 632335005784 active site 632335005785 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 632335005786 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 632335005787 active site 632335005788 homodimer interface [polypeptide binding]; other site 632335005789 cell division protein FtsW; Region: ftsW; TIGR02614 632335005790 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 632335005791 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 632335005792 NAD binding site [chemical binding]; other site 632335005793 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632335005794 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632335005795 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 632335005796 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 632335005797 Mg++ binding site [ion binding]; other site 632335005798 putative catalytic motif [active] 632335005799 putative substrate binding site [chemical binding]; other site 632335005800 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 632335005801 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632335005802 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632335005803 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632335005804 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 632335005805 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632335005806 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632335005807 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632335005808 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 632335005809 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 632335005810 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632335005811 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632335005812 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 632335005813 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 632335005814 Cell division protein FtsL; Region: FtsL; cl11433 632335005815 MraW methylase family; Region: Methyltransf_5; pfam01795 632335005816 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 632335005817 cell division protein MraZ; Reviewed; Region: PRK00326 632335005818 MraZ protein; Region: MraZ; pfam02381 632335005819 MraZ protein; Region: MraZ; pfam02381 632335005820 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 632335005821 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 632335005822 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 632335005823 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632335005824 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 632335005825 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632335005826 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 632335005827 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632335005828 active site 632335005829 NTP binding site [chemical binding]; other site 632335005830 metal binding triad [ion binding]; metal-binding site 632335005831 antibiotic binding site [chemical binding]; other site 632335005832 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 632335005833 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 632335005834 GatB domain; Region: GatB_Yqey; smart00845 632335005835 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 632335005836 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 632335005837 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 632335005838 CAAX protease self-immunity; Region: Abi; pfam02517 632335005839 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 632335005840 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 632335005841 putative active site [active] 632335005842 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335005843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335005844 Walker A/P-loop; other site 632335005845 ATP binding site [chemical binding]; other site 632335005846 Q-loop/lid; other site 632335005847 ABC transporter signature motif; other site 632335005848 Walker B; other site 632335005849 D-loop; other site 632335005850 H-loop/switch region; other site 632335005851 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 632335005852 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 632335005853 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 632335005854 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 632335005855 dimerization interface [polypeptide binding]; other site 632335005856 domain crossover interface; other site 632335005857 redox-dependent activation switch; other site 632335005858 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 632335005859 DNA-binding site [nucleotide binding]; DNA binding site 632335005860 RNA-binding motif; other site 632335005861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335005862 S-adenosylmethionine binding site [chemical binding]; other site 632335005863 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 632335005864 GTP-binding protein Der; Reviewed; Region: PRK00093 632335005865 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 632335005866 G1 box; other site 632335005867 GTP/Mg2+ binding site [chemical binding]; other site 632335005868 Switch I region; other site 632335005869 G2 box; other site 632335005870 Switch II region; other site 632335005871 G3 box; other site 632335005872 G4 box; other site 632335005873 G5 box; other site 632335005874 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 632335005875 G1 box; other site 632335005876 GTP/Mg2+ binding site [chemical binding]; other site 632335005877 Switch I region; other site 632335005878 G2 box; other site 632335005879 G3 box; other site 632335005880 Switch II region; other site 632335005881 G4 box; other site 632335005882 G5 box; other site 632335005883 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 632335005884 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632335005885 Protein of unknown function (DUF512); Region: DUF512; pfam04459 632335005886 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 632335005887 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 632335005888 substrate binding pocket [chemical binding]; other site 632335005889 dimer interface [polypeptide binding]; other site 632335005890 inhibitor binding site; inhibition site 632335005891 Protein of unknown function (DUF402); Region: DUF402; pfam04167 632335005892 sporulation sigma factor SigK; Reviewed; Region: PRK05803 632335005893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335005894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335005895 DNA binding residues [nucleotide binding] 632335005896 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 632335005897 Peptidase family U32; Region: Peptidase_U32; pfam01136 632335005898 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 632335005899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335005900 S-adenosylmethionine binding site [chemical binding]; other site 632335005901 YceG-like family; Region: YceG; pfam02618 632335005902 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 632335005903 dimerization interface [polypeptide binding]; other site 632335005904 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 632335005905 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 632335005906 G1 box; other site 632335005907 putative GEF interaction site [polypeptide binding]; other site 632335005908 GTP/Mg2+ binding site [chemical binding]; other site 632335005909 Switch I region; other site 632335005910 G2 box; other site 632335005911 G3 box; other site 632335005912 Switch II region; other site 632335005913 G4 box; other site 632335005914 G5 box; other site 632335005915 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 632335005916 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 632335005917 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 632335005918 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 632335005919 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 632335005920 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 632335005921 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 632335005922 NADP binding site [chemical binding]; other site 632335005923 homodimer interface [polypeptide binding]; other site 632335005924 active site 632335005925 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 632335005926 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 632335005927 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632335005928 substrate binding site [chemical binding]; other site 632335005929 ATP binding site [chemical binding]; other site 632335005930 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 632335005931 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 632335005932 active site 632335005933 intersubunit interface [polypeptide binding]; other site 632335005934 catalytic residue [active] 632335005935 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632335005936 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632335005937 Bacterial transcriptional regulator; Region: IclR; pfam01614 632335005938 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 632335005939 glyoxylate reductase; Reviewed; Region: PRK13243 632335005940 dimerization interface [polypeptide binding]; other site 632335005941 ligand binding site [chemical binding]; other site 632335005942 NADP binding site [chemical binding]; other site 632335005943 catalytic site [active] 632335005944 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632335005945 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632335005946 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 632335005947 intersubunit interface [polypeptide binding]; other site 632335005948 active site 632335005949 zinc binding site [ion binding]; other site 632335005950 Na+ binding site [ion binding]; other site 632335005951 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 632335005952 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 632335005953 N- and C-terminal domain interface [polypeptide binding]; other site 632335005954 putative active site [active] 632335005955 MgATP binding site [chemical binding]; other site 632335005956 catalytic site [active] 632335005957 metal binding site [ion binding]; metal-binding site 632335005958 putative xylulose binding site [chemical binding]; other site 632335005959 putative homodimer interface [polypeptide binding]; other site 632335005960 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632335005961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632335005962 putative DNA binding site [nucleotide binding]; other site 632335005963 putative Zn2+ binding site [ion binding]; other site 632335005964 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632335005965 S-layer homology domain; Region: SLH; pfam00395 632335005966 S-layer homology domain; Region: SLH; pfam00395 632335005967 Starch binding domain; Region: CBM_2; smart01065 632335005968 starch-binding site 2 [chemical binding]; other site 632335005969 starch-binding site 1 [chemical binding]; other site 632335005970 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 632335005971 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 632335005972 carbohydrate binding site [chemical binding]; other site 632335005973 pullulanase, type I; Region: pulA_typeI; TIGR02104 632335005974 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 632335005975 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 632335005976 Ca binding site [ion binding]; other site 632335005977 active site 632335005978 catalytic site [active] 632335005979 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 632335005980 Starch binding domain; Region: CBM_2; smart01065 632335005981 starch-binding site 2 [chemical binding]; other site 632335005982 starch-binding site 1 [chemical binding]; other site 632335005983 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632335005984 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 632335005985 active site 632335005986 metal binding site [ion binding]; metal-binding site 632335005987 xylose isomerase; Provisional; Region: PRK05474 632335005988 xylose isomerase; Region: xylose_isom_A; TIGR02630 632335005989 Helix-turn-helix domain; Region: HTH_17; pfam12728 632335005990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335005991 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632335005992 putative substrate translocation pore; other site 632335005993 Response regulator receiver domain; Region: Response_reg; pfam00072 632335005994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335005995 active site 632335005996 phosphorylation site [posttranslational modification] 632335005997 intermolecular recognition site; other site 632335005998 dimerization interface [polypeptide binding]; other site 632335005999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335006000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632335006001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335006002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632335006003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335006004 dimerization interface [polypeptide binding]; other site 632335006005 Histidine kinase; Region: His_kinase; pfam06580 632335006006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335006007 ATP binding site [chemical binding]; other site 632335006008 Mg2+ binding site [ion binding]; other site 632335006009 G-X-G motif; other site 632335006010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335006011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335006012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335006013 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 632335006014 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335006015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335006016 ABC-ATPase subunit interface; other site 632335006017 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632335006018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335006019 dimer interface [polypeptide binding]; other site 632335006020 conserved gate region; other site 632335006021 ABC-ATPase subunit interface; other site 632335006022 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 632335006023 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 632335006024 S-layer homology domain; Region: SLH; pfam00395 632335006025 S-layer homology domain; Region: SLH; pfam00395 632335006026 S-layer homology domain; Region: SLH; pfam00395 632335006027 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 632335006028 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 632335006029 dimer interface [polypeptide binding]; other site 632335006030 anticodon binding site; other site 632335006031 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 632335006032 homodimer interface [polypeptide binding]; other site 632335006033 motif 1; other site 632335006034 active site 632335006035 motif 2; other site 632335006036 GAD domain; Region: GAD; pfam02938 632335006037 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 632335006038 motif 3; other site 632335006039 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 632335006040 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 632335006041 dimer interface [polypeptide binding]; other site 632335006042 motif 1; other site 632335006043 active site 632335006044 motif 2; other site 632335006045 motif 3; other site 632335006046 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 632335006047 anticodon binding site; other site 632335006048 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335006049 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335006050 Integrase core domain; Region: rve; pfam00665 632335006051 CrcB-like protein; Region: CRCB; pfam02537 632335006052 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 632335006053 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 632335006054 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 632335006055 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 632335006056 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 632335006057 Cation efflux family; Region: Cation_efflux; pfam01545 632335006058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632335006059 salt bridge; other site 632335006060 sequence-specific DNA binding site [nucleotide binding]; other site 632335006061 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632335006062 active site 632335006063 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 632335006064 prolyl-tRNA synthetase; Provisional; Region: PRK09194 632335006065 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 632335006066 dimer interface [polypeptide binding]; other site 632335006067 motif 1; other site 632335006068 active site 632335006069 motif 2; other site 632335006070 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 632335006071 putative deacylase active site [active] 632335006072 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 632335006073 active site 632335006074 motif 3; other site 632335006075 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 632335006076 anticodon binding site; other site 632335006077 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 632335006078 Mechanosensitive ion channel; Region: MS_channel; pfam00924 632335006079 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 632335006080 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 632335006081 catalytic triad [active] 632335006082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 632335006083 phosphorylation site [posttranslational modification] 632335006084 intermolecular recognition site; other site 632335006085 ANTAR domain; Region: ANTAR; pfam03861 632335006086 GAF domain; Region: GAF_3; pfam13492 632335006087 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632335006088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335006089 Zn2+ binding site [ion binding]; other site 632335006090 Mg2+ binding site [ion binding]; other site 632335006091 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 632335006092 N- and C-terminal domain interface [polypeptide binding]; other site 632335006093 D-xylulose kinase; Region: XylB; TIGR01312 632335006094 active site 632335006095 MgATP binding site [chemical binding]; other site 632335006096 catalytic site [active] 632335006097 metal binding site [ion binding]; metal-binding site 632335006098 xylulose binding site [chemical binding]; other site 632335006099 homodimer interface [polypeptide binding]; other site 632335006100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632335006101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632335006102 DNA binding site [nucleotide binding] 632335006103 domain linker motif; other site 632335006104 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632335006105 dimerization interface [polypeptide binding]; other site 632335006106 ligand binding site [chemical binding]; other site 632335006107 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 632335006108 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 632335006109 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 632335006110 catalytic motif [active] 632335006111 Zn binding site [ion binding]; other site 632335006112 RibD C-terminal domain; Region: RibD_C; cl17279 632335006113 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 632335006114 Lumazine binding domain; Region: Lum_binding; pfam00677 632335006115 Lumazine binding domain; Region: Lum_binding; pfam00677 632335006116 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 632335006117 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 632335006118 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 632335006119 dimerization interface [polypeptide binding]; other site 632335006120 active site 632335006121 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 632335006122 homopentamer interface [polypeptide binding]; other site 632335006123 active site 632335006124 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 632335006125 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632335006126 Bacterial SH3 domain; Region: SH3_3; pfam08239 632335006127 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632335006128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 632335006129 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632335006130 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 632335006131 hypothetical protein; Reviewed; Region: PRK00024 632335006132 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 632335006133 MPN+ (JAMM) motif; other site 632335006134 Zinc-binding site [ion binding]; other site 632335006135 glycogen branching enzyme; Provisional; Region: PRK12313 632335006136 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 632335006137 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 632335006138 active site 632335006139 catalytic site [active] 632335006140 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 632335006141 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 632335006142 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 632335006143 ligand binding site; other site 632335006144 oligomer interface; other site 632335006145 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 632335006146 dimer interface [polypeptide binding]; other site 632335006147 N-terminal domain interface [polypeptide binding]; other site 632335006148 sulfate 1 binding site; other site 632335006149 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 632335006150 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 632335006151 ligand binding site; other site 632335006152 oligomer interface; other site 632335006153 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 632335006154 dimer interface [polypeptide binding]; other site 632335006155 N-terminal domain interface [polypeptide binding]; other site 632335006156 sulfate 1 binding site; other site 632335006157 glycogen synthase; Provisional; Region: glgA; PRK00654 632335006158 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 632335006159 ADP-binding pocket [chemical binding]; other site 632335006160 homodimer interface [polypeptide binding]; other site 632335006161 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 632335006162 homodimer interface [polypeptide binding]; other site 632335006163 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 632335006164 active site pocket [active] 632335006165 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 632335006166 active site 632335006167 catalytic triad [active] 632335006168 oxyanion hole [active] 632335006169 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632335006170 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632335006171 nucleotide binding site [chemical binding]; other site 632335006172 Protein of unknown function DUF72; Region: DUF72; pfam01904 632335006173 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 632335006174 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 632335006175 active site 632335006176 dimer interface [polypeptide binding]; other site 632335006177 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 632335006178 NodB motif; other site 632335006179 putative active site [active] 632335006180 putative catalytic site [active] 632335006181 Zn binding site [ion binding]; other site 632335006182 regulatory protein SpoVG; Reviewed; Region: PRK13259 632335006183 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 632335006184 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632335006185 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632335006186 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632335006187 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632335006188 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632335006189 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632335006190 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632335006191 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 632335006192 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335006193 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335006194 Integrase core domain; Region: rve; pfam00665 632335006195 DNA primase, catalytic core; Region: dnaG; TIGR01391 632335006196 CHC2 zinc finger; Region: zf-CHC2; cl17510 632335006197 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 632335006198 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 632335006199 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 632335006200 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 632335006201 MPN+ (JAMM) motif; other site 632335006202 Zinc-binding site [ion binding]; other site 632335006203 RecT family; Region: RecT; pfam03837 632335006204 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 632335006205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335006206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335006207 DNA binding residues [nucleotide binding] 632335006208 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 632335006209 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 632335006210 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632335006211 active site 632335006212 DNA binding site [nucleotide binding] 632335006213 Int/Topo IB signature motif; other site 632335006214 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14321 632335006215 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 632335006216 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 632335006217 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 632335006218 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 632335006219 RNA/DNA hybrid binding site [nucleotide binding]; other site 632335006220 active site 632335006221 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632335006222 replicative DNA helicase; Region: DnaB; TIGR00665 632335006223 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 632335006224 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 632335006225 Walker A motif; other site 632335006226 ATP binding site [chemical binding]; other site 632335006227 Walker B motif; other site 632335006228 DNA binding loops [nucleotide binding] 632335006229 Helix-turn-helix domain; Region: HTH_36; pfam13730 632335006230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632335006231 non-specific DNA binding site [nucleotide binding]; other site 632335006232 salt bridge; other site 632335006233 sequence-specific DNA binding site [nucleotide binding]; other site 632335006234 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632335006235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632335006236 non-specific DNA binding site [nucleotide binding]; other site 632335006237 salt bridge; other site 632335006238 sequence-specific DNA binding site [nucleotide binding]; other site 632335006239 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 632335006240 HaeIII restriction endonuclease; Region: RE_HaeIII; pfam09556 632335006241 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632335006242 putative DNA binding site [nucleotide binding]; other site 632335006243 putative Zn2+ binding site [ion binding]; other site 632335006244 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 632335006245 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632335006246 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632335006247 catalytic residue [active] 632335006248 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632335006249 Peptidase family M23; Region: Peptidase_M23; pfam01551 632335006250 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 632335006251 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 632335006252 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 632335006253 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 632335006254 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632335006255 dimer interface [polypeptide binding]; other site 632335006256 ssDNA binding site [nucleotide binding]; other site 632335006257 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632335006258 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 632335006259 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 632335006260 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 632335006261 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632335006262 Walker A motif; other site 632335006263 ATP binding site [chemical binding]; other site 632335006264 Walker B motif; other site 632335006265 AAA domain; Region: AAA_31; pfam13614 632335006266 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632335006267 P-loop; other site 632335006268 Magnesium ion binding site [ion binding]; other site 632335006269 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 632335006270 AAA domain; Region: AAA_31; pfam13614 632335006271 AAA domain; Region: AAA_31; pfam13614 632335006272 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632335006273 P-loop; other site 632335006274 Magnesium ion binding site [ion binding]; other site 632335006275 response regulator PleD; Reviewed; Region: pleD; PRK09581 632335006276 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 632335006277 KWG Leptospira; Region: KWG; pfam07656 632335006278 KWG Leptospira; Region: KWG; pfam07656 632335006279 KWG Leptospira; Region: KWG; pfam07656 632335006280 Fic/DOC family; Region: Fic; cl00960 632335006281 PemK-like protein; Region: PemK; pfam02452 632335006282 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632335006283 endonuclease III; Region: ENDO3c; smart00478 632335006284 minor groove reading motif; other site 632335006285 helix-hairpin-helix signature motif; other site 632335006286 substrate binding pocket [chemical binding]; other site 632335006287 active site 632335006288 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 632335006289 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 632335006290 putative active site [active] 632335006291 catalytic site [active] 632335006292 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 632335006293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335006294 ATP-binding site [chemical binding]; other site 632335006295 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 632335006296 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 632335006297 cofactor binding site; other site 632335006298 DNA binding site [nucleotide binding] 632335006299 substrate interaction site [chemical binding]; other site 632335006300 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 632335006301 putative active site [active] 632335006302 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 632335006303 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 632335006304 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 632335006305 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 632335006306 ATP binding site [chemical binding]; other site 632335006307 Mg2+ binding site [ion binding]; other site 632335006308 G-X-G motif; other site 632335006309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632335006310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632335006311 non-specific DNA binding site [nucleotide binding]; other site 632335006312 salt bridge; other site 632335006313 sequence-specific DNA binding site [nucleotide binding]; other site 632335006314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632335006315 non-specific DNA binding site [nucleotide binding]; other site 632335006316 salt bridge; other site 632335006317 sequence-specific DNA binding site [nucleotide binding]; other site 632335006318 Domain of unknown function (DUF4373); Region: DUF4373; pfam14297 632335006319 replicative DNA helicase; Region: DnaB; TIGR00665 632335006320 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632335006321 Walker A motif; other site 632335006322 ATP binding site [chemical binding]; other site 632335006323 Walker B motif; other site 632335006324 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 632335006325 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 632335006326 Actin interacting protein 3; Region: AIP3; pfam03915 632335006327 thymidine kinase; Provisional; Region: PRK04296 632335006328 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 632335006329 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 632335006330 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 632335006331 RNA binding site [nucleotide binding]; other site 632335006332 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 632335006333 RNA binding site [nucleotide binding]; other site 632335006334 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 632335006335 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632335006336 Walker A motif; other site 632335006337 ATP binding site [chemical binding]; other site 632335006338 Walker B motif; other site 632335006339 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 632335006340 PRTRC system protein D; Region: PRTRC_D; TIGR03739 632335006341 Mg binding site [ion binding]; other site 632335006342 nucleotide binding site [chemical binding]; other site 632335006343 putative protofilament interface [polypeptide binding]; other site 632335006344 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 632335006345 Domain of unknown function DUF87; Region: DUF87; pfam01935 632335006346 AAA-like domain; Region: AAA_10; pfam12846 632335006347 PrgI family protein; Region: PrgI; pfam12666 632335006348 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 632335006349 DNA-binding interface [nucleotide binding]; DNA binding site 632335006350 Helix-turn-helix domain; Region: HTH_17; pfam12728 632335006351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632335006352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632335006353 salt bridge; other site 632335006354 non-specific DNA binding site [nucleotide binding]; other site 632335006355 sequence-specific DNA binding site [nucleotide binding]; other site 632335006356 Domain of unknown function (DUF955); Region: DUF955; pfam06114 632335006357 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 632335006358 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 632335006359 Int/Topo IB signature motif; other site 632335006360 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 632335006361 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 632335006362 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 632335006363 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 632335006364 THF binding site; other site 632335006365 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 632335006366 substrate binding site [chemical binding]; other site 632335006367 THF binding site; other site 632335006368 zinc-binding site [ion binding]; other site 632335006369 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632335006370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335006371 active site 632335006372 phosphorylation site [posttranslational modification] 632335006373 intermolecular recognition site; other site 632335006374 dimerization interface [polypeptide binding]; other site 632335006375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335006376 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632335006377 Histidine kinase; Region: His_kinase; pfam06580 632335006378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335006379 ATP binding site [chemical binding]; other site 632335006380 Mg2+ binding site [ion binding]; other site 632335006381 G-X-G motif; other site 632335006382 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335006383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335006384 dimer interface [polypeptide binding]; other site 632335006385 conserved gate region; other site 632335006386 ABC-ATPase subunit interface; other site 632335006387 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632335006388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335006389 dimer interface [polypeptide binding]; other site 632335006390 conserved gate region; other site 632335006391 putative PBP binding loops; other site 632335006392 ABC-ATPase subunit interface; other site 632335006393 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335006394 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335006395 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335006396 Domain of unknown function (DUF377); Region: DUF377; pfam04041 632335006397 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 632335006398 active site 632335006399 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632335006400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632335006401 DNA binding site [nucleotide binding] 632335006402 domain linker motif; other site 632335006403 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632335006404 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 632335006405 dimerization interface [polypeptide binding]; other site 632335006406 putative active cleft [active] 632335006407 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 632335006408 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 632335006409 dimer interface [polypeptide binding]; other site 632335006410 substrate binding site [chemical binding]; other site 632335006411 metal binding site [ion binding]; metal-binding site 632335006412 MoxR-like ATPases [General function prediction only]; Region: COG0714 632335006413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335006414 Walker A motif; other site 632335006415 ATP binding site [chemical binding]; other site 632335006416 Walker B motif; other site 632335006417 arginine finger; other site 632335006418 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 632335006419 SmpB-tmRNA interface; other site 632335006420 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 632335006421 PemK-like protein; Region: PemK; pfam02452 632335006422 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 632335006423 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 632335006424 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632335006425 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335006426 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 632335006427 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 632335006428 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 632335006429 catalytic domain interface [polypeptide binding]; other site 632335006430 homodimer interface [polypeptide binding]; other site 632335006431 putative active site [active] 632335006432 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 632335006433 catalytic domain interface [polypeptide binding]; other site 632335006434 putative homodimer interface [polypeptide binding]; other site 632335006435 Protein of unknown function, DUF608; Region: DUF608; pfam04685 632335006436 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 632335006437 beta-galactosidase; Region: BGL; TIGR03356 632335006438 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 632335006439 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 632335006440 DNA binding site [nucleotide binding] 632335006441 active site 632335006442 TRAM domain; Region: TRAM; cl01282 632335006443 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 632335006444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335006445 S-adenosylmethionine binding site [chemical binding]; other site 632335006446 Hemerythrin; Region: Hemerythrin; cd12107 632335006447 Fe binding site [ion binding]; other site 632335006448 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 632335006449 Protein of unknown function DUF58; Region: DUF58; pfam01882 632335006450 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 632335006451 pullulanase, type I; Region: pulA_typeI; TIGR02104 632335006452 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 632335006453 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 632335006454 Ca binding site [ion binding]; other site 632335006455 active site 632335006456 catalytic site [active] 632335006457 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 632335006458 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632335006459 metal binding site [ion binding]; metal-binding site 632335006460 active site 632335006461 I-site; other site 632335006462 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 632335006463 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 632335006464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632335006465 Coenzyme A binding pocket [chemical binding]; other site 632335006466 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 632335006467 Glycoprotease family; Region: Peptidase_M22; pfam00814 632335006468 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 632335006469 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 632335006470 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 632335006471 active site 632335006472 putative GTP cyclohydrolase; Provisional; Region: PRK13674 632335006473 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 632335006474 active site 632335006475 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 632335006476 putative active site [active] 632335006477 S-layer homology domain; Region: SLH; pfam00395 632335006478 S-layer homology domain; Region: SLH; pfam00395 632335006479 Bacterial Ig-like domain; Region: Big_5; pfam13205 632335006480 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 632335006481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335006482 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632335006483 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335006484 DNA binding residues [nucleotide binding] 632335006485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632335006486 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 632335006487 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632335006488 anti sigma factor interaction site; other site 632335006489 regulatory phosphorylation site [posttranslational modification]; other site 632335006490 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 632335006491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632335006492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632335006493 DNA binding residues [nucleotide binding] 632335006494 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 632335006495 dipeptidase PepV; Reviewed; Region: PRK07318 632335006496 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 632335006497 active site 632335006498 metal binding site [ion binding]; metal-binding site 632335006499 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 632335006500 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632335006501 active site 632335006502 metal binding site [ion binding]; metal-binding site 632335006503 Uncharacterized conserved protein [Function unknown]; Region: COG0398 632335006504 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 632335006505 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 632335006506 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 632335006507 Domain of unknown function DUF20; Region: UPF0118; pfam01594 632335006508 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 632335006509 Peptidase family U32; Region: Peptidase_U32; pfam01136 632335006510 Collagenase; Region: DUF3656; pfam12392 632335006511 Peptidase family U32; Region: Peptidase_U32; cl03113 632335006512 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 632335006513 Cell division protein ZapA; Region: ZapA; pfam05164 632335006514 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 632335006515 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632335006516 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 632335006517 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 632335006518 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 632335006519 active site 632335006520 catalytic residues [active] 632335006521 metal binding site [ion binding]; metal-binding site 632335006522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632335006523 DNA-binding site [nucleotide binding]; DNA binding site 632335006524 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632335006525 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632335006526 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632335006527 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632335006528 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 632335006529 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 632335006530 putative ligand binding site [chemical binding]; other site 632335006531 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 632335006532 Ca binding site [ion binding]; other site 632335006533 carbohydrate binding site [chemical binding]; other site 632335006534 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 632335006535 Ca binding site [ion binding]; other site 632335006536 carbohydrate binding site [chemical binding]; other site 632335006537 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 632335006538 S-layer homology domain; Region: SLH; pfam00395 632335006539 S-layer homology domain; Region: SLH; pfam00395 632335006540 Amino acid permease; Region: AA_permease_2; pfam13520 632335006541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335006542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632335006543 putative substrate translocation pore; other site 632335006544 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632335006545 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 632335006546 putative active site [active] 632335006547 metal binding site [ion binding]; metal-binding site 632335006548 Predicted transcriptional regulators [Transcription]; Region: COG1733 632335006549 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 632335006550 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 632335006551 putative active site pocket [active] 632335006552 dimerization interface [polypeptide binding]; other site 632335006553 putative catalytic residue [active] 632335006554 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 632335006555 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 632335006556 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 632335006557 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 632335006558 active site 632335006559 HIGH motif; other site 632335006560 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 632335006561 KMSKS motif; other site 632335006562 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 632335006563 tRNA binding surface [nucleotide binding]; other site 632335006564 anticodon binding site; other site 632335006565 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 632335006566 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 632335006567 trimer interface [polypeptide binding]; other site 632335006568 active site 632335006569 substrate binding site [chemical binding]; other site 632335006570 CoA binding site [chemical binding]; other site 632335006571 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 632335006572 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632335006573 active site 632335006574 HIGH motif; other site 632335006575 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632335006576 active site 632335006577 KMSKS motif; other site 632335006578 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 632335006579 HEAT repeats; Region: HEAT_2; pfam13646 632335006580 rod shape-determining protein MreC; Provisional; Region: PRK13922 632335006581 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 632335006582 Dynamin family; Region: Dynamin_N; pfam00350 632335006583 G1 box; other site 632335006584 GTP/Mg2+ binding site [chemical binding]; other site 632335006585 G2 box; other site 632335006586 Switch I region; other site 632335006587 G3 box; other site 632335006588 Switch II region; other site 632335006589 G4 box; other site 632335006590 G5 box; other site 632335006591 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 632335006592 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 632335006593 Zn binding site [ion binding]; other site 632335006594 toxin interface [polypeptide binding]; other site 632335006595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632335006596 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632335006597 Probable transposase; Region: OrfB_IS605; pfam01385 632335006598 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335006599 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 632335006600 iron binding site [ion binding]; other site 632335006601 Predicted integral membrane protein [Function unknown]; Region: COG5652 632335006602 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335006603 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335006604 Integrase core domain; Region: rve; pfam00665 632335006605 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335006606 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 632335006607 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 632335006608 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 632335006609 active site 632335006610 homodimer interface [polypeptide binding]; other site 632335006611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632335006612 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 632335006613 NAD(P) binding site [chemical binding]; other site 632335006614 active site 632335006615 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 632335006616 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 632335006617 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 632335006618 NAD(P) binding site [chemical binding]; other site 632335006619 homodimer interface [polypeptide binding]; other site 632335006620 substrate binding site [chemical binding]; other site 632335006621 active site 632335006622 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 632335006623 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335006624 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 632335006625 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 632335006626 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 632335006627 inhibitor-cofactor binding pocket; inhibition site 632335006628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632335006629 catalytic residue [active] 632335006630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632335006631 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632335006632 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 632335006633 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632335006634 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 632335006635 NAD(P) binding site [chemical binding]; other site 632335006636 homodimer interface [polypeptide binding]; other site 632335006637 substrate binding site [chemical binding]; other site 632335006638 active site 632335006639 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 632335006640 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632335006641 active site 632335006642 S-layer homology domain; Region: SLH; pfam00395 632335006643 S-layer homology domain; Region: SLH; pfam00395 632335006644 S-layer homology domain; Region: SLH; pfam00395 632335006645 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 632335006646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335006647 FeS/SAM binding site; other site 632335006648 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 632335006649 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632335006650 active site 632335006651 NTP binding site [chemical binding]; other site 632335006652 metal binding triad [ion binding]; metal-binding site 632335006653 antibiotic binding site [chemical binding]; other site 632335006654 Uncharacterized conserved protein [Function unknown]; Region: COG2445 632335006655 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 632335006656 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632335006657 metal-binding site [ion binding] 632335006658 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632335006659 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632335006660 metal-binding site [ion binding] 632335006661 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632335006662 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632335006663 metal-binding site [ion binding] 632335006664 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632335006665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632335006666 motif II; other site 632335006667 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 632335006668 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 632335006669 DNA binding residues [nucleotide binding] 632335006670 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 632335006671 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 632335006672 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 632335006673 FOG: CBS domain [General function prediction only]; Region: COG0517 632335006674 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 632335006675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335006676 S-adenosylmethionine binding site [chemical binding]; other site 632335006677 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632335006678 Uncharacterized conserved protein [Function unknown]; Region: COG5464 632335006679 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 632335006680 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 632335006681 FtsX-like permease family; Region: FtsX; pfam02687 632335006682 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632335006683 FtsX-like permease family; Region: FtsX; pfam02687 632335006684 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632335006685 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632335006686 Walker A/P-loop; other site 632335006687 ATP binding site [chemical binding]; other site 632335006688 Q-loop/lid; other site 632335006689 ABC transporter signature motif; other site 632335006690 Walker B; other site 632335006691 D-loop; other site 632335006692 H-loop/switch region; other site 632335006693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632335006694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632335006695 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 632335006696 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 632335006697 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 632335006698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632335006699 Zn2+ binding site [ion binding]; other site 632335006700 Mg2+ binding site [ion binding]; other site 632335006701 S-layer homology domain; Region: SLH; pfam00395 632335006702 S-layer homology domain; Region: SLH; pfam00395 632335006703 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632335006704 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632335006705 FtsX-like permease family; Region: FtsX; pfam02687 632335006706 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632335006707 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632335006708 Walker A/P-loop; other site 632335006709 ATP binding site [chemical binding]; other site 632335006710 Q-loop/lid; other site 632335006711 ABC transporter signature motif; other site 632335006712 Walker B; other site 632335006713 D-loop; other site 632335006714 H-loop/switch region; other site 632335006715 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632335006716 E3 interaction surface; other site 632335006717 lipoyl attachment site [posttranslational modification]; other site 632335006718 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335006719 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 632335006720 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335006721 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 632335006722 S-layer homology domain; Region: SLH; pfam00395 632335006723 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632335006724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335006725 S-adenosylmethionine binding site [chemical binding]; other site 632335006726 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 632335006727 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 632335006728 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632335006729 carboxyltransferase (CT) interaction site; other site 632335006730 biotinylation site [posttranslational modification]; other site 632335006731 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 632335006732 oxaloacetate decarboxylase; Provisional; Region: PRK12331 632335006733 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 632335006734 active site 632335006735 catalytic residues [active] 632335006736 metal binding site [ion binding]; metal-binding site 632335006737 homodimer binding site [polypeptide binding]; other site 632335006738 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 632335006739 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632335006740 dimer interface [polypeptide binding]; other site 632335006741 putative CheW interface [polypeptide binding]; other site 632335006742 Cache domain; Region: Cache_1; pfam02743 632335006743 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335006744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335006745 dimer interface [polypeptide binding]; other site 632335006746 conserved gate region; other site 632335006747 putative PBP binding loops; other site 632335006748 ABC-ATPase subunit interface; other site 632335006749 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 632335006750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335006751 dimer interface [polypeptide binding]; other site 632335006752 conserved gate region; other site 632335006753 putative PBP binding loops; other site 632335006754 ABC-ATPase subunit interface; other site 632335006755 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335006756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335006757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632335006758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632335006759 DNA binding site [nucleotide binding] 632335006760 domain linker motif; other site 632335006761 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 632335006762 dimerization interface [polypeptide binding]; other site 632335006763 ligand binding site [chemical binding]; other site 632335006764 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 632335006765 active site 632335006766 conformational flexibility of ligand binding pocket; other site 632335006767 ADP-ribosylating toxin turn-turn motif; other site 632335006768 DNA polymerase IV; Reviewed; Region: PRK03103 632335006769 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 632335006770 active site 632335006771 DNA binding site [nucleotide binding] 632335006772 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335006773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335006774 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335006775 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 632335006776 Predicted ATPase [General function prediction only]; Region: COG4637 632335006777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335006778 Walker A/P-loop; other site 632335006779 ATP binding site [chemical binding]; other site 632335006780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 632335006781 Walker B; other site 632335006782 D-loop; other site 632335006783 H-loop/switch region; other site 632335006784 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632335006785 Helix-turn-helix domain; Region: HTH_38; pfam13936 632335006786 Integrase core domain; Region: rve; pfam00665 632335006787 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 632335006788 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 632335006789 glutaminase active site [active] 632335006790 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 632335006791 dimer interface [polypeptide binding]; other site 632335006792 active site 632335006793 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 632335006794 dimer interface [polypeptide binding]; other site 632335006795 active site 632335006796 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 632335006797 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 632335006798 active site 632335006799 substrate binding site [chemical binding]; other site 632335006800 metal binding site [ion binding]; metal-binding site 632335006801 MoxR-like ATPases [General function prediction only]; Region: COG0714 632335006802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335006803 Walker A motif; other site 632335006804 ATP binding site [chemical binding]; other site 632335006805 Walker B motif; other site 632335006806 H+ Antiporter protein; Region: 2A0121; TIGR00900 632335006807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335006808 putative substrate translocation pore; other site 632335006809 Predicted permeases [General function prediction only]; Region: COG0679 632335006810 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632335006811 TPP-binding site [chemical binding]; other site 632335006812 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 632335006813 PYR/PP interface [polypeptide binding]; other site 632335006814 dimer interface [polypeptide binding]; other site 632335006815 TPP binding site [chemical binding]; other site 632335006816 Helix-turn-helix domain; Region: HTH_18; pfam12833 632335006817 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335006818 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632335006819 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632335006820 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632335006821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335006822 dimer interface [polypeptide binding]; other site 632335006823 conserved gate region; other site 632335006824 ABC-ATPase subunit interface; other site 632335006825 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632335006826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632335006827 dimer interface [polypeptide binding]; other site 632335006828 conserved gate region; other site 632335006829 putative PBP binding loops; other site 632335006830 ABC-ATPase subunit interface; other site 632335006831 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632335006832 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632335006833 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632335006834 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632335006835 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632335006836 Rod binding protein; Region: Rod-binding; pfam10135 632335006837 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 632335006838 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 632335006839 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 632335006840 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 632335006841 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 632335006842 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 632335006843 rod shape-determining protein Mbl; Provisional; Region: PRK13928 632335006844 MreB and similar proteins; Region: MreB_like; cd10225 632335006845 nucleotide binding site [chemical binding]; other site 632335006846 Mg binding site [ion binding]; other site 632335006847 putative protofilament interaction site [polypeptide binding]; other site 632335006848 RodZ interaction site [polypeptide binding]; other site 632335006849 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 632335006850 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 632335006851 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 632335006852 protein binding site [polypeptide binding]; other site 632335006853 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 632335006854 Catalytic dyad [active] 632335006855 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 632335006856 S-layer homology domain; Region: SLH; pfam00395 632335006857 S-layer homology domain; Region: SLH; pfam00395 632335006858 S-layer homology domain; Region: SLH; pfam00395 632335006859 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 632335006860 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 632335006861 FMN binding site [chemical binding]; other site 632335006862 active site 632335006863 catalytic residues [active] 632335006864 substrate binding site [chemical binding]; other site 632335006865 TraX protein; Region: TraX; pfam05857 632335006866 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 632335006867 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 632335006868 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632335006869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335006870 Walker A/P-loop; other site 632335006871 ATP binding site [chemical binding]; other site 632335006872 Q-loop/lid; other site 632335006873 ABC transporter signature motif; other site 632335006874 Walker B; other site 632335006875 D-loop; other site 632335006876 H-loop/switch region; other site 632335006877 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 632335006878 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335006879 Walker A/P-loop; other site 632335006880 ATP binding site [chemical binding]; other site 632335006881 Q-loop/lid; other site 632335006882 ABC transporter signature motif; other site 632335006883 Walker B; other site 632335006884 D-loop; other site 632335006885 H-loop/switch region; other site 632335006886 Predicted transcriptional regulators [Transcription]; Region: COG1725 632335006887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632335006888 DNA-binding site [nucleotide binding]; DNA binding site 632335006889 S-layer homology domain; Region: SLH; pfam00395 632335006890 S-layer homology domain; Region: SLH; pfam00395 632335006891 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632335006892 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632335006893 Walker A/P-loop; other site 632335006894 ATP binding site [chemical binding]; other site 632335006895 Q-loop/lid; other site 632335006896 ABC transporter signature motif; other site 632335006897 Walker B; other site 632335006898 D-loop; other site 632335006899 H-loop/switch region; other site 632335006900 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632335006901 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632335006902 FtsX-like permease family; Region: FtsX; pfam02687 632335006903 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632335006904 E3 interaction surface; other site 632335006905 lipoyl attachment site [posttranslational modification]; other site 632335006906 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335006907 HlyD family secretion protein; Region: HlyD_2; pfam12700 632335006908 HlyD family secretion protein; Region: HlyD_3; pfam13437 632335006909 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632335006910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632335006911 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 632335006912 Walker A/P-loop; other site 632335006913 ATP binding site [chemical binding]; other site 632335006914 Q-loop/lid; other site 632335006915 ABC transporter signature motif; other site 632335006916 Walker B; other site 632335006917 D-loop; other site 632335006918 H-loop/switch region; other site 632335006919 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 632335006920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335006921 FeS/SAM binding site; other site 632335006922 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 632335006923 Fanconi anemia ID complex proteins FANCI and FANCD2; Region: FANC; cl17018 632335006924 ubiquitination site [posttranslational modification]; other site 632335006925 Transposase domain (DUF772); Region: DUF772; pfam05598 632335006926 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 632335006927 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335006928 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335006929 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335006930 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 632335006931 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 632335006932 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 632335006933 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 632335006934 L-lactate permease; Region: Lactate_perm; cl00701 632335006935 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 632335006936 putative subunit interface; other site 632335006937 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 632335006938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632335006939 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632335006940 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 632335006941 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632335006942 4Fe-4S binding domain; Region: Fer4; pfam00037 632335006943 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632335006944 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 632335006945 active site 632335006946 FMN binding site [chemical binding]; other site 632335006947 substrate binding site [chemical binding]; other site 632335006948 3Fe-4S cluster binding site [ion binding]; other site 632335006949 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 632335006950 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 632335006951 putative active site [active] 632335006952 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 632335006953 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 632335006954 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632335006955 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 632335006956 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 632335006957 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 632335006958 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 632335006959 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 632335006960 Nucleopolyhedrovirus P10 protein; Region: NPV_P10; cl17484 632335006961 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 632335006962 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335006963 Walker A/P-loop; other site 632335006964 ATP binding site [chemical binding]; other site 632335006965 Q-loop/lid; other site 632335006966 ABC transporter signature motif; other site 632335006967 Walker B; other site 632335006968 D-loop; other site 632335006969 H-loop/switch region; other site 632335006970 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 632335006971 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 632335006972 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 632335006973 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 632335006974 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 632335006975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335006976 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335006977 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335006978 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 632335006979 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 632335006980 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 632335006981 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 632335006982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 632335006983 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 632335006984 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 632335006985 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 632335006986 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 632335006987 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 632335006988 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335006989 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335006990 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335006991 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 632335006992 Predicted transcriptional regulators [Transcription]; Region: COG1725 632335006993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632335006994 DNA-binding site [nucleotide binding]; DNA binding site 632335006995 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632335006996 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335006997 Walker A/P-loop; other site 632335006998 ATP binding site [chemical binding]; other site 632335006999 Q-loop/lid; other site 632335007000 ABC transporter signature motif; other site 632335007001 Walker B; other site 632335007002 D-loop; other site 632335007003 H-loop/switch region; other site 632335007004 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 632335007005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632335007006 Walker A/P-loop; other site 632335007007 ATP binding site [chemical binding]; other site 632335007008 Q-loop/lid; other site 632335007009 ABC transporter signature motif; other site 632335007010 Walker B; other site 632335007011 D-loop; other site 632335007012 H-loop/switch region; other site 632335007013 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 632335007014 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 632335007015 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 632335007016 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632335007017 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632335007018 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632335007019 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632335007020 TM-ABC transporter signature motif; other site 632335007021 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 632335007022 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 632335007023 Walker A/P-loop; other site 632335007024 ATP binding site [chemical binding]; other site 632335007025 Q-loop/lid; other site 632335007026 ABC transporter signature motif; other site 632335007027 Walker B; other site 632335007028 D-loop; other site 632335007029 H-loop/switch region; other site 632335007030 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 632335007031 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 632335007032 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 632335007033 putative ligand binding site [chemical binding]; other site 632335007034 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 632335007035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335007036 dimerization interface [polypeptide binding]; other site 632335007037 Histidine kinase; Region: His_kinase; pfam06580 632335007038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335007039 ATP binding site [chemical binding]; other site 632335007040 Mg2+ binding site [ion binding]; other site 632335007041 G-X-G motif; other site 632335007042 Response regulator receiver domain; Region: Response_reg; pfam00072 632335007043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335007044 active site 632335007045 phosphorylation site [posttranslational modification] 632335007046 intermolecular recognition site; other site 632335007047 dimerization interface [polypeptide binding]; other site 632335007048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335007049 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632335007050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335007051 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 632335007052 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 632335007053 putative ligand binding site [chemical binding]; other site 632335007054 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335007055 dimerization interface [polypeptide binding]; other site 632335007056 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632335007057 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632335007058 dimer interface [polypeptide binding]; other site 632335007059 putative CheW interface [polypeptide binding]; other site 632335007060 O-Antigen ligase; Region: Wzy_C; pfam04932 632335007061 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632335007062 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335007063 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632335007064 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 632335007065 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 632335007066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632335007067 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 632335007068 NAD binding site [chemical binding]; other site 632335007069 putative substrate binding site 2 [chemical binding]; other site 632335007070 putative substrate binding site 1 [chemical binding]; other site 632335007071 active site 632335007072 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 632335007073 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 632335007074 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632335007075 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 632335007076 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632335007077 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 632335007078 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 632335007079 NADP binding site [chemical binding]; other site 632335007080 active site 632335007081 putative substrate binding site [chemical binding]; other site 632335007082 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 632335007083 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 632335007084 NADP-binding site; other site 632335007085 homotetramer interface [polypeptide binding]; other site 632335007086 substrate binding site [chemical binding]; other site 632335007087 homodimer interface [polypeptide binding]; other site 632335007088 active site 632335007089 S-layer homology domain; Region: SLH; pfam00395 632335007090 S-layer homology domain; Region: SLH; pfam00395 632335007091 S-layer homology domain; Region: SLH; pfam00395 632335007092 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 632335007093 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632335007094 Chain length determinant protein; Region: Wzz; cl15801 632335007095 S-layer homology domain; Region: SLH; pfam00395 632335007096 Bacterial Ig-like domain; Region: Big_5; pfam13205 632335007097 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632335007098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335007099 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632335007100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632335007101 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 632335007102 metal binding site [ion binding]; metal-binding site 632335007103 active site 632335007104 Cellulose binding domain; Region: CBM_3; pfam00942 632335007105 Cellulose binding domain; Region: CBM_3; cl03026 632335007106 YycH protein; Region: YycI; cl02015 632335007107 YycH protein; Region: YycH; pfam07435 632335007108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 632335007109 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632335007110 dimerization interface [polypeptide binding]; other site 632335007111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 632335007112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632335007113 dimer interface [polypeptide binding]; other site 632335007114 phosphorylation site [posttranslational modification] 632335007115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632335007116 ATP binding site [chemical binding]; other site 632335007117 Mg2+ binding site [ion binding]; other site 632335007118 G-X-G motif; other site 632335007119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632335007120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632335007121 active site 632335007122 phosphorylation site [posttranslational modification] 632335007123 intermolecular recognition site; other site 632335007124 dimerization interface [polypeptide binding]; other site 632335007125 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632335007126 DNA binding site [nucleotide binding] 632335007127 CTP synthetase; Validated; Region: pyrG; PRK05380 632335007128 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 632335007129 Catalytic site [active] 632335007130 active site 632335007131 UTP binding site [chemical binding]; other site 632335007132 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 632335007133 active site 632335007134 putative oxyanion hole; other site 632335007135 catalytic triad [active] 632335007136 S-layer homology domain; Region: SLH; pfam00395 632335007137 S-layer homology domain; Region: SLH; pfam00395 632335007138 S-layer homology domain; Region: SLH; pfam00395 632335007139 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 632335007140 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 632335007141 Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907 632335007142 ADP-ribose binding site [chemical binding]; other site 632335007143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632335007144 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632335007145 Probable transposase; Region: OrfB_IS605; pfam01385 632335007146 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335007147 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 632335007148 iron binding site [ion binding]; other site 632335007149 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 632335007150 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 632335007151 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632335007152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335007153 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 632335007154 putative ADP-binding pocket [chemical binding]; other site 632335007155 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 632335007156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335007157 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 632335007158 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 632335007159 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 632335007160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632335007161 O-Antigen ligase; Region: Wzy_C; pfam04932 632335007162 O-Antigen ligase; Region: Wzy_C; cl04850 632335007163 TPR repeat; Region: TPR_11; pfam13414 632335007164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632335007165 binding surface 632335007166 TPR motif; other site 632335007167 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632335007168 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 632335007169 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 632335007170 Integral membrane protein DUF95; Region: DUF95; cl00572 632335007171 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 632335007172 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632335007173 active site 632335007174 catalytic tetrad [active] 632335007175 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 632335007176 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 632335007177 GDP-binding site [chemical binding]; other site 632335007178 ACT binding site; other site 632335007179 IMP binding site; other site 632335007180 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632335007181 metal ion-dependent adhesion site (MIDAS); other site 632335007182 von Willebrand factor type A domain; Region: VWA_2; pfam13519 632335007183 metal ion-dependent adhesion site (MIDAS); other site 632335007184 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 632335007185 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 632335007186 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632335007187 metal ion-dependent adhesion site (MIDAS); other site 632335007188 Protein of unknown function DUF58; Region: DUF58; pfam01882 632335007189 MoxR-like ATPases [General function prediction only]; Region: COG0714 632335007190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632335007191 Walker A motif; other site 632335007192 ATP binding site [chemical binding]; other site 632335007193 Walker B motif; other site 632335007194 arginine finger; other site 632335007195 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 632335007196 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632335007197 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632335007198 Walker A/P-loop; other site 632335007199 ATP binding site [chemical binding]; other site 632335007200 Q-loop/lid; other site 632335007201 ABC transporter signature motif; other site 632335007202 Walker B; other site 632335007203 D-loop; other site 632335007204 H-loop/switch region; other site 632335007205 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 632335007206 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 632335007207 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632335007208 putative active site [active] 632335007209 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 632335007210 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 632335007211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335007212 ATP binding site [chemical binding]; other site 632335007213 putative Mg++ binding site [ion binding]; other site 632335007214 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 632335007215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335007216 nucleotide binding region [chemical binding]; other site 632335007217 ATP-binding site [chemical binding]; other site 632335007218 Repair protein; Region: Repair_PSII; pfam04536 632335007219 LemA family; Region: LemA; pfam04011 632335007220 KWG Leptospira; Region: KWG; pfam07656 632335007221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632335007222 Probable transposase; Region: OrfB_IS605; pfam01385 632335007223 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335007224 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632335007225 putative active site [active] 632335007226 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 632335007227 PLD-like domain; Region: PLDc_2; pfam13091 632335007228 putative homodimer interface [polypeptide binding]; other site 632335007229 putative active site [active] 632335007230 catalytic site [active] 632335007231 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632335007232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632335007233 ATP binding site [chemical binding]; other site 632335007234 putative Mg++ binding site [ion binding]; other site 632335007235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632335007236 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 632335007237 nucleotide binding region [chemical binding]; other site 632335007238 ATP-binding site [chemical binding]; other site 632335007239 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632335007240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632335007241 S-adenosylmethionine binding site [chemical binding]; other site 632335007242 peroxiredoxin; Provisional; Region: PRK13189 632335007243 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 632335007244 dimer interface [polypeptide binding]; other site 632335007245 decamer (pentamer of dimers) interface [polypeptide binding]; other site 632335007246 catalytic triad [active] 632335007247 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 632335007248 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632335007249 Family description; Region: UvrD_C_2; pfam13538 632335007250 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 632335007251 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632335007252 Catalytic site [active] 632335007253 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 632335007254 Beta propeller domain; Region: Beta_propel; pfam09826 632335007255 Archaeal ATPase; Region: Arch_ATPase; pfam01637 632335007256 AAA ATPase domain; Region: AAA_16; pfam13191 632335007257 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 632335007258 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 632335007259 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 632335007260 Restriction endonuclease; Region: Mrr_cat; pfam04471 632335007261 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 632335007262 S-layer homology domain; Region: SLH; pfam00395 632335007263 S-layer homology domain; Region: SLH; pfam00395 632335007264 S-layer homology domain; Region: SLH; pfam00395 632335007265 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 632335007266 Helix-turn-helix domain; Region: HTH_18; pfam12833 632335007267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632335007268 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 632335007269 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 632335007270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335007271 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632335007272 putative substrate translocation pore; other site 632335007273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632335007274 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 632335007275 biotin synthase; Provisional; Region: PRK07094 632335007276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632335007277 FeS/SAM binding site; other site 632335007278 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 632335007279 Transglycosylase; Region: Transgly; pfam00912 632335007280 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 632335007281 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632335007282 endoglucanase; Region: PLN02420 632335007283 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 632335007284 Cellulose binding domain; Region: CBM_3; pfam00942 632335007285 Cellulose binding domain; Region: CBM_3; pfam00942 632335007286 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 632335007287 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632335007288 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 632335007289 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 632335007290 nucleotide binding site [chemical binding]; other site 632335007291 putative NEF/HSP70 interaction site [polypeptide binding]; other site 632335007292 SBD interface [polypeptide binding]; other site 632335007293 Protein of unknown function (DUF904); Region: DUF904; pfam06005 632335007294 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632335007295 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 632335007296 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 632335007297 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 632335007298 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 632335007299 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632335007300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 632335007301 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 632335007302 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 632335007303 Family of unknown function (DUF694); Region: DUF694; pfam05107 632335007304 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730 632335007305 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 632335007306 HerA helicase [Replication, recombination, and repair]; Region: COG0433 632335007307 Domain of unknown function DUF87; Region: DUF87; pfam01935 632335007308 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 632335007309 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 632335007310 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 632335007311 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 632335007312 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 632335007313 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 632335007314 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 632335007315 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 632335007316 CRISPR-associated protein, MJ1666 family; Region: cas_MJ1666; TIGR01897 632335007317 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 632335007318 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 632335007319 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 632335007320 active site 632335007321 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 632335007322 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 632335007323 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 632335007324 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 632335007325 RAMP superfamily; Region: RAMPs; pfam03787 632335007326 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 632335007327 BioY family; Region: BioY; pfam02632 632335007328 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 632335007329 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 632335007330 DNA binding site [nucleotide binding] 632335007331 AAA domain; Region: AAA_30; pfam13604 632335007332 Family description; Region: UvrD_C_2; pfam13538 632335007333 YvrJ protein family; Region: YvrJ; pfam12841 632335007334 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 632335007335 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 632335007336 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 632335007337 stage V sporulation protein AD; Validated; Region: PRK08304 632335007338 stage V sporulation protein AD; Provisional; Region: PRK12404 632335007339 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 632335007340 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 632335007341 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 632335007342 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 632335007343 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 632335007344 Family of unknown function (DUF694); Region: DUF694; pfam05107 632335007345 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 632335007346 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 632335007347 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 632335007348 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 632335007349 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 632335007350 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632335007351 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 632335007352 Family description; Region: UvrD_C_2; pfam13538 632335007353 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632335007354 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632335007355 Archaeal ATPase; Region: Arch_ATPase; pfam01637 632335007356 AAA domain; Region: AAA_14; pfam13173 632335007357 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 632335007358 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 632335007359 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 632335007360 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 632335007361 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 632335007362 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 632335007363 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 632335007364 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 632335007365 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 632335007366 hypothetical protein; Provisional; Region: PRK09956 632335007367 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632335007368 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 632335007369 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632335007370 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632335007371 substrate binding pocket [chemical binding]; other site 632335007372 membrane-bound complex binding site; other site 632335007373 hinge residues; other site 632335007374 PAS fold; Region: PAS; pfam00989 632335007375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632335007376 putative active site [active] 632335007377 heme pocket [chemical binding]; other site 632335007378 PAS fold; Region: PAS_3; pfam08447 632335007379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632335007380 heme pocket [chemical binding]; other site 632335007381 putative active site [active] 632335007382 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632335007383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632335007384 metal binding site [ion binding]; metal-binding site 632335007385 active site 632335007386 I-site; other site 632335007387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 632335007388 WYL domain; Region: WYL; pfam13280 632335007389 WYL domain; Region: WYL; pfam13280 632335007390 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 632335007391 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 632335007392 fumarate hydratase; Provisional; Region: PRK06246 632335007393 Colicin V production protein; Region: Colicin_V; pfam02674 632335007394 PAS fold; Region: PAS_4; pfam08448 632335007395 Protein of unknown function (DUF3629); Region: DUF3629; pfam12302 632335007396 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 632335007397 ParB-like nuclease domain; Region: ParB; smart00470 632335007398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 632335007399 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632335007400 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632335007401 P-loop; other site 632335007402 Magnesium ion binding site [ion binding]; other site 632335007403 Bacterial Ig-like domain; Region: Big_5; pfam13205 632335007404 PBP superfamily domain; Region: PBP_like_2; cl17296 632335007405 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632335007406 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 632335007407 dimer interface [polypeptide binding]; other site 632335007408 Alkaline phosphatase homologues; Region: alkPPc; smart00098 632335007409 active site 632335007410 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 632335007411 ParB-like nuclease domain; Region: ParB; smart00470 632335007412 KorB domain; Region: KorB; pfam08535 632335007413 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 632335007414 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 632335007415 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 632335007416 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 632335007417 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 632335007418 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 632335007419 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 632335007420 trmE is a tRNA modification GTPase; Region: trmE; cd04164 632335007421 G1 box; other site 632335007422 GTP/Mg2+ binding site [chemical binding]; other site 632335007423 Switch I region; other site 632335007424 G2 box; other site 632335007425 Switch II region; other site 632335007426 G3 box; other site 632335007427 G4 box; other site 632335007428 G5 box; other site 632335007429 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 632335007430 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 632335007431 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 632335007432 G-X-X-G motif; other site 632335007433 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 632335007434 RxxxH motif; other site 632335007435 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 632335007436 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 632335007437 Haemolytic domain; Region: Haemolytic; pfam01809 632335007438 Ribonuclease P; Region: Ribonuclease_P; cl00457 632335007439 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 632335007440 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 632335007441 Spore germination protein; Region: Spore_permease; cl17796 632335007442 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 632335007443 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504