-- dump date 20140619_020436 -- class Genbank::misc_feature -- table misc_feature_note -- id note 632516000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 632516000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 632516000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516000004 Walker A motif; other site 632516000005 ATP binding site [chemical binding]; other site 632516000006 Walker B motif; other site 632516000007 arginine finger; other site 632516000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 632516000009 DnaA box-binding interface [nucleotide binding]; other site 632516000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 632516000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 632516000012 putative DNA binding surface [nucleotide binding]; other site 632516000013 dimer interface [polypeptide binding]; other site 632516000014 beta-clamp/clamp loader binding surface; other site 632516000015 beta-clamp/translesion DNA polymerase binding surface; other site 632516000016 recombination protein F; Reviewed; Region: recF; PRK00064 632516000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516000018 Walker A/P-loop; other site 632516000019 ATP binding site [chemical binding]; other site 632516000020 Q-loop/lid; other site 632516000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516000022 ABC transporter signature motif; other site 632516000023 Walker B; other site 632516000024 D-loop; other site 632516000025 H-loop/switch region; other site 632516000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 632516000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516000028 ATP binding site [chemical binding]; other site 632516000029 Mg2+ binding site [ion binding]; other site 632516000030 G-X-G motif; other site 632516000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 632516000032 anchoring element; other site 632516000033 dimer interface [polypeptide binding]; other site 632516000034 ATP binding site [chemical binding]; other site 632516000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 632516000036 active site 632516000037 putative metal-binding site [ion binding]; other site 632516000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 632516000039 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 632516000040 DNA gyrase subunit A; Validated; Region: PRK05560 632516000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 632516000042 CAP-like domain; other site 632516000043 active site 632516000044 primary dimer interface [polypeptide binding]; other site 632516000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632516000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632516000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632516000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632516000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632516000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632516000051 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632516000052 lipoyl-biotinyl attachment site [posttranslational modification]; other site 632516000053 HlyD family secretion protein; Region: HlyD_3; pfam13437 632516000054 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632516000055 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632516000056 FtsX-like permease family; Region: FtsX; pfam02687 632516000057 Cellulose binding domain; Region: CBM_3; pfam00942 632516000058 Cellulose binding domain; Region: CBM_3; cl03026 632516000059 Cellulose binding domain; Region: CBM_3; cl03026 632516000060 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 632516000061 YycH protein; Region: YycI; cl02015 632516000062 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 632516000063 metal binding site [ion binding]; metal-binding site 632516000064 active site 632516000065 Cellulose binding domain; Region: CBM_3; pfam00942 632516000066 Cellulose binding domain; Region: CBM_3; cl03026 632516000067 Cellulose binding domain; Region: CBM_3; cl03026 632516000068 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 632516000069 endoglucanase; Region: PLN02420 632516000070 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 632516000071 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632516000072 dimerization interface [polypeptide binding]; other site 632516000073 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632516000074 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632516000075 dimer interface [polypeptide binding]; other site 632516000076 putative CheW interface [polypeptide binding]; other site 632516000077 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 632516000078 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 632516000079 putative ligand binding site [chemical binding]; other site 632516000080 Response regulator receiver domain; Region: Response_reg; pfam00072 632516000081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516000082 active site 632516000083 phosphorylation site [posttranslational modification] 632516000084 intermolecular recognition site; other site 632516000085 dimerization interface [polypeptide binding]; other site 632516000086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516000087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632516000088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516000089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516000090 ATP binding site [chemical binding]; other site 632516000091 Mg2+ binding site [ion binding]; other site 632516000092 G-X-G motif; other site 632516000093 Transposase IS200 like; Region: Y1_Tnp; pfam01797 632516000094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632516000095 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632516000096 Probable transposase; Region: OrfB_IS605; pfam01385 632516000097 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516000098 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 632516000099 iron binding site [ion binding]; other site 632516000100 Probable transposase; Region: OrfB_IS605; pfam01385 632516000101 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516000102 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632516000103 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632516000104 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 632516000105 FtsX-like permease family; Region: FtsX; pfam02687 632516000106 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 632516000107 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632516000108 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632516000109 Walker A/P-loop; other site 632516000110 ATP binding site [chemical binding]; other site 632516000111 Q-loop/lid; other site 632516000112 ABC transporter signature motif; other site 632516000113 Walker B; other site 632516000114 D-loop; other site 632516000115 H-loop/switch region; other site 632516000116 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 632516000117 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 632516000118 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 632516000119 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 632516000120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516000121 Walker A/P-loop; other site 632516000122 ATP binding site [chemical binding]; other site 632516000123 Q-loop/lid; other site 632516000124 ABC transporter signature motif; other site 632516000125 Walker B; other site 632516000126 D-loop; other site 632516000127 H-loop/switch region; other site 632516000128 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632516000129 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632516000130 Walker A/P-loop; other site 632516000131 ATP binding site [chemical binding]; other site 632516000132 Q-loop/lid; other site 632516000133 ABC transporter signature motif; other site 632516000134 Walker B; other site 632516000135 D-loop; other site 632516000136 H-loop/switch region; other site 632516000137 Predicted transcriptional regulators [Transcription]; Region: COG1725 632516000138 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632516000139 DNA-binding site [nucleotide binding]; DNA binding site 632516000140 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 632516000141 nucleoside/Zn binding site; other site 632516000142 dimer interface [polypeptide binding]; other site 632516000143 catalytic motif [active] 632516000144 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 632516000145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632516000146 ATP binding site [chemical binding]; other site 632516000147 Mg2+ binding site [ion binding]; other site 632516000148 G-X-G motif; other site 632516000149 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632516000150 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632516000151 putative DNA binding site [nucleotide binding]; other site 632516000152 putative Zn2+ binding site [ion binding]; other site 632516000153 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632516000154 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 632516000155 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 632516000156 N- and C-terminal domain interface [polypeptide binding]; other site 632516000157 putative active site [active] 632516000158 MgATP binding site [chemical binding]; other site 632516000159 catalytic site [active] 632516000160 metal binding site [ion binding]; metal-binding site 632516000161 putative xylulose binding site [chemical binding]; other site 632516000162 putative homodimer interface [polypeptide binding]; other site 632516000163 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 632516000164 intersubunit interface [polypeptide binding]; other site 632516000165 active site 632516000166 zinc binding site [ion binding]; other site 632516000167 Na+ binding site [ion binding]; other site 632516000168 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632516000169 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632516000170 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 632516000171 glyoxylate reductase; Reviewed; Region: PRK13243 632516000172 dimerization interface [polypeptide binding]; other site 632516000173 ligand binding site [chemical binding]; other site 632516000174 NADP binding site [chemical binding]; other site 632516000175 catalytic site [active] 632516000176 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632516000177 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632516000178 Bacterial transcriptional regulator; Region: IclR; pfam01614 632516000179 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 632516000180 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 632516000181 active site 632516000182 intersubunit interface [polypeptide binding]; other site 632516000183 catalytic residue [active] 632516000184 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 632516000185 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632516000186 substrate binding site [chemical binding]; other site 632516000187 ATP binding site [chemical binding]; other site 632516000188 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 632516000189 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 632516000190 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 632516000191 NADP binding site [chemical binding]; other site 632516000192 homodimer interface [polypeptide binding]; other site 632516000193 active site 632516000194 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 632516000195 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 632516000196 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 632516000197 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 632516000198 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 632516000199 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 632516000200 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 632516000201 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 632516000202 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 632516000203 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 632516000204 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 632516000205 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 632516000206 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 632516000207 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 632516000208 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632516000209 Walker A/P-loop; other site 632516000210 ATP binding site [chemical binding]; other site 632516000211 Q-loop/lid; other site 632516000212 ABC transporter signature motif; other site 632516000213 Walker B; other site 632516000214 D-loop; other site 632516000215 H-loop/switch region; other site 632516000216 Nucleopolyhedrovirus P10 protein; Region: NPV_P10; cl17484 632516000217 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 632516000218 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 632516000219 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 632516000220 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 632516000221 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632516000222 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 632516000223 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 632516000224 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 632516000225 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 632516000226 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 632516000227 putative active site [active] 632516000228 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632516000229 4Fe-4S binding domain; Region: Fer4; pfam00037 632516000230 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632516000231 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 632516000232 active site 632516000233 FMN binding site [chemical binding]; other site 632516000234 substrate binding site [chemical binding]; other site 632516000235 3Fe-4S cluster binding site [ion binding]; other site 632516000236 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 632516000237 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 632516000238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632516000239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632516000240 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 632516000241 putative subunit interface; other site 632516000242 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 632516000243 L-lactate permease; Region: Lactate_perm; cl00701 632516000244 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 632516000245 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 632516000246 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 632516000247 Predicted transcriptional regulators [Transcription]; Region: COG1725 632516000248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632516000249 DNA-binding site [nucleotide binding]; DNA binding site 632516000250 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 632516000251 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632516000252 Walker A/P-loop; other site 632516000253 ATP binding site [chemical binding]; other site 632516000254 Q-loop/lid; other site 632516000255 ABC transporter signature motif; other site 632516000256 Walker B; other site 632516000257 D-loop; other site 632516000258 H-loop/switch region; other site 632516000259 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632516000260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516000261 Walker A/P-loop; other site 632516000262 ATP binding site [chemical binding]; other site 632516000263 Q-loop/lid; other site 632516000264 ABC transporter signature motif; other site 632516000265 Walker B; other site 632516000266 D-loop; other site 632516000267 H-loop/switch region; other site 632516000268 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 632516000269 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 632516000270 TraX protein; Region: TraX; pfam05857 632516000271 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 632516000272 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 632516000273 FMN binding site [chemical binding]; other site 632516000274 active site 632516000275 catalytic residues [active] 632516000276 substrate binding site [chemical binding]; other site 632516000277 S-layer homology domain; Region: SLH; pfam00395 632516000278 S-layer homology domain; Region: SLH; pfam00395 632516000279 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 632516000280 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 632516000281 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 632516000282 protein binding site [polypeptide binding]; other site 632516000283 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 632516000284 Catalytic dyad [active] 632516000285 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 632516000286 rod shape-determining protein Mbl; Provisional; Region: PRK13928 632516000287 MreB and similar proteins; Region: MreB_like; cd10225 632516000288 nucleotide binding site [chemical binding]; other site 632516000289 Mg binding site [ion binding]; other site 632516000290 putative protofilament interaction site [polypeptide binding]; other site 632516000291 RodZ interaction site [polypeptide binding]; other site 632516000292 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 632516000293 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 632516000294 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 632516000295 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632516000296 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516000297 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 632516000298 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 632516000299 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 632516000300 Rod binding protein; Region: Rod-binding; pfam10135 632516000301 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632516000302 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632516000303 Metal-binding active site; metal-binding site 632516000304 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632516000305 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632516000306 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632516000307 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632516000308 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516000309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516000310 dimer interface [polypeptide binding]; other site 632516000311 conserved gate region; other site 632516000312 putative PBP binding loops; other site 632516000313 ABC-ATPase subunit interface; other site 632516000314 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632516000315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516000316 dimer interface [polypeptide binding]; other site 632516000317 conserved gate region; other site 632516000318 ABC-ATPase subunit interface; other site 632516000319 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516000320 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516000321 Helix-turn-helix domain; Region: HTH_18; pfam12833 632516000322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516000323 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632516000324 TPP-binding site [chemical binding]; other site 632516000325 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 632516000326 PYR/PP interface [polypeptide binding]; other site 632516000327 dimer interface [polypeptide binding]; other site 632516000328 TPP binding site [chemical binding]; other site 632516000329 Predicted permeases [General function prediction only]; Region: COG0679 632516000330 H+ Antiporter protein; Region: 2A0121; TIGR00900 632516000331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516000332 putative substrate translocation pore; other site 632516000333 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 632516000334 active site 632516000335 catalytic triad [active] 632516000336 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 632516000337 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 632516000338 active site 632516000339 substrate binding site [chemical binding]; other site 632516000340 metal binding site [ion binding]; metal-binding site 632516000341 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 632516000342 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 632516000343 glutaminase active site [active] 632516000344 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 632516000345 dimer interface [polypeptide binding]; other site 632516000346 active site 632516000347 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 632516000348 dimer interface [polypeptide binding]; other site 632516000349 active site 632516000350 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516000351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516000352 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516000353 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632516000354 Helix-turn-helix domain; Region: HTH_38; pfam13936 632516000355 Integrase core domain; Region: rve; pfam00665 632516000356 Predicted ATPase [General function prediction only]; Region: COG4637 632516000357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516000358 Walker A/P-loop; other site 632516000359 ATP binding site [chemical binding]; other site 632516000360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516000361 Walker B; other site 632516000362 D-loop; other site 632516000363 H-loop/switch region; other site 632516000364 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 632516000365 Transposase domain (DUF772); Region: DUF772; pfam05598 632516000366 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516000367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516000368 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516000369 DNA polymerase IV; Reviewed; Region: PRK03103 632516000370 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 632516000371 active site 632516000372 DNA binding site [nucleotide binding] 632516000373 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 632516000374 active site 632516000375 conformational flexibility of ligand binding pocket; other site 632516000376 ADP-ribosylating toxin turn-turn motif; other site 632516000377 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632516000378 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632516000379 DNA binding site [nucleotide binding] 632516000380 domain linker motif; other site 632516000381 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 632516000382 dimerization interface [polypeptide binding]; other site 632516000383 ligand binding site [chemical binding]; other site 632516000384 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516000385 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516000386 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516000387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516000388 dimer interface [polypeptide binding]; other site 632516000389 conserved gate region; other site 632516000390 putative PBP binding loops; other site 632516000391 ABC-ATPase subunit interface; other site 632516000392 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516000393 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 632516000394 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632516000395 dimer interface [polypeptide binding]; other site 632516000396 putative CheW interface [polypeptide binding]; other site 632516000397 Cache domain; Region: Cache_1; pfam02743 632516000398 oxaloacetate decarboxylase; Provisional; Region: PRK12331 632516000399 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 632516000400 active site 632516000401 catalytic residues [active] 632516000402 metal binding site [ion binding]; metal-binding site 632516000403 homodimer binding site [polypeptide binding]; other site 632516000404 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 632516000405 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 632516000406 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632516000407 carboxyltransferase (CT) interaction site; other site 632516000408 biotinylation site [posttranslational modification]; other site 632516000409 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 632516000410 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632516000411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516000412 S-adenosylmethionine binding site [chemical binding]; other site 632516000413 S-layer homology domain; Region: SLH; pfam00395 632516000414 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 632516000415 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516000416 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516000417 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516000418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632516000419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632516000420 Walker A/P-loop; other site 632516000421 ATP binding site [chemical binding]; other site 632516000422 Q-loop/lid; other site 632516000423 ABC transporter signature motif; other site 632516000424 Walker B; other site 632516000425 D-loop; other site 632516000426 H-loop/switch region; other site 632516000427 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632516000428 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632516000429 FtsX-like permease family; Region: FtsX; pfam02687 632516000430 S-layer homology domain; Region: SLH; pfam00395 632516000431 S-layer homology domain; Region: SLH; pfam00395 632516000432 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 632516000433 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632516000434 Helix-turn-helix domain; Region: HTH_38; pfam13936 632516000435 Integrase core domain; Region: rve; pfam00665 632516000436 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 632516000437 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516000438 Zn2+ binding site [ion binding]; other site 632516000439 Mg2+ binding site [ion binding]; other site 632516000440 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 632516000441 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 632516000442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632516000443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632516000444 Transposase domain (DUF772); Region: DUF772; pfam05598 632516000445 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632516000446 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632516000447 Walker A/P-loop; other site 632516000448 ATP binding site [chemical binding]; other site 632516000449 Q-loop/lid; other site 632516000450 ABC transporter signature motif; other site 632516000451 Walker B; other site 632516000452 D-loop; other site 632516000453 H-loop/switch region; other site 632516000454 FtsX-like permease family; Region: FtsX; pfam02687 632516000455 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632516000456 putative active site [active] 632516000457 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 632516000458 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 632516000459 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632516000460 Uncharacterized conserved protein [Function unknown]; Region: COG5464 632516000461 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 632516000462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 632516000463 S-adenosylmethionine binding site [chemical binding]; other site 632516000464 FOG: CBS domain [General function prediction only]; Region: COG0517 632516000465 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 632516000466 AAA domain; Region: AAA_31; pfam13614 632516000467 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 632516000468 Walker A motif; other site 632516000469 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 632516000470 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 632516000471 gating phenylalanine in ion channel; other site 632516000472 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 632516000473 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 632516000474 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 632516000475 DNA binding residues [nucleotide binding] 632516000476 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 632516000477 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632516000478 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632516000479 metal-binding site [ion binding] 632516000480 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632516000481 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632516000482 metal-binding site [ion binding] 632516000483 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632516000484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516000485 motif II; other site 632516000486 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632516000487 metal-binding site [ion binding] 632516000488 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 632516000489 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632516000490 active site 632516000491 NTP binding site [chemical binding]; other site 632516000492 metal binding triad [ion binding]; metal-binding site 632516000493 antibiotic binding site [chemical binding]; other site 632516000494 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 632516000495 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516000496 FeS/SAM binding site; other site 632516000497 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 632516000498 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632516000499 Winged helix-turn helix; Region: HTH_29; pfam13551 632516000500 Integrase core domain; Region: rve; pfam00665 632516000501 S-layer homology domain; Region: SLH; pfam00395 632516000502 S-layer homology domain; Region: SLH; pfam00395 632516000503 S-layer homology domain; Region: SLH; pfam00395 632516000504 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 632516000505 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632516000506 active site 632516000507 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 632516000508 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632516000509 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 632516000510 NAD(P) binding site [chemical binding]; other site 632516000511 homodimer interface [polypeptide binding]; other site 632516000512 substrate binding site [chemical binding]; other site 632516000513 active site 632516000514 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632516000515 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 632516000516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632516000517 Coenzyme A binding pocket [chemical binding]; other site 632516000518 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 632516000519 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 632516000520 inhibitor-cofactor binding pocket; inhibition site 632516000521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516000522 catalytic residue [active] 632516000523 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516000524 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 632516000525 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 632516000526 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 632516000527 NAD(P) binding site [chemical binding]; other site 632516000528 homodimer interface [polypeptide binding]; other site 632516000529 substrate binding site [chemical binding]; other site 632516000530 active site 632516000531 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 632516000532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632516000533 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 632516000534 NAD(P) binding site [chemical binding]; other site 632516000535 active site 632516000536 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 632516000537 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 632516000538 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 632516000539 active site 632516000540 homodimer interface [polypeptide binding]; other site 632516000541 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516000542 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 632516000543 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516000544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516000545 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516000546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632516000547 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632516000548 Integrase core domain; Region: rve; pfam00665 632516000549 Predicted integral membrane protein [Function unknown]; Region: COG5652 632516000550 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 632516000551 Zn binding site [ion binding]; other site 632516000552 toxin interface [polypeptide binding]; other site 632516000553 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 632516000554 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 632516000555 Dynamin family; Region: Dynamin_N; pfam00350 632516000556 G1 box; other site 632516000557 GTP/Mg2+ binding site [chemical binding]; other site 632516000558 G2 box; other site 632516000559 Switch I region; other site 632516000560 G3 box; other site 632516000561 Switch II region; other site 632516000562 G4 box; other site 632516000563 G5 box; other site 632516000564 rod shape-determining protein MreC; Provisional; Region: PRK13922 632516000565 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 632516000566 HEAT repeats; Region: HEAT_2; pfam13646 632516000567 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 632516000568 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632516000569 active site 632516000570 HIGH motif; other site 632516000571 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632516000572 active site 632516000573 KMSKS motif; other site 632516000574 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 632516000575 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 632516000576 trimer interface [polypeptide binding]; other site 632516000577 active site 632516000578 substrate binding site [chemical binding]; other site 632516000579 CoA binding site [chemical binding]; other site 632516000580 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 632516000581 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 632516000582 active site 632516000583 HIGH motif; other site 632516000584 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 632516000585 KMSKS motif; other site 632516000586 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 632516000587 tRNA binding surface [nucleotide binding]; other site 632516000588 anticodon binding site; other site 632516000589 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 632516000590 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 632516000591 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 632516000592 putative active site pocket [active] 632516000593 dimerization interface [polypeptide binding]; other site 632516000594 putative catalytic residue [active] 632516000595 Predicted transcriptional regulators [Transcription]; Region: COG1733 632516000596 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 632516000597 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632516000598 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 632516000599 putative active site [active] 632516000600 metal binding site [ion binding]; metal-binding site 632516000601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516000602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632516000603 putative substrate translocation pore; other site 632516000604 Amino acid permease; Region: AA_permease_2; pfam13520 632516000605 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632516000606 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632516000607 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632516000608 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 632516000609 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 632516000610 putative ligand binding site [chemical binding]; other site 632516000611 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 632516000612 Ca binding site [ion binding]; other site 632516000613 carbohydrate binding site [chemical binding]; other site 632516000614 S-layer homology domain; Region: SLH; pfam00395 632516000615 S-layer homology domain; Region: SLH; pfam00395 632516000616 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632516000617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632516000618 DNA-binding site [nucleotide binding]; DNA binding site 632516000619 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632516000620 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632516000621 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 632516000622 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 632516000623 active site 632516000624 catalytic residues [active] 632516000625 metal binding site [ion binding]; metal-binding site 632516000626 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 632516000627 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 632516000628 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632516000629 Cell division protein ZapA; Region: ZapA; pfam05164 632516000630 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 632516000631 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 632516000632 Peptidase family U32; Region: Peptidase_U32; pfam01136 632516000633 Collagenase; Region: DUF3656; pfam12392 632516000634 Peptidase family U32; Region: Peptidase_U32; cl03113 632516000635 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 632516000636 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632516000637 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 632516000638 Uncharacterized conserved protein [Function unknown]; Region: COG0398 632516000639 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 632516000640 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 632516000641 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632516000642 active site 632516000643 metal binding site [ion binding]; metal-binding site 632516000644 dipeptidase PepV; Reviewed; Region: PRK07318 632516000645 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 632516000646 active site 632516000647 metal binding site [ion binding]; metal-binding site 632516000648 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 632516000649 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 632516000650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516000651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632516000652 DNA binding residues [nucleotide binding] 632516000653 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632516000654 anti sigma factor interaction site; other site 632516000655 regulatory phosphorylation site [posttranslational modification]; other site 632516000656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632516000657 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 632516000658 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 632516000659 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516000660 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632516000661 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632516000662 DNA binding residues [nucleotide binding] 632516000663 S-layer homology domain; Region: SLH; pfam00395 632516000664 S-layer homology domain; Region: SLH; pfam00395 632516000665 Bacterial Ig-like domain; Region: Big_5; pfam13205 632516000666 DNA polymerase I; Provisional; Region: PRK05755 632516000667 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 632516000668 active site 632516000669 putative GTP cyclohydrolase; Provisional; Region: PRK13674 632516000670 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 632516000671 Urease alpha-subunit, N-terminal domain; Region: Urease_alpha; pfam00449 632516000672 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 632516000673 active site 632516000674 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 632516000675 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 632516000676 Glycoprotease family; Region: Peptidase_M22; pfam00814 632516000677 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 632516000678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632516000679 Coenzyme A binding pocket [chemical binding]; other site 632516000680 HEPN domain; Region: HEPN; pfam05168 632516000681 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632516000682 active site 632516000683 NTP binding site [chemical binding]; other site 632516000684 metal binding triad [ion binding]; metal-binding site 632516000685 antibiotic binding site [chemical binding]; other site 632516000686 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 632516000687 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632516000688 metal binding site [ion binding]; metal-binding site 632516000689 active site 632516000690 I-site; other site 632516000691 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 632516000692 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 632516000693 pullulanase, type I; Region: pulA_typeI; TIGR02104 632516000694 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 632516000695 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 632516000696 Ca binding site [ion binding]; other site 632516000697 active site 632516000698 catalytic site [active] 632516000699 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 632516000700 Protein of unknown function DUF58; Region: DUF58; pfam01882 632516000701 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516000702 DNA binding domain, excisionase family; Region: excise; TIGR01764 632516000703 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 632516000704 AAA domain; Region: AAA_25; pfam13481 632516000705 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632516000706 Response regulator receiver domain; Region: Response_reg; pfam00072 632516000707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516000708 active site 632516000709 phosphorylation site [posttranslational modification] 632516000710 intermolecular recognition site; other site 632516000711 dimerization interface [polypeptide binding]; other site 632516000712 HEAT repeats; Region: HEAT_2; pfam13646 632516000713 HEAT repeats; Region: HEAT_2; pfam13646 632516000714 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 632516000715 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 632516000716 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632516000717 DXD motif; other site 632516000718 Hemerythrin; Region: Hemerythrin; cd12107 632516000719 Fe binding site [ion binding]; other site 632516000720 TRAM domain; Region: TRAM; cl01282 632516000721 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 632516000722 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 632516000723 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 632516000724 DNA binding site [nucleotide binding] 632516000725 active site 632516000726 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 632516000727 beta-galactosidase; Region: BGL; TIGR03356 632516000728 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 632516000729 catalytic domain interface [polypeptide binding]; other site 632516000730 putative homodimer interface [polypeptide binding]; other site 632516000731 Protein of unknown function, DUF608; Region: DUF608; pfam04685 632516000732 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 632516000733 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 632516000734 catalytic domain interface [polypeptide binding]; other site 632516000735 homodimer interface [polypeptide binding]; other site 632516000736 putative active site [active] 632516000737 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516000738 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 632516000739 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 632516000740 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632516000741 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 632516000742 PemK-like protein; Region: PemK; pfam02452 632516000743 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 632516000744 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 632516000745 SmpB-tmRNA interface; other site 632516000746 MoxR-like ATPases [General function prediction only]; Region: COG0714 632516000747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516000748 Walker A motif; other site 632516000749 ATP binding site [chemical binding]; other site 632516000750 Walker B motif; other site 632516000751 arginine finger; other site 632516000752 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 632516000753 dimer interface [polypeptide binding]; other site 632516000754 substrate binding site [chemical binding]; other site 632516000755 metal binding site [ion binding]; metal-binding site 632516000756 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 632516000757 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 632516000758 dimerization interface [polypeptide binding]; other site 632516000759 putative active cleft [active] 632516000760 Domain of unknown function (DUF377); Region: DUF377; pfam04041 632516000761 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 632516000762 active site 632516000763 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516000764 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516000765 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516000766 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632516000767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516000768 dimer interface [polypeptide binding]; other site 632516000769 conserved gate region; other site 632516000770 putative PBP binding loops; other site 632516000771 ABC-ATPase subunit interface; other site 632516000772 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516000774 dimer interface [polypeptide binding]; other site 632516000775 conserved gate region; other site 632516000776 ABC-ATPase subunit interface; other site 632516000777 HAMP domain; Region: HAMP; pfam00672 632516000778 Histidine kinase; Region: His_kinase; pfam06580 632516000779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516000780 ATP binding site [chemical binding]; other site 632516000781 Mg2+ binding site [ion binding]; other site 632516000782 G-X-G motif; other site 632516000783 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632516000784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516000785 active site 632516000786 phosphorylation site [posttranslational modification] 632516000787 intermolecular recognition site; other site 632516000788 dimerization interface [polypeptide binding]; other site 632516000789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516000790 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 632516000791 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 632516000792 THF binding site; other site 632516000793 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 632516000794 substrate binding site [chemical binding]; other site 632516000795 THF binding site; other site 632516000796 zinc-binding site [ion binding]; other site 632516000797 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 632516000798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516000799 Walker A motif; other site 632516000800 ATP binding site [chemical binding]; other site 632516000801 Walker B motif; other site 632516000802 arginine finger; other site 632516000803 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 632516000804 ATP cone domain; Region: ATP-cone; pfam03477 632516000805 Class III ribonucleotide reductase; Region: RNR_III; cd01675 632516000806 effector binding site; other site 632516000807 active site 632516000808 Zn binding site [ion binding]; other site 632516000809 glycine loop; other site 632516000810 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 632516000811 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632516000812 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632516000813 nucleotide binding site [chemical binding]; other site 632516000814 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 632516000815 active site 632516000816 catalytic triad [active] 632516000817 oxyanion hole [active] 632516000818 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632516000819 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632516000820 Helix-turn-helix domain; Region: HTH_38; pfam13936 632516000821 Integrase core domain; Region: rve; pfam00665 632516000822 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 632516000823 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 632516000824 DNA methylase; Region: N6_N4_Mtase; pfam01555 632516000825 DNA methylase; Region: N6_N4_Mtase; cl17433 632516000826 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 632516000827 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632516000828 active site 632516000829 DNA binding site [nucleotide binding] 632516000830 Int/Topo IB signature motif; other site 632516000831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 632516000832 MULE transposase domain; Region: MULE; pfam10551 632516000833 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 632516000834 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632516000835 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632516000836 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 632516000837 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632516000838 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 632516000839 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632516000840 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632516000841 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632516000842 pur operon repressor; Provisional; Region: PRK09213 632516000843 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 632516000844 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516000845 active site 632516000846 regulatory protein SpoVG; Reviewed; Region: PRK13259 632516000847 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 632516000848 NodB motif; other site 632516000849 putative active site [active] 632516000850 putative catalytic site [active] 632516000851 Zn binding site [ion binding]; other site 632516000852 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 632516000853 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 632516000854 active site 632516000855 dimer interface [polypeptide binding]; other site 632516000856 Protein of unknown function DUF72; Region: DUF72; pfam01904 632516000857 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632516000858 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632516000859 nucleotide binding site [chemical binding]; other site 632516000860 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 632516000861 active site 632516000862 catalytic triad [active] 632516000863 oxyanion hole [active] 632516000864 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 632516000865 homodimer interface [polypeptide binding]; other site 632516000866 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 632516000867 active site pocket [active] 632516000868 glycogen synthase; Provisional; Region: glgA; PRK00654 632516000869 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 632516000870 ADP-binding pocket [chemical binding]; other site 632516000871 homodimer interface [polypeptide binding]; other site 632516000872 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 632516000873 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 632516000874 ligand binding site; other site 632516000875 oligomer interface; other site 632516000876 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 632516000877 dimer interface [polypeptide binding]; other site 632516000878 N-terminal domain interface [polypeptide binding]; other site 632516000879 sulfate 1 binding site; other site 632516000880 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 632516000881 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 632516000882 ligand binding site; other site 632516000883 oligomer interface; other site 632516000884 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 632516000885 dimer interface [polypeptide binding]; other site 632516000886 N-terminal domain interface [polypeptide binding]; other site 632516000887 sulfate 1 binding site; other site 632516000888 glycogen branching enzyme; Provisional; Region: PRK12313 632516000889 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 632516000890 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 632516000891 active site 632516000892 catalytic site [active] 632516000893 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 632516000894 hypothetical protein; Reviewed; Region: PRK00024 632516000895 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 632516000896 MPN+ (JAMM) motif; other site 632516000897 Zinc-binding site [ion binding]; other site 632516000898 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 632516000899 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632516000900 Bacterial SH3 domain; Region: SH3_3; pfam08239 632516000901 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632516000902 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632516000903 Transposase domain (DUF772); Region: DUF772; pfam05598 632516000904 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632516000905 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 632516000906 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 632516000907 homopentamer interface [polypeptide binding]; other site 632516000908 active site 632516000909 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 632516000910 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 632516000911 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 632516000912 dimerization interface [polypeptide binding]; other site 632516000913 active site 632516000914 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 632516000915 Lumazine binding domain; Region: Lum_binding; pfam00677 632516000916 Lumazine binding domain; Region: Lum_binding; pfam00677 632516000917 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 632516000918 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 632516000919 catalytic motif [active] 632516000920 Zn binding site [ion binding]; other site 632516000921 RibD C-terminal domain; Region: RibD_C; cl17279 632516000922 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632516000923 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632516000924 DNA binding site [nucleotide binding] 632516000925 domain linker motif; other site 632516000926 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632516000927 dimerization interface [polypeptide binding]; other site 632516000928 ligand binding site [chemical binding]; other site 632516000929 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 632516000930 N- and C-terminal domain interface [polypeptide binding]; other site 632516000931 D-xylulose kinase; Region: XylB; TIGR01312 632516000932 active site 632516000933 MgATP binding site [chemical binding]; other site 632516000934 catalytic site [active] 632516000935 metal binding site [ion binding]; metal-binding site 632516000936 xylulose binding site [chemical binding]; other site 632516000937 homodimer interface [polypeptide binding]; other site 632516000938 GAF domain; Region: GAF_3; pfam13492 632516000939 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632516000940 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516000941 Zn2+ binding site [ion binding]; other site 632516000942 Mg2+ binding site [ion binding]; other site 632516000943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 632516000944 phosphorylation site [posttranslational modification] 632516000945 intermolecular recognition site; other site 632516000946 ANTAR domain; Region: ANTAR; pfam03861 632516000947 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 632516000948 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 632516000949 catalytic triad [active] 632516000950 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 632516000951 Mechanosensitive ion channel; Region: MS_channel; pfam00924 632516000952 prolyl-tRNA synthetase; Provisional; Region: PRK09194 632516000953 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 632516000954 dimer interface [polypeptide binding]; other site 632516000955 motif 1; other site 632516000956 active site 632516000957 motif 2; other site 632516000958 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 632516000959 putative deacylase active site [active] 632516000960 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 632516000961 active site 632516000962 motif 3; other site 632516000963 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 632516000964 anticodon binding site; other site 632516000965 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 632516000966 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516000967 active site 632516000968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632516000969 salt bridge; other site 632516000970 sequence-specific DNA binding site [nucleotide binding]; other site 632516000971 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516000972 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 632516000973 Cation efflux family; Region: Cation_efflux; pfam01545 632516000974 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 632516000975 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 632516000976 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 632516000977 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 632516000978 CrcB-like protein; Region: CRCB; pfam02537 632516000979 histidyl-tRNA synthetase; Region: hisS; TIGR00442 632516000980 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 632516000981 dimer interface [polypeptide binding]; other site 632516000982 motif 1; other site 632516000983 active site 632516000984 motif 2; other site 632516000985 motif 3; other site 632516000986 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 632516000987 anticodon binding site; other site 632516000988 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 632516000989 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 632516000990 dimer interface [polypeptide binding]; other site 632516000991 anticodon binding site; other site 632516000992 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 632516000993 homodimer interface [polypeptide binding]; other site 632516000994 motif 1; other site 632516000995 active site 632516000996 motif 2; other site 632516000997 GAD domain; Region: GAD; pfam02938 632516000998 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 632516000999 motif 3; other site 632516001000 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 632516001001 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 632516001002 S-layer homology domain; Region: SLH; pfam00395 632516001003 S-layer homology domain; Region: SLH; pfam00395 632516001004 S-layer homology domain; Region: SLH; pfam00395 632516001005 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632516001006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516001007 dimer interface [polypeptide binding]; other site 632516001008 conserved gate region; other site 632516001009 ABC-ATPase subunit interface; other site 632516001010 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516001011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516001012 ABC-ATPase subunit interface; other site 632516001013 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516001014 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 632516001015 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516001016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516001017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632516001018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632516001019 dimerization interface [polypeptide binding]; other site 632516001020 Histidine kinase; Region: His_kinase; pfam06580 632516001021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516001022 ATP binding site [chemical binding]; other site 632516001023 Mg2+ binding site [ion binding]; other site 632516001024 G-X-G motif; other site 632516001025 Response regulator receiver domain; Region: Response_reg; pfam00072 632516001026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516001027 active site 632516001028 phosphorylation site [posttranslational modification] 632516001029 intermolecular recognition site; other site 632516001030 dimerization interface [polypeptide binding]; other site 632516001031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516001032 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632516001033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516001034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516001035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632516001036 putative substrate translocation pore; other site 632516001037 Helix-turn-helix domain; Region: HTH_17; pfam12728 632516001038 xylose isomerase; Provisional; Region: PRK05474 632516001039 xylose isomerase; Region: xylose_isom_A; TIGR02630 632516001040 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 632516001041 active site 632516001042 metal binding site [ion binding]; metal-binding site 632516001043 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632516001044 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 632516001045 carbohydrate binding site [chemical binding]; other site 632516001046 pullulanase, type I; Region: pulA_typeI; TIGR02104 632516001047 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 632516001048 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 632516001049 Ca binding site [ion binding]; other site 632516001050 active site 632516001051 catalytic site [active] 632516001052 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 632516001053 Starch binding domain; Region: CBM_2; smart01065 632516001054 starch-binding site 2 [chemical binding]; other site 632516001055 starch-binding site 1 [chemical binding]; other site 632516001056 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 632516001057 Starch binding domain; Region: CBM_2; smart01065 632516001058 starch-binding site 2 [chemical binding]; other site 632516001059 S-layer homology domain; Region: SLH; pfam00395 632516001060 S-layer homology domain; Region: SLH; pfam00395 632516001061 Starch binding domain; Region: CBM_2; smart01065 632516001062 starch-binding site 2 [chemical binding]; other site 632516001063 starch-binding site 1 [chemical binding]; other site 632516001064 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632516001065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632516001066 putative DNA binding site [nucleotide binding]; other site 632516001067 putative Zn2+ binding site [ion binding]; other site 632516001068 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632516001069 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 632516001070 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 632516001071 N- and C-terminal domain interface [polypeptide binding]; other site 632516001072 putative active site [active] 632516001073 MgATP binding site [chemical binding]; other site 632516001074 catalytic site [active] 632516001075 metal binding site [ion binding]; metal-binding site 632516001076 putative xylulose binding site [chemical binding]; other site 632516001077 putative homodimer interface [polypeptide binding]; other site 632516001078 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 632516001079 intersubunit interface [polypeptide binding]; other site 632516001080 active site 632516001081 zinc binding site [ion binding]; other site 632516001082 Na+ binding site [ion binding]; other site 632516001083 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632516001084 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632516001085 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 632516001086 glyoxylate reductase; Reviewed; Region: PRK13243 632516001087 dimerization interface [polypeptide binding]; other site 632516001088 ligand binding site [chemical binding]; other site 632516001089 NADP binding site [chemical binding]; other site 632516001090 catalytic site [active] 632516001091 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632516001092 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632516001093 Bacterial transcriptional regulator; Region: IclR; pfam01614 632516001094 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 632516001095 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 632516001096 active site 632516001097 intersubunit interface [polypeptide binding]; other site 632516001098 catalytic residue [active] 632516001099 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 632516001100 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632516001101 substrate binding site [chemical binding]; other site 632516001102 ATP binding site [chemical binding]; other site 632516001103 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 632516001104 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 632516001105 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 632516001106 NADP binding site [chemical binding]; other site 632516001107 homodimer interface [polypeptide binding]; other site 632516001108 active site 632516001109 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 632516001110 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 632516001111 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 632516001112 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 632516001113 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516001114 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 632516001115 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 632516001116 G1 box; other site 632516001117 putative GEF interaction site [polypeptide binding]; other site 632516001118 GTP/Mg2+ binding site [chemical binding]; other site 632516001119 Switch I region; other site 632516001120 G2 box; other site 632516001121 G3 box; other site 632516001122 Switch II region; other site 632516001123 G4 box; other site 632516001124 G5 box; other site 632516001125 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 632516001126 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 632516001127 YceG-like family; Region: YceG; pfam02618 632516001128 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 632516001129 dimerization interface [polypeptide binding]; other site 632516001130 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 632516001131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516001132 S-adenosylmethionine binding site [chemical binding]; other site 632516001133 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 632516001134 Peptidase family U32; Region: Peptidase_U32; pfam01136 632516001135 Protein of unknown function (DUF402); Region: DUF402; pfam04167 632516001136 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 632516001137 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 632516001138 substrate binding pocket [chemical binding]; other site 632516001139 dimer interface [polypeptide binding]; other site 632516001140 inhibitor binding site; inhibition site 632516001141 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 632516001142 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632516001143 Protein of unknown function (DUF512); Region: DUF512; pfam04459 632516001144 GTP-binding protein Der; Reviewed; Region: PRK00093 632516001145 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 632516001146 G1 box; other site 632516001147 GTP/Mg2+ binding site [chemical binding]; other site 632516001148 Switch I region; other site 632516001149 G2 box; other site 632516001150 Switch II region; other site 632516001151 G3 box; other site 632516001152 G4 box; other site 632516001153 G5 box; other site 632516001154 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 632516001155 G1 box; other site 632516001156 GTP/Mg2+ binding site [chemical binding]; other site 632516001157 Switch I region; other site 632516001158 G2 box; other site 632516001159 G3 box; other site 632516001160 Switch II region; other site 632516001161 G4 box; other site 632516001162 G5 box; other site 632516001163 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 632516001164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516001165 S-adenosylmethionine binding site [chemical binding]; other site 632516001166 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 632516001167 DNA-binding site [nucleotide binding]; DNA binding site 632516001168 RNA-binding motif; other site 632516001169 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 632516001170 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 632516001171 dimerization interface [polypeptide binding]; other site 632516001172 domain crossover interface; other site 632516001173 redox-dependent activation switch; other site 632516001174 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 632516001175 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 632516001176 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 632516001177 putative active site [active] 632516001178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516001179 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516001180 CAAX protease self-immunity; Region: Abi; pfam02517 632516001181 Transposase domain (DUF772); Region: DUF772; pfam05598 632516001182 phosphodiesterase; Provisional; Region: PRK12704 632516001183 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 632516001184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516001185 Zn2+ binding site [ion binding]; other site 632516001186 Mg2+ binding site [ion binding]; other site 632516001187 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 632516001188 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632516001189 putative active site [active] 632516001190 metal binding site [ion binding]; metal-binding site 632516001191 homodimer binding site [polypeptide binding]; other site 632516001192 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 632516001193 NTPase; Region: NTPase_1; cl17478 632516001194 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 632516001195 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 632516001196 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 632516001197 Asp23 family; Region: Asp23; pfam03780 632516001198 Asp23 family; Region: Asp23; pfam03780 632516001199 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 632516001200 transcription antitermination factor NusB; Region: nusB; TIGR01951 632516001201 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 632516001202 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 632516001203 generic binding surface II; other site 632516001204 generic binding surface I; other site 632516001205 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 632516001206 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 632516001207 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 632516001208 substrate binding pocket [chemical binding]; other site 632516001209 chain length determination region; other site 632516001210 substrate-Mg2+ binding site; other site 632516001211 catalytic residues [active] 632516001212 aspartate-rich region 1; other site 632516001213 active site lid residues [active] 632516001214 aspartate-rich region 2; other site 632516001215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516001216 putative substrate translocation pore; other site 632516001217 stage V sporulation protein T; Region: spore_V_T; TIGR02851 632516001218 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 632516001219 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 632516001220 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632516001221 dimer interface [polypeptide binding]; other site 632516001222 PYR/PP interface [polypeptide binding]; other site 632516001223 TPP binding site [chemical binding]; other site 632516001224 substrate binding site [chemical binding]; other site 632516001225 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 632516001226 TPP-binding site; other site 632516001227 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 632516001228 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632516001229 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632516001230 acyl-activating enzyme (AAE) consensus motif; other site 632516001231 AMP binding site [chemical binding]; other site 632516001232 active site 632516001233 CoA binding site [chemical binding]; other site 632516001234 Predicted membrane protein [Function unknown]; Region: COG2323 632516001235 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 632516001236 CoA binding domain; Region: CoA_binding_2; pfam13380 632516001237 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 632516001238 active site 632516001239 catalytic residues [active] 632516001240 hypothetical protein; Validated; Region: PRK00068 632516001241 Protein of unknown function DUF89; Region: DUF89; cl15397 632516001242 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 632516001243 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 632516001244 active site 632516001245 Zn binding site [ion binding]; other site 632516001246 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 632516001247 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 632516001248 hypothetical protein; Provisional; Region: PRK11820 632516001249 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 632516001250 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 632516001251 hypothetical protein; Provisional; Region: PRK04323 632516001252 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 632516001253 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 632516001254 catalytic site [active] 632516001255 G-X2-G-X-G-K; other site 632516001256 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 632516001257 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 632516001258 Flavoprotein; Region: Flavoprotein; pfam02441 632516001259 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 632516001260 primosome assembly protein PriA; Validated; Region: PRK05580 632516001261 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516001262 ATP binding site [chemical binding]; other site 632516001263 putative Mg++ binding site [ion binding]; other site 632516001264 helicase superfamily c-terminal domain; Region: HELICc; smart00490 632516001265 ATP-binding site [chemical binding]; other site 632516001266 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 632516001267 active site 632516001268 catalytic residues [active] 632516001269 metal binding site [ion binding]; metal-binding site 632516001270 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 632516001271 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 632516001272 putative active site [active] 632516001273 substrate binding site [chemical binding]; other site 632516001274 putative cosubstrate binding site; other site 632516001275 catalytic site [active] 632516001276 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 632516001277 substrate binding site [chemical binding]; other site 632516001278 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 632516001279 NusB family; Region: NusB; pfam01029 632516001280 16S rRNA methyltransferase B; Provisional; Region: PRK14902 632516001281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516001282 S-adenosylmethionine binding site [chemical binding]; other site 632516001283 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 632516001284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516001285 FeS/SAM binding site; other site 632516001286 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 632516001287 Protein phosphatase 2C; Region: PP2C; pfam00481 632516001288 active site 632516001289 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632516001290 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632516001291 active site 632516001292 ATP binding site [chemical binding]; other site 632516001293 substrate binding site [chemical binding]; other site 632516001294 activation loop (A-loop); other site 632516001295 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632516001296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 632516001297 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632516001298 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632516001299 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632516001300 GTPase RsgA; Reviewed; Region: PRK00098 632516001301 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 632516001302 RNA binding site [nucleotide binding]; other site 632516001303 homodimer interface [polypeptide binding]; other site 632516001304 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 632516001305 GTP/Mg2+ binding site [chemical binding]; other site 632516001306 G4 box; other site 632516001307 G5 box; other site 632516001308 G1 box; other site 632516001309 Switch I region; other site 632516001310 G2 box; other site 632516001311 G3 box; other site 632516001312 Switch II region; other site 632516001313 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 632516001314 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 632516001315 substrate binding site [chemical binding]; other site 632516001316 hexamer interface [polypeptide binding]; other site 632516001317 metal binding site [ion binding]; metal-binding site 632516001318 ribosome maturation protein RimP; Reviewed; Region: PRK00092 632516001319 Sm and related proteins; Region: Sm_like; cl00259 632516001320 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 632516001321 putative oligomer interface [polypeptide binding]; other site 632516001322 putative RNA binding site [nucleotide binding]; other site 632516001323 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 632516001324 NusA N-terminal domain; Region: NusA_N; pfam08529 632516001325 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 632516001326 RNA binding site [nucleotide binding]; other site 632516001327 homodimer interface [polypeptide binding]; other site 632516001328 NusA-like KH domain; Region: KH_5; pfam13184 632516001329 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 632516001330 G-X-X-G motif; other site 632516001331 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 632516001332 putative RNA binding cleft [nucleotide binding]; other site 632516001333 translation initiation factor IF-2; Validated; Region: infB; PRK05306 632516001334 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 632516001335 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 632516001336 G1 box; other site 632516001337 putative GEF interaction site [polypeptide binding]; other site 632516001338 GTP/Mg2+ binding site [chemical binding]; other site 632516001339 Switch I region; other site 632516001340 G2 box; other site 632516001341 G3 box; other site 632516001342 Switch II region; other site 632516001343 G4 box; other site 632516001344 G5 box; other site 632516001345 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 632516001346 Translation-initiation factor 2; Region: IF-2; pfam11987 632516001347 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 632516001348 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 632516001349 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 632516001350 DHH family; Region: DHH; pfam01368 632516001351 DHHA1 domain; Region: DHHA1; pfam02272 632516001352 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 632516001353 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 632516001354 RNA binding site [nucleotide binding]; other site 632516001355 active site 632516001356 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 632516001357 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 632516001358 active site 632516001359 Riboflavin kinase; Region: Flavokinase; pfam01687 632516001360 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 632516001361 16S/18S rRNA binding site [nucleotide binding]; other site 632516001362 S13e-L30e interaction site [polypeptide binding]; other site 632516001363 25S rRNA binding site [nucleotide binding]; other site 632516001364 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 632516001365 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 632516001366 RNase E interface [polypeptide binding]; other site 632516001367 trimer interface [polypeptide binding]; other site 632516001368 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 632516001369 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 632516001370 RNase E interface [polypeptide binding]; other site 632516001371 trimer interface [polypeptide binding]; other site 632516001372 active site 632516001373 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 632516001374 putative nucleic acid binding region [nucleotide binding]; other site 632516001375 G-X-X-G motif; other site 632516001376 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 632516001377 RNA binding site [nucleotide binding]; other site 632516001378 domain interface; other site 632516001379 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 632516001380 Uncharacterized conserved protein [Function unknown]; Region: COG2966 632516001381 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 632516001382 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 632516001383 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 632516001384 dimer interface [polypeptide binding]; other site 632516001385 active site 632516001386 glycine-pyridoxal phosphate binding site [chemical binding]; other site 632516001387 folate binding site [chemical binding]; other site 632516001388 recombination factor protein RarA; Reviewed; Region: PRK13342 632516001389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516001390 Walker A motif; other site 632516001391 ATP binding site [chemical binding]; other site 632516001392 Walker B motif; other site 632516001393 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 632516001394 arginine finger; other site 632516001395 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 632516001396 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 632516001397 Malic enzyme, N-terminal domain; Region: malic; pfam00390 632516001398 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 632516001399 putative NAD(P) binding site [chemical binding]; other site 632516001400 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 632516001401 transcription termination factor Rho; Provisional; Region: PRK12608 632516001402 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632516001403 RNA binding site [nucleotide binding]; other site 632516001404 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632516001405 Walker A motif; other site 632516001406 ATP binding site [chemical binding]; other site 632516001407 Walker B motif; other site 632516001408 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 632516001409 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632516001410 active site 632516001411 metal binding site [ion binding]; metal-binding site 632516001412 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 632516001413 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 632516001414 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632516001415 minor groove reading motif; other site 632516001416 helix-hairpin-helix signature motif; other site 632516001417 substrate binding pocket [chemical binding]; other site 632516001418 active site 632516001419 Protease prsW family; Region: PrsW-protease; pfam13367 632516001420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632516001421 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632516001422 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516001423 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 632516001424 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 632516001425 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 632516001426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516001427 S-adenosylmethionine binding site [chemical binding]; other site 632516001428 peptide chain release factor 1; Validated; Region: prfA; PRK00591 632516001429 This domain is found in peptide chain release factors; Region: PCRF; smart00937 632516001430 RF-1 domain; Region: RF-1; pfam00472 632516001431 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 632516001432 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 632516001433 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 632516001434 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 632516001435 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 632516001436 ligand binding site [chemical binding]; other site 632516001437 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 632516001438 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 632516001439 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 632516001440 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 632516001441 Low molecular weight phosphatase family; Region: LMWPc; cd00115 632516001442 active site 632516001443 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 632516001444 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 632516001445 feedback inhibition sensing region; other site 632516001446 homohexameric interface [polypeptide binding]; other site 632516001447 nucleotide binding site [chemical binding]; other site 632516001448 N-acetyl-L-glutamate binding site [chemical binding]; other site 632516001449 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 632516001450 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632516001451 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 632516001452 AMIN domain; Region: AMIN; pfam11741 632516001453 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 632516001454 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632516001455 active site 632516001456 metal binding site [ion binding]; metal-binding site 632516001457 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 632516001458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516001459 active site 632516001460 motif I; other site 632516001461 motif II; other site 632516001462 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 632516001463 hydrogenase 4 subunit F; Validated; Region: PRK06458 632516001464 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 632516001465 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 632516001466 NADH dehydrogenase; Region: NADHdh; cl00469 632516001467 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 632516001468 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 632516001469 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 632516001470 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 632516001471 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 632516001472 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632516001473 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 632516001474 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 632516001475 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 632516001476 G1 box; other site 632516001477 GTP/Mg2+ binding site [chemical binding]; other site 632516001478 G2 box; other site 632516001479 G3 box; other site 632516001480 Switch II region; other site 632516001481 G4 box; other site 632516001482 G5 box; other site 632516001483 Acylphosphatase; Region: Acylphosphatase; pfam00708 632516001484 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 632516001485 HypF finger; Region: zf-HYPF; pfam07503 632516001486 HypF finger; Region: zf-HYPF; pfam07503 632516001487 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 632516001488 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632516001489 Walker B motif; other site 632516001490 HupF/HypC family; Region: HupF_HypC; pfam01455 632516001491 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 632516001492 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 632516001493 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 632516001494 dimerization interface [polypeptide binding]; other site 632516001495 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 632516001496 ATP binding site [chemical binding]; other site 632516001497 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 632516001498 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632516001499 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 632516001500 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632516001501 dimer interface [polypeptide binding]; other site 632516001502 PYR/PP interface [polypeptide binding]; other site 632516001503 TPP binding site [chemical binding]; other site 632516001504 substrate binding site [chemical binding]; other site 632516001505 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 632516001506 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632516001507 TPP-binding site [chemical binding]; other site 632516001508 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 632516001509 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 632516001510 VanW like protein; Region: VanW; pfam04294 632516001511 G5 domain; Region: G5; pfam07501 632516001512 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 632516001513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 632516001514 Haemolysin XhlA; Region: XhlA; pfam10779 632516001515 Haemagglutinin; Region: Hemagglutinin; pfam00509 632516001516 Predicted transcriptional regulator [Transcription]; Region: COG4189 632516001517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632516001518 dimerization interface [polypeptide binding]; other site 632516001519 putative DNA binding site [nucleotide binding]; other site 632516001520 putative Zn2+ binding site [ion binding]; other site 632516001521 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 632516001522 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 632516001523 alpha-galactosidase; Provisional; Region: PRK15076 632516001524 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 632516001525 NAD binding site [chemical binding]; other site 632516001526 sugar binding site [chemical binding]; other site 632516001527 divalent metal binding site [ion binding]; other site 632516001528 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 632516001529 dimer interface [polypeptide binding]; other site 632516001530 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 632516001531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632516001532 Coenzyme A binding pocket [chemical binding]; other site 632516001533 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 632516001534 active site 632516001535 putative DNA-binding cleft [nucleotide binding]; other site 632516001536 dimer interface [polypeptide binding]; other site 632516001537 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 632516001538 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 632516001539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516001540 Walker A motif; other site 632516001541 ATP binding site [chemical binding]; other site 632516001542 Walker B motif; other site 632516001543 arginine finger; other site 632516001544 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 632516001545 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 632516001546 Ligand Binding Site [chemical binding]; other site 632516001547 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 632516001548 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 632516001549 hypothetical protein; Provisional; Region: PRK14553 632516001550 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 632516001551 GTPase CgtA; Reviewed; Region: obgE; PRK12297 632516001552 GTP1/OBG; Region: GTP1_OBG; pfam01018 632516001553 Obg GTPase; Region: Obg; cd01898 632516001554 G1 box; other site 632516001555 GTP/Mg2+ binding site [chemical binding]; other site 632516001556 Switch I region; other site 632516001557 G2 box; other site 632516001558 G3 box; other site 632516001559 Switch II region; other site 632516001560 G4 box; other site 632516001561 G5 box; other site 632516001562 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 632516001563 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 632516001564 Probable transposase; Region: OrfB_IS605; pfam01385 632516001565 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516001566 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632516001567 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632516001568 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 632516001569 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632516001570 homodimer interface [polypeptide binding]; other site 632516001571 substrate-cofactor binding pocket; other site 632516001572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516001573 catalytic residue [active] 632516001574 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 632516001575 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 632516001576 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 632516001577 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 632516001578 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 632516001579 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 632516001580 active site 632516001581 dimer interface [polypeptide binding]; other site 632516001582 aspartate aminotransferase; Provisional; Region: PRK05764 632516001583 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632516001584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516001585 homodimer interface [polypeptide binding]; other site 632516001586 catalytic residue [active] 632516001587 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 632516001588 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 632516001589 tetramer interface [polypeptide binding]; other site 632516001590 active site 632516001591 reverse gyrase; Reviewed; Region: PRK09401 632516001592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516001593 ATP binding site [chemical binding]; other site 632516001594 TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove; Region: TOPRIM_TopoIA_RevGyr; cd03361 632516001595 active site 632516001596 putative interdomain interaction site [polypeptide binding]; other site 632516001597 putative metal-binding site [ion binding]; other site 632516001598 putative nucleotide binding site [chemical binding]; other site 632516001599 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 632516001600 domain I; other site 632516001601 DNA binding groove [nucleotide binding] 632516001602 phosphate binding site [ion binding]; other site 632516001603 domain II; other site 632516001604 domain III; other site 632516001605 nucleotide binding site [chemical binding]; other site 632516001606 catalytic site [active] 632516001607 domain IV; other site 632516001608 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 632516001609 putative allosteric regulatory site; other site 632516001610 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 632516001611 putative allosteric regulatory residue; other site 632516001612 dihydrodipicolinate reductase; Provisional; Region: PRK00048 632516001613 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 632516001614 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 632516001615 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 632516001616 dihydrodipicolinate synthase; Region: dapA; TIGR00674 632516001617 dimer interface [polypeptide binding]; other site 632516001618 active site 632516001619 catalytic residue [active] 632516001620 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 632516001621 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632516001622 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 632516001623 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 632516001624 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 632516001625 homotrimer interaction site [polypeptide binding]; other site 632516001626 zinc binding site [ion binding]; other site 632516001627 CDP-binding sites; other site 632516001628 NurA domain; Region: NurA; pfam09376 632516001629 HerA helicase [Replication, recombination, and repair]; Region: COG0433 632516001630 Domain of unknown function DUF87; Region: DUF87; pfam01935 632516001631 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 632516001632 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 632516001633 active site 632516001634 metal binding site [ion binding]; metal-binding site 632516001635 DNA binding site [nucleotide binding] 632516001636 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 632516001637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516001638 Walker A/P-loop; other site 632516001639 ATP binding site [chemical binding]; other site 632516001640 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 632516001641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516001642 ABC transporter signature motif; other site 632516001643 Walker B; other site 632516001644 D-loop; other site 632516001645 H-loop/switch region; other site 632516001646 hypothetical protein; Validated; Region: PRK00153 632516001647 recombination protein RecR; Reviewed; Region: recR; PRK00076 632516001648 RecR protein; Region: RecR; pfam02132 632516001649 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 632516001650 putative active site [active] 632516001651 putative metal-binding site [ion binding]; other site 632516001652 tetramer interface [polypeptide binding]; other site 632516001653 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632516001654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632516001655 NAD(P) binding site [chemical binding]; other site 632516001656 active site 632516001657 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 632516001658 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 632516001659 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 632516001660 active site 632516001661 tetramer interface; other site 632516001662 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 632516001663 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 632516001664 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 632516001665 active site 1 [active] 632516001666 active site 2 [active] 632516001667 putative phosphate acyltransferase; Provisional; Region: PRK05331 632516001668 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 632516001669 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 632516001670 dimer interface [polypeptide binding]; other site 632516001671 active site 632516001672 CoA binding pocket [chemical binding]; other site 632516001673 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 632516001674 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 632516001675 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 632516001676 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 632516001677 NAD(P) binding site [chemical binding]; other site 632516001678 homotetramer interface [polypeptide binding]; other site 632516001679 homodimer interface [polypeptide binding]; other site 632516001680 active site 632516001681 acyl carrier protein; Provisional; Region: acpP; PRK00982 632516001682 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 632516001683 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 632516001684 dimer interface [polypeptide binding]; other site 632516001685 active site 632516001686 ribonuclease III; Reviewed; Region: rnc; PRK00102 632516001687 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 632516001688 dimerization interface [polypeptide binding]; other site 632516001689 active site 632516001690 metal binding site [ion binding]; metal-binding site 632516001691 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 632516001692 dsRNA binding site [nucleotide binding]; other site 632516001693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516001694 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516001695 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516001696 PBP superfamily domain; Region: PBP_like_2; cl17296 632516001697 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632516001698 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 632516001699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516001700 dimer interface [polypeptide binding]; other site 632516001701 conserved gate region; other site 632516001702 putative PBP binding loops; other site 632516001703 ABC-ATPase subunit interface; other site 632516001704 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 632516001705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516001706 dimer interface [polypeptide binding]; other site 632516001707 conserved gate region; other site 632516001708 putative PBP binding loops; other site 632516001709 ABC-ATPase subunit interface; other site 632516001710 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 632516001711 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 632516001712 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 632516001713 Walker A/P-loop; other site 632516001714 ATP binding site [chemical binding]; other site 632516001715 Q-loop/lid; other site 632516001716 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 632516001717 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 632516001718 Q-loop/lid; other site 632516001719 ABC transporter signature motif; other site 632516001720 Walker B; other site 632516001721 D-loop; other site 632516001722 H-loop/switch region; other site 632516001723 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 632516001724 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 632516001725 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 632516001726 P loop; other site 632516001727 GTP binding site [chemical binding]; other site 632516001728 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 632516001729 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 632516001730 ligand binding site [chemical binding]; other site 632516001731 flexible hinge region; other site 632516001732 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 632516001733 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 632516001734 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632516001735 hybrid cluster protein; Provisional; Region: PRK05290 632516001736 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632516001737 ACS interaction site; other site 632516001738 CODH interaction site; other site 632516001739 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 632516001740 hybrid metal cluster; other site 632516001741 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 632516001742 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 632516001743 ATP-grasp domain; Region: ATP-grasp; pfam02222 632516001744 AIR carboxylase; Region: AIRC; pfam00731 632516001745 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 632516001746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516001747 putative substrate translocation pore; other site 632516001748 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 632516001749 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 632516001750 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 632516001751 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 632516001752 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 632516001753 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 632516001754 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 632516001755 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 632516001756 23S rRNA binding site [nucleotide binding]; other site 632516001757 L21 binding site [polypeptide binding]; other site 632516001758 L13 binding site [polypeptide binding]; other site 632516001759 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632516001760 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 632516001761 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 632516001762 hypothetical protein; Provisional; Region: PRK05473 632516001763 anion exchange protein; Region: ae; TIGR00834 632516001764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632516001765 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632516001766 active site 632516001767 catalytic tetrad [active] 632516001768 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632516001769 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 632516001770 Quinolinate synthetase A protein; Region: NadA; pfam02445 632516001771 L-aspartate oxidase; Provisional; Region: PRK06175 632516001772 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 632516001773 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632516001774 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 632516001775 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 632516001776 dimerization interface [polypeptide binding]; other site 632516001777 active site 632516001778 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 632516001779 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 632516001780 putative [4Fe-4S] binding site [ion binding]; other site 632516001781 putative molybdopterin cofactor binding site [chemical binding]; other site 632516001782 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 632516001783 molybdopterin cofactor binding site; other site 632516001784 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 632516001785 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 632516001786 GTP binding site; other site 632516001787 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 632516001788 nudix motif; other site 632516001789 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 632516001790 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 632516001791 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 632516001792 putative RNA binding site [nucleotide binding]; other site 632516001793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516001794 S-adenosylmethionine binding site [chemical binding]; other site 632516001795 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 632516001796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516001797 S-adenosylmethionine binding site [chemical binding]; other site 632516001798 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 632516001799 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 632516001800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632516001801 RNA binding surface [nucleotide binding]; other site 632516001802 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 632516001803 active site 632516001804 uracil binding [chemical binding]; other site 632516001805 Predicted membrane protein [Function unknown]; Region: COG3601 632516001806 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 632516001807 Asp23 family; Region: Asp23; pfam03780 632516001808 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 632516001809 DAK2 domain; Region: Dak2; pfam02734 632516001810 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 632516001811 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 632516001812 ssDNA binding site; other site 632516001813 generic binding surface II; other site 632516001814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516001815 ATP binding site [chemical binding]; other site 632516001816 putative Mg++ binding site [ion binding]; other site 632516001817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632516001818 nucleotide binding region [chemical binding]; other site 632516001819 ATP-binding site [chemical binding]; other site 632516001820 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 632516001821 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 632516001822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516001823 S-adenosylmethionine binding site [chemical binding]; other site 632516001824 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 632516001825 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 632516001826 active site 632516001827 (T/H)XGH motif; other site 632516001828 V-type ATP synthase subunit E; Provisional; Region: PRK01005 632516001829 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 632516001830 Nucleoside recognition; Region: Gate; pfam07670 632516001831 Transposase domain (DUF772); Region: DUF772; pfam05598 632516001832 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 632516001833 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 632516001834 active site 632516001835 nucleophile elbow; other site 632516001836 hypothetical protein; Provisional; Region: PRK13670 632516001837 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 632516001838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632516001839 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 632516001840 FAD binding site [chemical binding]; other site 632516001841 homotetramer interface [polypeptide binding]; other site 632516001842 substrate binding pocket [chemical binding]; other site 632516001843 catalytic base [active] 632516001844 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 632516001845 Ligand binding site [chemical binding]; other site 632516001846 Electron transfer flavoprotein domain; Region: ETF; pfam01012 632516001847 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 632516001848 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 632516001849 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 632516001850 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 632516001851 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 632516001852 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 632516001853 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 632516001854 inhibitor-cofactor binding pocket; inhibition site 632516001855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516001856 catalytic residue [active] 632516001857 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 632516001858 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632516001859 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 632516001860 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632516001861 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632516001862 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632516001863 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632516001864 putative trimer interface [polypeptide binding]; other site 632516001865 putative CoA binding site [chemical binding]; other site 632516001866 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 632516001867 putative trimer interface [polypeptide binding]; other site 632516001868 putative active site [active] 632516001869 putative substrate binding site [chemical binding]; other site 632516001870 putative CoA binding site [chemical binding]; other site 632516001871 O-Antigen ligase; Region: Wzy_C; pfam04932 632516001872 O-Antigen ligase; Region: Wzy_C; cl04850 632516001873 O-Antigen ligase; Region: Wzy_C; pfam04932 632516001874 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516001875 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 632516001876 Transcriptional regulator [Transcription]; Region: LytR; COG1316 632516001877 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 632516001878 Protein of unknown function, DUF624; Region: DUF624; pfam04854 632516001879 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 632516001880 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 632516001881 5S rRNA interface [nucleotide binding]; other site 632516001882 CTC domain interface [polypeptide binding]; other site 632516001883 L16 interface [polypeptide binding]; other site 632516001884 argininosuccinate lyase; Provisional; Region: PRK00855 632516001885 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 632516001886 active sites [active] 632516001887 tetramer interface [polypeptide binding]; other site 632516001888 argininosuccinate synthase; Provisional; Region: PRK13820 632516001889 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 632516001890 ANP binding site [chemical binding]; other site 632516001891 Substrate Binding Site II [chemical binding]; other site 632516001892 Substrate Binding Site I [chemical binding]; other site 632516001893 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 632516001894 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 632516001895 active site 632516001896 (T/H)XGH motif; other site 632516001897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516001898 Zn2+ binding site [ion binding]; other site 632516001899 Mg2+ binding site [ion binding]; other site 632516001900 Transcriptional regulator [Transcription]; Region: LytR; COG1316 632516001901 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 632516001902 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 632516001903 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 632516001904 HIGH motif; other site 632516001905 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632516001906 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 632516001907 active site 632516001908 KMSKS motif; other site 632516001909 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 632516001910 tRNA binding surface [nucleotide binding]; other site 632516001911 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 632516001912 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 632516001913 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 632516001914 SLBB domain; Region: SLBB; pfam10531 632516001915 comEA protein; Region: comE; TIGR01259 632516001916 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 632516001917 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 632516001918 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 632516001919 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 632516001920 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632516001921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516001922 Zn2+ binding site [ion binding]; other site 632516001923 Mg2+ binding site [ion binding]; other site 632516001924 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 632516001925 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 632516001926 active site 632516001927 PHP Thumb interface [polypeptide binding]; other site 632516001928 metal binding site [ion binding]; metal-binding site 632516001929 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 632516001930 generic binding surface II; other site 632516001931 generic binding surface I; other site 632516001932 transcription attenuation protein MtrB; Provisional; Region: PRK13251 632516001933 6-phosphofructokinase; Provisional; Region: PRK03202 632516001934 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 632516001935 active site 632516001936 ADP/pyrophosphate binding site [chemical binding]; other site 632516001937 dimerization interface [polypeptide binding]; other site 632516001938 allosteric effector site; other site 632516001939 fructose-1,6-bisphosphate binding site; other site 632516001940 pyruvate kinase; Provisional; Region: PRK06354 632516001941 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 632516001942 domain interfaces; other site 632516001943 active site 632516001944 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 632516001945 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632516001946 active site 632516001947 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 632516001948 Yqey-like protein; Region: YqeY; pfam09424 632516001949 YabP family; Region: YabP; cl06766 632516001950 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 632516001951 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 632516001952 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 632516001953 PhoH-like protein; Region: PhoH; pfam02562 632516001954 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 632516001955 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516001956 Zn2+ binding site [ion binding]; other site 632516001957 Mg2+ binding site [ion binding]; other site 632516001958 metal-binding heat shock protein; Provisional; Region: PRK00016 632516001959 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 632516001960 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 632516001961 active site 632516001962 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 632516001963 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 632516001964 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632516001965 Beta-Casp domain; Region: Beta-Casp; smart01027 632516001966 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632516001967 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 632516001968 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 632516001969 Tetramer interface [polypeptide binding]; other site 632516001970 active site 632516001971 FMN-binding site [chemical binding]; other site 632516001972 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 632516001973 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 632516001974 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 632516001975 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 632516001976 regulatory protein interface [polypeptide binding]; other site 632516001977 regulatory phosphorylation site [posttranslational modification]; other site 632516001978 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 632516001979 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632516001980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516001981 FeS/SAM binding site; other site 632516001982 TRAM domain; Region: TRAM; cl01282 632516001983 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 632516001984 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 632516001985 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 632516001986 dimer interface [polypeptide binding]; other site 632516001987 motif 1; other site 632516001988 active site 632516001989 motif 2; other site 632516001990 motif 3; other site 632516001991 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 632516001992 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 632516001993 putative tRNA-binding site [nucleotide binding]; other site 632516001994 B3/4 domain; Region: B3_4; pfam03483 632516001995 tRNA synthetase B5 domain; Region: B5; smart00874 632516001996 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 632516001997 dimer interface [polypeptide binding]; other site 632516001998 motif 1; other site 632516001999 motif 3; other site 632516002000 motif 2; other site 632516002001 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 632516002002 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 632516002003 Part of AAA domain; Region: AAA_19; pfam13245 632516002004 Family description; Region: UvrD_C_2; pfam13538 632516002005 Divergent PAP2 family; Region: DUF212; pfam02681 632516002006 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 632516002007 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 632516002008 TPP-binding site; other site 632516002009 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 632516002010 PYR/PP interface [polypeptide binding]; other site 632516002011 dimer interface [polypeptide binding]; other site 632516002012 TPP binding site [chemical binding]; other site 632516002013 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632516002014 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 632516002015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632516002016 RNA binding surface [nucleotide binding]; other site 632516002017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516002018 S-adenosylmethionine binding site [chemical binding]; other site 632516002019 DRTGG domain; Region: DRTGG; pfam07085 632516002020 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 632516002021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516002022 ATP binding site [chemical binding]; other site 632516002023 G-X-G motif; other site 632516002024 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 632516002025 4Fe-4S binding domain; Region: Fer4; pfam00037 632516002026 4Fe-4S binding domain; Region: Fer4; cl02805 632516002027 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 632516002028 Putative Fe-S cluster; Region: FeS; cl17515 632516002029 DRTGG domain; Region: DRTGG; pfam07085 632516002030 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 632516002031 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 632516002032 active site 632516002033 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632516002034 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 632516002035 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 632516002036 putative dimer interface [polypeptide binding]; other site 632516002037 [2Fe-2S] cluster binding site [ion binding]; other site 632516002038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632516002039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516002040 ATP binding site [chemical binding]; other site 632516002041 Mg2+ binding site [ion binding]; other site 632516002042 G-X-G motif; other site 632516002043 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 632516002044 dimer interface [polypeptide binding]; other site 632516002045 [2Fe-2S] cluster binding site [ion binding]; other site 632516002046 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 632516002047 dimer interface [polypeptide binding]; other site 632516002048 [2Fe-2S] cluster binding site [ion binding]; other site 632516002049 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 632516002050 SLBB domain; Region: SLBB; pfam10531 632516002051 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 632516002052 4Fe-4S binding domain; Region: Fer4; pfam00037 632516002053 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632516002054 4Fe-4S binding domain; Region: Fer4; pfam00037 632516002055 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 632516002056 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632516002057 catalytic loop [active] 632516002058 iron binding site [ion binding]; other site 632516002059 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 632516002060 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 632516002061 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 632516002062 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 632516002063 Maf-like protein; Region: Maf; pfam02545 632516002064 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 632516002065 active site 632516002066 dimer interface [polypeptide binding]; other site 632516002067 rod shape-determining protein MreB; Provisional; Region: PRK13927 632516002068 MreB and similar proteins; Region: MreB_like; cd10225 632516002069 nucleotide binding site [chemical binding]; other site 632516002070 Mg binding site [ion binding]; other site 632516002071 putative protofilament interaction site [polypeptide binding]; other site 632516002072 RodZ interaction site [polypeptide binding]; other site 632516002073 rod shape-determining protein MreC; Provisional; Region: PRK13922 632516002074 rod shape-determining protein MreC; Region: MreC; pfam04085 632516002075 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 632516002076 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632516002077 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632516002078 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632516002079 septum formation inhibitor; Reviewed; Region: minC; PRK00513 632516002080 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 632516002081 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 632516002082 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 632516002083 P-loop; other site 632516002084 ADP binding residues [chemical binding]; other site 632516002085 Switch I; other site 632516002086 Switch II; other site 632516002087 Septum formation topological specificity factor MinE; Region: MinE; cl00538 632516002088 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 632516002089 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 632516002090 active site 632516002091 dimer interfaces [polypeptide binding]; other site 632516002092 catalytic residues [active] 632516002093 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 632516002094 Thiamine pyrophosphokinase; Region: TPK; cl08415 632516002095 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 632516002096 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 632516002097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632516002098 active site 632516002099 spermidine synthase; Provisional; Region: PRK00811 632516002100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516002101 agmatinase; Region: agmatinase; TIGR01230 632516002102 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 632516002103 putative active site [active] 632516002104 Mn binding site [ion binding]; other site 632516002105 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 632516002106 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632516002107 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632516002108 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 632516002109 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632516002110 carboxyltransferase (CT) interaction site; other site 632516002111 biotinylation site [posttranslational modification]; other site 632516002112 oxaloacetate decarboxylase; Provisional; Region: PRK12331 632516002113 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 632516002114 active site 632516002115 catalytic residues [active] 632516002116 metal binding site [ion binding]; metal-binding site 632516002117 homodimer binding site [polypeptide binding]; other site 632516002118 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 632516002119 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 632516002120 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 632516002121 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 632516002122 putative active site [active] 632516002123 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632516002124 catalytic core [active] 632516002125 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 632516002126 hexamer interface [polypeptide binding]; other site 632516002127 RNA binding site [nucleotide binding]; other site 632516002128 Histidine-zinc binding site [chemical binding]; other site 632516002129 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 632516002130 homotrimer interaction site [polypeptide binding]; other site 632516002131 active site 632516002132 cytidylate kinase; Provisional; Region: cmk; PRK00023 632516002133 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 632516002134 CMP-binding site; other site 632516002135 The sites determining sugar specificity; other site 632516002136 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632516002137 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632516002138 putative acyl-acceptor binding pocket; other site 632516002139 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 632516002140 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 632516002141 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 632516002142 RNA binding site [nucleotide binding]; other site 632516002143 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632516002144 RNA binding site [nucleotide binding]; other site 632516002145 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 632516002146 RNA binding site [nucleotide binding]; other site 632516002147 PRC-barrel domain; Region: PRC; pfam05239 632516002148 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 632516002149 Domain of unknown function DUF20; Region: UPF0118; pfam01594 632516002150 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 632516002151 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 632516002152 motif 1; other site 632516002153 active site 632516002154 motif 2; other site 632516002155 motif 3; other site 632516002156 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 632516002157 DHHA1 domain; Region: DHHA1; pfam02272 632516002158 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 632516002159 nucleotide binding site/active site [active] 632516002160 HIT family signature motif; other site 632516002161 catalytic residue [active] 632516002162 ATP-NAD kinase; Region: NAD_kinase; pfam01513 632516002163 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 632516002164 arginine repressor; Provisional; Region: argR; PRK00441 632516002165 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 632516002166 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 632516002167 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 632516002168 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 632516002169 Walker A/P-loop; other site 632516002170 ATP binding site [chemical binding]; other site 632516002171 Q-loop/lid; other site 632516002172 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 632516002173 ABC transporter signature motif; other site 632516002174 Walker B; other site 632516002175 D-loop; other site 632516002176 H-loop/switch region; other site 632516002177 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 632516002178 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 632516002179 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 632516002180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516002181 active site 632516002182 phosphorylation site [posttranslational modification] 632516002183 intermolecular recognition site; other site 632516002184 dimerization interface [polypeptide binding]; other site 632516002185 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 632516002186 stage V sporulation protein B; Region: spore_V_B; TIGR02900 632516002187 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 632516002188 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 632516002189 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 632516002190 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 632516002191 RNA/DNA hybrid binding site [nucleotide binding]; other site 632516002192 active site 632516002193 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 632516002194 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 632516002195 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 632516002196 dimer interface [polypeptide binding]; other site 632516002197 ADP-ribose binding site [chemical binding]; other site 632516002198 active site 632516002199 nudix motif; other site 632516002200 metal binding site [ion binding]; metal-binding site 632516002201 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 632516002202 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632516002203 PHP-associated; Region: PHP_C; pfam13263 632516002204 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 632516002205 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632516002206 catalytic residue [active] 632516002207 Protein of unknown function (DUF552); Region: DUF552; pfam04472 632516002208 YGGT family; Region: YGGT; pfam02325 632516002209 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 632516002210 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 632516002211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632516002212 RNA binding surface [nucleotide binding]; other site 632516002213 DivIVA protein; Region: DivIVA; pfam05103 632516002214 DivIVA domain; Region: DivI1A_domain; TIGR03544 632516002215 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 632516002216 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 632516002217 HIGH motif; other site 632516002218 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632516002219 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 632516002220 active site 632516002221 KMSKS motif; other site 632516002222 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 632516002223 tRNA binding surface [nucleotide binding]; other site 632516002224 anticodon binding site; other site 632516002225 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 632516002226 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 632516002227 active site 632516002228 dimer interface [polypeptide binding]; other site 632516002229 metal binding site [ion binding]; metal-binding site 632516002230 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516002231 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632516002232 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632516002233 Walker A/P-loop; other site 632516002234 ATP binding site [chemical binding]; other site 632516002235 Q-loop/lid; other site 632516002236 ABC transporter signature motif; other site 632516002237 Walker B; other site 632516002238 D-loop; other site 632516002239 H-loop/switch region; other site 632516002240 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 632516002241 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 632516002242 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 632516002243 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 632516002244 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632516002245 metal ion-dependent adhesion site (MIDAS); other site 632516002246 lipoprotein signal peptidase; Provisional; Region: PRK14787 632516002247 lipoprotein signal peptidase; Provisional; Region: PRK14791 632516002248 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632516002249 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632516002250 RNA binding surface [nucleotide binding]; other site 632516002251 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 632516002252 active site 632516002253 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 632516002254 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516002255 active site 632516002256 uracil transporter; Provisional; Region: PRK10720 632516002257 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 632516002258 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 632516002259 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 632516002260 dihydroorotase; Validated; Region: pyrC; PRK09357 632516002261 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632516002262 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 632516002263 active site 632516002264 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 632516002265 active site 632516002266 dimer interface [polypeptide binding]; other site 632516002267 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 632516002268 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632516002269 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 632516002270 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 632516002271 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632516002272 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632516002273 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 632516002274 IMP binding site; other site 632516002275 dimer interface [polypeptide binding]; other site 632516002276 interdomain contacts; other site 632516002277 partial ornithine binding site; other site 632516002278 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 632516002279 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 632516002280 FAD binding pocket [chemical binding]; other site 632516002281 FAD binding motif [chemical binding]; other site 632516002282 phosphate binding motif [ion binding]; other site 632516002283 beta-alpha-beta structure motif; other site 632516002284 NAD binding pocket [chemical binding]; other site 632516002285 Iron coordination center [ion binding]; other site 632516002286 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 632516002287 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 632516002288 heterodimer interface [polypeptide binding]; other site 632516002289 active site 632516002290 FMN binding site [chemical binding]; other site 632516002291 homodimer interface [polypeptide binding]; other site 632516002292 substrate binding site [chemical binding]; other site 632516002293 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632516002294 catalytic core [active] 632516002295 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516002296 active site 632516002297 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 632516002298 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 632516002299 Walker A/P-loop; other site 632516002300 ATP binding site [chemical binding]; other site 632516002301 Q-loop/lid; other site 632516002302 ABC transporter signature motif; other site 632516002303 Walker B; other site 632516002304 D-loop; other site 632516002305 H-loop/switch region; other site 632516002306 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 632516002307 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 632516002308 Walker A/P-loop; other site 632516002309 ATP binding site [chemical binding]; other site 632516002310 Q-loop/lid; other site 632516002311 ABC transporter signature motif; other site 632516002312 Walker B; other site 632516002313 D-loop; other site 632516002314 H-loop/switch region; other site 632516002315 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 632516002316 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 632516002317 TM-ABC transporter signature motif; other site 632516002318 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632516002319 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 632516002320 TM-ABC transporter signature motif; other site 632516002321 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 632516002322 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 632516002323 putative ligand binding site [chemical binding]; other site 632516002324 Uncharacterized conserved protein [Function unknown]; Region: COG1751 632516002325 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 632516002326 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632516002327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632516002328 active site 632516002329 DNA binding site [nucleotide binding] 632516002330 Int/Topo IB signature motif; other site 632516002331 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632516002332 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 632516002333 putative active site [active] 632516002334 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 632516002335 Glucuronate isomerase; Region: UxaC; pfam02614 632516002336 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 632516002337 enolase; Provisional; Region: eno; PRK00077 632516002338 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 632516002339 dimer interface [polypeptide binding]; other site 632516002340 metal binding site [ion binding]; metal-binding site 632516002341 substrate binding pocket [chemical binding]; other site 632516002342 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 632516002343 phosphoglyceromutase; Provisional; Region: PRK05434 632516002344 bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962 632516002345 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 632516002346 substrate binding site [chemical binding]; other site 632516002347 hinge regions; other site 632516002348 ADP binding site [chemical binding]; other site 632516002349 catalytic site [active] 632516002350 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 632516002351 substrate binding site [chemical binding]; other site 632516002352 dimer interface [polypeptide binding]; other site 632516002353 catalytic triad [active] 632516002354 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 632516002355 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 632516002356 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 632516002357 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 632516002358 Predicted transcriptional regulator [Transcription]; Region: COG3388 632516002359 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 632516002360 pyruvate phosphate dikinase; Provisional; Region: PRK09279 632516002361 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 632516002362 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632516002363 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 632516002364 glycyl-tRNA synthetase; Provisional; Region: PRK04173 632516002365 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 632516002366 dimer interface [polypeptide binding]; other site 632516002367 motif 1; other site 632516002368 active site 632516002369 motif 2; other site 632516002370 motif 3; other site 632516002371 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 632516002372 anticodon binding site; other site 632516002373 Recombination protein O N terminal; Region: RecO_N; pfam11967 632516002374 DNA repair protein RecO; Region: reco; TIGR00613 632516002375 Recombination protein O C terminal; Region: RecO_C; pfam02565 632516002376 GTPase Era; Reviewed; Region: era; PRK00089 632516002377 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 632516002378 G1 box; other site 632516002379 GTP/Mg2+ binding site [chemical binding]; other site 632516002380 Switch I region; other site 632516002381 G2 box; other site 632516002382 Switch II region; other site 632516002383 G3 box; other site 632516002384 G4 box; other site 632516002385 G5 box; other site 632516002386 KH domain; Region: KH_2; pfam07650 632516002387 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632516002388 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 632516002389 active site 632516002390 hypothetical protein; Validated; Region: PRK07682 632516002391 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632516002392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516002393 homodimer interface [polypeptide binding]; other site 632516002394 catalytic residue [active] 632516002395 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632516002396 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632516002397 AsnC family; Region: AsnC_trans_reg; pfam01037 632516002398 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 632516002399 trimer interface [polypeptide binding]; other site 632516002400 active site 632516002401 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 632516002402 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 632516002403 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632516002404 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 632516002405 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632516002406 HSP70 interaction site [polypeptide binding]; other site 632516002407 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25); Region: Herpes_pp85; pfam04637 632516002408 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 632516002409 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 632516002410 gamma subunit interface [polypeptide binding]; other site 632516002411 epsilon subunit interface [polypeptide binding]; other site 632516002412 LBP interface [polypeptide binding]; other site 632516002413 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 632516002414 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 632516002415 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 632516002416 alpha subunit interaction interface [polypeptide binding]; other site 632516002417 Walker A motif; other site 632516002418 ATP binding site [chemical binding]; other site 632516002419 Walker B motif; other site 632516002420 inhibitor binding site; inhibition site 632516002421 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 632516002422 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 632516002423 core domain interface [polypeptide binding]; other site 632516002424 delta subunit interface [polypeptide binding]; other site 632516002425 epsilon subunit interface [polypeptide binding]; other site 632516002426 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 632516002427 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 632516002428 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 632516002429 beta subunit interaction interface [polypeptide binding]; other site 632516002430 Walker A motif; other site 632516002431 ATP binding site [chemical binding]; other site 632516002432 Walker B motif; other site 632516002433 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 632516002434 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 632516002435 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 632516002436 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 632516002437 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 632516002438 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 632516002439 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 632516002440 GMP synthase; Reviewed; Region: guaA; PRK00074 632516002441 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 632516002442 AMP/PPi binding site [chemical binding]; other site 632516002443 candidate oxyanion hole; other site 632516002444 catalytic triad [active] 632516002445 potential glutamine specificity residues [chemical binding]; other site 632516002446 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 632516002447 ATP Binding subdomain [chemical binding]; other site 632516002448 Ligand Binding sites [chemical binding]; other site 632516002449 Dimerization subdomain; other site 632516002450 Predicted permeases [General function prediction only]; Region: COG0679 632516002451 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 632516002452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632516002453 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 632516002454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632516002455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632516002456 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 632516002457 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 632516002458 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 632516002459 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 632516002460 excinuclease ABC subunit B; Provisional; Region: PRK05298 632516002461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516002462 ATP binding site [chemical binding]; other site 632516002463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632516002464 nucleotide binding region [chemical binding]; other site 632516002465 ATP-binding site [chemical binding]; other site 632516002466 Ultra-violet resistance protein B; Region: UvrB; pfam12344 632516002467 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 632516002468 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632516002469 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632516002470 catalytic residue [active] 632516002471 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 632516002472 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 632516002473 CoA-binding site [chemical binding]; other site 632516002474 ATP-binding [chemical binding]; other site 632516002475 DNA polymerase I; Provisional; Region: PRK05755 632516002476 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 632516002477 active site 632516002478 metal binding site 1 [ion binding]; metal-binding site 632516002479 putative 5' ssDNA interaction site; other site 632516002480 metal binding site 3; metal-binding site 632516002481 metal binding site 2 [ion binding]; metal-binding site 632516002482 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 632516002483 putative DNA binding site [nucleotide binding]; other site 632516002484 putative metal binding site [ion binding]; other site 632516002485 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 632516002486 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 632516002487 active site 632516002488 DNA binding site [nucleotide binding] 632516002489 catalytic site [active] 632516002490 Rubredoxin [Energy production and conversion]; Region: COG1773 632516002491 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 632516002492 iron binding site [ion binding]; other site 632516002493 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 632516002494 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 632516002495 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 632516002496 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 632516002497 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 632516002498 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 632516002499 purine monophosphate binding site [chemical binding]; other site 632516002500 dimer interface [polypeptide binding]; other site 632516002501 putative catalytic residues [active] 632516002502 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 632516002503 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 632516002504 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 632516002505 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 632516002506 active site 632516002507 substrate binding site [chemical binding]; other site 632516002508 cosubstrate binding site; other site 632516002509 catalytic site [active] 632516002510 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 632516002511 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 632516002512 dimerization interface [polypeptide binding]; other site 632516002513 putative ATP binding site [chemical binding]; other site 632516002514 amidophosphoribosyltransferase; Provisional; Region: PRK05793 632516002515 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 632516002516 active site 632516002517 tetramer interface [polypeptide binding]; other site 632516002518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516002519 active site 632516002520 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 632516002521 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 632516002522 dimerization interface [polypeptide binding]; other site 632516002523 ATP binding site [chemical binding]; other site 632516002524 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 632516002525 dimerization interface [polypeptide binding]; other site 632516002526 ATP binding site [chemical binding]; other site 632516002527 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 632516002528 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 632516002529 putative active site [active] 632516002530 catalytic triad [active] 632516002531 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 632516002532 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 632516002533 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 632516002534 ATP binding site [chemical binding]; other site 632516002535 active site 632516002536 substrate binding site [chemical binding]; other site 632516002537 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 632516002538 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 632516002539 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632516002540 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632516002541 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632516002542 protein binding site [polypeptide binding]; other site 632516002543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632516002544 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632516002545 dimerization interface [polypeptide binding]; other site 632516002546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632516002547 dimer interface [polypeptide binding]; other site 632516002548 phosphorylation site [posttranslational modification] 632516002549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516002550 ATP binding site [chemical binding]; other site 632516002551 Mg2+ binding site [ion binding]; other site 632516002552 G-X-G motif; other site 632516002553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632516002554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516002555 active site 632516002556 phosphorylation site [posttranslational modification] 632516002557 intermolecular recognition site; other site 632516002558 dimerization interface [polypeptide binding]; other site 632516002559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632516002560 DNA binding site [nucleotide binding] 632516002561 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 632516002562 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 632516002563 dimerization interface [polypeptide binding]; other site 632516002564 putative ATP binding site [chemical binding]; other site 632516002565 Membrane protein of unknown function; Region: DUF360; cl00850 632516002566 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 632516002567 single-stranded DNA-binding protein; Provisional; Region: PRK05813 632516002568 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632516002569 dimer interface [polypeptide binding]; other site 632516002570 ssDNA binding site [nucleotide binding]; other site 632516002571 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632516002572 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 632516002573 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 632516002574 NodB motif; other site 632516002575 active site 632516002576 catalytic site [active] 632516002577 metal binding site [ion binding]; metal-binding site 632516002578 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 632516002579 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 632516002580 putative ATP binding site [chemical binding]; other site 632516002581 putative substrate interface [chemical binding]; other site 632516002582 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 632516002583 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 632516002584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 632516002585 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 632516002586 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 632516002587 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632516002588 minor groove reading motif; other site 632516002589 helix-hairpin-helix signature motif; other site 632516002590 substrate binding pocket [chemical binding]; other site 632516002591 active site 632516002592 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 632516002593 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 632516002594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632516002595 Coenzyme A binding pocket [chemical binding]; other site 632516002596 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 632516002597 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 632516002598 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 632516002599 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 632516002600 Substrate binding site; other site 632516002601 Cupin domain; Region: Cupin_2; cl17218 632516002602 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 632516002603 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 632516002604 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 632516002605 metal binding site [ion binding]; metal-binding site 632516002606 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 632516002607 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 632516002608 substrate binding site [chemical binding]; other site 632516002609 glutamase interaction surface [polypeptide binding]; other site 632516002610 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 632516002611 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 632516002612 catalytic residues [active] 632516002613 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 632516002614 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 632516002615 putative active site [active] 632516002616 oxyanion strand; other site 632516002617 catalytic triad [active] 632516002618 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 632516002619 putative active site pocket [active] 632516002620 4-fold oligomerization interface [polypeptide binding]; other site 632516002621 metal binding residues [ion binding]; metal-binding site 632516002622 3-fold/trimer interface [polypeptide binding]; other site 632516002623 histidinol-phosphate aminotransferase; Provisional; Region: PRK03967 632516002624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632516002625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516002626 homodimer interface [polypeptide binding]; other site 632516002627 catalytic residue [active] 632516002628 histidinol dehydrogenase; Region: hisD; TIGR00069 632516002629 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 632516002630 NAD binding site [chemical binding]; other site 632516002631 dimerization interface [polypeptide binding]; other site 632516002632 product binding site; other site 632516002633 substrate binding site [chemical binding]; other site 632516002634 zinc binding site [ion binding]; other site 632516002635 catalytic residues [active] 632516002636 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 632516002637 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 632516002638 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 632516002639 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 632516002640 dimer interface [polypeptide binding]; other site 632516002641 motif 1; other site 632516002642 active site 632516002643 motif 2; other site 632516002644 motif 3; other site 632516002645 QueT transporter; Region: QueT; pfam06177 632516002646 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 632516002647 PhoU domain; Region: PhoU; pfam01895 632516002648 PhoU domain; Region: PhoU; pfam01895 632516002649 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 632516002650 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 632516002651 Walker A/P-loop; other site 632516002652 ATP binding site [chemical binding]; other site 632516002653 Q-loop/lid; other site 632516002654 ABC transporter signature motif; other site 632516002655 Walker B; other site 632516002656 D-loop; other site 632516002657 H-loop/switch region; other site 632516002658 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 632516002659 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 632516002660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632516002661 dimer interface [polypeptide binding]; other site 632516002662 phosphorylation site [posttranslational modification] 632516002663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516002664 ATP binding site [chemical binding]; other site 632516002665 Mg2+ binding site [ion binding]; other site 632516002666 G-X-G motif; other site 632516002667 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632516002668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516002669 active site 632516002670 phosphorylation site [posttranslational modification] 632516002671 intermolecular recognition site; other site 632516002672 dimerization interface [polypeptide binding]; other site 632516002673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632516002674 DNA binding site [nucleotide binding] 632516002675 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 632516002676 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 632516002677 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 632516002678 active site 632516002679 intersubunit interactions; other site 632516002680 catalytic residue [active] 632516002681 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 632516002682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632516002683 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 632516002684 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632516002685 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 632516002686 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632516002687 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632516002688 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 632516002689 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 632516002690 HIGH motif; other site 632516002691 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632516002692 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 632516002693 active site 632516002694 KMSKS motif; other site 632516002695 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 632516002696 tRNA binding surface [nucleotide binding]; other site 632516002697 anticodon binding site; other site 632516002698 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 632516002699 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 632516002700 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 632516002701 non-heme iron binding site [ion binding]; other site 632516002702 dimer interface [polypeptide binding]; other site 632516002703 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 632516002704 non-heme iron binding site [ion binding]; other site 632516002705 dimer interface [polypeptide binding]; other site 632516002706 propionate/acetate kinase; Provisional; Region: PRK12379 632516002707 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632516002708 nucleotide binding site [chemical binding]; other site 632516002709 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 632516002710 LexA repressor; Validated; Region: PRK00215 632516002711 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 632516002712 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632516002713 Catalytic site [active] 632516002714 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 632516002715 Aluminium resistance protein; Region: Alum_res; pfam06838 632516002716 bacterial Hfq-like; Region: Hfq; cd01716 632516002717 hexamer interface [polypeptide binding]; other site 632516002718 Sm1 motif; other site 632516002719 RNA binding site [nucleotide binding]; other site 632516002720 Sm2 motif; other site 632516002721 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 632516002722 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 632516002723 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 632516002724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516002725 ATP binding site [chemical binding]; other site 632516002726 Mg2+ binding site [ion binding]; other site 632516002727 G-X-G motif; other site 632516002728 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 632516002729 ATP binding site [chemical binding]; other site 632516002730 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 632516002731 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 632516002732 MutS domain I; Region: MutS_I; pfam01624 632516002733 MutS domain II; Region: MutS_II; pfam05188 632516002734 MutS domain III; Region: MutS_III; pfam05192 632516002735 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 632516002736 Walker A/P-loop; other site 632516002737 ATP binding site [chemical binding]; other site 632516002738 Q-loop/lid; other site 632516002739 ABC transporter signature motif; other site 632516002740 Walker B; other site 632516002741 D-loop; other site 632516002742 H-loop/switch region; other site 632516002743 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 632516002744 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632516002745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516002746 FeS/SAM binding site; other site 632516002747 TRAM domain; Region: TRAM; pfam01938 632516002748 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 632516002749 ACT domain-containing protein [General function prediction only]; Region: COG4747 632516002750 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 632516002751 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 632516002752 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632516002753 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632516002754 acyl-activating enzyme (AAE) consensus motif; other site 632516002755 AMP binding site [chemical binding]; other site 632516002756 active site 632516002757 CoA binding site [chemical binding]; other site 632516002758 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 632516002759 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 632516002760 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632516002761 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632516002762 acyl-activating enzyme (AAE) consensus motif; other site 632516002763 AMP binding site [chemical binding]; other site 632516002764 active site 632516002765 CoA binding site [chemical binding]; other site 632516002766 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 632516002767 Clp amino terminal domain; Region: Clp_N; pfam02861 632516002768 Clp amino terminal domain; Region: Clp_N; pfam02861 632516002769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516002770 Walker A motif; other site 632516002771 ATP binding site [chemical binding]; other site 632516002772 Walker B motif; other site 632516002773 arginine finger; other site 632516002774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516002775 Walker A motif; other site 632516002776 ATP binding site [chemical binding]; other site 632516002777 Walker B motif; other site 632516002778 arginine finger; other site 632516002779 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 632516002780 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 632516002781 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 632516002782 putative dimer interface [polypeptide binding]; other site 632516002783 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 632516002784 ATP cone domain; Region: ATP-cone; pfam03477 632516002785 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 632516002786 GAF domain; Region: GAF_3; pfam13492 632516002787 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632516002788 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632516002789 metal binding site [ion binding]; metal-binding site 632516002790 active site 632516002791 I-site; other site 632516002792 Transposase, Mutator family; Region: Transposase_mut; pfam00872 632516002793 MULE transposase domain; Region: MULE; pfam10551 632516002794 Uncharacterized conserved protein [Function unknown]; Region: COG1615 632516002795 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 632516002796 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 632516002797 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 632516002798 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 632516002799 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 632516002800 DHH family; Region: DHH; pfam01368 632516002801 DHHA1 domain; Region: DHHA1; pfam02272 632516002802 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516002803 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 632516002804 S-adenosylmethionine synthetase; Validated; Region: PRK05250 632516002805 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 632516002806 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 632516002807 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 632516002808 Transposase domain (DUF772); Region: DUF772; pfam05598 632516002809 Uncharacterized conserved protein [Function unknown]; Region: COG0432 632516002810 Domain of unknown function (DUF377); Region: DUF377; pfam04041 632516002811 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 632516002812 active site 632516002813 KWG Leptospira; Region: KWG; pfam07656 632516002814 KWG Leptospira; Region: KWG; pfam07656 632516002815 KWG Leptospira; Region: KWG; pfam07656 632516002816 KWG Leptospira; Region: KWG; pfam07656 632516002817 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 632516002818 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632516002819 PYR/PP interface [polypeptide binding]; other site 632516002820 dimer interface [polypeptide binding]; other site 632516002821 TPP binding site [chemical binding]; other site 632516002822 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632516002823 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 632516002824 TPP-binding site [chemical binding]; other site 632516002825 dimer interface [polypeptide binding]; other site 632516002826 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 632516002827 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 632516002828 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 632516002829 homodimer interface [polypeptide binding]; other site 632516002830 substrate-cofactor binding pocket; other site 632516002831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516002832 catalytic residue [active] 632516002833 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 632516002834 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 632516002835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 632516002836 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 632516002837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 632516002838 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 632516002839 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 632516002840 dimer interface [polypeptide binding]; other site 632516002841 putative anticodon binding site; other site 632516002842 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 632516002843 motif 1; other site 632516002844 active site 632516002845 motif 2; other site 632516002846 motif 3; other site 632516002847 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 632516002848 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 632516002849 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 632516002850 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516002851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516002852 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516002853 Transposase, Mutator family; Region: Transposase_mut; pfam00872 632516002854 MULE transposase domain; Region: MULE; pfam10551 632516002855 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632516002856 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 632516002857 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 632516002858 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632516002859 Walker A/P-loop; other site 632516002860 ATP binding site [chemical binding]; other site 632516002861 Q-loop/lid; other site 632516002862 ABC transporter signature motif; other site 632516002863 Walker B; other site 632516002864 D-loop; other site 632516002865 H-loop/switch region; other site 632516002866 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 632516002867 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632516002868 HlyD family secretion protein; Region: HlyD_3; pfam13437 632516002869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632516002870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632516002871 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516002872 Transposase domain (DUF772); Region: DUF772; pfam05598 632516002873 CHC2 zinc finger; Region: zf-CHC2; pfam01807 632516002874 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 632516002875 active site 632516002876 metal binding site [ion binding]; metal-binding site 632516002877 interdomain interaction site; other site 632516002878 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632516002879 Walker A motif; other site 632516002880 ATP binding site [chemical binding]; other site 632516002881 Walker B motif; other site 632516002882 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632516002883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632516002884 non-specific DNA binding site [nucleotide binding]; other site 632516002885 salt bridge; other site 632516002886 sequence-specific DNA binding site [nucleotide binding]; other site 632516002887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632516002888 sequence-specific DNA binding site [nucleotide binding]; other site 632516002889 salt bridge; other site 632516002890 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632516002891 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632516002892 active site 632516002893 DNA binding site [nucleotide binding] 632516002894 Int/Topo IB signature motif; other site 632516002895 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 632516002896 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 632516002897 putative FMN binding site [chemical binding]; other site 632516002898 AAA domain; Region: AAA_32; pfam13654 632516002899 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 632516002900 RNA helicase; Region: RNA_helicase; pfam00910 632516002901 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 632516002902 Isopentenyl transferase; Region: IPT; pfam01745 632516002903 Asp23 family; Region: Asp23; cl00574 632516002904 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 632516002905 substrate binding site; other site 632516002906 dimer interface; other site 632516002907 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 632516002908 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632516002909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632516002910 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632516002911 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632516002912 active site residue [active] 632516002913 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632516002914 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516002915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516002916 Walker A/P-loop; other site 632516002917 ATP binding site [chemical binding]; other site 632516002918 Q-loop/lid; other site 632516002919 ABC transporter signature motif; other site 632516002920 Walker B; other site 632516002921 D-loop; other site 632516002922 H-loop/switch region; other site 632516002923 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632516002924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516002925 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 632516002926 Walker A/P-loop; other site 632516002927 ATP binding site [chemical binding]; other site 632516002928 Q-loop/lid; other site 632516002929 ABC transporter signature motif; other site 632516002930 Walker B; other site 632516002931 D-loop; other site 632516002932 H-loop/switch region; other site 632516002933 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 632516002934 core dimer interface [polypeptide binding]; other site 632516002935 peripheral dimer interface [polypeptide binding]; other site 632516002936 L10 interface [polypeptide binding]; other site 632516002937 L11 interface [polypeptide binding]; other site 632516002938 putative EF-Tu interaction site [polypeptide binding]; other site 632516002939 putative EF-G interaction site [polypeptide binding]; other site 632516002940 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 632516002941 23S rRNA interface [nucleotide binding]; other site 632516002942 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 632516002943 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 632516002944 mRNA/rRNA interface [nucleotide binding]; other site 632516002945 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 632516002946 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 632516002947 23S rRNA interface [nucleotide binding]; other site 632516002948 L7/L12 interface [polypeptide binding]; other site 632516002949 putative thiostrepton binding site; other site 632516002950 L25 interface [polypeptide binding]; other site 632516002951 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 632516002952 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 632516002953 putative homodimer interface [polypeptide binding]; other site 632516002954 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 632516002955 heterodimer interface [polypeptide binding]; other site 632516002956 homodimer interface [polypeptide binding]; other site 632516002957 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 632516002958 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 632516002959 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 632516002960 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 632516002961 active site 632516002962 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632516002963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632516002964 DNA-binding site [nucleotide binding]; DNA binding site 632516002965 FCD domain; Region: FCD; pfam07729 632516002966 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 632516002967 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632516002968 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632516002969 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 632516002970 active site 632516002971 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 632516002972 dimer interface [polypeptide binding]; other site 632516002973 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 632516002974 Ligand Binding Site [chemical binding]; other site 632516002975 Molecular Tunnel; other site 632516002976 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 632516002977 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 632516002978 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 632516002979 catalytic site [active] 632516002980 subunit interface [polypeptide binding]; other site 632516002981 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 632516002982 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632516002983 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 632516002984 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 632516002985 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632516002986 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632516002987 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 632516002988 ornithine carbamoyltransferase; Provisional; Region: PRK00779 632516002989 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 632516002990 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 632516002991 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 632516002992 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 632516002993 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 632516002994 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632516002995 RNA binding surface [nucleotide binding]; other site 632516002996 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 632516002997 active site 632516002998 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 632516002999 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 632516003000 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 632516003001 Ligand Binding Site [chemical binding]; other site 632516003002 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 632516003003 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 632516003004 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632516003005 catalytic residue [active] 632516003006 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 632516003007 RNA methyltransferase, RsmE family; Region: TIGR00046 632516003008 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 632516003009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516003010 S-adenosylmethionine binding site [chemical binding]; other site 632516003011 chaperone protein DnaJ; Provisional; Region: PRK14277 632516003012 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632516003013 HSP70 interaction site [polypeptide binding]; other site 632516003014 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 632516003015 substrate binding site [polypeptide binding]; other site 632516003016 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 632516003017 Zn binding sites [ion binding]; other site 632516003018 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 632516003019 dimer interface [polypeptide binding]; other site 632516003020 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 632516003021 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 632516003022 nucleotide binding site [chemical binding]; other site 632516003023 NEF interaction site [polypeptide binding]; other site 632516003024 SBD interface [polypeptide binding]; other site 632516003025 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 632516003026 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 632516003027 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 632516003028 dimer interface [polypeptide binding]; other site 632516003029 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 632516003030 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 632516003031 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 632516003032 clostripain; Region: clostrip; TIGR02806 632516003033 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 632516003034 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516003035 FeS/SAM binding site; other site 632516003036 HemN C-terminal domain; Region: HemN_C; pfam06969 632516003037 GTP-binding protein LepA; Provisional; Region: PRK05433 632516003038 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 632516003039 G1 box; other site 632516003040 putative GEF interaction site [polypeptide binding]; other site 632516003041 GTP/Mg2+ binding site [chemical binding]; other site 632516003042 Switch I region; other site 632516003043 G2 box; other site 632516003044 G3 box; other site 632516003045 Switch II region; other site 632516003046 G4 box; other site 632516003047 G5 box; other site 632516003048 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 632516003049 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 632516003050 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 632516003051 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 632516003052 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 632516003053 putative active site [active] 632516003054 putative metal binding site [ion binding]; other site 632516003055 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632516003056 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 632516003057 active site 632516003058 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 632516003059 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516003060 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516003061 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 632516003062 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 632516003063 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 632516003064 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 632516003065 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 632516003066 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 632516003067 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 632516003068 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632516003069 metal binding site 2 [ion binding]; metal-binding site 632516003070 putative DNA binding helix; other site 632516003071 metal binding site 1 [ion binding]; metal-binding site 632516003072 dimer interface [polypeptide binding]; other site 632516003073 structural Zn2+ binding site [ion binding]; other site 632516003074 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 632516003075 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 632516003076 G1 box; other site 632516003077 GTP/Mg2+ binding site [chemical binding]; other site 632516003078 G2 box; other site 632516003079 Switch I region; other site 632516003080 G3 box; other site 632516003081 Switch II region; other site 632516003082 G4 box; other site 632516003083 G5 box; other site 632516003084 Nucleoside recognition; Region: Gate; pfam07670 632516003085 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 632516003086 Nucleoside recognition; Region: Gate; pfam07670 632516003087 FeoA domain; Region: FeoA; pfam04023 632516003088 Flavin Reductases; Region: FlaRed; cl00801 632516003089 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 632516003090 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632516003091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516003092 Walker A/P-loop; other site 632516003093 ATP binding site [chemical binding]; other site 632516003094 Q-loop/lid; other site 632516003095 ABC transporter signature motif; other site 632516003096 Walker B; other site 632516003097 D-loop; other site 632516003098 H-loop/switch region; other site 632516003099 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 632516003100 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 632516003101 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 632516003102 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 632516003103 HlyD family secretion protein; Region: HlyD_3; pfam13437 632516003104 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 632516003105 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 632516003106 putative active site [active] 632516003107 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516003108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516003109 Walker A/P-loop; other site 632516003110 ATP binding site [chemical binding]; other site 632516003111 Q-loop/lid; other site 632516003112 ABC transporter signature motif; other site 632516003113 Walker B; other site 632516003114 D-loop; other site 632516003115 H-loop/switch region; other site 632516003116 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 632516003117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632516003118 binding surface 632516003119 TPR motif; other site 632516003120 TPR repeat; Region: TPR_11; pfam13414 632516003121 TPR repeat; Region: TPR_11; pfam13414 632516003122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632516003123 TPR motif; other site 632516003124 binding surface 632516003125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516003126 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632516003127 Walker A motif; other site 632516003128 ATP binding site [chemical binding]; other site 632516003129 Walker B motif; other site 632516003130 arginine finger; other site 632516003131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632516003132 TPR motif; other site 632516003133 TPR repeat; Region: TPR_11; pfam13414 632516003134 binding surface 632516003135 TPR repeat; Region: TPR_11; pfam13414 632516003136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 632516003137 TPR motif; other site 632516003138 binding surface 632516003139 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 632516003140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516003141 Walker A motif; other site 632516003142 ATP binding site [chemical binding]; other site 632516003143 Walker B motif; other site 632516003144 arginine finger; other site 632516003145 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 632516003146 Uncharacterized conserved protein [Function unknown]; Region: COG1479 632516003147 Protein of unknown function DUF262; Region: DUF262; pfam03235 632516003148 Uncharacterized conserved protein [Function unknown]; Region: COG3472 632516003149 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 632516003150 PLD-like domain; Region: PLDc_2; pfam13091 632516003151 putative active site [active] 632516003152 catalytic site [active] 632516003153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516003154 ATP binding site [chemical binding]; other site 632516003155 putative Mg++ binding site [ion binding]; other site 632516003156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632516003157 nucleotide binding region [chemical binding]; other site 632516003158 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 632516003159 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 632516003160 Protein of unknown function (DUF3780); Region: DUF3780; pfam12635 632516003161 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 632516003162 Protein of unknown function (DUF499); Region: DUF499; pfam04465 632516003163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516003164 AAA ATPase domain; Region: AAA_15; pfam13175 632516003165 Walker A/P-loop; other site 632516003166 ATP binding site [chemical binding]; other site 632516003167 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 632516003168 putative active site [active] 632516003169 putative metal-binding site [ion binding]; other site 632516003170 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 632516003171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516003172 ATP binding site [chemical binding]; other site 632516003173 putative Mg++ binding site [ion binding]; other site 632516003174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632516003175 nucleotide binding region [chemical binding]; other site 632516003176 ATP-binding site [chemical binding]; other site 632516003177 Nuclease-related domain; Region: NERD; pfam08378 632516003178 Peptidase family M48; Region: Peptidase_M48; cl12018 632516003179 KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878 632516003180 KaiC; Region: KaiC; pfam06745 632516003181 Walker A motif; other site 632516003182 ATP binding site [chemical binding]; other site 632516003183 Walker B motif; other site 632516003184 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 632516003185 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 632516003186 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632516003187 dimer interface [polypeptide binding]; other site 632516003188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516003189 catalytic residue [active] 632516003190 Uncharacterized conserved protein [Function unknown]; Region: COG3937 632516003191 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 632516003192 ABC1 family; Region: ABC1; cl17513 632516003193 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 632516003194 active site 632516003195 ATP binding site [chemical binding]; other site 632516003196 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 632516003197 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 632516003198 nucleotide binding pocket [chemical binding]; other site 632516003199 K-X-D-G motif; other site 632516003200 catalytic site [active] 632516003201 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 632516003202 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 632516003203 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 632516003204 Dimer interface [polypeptide binding]; other site 632516003205 BRCT sequence motif; other site 632516003206 Uncharacterized conserved protein [Function unknown]; Region: COG0327 632516003207 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 632516003208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 632516003209 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 632516003210 Family of unknown function (DUF633); Region: DUF633; pfam04816 632516003211 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 632516003212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516003213 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 632516003214 Transposase domain (DUF772); Region: DUF772; pfam05598 632516003215 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632516003216 putative homodimer interface [polypeptide binding]; other site 632516003217 putative homotetramer interface [polypeptide binding]; other site 632516003218 putative allosteric switch controlling residues; other site 632516003219 putative metal binding site [ion binding]; other site 632516003220 putative homodimer-homodimer interface [polypeptide binding]; other site 632516003221 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 632516003222 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 632516003223 catalytic residues [active] 632516003224 Uncharacterized conserved protein [Function unknown]; Region: COG2968 632516003225 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 632516003226 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 632516003227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516003228 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632516003229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516003230 Predicted membrane protein [Function unknown]; Region: COG2510 632516003231 Heme NO binding; Region: HNOB; pfam07700 632516003232 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632516003233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632516003234 dimer interface [polypeptide binding]; other site 632516003235 putative CheW interface [polypeptide binding]; other site 632516003236 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 632516003237 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 632516003238 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632516003239 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632516003240 catalytic residue [active] 632516003241 GTP-binding protein YchF; Reviewed; Region: PRK09601 632516003242 YchF GTPase; Region: YchF; cd01900 632516003243 G1 box; other site 632516003244 GTP/Mg2+ binding site [chemical binding]; other site 632516003245 Switch I region; other site 632516003246 G2 box; other site 632516003247 Switch II region; other site 632516003248 G3 box; other site 632516003249 G4 box; other site 632516003250 G5 box; other site 632516003251 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 632516003252 Protein of unknown function DUF111; Region: DUF111; pfam01969 632516003253 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 632516003254 AIR carboxylase; Region: AIRC; smart01001 632516003255 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 632516003256 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 632516003257 Ligand Binding Site [chemical binding]; other site 632516003258 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 632516003259 active site 632516003260 catalytic residues [active] 632516003261 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 632516003262 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632516003263 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 632516003264 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 632516003265 active site 632516003266 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 632516003267 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 632516003268 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 632516003269 Catalytic site [active] 632516003270 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 632516003271 MutS domain III; Region: MutS_III; pfam05192 632516003272 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 632516003273 Walker A/P-loop; other site 632516003274 ATP binding site [chemical binding]; other site 632516003275 Q-loop/lid; other site 632516003276 ABC transporter signature motif; other site 632516003277 Walker B; other site 632516003278 D-loop; other site 632516003279 H-loop/switch region; other site 632516003280 Smr domain; Region: Smr; pfam01713 632516003281 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 632516003282 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 632516003283 putative catalytic cysteine [active] 632516003284 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 632516003285 gamma-glutamyl kinase; Provisional; Region: PRK05429 632516003286 nucleotide binding site [chemical binding]; other site 632516003287 homotetrameric interface [polypeptide binding]; other site 632516003288 putative phosphate binding site [ion binding]; other site 632516003289 putative allosteric binding site; other site 632516003290 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 632516003291 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 632516003292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632516003293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516003294 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 632516003295 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 632516003296 FlgN protein; Region: FlgN; pfam05130 632516003297 Flagellar protein FliS; Region: FliS; cl00654 632516003298 flagellar capping protein; Validated; Region: fliD; PRK07737 632516003299 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 632516003300 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 632516003301 FlaG protein; Region: FlaG; pfam03646 632516003302 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 632516003303 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516003304 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 632516003305 DNA binding residues [nucleotide binding] 632516003306 Protein of unknown function, DUF488; Region: DUF488; pfam04343 632516003307 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 632516003308 DNA methylase; Region: N6_N4_Mtase; pfam01555 632516003309 EcoRII C terminal; Region: EcoRII-C; pfam09019 632516003310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 632516003311 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 632516003312 ligand binding site; other site 632516003313 tetramer interface; other site 632516003314 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 632516003315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516003316 motif I; other site 632516003317 active site 632516003318 NeuB family; Region: NeuB; pfam03102 632516003319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 632516003320 flagellin; Provisional; Region: PRK12804 632516003321 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 632516003322 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 632516003323 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 632516003324 AAA domain; Region: AAA_14; pfam13173 632516003325 Global regulator protein family; Region: CsrA; pfam02599 632516003326 flagellar assembly protein FliW; Provisional; Region: PRK13285 632516003327 Uncharacterized conserved protein [Function unknown]; Region: COG2445 632516003328 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632516003329 active site 632516003330 NTP binding site [chemical binding]; other site 632516003331 metal binding triad [ion binding]; metal-binding site 632516003332 antibiotic binding site [chemical binding]; other site 632516003333 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 632516003334 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 632516003335 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 632516003336 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 632516003337 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 632516003338 FlgN protein; Region: FlgN; pfam05130 632516003339 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 632516003340 flagellar operon protein TIGR03826; Region: YvyF 632516003341 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 632516003342 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516003343 active site 632516003344 sporulation sigma factor SigF; Validated; Region: PRK05572 632516003345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516003346 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632516003347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632516003348 DNA binding residues [nucleotide binding] 632516003349 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 632516003350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516003351 ATP binding site [chemical binding]; other site 632516003352 Mg2+ binding site [ion binding]; other site 632516003353 G-X-G motif; other site 632516003354 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632516003355 anti sigma factor interaction site; other site 632516003356 regulatory phosphorylation site [posttranslational modification]; other site 632516003357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632516003358 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632516003359 Integrase core domain; Region: rve; pfam00665 632516003360 Uncharacterized conserved protein [Function unknown]; Region: COG1434 632516003361 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 632516003362 putative active site [active] 632516003363 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 632516003364 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 632516003365 dimerization interface 3.5A [polypeptide binding]; other site 632516003366 active site 632516003367 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 632516003368 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 632516003369 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632516003370 Walker A/P-loop; other site 632516003371 ATP binding site [chemical binding]; other site 632516003372 Q-loop/lid; other site 632516003373 ABC transporter signature motif; other site 632516003374 Walker B; other site 632516003375 D-loop; other site 632516003376 H-loop/switch region; other site 632516003377 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 632516003378 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632516003379 Walker A/P-loop; other site 632516003380 ATP binding site [chemical binding]; other site 632516003381 Q-loop/lid; other site 632516003382 ABC transporter signature motif; other site 632516003383 Walker B; other site 632516003384 D-loop; other site 632516003385 H-loop/switch region; other site 632516003386 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 632516003387 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 632516003388 substrate binding site [chemical binding]; other site 632516003389 active site 632516003390 catalytic residues [active] 632516003391 heterodimer interface [polypeptide binding]; other site 632516003392 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 632516003393 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 632516003394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516003395 catalytic residue [active] 632516003396 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 632516003397 active site 632516003398 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 632516003399 active site 632516003400 ribulose/triose binding site [chemical binding]; other site 632516003401 phosphate binding site [ion binding]; other site 632516003402 substrate (anthranilate) binding pocket [chemical binding]; other site 632516003403 product (indole) binding pocket [chemical binding]; other site 632516003404 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 632516003405 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 632516003406 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 632516003407 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 632516003408 Glutamine amidotransferase class-I; Region: GATase; pfam00117 632516003409 glutamine binding [chemical binding]; other site 632516003410 catalytic triad [active] 632516003411 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 632516003412 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 632516003413 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 632516003414 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 632516003415 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 632516003416 active site 632516003417 Dehydroquinase class II; Region: DHquinase_II; pfam01220 632516003418 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 632516003419 trimer interface [polypeptide binding]; other site 632516003420 active site 632516003421 dimer interface [polypeptide binding]; other site 632516003422 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 632516003423 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632516003424 Metal-binding active site; metal-binding site 632516003425 AP (apurinic/apyrimidinic) site pocket; other site 632516003426 shikimate kinase; Reviewed; Region: aroK; PRK00131 632516003427 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 632516003428 ADP binding site [chemical binding]; other site 632516003429 magnesium binding site [ion binding]; other site 632516003430 putative shikimate binding site; other site 632516003431 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 632516003432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516003433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632516003434 DNA binding residues [nucleotide binding] 632516003435 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 632516003436 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632516003437 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632516003438 Walker A/P-loop; other site 632516003439 ATP binding site [chemical binding]; other site 632516003440 Q-loop/lid; other site 632516003441 ABC transporter signature motif; other site 632516003442 Walker B; other site 632516003443 D-loop; other site 632516003444 H-loop/switch region; other site 632516003445 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 632516003446 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 632516003447 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 632516003448 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632516003449 dimer interface [polypeptide binding]; other site 632516003450 PYR/PP interface [polypeptide binding]; other site 632516003451 TPP binding site [chemical binding]; other site 632516003452 substrate binding site [chemical binding]; other site 632516003453 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632516003454 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 632516003455 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 632516003456 TPP-binding site [chemical binding]; other site 632516003457 putative dimer interface [polypeptide binding]; other site 632516003458 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 632516003459 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 632516003460 4Fe-4S binding domain; Region: Fer4_6; pfam12837 632516003461 4Fe-4S binding domain; Region: Fer4; pfam00037 632516003462 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 632516003463 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 632516003464 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 632516003465 active site 632516003466 NTP binding site [chemical binding]; other site 632516003467 metal binding triad [ion binding]; metal-binding site 632516003468 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 632516003469 histidinol-phosphatase; Provisional; Region: PRK05588 632516003470 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632516003471 active site 632516003472 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 632516003473 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 632516003474 Ligand Binding Site [chemical binding]; other site 632516003475 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 632516003476 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 632516003477 trimerization site [polypeptide binding]; other site 632516003478 active site 632516003479 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 632516003480 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 632516003481 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632516003482 catalytic residue [active] 632516003483 Transcriptional regulator; Region: Rrf2; cl17282 632516003484 Rrf2 family protein; Region: rrf2_super; TIGR00738 632516003485 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 632516003486 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 632516003487 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 632516003488 alphaNTD homodimer interface [polypeptide binding]; other site 632516003489 alphaNTD - beta interaction site [polypeptide binding]; other site 632516003490 alphaNTD - beta' interaction site [polypeptide binding]; other site 632516003491 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 632516003492 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 632516003493 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 632516003494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632516003495 RNA binding surface [nucleotide binding]; other site 632516003496 30S ribosomal protein S11; Validated; Region: PRK05309 632516003497 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 632516003498 30S ribosomal protein S13; Region: bact_S13; TIGR03631 632516003499 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 632516003500 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 632516003501 rRNA binding site [nucleotide binding]; other site 632516003502 predicted 30S ribosome binding site; other site 632516003503 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 632516003504 RNA binding site [nucleotide binding]; other site 632516003505 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 632516003506 active site 632516003507 adenylate kinase; Reviewed; Region: adk; PRK00279 632516003508 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 632516003509 AMP-binding site [chemical binding]; other site 632516003510 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 632516003511 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 632516003512 SecY translocase; Region: SecY; pfam00344 632516003513 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 632516003514 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 632516003515 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 632516003516 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 632516003517 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 632516003518 23S rRNA interface [nucleotide binding]; other site 632516003519 5S rRNA interface [nucleotide binding]; other site 632516003520 L27 interface [polypeptide binding]; other site 632516003521 L5 interface [polypeptide binding]; other site 632516003522 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 632516003523 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 632516003524 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 632516003525 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 632516003526 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 632516003527 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 632516003528 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 632516003529 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 632516003530 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 632516003531 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 632516003532 RNA binding site [nucleotide binding]; other site 632516003533 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 632516003534 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 632516003535 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 632516003536 23S rRNA interface [nucleotide binding]; other site 632516003537 putative translocon interaction site; other site 632516003538 signal recognition particle (SRP54) interaction site; other site 632516003539 L23 interface [polypeptide binding]; other site 632516003540 trigger factor interaction site; other site 632516003541 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 632516003542 23S rRNA interface [nucleotide binding]; other site 632516003543 5S rRNA interface [nucleotide binding]; other site 632516003544 putative antibiotic binding site [chemical binding]; other site 632516003545 L25 interface [polypeptide binding]; other site 632516003546 L27 interface [polypeptide binding]; other site 632516003547 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 632516003548 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 632516003549 G-X-X-G motif; other site 632516003550 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 632516003551 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 632516003552 putative translocon binding site; other site 632516003553 protein-rRNA interface [nucleotide binding]; other site 632516003554 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 632516003555 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 632516003556 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 632516003557 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 632516003558 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 632516003559 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 632516003560 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 632516003561 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 632516003562 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 632516003563 iron binding site [ion binding]; other site 632516003564 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 632516003565 Ferritin-like domain; Region: Ferritin; pfam00210 632516003566 dinuclear metal binding motif [ion binding]; other site 632516003567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632516003568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632516003569 dimerization interface [polypeptide binding]; other site 632516003570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632516003571 dimer interface [polypeptide binding]; other site 632516003572 phosphorylation site [posttranslational modification] 632516003573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516003574 ATP binding site [chemical binding]; other site 632516003575 Mg2+ binding site [ion binding]; other site 632516003576 G-X-G motif; other site 632516003577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632516003578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516003579 active site 632516003580 phosphorylation site [posttranslational modification] 632516003581 intermolecular recognition site; other site 632516003582 dimerization interface [polypeptide binding]; other site 632516003583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632516003584 DNA binding site [nucleotide binding] 632516003585 RRXRR protein; Region: RRXRR; pfam14239 632516003586 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632516003587 active site 632516003588 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 632516003589 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 632516003590 active site 632516003591 substrate binding site [chemical binding]; other site 632516003592 metal binding site [ion binding]; metal-binding site 632516003593 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 632516003594 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 632516003595 oligomer interface [polypeptide binding]; other site 632516003596 putative active site [active] 632516003597 metal binding site [ion binding]; metal-binding site 632516003598 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 632516003599 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 632516003600 B12 binding domain; Region: B12-binding; pfam02310 632516003601 B12 binding site [chemical binding]; other site 632516003602 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 632516003603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516003604 FeS/SAM binding site; other site 632516003605 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 632516003606 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 632516003607 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 632516003608 CPxP motif; other site 632516003609 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632516003610 putative homodimer interface [polypeptide binding]; other site 632516003611 putative homotetramer interface [polypeptide binding]; other site 632516003612 putative allosteric switch controlling residues; other site 632516003613 putative metal binding site [ion binding]; other site 632516003614 putative homodimer-homodimer interface [polypeptide binding]; other site 632516003615 4Fe-4S binding domain; Region: Fer4; cl02805 632516003616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516003617 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516003618 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516003619 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 632516003620 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632516003621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632516003622 DNA-binding site [nucleotide binding]; DNA binding site 632516003623 FCD domain; Region: FCD; pfam07729 632516003624 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 632516003625 isocitrate dehydrogenase; Validated; Region: PRK06451 632516003626 aconitate hydratase; Validated; Region: PRK07229 632516003627 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 632516003628 substrate binding site [chemical binding]; other site 632516003629 ligand binding site [chemical binding]; other site 632516003630 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 632516003631 substrate binding site [chemical binding]; other site 632516003632 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 632516003633 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 632516003634 putative ligand binding site [chemical binding]; other site 632516003635 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 632516003636 active site 632516003637 catalytic residues [active] 632516003638 metal binding site [ion binding]; metal-binding site 632516003639 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 632516003640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516003641 dimer interface [polypeptide binding]; other site 632516003642 conserved gate region; other site 632516003643 putative PBP binding loops; other site 632516003644 ABC-ATPase subunit interface; other site 632516003645 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632516003646 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 632516003647 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 632516003648 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632516003649 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 632516003650 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967 632516003651 Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia. This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965 632516003652 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 632516003653 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 632516003654 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967 632516003655 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 632516003656 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632516003657 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 632516003658 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632516003659 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 632516003660 nitrogenase iron protein; Region: nifH; TIGR01287 632516003661 Nucleotide-binding sites [chemical binding]; other site 632516003662 Walker A motif; other site 632516003663 Switch I region of nucleotide binding site; other site 632516003664 Fe4S4 binding sites [ion binding]; other site 632516003665 Switch II region of nucleotide binding site; other site 632516003666 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 632516003667 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632516003668 ammonium transporter; Region: amt; TIGR00836 632516003669 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516003670 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 632516003671 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 632516003672 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 632516003673 active site 632516003674 catalytic residues [active] 632516003675 metal binding site [ion binding]; metal-binding site 632516003676 RmuC family; Region: RmuC; pfam02646 632516003677 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 632516003678 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 632516003679 DNA polymerase III subunit delta'; Validated; Region: PRK08485 632516003680 Protein of unknown function (DUF327); Region: DUF327; pfam03885 632516003681 Protein of unknown function (DUF970); Region: DUF970; pfam06153 632516003682 thymidylate kinase; Validated; Region: tmk; PRK00698 632516003683 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 632516003684 TMP-binding site; other site 632516003685 ATP-binding site [chemical binding]; other site 632516003686 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 632516003687 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632516003688 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632516003689 catalytic residue [active] 632516003690 Fumarase C-terminus; Region: Fumerase_C; pfam05683 632516003691 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632516003692 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632516003693 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 632516003694 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 632516003695 active site 632516003696 catalytic residues [active] 632516003697 metal binding site [ion binding]; metal-binding site 632516003698 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 632516003699 2-isopropylmalate synthase; Validated; Region: PRK00915 632516003700 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 632516003701 active site 632516003702 catalytic residues [active] 632516003703 metal binding site [ion binding]; metal-binding site 632516003704 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 632516003705 ketol-acid reductoisomerase; Provisional; Region: PRK05479 632516003706 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 632516003707 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 632516003708 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 632516003709 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 632516003710 putative valine binding site [chemical binding]; other site 632516003711 dimer interface [polypeptide binding]; other site 632516003712 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 632516003713 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 632516003714 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632516003715 PYR/PP interface [polypeptide binding]; other site 632516003716 dimer interface [polypeptide binding]; other site 632516003717 TPP binding site [chemical binding]; other site 632516003718 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632516003719 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 632516003720 TPP-binding site [chemical binding]; other site 632516003721 dimer interface [polypeptide binding]; other site 632516003722 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 632516003723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632516003724 NAD(P) binding site [chemical binding]; other site 632516003725 active site 632516003726 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 632516003727 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 632516003728 active site 632516003729 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632516003730 Transposase domain (DUF772); Region: DUF772; pfam05598 632516003731 Uncharacterized conserved protein [Function unknown]; Region: COG1633 632516003732 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 632516003733 diiron binding motif [ion binding]; other site 632516003734 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 632516003735 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 632516003736 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 632516003737 Transposase domain (DUF772); Region: DUF772; pfam05598 632516003738 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 632516003739 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 632516003740 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 632516003741 Aspartase; Region: Aspartase; cd01357 632516003742 active sites [active] 632516003743 tetramer interface [polypeptide binding]; other site 632516003744 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 632516003745 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 632516003746 G1 box; other site 632516003747 GTP/Mg2+ binding site [chemical binding]; other site 632516003748 Switch I region; other site 632516003749 G2 box; other site 632516003750 Switch II region; other site 632516003751 G3 box; other site 632516003752 G4 box; other site 632516003753 G5 box; other site 632516003754 Uncharacterized conserved protein [Function unknown]; Region: COG2968 632516003755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 632516003756 Predicted acetyltransferase [General function prediction only]; Region: COG3393 632516003757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632516003758 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 632516003759 Melibiase; Region: Melibiase; pfam02065 632516003760 CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881 632516003761 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632516003762 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516003763 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 632516003764 Walker A/P-loop; other site 632516003765 ATP binding site [chemical binding]; other site 632516003766 Q-loop/lid; other site 632516003767 ABC transporter signature motif; other site 632516003768 Walker B; other site 632516003769 D-loop; other site 632516003770 H-loop/switch region; other site 632516003771 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 632516003772 Pectate lyase; Region: Pectate_lyase; pfam03211 632516003773 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 632516003774 Cellulose binding domain; Region: CBM_3; cl03026 632516003775 Cellulose binding domain; Region: CBM_3; cl03026 632516003776 Right handed beta helix region; Region: Beta_helix; pfam13229 632516003777 Helix-turn-helix domain; Region: HTH_18; pfam12833 632516003778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516003779 mannonate dehydratase; Provisional; Region: PRK03906 632516003780 mannonate dehydratase; Region: uxuA; TIGR00695 632516003781 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 632516003782 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 632516003783 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 632516003784 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 632516003785 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 632516003786 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 632516003787 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 632516003788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516003789 active site 632516003790 phosphorylation site [posttranslational modification] 632516003791 intermolecular recognition site; other site 632516003792 dimerization interface [polypeptide binding]; other site 632516003793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516003794 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 632516003795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632516003796 dimerization interface [polypeptide binding]; other site 632516003797 Histidine kinase; Region: His_kinase; pfam06580 632516003798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516003799 ATP binding site [chemical binding]; other site 632516003800 Mg2+ binding site [ion binding]; other site 632516003801 G-X-G motif; other site 632516003802 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516003803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516003804 dimer interface [polypeptide binding]; other site 632516003805 ABC-ATPase subunit interface; other site 632516003806 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632516003807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516003808 dimer interface [polypeptide binding]; other site 632516003809 conserved gate region; other site 632516003810 ABC-ATPase subunit interface; other site 632516003811 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632516003812 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516003813 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 632516003814 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632516003815 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516003816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632516003817 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632516003818 Integrase core domain; Region: rve; pfam00665 632516003819 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 632516003820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632516003821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516003822 homodimer interface [polypeptide binding]; other site 632516003823 catalytic residue [active] 632516003824 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 632516003825 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 632516003826 prephenate dehydrogenase; Validated; Region: PRK08507 632516003827 Prephenate dehydrogenase; Region: PDH; pfam02153 632516003828 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 632516003829 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 632516003830 hinge; other site 632516003831 active site 632516003832 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632516003833 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 632516003834 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632516003835 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632516003836 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 632516003837 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 632516003838 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632516003839 active site 632516003840 metal binding site [ion binding]; metal-binding site 632516003841 homotetramer interface [polypeptide binding]; other site 632516003842 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 632516003843 active site 632516003844 dimerization interface [polypeptide binding]; other site 632516003845 ribonuclease PH; Reviewed; Region: rph; PRK00173 632516003846 Ribonuclease PH; Region: RNase_PH_bact; cd11362 632516003847 hexamer interface [polypeptide binding]; other site 632516003848 active site 632516003849 Sporulation and spore germination; Region: Germane; pfam10646 632516003850 Sporulation and spore germination; Region: Germane; cl11253 632516003851 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 632516003852 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 632516003853 Mg++ binding site [ion binding]; other site 632516003854 putative catalytic motif [active] 632516003855 substrate binding site [chemical binding]; other site 632516003856 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 632516003857 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 632516003858 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 632516003859 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 632516003860 Coenzyme A binding pocket [chemical binding]; other site 632516003861 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 632516003862 MPT binding site; other site 632516003863 trimer interface [polypeptide binding]; other site 632516003864 molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499 632516003865 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 632516003866 trimer interface [polypeptide binding]; other site 632516003867 dimer interface [polypeptide binding]; other site 632516003868 putative active site [active] 632516003869 MOSC domain; Region: MOSC; pfam03473 632516003870 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 632516003871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 632516003872 FeS/SAM binding site; other site 632516003873 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 632516003874 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 632516003875 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 632516003876 dimer interface [polypeptide binding]; other site 632516003877 putative functional site; other site 632516003878 putative MPT binding site; other site 632516003879 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 632516003880 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 632516003881 dimer interface [polypeptide binding]; other site 632516003882 putative functional site; other site 632516003883 putative MPT binding site; other site 632516003884 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632516003885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516003886 Walker A/P-loop; other site 632516003887 ATP binding site [chemical binding]; other site 632516003888 Q-loop/lid; other site 632516003889 ABC transporter signature motif; other site 632516003890 Walker B; other site 632516003891 D-loop; other site 632516003892 H-loop/switch region; other site 632516003893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516003894 dimer interface [polypeptide binding]; other site 632516003895 conserved gate region; other site 632516003896 putative PBP binding loops; other site 632516003897 ABC-ATPase subunit interface; other site 632516003898 PBP superfamily domain; Region: PBP_like_2; pfam12849 632516003899 hypothetical protein; Provisional; Region: PRK08328 632516003900 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 632516003901 ATP binding site [chemical binding]; other site 632516003902 substrate interface [chemical binding]; other site 632516003903 ThiS family; Region: ThiS; pfam02597 632516003904 charged pocket; other site 632516003905 hydrophobic patch; other site 632516003906 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 632516003907 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 632516003908 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 632516003909 NADH dehydrogenase subunit I; Region: ndhI; CHL00014 632516003910 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516003911 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 632516003912 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 632516003913 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632516003914 hypothetical protein; Validated; Region: PRK00110 632516003915 stage V sporulation protein B; Region: spore_V_B; TIGR02900 632516003916 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 632516003917 Uncharacterized conserved protein [Function unknown]; Region: COG1739 632516003918 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 632516003919 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 632516003920 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 632516003921 active site 632516003922 Ap6A binding site [chemical binding]; other site 632516003923 nudix motif; other site 632516003924 metal binding site [ion binding]; metal-binding site 632516003925 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 632516003926 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 632516003927 HflX GTPase family; Region: HflX; cd01878 632516003928 G1 box; other site 632516003929 GTP/Mg2+ binding site [chemical binding]; other site 632516003930 Switch I region; other site 632516003931 G2 box; other site 632516003932 G3 box; other site 632516003933 Switch II region; other site 632516003934 G4 box; other site 632516003935 G5 box; other site 632516003936 elongation factor Tu; Reviewed; Region: PRK00049 632516003937 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 632516003938 G1 box; other site 632516003939 GEF interaction site [polypeptide binding]; other site 632516003940 GTP/Mg2+ binding site [chemical binding]; other site 632516003941 Switch I region; other site 632516003942 G2 box; other site 632516003943 G3 box; other site 632516003944 Switch II region; other site 632516003945 G4 box; other site 632516003946 G5 box; other site 632516003947 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 632516003948 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 632516003949 Antibiotic Binding Site [chemical binding]; other site 632516003950 elongation factor G; Reviewed; Region: PRK00007 632516003951 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 632516003952 G1 box; other site 632516003953 putative GEF interaction site [polypeptide binding]; other site 632516003954 GTP/Mg2+ binding site [chemical binding]; other site 632516003955 Switch I region; other site 632516003956 G2 box; other site 632516003957 G3 box; other site 632516003958 Switch II region; other site 632516003959 G4 box; other site 632516003960 G5 box; other site 632516003961 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 632516003962 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 632516003963 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 632516003964 30S ribosomal protein S7; Validated; Region: PRK05302 632516003965 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 632516003966 S17 interaction site [polypeptide binding]; other site 632516003967 S8 interaction site; other site 632516003968 16S rRNA interaction site [nucleotide binding]; other site 632516003969 streptomycin interaction site [chemical binding]; other site 632516003970 23S rRNA interaction site [nucleotide binding]; other site 632516003971 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 632516003972 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 632516003973 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 632516003974 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 632516003975 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 632516003976 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 632516003977 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 632516003978 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 632516003979 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 632516003980 G-loop; other site 632516003981 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 632516003982 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 632516003983 DNA binding site [nucleotide binding] 632516003984 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 632516003985 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 632516003986 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 632516003987 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 632516003988 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 632516003989 RPB1 interaction site [polypeptide binding]; other site 632516003990 RPB10 interaction site [polypeptide binding]; other site 632516003991 RPB11 interaction site [polypeptide binding]; other site 632516003992 RPB3 interaction site [polypeptide binding]; other site 632516003993 RPB12 interaction site [polypeptide binding]; other site 632516003994 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 632516003995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516003996 active site 632516003997 phosphorylation site [posttranslational modification] 632516003998 intermolecular recognition site; other site 632516003999 dimerization interface [polypeptide binding]; other site 632516004000 CheB methylesterase; Region: CheB_methylest; pfam01339 632516004001 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 632516004002 active site 632516004003 metal binding site [ion binding]; metal-binding site 632516004004 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 632516004005 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 632516004006 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 632516004007 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 632516004008 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 632516004009 active site 632516004010 dimer interface [polypeptide binding]; other site 632516004011 motif 1; other site 632516004012 motif 2; other site 632516004013 motif 3; other site 632516004014 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 632516004015 anticodon binding site; other site 632516004016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632516004017 binding surface 632516004018 TPR repeat; Region: TPR_11; pfam13414 632516004019 TPR motif; other site 632516004020 Tetratricopeptide repeat; Region: TPR_16; pfam13432 632516004021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632516004022 binding surface 632516004023 TPR repeat; Region: TPR_11; pfam13414 632516004024 TPR motif; other site 632516004025 Divergent AAA domain; Region: AAA_4; pfam04326 632516004026 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 632516004027 CHASE4 domain; Region: CHASE4; cl01308 632516004028 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632516004029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516004030 Zn2+ binding site [ion binding]; other site 632516004031 Mg2+ binding site [ion binding]; other site 632516004032 Peptidase family M23; Region: Peptidase_M23; pfam01551 632516004033 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 632516004034 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 632516004035 ScpA/B protein; Region: ScpA_ScpB; cl00598 632516004036 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 632516004037 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 632516004038 active site 632516004039 HIGH motif; other site 632516004040 dimer interface [polypeptide binding]; other site 632516004041 KMSKS motif; other site 632516004042 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 632516004043 Peptidase family M50; Region: Peptidase_M50; pfam02163 632516004044 active site 632516004045 putative substrate binding region [chemical binding]; other site 632516004046 diaminopimelate decarboxylase; Region: lysA; TIGR01048 632516004047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 632516004048 active site 632516004049 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632516004050 substrate binding site [chemical binding]; other site 632516004051 catalytic residues [active] 632516004052 dimer interface [polypeptide binding]; other site 632516004053 AMP-binding domain protein; Validated; Region: PRK08315 632516004054 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632516004055 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 632516004056 acyl-activating enzyme (AAE) consensus motif; other site 632516004057 putative AMP binding site [chemical binding]; other site 632516004058 putative active site [active] 632516004059 putative CoA binding site [chemical binding]; other site 632516004060 sporulation sigma factor SigG; Reviewed; Region: PRK08215 632516004061 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516004062 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632516004063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632516004064 DNA binding residues [nucleotide binding] 632516004065 sporulation sigma factor SigE; Reviewed; Region: PRK08301 632516004066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516004067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632516004068 DNA binding residues [nucleotide binding] 632516004069 Domain of unknown function (DUF303); Region: DUF303; pfam03629 632516004070 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 632516004071 Domain of unknown function (DUF303); Region: DUF303; pfam03629 632516004072 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 632516004073 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 632516004074 putative active site [active] 632516004075 putative metal binding site [ion binding]; other site 632516004076 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 632516004077 cell division protein FtsZ; Validated; Region: PRK09330 632516004078 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 632516004079 nucleotide binding site [chemical binding]; other site 632516004080 SulA interaction site; other site 632516004081 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 632516004082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 632516004083 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 632516004084 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 632516004085 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 632516004086 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632516004087 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632516004088 hinge; other site 632516004089 active site 632516004090 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 632516004091 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 632516004092 active site 632516004093 homodimer interface [polypeptide binding]; other site 632516004094 cell division protein FtsW; Region: ftsW; TIGR02614 632516004095 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 632516004096 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 632516004097 NAD binding site [chemical binding]; other site 632516004098 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632516004099 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632516004100 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 632516004101 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 632516004102 Mg++ binding site [ion binding]; other site 632516004103 putative catalytic motif [active] 632516004104 putative substrate binding site [chemical binding]; other site 632516004105 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 632516004106 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632516004107 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632516004108 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632516004109 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 632516004110 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632516004111 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632516004112 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632516004113 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 632516004114 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 632516004115 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632516004116 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632516004117 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 632516004118 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 632516004119 Cell division protein FtsL; Region: FtsL; cl11433 632516004120 MraW methylase family; Region: Methyltransf_5; pfam01795 632516004121 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 632516004122 cell division protein MraZ; Reviewed; Region: PRK00326 632516004123 MraZ protein; Region: MraZ; pfam02381 632516004124 MraZ protein; Region: MraZ; pfam02381 632516004125 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 632516004126 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 632516004127 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 632516004128 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632516004129 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 632516004130 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632516004131 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 632516004132 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632516004133 active site 632516004134 NTP binding site [chemical binding]; other site 632516004135 metal binding triad [ion binding]; metal-binding site 632516004136 antibiotic binding site [chemical binding]; other site 632516004137 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 632516004138 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 632516004139 GatB domain; Region: GatB_Yqey; smart00845 632516004140 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 632516004141 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 632516004142 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 632516004143 Transposase domain (DUF772); Region: DUF772; pfam05598 632516004144 RecX family; Region: RecX; cl00936 632516004145 recombinase A; Provisional; Region: recA; PRK09354 632516004146 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 632516004147 hexamer interface [polypeptide binding]; other site 632516004148 Walker A motif; other site 632516004149 ATP binding site [chemical binding]; other site 632516004150 Walker B motif; other site 632516004151 competence damage-inducible protein A; Provisional; Region: PRK00549 632516004152 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 632516004153 putative MPT binding site; other site 632516004154 Competence-damaged protein; Region: CinA; pfam02464 632516004155 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 632516004156 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 632516004157 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632516004158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516004159 FeS/SAM binding site; other site 632516004160 TRAM domain; Region: TRAM; pfam01938 632516004161 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 632516004162 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 632516004163 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 632516004164 homodimer interface [polypeptide binding]; other site 632516004165 NADP binding site [chemical binding]; other site 632516004166 substrate binding site [chemical binding]; other site 632516004167 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 632516004168 hypothetical protein; Provisional; Region: PRK00955 632516004169 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 632516004170 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 632516004171 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 632516004172 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 632516004173 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 632516004174 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 632516004175 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 632516004176 NAD(P) binding site [chemical binding]; other site 632516004177 hypothetical protein; Reviewed; Region: PRK12497 632516004178 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 632516004179 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 632516004180 RNA/DNA hybrid binding site [nucleotide binding]; other site 632516004181 active site 632516004182 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 632516004183 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 632516004184 GTP/Mg2+ binding site [chemical binding]; other site 632516004185 G4 box; other site 632516004186 G5 box; other site 632516004187 G1 box; other site 632516004188 Switch I region; other site 632516004189 G2 box; other site 632516004190 G3 box; other site 632516004191 Switch II region; other site 632516004192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516004193 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516004194 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516004195 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 632516004196 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 632516004197 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 632516004198 RimM N-terminal domain; Region: RimM; pfam01782 632516004199 PRC-barrel domain; Region: PRC; pfam05239 632516004200 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 632516004201 hypothetical protein; Provisional; Region: PRK00468 632516004202 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 632516004203 signal recognition particle protein; Provisional; Region: PRK10867 632516004204 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 632516004205 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 632516004206 P loop; other site 632516004207 GTP binding site [chemical binding]; other site 632516004208 Signal peptide binding domain; Region: SRP_SPB; pfam02978 632516004209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516004210 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516004211 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516004212 putative DNA-binding protein; Validated; Region: PRK00118 632516004213 YARHG domain; Region: YARHG; pfam13308 632516004214 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632516004215 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 632516004216 Walker A/P-loop; other site 632516004217 ATP binding site [chemical binding]; other site 632516004218 Q-loop/lid; other site 632516004219 ABC transporter signature motif; other site 632516004220 Walker B; other site 632516004221 D-loop; other site 632516004222 H-loop/switch region; other site 632516004223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632516004224 DNA-binding site [nucleotide binding]; DNA binding site 632516004225 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 632516004226 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 632516004227 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632516004228 active site 632516004229 HIGH motif; other site 632516004230 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632516004231 active site 632516004232 KMSKS motif; other site 632516004233 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 632516004234 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 632516004235 NAD binding site [chemical binding]; other site 632516004236 homodimer interface [polypeptide binding]; other site 632516004237 active site 632516004238 substrate binding site [chemical binding]; other site 632516004239 galactokinase; Provisional; Region: PRK05322 632516004240 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 632516004241 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632516004242 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632516004243 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 632516004244 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 632516004245 dimer interface [polypeptide binding]; other site 632516004246 active site 632516004247 Sensory domain found in PocR; Region: PocR; pfam10114 632516004248 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 632516004249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516004250 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632516004251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516004252 Uncharacterized conserved protein [Function unknown]; Region: COG1683 632516004253 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 632516004254 G1 box; other site 632516004255 GTP/Mg2+ binding site [chemical binding]; other site 632516004256 Switch I region; other site 632516004257 G2 box; other site 632516004258 G3 box; other site 632516004259 Switch II region; other site 632516004260 G4 box; other site 632516004261 G5 box; other site 632516004262 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 632516004263 Found in ATP-dependent protease La (LON); Region: LON; smart00464 632516004264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516004265 Walker A motif; other site 632516004266 ATP binding site [chemical binding]; other site 632516004267 Walker B motif; other site 632516004268 arginine finger; other site 632516004269 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 632516004270 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 632516004271 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 632516004272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632516004273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632516004274 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632516004275 Predicted dehydrogenase [General function prediction only]; Region: COG0579 632516004276 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 632516004277 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632516004278 1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181 632516004279 dimer interface [polypeptide binding]; other site 632516004280 active site 632516004281 metal binding site [ion binding]; metal-binding site 632516004282 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 632516004283 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 632516004284 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 632516004285 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632516004286 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632516004287 Walker A/P-loop; other site 632516004288 ATP binding site [chemical binding]; other site 632516004289 Q-loop/lid; other site 632516004290 ABC transporter signature motif; other site 632516004291 Walker B; other site 632516004292 D-loop; other site 632516004293 H-loop/switch region; other site 632516004294 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 632516004295 active site 632516004296 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 632516004297 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632516004298 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632516004299 protein binding site [polypeptide binding]; other site 632516004300 Haemagglutinin; Region: Hemagglutinin; pfam00509 632516004301 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 632516004302 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 632516004303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 632516004304 Trp repressor protein; Region: Trp_repressor; cl17266 632516004305 YtxC-like family; Region: YtxC; pfam08812 632516004306 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 632516004307 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 632516004308 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 632516004309 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 632516004310 putative binding surface; other site 632516004311 active site 632516004312 P2 response regulator binding domain; Region: P2; pfam07194 632516004313 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 632516004314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516004315 ATP binding site [chemical binding]; other site 632516004316 Mg2+ binding site [ion binding]; other site 632516004317 G-X-G motif; other site 632516004318 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632516004319 Response regulator receiver domain; Region: Response_reg; pfam00072 632516004320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516004321 active site 632516004322 phosphorylation site [posttranslational modification] 632516004323 intermolecular recognition site; other site 632516004324 dimerization interface [polypeptide binding]; other site 632516004325 purine nucleoside phosphorylase; Provisional; Region: PRK08202 632516004326 phosphopentomutase; Provisional; Region: PRK05362 632516004327 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 632516004328 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 632516004329 intersubunit interface [polypeptide binding]; other site 632516004330 active site 632516004331 catalytic residue [active] 632516004332 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 632516004333 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 632516004334 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 632516004335 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 632516004336 XapX domain; Region: XapX; TIGR03510 632516004337 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 632516004338 active site 632516004339 catalytic motif [active] 632516004340 Zn binding site [ion binding]; other site 632516004341 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 632516004342 catalytic triad [active] 632516004343 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632516004344 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 632516004345 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 632516004346 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 632516004347 active site 632516004348 Int/Topo IB signature motif; other site 632516004349 stage II sporulation protein P; Region: spore_II_P; TIGR02867 632516004350 germination protease; Provisional; Region: PRK12362 632516004351 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 632516004352 germination protein YpeB; Region: spore_YpeB; TIGR02889 632516004353 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 632516004354 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 632516004355 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632516004356 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632516004357 Peptidase family M23; Region: Peptidase_M23; pfam01551 632516004358 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632516004359 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 632516004360 C-terminal peptidase (prc); Region: prc; TIGR00225 632516004361 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 632516004362 protein binding site [polypeptide binding]; other site 632516004363 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 632516004364 Catalytic dyad [active] 632516004365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 632516004366 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632516004367 Peptidase family M23; Region: Peptidase_M23; pfam01551 632516004368 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 632516004369 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 632516004370 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 632516004371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516004372 Walker A/P-loop; other site 632516004373 ATP binding site [chemical binding]; other site 632516004374 Q-loop/lid; other site 632516004375 ABC transporter signature motif; other site 632516004376 Walker B; other site 632516004377 D-loop; other site 632516004378 H-loop/switch region; other site 632516004379 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 632516004380 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632516004381 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632516004382 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 632516004383 Walker A/P-loop; other site 632516004384 ATP binding site [chemical binding]; other site 632516004385 Q-loop/lid; other site 632516004386 ABC transporter signature motif; other site 632516004387 Walker B; other site 632516004388 D-loop; other site 632516004389 H-loop/switch region; other site 632516004390 TOBE domain; Region: TOBE; pfam03459 632516004391 Predicted membrane protein [Function unknown]; Region: COG2261 632516004392 Thiamine pyrophosphokinase; Region: TPK; cd07995 632516004393 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 632516004394 active site 632516004395 dimerization interface [polypeptide binding]; other site 632516004396 thiamine binding site [chemical binding]; other site 632516004397 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 632516004398 DNA polymerase III PolC; Validated; Region: polC; PRK00448 632516004399 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 632516004400 generic binding surface II; other site 632516004401 generic binding surface I; other site 632516004402 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632516004403 active site 632516004404 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 632516004405 active site 632516004406 catalytic site [active] 632516004407 substrate binding site [chemical binding]; other site 632516004408 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 632516004409 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 632516004410 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 632516004411 Ligand binding site; other site 632516004412 Putative Catalytic site; other site 632516004413 DXD motif; other site 632516004414 GcpE protein; Region: GcpE; pfam04551 632516004415 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 632516004416 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 632516004417 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 632516004418 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 632516004419 active site 632516004420 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 632516004421 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 632516004422 putative substrate binding region [chemical binding]; other site 632516004423 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 632516004424 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 632516004425 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 632516004426 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 632516004427 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 632516004428 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 632516004429 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 632516004430 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 632516004431 catalytic residue [active] 632516004432 putative FPP diphosphate binding site; other site 632516004433 putative FPP binding hydrophobic cleft; other site 632516004434 dimer interface [polypeptide binding]; other site 632516004435 putative IPP diphosphate binding site; other site 632516004436 ribosome recycling factor; Reviewed; Region: frr; PRK00083 632516004437 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 632516004438 hinge region; other site 632516004439 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 632516004440 putative nucleotide binding site [chemical binding]; other site 632516004441 uridine monophosphate binding site [chemical binding]; other site 632516004442 homohexameric interface [polypeptide binding]; other site 632516004443 elongation factor Ts; Reviewed; Region: tsf; PRK12332 632516004444 UBA/TS-N domain; Region: UBA; pfam00627 632516004445 Elongation factor TS; Region: EF_TS; pfam00889 632516004446 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 632516004447 rRNA interaction site [nucleotide binding]; other site 632516004448 S8 interaction site; other site 632516004449 putative laminin-1 binding site; other site 632516004450 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632516004451 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 632516004452 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632516004453 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 632516004454 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 632516004455 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516004456 putative homodimer interface [polypeptide binding]; other site 632516004457 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 632516004458 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 632516004459 O-Antigen ligase; Region: Wzy_C; cl04850 632516004460 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 632516004461 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 632516004462 Domain of unknown function (DUF814); Region: DUF814; pfam05670 632516004463 6-phosphofructokinase; Provisional; Region: PRK14072 632516004464 active site 632516004465 ADP/pyrophosphate binding site [chemical binding]; other site 632516004466 dimerization interface [polypeptide binding]; other site 632516004467 allosteric effector site; other site 632516004468 fructose-1,6-bisphosphate binding site; other site 632516004469 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 632516004470 Clp amino terminal domain; Region: Clp_N; pfam02861 632516004471 Clp amino terminal domain; Region: Clp_N; pfam02861 632516004472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516004473 Walker A motif; other site 632516004474 ATP binding site [chemical binding]; other site 632516004475 Walker B motif; other site 632516004476 arginine finger; other site 632516004477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516004478 Walker A motif; other site 632516004479 ATP binding site [chemical binding]; other site 632516004480 Walker B motif; other site 632516004481 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 632516004482 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 632516004483 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 632516004484 ADP binding site [chemical binding]; other site 632516004485 phosphagen binding site; other site 632516004486 substrate specificity loop; other site 632516004487 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 632516004488 UvrB/uvrC motif; Region: UVR; pfam02151 632516004489 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 632516004490 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 632516004491 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 632516004492 NodB motif; other site 632516004493 active site 632516004494 catalytic site [active] 632516004495 Zn binding site [ion binding]; other site 632516004496 Probable zinc-binding domain; Region: zf-trcl; pfam13451 632516004497 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 632516004498 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 632516004499 elongation factor G; Reviewed; Region: PRK12740 632516004500 G1 box; other site 632516004501 putative GEF interaction site [polypeptide binding]; other site 632516004502 GTP/Mg2+ binding site [chemical binding]; other site 632516004503 Switch I region; other site 632516004504 G2 box; other site 632516004505 G3 box; other site 632516004506 Switch II region; other site 632516004507 G4 box; other site 632516004508 G5 box; other site 632516004509 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 632516004510 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 632516004511 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 632516004512 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 632516004513 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 632516004514 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516004515 Zn2+ binding site [ion binding]; other site 632516004516 Mg2+ binding site [ion binding]; other site 632516004517 UGMP family protein; Validated; Region: PRK09604 632516004518 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 632516004519 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 632516004520 Bacitracin resistance protein BacA; Region: BacA; pfam02673 632516004521 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 632516004522 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 632516004523 acetylornithine aminotransferase; Provisional; Region: PRK02627 632516004524 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632516004525 inhibitor-cofactor binding pocket; inhibition site 632516004526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516004527 catalytic residue [active] 632516004528 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 632516004529 Fe-S cluster binding site [ion binding]; other site 632516004530 active site 632516004531 S-layer homology domain; Region: SLH; pfam00395 632516004532 S-layer homology domain; Region: SLH; pfam00395 632516004533 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 632516004534 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 632516004535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632516004536 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 632516004537 Double zinc ribbon; Region: DZR; pfam12773 632516004538 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 632516004539 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 632516004540 cyclase homology domain; Region: CHD; cd07302 632516004541 nucleotidyl binding site; other site 632516004542 metal binding site [ion binding]; metal-binding site 632516004543 dimer interface [polypeptide binding]; other site 632516004544 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632516004545 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 632516004546 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632516004547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 632516004548 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632516004549 TPR motif; other site 632516004550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632516004551 binding surface 632516004552 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 632516004553 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 632516004554 Late competence development protein ComFB; Region: ComFB; pfam10719 632516004555 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 632516004556 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 632516004557 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 632516004558 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 632516004559 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 632516004560 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 632516004561 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 632516004562 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632516004563 Walker A motif; other site 632516004564 ATP binding site [chemical binding]; other site 632516004565 Walker B motif; other site 632516004566 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 632516004567 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 632516004568 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 632516004569 Walker A motif; other site 632516004570 ATP binding site [chemical binding]; other site 632516004571 Walker B motif; other site 632516004572 Response regulator receiver domain; Region: Response_reg; pfam00072 632516004573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516004574 active site 632516004575 phosphorylation site [posttranslational modification] 632516004576 intermolecular recognition site; other site 632516004577 dimerization interface [polypeptide binding]; other site 632516004578 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 632516004579 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 632516004580 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 632516004581 shikimate binding site; other site 632516004582 NAD(P) binding site [chemical binding]; other site 632516004583 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 632516004584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516004585 active site 632516004586 motif I; other site 632516004587 motif II; other site 632516004588 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 632516004589 Bacterial SH3 domain; Region: SH3_3; pfam08239 632516004590 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632516004591 NlpC/P60 family; Region: NLPC_P60; pfam00877 632516004592 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 632516004593 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632516004594 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632516004595 Walker A/P-loop; other site 632516004596 ATP binding site [chemical binding]; other site 632516004597 Q-loop/lid; other site 632516004598 ABC transporter signature motif; other site 632516004599 Walker B; other site 632516004600 D-loop; other site 632516004601 H-loop/switch region; other site 632516004602 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 632516004603 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632516004604 ABC-ATPase subunit interface; other site 632516004605 dimer interface [polypeptide binding]; other site 632516004606 putative PBP binding regions; other site 632516004607 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632516004608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632516004609 intersubunit interface [polypeptide binding]; other site 632516004610 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 632516004611 lipoyl-biotinyl attachment site [posttranslational modification]; other site 632516004612 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 632516004613 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 632516004614 catalytic residues [active] 632516004615 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 632516004616 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 632516004617 Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087 632516004618 Rho binding site 1 [polypeptide binding]; other site 632516004619 putative Rho binding site 2 [polypeptide binding]; other site 632516004620 PemK-like protein; Region: PemK; pfam02452 632516004621 alanine racemase; Reviewed; Region: alr; PRK00053 632516004622 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 632516004623 active site 632516004624 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632516004625 dimer interface [polypeptide binding]; other site 632516004626 substrate binding site [chemical binding]; other site 632516004627 catalytic residues [active] 632516004628 Uncharacterized conserved protein [Function unknown]; Region: COG0062 632516004629 putative carbohydrate kinase; Provisional; Region: PRK10565 632516004630 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 632516004631 putative substrate binding site [chemical binding]; other site 632516004632 putative ATP binding site [chemical binding]; other site 632516004633 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 632516004634 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 632516004635 conserved cys residue [active] 632516004636 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 632516004637 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 632516004638 active site 632516004639 multimer interface [polypeptide binding]; other site 632516004640 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 632516004641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632516004642 DNA-binding site [nucleotide binding]; DNA binding site 632516004643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632516004644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516004645 homodimer interface [polypeptide binding]; other site 632516004646 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632516004647 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 632516004648 metal binding site [ion binding]; metal-binding site 632516004649 dimer interface [polypeptide binding]; other site 632516004650 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 632516004651 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 632516004652 peptide binding site [polypeptide binding]; other site 632516004653 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632516004654 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 632516004655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632516004656 Walker A/P-loop; other site 632516004657 ATP binding site [chemical binding]; other site 632516004658 Q-loop/lid; other site 632516004659 ABC transporter signature motif; other site 632516004660 Walker B; other site 632516004661 D-loop; other site 632516004662 H-loop/switch region; other site 632516004663 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 632516004664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 632516004665 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 632516004666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516004667 dimer interface [polypeptide binding]; other site 632516004668 conserved gate region; other site 632516004669 putative PBP binding loops; other site 632516004670 ABC-ATPase subunit interface; other site 632516004671 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516004672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516004673 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516004674 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632516004675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516004676 dimer interface [polypeptide binding]; other site 632516004677 conserved gate region; other site 632516004678 putative PBP binding loops; other site 632516004679 ABC-ATPase subunit interface; other site 632516004680 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 632516004681 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 632516004682 NAD binding site [chemical binding]; other site 632516004683 dimer interface [polypeptide binding]; other site 632516004684 substrate binding site [chemical binding]; other site 632516004685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632516004686 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 632516004687 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 632516004688 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 632516004689 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 632516004690 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 632516004691 Competence protein; Region: Competence; pfam03772 632516004692 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 632516004693 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632516004694 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 632516004695 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 632516004696 active site 632516004697 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 632516004698 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 632516004699 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 632516004700 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 632516004701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516004702 FeS/SAM binding site; other site 632516004703 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 632516004704 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 632516004705 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 632516004706 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 632516004707 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 632516004708 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 632516004709 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 632516004710 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 632516004711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516004712 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632516004713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632516004714 DNA binding residues [nucleotide binding] 632516004715 DNA primase; Validated; Region: dnaG; PRK05667 632516004716 CHC2 zinc finger; Region: zf-CHC2; pfam01807 632516004717 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 632516004718 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 632516004719 active site 632516004720 metal binding site [ion binding]; metal-binding site 632516004721 interdomain interaction site; other site 632516004722 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 632516004723 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 632516004724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516004725 Zn2+ binding site [ion binding]; other site 632516004726 Mg2+ binding site [ion binding]; other site 632516004727 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 632516004728 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 632516004729 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 632516004730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516004731 Walker A motif; other site 632516004732 ATP binding site [chemical binding]; other site 632516004733 Walker B motif; other site 632516004734 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 632516004735 Clp protease; Region: CLP_protease; pfam00574 632516004736 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 632516004737 oligomer interface [polypeptide binding]; other site 632516004738 active site residues [active] 632516004739 trigger factor; Provisional; Region: tig; PRK01490 632516004740 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 632516004741 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 632516004742 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632516004743 putative active site [active] 632516004744 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 632516004745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 632516004746 Beta-Casp domain; Region: Beta-Casp; smart01027 632516004747 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632516004748 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 632516004749 EamA-like transporter family; Region: EamA; pfam00892 632516004750 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632516004751 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 632516004752 Walker A/P-loop; other site 632516004753 ATP binding site [chemical binding]; other site 632516004754 Q-loop/lid; other site 632516004755 ABC transporter signature motif; other site 632516004756 Walker B; other site 632516004757 D-loop; other site 632516004758 H-loop/switch region; other site 632516004759 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 632516004760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516004761 dimer interface [polypeptide binding]; other site 632516004762 conserved gate region; other site 632516004763 putative PBP binding loops; other site 632516004764 ABC-ATPase subunit interface; other site 632516004765 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632516004766 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632516004767 substrate binding pocket [chemical binding]; other site 632516004768 membrane-bound complex binding site; other site 632516004769 hinge residues; other site 632516004770 S-layer homology domain; Region: SLH; pfam00395 632516004771 S-layer homology domain; Region: SLH; pfam00395 632516004772 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632516004773 Interdomain contacts; other site 632516004774 Cytokine receptor motif; other site 632516004775 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 632516004776 Interdomain contacts; other site 632516004777 Cytokine receptor motif; other site 632516004778 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 632516004779 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 632516004780 active site 632516004781 homodimer interface [polypeptide binding]; other site 632516004782 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 632516004783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516004784 FeS/SAM binding site; other site 632516004785 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 632516004786 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 632516004787 putative active site [active] 632516004788 dimerization interface [polypeptide binding]; other site 632516004789 putative tRNAtyr binding site [nucleotide binding]; other site 632516004790 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 632516004791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516004792 Zn2+ binding site [ion binding]; other site 632516004793 Mg2+ binding site [ion binding]; other site 632516004794 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 632516004795 synthetase active site [active] 632516004796 NTP binding site [chemical binding]; other site 632516004797 metal binding site [ion binding]; metal-binding site 632516004798 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 632516004799 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 632516004800 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516004801 active site 632516004802 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 632516004803 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 632516004804 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 632516004805 Spore germination protein; Region: Spore_permease; cl17796 632516004806 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 632516004807 hypothetical protein; Provisional; Region: PRK04435 632516004808 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 632516004809 homoserine dehydrogenase; Provisional; Region: PRK06349 632516004810 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 632516004811 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 632516004812 homoserine kinase; Provisional; Region: PRK01212 632516004813 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632516004814 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632516004815 aspartate kinase; Reviewed; Region: PRK06635 632516004816 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 632516004817 putative catalytic residues [active] 632516004818 putative nucleotide binding site [chemical binding]; other site 632516004819 putative aspartate binding site [chemical binding]; other site 632516004820 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 632516004821 putative allosteric regulatory site; other site 632516004822 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 632516004823 putative allosteric regulatory residue; other site 632516004824 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632516004825 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516004826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516004827 Walker A/P-loop; other site 632516004828 ATP binding site [chemical binding]; other site 632516004829 Q-loop/lid; other site 632516004830 ABC transporter signature motif; other site 632516004831 Walker B; other site 632516004832 D-loop; other site 632516004833 H-loop/switch region; other site 632516004834 Protein of unknown function (DUF2679); Region: DUF2679; pfam10882 632516004835 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632516004836 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632516004837 DNA interaction; other site 632516004838 Metal-binding active site; metal-binding site 632516004839 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 632516004840 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 632516004841 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 632516004842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632516004843 Coenzyme A binding pocket [chemical binding]; other site 632516004844 Coat F domain; Region: Coat_F; pfam07875 632516004845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 632516004846 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 632516004847 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 632516004848 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 632516004849 tetramerization interface [polypeptide binding]; other site 632516004850 active site 632516004851 pantoate--beta-alanine ligase; Region: panC; TIGR00018 632516004852 Pantoate-beta-alanine ligase; Region: PanC; cd00560 632516004853 active site 632516004854 ATP-binding site [chemical binding]; other site 632516004855 pantoate-binding site; other site 632516004856 HXXH motif; other site 632516004857 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 632516004858 oligomerization interface [polypeptide binding]; other site 632516004859 active site 632516004860 metal binding site [ion binding]; metal-binding site 632516004861 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 632516004862 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 632516004863 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 632516004864 Ferritin-like domain; Region: Ferritin; pfam00210 632516004865 ferroxidase diiron center [ion binding]; other site 632516004866 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 632516004867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632516004868 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632516004869 DNA-binding interface [nucleotide binding]; DNA binding site 632516004870 Integrase core domain; Region: rve; pfam00665 632516004871 Helix-turn-helix domain; Region: HTH_17; pfam12728 632516004872 Helix-turn-helix domain; Region: HTH_17; pfam12728 632516004873 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 632516004874 putative active site [active] 632516004875 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 632516004876 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 632516004877 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 632516004878 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 632516004879 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 632516004880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 632516004881 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 632516004882 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 632516004883 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 632516004884 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 632516004885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632516004886 Zn2+ binding site [ion binding]; other site 632516004887 Mg2+ binding site [ion binding]; other site 632516004888 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 632516004889 HTH domain; Region: HTH_11; cl17392 632516004890 WYL domain; Region: WYL; pfam13280 632516004891 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632516004892 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516004893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516004894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516004895 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516004896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516004897 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516004898 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516004899 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 632516004900 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 632516004901 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516004902 Transposase domain (DUF772); Region: DUF772; pfam05598 632516004903 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632516004904 Protein of unknown function (DUF433); Region: DUF433; pfam04255 632516004905 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 632516004906 PemK-like protein; Region: PemK; pfam02452 632516004907 BRO family, N-terminal domain; Region: Bro-N; smart01040 632516004908 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 632516004909 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 632516004910 toxin interface [polypeptide binding]; other site 632516004911 Zn binding site [ion binding]; other site 632516004912 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 632516004913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 632516004914 Homeodomain-like domain; Region: HTH_23; pfam13384 632516004915 Integrase core domain; Region: rve; pfam00665 632516004916 Integrase core domain; Region: rve_3; cl15866 632516004917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516004918 Walker A motif; other site 632516004919 ATP binding site [chemical binding]; other site 632516004920 Walker B motif; other site 632516004921 arginine finger; other site 632516004922 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632516004923 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 632516004924 Int/Topo IB signature motif; other site 632516004925 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632516004926 putative active site [active] 632516004927 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632516004928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632516004929 non-specific DNA binding site [nucleotide binding]; other site 632516004930 salt bridge; other site 632516004931 sequence-specific DNA binding site [nucleotide binding]; other site 632516004932 Helix-turn-helix domain; Region: HTH_17; pfam12728 632516004933 potential frameshift: common BLAST hit: gi|158320328|ref|YP_001512835.1| zinc finger CHC2-family protein 632516004934 CHC2 zinc finger; Region: zf-CHC2; cl17510 632516004935 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 632516004936 active site 632516004937 metal binding site [ion binding]; metal-binding site 632516004938 interdomain interaction site; other site 632516004939 Domain of unknown function (DUF927); Region: DUF927; cl12098 632516004940 Transposase domain (DUF772); Region: DUF772; pfam05598 632516004941 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632516004942 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 632516004943 Putative amidase domain; Region: Amidase_6; pfam12671 632516004944 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516004945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516004946 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516004947 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516004948 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632516004949 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 632516004950 Walker A/P-loop; other site 632516004951 ATP binding site [chemical binding]; other site 632516004952 Q-loop/lid; other site 632516004953 ABC transporter signature motif; other site 632516004954 Walker B; other site 632516004955 D-loop; other site 632516004956 H-loop/switch region; other site 632516004957 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632516004958 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 632516004959 Walker A/P-loop; other site 632516004960 ATP binding site [chemical binding]; other site 632516004961 Q-loop/lid; other site 632516004962 ABC transporter signature motif; other site 632516004963 Walker B; other site 632516004964 D-loop; other site 632516004965 H-loop/switch region; other site 632516004966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516004967 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516004968 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516004969 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 632516004970 active site 632516004971 nucleotide-binding site [chemical binding]; other site 632516004972 Transposase domain (DUF772); Region: DUF772; pfam05598 632516004973 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632516004974 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 632516004975 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 632516004976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516004977 FeS/SAM binding site; other site 632516004978 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 632516004979 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 632516004980 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 632516004981 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 632516004982 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 632516004983 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 632516004984 active site 632516004985 HIGH motif; other site 632516004986 dimer interface [polypeptide binding]; other site 632516004987 KMSKS motif; other site 632516004988 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632516004989 RNA binding surface [nucleotide binding]; other site 632516004990 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 632516004991 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 632516004992 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 632516004993 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 632516004994 active site 632516004995 putative substrate binding pocket [chemical binding]; other site 632516004996 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 632516004997 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 632516004998 homotetramer interface [polypeptide binding]; other site 632516004999 ligand binding site [chemical binding]; other site 632516005000 catalytic site [active] 632516005001 NAD binding site [chemical binding]; other site 632516005002 replicative DNA helicase; Region: DnaB; TIGR00665 632516005003 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 632516005004 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 632516005005 Walker A motif; other site 632516005006 ATP binding site [chemical binding]; other site 632516005007 Walker B motif; other site 632516005008 DNA binding loops [nucleotide binding] 632516005009 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 632516005010 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 632516005011 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 632516005012 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 632516005013 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 632516005014 DHH family; Region: DHH; pfam01368 632516005015 DHHA1 domain; Region: DHHA1; pfam02272 632516005016 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 632516005017 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 632516005018 Prephenate dehydratase; Region: PDT; pfam00800 632516005019 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 632516005020 putative L-Phe binding site [chemical binding]; other site 632516005021 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 632516005022 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 632516005023 TPP-binding site [chemical binding]; other site 632516005024 putative dimer interface [polypeptide binding]; other site 632516005025 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 632516005026 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632516005027 dimer interface [polypeptide binding]; other site 632516005028 PYR/PP interface [polypeptide binding]; other site 632516005029 TPP binding site [chemical binding]; other site 632516005030 substrate binding site [chemical binding]; other site 632516005031 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 632516005032 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 632516005033 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 632516005034 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 632516005035 Uncharacterized conserved protein [Function unknown]; Region: COG0398 632516005036 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 632516005037 seryl-tRNA synthetase; Provisional; Region: PRK05431 632516005038 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 632516005039 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 632516005040 dimer interface [polypeptide binding]; other site 632516005041 active site 632516005042 motif 1; other site 632516005043 motif 2; other site 632516005044 motif 3; other site 632516005045 Protein of unknown function DUF45; Region: DUF45; pfam01863 632516005046 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 632516005047 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 632516005048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516005049 ATP binding site [chemical binding]; other site 632516005050 putative Mg++ binding site [ion binding]; other site 632516005051 Protein of unknown function DUF86; Region: DUF86; cl01031 632516005052 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632516005053 active site 632516005054 NTP binding site [chemical binding]; other site 632516005055 metal binding triad [ion binding]; metal-binding site 632516005056 antibiotic binding site [chemical binding]; other site 632516005057 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 632516005058 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 632516005059 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 632516005060 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632516005061 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516005062 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 632516005063 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632516005064 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632516005065 Walker A/P-loop; other site 632516005066 ATP binding site [chemical binding]; other site 632516005067 Q-loop/lid; other site 632516005068 ABC transporter signature motif; other site 632516005069 Walker B; other site 632516005070 D-loop; other site 632516005071 H-loop/switch region; other site 632516005072 Cobalt transport protein; Region: CbiQ; cl00463 632516005073 PDGLE domain; Region: PDGLE; pfam13190 632516005074 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 632516005075 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 632516005076 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 632516005077 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 632516005078 MgtE intracellular N domain; Region: MgtE_N; pfam03448 632516005079 FOG: CBS domain [General function prediction only]; Region: COG0517 632516005080 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 632516005081 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 632516005082 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 632516005083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516005084 catalytic residue [active] 632516005085 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 632516005086 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 632516005087 CoA binding domain; Region: CoA_binding; smart00881 632516005088 hypothetical protein; Provisional; Region: PRK08582 632516005089 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 632516005090 RNA binding site [nucleotide binding]; other site 632516005091 Septum formation initiator; Region: DivIC; cl17659 632516005092 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 632516005093 YabP family; Region: YabP; cl06766 632516005094 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632516005095 RNA binding surface [nucleotide binding]; other site 632516005096 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 632516005097 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 632516005098 IHF dimer interface [polypeptide binding]; other site 632516005099 IHF - DNA interface [nucleotide binding]; other site 632516005100 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 632516005101 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 632516005102 homodimer interface [polypeptide binding]; other site 632516005103 metal binding site [ion binding]; metal-binding site 632516005104 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 632516005105 homodimer interface [polypeptide binding]; other site 632516005106 active site 632516005107 putative chemical substrate binding site [chemical binding]; other site 632516005108 metal binding site [ion binding]; metal-binding site 632516005109 Stage III sporulation protein D; Region: SpoIIID; pfam12116 632516005110 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 632516005111 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 632516005112 FAD binding pocket [chemical binding]; other site 632516005113 FAD binding motif [chemical binding]; other site 632516005114 phosphate binding motif [ion binding]; other site 632516005115 beta-alpha-beta structure motif; other site 632516005116 NAD binding pocket [chemical binding]; other site 632516005117 Iron coordination center [ion binding]; other site 632516005118 putative oxidoreductase; Provisional; Region: PRK12831 632516005119 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632516005120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632516005121 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 632516005122 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 632516005123 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 632516005124 FtsH Extracellular; Region: FtsH_ext; pfam06480 632516005125 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 632516005126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516005127 Walker A motif; other site 632516005128 ATP binding site [chemical binding]; other site 632516005129 Walker B motif; other site 632516005130 arginine finger; other site 632516005131 Peptidase family M41; Region: Peptidase_M41; pfam01434 632516005132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516005133 active site 632516005134 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 632516005135 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 632516005136 Ligand Binding Site [chemical binding]; other site 632516005137 TilS substrate C-terminal domain; Region: TilS_C; smart00977 632516005138 SurA N-terminal domain; Region: SurA_N_3; cl07813 632516005139 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 632516005140 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 632516005141 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 632516005142 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516005143 ATP binding site [chemical binding]; other site 632516005144 putative Mg++ binding site [ion binding]; other site 632516005145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632516005146 nucleotide binding region [chemical binding]; other site 632516005147 ATP-binding site [chemical binding]; other site 632516005148 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 632516005149 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 632516005150 putative active site [active] 632516005151 catalytic residue [active] 632516005152 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 632516005153 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 632516005154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516005155 active site 632516005156 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 632516005157 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 632516005158 Substrate binding site; other site 632516005159 Mg++ binding site; other site 632516005160 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 632516005161 active site 632516005162 substrate binding site [chemical binding]; other site 632516005163 CoA binding site [chemical binding]; other site 632516005164 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 632516005165 catalytic motif [active] 632516005166 Zn binding site [ion binding]; other site 632516005167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632516005168 active site 632516005169 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 632516005170 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 632516005171 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632516005172 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632516005173 hinge; other site 632516005174 active site 632516005175 Predicted amidohydrolase [General function prediction only]; Region: COG0388 632516005176 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 632516005177 active site 632516005178 catalytic triad [active] 632516005179 dimer interface [polypeptide binding]; other site 632516005180 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 632516005181 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 632516005182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632516005183 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632516005184 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 632516005185 Protein export membrane protein; Region: SecD_SecF; pfam02355 632516005186 protein-export membrane protein SecD; Region: secD; TIGR01129 632516005187 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 632516005188 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 632516005189 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 632516005190 trimer interface [polypeptide binding]; other site 632516005191 putative metal binding site [ion binding]; other site 632516005192 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 632516005193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516005194 FeS/SAM binding site; other site 632516005195 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 632516005196 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 632516005197 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516005198 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 632516005199 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 632516005200 intersubunit interface [polypeptide binding]; other site 632516005201 active site 632516005202 zinc binding site [ion binding]; other site 632516005203 Na+ binding site [ion binding]; other site 632516005204 putative hydrolase; Validated; Region: PRK09248 632516005205 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 632516005206 active site 632516005207 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 632516005208 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 632516005209 dimer interface [polypeptide binding]; other site 632516005210 active site 632516005211 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 632516005212 dimer interface [polypeptide binding]; other site 632516005213 active site 632516005214 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632516005215 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 632516005216 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 632516005217 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 632516005218 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632516005219 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632516005220 nucleotide binding site [chemical binding]; other site 632516005221 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516005222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516005223 dimer interface [polypeptide binding]; other site 632516005224 conserved gate region; other site 632516005225 putative PBP binding loops; other site 632516005226 ABC-ATPase subunit interface; other site 632516005227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516005228 dimer interface [polypeptide binding]; other site 632516005229 conserved gate region; other site 632516005230 putative PBP binding loops; other site 632516005231 ABC-ATPase subunit interface; other site 632516005232 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516005233 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516005234 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 632516005235 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632516005236 minor groove reading motif; other site 632516005237 helix-hairpin-helix signature motif; other site 632516005238 substrate binding pocket [chemical binding]; other site 632516005239 active site 632516005240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 632516005241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 632516005242 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632516005243 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 632516005244 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 632516005245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632516005246 ATP binding site [chemical binding]; other site 632516005247 Mg2+ binding site [ion binding]; other site 632516005248 G-X-G motif; other site 632516005249 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 632516005250 nucleoside/Zn binding site; other site 632516005251 dimer interface [polypeptide binding]; other site 632516005252 catalytic motif [active] 632516005253 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516005254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516005255 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516005256 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 632516005257 ATP cone domain; Region: ATP-cone; pfam03477 632516005258 Class III ribonucleotide reductase; Region: RNR_III; cd01675 632516005259 effector binding site; other site 632516005260 active site 632516005261 Zn binding site [ion binding]; other site 632516005262 glycine loop; other site 632516005263 4Fe-4S binding domain; Region: Fer4_5; pfam12801 632516005264 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632516005265 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 632516005266 aspartate aminotransferase; Provisional; Region: PRK06290 632516005267 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632516005268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516005269 homodimer interface [polypeptide binding]; other site 632516005270 catalytic residue [active] 632516005271 hypothetical protein; Provisional; Region: PRK02877 632516005272 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632516005273 nucleotide binding site [chemical binding]; other site 632516005274 Type III pantothenate kinase; Region: Pan_kinase; cl17198 632516005275 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 632516005276 Ecdysteroid kinase; Region: EcKinase; cl17738 632516005277 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 632516005278 substrate binding site [chemical binding]; other site 632516005279 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 632516005280 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 632516005281 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 632516005282 substrate binding site [chemical binding]; other site 632516005283 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 632516005284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516005285 ATP binding site [chemical binding]; other site 632516005286 Mg2+ binding site [ion binding]; other site 632516005287 G-X-G motif; other site 632516005288 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632516005289 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 632516005290 putative NAD(P) binding site [chemical binding]; other site 632516005291 catalytic Zn binding site [ion binding]; other site 632516005292 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516005293 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 632516005294 active site 632516005295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516005296 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516005297 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516005298 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516005299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516005300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516005301 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516005302 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632516005303 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632516005304 G5 domain; Region: G5; pfam07501 632516005305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 632516005306 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 632516005307 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 632516005308 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 632516005309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632516005310 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632516005311 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632516005312 active site residue [active] 632516005313 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 632516005314 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 632516005315 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 632516005316 active site 632516005317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632516005318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632516005319 metal binding site [ion binding]; metal-binding site 632516005320 active site 632516005321 I-site; other site 632516005322 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 632516005323 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 632516005324 NAD binding site [chemical binding]; other site 632516005325 sugar binding site [chemical binding]; other site 632516005326 divalent metal binding site [ion binding]; other site 632516005327 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 632516005328 dimer interface [polypeptide binding]; other site 632516005329 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 632516005330 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632516005331 active site 632516005332 FMN binding site [chemical binding]; other site 632516005333 substrate binding site [chemical binding]; other site 632516005334 3Fe-4S cluster binding site [ion binding]; other site 632516005335 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632516005336 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 632516005337 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 632516005338 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 632516005339 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 632516005340 active site 632516005341 HIGH motif; other site 632516005342 KMSK motif region; other site 632516005343 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 632516005344 tRNA binding surface [nucleotide binding]; other site 632516005345 anticodon binding site; other site 632516005346 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 632516005347 glutamate racemase; Provisional; Region: PRK00865 632516005348 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 632516005349 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 632516005350 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 632516005351 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 632516005352 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 632516005353 active site 632516005354 substrate binding site [chemical binding]; other site 632516005355 metal binding site [ion binding]; metal-binding site 632516005356 RNA polymerase factor sigma-70; Validated; Region: PRK08295 632516005357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516005358 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632516005359 YacP-like NYN domain; Region: NYN_YacP; pfam05991 632516005360 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632516005361 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 632516005362 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 632516005363 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 632516005364 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 632516005365 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 632516005366 DNA replication protein DnaC; Validated; Region: PRK06835 632516005367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516005368 Walker A motif; other site 632516005369 ATP binding site [chemical binding]; other site 632516005370 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 632516005371 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 632516005372 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 632516005373 dimerization interface [polypeptide binding]; other site 632516005374 active site 632516005375 metal binding site [ion binding]; metal-binding site 632516005376 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 632516005377 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 632516005378 homodimer interface [polypeptide binding]; other site 632516005379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516005380 catalytic residue [active] 632516005381 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 632516005382 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 632516005383 MgtC family; Region: MgtC; pfam02308 632516005384 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516005385 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516005386 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516005387 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516005388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516005389 dimer interface [polypeptide binding]; other site 632516005390 conserved gate region; other site 632516005391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632516005392 ABC-ATPase subunit interface; other site 632516005393 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632516005394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516005395 dimer interface [polypeptide binding]; other site 632516005396 conserved gate region; other site 632516005397 ABC-ATPase subunit interface; other site 632516005398 Response regulator receiver domain; Region: Response_reg; pfam00072 632516005399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516005400 active site 632516005401 phosphorylation site [posttranslational modification] 632516005402 intermolecular recognition site; other site 632516005403 dimerization interface [polypeptide binding]; other site 632516005404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516005405 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632516005406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516005407 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 632516005408 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632516005409 dimerization interface [polypeptide binding]; other site 632516005410 Histidine kinase; Region: His_kinase; pfam06580 632516005411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516005412 ATP binding site [chemical binding]; other site 632516005413 Mg2+ binding site [ion binding]; other site 632516005414 G-X-G motif; other site 632516005415 putative alpha-glucosidase; Provisional; Region: PRK10658 632516005416 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 632516005417 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 632516005418 active site 632516005419 homotrimer interface [polypeptide binding]; other site 632516005420 catalytic site [active] 632516005421 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 632516005422 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 632516005423 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632516005424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516005425 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 632516005426 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 632516005427 PYR/PP interface [polypeptide binding]; other site 632516005428 dimer interface [polypeptide binding]; other site 632516005429 TPP binding site [chemical binding]; other site 632516005430 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632516005431 transketolase; Reviewed; Region: PRK05899 632516005432 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 632516005433 TPP-binding site [chemical binding]; other site 632516005434 dimer interface [polypeptide binding]; other site 632516005435 Uncharacterized conserved protein [Function unknown]; Region: COG1284 632516005436 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 632516005437 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 632516005438 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 632516005439 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 632516005440 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 632516005441 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 632516005442 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 632516005443 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 632516005444 DNA repair protein RadA; Provisional; Region: PRK11823 632516005445 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 632516005446 Walker A motif/ATP binding site; other site 632516005447 ATP binding site [chemical binding]; other site 632516005448 Walker B motif; other site 632516005449 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 632516005450 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516005451 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632516005452 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 632516005453 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632516005454 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 632516005455 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 632516005456 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 632516005457 23S rRNA interface [nucleotide binding]; other site 632516005458 L3 interface [polypeptide binding]; other site 632516005459 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516005460 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 632516005461 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 632516005462 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 632516005463 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632516005464 dimer interface [polypeptide binding]; other site 632516005465 ssDNA binding site [nucleotide binding]; other site 632516005466 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632516005467 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 632516005468 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 632516005469 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632516005470 active site 632516005471 catalytic tetrad [active] 632516005472 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632516005473 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 632516005474 tartrate dehydrogenase; Region: TTC; TIGR02089 632516005475 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 632516005476 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 632516005477 substrate binding site [chemical binding]; other site 632516005478 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 632516005479 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 632516005480 substrate binding site [chemical binding]; other site 632516005481 ligand binding site [chemical binding]; other site 632516005482 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 632516005483 peptide chain release factor 2; Validated; Region: prfB; PRK00578 632516005484 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 632516005485 linker region; other site 632516005486 This domain is found in peptide chain release factors; Region: PCRF; smart00937 632516005487 RF-1 domain; Region: RF-1; pfam00472 632516005488 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 632516005489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516005490 ATP binding site [chemical binding]; other site 632516005491 putative Mg++ binding site [ion binding]; other site 632516005492 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 632516005493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632516005494 nucleotide binding region [chemical binding]; other site 632516005495 ATP-binding site [chemical binding]; other site 632516005496 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 632516005497 30S subunit binding site; other site 632516005498 Uncharacterized conserved protein [Function unknown]; Region: COG2006 632516005499 Domain of unknown function (DUF362); Region: DUF362; pfam04015 632516005500 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 632516005501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516005502 Walker A motif; other site 632516005503 ATP binding site [chemical binding]; other site 632516005504 Walker B motif; other site 632516005505 arginine finger; other site 632516005506 ribonuclease R; Region: RNase_R; TIGR02063 632516005507 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 632516005508 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 632516005509 RNB domain; Region: RNB; pfam00773 632516005510 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 632516005511 RNA binding site [nucleotide binding]; other site 632516005512 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 632516005513 Zn2+ binding site [ion binding]; other site 632516005514 Mg2+ binding site [ion binding]; other site 632516005515 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 632516005516 active site 632516005517 catalytic residues [active] 632516005518 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516005519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516005520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516005521 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516005522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516005523 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516005524 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516005525 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 632516005526 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 632516005527 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 632516005528 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 632516005529 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 632516005530 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632516005531 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 632516005532 putative substrate binding site [chemical binding]; other site 632516005533 putative ATP binding site [chemical binding]; other site 632516005534 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 632516005535 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 632516005536 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 632516005537 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632516005538 metal ion-dependent adhesion site (MIDAS); other site 632516005539 Right handed beta helix region; Region: Beta_helix; pfam13229 632516005540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 632516005541 Homeodomain-like domain; Region: HTH_23; pfam13384 632516005542 Integrase core domain; Region: rve; pfam00665 632516005543 Integrase core domain; Region: rve_3; cl15866 632516005544 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 632516005545 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 632516005546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516005547 motif II; other site 632516005548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516005549 Uncharacterized conserved protein [Function unknown]; Region: COG4198 632516005550 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 632516005551 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 632516005552 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 632516005553 ligand binding site [chemical binding]; other site 632516005554 NAD binding site [chemical binding]; other site 632516005555 dimerization interface [polypeptide binding]; other site 632516005556 catalytic site [active] 632516005557 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 632516005558 putative L-serine binding site [chemical binding]; other site 632516005559 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 632516005560 homodimer interface [polypeptide binding]; other site 632516005561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516005562 catalytic residue [active] 632516005563 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632516005564 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516005565 elongation factor P; Validated; Region: PRK00529 632516005566 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 632516005567 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 632516005568 RNA binding site [nucleotide binding]; other site 632516005569 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 632516005570 RNA binding site [nucleotide binding]; other site 632516005571 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 632516005572 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 632516005573 homodimer interface [polypeptide binding]; other site 632516005574 oligonucleotide binding site [chemical binding]; other site 632516005575 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 632516005576 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 632516005577 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 632516005578 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 632516005579 B12 binding site [chemical binding]; other site 632516005580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516005581 FeS/SAM binding site; other site 632516005582 EDD domain protein, DegV family; Region: DegV; TIGR00762 632516005583 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 632516005584 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 632516005585 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 632516005586 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 632516005587 Uncharacterized conserved protein [Function unknown]; Region: COG2006 632516005588 Domain of unknown function (DUF362); Region: DUF362; pfam04015 632516005589 4Fe-4S binding domain; Region: Fer4_6; pfam12837 632516005590 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632516005591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516005592 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 632516005593 active site 632516005594 motif I; other site 632516005595 motif II; other site 632516005596 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516005597 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 632516005598 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 632516005599 ring oligomerisation interface [polypeptide binding]; other site 632516005600 ATP/Mg binding site [chemical binding]; other site 632516005601 stacking interactions; other site 632516005602 hinge regions; other site 632516005603 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 632516005604 oligomerisation interface [polypeptide binding]; other site 632516005605 mobile loop; other site 632516005606 roof hairpin; other site 632516005607 Cupin domain; Region: Cupin_2; pfam07883 632516005608 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 632516005609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516005610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516005611 Protein of unknown function (DUF342); Region: DUF342; pfam03961 632516005612 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 632516005613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632516005614 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632516005615 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632516005616 DNA binding residues [nucleotide binding] 632516005617 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 632516005618 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 632516005619 CheC-like family; Region: CheC; pfam04509 632516005620 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 632516005621 CheC-like family; Region: CheC; pfam04509 632516005622 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 632516005623 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 632516005624 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 632516005625 putative binding surface; other site 632516005626 active site 632516005627 P2 response regulator binding domain; Region: P2; pfam07194 632516005628 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 632516005629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516005630 ATP binding site [chemical binding]; other site 632516005631 Mg2+ binding site [ion binding]; other site 632516005632 G-X-G motif; other site 632516005633 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 632516005634 Flagellar protein YcgR; Region: YcgR_2; pfam12945 632516005635 PilZ domain; Region: PilZ; pfam07238 632516005636 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 632516005637 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 632516005638 P-loop; other site 632516005639 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 632516005640 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632516005641 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 632516005642 FHIPEP family; Region: FHIPEP; pfam00771 632516005643 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 632516005644 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 632516005645 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 632516005646 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 632516005647 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 632516005648 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 632516005649 Response regulator receiver domain; Region: Response_reg; pfam00072 632516005650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516005651 active site 632516005652 phosphorylation site [posttranslational modification] 632516005653 intermolecular recognition site; other site 632516005654 dimerization interface [polypeptide binding]; other site 632516005655 flagellar motor switch protein; Validated; Region: PRK08119 632516005656 CheC-like family; Region: CheC; pfam04509 632516005657 CheC-like family; Region: CheC; pfam04509 632516005658 flagellar motor switch protein FliN; Region: fliN; TIGR02480 632516005659 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 632516005660 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 632516005661 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 632516005662 Flagellar protein (FlbD); Region: FlbD; pfam06289 632516005663 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 632516005664 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 632516005665 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 632516005666 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 632516005667 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 632516005668 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 632516005669 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 632516005670 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 632516005671 Uncharacterized conserved protein [Function unknown]; Region: COG3334 632516005672 MgtE intracellular N domain; Region: MgtE_N; cl15244 632516005673 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 632516005674 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 632516005675 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 632516005676 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 632516005677 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 632516005678 Walker A motif/ATP binding site; other site 632516005679 Walker B motif; other site 632516005680 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 632516005681 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 632516005682 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 632516005683 FliG C-terminal domain; Region: FliG_C; pfam01706 632516005684 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 632516005685 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 632516005686 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 632516005687 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 632516005688 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 632516005689 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 632516005690 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 632516005691 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 632516005692 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 632516005693 transcriptional repressor CodY; Validated; Region: PRK04158 632516005694 CodY GAF-like domain; Region: CodY; pfam06018 632516005695 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 632516005696 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 632516005697 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 632516005698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516005699 Walker A motif; other site 632516005700 ATP binding site [chemical binding]; other site 632516005701 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 632516005702 Walker B motif; other site 632516005703 arginine finger; other site 632516005704 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 632516005705 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 632516005706 active site 632516005707 HslU subunit interaction site [polypeptide binding]; other site 632516005708 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 632516005709 Glucose inhibited division protein A; Region: GIDA; pfam01134 632516005710 DNA topoisomerase I; Validated; Region: PRK05582 632516005711 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 632516005712 active site 632516005713 interdomain interaction site; other site 632516005714 putative metal-binding site [ion binding]; other site 632516005715 nucleotide binding site [chemical binding]; other site 632516005716 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 632516005717 domain I; other site 632516005718 DNA binding groove [nucleotide binding] 632516005719 phosphate binding site [ion binding]; other site 632516005720 domain II; other site 632516005721 domain III; other site 632516005722 nucleotide binding site [chemical binding]; other site 632516005723 catalytic site [active] 632516005724 domain IV; other site 632516005725 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 632516005726 RNA polymerase subunit 9; Region: RPOL9; smart00661 632516005727 DNA protecting protein DprA; Region: dprA; TIGR00732 632516005728 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 632516005729 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 632516005730 hypothetical protein; Reviewed; Region: PRK09588 632516005731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516005732 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632516005733 FeS/SAM binding site; other site 632516005734 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 632516005735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632516005736 dimerization interface [polypeptide binding]; other site 632516005737 putative DNA binding site [nucleotide binding]; other site 632516005738 putative Zn2+ binding site [ion binding]; other site 632516005739 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632516005740 metal binding site 2 [ion binding]; metal-binding site 632516005741 putative DNA binding helix; other site 632516005742 metal binding site 1 [ion binding]; metal-binding site 632516005743 dimer interface [polypeptide binding]; other site 632516005744 structural Zn2+ binding site [ion binding]; other site 632516005745 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632516005746 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 632516005747 intersubunit interface [polypeptide binding]; other site 632516005748 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 632516005749 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 632516005750 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 632516005751 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632516005752 ABC-ATPase subunit interface; other site 632516005753 dimer interface [polypeptide binding]; other site 632516005754 putative PBP binding regions; other site 632516005755 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 632516005756 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 632516005757 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516005758 Walker A motif; other site 632516005759 ATP binding site [chemical binding]; other site 632516005760 Walker B motif; other site 632516005761 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 632516005762 Uncharacterized conserved protein [Function unknown]; Region: COG2445 632516005763 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632516005764 active site 632516005765 NTP binding site [chemical binding]; other site 632516005766 metal binding triad [ion binding]; metal-binding site 632516005767 antibiotic binding site [chemical binding]; other site 632516005768 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 632516005769 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 632516005770 putative active site [active] 632516005771 putative acetyltransferase; Provisional; Region: PRK03624 632516005772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632516005773 Coenzyme A binding pocket [chemical binding]; other site 632516005774 Uncharacterized conserved protein [Function unknown]; Region: COG0585 632516005775 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 632516005776 active site 632516005777 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 632516005778 Predicted methyltransferases [General function prediction only]; Region: COG1568 632516005779 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516005780 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 632516005781 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632516005782 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632516005783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632516005784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632516005785 DNA binding site [nucleotide binding] 632516005786 domain linker motif; other site 632516005787 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 632516005788 putative dimerization interface [polypeptide binding]; other site 632516005789 putative ligand binding site [chemical binding]; other site 632516005790 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632516005791 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632516005792 NAD(P) binding site [chemical binding]; other site 632516005793 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 632516005794 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 632516005795 substrate-cofactor binding pocket; other site 632516005796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516005797 catalytic residue [active] 632516005798 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 632516005799 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 632516005800 Potassium binding sites [ion binding]; other site 632516005801 Cesium cation binding sites [ion binding]; other site 632516005802 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 632516005803 active site 1 [active] 632516005804 active site 2 [active] 632516005805 Predicted permeases [General function prediction only]; Region: COG0730 632516005806 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 632516005807 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632516005808 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632516005809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632516005810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632516005811 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 632516005812 ApbE family; Region: ApbE; pfam02424 632516005813 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 632516005814 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 632516005815 homodimer interface [polypeptide binding]; other site 632516005816 substrate-cofactor binding pocket; other site 632516005817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516005818 catalytic residue [active] 632516005819 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 632516005820 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 632516005821 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 632516005822 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 632516005823 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 632516005824 glutamine binding [chemical binding]; other site 632516005825 catalytic triad [active] 632516005826 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632516005827 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632516005828 active site 632516005829 catalytic tetrad [active] 632516005830 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 632516005831 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 632516005832 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632516005833 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 632516005834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632516005835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632516005836 DNA binding site [nucleotide binding] 632516005837 domain linker motif; other site 632516005838 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632516005839 ligand binding site [chemical binding]; other site 632516005840 dimerization interface [polypeptide binding]; other site 632516005841 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516005842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516005843 dimer interface [polypeptide binding]; other site 632516005844 conserved gate region; other site 632516005845 putative PBP binding loops; other site 632516005846 ABC-ATPase subunit interface; other site 632516005847 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632516005848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516005849 putative PBP binding loops; other site 632516005850 dimer interface [polypeptide binding]; other site 632516005851 ABC-ATPase subunit interface; other site 632516005852 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516005853 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516005854 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 632516005855 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 632516005856 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632516005857 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 632516005858 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 632516005859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516005860 motif II; other site 632516005861 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 632516005862 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 632516005863 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 632516005864 Substrate binding site; other site 632516005865 Cupin domain; Region: Cupin_2; cl17218 632516005866 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 632516005867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516005868 S-adenosylmethionine binding site [chemical binding]; other site 632516005869 Preprotein translocase subunit; Region: YajC; pfam02699 632516005870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516005871 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632516005872 FeS/SAM binding site; other site 632516005873 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 632516005874 Predicted membrane protein [Function unknown]; Region: COG2246 632516005875 GtrA-like protein; Region: GtrA; pfam04138 632516005876 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 632516005877 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 632516005878 Ligand binding site; other site 632516005879 Putative Catalytic site; other site 632516005880 DXD motif; other site 632516005881 Transposase domain (DUF772); Region: DUF772; pfam05598 632516005882 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632516005883 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 632516005884 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 632516005885 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 632516005886 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 632516005887 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 632516005888 dimer interface [polypeptide binding]; other site 632516005889 substrate binding site [chemical binding]; other site 632516005890 ATP binding site [chemical binding]; other site 632516005891 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 632516005892 ThiC family; Region: ThiC; pfam01964 632516005893 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 632516005894 thiamine phosphate binding site [chemical binding]; other site 632516005895 active site 632516005896 pyrophosphate binding site [ion binding]; other site 632516005897 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 632516005898 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 632516005899 ATP binding site [chemical binding]; other site 632516005900 substrate interface [chemical binding]; other site 632516005901 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 632516005902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516005903 FeS/SAM binding site; other site 632516005904 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 632516005905 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 632516005906 ThiS interaction site; other site 632516005907 putative active site [active] 632516005908 tetramer interface [polypeptide binding]; other site 632516005909 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 632516005910 thiS-thiF/thiG interaction site; other site 632516005911 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 632516005912 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 632516005913 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 632516005914 Hpr binding site; other site 632516005915 active site 632516005916 homohexamer subunit interaction site [polypeptide binding]; other site 632516005917 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 632516005918 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 632516005919 GIY-YIG motif/motif A; other site 632516005920 active site 632516005921 catalytic site [active] 632516005922 putative DNA binding site [nucleotide binding]; other site 632516005923 metal binding site [ion binding]; metal-binding site 632516005924 UvrB/uvrC motif; Region: UVR; pfam02151 632516005925 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 632516005926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 632516005927 YbbR-like protein; Region: YbbR; pfam07949 632516005928 Uncharacterized conserved protein [Function unknown]; Region: COG1624 632516005929 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 632516005930 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 632516005931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516005932 FeS/SAM binding site; other site 632516005933 hypothetical protein; Provisional; Region: PRK03881 632516005934 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 632516005935 AMMECR1; Region: AMMECR1; pfam01871 632516005936 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632516005937 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632516005938 AP (apurinic/apyrimidinic) site pocket; other site 632516005939 DNA interaction; other site 632516005940 Metal-binding active site; metal-binding site 632516005941 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632516005942 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632516005943 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632516005944 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632516005945 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632516005946 DNA binding site [nucleotide binding] 632516005947 domain linker motif; other site 632516005948 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 632516005949 dimerization interface [polypeptide binding]; other site 632516005950 ligand binding site [chemical binding]; other site 632516005951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516005952 putative substrate translocation pore; other site 632516005953 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632516005954 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 632516005955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516005956 FeS/SAM binding site; other site 632516005957 Part of AAA domain; Region: AAA_19; pfam13245 632516005958 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632516005959 Family description; Region: UvrD_C_2; pfam13538 632516005960 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 632516005961 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 632516005962 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632516005963 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632516005964 Walker A/P-loop; other site 632516005965 ATP binding site [chemical binding]; other site 632516005966 Q-loop/lid; other site 632516005967 ABC transporter signature motif; other site 632516005968 Walker B; other site 632516005969 D-loop; other site 632516005970 H-loop/switch region; other site 632516005971 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 632516005972 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 632516005973 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 632516005974 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 632516005975 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 632516005976 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 632516005977 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 632516005978 HlyD family secretion protein; Region: HlyD_3; pfam13437 632516005979 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 632516005980 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 632516005981 putative active site [active] 632516005982 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516005983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516005984 Walker A/P-loop; other site 632516005985 ATP binding site [chemical binding]; other site 632516005986 Q-loop/lid; other site 632516005987 ABC transporter signature motif; other site 632516005988 Walker B; other site 632516005989 D-loop; other site 632516005990 H-loop/switch region; other site 632516005991 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 632516005992 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 632516005993 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 632516005994 FAD binding site [chemical binding]; other site 632516005995 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 632516005996 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 632516005997 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 632516005998 regulatory protein interface [polypeptide binding]; other site 632516005999 active site 632516006000 regulatory phosphorylation site [posttranslational modification]; other site 632516006001 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 632516006002 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 632516006003 Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048 632516006004 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 632516006005 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 632516006006 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 632516006007 phosphate binding site [ion binding]; other site 632516006008 putative substrate binding pocket [chemical binding]; other site 632516006009 dimer interface [polypeptide binding]; other site 632516006010 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 632516006011 shikimate kinase; Reviewed; Region: aroK; PRK00131 632516006012 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 632516006013 FAD binding domain; Region: FAD_binding_4; pfam01565 632516006014 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 632516006015 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 632516006016 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 632516006017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516006018 active site 632516006019 motif I; other site 632516006020 motif II; other site 632516006021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632516006022 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632516006023 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516006024 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632516006025 dimerization interface [polypeptide binding]; other site 632516006026 putative DNA binding site [nucleotide binding]; other site 632516006027 putative Zn2+ binding site [ion binding]; other site 632516006028 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632516006029 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632516006030 metal-binding site [ion binding] 632516006031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632516006032 Soluble P-type ATPase [General function prediction only]; Region: COG4087 632516006033 Bifunctional nuclease; Region: DNase-RNase; pfam02577 632516006034 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 632516006035 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 632516006036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516006037 FeS/SAM binding site; other site 632516006038 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 632516006039 active site 632516006040 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 632516006041 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 632516006042 active site 632516006043 HIGH motif; other site 632516006044 KMSKS motif; other site 632516006045 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 632516006046 tRNA binding surface [nucleotide binding]; other site 632516006047 anticodon binding site; other site 632516006048 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 632516006049 dimer interface [polypeptide binding]; other site 632516006050 putative tRNA-binding site [nucleotide binding]; other site 632516006051 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 632516006052 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 632516006053 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 632516006054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516006055 active site 632516006056 phosphorylation site [posttranslational modification] 632516006057 intermolecular recognition site; other site 632516006058 dimerization interface [polypeptide binding]; other site 632516006059 CheB methylesterase; Region: CheB_methylest; pfam01339 632516006060 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 632516006061 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 632516006062 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 632516006063 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 632516006064 Probable transposase; Region: OrfB_IS605; pfam01385 632516006065 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516006066 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632516006067 Transposase IS200 like; Region: Y1_Tnp; pfam01797 632516006068 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632516006069 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632516006070 Walker A/P-loop; other site 632516006071 ATP binding site [chemical binding]; other site 632516006072 Q-loop/lid; other site 632516006073 ABC transporter signature motif; other site 632516006074 Walker B; other site 632516006075 D-loop; other site 632516006076 H-loop/switch region; other site 632516006077 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 632516006078 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632516006079 ABC-ATPase subunit interface; other site 632516006080 dimer interface [polypeptide binding]; other site 632516006081 putative PBP binding regions; other site 632516006082 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632516006083 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 632516006084 putative metal binding site [ion binding]; other site 632516006085 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 632516006086 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632516006087 dimerization interface [polypeptide binding]; other site 632516006088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632516006089 dimer interface [polypeptide binding]; other site 632516006090 phosphorylation site [posttranslational modification] 632516006091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516006092 ATP binding site [chemical binding]; other site 632516006093 Mg2+ binding site [ion binding]; other site 632516006094 G-X-G motif; other site 632516006095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632516006096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516006097 active site 632516006098 phosphorylation site [posttranslational modification] 632516006099 intermolecular recognition site; other site 632516006100 dimerization interface [polypeptide binding]; other site 632516006101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632516006102 DNA binding site [nucleotide binding] 632516006103 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 632516006104 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632516006105 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632516006106 Probable transposase; Region: OrfB_IS605; pfam01385 632516006107 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516006108 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 632516006109 iron binding site [ion binding]; other site 632516006110 Transposase IS200 like; Region: Y1_Tnp; pfam01797 632516006111 4Fe-4S binding domain; Region: Fer4_5; pfam12801 632516006112 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 632516006113 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632516006114 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632516006115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516006116 active site 632516006117 phosphorylation site [posttranslational modification] 632516006118 intermolecular recognition site; other site 632516006119 dimerization interface [polypeptide binding]; other site 632516006120 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632516006121 DNA binding site [nucleotide binding] 632516006122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632516006123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632516006124 dimerization interface [polypeptide binding]; other site 632516006125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632516006126 dimer interface [polypeptide binding]; other site 632516006127 phosphorylation site [posttranslational modification] 632516006128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516006129 ATP binding site [chemical binding]; other site 632516006130 Mg2+ binding site [ion binding]; other site 632516006131 G-X-G motif; other site 632516006132 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 632516006133 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 632516006134 active site 632516006135 metal binding site [ion binding]; metal-binding site 632516006136 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 632516006137 TIGR02680 family protein; Region: TIGR02680 632516006138 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 632516006139 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 632516006140 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 632516006141 TIGR02677 family protein; Region: TIGR02677 632516006142 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 632516006143 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 632516006144 Stage II sporulation protein; Region: SpoIID; pfam08486 632516006145 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 632516006146 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 632516006147 TrkA-N domain; Region: TrkA_N; pfam02254 632516006148 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 632516006149 TrkA-N domain; Region: TrkA_N; pfam02254 632516006150 TrkA-C domain; Region: TrkA_C; pfam02080 632516006151 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 632516006152 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 632516006153 Predicted integral membrane protein [Function unknown]; Region: COG5652 632516006154 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 632516006155 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 632516006156 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 632516006157 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 632516006158 active site 632516006159 Substrate binding site; other site 632516006160 Mg++ binding site; other site 632516006161 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632516006162 putative trimer interface [polypeptide binding]; other site 632516006163 putative CoA binding site [chemical binding]; other site 632516006164 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 632516006165 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 632516006166 active site 632516006167 metal binding site [ion binding]; metal-binding site 632516006168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516006169 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632516006170 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 632516006171 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 632516006172 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 632516006173 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 632516006174 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 632516006175 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 632516006176 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516006177 NAD synthetase; Provisional; Region: PRK13981 632516006178 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 632516006179 multimer interface [polypeptide binding]; other site 632516006180 active site 632516006181 catalytic triad [active] 632516006182 protein interface 1 [polypeptide binding]; other site 632516006183 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 632516006184 homodimer interface [polypeptide binding]; other site 632516006185 NAD binding pocket [chemical binding]; other site 632516006186 ATP binding pocket [chemical binding]; other site 632516006187 Mg binding site [ion binding]; other site 632516006188 active-site loop [active] 632516006189 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 632516006190 stage II sporulation protein D; Region: spore_II_D; TIGR02870 632516006191 Stage II sporulation protein; Region: SpoIID; pfam08486 632516006192 stage II sporulation protein E; Region: spore_II_E; TIGR02865 632516006193 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 632516006194 phage shock protein A; Region: phageshock_pspA; TIGR02977 632516006195 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632516006196 putative active site [active] 632516006197 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 632516006198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632516006199 NAD(P) binding site [chemical binding]; other site 632516006200 active site 632516006201 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 632516006202 catalytic center binding site [active] 632516006203 ATP binding site [chemical binding]; other site 632516006204 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 632516006205 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 632516006206 dihydropteroate synthase; Region: DHPS; TIGR01496 632516006207 substrate binding pocket [chemical binding]; other site 632516006208 dimer interface [polypeptide binding]; other site 632516006209 inhibitor binding site; inhibition site 632516006210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632516006211 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 632516006212 dimerization interface [polypeptide binding]; other site 632516006213 putative DNA binding site [nucleotide binding]; other site 632516006214 putative Zn2+ binding site [ion binding]; other site 632516006215 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 632516006216 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 632516006217 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632516006218 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632516006219 hinge; other site 632516006220 active site 632516006221 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 632516006222 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632516006223 dimer interface [polypeptide binding]; other site 632516006224 putative CheW interface [polypeptide binding]; other site 632516006225 PemK-like protein; Region: PemK; pfam02452 632516006226 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632516006227 Helix-turn-helix domain; Region: HTH_38; pfam13936 632516006228 Integrase core domain; Region: rve; pfam00665 632516006229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516006230 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632516006231 Walker A motif; other site 632516006232 ATP binding site [chemical binding]; other site 632516006233 Walker B motif; other site 632516006234 arginine finger; other site 632516006235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 632516006236 Integrase core domain; Region: rve; pfam00665 632516006237 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632516006238 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632516006239 putative DNA binding site [nucleotide binding]; other site 632516006240 putative Zn2+ binding site [ion binding]; other site 632516006241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632516006242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632516006243 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 632516006244 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 632516006245 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 632516006246 ACS interaction site; other site 632516006247 CODH interaction site; other site 632516006248 metal cluster binding site [ion binding]; other site 632516006249 Rrf2 family protein; Region: rrf2_super; TIGR00738 632516006250 Transcriptional regulator; Region: Rrf2; pfam02082 632516006251 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 632516006252 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 632516006253 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632516006254 nucleotide binding site [chemical binding]; other site 632516006255 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 632516006256 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 632516006257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516006258 FeS/SAM binding site; other site 632516006259 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 632516006260 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 632516006261 Ligand Binding Site [chemical binding]; other site 632516006262 TIGR00269 family protein; Region: TIGR00269 632516006263 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104 632516006264 charged pocket; other site 632516006265 hydrophobic patch; other site 632516006266 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 632516006267 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 632516006268 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 632516006269 homotrimer interaction site [polypeptide binding]; other site 632516006270 putative active site [active] 632516006271 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 632516006272 Ligand Binding Site [chemical binding]; other site 632516006273 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632516006274 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632516006275 G5 domain; Region: G5; pfam07501 632516006276 Peptidase family M23; Region: Peptidase_M23; pfam01551 632516006277 Carbohydrate binding module 27; Region: CBM27; pfam09212 632516006278 Carbohydrate binding module 27; Region: CBM27; pfam09212 632516006279 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632516006280 putative metal binding site [ion binding]; other site 632516006281 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 632516006282 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516006283 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516006284 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516006285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516006286 dimer interface [polypeptide binding]; other site 632516006287 conserved gate region; other site 632516006288 putative PBP binding loops; other site 632516006289 ABC-ATPase subunit interface; other site 632516006290 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632516006291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632516006292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516006293 ABC-ATPase subunit interface; other site 632516006294 putative PBP binding loops; other site 632516006295 NHL repeat; Region: NHL; pfam01436 632516006296 Uncharacterized conserved protein [Function unknown]; Region: COG3391 632516006297 NHL repeat; Region: NHL; pfam01436 632516006298 Tetratricopeptide repeat; Region: TPR_16; pfam13432 632516006299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632516006300 TPR motif; other site 632516006301 binding surface 632516006302 Yip1 domain; Region: Yip1; pfam04893 632516006303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516006304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516006305 dimer interface [polypeptide binding]; other site 632516006306 conserved gate region; other site 632516006307 putative PBP binding loops; other site 632516006308 ABC-ATPase subunit interface; other site 632516006309 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632516006310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516006311 dimer interface [polypeptide binding]; other site 632516006312 conserved gate region; other site 632516006313 putative PBP binding loops; other site 632516006314 ABC-ATPase subunit interface; other site 632516006315 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632516006316 putative metal binding site [ion binding]; other site 632516006317 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 632516006318 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632516006319 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516006320 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632516006321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632516006322 DNA binding site [nucleotide binding] 632516006323 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632516006324 Carbohydrate binding module 27; Region: CBM27; pfam09212 632516006325 Carbohydrate binding module 27; Region: CBM27; pfam09212 632516006326 Carbohydrate binding module 27; Region: CBM27; pfam09212 632516006327 S-layer homology domain; Region: SLH; pfam00395 632516006328 S-layer homology domain; Region: SLH; pfam00395 632516006329 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 632516006330 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 632516006331 Predicted methyltransferases [General function prediction only]; Region: COG0313 632516006332 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 632516006333 putative SAM binding site [chemical binding]; other site 632516006334 putative homodimer interface [polypeptide binding]; other site 632516006335 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 632516006336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516006337 S-adenosylmethionine binding site [chemical binding]; other site 632516006338 Response regulator receiver domain; Region: Response_reg; pfam00072 632516006339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516006340 active site 632516006341 phosphorylation site [posttranslational modification] 632516006342 intermolecular recognition site; other site 632516006343 dimerization interface [polypeptide binding]; other site 632516006344 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 632516006345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516006346 FeS/SAM binding site; other site 632516006347 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 632516006348 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 632516006349 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 632516006350 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 632516006351 active site 632516006352 membrane protein; Provisional; Region: PRK14404 632516006353 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 632516006354 Transposase domain (DUF772); Region: DUF772; pfam05598 632516006355 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 632516006356 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 632516006357 Ca binding site [ion binding]; other site 632516006358 active site 632516006359 catalytic site [active] 632516006360 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632516006361 metal binding site 2 [ion binding]; metal-binding site 632516006362 putative DNA binding helix; other site 632516006363 metal binding site 1 [ion binding]; metal-binding site 632516006364 dimer interface [polypeptide binding]; other site 632516006365 structural Zn2+ binding site [ion binding]; other site 632516006366 Rubrerythrin [Energy production and conversion]; Region: COG1592 632516006367 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 632516006368 binuclear metal center [ion binding]; other site 632516006369 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 632516006370 iron binding site [ion binding]; other site 632516006371 Short C-terminal domain; Region: SHOCT; pfam09851 632516006372 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 632516006373 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516006374 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516006375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516006376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516006377 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516006378 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516006379 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516006380 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 632516006381 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 632516006382 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632516006383 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 632516006384 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 632516006385 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 632516006386 putative substrate binding site [chemical binding]; other site 632516006387 putative ATP binding site [chemical binding]; other site 632516006388 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632516006389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632516006390 DNA-binding site [nucleotide binding]; DNA binding site 632516006391 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632516006392 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 632516006393 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 632516006394 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 632516006395 homodimer interface [polypeptide binding]; other site 632516006396 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 632516006397 active site 632516006398 catalytic site [active] 632516006399 maltose binding site 2 [chemical binding]; other site 632516006400 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632516006401 Helix-turn-helix domain; Region: HTH_38; pfam13936 632516006402 Integrase core domain; Region: rve; pfam00665 632516006403 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 632516006404 4Fe-4S binding domain; Region: Fer4; cl02805 632516006405 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 632516006406 Putative Fe-S cluster; Region: FeS; cl17515 632516006407 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 632516006408 dimer interface [polypeptide binding]; other site 632516006409 putative CheW interface [polypeptide binding]; other site 632516006410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 632516006411 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 632516006412 Integrase core domain; Region: rve; pfam00665 632516006413 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 632516006414 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632516006415 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632516006416 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632516006417 DNA binding site [nucleotide binding] 632516006418 domain linker motif; other site 632516006419 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 632516006420 putative dimerization interface [polypeptide binding]; other site 632516006421 putative ligand binding site [chemical binding]; other site 632516006422 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632516006423 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 632516006424 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632516006425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516006426 dimer interface [polypeptide binding]; other site 632516006427 conserved gate region; other site 632516006428 putative PBP binding loops; other site 632516006429 ABC-ATPase subunit interface; other site 632516006430 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632516006431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632516006432 putative PBP binding loops; other site 632516006433 ABC-ATPase subunit interface; other site 632516006434 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 632516006435 homodimer interface [polypeptide binding]; other site 632516006436 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 632516006437 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 632516006438 active site 632516006439 homodimer interface [polypeptide binding]; other site 632516006440 catalytic site [active] 632516006441 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 632516006442 intersubunit interface [polypeptide binding]; other site 632516006443 active site 632516006444 Zn2+ binding site [ion binding]; other site 632516006445 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 632516006446 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 632516006447 B12 binding site [chemical binding]; other site 632516006448 cobalt ligand [ion binding]; other site 632516006449 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 632516006450 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 632516006451 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632516006452 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632516006453 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 632516006454 HlyD family secretion protein; Region: HlyD_3; pfam13437 632516006455 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632516006456 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632516006457 Walker A/P-loop; other site 632516006458 ATP binding site [chemical binding]; other site 632516006459 Q-loop/lid; other site 632516006460 ABC transporter signature motif; other site 632516006461 Walker B; other site 632516006462 D-loop; other site 632516006463 H-loop/switch region; other site 632516006464 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632516006465 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632516006466 FtsX-like permease family; Region: FtsX; pfam02687 632516006467 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 632516006468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516006469 S-adenosylmethionine binding site [chemical binding]; other site 632516006470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516006471 S-adenosylmethionine binding site [chemical binding]; other site 632516006472 trehalose synthase; Region: treS_nterm; TIGR02456 632516006473 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 632516006474 Ca binding site [ion binding]; other site 632516006475 active site 632516006476 catalytic site [active] 632516006477 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632516006478 putative active site [active] 632516006479 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 632516006480 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 632516006481 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 632516006482 polymerase nucleotide-binding site; other site 632516006483 DNA-binding residues [nucleotide binding]; DNA binding site 632516006484 nucleotide binding site [chemical binding]; other site 632516006485 primase nucleotide-binding site [nucleotide binding]; other site 632516006486 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 632516006487 DNA binding domain, excisionase family; Region: excise; TIGR01764 632516006488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632516006489 sequence-specific DNA binding site [nucleotide binding]; other site 632516006490 salt bridge; other site 632516006491 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632516006492 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632516006493 active site 632516006494 DNA binding site [nucleotide binding] 632516006495 Int/Topo IB signature motif; other site 632516006496 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 632516006497 Ligand Binding Site [chemical binding]; other site 632516006498 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 632516006499 Iron permease FTR1 family; Region: FTR1; cl00475 632516006500 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 632516006501 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 632516006502 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632516006503 Protein of unknown function (DUF970); Region: DUF970; cl17525 632516006504 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 632516006505 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 632516006506 Walker A/P-loop; other site 632516006507 ATP binding site [chemical binding]; other site 632516006508 Q-loop/lid; other site 632516006509 ABC transporter signature motif; other site 632516006510 Walker B; other site 632516006511 D-loop; other site 632516006512 H-loop/switch region; other site 632516006513 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 632516006514 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 632516006515 SurA N-terminal domain; Region: SurA_N_3; cl07813 632516006516 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632516006517 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 632516006518 FtsX-like permease family; Region: FtsX; pfam02687 632516006519 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 632516006520 HlyD family secretion protein; Region: HlyD_3; pfam13437 632516006521 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632516006522 carboxyltransferase (CT) interaction site; other site 632516006523 biotinylation site [posttranslational modification]; other site 632516006524 HlyD family secretion protein; Region: HlyD_3; pfam13437 632516006525 Yip1 domain; Region: Yip1; pfam04893 632516006526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632516006527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516006528 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 632516006529 Walker A/P-loop; other site 632516006530 ATP binding site [chemical binding]; other site 632516006531 Q-loop/lid; other site 632516006532 ABC transporter signature motif; other site 632516006533 Walker B; other site 632516006534 D-loop; other site 632516006535 H-loop/switch region; other site 632516006536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632516006537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632516006538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516006539 Walker A/P-loop; other site 632516006540 ATP binding site [chemical binding]; other site 632516006541 Q-loop/lid; other site 632516006542 ABC transporter signature motif; other site 632516006543 Walker B; other site 632516006544 D-loop; other site 632516006545 H-loop/switch region; other site 632516006546 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632516006547 MarR family; Region: MarR; pfam01047 632516006548 Protein of unknown function (DUF554); Region: DUF554; pfam04474 632516006549 YycH protein; Region: YycI; cl02015 632516006550 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632516006551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632516006552 Walker A/P-loop; other site 632516006553 ATP binding site [chemical binding]; other site 632516006554 Q-loop/lid; other site 632516006555 ABC transporter signature motif; other site 632516006556 Walker B; other site 632516006557 D-loop; other site 632516006558 H-loop/switch region; other site 632516006559 VID27 cytoplasmic protein; Region: VID27; pfam08553 632516006560 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632516006561 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 632516006562 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 632516006563 Peptidase family M48; Region: Peptidase_M48; cl12018 632516006564 Histidine kinase; Region: HisKA_3; pfam07730 632516006565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516006566 ATP binding site [chemical binding]; other site 632516006567 Mg2+ binding site [ion binding]; other site 632516006568 G-X-G motif; other site 632516006569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632516006570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516006571 active site 632516006572 phosphorylation site [posttranslational modification] 632516006573 intermolecular recognition site; other site 632516006574 dimerization interface [polypeptide binding]; other site 632516006575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632516006576 DNA binding residues [nucleotide binding] 632516006577 dimerization interface [polypeptide binding]; other site 632516006578 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 632516006579 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 632516006580 DNA binding residues [nucleotide binding] 632516006581 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 632516006582 catalytic residues [active] 632516006583 catalytic nucleophile [active] 632516006584 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632516006585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516006586 S-adenosylmethionine binding site [chemical binding]; other site 632516006587 PIN domain; Region: PIN_3; pfam13470 632516006588 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 632516006589 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632516006590 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 632516006591 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632516006592 Catalytic site [active] 632516006593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516006594 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516006595 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516006596 S-layer homology domain; Region: SLH; pfam00395 632516006597 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632516006598 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632516006599 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632516006600 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632516006601 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632516006602 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632516006603 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 632516006604 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 632516006605 Beta propeller domain; Region: Beta_propel; pfam09826 632516006606 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 632516006607 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 632516006608 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 632516006609 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 632516006610 Asp-box motif; other site 632516006611 catalytic site [active] 632516006612 Cellulose binding domain; Region: CBM_3; pfam00942 632516006613 Cellulose binding domain; Region: CBM_3; cl03026 632516006614 Cellulose binding domain; Region: CBM_3; cl03026 632516006615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516006616 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516006617 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516006618 Transposase domain (DUF772); Region: DUF772; pfam05598 632516006619 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 632516006620 metal binding site [ion binding]; metal-binding site 632516006621 active site 632516006622 Cellulose binding domain; Region: CBM_3; pfam00942 632516006623 Cellulose binding domain; Region: CBM_3; cl03026 632516006624 Cellulose binding domain; Region: CBM_3; cl03026 632516006625 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 632516006626 YycH protein; Region: YycI; cl02015 632516006627 YycH protein; Region: YycH; pfam07435 632516006628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 632516006629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632516006630 dimerization interface [polypeptide binding]; other site 632516006631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 632516006632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632516006633 dimer interface [polypeptide binding]; other site 632516006634 phosphorylation site [posttranslational modification] 632516006635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632516006636 ATP binding site [chemical binding]; other site 632516006637 Mg2+ binding site [ion binding]; other site 632516006638 G-X-G motif; other site 632516006639 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632516006640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632516006641 active site 632516006642 phosphorylation site [posttranslational modification] 632516006643 intermolecular recognition site; other site 632516006644 dimerization interface [polypeptide binding]; other site 632516006645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632516006646 DNA binding site [nucleotide binding] 632516006647 CTP synthetase; Validated; Region: pyrG; PRK05380 632516006648 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 632516006649 Catalytic site [active] 632516006650 active site 632516006651 UTP binding site [chemical binding]; other site 632516006652 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 632516006653 active site 632516006654 putative oxyanion hole; other site 632516006655 catalytic triad [active] 632516006656 S-layer homology domain; Region: SLH; pfam00395 632516006657 S-layer homology domain; Region: SLH; pfam00395 632516006658 S-layer homology domain; Region: SLH; pfam00395 632516006659 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 632516006660 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 632516006661 Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907 632516006662 ADP-ribose binding site [chemical binding]; other site 632516006663 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 632516006664 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 632516006665 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632516006666 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 632516006667 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 632516006668 NAD binding site [chemical binding]; other site 632516006669 substrate binding site [chemical binding]; other site 632516006670 homodimer interface [polypeptide binding]; other site 632516006671 active site 632516006672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632516006673 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632516006674 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632516006675 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 632516006676 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 632516006677 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 632516006678 substrate binding site; other site 632516006679 tetramer interface; other site 632516006680 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632516006681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516006682 S-adenosylmethionine binding site [chemical binding]; other site 632516006683 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 632516006684 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 632516006685 Probable Catalytic site; other site 632516006686 metal-binding site 632516006687 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516006688 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632516006689 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632516006690 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 632516006691 putative ADP-binding pocket [chemical binding]; other site 632516006692 O-Antigen ligase; Region: Wzy_C; pfam04932 632516006693 O-Antigen ligase; Region: Wzy_C; cl04850 632516006694 TPR repeat; Region: TPR_11; pfam13414 632516006695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632516006696 binding surface 632516006697 TPR motif; other site 632516006698 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632516006699 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 632516006700 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 632516006701 Integral membrane protein DUF95; Region: DUF95; pfam01944 632516006702 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 632516006703 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632516006704 active site 632516006705 catalytic tetrad [active] 632516006706 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 632516006707 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 632516006708 GDP-binding site [chemical binding]; other site 632516006709 ACT binding site; other site 632516006710 IMP binding site; other site 632516006711 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632516006712 metal ion-dependent adhesion site (MIDAS); other site 632516006713 von Willebrand factor type A domain; Region: VWA_2; pfam13519 632516006714 metal ion-dependent adhesion site (MIDAS); other site 632516006715 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 632516006716 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 632516006717 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632516006718 metal ion-dependent adhesion site (MIDAS); other site 632516006719 Protein of unknown function DUF58; Region: DUF58; pfam01882 632516006720 MoxR-like ATPases [General function prediction only]; Region: COG0714 632516006721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632516006722 Walker A motif; other site 632516006723 ATP binding site [chemical binding]; other site 632516006724 Walker B motif; other site 632516006725 arginine finger; other site 632516006726 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 632516006727 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632516006728 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632516006729 Walker A/P-loop; other site 632516006730 ATP binding site [chemical binding]; other site 632516006731 Q-loop/lid; other site 632516006732 ABC transporter signature motif; other site 632516006733 Walker B; other site 632516006734 D-loop; other site 632516006735 H-loop/switch region; other site 632516006736 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 632516006737 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632516006738 putative active site [active] 632516006739 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 632516006740 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 632516006741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516006742 ATP binding site [chemical binding]; other site 632516006743 putative Mg++ binding site [ion binding]; other site 632516006744 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 632516006745 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632516006746 nucleotide binding region [chemical binding]; other site 632516006747 ATP-binding site [chemical binding]; other site 632516006748 Repair protein; Region: Repair_PSII; pfam04536 632516006749 LemA family; Region: LemA; pfam04011 632516006750 KWG Leptospira; Region: KWG; pfam07656 632516006751 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 632516006752 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 632516006753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632516006754 catalytic residue [active] 632516006755 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 632516006756 PLD-like domain; Region: PLDc_2; pfam13091 632516006757 putative homodimer interface [polypeptide binding]; other site 632516006758 putative active site [active] 632516006759 catalytic site [active] 632516006760 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632516006761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632516006762 ATP binding site [chemical binding]; other site 632516006763 putative Mg++ binding site [ion binding]; other site 632516006764 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632516006765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632516006766 S-adenosylmethionine binding site [chemical binding]; other site 632516006767 peroxiredoxin; Provisional; Region: PRK13189 632516006768 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 632516006769 dimer interface [polypeptide binding]; other site 632516006770 decamer (pentamer of dimers) interface [polypeptide binding]; other site 632516006771 catalytic triad [active] 632516006772 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 632516006773 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632516006774 Family description; Region: UvrD_C_2; pfam13538 632516006775 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 632516006776 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632516006777 Catalytic site [active] 632516006778 Beta propeller domain; Region: Beta_propel; pfam09826 632516006779 Archaeal ATPase; Region: Arch_ATPase; pfam01637 632516006780 AAA ATPase domain; Region: AAA_16; pfam13191 632516006781 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 632516006782 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 632516006783 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 632516006784 S-layer homology domain; Region: SLH; pfam00395 632516006785 S-layer homology domain; Region: SLH; pfam00395 632516006786 S-layer homology domain; Region: SLH; pfam00395 632516006787 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 632516006788 Helix-turn-helix domain; Region: HTH_18; pfam12833 632516006789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632516006790 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 632516006791 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 632516006792 putative active site [active] 632516006793 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 632516006794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516006795 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632516006796 putative substrate translocation pore; other site 632516006797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516006798 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 632516006799 biotin synthase; Provisional; Region: PRK07094 632516006800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632516006801 FeS/SAM binding site; other site 632516006802 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 632516006803 Transglycosylase; Region: Transgly; pfam00912 632516006804 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 632516006805 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632516006806 endoglucanase; Region: PLN02420 632516006807 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 632516006808 Cellulose binding domain; Region: CBM_3; pfam00942 632516006809 Cellulose binding domain; Region: CBM_3; pfam00942 632516006810 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 632516006811 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632516006812 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 632516006813 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 632516006814 nucleotide binding site [chemical binding]; other site 632516006815 putative NEF/HSP70 interaction site [polypeptide binding]; other site 632516006816 SBD interface [polypeptide binding]; other site 632516006817 Protein of unknown function (DUF904); Region: DUF904; pfam06005 632516006818 hypothetical protein; Provisional; Region: PRK09956 632516006819 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 632516006820 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 632516006821 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 632516006822 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 632516006823 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 632516006824 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632516006825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 632516006826 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 632516006827 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 632516006828 Family of unknown function (DUF694); Region: DUF694; pfam05107 632516006829 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730 632516006830 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 632516006831 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 632516006832 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 632516006833 toxin interface [polypeptide binding]; other site 632516006834 Zn binding site [ion binding]; other site 632516006835 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 632516006836 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 632516006837 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 632516006838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632516006839 putative substrate translocation pore; other site 632516006840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632516006841 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 632516006842 HerA helicase [Replication, recombination, and repair]; Region: COG0433 632516006843 Domain of unknown function DUF87; Region: DUF87; pfam01935 632516006844 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 632516006845 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 632516006846 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 632516006847 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 632516006848 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 632516006849 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 632516006850 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 632516006851 Zeta toxin; Region: Zeta_toxin; pfam06414 632516006852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 632516006853 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 632516006854 CRISPR-associated protein, MJ1666 family; Region: cas_MJ1666; TIGR01897 632516006855 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 632516006856 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 632516006857 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 632516006858 active site 632516006859 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 632516006860 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 632516006861 HicB family; Region: HicB; pfam05534 632516006862 YcfA-like protein; Region: YcfA; cl00752 632516006863 BioY family; Region: BioY; pfam02632 632516006864 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 632516006865 AAA domain; Region: AAA_30; pfam13604 632516006866 Family description; Region: UvrD_C_2; pfam13538 632516006867 YvrJ protein family; Region: YvrJ; pfam12841 632516006868 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 632516006869 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 632516006870 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 632516006871 stage V sporulation protein AD; Validated; Region: PRK08304 632516006872 stage V sporulation protein AD; Provisional; Region: PRK12404 632516006873 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 632516006874 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 632516006875 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 632516006876 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 632516006877 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 632516006878 Family of unknown function (DUF694); Region: DUF694; pfam05107 632516006879 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 632516006880 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 632516006881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 632516006882 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 632516006883 Archaeal ATPase; Region: Arch_ATPase; pfam01637 632516006884 AAA domain; Region: AAA_14; pfam13173 632516006885 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 632516006886 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 632516006887 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 632516006888 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 632516006889 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 632516006890 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 632516006891 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 632516006892 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 632516006893 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 632516006894 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 632516006895 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632516006896 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632516006897 substrate binding pocket [chemical binding]; other site 632516006898 membrane-bound complex binding site; other site 632516006899 hinge residues; other site 632516006900 PAS fold; Region: PAS; pfam00989 632516006901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632516006902 putative active site [active] 632516006903 heme pocket [chemical binding]; other site 632516006904 PAS fold; Region: PAS_3; pfam08447 632516006905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632516006906 heme pocket [chemical binding]; other site 632516006907 putative active site [active] 632516006908 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632516006909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632516006910 metal binding site [ion binding]; metal-binding site 632516006911 active site 632516006912 I-site; other site 632516006913 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 632516006914 WYL domain; Region: WYL; pfam13280 632516006915 WYL domain; Region: WYL; pfam13280 632516006916 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 632516006917 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 632516006918 fumarate hydratase; Provisional; Region: PRK06246 632516006919 Colicin V production protein; Region: Colicin_V; pfam02674 632516006920 PAS fold; Region: PAS_4; pfam08448 632516006921 Protein of unknown function (DUF3629); Region: DUF3629; pfam12302 632516006922 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 632516006923 ParB-like nuclease domain; Region: ParB; smart00470 632516006924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 632516006925 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632516006926 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632516006927 P-loop; other site 632516006928 Magnesium ion binding site [ion binding]; other site 632516006929 Bacterial Ig-like domain; Region: Big_5; pfam13205 632516006930 PBP superfamily domain; Region: PBP_like_2; cl17296 632516006931 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632516006932 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 632516006933 dimer interface [polypeptide binding]; other site 632516006934 Alkaline phosphatase homologues; Region: alkPPc; smart00098 632516006935 active site 632516006936 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 632516006937 ParB-like nuclease domain; Region: ParB; smart00470 632516006938 KorB domain; Region: KorB; pfam08535 632516006939 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 632516006940 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 632516006941 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 632516006942 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 632516006943 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 632516006944 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 632516006945 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 632516006946 trmE is a tRNA modification GTPase; Region: trmE; cd04164 632516006947 G1 box; other site 632516006948 GTP/Mg2+ binding site [chemical binding]; other site 632516006949 Switch I region; other site 632516006950 G2 box; other site 632516006951 Switch II region; other site 632516006952 G3 box; other site 632516006953 G4 box; other site 632516006954 G5 box; other site 632516006955 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 632516006956 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 632516006957 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 632516006958 G-X-X-G motif; other site 632516006959 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 632516006960 RxxxH motif; other site 632516006961 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 632516006962 Haemolytic domain; Region: Haemolytic; pfam01809 632516006963 Ribonuclease P; Region: Ribonuclease_P; cl00457 632516006964 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 632516006965 Transposase domain (DUF772); Region: DUF772; pfam05598 632516006966 Transposase IS200 like; Region: Y1_Tnp; pfam01797 632516006967 Probable transposase; Region: OrfB_IS605; pfam01385 632516006968 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632516006969 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282