-- dump date   	20140619_020611
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
351627000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
351627000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
351627000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627000004	Walker A motif; other site
351627000005	ATP binding site [chemical binding]; other site
351627000006	Walker B motif; other site
351627000007	arginine finger; other site
351627000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
351627000009	DnaA box-binding interface [nucleotide binding]; other site
351627000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
351627000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
351627000012	putative DNA binding surface [nucleotide binding]; other site
351627000013	dimer interface [polypeptide binding]; other site
351627000014	beta-clamp/clamp loader binding surface; other site
351627000015	beta-clamp/translesion DNA polymerase binding surface; other site
351627000016	recombination protein F; Reviewed; Region: recF; PRK00064
351627000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627000018	Walker A/P-loop; other site
351627000019	ATP binding site [chemical binding]; other site
351627000020	Q-loop/lid; other site
351627000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627000022	ABC transporter signature motif; other site
351627000023	Walker B; other site
351627000024	D-loop; other site
351627000025	H-loop/switch region; other site
351627000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
351627000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627000028	ATP binding site [chemical binding]; other site
351627000029	Mg2+ binding site [ion binding]; other site
351627000030	G-X-G motif; other site
351627000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
351627000032	anchoring element; other site
351627000033	dimer interface [polypeptide binding]; other site
351627000034	ATP binding site [chemical binding]; other site
351627000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
351627000036	active site
351627000037	putative metal-binding site [ion binding]; other site
351627000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
351627000039	DNA gyrase subunit A; Validated; Region: PRK05560
351627000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
351627000041	CAP-like domain; other site
351627000042	active site
351627000043	primary dimer interface [polypeptide binding]; other site
351627000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351627000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351627000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351627000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351627000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351627000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
351627000050	Beta propeller domain; Region: Beta_propel; pfam09826
351627000051	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
351627000052	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627000053	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
351627000054	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
351627000055	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
351627000056	Predicted transcriptional regulator [Transcription]; Region: COG2378
351627000057	WYL domain; Region: WYL; pfam13280
351627000058	WYL domain; Region: WYL; pfam13280
351627000059	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351627000060	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627000061	S-adenosylmethionine binding site [chemical binding]; other site
351627000062	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205
351627000063	PLD-like domain; Region: PLDc_2; pfam13091
351627000064	putative homodimer interface [polypeptide binding]; other site
351627000065	putative active site [active]
351627000066	catalytic site [active]
351627000067	DEAD-like helicases superfamily; Region: DEXDc; smart00487
351627000068	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351627000069	ATP binding site [chemical binding]; other site
351627000070	putative Mg++ binding site [ion binding]; other site
351627000071	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351627000072	nucleotide binding region [chemical binding]; other site
351627000073	ATP-binding site [chemical binding]; other site
351627000074	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351627000075	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351627000076	substrate binding pocket [chemical binding]; other site
351627000077	membrane-bound complex binding site; other site
351627000078	hinge residues; other site
351627000079	PAS domain S-box; Region: sensory_box; TIGR00229
351627000080	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351627000081	putative active site [active]
351627000082	heme pocket [chemical binding]; other site
351627000083	PAS domain S-box; Region: sensory_box; TIGR00229
351627000084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
351627000085	heme pocket [chemical binding]; other site
351627000086	putative active site [active]
351627000087	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351627000088	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351627000089	metal binding site [ion binding]; metal-binding site
351627000090	active site
351627000091	I-site; other site
351627000092	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351627000093	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
351627000094	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
351627000095	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
351627000096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627000097	catalytic residue [active]
351627000098	potential frameshift: common BLAST hit: gi|312126279|ref|YP_003991153.1| kwg leptospira repeat protein
351627000099	KWG Leptospira; Region: KWG; pfam07656
351627000100	LemA family; Region: LemA; pfam04011
351627000101	Repair protein; Region: Repair_PSII; pfam04536
351627000102	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627000103	Integrase core domain; Region: rve; pfam00665
351627000104	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627000105	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351627000106	Walker A motif; other site
351627000107	ATP binding site [chemical binding]; other site
351627000108	Walker B motif; other site
351627000109	arginine finger; other site
351627000110	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
351627000111	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09728
351627000112	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
351627000113	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
351627000114	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
351627000115	Transposase domain (DUF772); Region: DUF772; pfam05598
351627000116	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627000117	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627000118	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
351627000119	Archaeal ATPase; Region: Arch_ATPase; pfam01637
351627000120	AAA domain; Region: AAA_14; pfam13173
351627000121	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
351627000122	potential frameshift: common BLAST hit: gi|344997609|ref|YP_004799952.1| CRISPR-associated protein
351627000123	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
351627000124	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627000125	MULE transposase domain; Region: MULE; pfam10551
351627000126	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627000127	Integrase core domain; Region: rve; pfam00665
351627000128	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730
351627000129	Family of unknown function (DUF694); Region: DUF694; pfam05107
351627000130	CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592
351627000131	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
351627000132	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
351627000133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627000134	Walker A motif; other site
351627000135	ATP binding site [chemical binding]; other site
351627000136	Walker B motif; other site
351627000137	arginine finger; other site
351627000138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627000139	MULE transposase domain; Region: MULE; pfam10551
351627000140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627000141	Integrase core domain; Region: rve; pfam00665
351627000142	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
351627000143	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
351627000144	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
351627000145	Zeta toxin; Region: Zeta_toxin; pfam06414
351627000146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
351627000147	Transposase domain (DUF772); Region: DUF772; pfam05598
351627000148	Archaeal ATPase; Region: Arch_ATPase; pfam01637
351627000149	AAA ATPase domain; Region: AAA_16; pfam13191
351627000150	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
351627000151	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
351627000152	Restriction endonuclease; Region: Mrr_cat; pfam04471
351627000153	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
351627000154	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
351627000155	Protein of unknown function (DUF310); Region: DUF310; pfam03750
351627000156	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
351627000157	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
351627000158	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
351627000159	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
351627000160	YcfA-like protein; Region: YcfA; pfam07927
351627000161	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627000162	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
351627000163	putative active site [active]
351627000164	type IV secretion system ATPase VirB4; Provisional; Region: PRK13898
351627000165	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09728
351627000166	CRISPR-associated protein, MJ1666 family; Region: cas_MJ1666; TIGR01897
351627000167	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
351627000168	stage V sporulation protein AD; Validated; Region: PRK08304
351627000169	stage V sporulation protein AD; Provisional; Region: PRK12404
351627000170	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
351627000171	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
351627000172	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
351627000173	YvrJ protein family; Region: YvrJ; pfam12841
351627000174	Domain of unknown function DUF87; Region: DUF87; pfam01935
351627000175	AAA-like domain; Region: AAA_10; pfam12846
351627000176	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
351627000177	Transposase domain (DUF772); Region: DUF772; pfam05598
351627000178	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627000179	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627000180	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
351627000181	Ligand Binding Site [chemical binding]; other site
351627000182	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
351627000183	homotrimer interaction site [polypeptide binding]; other site
351627000184	putative active site [active]
351627000185	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
351627000186	Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104
351627000187	charged pocket; other site
351627000188	hydrophobic patch; other site
351627000189	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
351627000190	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
351627000191	Ligand Binding Site [chemical binding]; other site
351627000192	TIGR00269 family protein; Region: TIGR00269
351627000193	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
351627000194	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627000195	FeS/SAM binding site; other site
351627000196	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
351627000197	Protein of unknown function (DUF1284); Region: DUF1284; pfam06935
351627000198	Biotin operon repressor [Transcription]; Region: BirA; COG1654
351627000199	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
351627000200	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
351627000201	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
351627000202	dihydropteroate synthase; Region: DHPS; TIGR01496
351627000203	substrate binding pocket [chemical binding]; other site
351627000204	dimer interface [polypeptide binding]; other site
351627000205	inhibitor binding site; inhibition site
351627000206	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
351627000207	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
351627000208	catalytic center binding site [active]
351627000209	ATP binding site [chemical binding]; other site
351627000210	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
351627000211	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351627000212	NAD(P) binding site [chemical binding]; other site
351627000213	active site
351627000214	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
351627000215	putative active site [active]
351627000216	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
351627000217	phage shock protein A; Region: phageshock_pspA; TIGR02977
351627000218	stage II sporulation protein E; Region: spore_II_E; TIGR02865
351627000219	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
351627000220	stage II sporulation protein D; Region: spore_II_D; TIGR02870
351627000221	Stage II sporulation protein; Region: SpoIID; pfam08486
351627000222	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
351627000223	NAD synthetase; Provisional; Region: PRK13981
351627000224	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
351627000225	multimer interface [polypeptide binding]; other site
351627000226	active site
351627000227	catalytic triad [active]
351627000228	protein interface 1 [polypeptide binding]; other site
351627000229	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
351627000230	homodimer interface [polypeptide binding]; other site
351627000231	NAD binding pocket [chemical binding]; other site
351627000232	ATP binding pocket [chemical binding]; other site
351627000233	Mg binding site [ion binding]; other site
351627000234	active-site loop [active]
351627000235	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627000236	active site
351627000237	NTP binding site [chemical binding]; other site
351627000238	metal binding triad [ion binding]; metal-binding site
351627000239	antibiotic binding site [chemical binding]; other site
351627000240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627000241	Response regulator receiver domain; Region: Response_reg; pfam00072
351627000242	active site
351627000243	phosphorylation site [posttranslational modification]
351627000244	intermolecular recognition site; other site
351627000245	dimerization interface [polypeptide binding]; other site
351627000246	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627000247	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627000248	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627000249	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
351627000250	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627000251	dimerization interface [polypeptide binding]; other site
351627000252	Histidine kinase; Region: His_kinase; pfam06580
351627000253	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627000254	ATP binding site [chemical binding]; other site
351627000255	Mg2+ binding site [ion binding]; other site
351627000256	G-X-G motif; other site
351627000257	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627000258	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627000259	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627000260	dimer interface [polypeptide binding]; other site
351627000261	conserved gate region; other site
351627000262	putative PBP binding loops; other site
351627000263	ABC-ATPase subunit interface; other site
351627000264	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627000265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627000266	dimer interface [polypeptide binding]; other site
351627000267	conserved gate region; other site
351627000268	putative PBP binding loops; other site
351627000269	ABC-ATPase subunit interface; other site
351627000270	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
351627000271	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
351627000272	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
351627000273	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
351627000274	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627000275	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
351627000276	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
351627000277	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
351627000278	Substrate binding site; other site
351627000279	Mg++ binding site; other site
351627000280	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
351627000281	putative trimer interface [polypeptide binding]; other site
351627000282	putative CoA binding site [chemical binding]; other site
351627000283	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
351627000284	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
351627000285	metal binding site [ion binding]; metal-binding site
351627000286	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
351627000287	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
351627000288	Predicted integral membrane protein [Function unknown]; Region: COG5652
351627000289	Integrase core domain; Region: rve; pfam00665
351627000290	Predicted transcriptional regulators [Transcription]; Region: COG1725
351627000291	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351627000292	DNA-binding site [nucleotide binding]; DNA binding site
351627000293	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
351627000294	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627000295	Walker A/P-loop; other site
351627000296	ATP binding site [chemical binding]; other site
351627000297	Q-loop/lid; other site
351627000298	ABC transporter signature motif; other site
351627000299	Walker B; other site
351627000300	D-loop; other site
351627000301	H-loop/switch region; other site
351627000302	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
351627000303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627000304	Walker A/P-loop; other site
351627000305	ATP binding site [chemical binding]; other site
351627000306	Q-loop/lid; other site
351627000307	ABC transporter signature motif; other site
351627000308	Walker B; other site
351627000309	D-loop; other site
351627000310	H-loop/switch region; other site
351627000311	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
351627000312	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
351627000313	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
351627000314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
351627000315	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
351627000316	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
351627000317	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
351627000318	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
351627000319	DNA binding residues [nucleotide binding]
351627000320	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
351627000321	catalytic nucleophile [active]
351627000322	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
351627000323	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
351627000324	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
351627000325	TrkA-N domain; Region: TrkA_N; pfam02254
351627000326	TrkA-C domain; Region: TrkA_C; pfam02080
351627000327	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
351627000328	TrkA-N domain; Region: TrkA_N; pfam02254
351627000329	Sporulation related domain; Region: SPOR; cl10051
351627000330	Stage II sporulation protein; Region: SpoIID; pfam08486
351627000331	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
351627000332	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
351627000333	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
351627000334	Orthopoxvirus A26L/A30L protein; Region: Pox_A30L_A26L; cl17524
351627000335	TIGR02680 family protein; Region: TIGR02680
351627000336	TIGR02680 family protein; Region: TIGR02680
351627000337	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
351627000338	Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796
351627000339	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
351627000340	active site
351627000341	metal binding site [ion binding]; metal-binding site
351627000342	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
351627000343	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
351627000344	putative active site [active]
351627000345	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627000346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627000347	Walker A/P-loop; other site
351627000348	ATP binding site [chemical binding]; other site
351627000349	Q-loop/lid; other site
351627000350	ABC transporter signature motif; other site
351627000351	Walker B; other site
351627000352	D-loop; other site
351627000353	H-loop/switch region; other site
351627000354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627000355	MULE transposase domain; Region: MULE; pfam10551
351627000356	CAAX protease self-immunity; Region: Abi; pfam02517
351627000357	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
351627000358	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
351627000359	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
351627000360	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627000361	Walker A/P-loop; other site
351627000362	ATP binding site [chemical binding]; other site
351627000363	Q-loop/lid; other site
351627000364	ABC transporter signature motif; other site
351627000365	Walker B; other site
351627000366	D-loop; other site
351627000367	H-loop/switch region; other site
351627000368	CAAX protease self-immunity; Region: Abi; pfam02517
351627000369	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
351627000370	active site
351627000371	catalytic residues [active]
351627000372	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
351627000373	catalytic residues [active]
351627000374	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
351627000375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627000376	S-adenosylmethionine binding site [chemical binding]; other site
351627000377	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351627000378	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
351627000379	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
351627000380	dimer interface [polypeptide binding]; other site
351627000381	putative PBP binding regions; other site
351627000382	ABC-ATPase subunit  interface; other site
351627000383	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
351627000384	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
351627000385	Walker A/P-loop; other site
351627000386	ATP binding site [chemical binding]; other site
351627000387	Q-loop/lid; other site
351627000388	ABC transporter signature motif; other site
351627000389	Walker B; other site
351627000390	D-loop; other site
351627000391	H-loop/switch region; other site
351627000392	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
351627000393	homodimer interaction site [polypeptide binding]; other site
351627000394	cofactor binding site; other site
351627000395	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
351627000396	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
351627000397	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
351627000398	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
351627000399	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
351627000400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627000401	active site
351627000402	phosphorylation site [posttranslational modification]
351627000403	intermolecular recognition site; other site
351627000404	dimerization interface [polypeptide binding]; other site
351627000405	CheB methylesterase; Region: CheB_methylest; pfam01339
351627000406	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
351627000407	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
351627000408	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
351627000409	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
351627000410	active site
351627000411	HIGH motif; other site
351627000412	KMSKS motif; other site
351627000413	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
351627000414	tRNA binding surface [nucleotide binding]; other site
351627000415	anticodon binding site; other site
351627000416	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
351627000417	dimer interface [polypeptide binding]; other site
351627000418	putative tRNA-binding site [nucleotide binding]; other site
351627000419	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
351627000420	active site
351627000421	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
351627000422	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627000423	FeS/SAM binding site; other site
351627000424	Transposase IS200 like; Region: Y1_Tnp; pfam01797
351627000425	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
351627000426	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
351627000427	Probable transposase; Region: OrfB_IS605; pfam01385
351627000428	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
351627000429	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
351627000430	Bifunctional nuclease; Region: DNase-RNase; pfam02577
351627000431	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
351627000432	Heavy-metal-associated domain; Region: HMA; pfam00403
351627000433	metal-binding site [ion binding]
351627000434	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351627000435	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627000436	dimerization interface [polypeptide binding]; other site
351627000437	putative DNA binding site [nucleotide binding]; other site
351627000438	putative Zn2+ binding site [ion binding]; other site
351627000439	This family is most closely related to the GT1 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose...; Region: GT1_AmsK_like; cd04946
351627000440	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627000441	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
351627000442	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351627000443	active site
351627000444	motif I; other site
351627000445	motif II; other site
351627000446	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351627000447	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
351627000448	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
351627000449	AAA domain; Region: AAA_30; pfam13604
351627000450	Family description; Region: UvrD_C_2; pfam13538
351627000451	BioY family; Region: BioY; pfam02632
351627000452	YcfA-like protein; Region: YcfA; cl00752
351627000453	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
351627000454	HicB family; Region: HicB; pfam05534
351627000455	Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335
351627000456	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
351627000457	homodimer interface [polypeptide binding]; other site
351627000458	active site
351627000459	catalytic site [active]
351627000460	maltose binding site 2 [chemical binding]; other site
351627000461	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
351627000462	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
351627000463	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
351627000464	putative active site [active]
351627000465	putative metal binding site [ion binding]; other site
351627000466	Domain of unknown function (DUF303); Region: DUF303; pfam03629
351627000467	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
351627000468	Domain of unknown function (DUF303); Region: DUF303; pfam03629
351627000469	S-layer homology domain; Region: SLH; pfam00395
351627000470	Bacterial Ig-like domain; Region: Big_5; pfam13205
351627000471	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
351627000472	active site
351627000473	putative GTP cyclohydrolase; Provisional; Region: PRK13674
351627000474	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
351627000475	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
351627000476	active site
351627000477	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
351627000478	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
351627000479	Glycoprotease family; Region: Peptidase_M22; pfam00814
351627000480	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
351627000481	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351627000482	Coenzyme A binding pocket [chemical binding]; other site
351627000483	HEPN domain; Region: HEPN; pfam05168
351627000484	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627000485	active site
351627000486	NTP binding site [chemical binding]; other site
351627000487	metal binding triad [ion binding]; metal-binding site
351627000488	antibiotic binding site [chemical binding]; other site
351627000489	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351627000490	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351627000491	metal binding site [ion binding]; metal-binding site
351627000492	active site
351627000493	I-site; other site
351627000494	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351627000495	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
351627000496	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
351627000497	Walker A motif; other site
351627000498	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
351627000499	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
351627000500	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
351627000501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627000502	DNA binding residues [nucleotide binding]
351627000503	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351627000504	metal-binding site [ion binding]
351627000505	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351627000506	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
351627000507	metal-binding site [ion binding]
351627000508	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351627000509	Soluble P-type ATPase [General function prediction only]; Region: COG4087
351627000510	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351627000511	metal-binding site [ion binding]
351627000512	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351627000513	metal-binding site [ion binding]
351627000514	Protein of unknown function (DUF1646); Region: DUF1646; pfam07854
351627000515	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627000516	active site
351627000517	NTP binding site [chemical binding]; other site
351627000518	metal binding triad [ion binding]; metal-binding site
351627000519	antibiotic binding site [chemical binding]; other site
351627000520	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
351627000521	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627000522	FeS/SAM binding site; other site
351627000523	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
351627000524	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
351627000525	putative active site [active]
351627000526	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
351627000527	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
351627000528	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
351627000529	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
351627000530	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
351627000531	Walker A/P-loop; other site
351627000532	ATP binding site [chemical binding]; other site
351627000533	Q-loop/lid; other site
351627000534	ABC transporter signature motif; other site
351627000535	Walker B; other site
351627000536	D-loop; other site
351627000537	H-loop/switch region; other site
351627000538	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
351627000539	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
351627000540	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
351627000541	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
351627000542	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
351627000543	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
351627000544	Walker A/P-loop; other site
351627000545	ATP binding site [chemical binding]; other site
351627000546	Q-loop/lid; other site
351627000547	ABC transporter signature motif; other site
351627000548	Walker B; other site
351627000549	D-loop; other site
351627000550	H-loop/switch region; other site
351627000551	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
351627000552	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
351627000553	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351627000554	TM-ABC transporter signature motif; other site
351627000555	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
351627000556	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
351627000557	ligand binding site [chemical binding]; other site
351627000558	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627000559	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
351627000560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
351627000561	FOG: CBS domain [General function prediction only]; Region: COG0517
351627000562	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
351627000563	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
351627000564	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
351627000565	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
351627000566	thiS-thiF/thiG interaction site; other site
351627000567	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
351627000568	ThiS interaction site; other site
351627000569	putative active site [active]
351627000570	tetramer interface [polypeptide binding]; other site
351627000571	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
351627000572	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627000573	FeS/SAM binding site; other site
351627000574	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
351627000575	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
351627000576	E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487
351627000577	putative ATP binding site [chemical binding]; other site
351627000578	putative substrate interface [chemical binding]; other site
351627000579	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
351627000580	thiamine phosphate binding site [chemical binding]; other site
351627000581	active site
351627000582	pyrophosphate binding site [ion binding]; other site
351627000583	ThiC family; Region: ThiC; pfam01964
351627000584	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
351627000585	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
351627000586	dimer interface [polypeptide binding]; other site
351627000587	substrate binding site [chemical binding]; other site
351627000588	ATP binding site [chemical binding]; other site
351627000589	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
351627000590	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
351627000591	Domain of unknown function (DUF377); Region: DUF377; pfam04041
351627000592	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
351627000593	active site
351627000594	Domain of unknown function (DUF377); Region: DUF377; pfam04041
351627000595	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
351627000596	active site
351627000597	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627000598	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351627000599	DNA binding site [nucleotide binding]
351627000600	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
351627000601	putative dimerization interface [polypeptide binding]; other site
351627000602	putative ligand binding site [chemical binding]; other site
351627000603	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
351627000604	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
351627000605	substrate binding site [chemical binding]; other site
351627000606	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
351627000607	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627000608	dimer interface [polypeptide binding]; other site
351627000609	conserved gate region; other site
351627000610	putative PBP binding loops; other site
351627000611	ABC-ATPase subunit interface; other site
351627000612	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
351627000613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627000614	dimer interface [polypeptide binding]; other site
351627000615	conserved gate region; other site
351627000616	putative PBP binding loops; other site
351627000617	ABC-ATPase subunit interface; other site
351627000618	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
351627000619	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351627000620	Walker A/P-loop; other site
351627000621	ATP binding site [chemical binding]; other site
351627000622	Q-loop/lid; other site
351627000623	ABC transporter signature motif; other site
351627000624	Walker B; other site
351627000625	D-loop; other site
351627000626	H-loop/switch region; other site
351627000627	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
351627000628	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
351627000629	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351627000630	Walker A/P-loop; other site
351627000631	ATP binding site [chemical binding]; other site
351627000632	Q-loop/lid; other site
351627000633	ABC transporter signature motif; other site
351627000634	Walker B; other site
351627000635	D-loop; other site
351627000636	H-loop/switch region; other site
351627000637	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
351627000638	conserved hypothetical integral membrane protein; Region: TIGR03766
351627000639	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
351627000640	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
351627000641	Ligand binding site; other site
351627000642	Putative Catalytic site; other site
351627000643	DXD motif; other site
351627000644	Predicted membrane protein [Function unknown]; Region: COG2246
351627000645	GtrA-like protein; Region: GtrA; pfam04138
351627000646	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
351627000647	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627000648	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
351627000649	FeS/SAM binding site; other site
351627000650	Preprotein translocase subunit; Region: YajC; pfam02699
351627000651	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
351627000652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627000653	S-adenosylmethionine binding site [chemical binding]; other site
351627000654	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
351627000655	active site
351627000656	substrate-binding site [chemical binding]; other site
351627000657	metal-binding site [ion binding]
351627000658	GTP binding site [chemical binding]; other site
351627000659	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
351627000660	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
351627000661	Substrate binding site; other site
351627000662	Cupin domain; Region: Cupin_2; cl17218
351627000663	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; pfam09560
351627000664	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
351627000665	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
351627000666	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
351627000667	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
351627000668	Uso1 / p115 like vesicle tethering protein, C terminal region; Region: Uso1_p115_C; pfam04871
351627000669	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
351627000670	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
351627000671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627000672	MULE transposase domain; Region: MULE; pfam10551
351627000673	potential frameshift: common BLAST hit: gi|222530528|ref|YP_002574410.1| transglutaminase domain-containing protein
351627000674	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
351627000675	protein-splicing catalytic site; other site
351627000676	thioester formation/cholesterol transfer; other site
351627000677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
351627000678	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000679	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000680	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627000681	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000682	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627000683	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000684	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000685	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627000686	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000687	Hemerythrin; Region: Hemerythrin; cd12107
351627000688	Fe binding site [ion binding]; other site
351627000689	potential frameshift: common BLAST hit: gi|222530528|ref|YP_002574410.1| transglutaminase domain-containing protein
351627000690	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
351627000691	protein-splicing catalytic site; other site
351627000692	thioester formation/cholesterol transfer; other site
351627000693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627000694	MULE transposase domain; Region: MULE; pfam10551
351627000695	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627000696	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000697	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627000698	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000699	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000700	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627000701	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627000702	MoxR-like ATPases [General function prediction only]; Region: COG0714
351627000703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627000704	Walker A motif; other site
351627000705	ATP binding site [chemical binding]; other site
351627000706	Walker B motif; other site
351627000707	arginine finger; other site
351627000708	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
351627000709	dimer interface [polypeptide binding]; other site
351627000710	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351627000711	substrate binding site [chemical binding]; other site
351627000712	metal binding site [ion binding]; metal-binding site
351627000713	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
351627000714	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
351627000715	dimerization interface [polypeptide binding]; other site
351627000716	putative active cleft [active]
351627000717	Domain of unknown function (DUF377); Region: DUF377; pfam04041
351627000718	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
351627000719	active site
351627000720	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627000721	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627000722	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627000723	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627000724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627000725	dimer interface [polypeptide binding]; other site
351627000726	conserved gate region; other site
351627000727	putative PBP binding loops; other site
351627000728	ABC-ATPase subunit interface; other site
351627000729	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627000730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627000731	dimer interface [polypeptide binding]; other site
351627000732	conserved gate region; other site
351627000733	ABC-ATPase subunit interface; other site
351627000734	HAMP domain; Region: HAMP; pfam00672
351627000735	Histidine kinase; Region: His_kinase; pfam06580
351627000736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627000737	ATP binding site [chemical binding]; other site
351627000738	Mg2+ binding site [ion binding]; other site
351627000739	G-X-G motif; other site
351627000740	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
351627000741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627000742	active site
351627000743	phosphorylation site [posttranslational modification]
351627000744	intermolecular recognition site; other site
351627000745	dimerization interface [polypeptide binding]; other site
351627000746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627000747	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
351627000748	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
351627000749	THF binding site; other site
351627000750	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
351627000751	substrate binding site [chemical binding]; other site
351627000752	THF binding site; other site
351627000753	zinc-binding site [ion binding]; other site
351627000754	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
351627000755	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
351627000756	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
351627000757	AAA domain; Region: AAA_26; pfam13500
351627000758	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351627000759	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
351627000760	inhibitor-cofactor binding pocket; inhibition site
351627000761	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627000762	catalytic residue [active]
351627000763	biotin synthase; Region: bioB; TIGR00433
351627000764	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627000765	FeS/SAM binding site; other site
351627000766	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
351627000767	CCA-adding enzyme; Region: cca_archaeal; TIGR03671
351627000768	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
351627000769	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
351627000770	CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905
351627000771	CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895
351627000772	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
351627000773	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
351627000774	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
351627000775	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
351627000776	Transposase domain (DUF772); Region: DUF772; pfam05598
351627000777	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627000778	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627000779	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
351627000780	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
351627000781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627000782	Walker A motif; other site
351627000783	ATP binding site [chemical binding]; other site
351627000784	Walker B motif; other site
351627000785	arginine finger; other site
351627000786	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627000787	MULE transposase domain; Region: MULE; pfam10551
351627000788	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627000789	Homeodomain-like domain; Region: HTH_23; pfam13384
351627000790	Integrase core domain; Region: rve; pfam00665
351627000791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351627000792	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627000793	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627000794	MULE transposase domain; Region: MULE; pfam10551
351627000795	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627000796	transposase; Provisional; Region: PRK06526
351627000797	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627000798	Walker A motif; other site
351627000799	ATP binding site [chemical binding]; other site
351627000800	Transposase, Mutator family; Region: Transposase_mut; pfam00872
351627000801	MULE transposase domain; Region: MULE; pfam10551
351627000802	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
351627000803	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
351627000804	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
351627000805	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
351627000806	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351627000807	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
351627000808	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
351627000809	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351627000810	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
351627000811	pur operon repressor; Provisional; Region: PRK09213
351627000812	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
351627000813	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627000814	active site
351627000815	regulatory protein SpoVG; Reviewed; Region: PRK13259
351627000816	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
351627000817	NodB motif; other site
351627000818	putative active site [active]
351627000819	putative catalytic site [active]
351627000820	Zn binding site [ion binding]; other site
351627000821	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
351627000822	nucleoside/Zn binding site; other site
351627000823	dimer interface [polypeptide binding]; other site
351627000824	catalytic motif [active]
351627000825	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
351627000826	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
351627000827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
351627000828	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
351627000829	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627000830	putative DNA binding site [nucleotide binding]; other site
351627000831	putative Zn2+ binding site [ion binding]; other site
351627000832	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
351627000833	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
351627000834	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
351627000835	N- and C-terminal domain interface [polypeptide binding]; other site
351627000836	putative active site [active]
351627000837	MgATP binding site [chemical binding]; other site
351627000838	catalytic site [active]
351627000839	metal binding site [ion binding]; metal-binding site
351627000840	putative xylulose binding site [chemical binding]; other site
351627000841	putative homodimer interface [polypeptide binding]; other site
351627000842	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
351627000843	intersubunit interface [polypeptide binding]; other site
351627000844	active site
351627000845	zinc binding site [ion binding]; other site
351627000846	Na+ binding site [ion binding]; other site
351627000847	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
351627000848	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
351627000849	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
351627000850	glyoxylate reductase; Reviewed; Region: PRK13243
351627000851	dimerization interface [polypeptide binding]; other site
351627000852	ligand binding site [chemical binding]; other site
351627000853	NADP binding site [chemical binding]; other site
351627000854	catalytic site [active]
351627000855	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
351627000856	Transcriptional regulator [Transcription]; Region: IclR; COG1414
351627000857	Bacterial transcriptional regulator; Region: IclR; pfam01614
351627000858	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627000859	MULE transposase domain; Region: MULE; pfam10551
351627000860	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
351627000861	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
351627000862	active site
351627000863	intersubunit interface [polypeptide binding]; other site
351627000864	catalytic residue [active]
351627000865	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
351627000866	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
351627000867	substrate binding site [chemical binding]; other site
351627000868	ATP binding site [chemical binding]; other site
351627000869	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
351627000870	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
351627000871	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
351627000872	NADP binding site [chemical binding]; other site
351627000873	homodimer interface [polypeptide binding]; other site
351627000874	active site
351627000875	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627000876	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627000877	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
351627000878	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
351627000879	active site
351627000880	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
351627000881	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
351627000882	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
351627000883	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
351627000884	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
351627000885	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
351627000886	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
351627000887	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
351627000888	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
351627000889	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
351627000890	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
351627000891	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
351627000892	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
351627000893	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
351627000894	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627000895	Walker A/P-loop; other site
351627000896	ATP binding site [chemical binding]; other site
351627000897	Q-loop/lid; other site
351627000898	ABC transporter signature motif; other site
351627000899	Walker B; other site
351627000900	D-loop; other site
351627000901	H-loop/switch region; other site
351627000902	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
351627000903	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
351627000904	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
351627000905	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
351627000906	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
351627000907	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351627000908	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
351627000909	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
351627000910	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
351627000911	Integrase core domain; Region: rve; pfam00665
351627000912	Transglycosylase; Region: Transgly; pfam00912
351627000913	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
351627000914	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
351627000915	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627000916	Walker A motif; other site
351627000917	ATP binding site [chemical binding]; other site
351627000918	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627000919	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627000920	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627000921	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351627000922	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351627000923	metal binding site [ion binding]; metal-binding site
351627000924	active site
351627000925	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
351627000926	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627000927	Zn2+ binding site [ion binding]; other site
351627000928	Mg2+ binding site [ion binding]; other site
351627000929	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
351627000930	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
351627000931	active site
351627000932	metal binding site [ion binding]; metal-binding site
351627000933	homotetramer interface [polypeptide binding]; other site
351627000934	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
351627000935	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
351627000936	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
351627000937	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
351627000938	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
351627000939	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
351627000940	amino acid transporter; Region: 2A0306; TIGR00909
351627000941	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
351627000942	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
351627000943	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
351627000944	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
351627000945	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
351627000946	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
351627000947	active site
351627000948	Integrase core domain; Region: rve; pfam00665
351627000949	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627000950	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351627000951	DNA binding site [nucleotide binding]
351627000952	domain linker motif; other site
351627000953	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
351627000954	ligand binding site [chemical binding]; other site
351627000955	dimerization interface [polypeptide binding]; other site
351627000956	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
351627000957	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
351627000958	Pleckstrin homology-like domain; Region: PH-like; cl17171
351627000959	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
351627000960	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
351627000961	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
351627000962	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
351627000963	Walker A/P-loop; other site
351627000964	ATP binding site [chemical binding]; other site
351627000965	Q-loop/lid; other site
351627000966	ABC transporter signature motif; other site
351627000967	Walker B; other site
351627000968	D-loop; other site
351627000969	H-loop/switch region; other site
351627000970	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
351627000971	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351627000972	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
351627000973	TM-ABC transporter signature motif; other site
351627000974	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351627000975	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
351627000976	TM-ABC transporter signature motif; other site
351627000977	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
351627000978	L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239
351627000979	putative NAD(P) binding site [chemical binding]; other site
351627000980	catalytic Zn binding site [ion binding]; other site
351627000981	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
351627000982	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
351627000983	DNA interaction; other site
351627000984	Metal-binding active site; metal-binding site
351627000985	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
351627000986	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
351627000987	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
351627000988	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627000989	dimerization interface [polypeptide binding]; other site
351627000990	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351627000991	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627000992	dimer interface [polypeptide binding]; other site
351627000993	putative CheW interface [polypeptide binding]; other site
351627000994	Rrf2 family protein; Region: rrf2_super; TIGR00738
351627000995	Transcriptional regulator; Region: Rrf2; pfam02082
351627000996	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
351627000997	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351627000998	ACS interaction site; other site
351627000999	CODH interaction site; other site
351627001000	metal cluster binding site [ion binding]; other site
351627001001	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
351627001002	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
351627001003	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351627001004	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
351627001005	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627001006	dimerization interface [polypeptide binding]; other site
351627001007	putative Zn2+ binding site [ion binding]; other site
351627001008	putative DNA binding site [nucleotide binding]; other site
351627001009	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627001010	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
351627001011	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627001012	Walker A/P-loop; other site
351627001013	ATP binding site [chemical binding]; other site
351627001014	Q-loop/lid; other site
351627001015	ABC transporter signature motif; other site
351627001016	Walker B; other site
351627001017	D-loop; other site
351627001018	H-loop/switch region; other site
351627001019	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627001020	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627001021	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
351627001022	Walker A/P-loop; other site
351627001023	ATP binding site [chemical binding]; other site
351627001024	Q-loop/lid; other site
351627001025	ABC transporter signature motif; other site
351627001026	Walker B; other site
351627001027	D-loop; other site
351627001028	H-loop/switch region; other site
351627001029	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627001030	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627001031	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
351627001032	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
351627001033	dimer interface [polypeptide binding]; other site
351627001034	active site
351627001035	metal binding site [ion binding]; metal-binding site
351627001036	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
351627001037	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
351627001038	Ca binding site [ion binding]; other site
351627001039	active site
351627001040	catalytic site [active]
351627001041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627001042	S-adenosylmethionine binding site [chemical binding]; other site
351627001043	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
351627001044	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
351627001045	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
351627001046	Probable transposase; Region: OrfB_IS605; pfam01385
351627001047	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
351627001048	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
351627001049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627001050	S-adenosylmethionine binding site [chemical binding]; other site
351627001051	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351627001052	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627001053	dimer interface [polypeptide binding]; other site
351627001054	putative CheW interface [polypeptide binding]; other site
351627001055	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
351627001056	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
351627001057	hinge; other site
351627001058	active site
351627001059	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351627001060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627001061	active site
351627001062	phosphorylation site [posttranslational modification]
351627001063	intermolecular recognition site; other site
351627001064	dimerization interface [polypeptide binding]; other site
351627001065	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351627001066	DNA binding site [nucleotide binding]
351627001067	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351627001068	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
351627001069	dimerization interface [polypeptide binding]; other site
351627001070	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351627001071	dimer interface [polypeptide binding]; other site
351627001072	phosphorylation site [posttranslational modification]
351627001073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627001074	Mg2+ binding site [ion binding]; other site
351627001075	G-X-G motif; other site
351627001076	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
351627001077	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
351627001078	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
351627001079	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
351627001080	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
351627001081	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
351627001082	B12 binding site [chemical binding]; other site
351627001083	cobalt ligand [ion binding]; other site
351627001084	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
351627001085	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
351627001086	intersubunit interface [polypeptide binding]; other site
351627001087	active site
351627001088	Zn2+ binding site [ion binding]; other site
351627001089	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
351627001090	homodimer interface [polypeptide binding]; other site
351627001091	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
351627001092	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
351627001093	active site
351627001094	homodimer interface [polypeptide binding]; other site
351627001095	catalytic site [active]
351627001096	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627001097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627001098	putative PBP binding loops; other site
351627001099	ABC-ATPase subunit interface; other site
351627001100	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627001101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627001102	dimer interface [polypeptide binding]; other site
351627001103	conserved gate region; other site
351627001104	putative PBP binding loops; other site
351627001105	ABC-ATPase subunit interface; other site
351627001106	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
351627001107	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
351627001108	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627001109	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351627001110	DNA binding site [nucleotide binding]
351627001111	domain linker motif; other site
351627001112	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
351627001113	putative dimerization interface [polypeptide binding]; other site
351627001114	putative ligand binding site [chemical binding]; other site
351627001115	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
351627001116	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627001117	Probable transposase; Region: OrfB_IS605; pfam01385
351627001118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627001119	MULE transposase domain; Region: MULE; pfam10551
351627001120	Probable transposase; Region: OrfB_IS605; pfam01385
351627001121	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
351627001122	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
351627001123	Glycosyl hydrolase family 43; Region: GH43_5; cd08984
351627001124	active site
351627001125	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
351627001126	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351627001127	motif II; other site
351627001128	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
351627001129	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
351627001130	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
351627001131	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
351627001132	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627001133	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627001134	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627001135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627001136	putative PBP binding loops; other site
351627001137	dimer interface [polypeptide binding]; other site
351627001138	ABC-ATPase subunit interface; other site
351627001139	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627001140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627001141	dimer interface [polypeptide binding]; other site
351627001142	conserved gate region; other site
351627001143	putative PBP binding loops; other site
351627001144	ABC-ATPase subunit interface; other site
351627001145	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627001146	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351627001147	DNA binding site [nucleotide binding]
351627001148	domain linker motif; other site
351627001149	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
351627001150	ligand binding site [chemical binding]; other site
351627001151	dimerization interface [polypeptide binding]; other site
351627001152	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
351627001153	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
351627001154	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
351627001155	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
351627001156	Rubrerythrin [Energy production and conversion]; Region: COG1592
351627001157	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
351627001158	binuclear metal center [ion binding]; other site
351627001159	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
351627001160	iron binding site [ion binding]; other site
351627001161	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351627001162	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
351627001163	active site
351627001164	catalytic tetrad [active]
351627001165	Cell division protein ZapA; Region: ZapA; pfam05164
351627001166	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
351627001167	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
351627001168	Peptidase family U32; Region: Peptidase_U32; pfam01136
351627001169	Collagenase; Region: DUF3656; pfam12392
351627001170	Peptidase family U32; Region: Peptidase_U32; cl03113
351627001171	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
351627001172	Domain of unknown function DUF20; Region: UPF0118; pfam01594
351627001173	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
351627001174	Uncharacterized conserved protein [Function unknown]; Region: COG0398
351627001175	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
351627001176	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
351627001177	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
351627001178	active site
351627001179	metal binding site [ion binding]; metal-binding site
351627001180	dipeptidase PepV; Reviewed; Region: PRK07318
351627001181	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
351627001182	active site
351627001183	metal binding site [ion binding]; metal-binding site
351627001184	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
351627001185	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
351627001186	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627001187	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627001188	DNA binding residues [nucleotide binding]
351627001189	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
351627001190	anti sigma factor interaction site; other site
351627001191	regulatory phosphorylation site [posttranslational modification]; other site
351627001192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
351627001193	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
351627001194	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627001195	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
351627001196	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627001197	DNA binding residues [nucleotide binding]
351627001198	Hemerythrin; Region: Hemerythrin; cd12107
351627001199	Fe binding site [ion binding]; other site
351627001200	Integrase core domain; Region: rve; pfam00665
351627001201	TRAM domain; Region: TRAM; cl01282
351627001202	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
351627001203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627001204	S-adenosylmethionine binding site [chemical binding]; other site
351627001205	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
351627001206	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627001207	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627001208	DNA binding residues [nucleotide binding]
351627001209	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
351627001210	Transposase domain (DUF772); Region: DUF772; pfam05598
351627001211	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627001212	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627001213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627001214	Homeodomain-like domain; Region: HTH_23; pfam13384
351627001215	Integrase core domain; Region: rve; pfam00665
351627001216	Integrase core domain; Region: rve_3; cl15866
351627001217	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
351627001218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627001219	Walker A motif; other site
351627001220	ATP binding site [chemical binding]; other site
351627001221	Walker B motif; other site
351627001222	arginine finger; other site
351627001223	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
351627001224	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
351627001225	catalytic residues [active]
351627001226	Recombinase; Region: Recombinase; pfam07508
351627001227	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
351627001228	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627001229	dimerization interface [polypeptide binding]; other site
351627001230	putative DNA binding site [nucleotide binding]; other site
351627001231	putative Zn2+ binding site [ion binding]; other site
351627001232	Heavy-metal-associated domain; Region: HMA; pfam00403
351627001233	metal-binding site [ion binding]
351627001234	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
351627001235	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
351627001236	metal-binding site [ion binding]
351627001237	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351627001238	Soluble P-type ATPase [General function prediction only]; Region: COG4087
351627001239	lipoprotein signal peptidase; Provisional; Region: PRK14786
351627001240	lipoprotein signal peptidase; Provisional; Region: PRK14787
351627001241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
351627001242	Probable transposase; Region: OrfB_IS605; pfam01385
351627001243	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627001244	MULE transposase domain; Region: MULE; pfam10551
351627001245	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627001246	Peptidase family M48; Region: Peptidase_M48; cl12018
351627001247	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
351627001248	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
351627001249	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
351627001250	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
351627001251	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
351627001252	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
351627001253	CRISPR-associated protein, TIGR03984 family; Region: TIGR03984
351627001254	CRISPR-associated protein; Region: TIGR03986
351627001255	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
351627001256	Transglycosylase; Region: Transgly; pfam00912
351627001257	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
351627001258	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
351627001259	biotin synthase; Provisional; Region: PRK07094
351627001260	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627001261	FeS/SAM binding site; other site
351627001262	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
351627001263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627001264	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351627001265	putative substrate translocation pore; other site
351627001266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627001267	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
351627001268	putative active site [active]
351627001269	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
351627001270	active site
351627001271	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351627001272	Helix-turn-helix domain; Region: HTH_18; pfam12833
351627001273	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627001274	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
351627001275	Predicted permeases [General function prediction only]; Region: COG0701
351627001276	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627001277	dimerization interface [polypeptide binding]; other site
351627001278	putative DNA binding site [nucleotide binding]; other site
351627001279	putative Zn2+ binding site [ion binding]; other site
351627001280	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
351627001281	YcfA-like protein; Region: YcfA; pfam07927
351627001282	Response regulator receiver domain; Region: Response_reg; pfam00072
351627001283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627001284	phosphorylation site [posttranslational modification]
351627001285	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351627001286	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351627001287	dimerization interface [polypeptide binding]; other site
351627001288	DNA binding residues [nucleotide binding]
351627001289	PIN domain; Region: PIN; pfam01850
351627001290	putative active site [active]
351627001291	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
351627001292	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
351627001293	Walker A/P-loop; other site
351627001294	ATP binding site [chemical binding]; other site
351627001295	Q-loop/lid; other site
351627001296	ABC transporter signature motif; other site
351627001297	Walker B; other site
351627001298	D-loop; other site
351627001299	H-loop/switch region; other site
351627001300	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351627001301	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
351627001302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627001303	ATP binding site [chemical binding]; other site
351627001304	Mg2+ binding site [ion binding]; other site
351627001305	G-X-G motif; other site
351627001306	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351627001307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627001308	active site
351627001309	phosphorylation site [posttranslational modification]
351627001310	intermolecular recognition site; other site
351627001311	dimerization interface [polypeptide binding]; other site
351627001312	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351627001313	DNA binding site [nucleotide binding]
351627001314	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351627001315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627001316	active site
351627001317	phosphorylation site [posttranslational modification]
351627001318	intermolecular recognition site; other site
351627001319	dimerization interface [polypeptide binding]; other site
351627001320	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
351627001321	DNA binding residues [nucleotide binding]
351627001322	dimerization interface [polypeptide binding]; other site
351627001323	Histidine kinase; Region: HisKA_3; pfam07730
351627001324	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
351627001325	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
351627001326	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
351627001327	ABC-2 type transporter; Region: ABC2_membrane; cl17235
351627001328	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
351627001329	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
351627001330	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627001331	Walker A/P-loop; other site
351627001332	ATP binding site [chemical binding]; other site
351627001333	Q-loop/lid; other site
351627001334	ABC transporter signature motif; other site
351627001335	Walker B; other site
351627001336	D-loop; other site
351627001337	H-loop/switch region; other site
351627001338	Protein of unknown function DUF86; Region: DUF86; cl01031
351627001339	Protein of unknown function (DUF554); Region: DUF554; pfam04474
351627001340	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
351627001341	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627001342	putative DNA binding site [nucleotide binding]; other site
351627001343	putative Zn2+ binding site [ion binding]; other site
351627001344	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627001345	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627001346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627001347	Walker A/P-loop; other site
351627001348	ATP binding site [chemical binding]; other site
351627001349	Q-loop/lid; other site
351627001350	ABC transporter signature motif; other site
351627001351	Walker B; other site
351627001352	D-loop; other site
351627001353	H-loop/switch region; other site
351627001354	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627001355	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627001356	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
351627001357	Walker A/P-loop; other site
351627001358	ATP binding site [chemical binding]; other site
351627001359	Q-loop/lid; other site
351627001360	ABC transporter signature motif; other site
351627001361	Walker B; other site
351627001362	D-loop; other site
351627001363	H-loop/switch region; other site
351627001364	circular bacteriocin, circularin A/uberolysin family; Region: circ_ocin_uber; TIGR03651
351627001365	Integral membrane protein DUF95; Region: DUF95; pfam01944
351627001366	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
351627001367	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627001368	Walker A/P-loop; other site
351627001369	ATP binding site [chemical binding]; other site
351627001370	Q-loop/lid; other site
351627001371	ABC transporter signature motif; other site
351627001372	Walker B; other site
351627001373	D-loop; other site
351627001374	H-loop/switch region; other site
351627001375	Yip1 domain; Region: Yip1; pfam04893
351627001376	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
351627001377	carboxyltransferase (CT) interaction site; other site
351627001378	biotinylation site [posttranslational modification]; other site
351627001379	HlyD family secretion protein; Region: HlyD_3; pfam13437
351627001380	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
351627001381	carboxyltransferase (CT) interaction site; other site
351627001382	biotinylation site [posttranslational modification]; other site
351627001383	HlyD family secretion protein; Region: HlyD_3; pfam13437
351627001384	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
351627001385	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
351627001386	FtsX-like permease family; Region: FtsX; pfam02687
351627001387	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
351627001388	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
351627001389	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
351627001390	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
351627001391	Walker A/P-loop; other site
351627001392	ATP binding site [chemical binding]; other site
351627001393	Q-loop/lid; other site
351627001394	ABC transporter signature motif; other site
351627001395	Walker B; other site
351627001396	D-loop; other site
351627001397	H-loop/switch region; other site
351627001398	Protein of unknown function (DUF970); Region: DUF970; cl17525
351627001399	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
351627001400	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351627001401	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
351627001402	Iron permease FTR1 family; Region: FTR1; cl00475
351627001403	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
351627001404	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
351627001405	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
351627001406	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
351627001407	Ligand Binding Site [chemical binding]; other site
351627001408	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627001409	MULE transposase domain; Region: MULE; pfam10551
351627001410	Cupin domain; Region: Cupin_2; pfam07883
351627001411	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
351627001412	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
351627001413	putative active site [active]
351627001414	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
351627001415	4Fe-4S binding domain; Region: Fer4; pfam00037
351627001416	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
351627001417	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
351627001418	active site
351627001419	FMN binding site [chemical binding]; other site
351627001420	substrate binding site [chemical binding]; other site
351627001421	3Fe-4S cluster binding site [ion binding]; other site
351627001422	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
351627001423	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
351627001424	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
351627001425	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351627001426	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351627001427	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
351627001428	putative subunit interface; other site
351627001429	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627001430	Zn2+ binding site [ion binding]; other site
351627001431	Mg2+ binding site [ion binding]; other site
351627001432	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
351627001433	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627001434	dimerization interface [polypeptide binding]; other site
351627001435	putative Zn2+ binding site [ion binding]; other site
351627001436	putative DNA binding site [nucleotide binding]; other site
351627001437	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627001438	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627001439	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627001440	Walker A/P-loop; other site
351627001441	ATP binding site [chemical binding]; other site
351627001442	Q-loop/lid; other site
351627001443	ABC transporter signature motif; other site
351627001444	Walker B; other site
351627001445	D-loop; other site
351627001446	H-loop/switch region; other site
351627001447	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627001448	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627001449	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
351627001450	Walker A/P-loop; other site
351627001451	ATP binding site [chemical binding]; other site
351627001452	Q-loop/lid; other site
351627001453	ABC transporter signature motif; other site
351627001454	Walker B; other site
351627001455	D-loop; other site
351627001456	H-loop/switch region; other site
351627001457	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627001458	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627001459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627001460	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627001461	MULE transposase domain; Region: MULE; pfam10551
351627001462	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
351627001463	putative active site [active]
351627001464	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627001465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
351627001466	Transposase; Region: DDE_Tnp_ISL3; pfam01610
351627001467	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
351627001468	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627001469	FeS/SAM binding site; other site
351627001470	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
351627001471	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
351627001472	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
351627001473	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627001474	FeS/SAM binding site; other site
351627001475	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
351627001476	putative active site [active]
351627001477	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
351627001478	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627001479	Walker A/P-loop; other site
351627001480	ATP binding site [chemical binding]; other site
351627001481	Q-loop/lid; other site
351627001482	ABC transporter signature motif; other site
351627001483	Walker B; other site
351627001484	D-loop; other site
351627001485	H-loop/switch region; other site
351627001486	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
351627001487	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627001488	MULE transposase domain; Region: MULE; pfam10551
351627001489	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
351627001490	sporulation sigma factor SigK; Reviewed; Region: PRK05803
351627001491	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627001492	Cupin domain; Region: Cupin_2; pfam07883
351627001493	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
351627001494	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
351627001495	putative active site [active]
351627001496	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
351627001497	4Fe-4S binding domain; Region: Fer4; pfam00037
351627001498	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
351627001499	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
351627001500	active site
351627001501	FMN binding site [chemical binding]; other site
351627001502	substrate binding site [chemical binding]; other site
351627001503	3Fe-4S cluster binding site [ion binding]; other site
351627001504	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
351627001505	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
351627001506	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
351627001507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351627001508	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351627001509	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
351627001510	putative subunit interface; other site
351627001511	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627001512	Zn2+ binding site [ion binding]; other site
351627001513	Mg2+ binding site [ion binding]; other site
351627001514	L-lactate permease; Region: Lactate_perm; cl00701
351627001515	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
351627001516	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
351627001517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627001518	intermolecular recognition site; other site
351627001519	active site
351627001520	dimerization interface [polypeptide binding]; other site
351627001521	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
351627001522	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
351627001523	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
351627001524	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
351627001525	TraX protein; Region: TraX; pfam05857
351627001526	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627001527	active site
351627001528	NTP binding site [chemical binding]; other site
351627001529	metal binding triad [ion binding]; metal-binding site
351627001530	antibiotic binding site [chemical binding]; other site
351627001531	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
351627001532	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
351627001533	FMN binding site [chemical binding]; other site
351627001534	active site
351627001535	catalytic residues [active]
351627001536	substrate binding site [chemical binding]; other site
351627001537	S-layer homology domain; Region: SLH; pfam00395
351627001538	S-layer homology domain; Region: SLH; pfam00395
351627001539	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
351627001540	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
351627001541	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
351627001542	protein binding site [polypeptide binding]; other site
351627001543	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
351627001544	Catalytic dyad [active]
351627001545	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
351627001546	rod shape-determining protein Mbl; Provisional; Region: PRK13928
351627001547	MreB and similar proteins; Region: MreB_like; cd10225
351627001548	nucleotide binding site [chemical binding]; other site
351627001549	Mg binding site [ion binding]; other site
351627001550	putative protofilament interaction site [polypeptide binding]; other site
351627001551	RodZ interaction site [polypeptide binding]; other site
351627001552	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
351627001553	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
351627001554	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
351627001555	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
351627001556	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
351627001557	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
351627001558	Rod binding protein; Region: Rod-binding; pfam10135
351627001559	Integrase core domain; Region: rve; pfam00665
351627001560	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
351627001561	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
351627001562	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
351627001563	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
351627001564	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
351627001565	Predicted permeases [General function prediction only]; Region: COG0679
351627001566	MoxR-like ATPases [General function prediction only]; Region: COG0714
351627001567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627001568	Walker A motif; other site
351627001569	ATP binding site [chemical binding]; other site
351627001570	Walker B motif; other site
351627001571	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
351627001572	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
351627001573	active site
351627001574	substrate binding site [chemical binding]; other site
351627001575	metal binding site [ion binding]; metal-binding site
351627001576	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
351627001577	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
351627001578	glutaminase active site [active]
351627001579	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
351627001580	dimer interface [polypeptide binding]; other site
351627001581	active site
351627001582	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
351627001583	dimer interface [polypeptide binding]; other site
351627001584	active site
351627001585	Predicted transcriptional regulators [Transcription]; Region: COG1733
351627001586	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627001587	dimerization interface [polypeptide binding]; other site
351627001588	putative DNA binding site [nucleotide binding]; other site
351627001589	putative Zn2+ binding site [ion binding]; other site
351627001590	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
351627001591	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351627001592	MULE transposase domain; Region: MULE; pfam10551
351627001593	LysE type translocator; Region: LysE; pfam01810
351627001594	Preprotein translocase subunit SecB; Region: SecB; pfam02556
351627001595	SecA binding site; other site
351627001596	Preprotein binding site; other site
351627001597	DNA polymerase IV; Reviewed; Region: PRK03103
351627001598	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
351627001599	active site
351627001600	DNA binding site [nucleotide binding]
351627001601	Integrase core domain; Region: rve; pfam00665
351627001602	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
351627001603	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
351627001604	putative dimer interface [polypeptide binding]; other site
351627001605	[2Fe-2S] cluster binding site [ion binding]; other site
351627001606	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
351627001607	dimer interface [polypeptide binding]; other site
351627001608	[2Fe-2S] cluster binding site [ion binding]; other site
351627001609	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
351627001610	SLBB domain; Region: SLBB; pfam10531
351627001611	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
351627001612	4Fe-4S binding domain; Region: Fer4; pfam00037
351627001613	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
351627001614	4Fe-4S binding domain; Region: Fer4; pfam00037
351627001615	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
351627001616	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351627001617	catalytic loop [active]
351627001618	iron binding site [ion binding]; other site
351627001619	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
351627001620	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
351627001621	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
351627001622	4Fe-4S binding domain; Region: Fer4; pfam00037
351627001623	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
351627001624	Formylmethanofuran dehydrogenase subunit B [Energy production and conversion]; Region: FwdB; COG1029
351627001625	molybdopterin cofactor binding site; other site
351627001626	Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186
351627001627	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
351627001628	putative active site [active]
351627001629	metal binding site [ion binding]; metal-binding site
351627001630	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351627001631	non-specific DNA binding site [nucleotide binding]; other site
351627001632	salt bridge; other site
351627001633	sequence-specific DNA binding site [nucleotide binding]; other site
351627001634	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
351627001635	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
351627001636	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
351627001637	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
351627001638	AAA ATPase domain; Region: AAA_15; pfam13175
351627001639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627001640	Walker A/P-loop; other site
351627001641	ATP binding site [chemical binding]; other site
351627001642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627001643	Walker B; other site
351627001644	D-loop; other site
351627001645	H-loop/switch region; other site
351627001646	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
351627001647	active site
351627001648	metal binding site [ion binding]; metal-binding site
351627001649	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
351627001650	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351627001651	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627001652	Walker A motif; other site
351627001653	ATP binding site [chemical binding]; other site
351627001654	Walker B motif; other site
351627001655	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627001656	dimerization interface [polypeptide binding]; other site
351627001657	putative DNA binding site [nucleotide binding]; other site
351627001658	putative Zn2+ binding site [ion binding]; other site
351627001659	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
351627001660	Low molecular weight phosphatase family; Region: LMWPc; cd00115
351627001661	active site
351627001662	SurA N-terminal domain; Region: SurA_N_3; cl07813
351627001663	Peptidase family M48; Region: Peptidase_M48; cl12018
351627001664	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351627001665	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351627001666	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
351627001667	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
351627001668	Walker A/P-loop; other site
351627001669	ATP binding site [chemical binding]; other site
351627001670	Q-loop/lid; other site
351627001671	ABC transporter signature motif; other site
351627001672	Walker B; other site
351627001673	D-loop; other site
351627001674	H-loop/switch region; other site
351627001675	Transposase domain (DUF772); Region: DUF772; pfam05598
351627001676	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627001677	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627001678	Transposase domain (DUF772); Region: DUF772; pfam05598
351627001679	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627001680	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627001681	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627001682	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
351627001683	FeS/SAM binding site; other site
351627001684	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
351627001685	CAAX protease self-immunity; Region: Abi; pfam02517
351627001686	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627001687	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627001688	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
351627001689	Walker A/P-loop; other site
351627001690	ATP binding site [chemical binding]; other site
351627001691	Q-loop/lid; other site
351627001692	ABC transporter signature motif; other site
351627001693	Walker B; other site
351627001694	D-loop; other site
351627001695	H-loop/switch region; other site
351627001696	Transposase domain (DUF772); Region: DUF772; pfam05598
351627001697	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351627001698	HlyD family secretion protein; Region: HlyD_3; pfam13437
351627001699	HlyD family secretion protein; Region: HlyD_3; pfam13437
351627001700	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
351627001701	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
351627001702	FtsX-like permease family; Region: FtsX; pfam02687
351627001703	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
351627001704	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
351627001705	Walker A/P-loop; other site
351627001706	ATP binding site [chemical binding]; other site
351627001707	Q-loop/lid; other site
351627001708	ABC transporter signature motif; other site
351627001709	Walker B; other site
351627001710	D-loop; other site
351627001711	H-loop/switch region; other site
351627001712	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
351627001713	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
351627001714	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
351627001715	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
351627001716	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
351627001717	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
351627001718	putative FMN binding site [chemical binding]; other site
351627001719	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
351627001720	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
351627001721	Flavin Reductases; Region: FlaRed; cl00801
351627001722	pullulanase, type I; Region: pulA_typeI; TIGR02104
351627001723	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
351627001724	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
351627001725	Ca binding site [ion binding]; other site
351627001726	active site
351627001727	catalytic site [active]
351627001728	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351627001729	Protein of unknown function DUF58; Region: DUF58; pfam01882
351627001730	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
351627001731	CrcB-like protein; Region: CRCB; pfam02537
351627001732	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
351627001733	toxin interface [polypeptide binding]; other site
351627001734	Zn binding site [ion binding]; other site
351627001735	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
351627001736	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
351627001737	dimer interface [polypeptide binding]; other site
351627001738	motif 1; other site
351627001739	active site
351627001740	motif 2; other site
351627001741	motif 3; other site
351627001742	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
351627001743	anticodon binding site; other site
351627001744	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
351627001745	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
351627001746	dimer interface [polypeptide binding]; other site
351627001747	anticodon binding site; other site
351627001748	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
351627001749	homodimer interface [polypeptide binding]; other site
351627001750	motif 1; other site
351627001751	active site
351627001752	motif 2; other site
351627001753	GAD domain; Region: GAD; pfam02938
351627001754	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
351627001755	motif 3; other site
351627001756	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
351627001757	Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424
351627001758	S-layer homology domain; Region: SLH; pfam00395
351627001759	S-layer homology domain; Region: SLH; pfam00395
351627001760	S-layer homology domain; Region: SLH; pfam00395
351627001761	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627001762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627001763	dimer interface [polypeptide binding]; other site
351627001764	conserved gate region; other site
351627001765	ABC-ATPase subunit interface; other site
351627001766	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627001767	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627001768	ABC-ATPase subunit interface; other site
351627001769	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627001770	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
351627001771	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627001772	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627001773	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627001774	dimerization interface [polypeptide binding]; other site
351627001775	Histidine kinase; Region: His_kinase; pfam06580
351627001776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627001777	ATP binding site [chemical binding]; other site
351627001778	Mg2+ binding site [ion binding]; other site
351627001779	G-X-G motif; other site
351627001780	Response regulator receiver domain; Region: Response_reg; pfam00072
351627001781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627001782	active site
351627001783	phosphorylation site [posttranslational modification]
351627001784	intermolecular recognition site; other site
351627001785	dimerization interface [polypeptide binding]; other site
351627001786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627001787	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627001788	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627001789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627001790	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351627001791	putative substrate translocation pore; other site
351627001792	Helix-turn-helix domain; Region: HTH_17; pfam12728
351627001793	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
351627001794	active site
351627001795	metal binding site [ion binding]; metal-binding site
351627001796	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
351627001797	non-specific DNA interactions [nucleotide binding]; other site
351627001798	DNA binding site [nucleotide binding]
351627001799	sequence specific DNA binding site [nucleotide binding]; other site
351627001800	putative cAMP binding site [chemical binding]; other site
351627001801	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
351627001802	carbohydrate binding site [chemical binding]; other site
351627001803	pullulanase, type I; Region: pulA_typeI; TIGR02104
351627001804	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
351627001805	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
351627001806	Ca binding site [ion binding]; other site
351627001807	active site
351627001808	catalytic site [active]
351627001809	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
351627001810	Starch binding domain; Region: CBM_2; smart01065
351627001811	starch-binding site 2 [chemical binding]; other site
351627001812	starch-binding site 1 [chemical binding]; other site
351627001813	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
351627001814	endonuclease III; Region: ENDO3c; smart00478
351627001815	minor groove reading motif; other site
351627001816	helix-hairpin-helix signature motif; other site
351627001817	substrate binding pocket [chemical binding]; other site
351627001818	active site
351627001819	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627001820	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
351627001821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627001822	dimer interface [polypeptide binding]; other site
351627001823	conserved gate region; other site
351627001824	putative PBP binding loops; other site
351627001825	ABC-ATPase subunit interface; other site
351627001826	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627001827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627001828	dimer interface [polypeptide binding]; other site
351627001829	conserved gate region; other site
351627001830	putative PBP binding loops; other site
351627001831	ABC-ATPase subunit interface; other site
351627001832	MarR family; Region: MarR_2; cl17246
351627001833	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
351627001834	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
351627001835	nucleotide binding site [chemical binding]; other site
351627001836	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
351627001837	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627001838	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627001839	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
351627001840	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
351627001841	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627001842	Walker A/P-loop; other site
351627001843	ATP binding site [chemical binding]; other site
351627001844	Q-loop/lid; other site
351627001845	ABC transporter signature motif; other site
351627001846	Walker B; other site
351627001847	D-loop; other site
351627001848	H-loop/switch region; other site
351627001849	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
351627001850	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
351627001851	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
351627001852	MoxR-like ATPases [General function prediction only]; Region: COG0714
351627001853	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627001854	Walker A motif; other site
351627001855	ATP binding site [chemical binding]; other site
351627001856	Walker B motif; other site
351627001857	arginine finger; other site
351627001858	Protein of unknown function DUF58; Region: DUF58; pfam01882
351627001859	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
351627001860	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
351627001861	metal ion-dependent adhesion site (MIDAS); other site
351627001862	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
351627001863	metal ion-dependent adhesion site (MIDAS); other site
351627001864	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
351627001865	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
351627001866	metal ion-dependent adhesion site (MIDAS); other site
351627001867	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
351627001868	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
351627001869	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
351627001870	active site
351627001871	HIGH motif; other site
351627001872	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
351627001873	active site
351627001874	KMSKS motif; other site
351627001875	serine O-acetyltransferase; Region: cysE; TIGR01172
351627001876	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
351627001877	trimer interface [polypeptide binding]; other site
351627001878	active site
351627001879	substrate binding site [chemical binding]; other site
351627001880	CoA binding site [chemical binding]; other site
351627001881	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
351627001882	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
351627001883	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
351627001884	active site
351627001885	HIGH motif; other site
351627001886	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
351627001887	KMSKS motif; other site
351627001888	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
351627001889	tRNA binding surface [nucleotide binding]; other site
351627001890	anticodon binding site; other site
351627001891	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
351627001892	putative active site pocket [active]
351627001893	dimerization interface [polypeptide binding]; other site
351627001894	putative catalytic residue [active]
351627001895	Predicted transcriptional regulators [Transcription]; Region: COG1733
351627001896	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
351627001897	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
351627001898	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
351627001899	putative active site [active]
351627001900	metal binding site [ion binding]; metal-binding site
351627001901	Integrase core domain; Region: rve; pfam00665
351627001902	Amino acid permease; Region: AA_permease_2; pfam13520
351627001903	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
351627001904	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
351627001905	Cl- selectivity filter; other site
351627001906	Cl- binding residues [ion binding]; other site
351627001907	pore gating glutamate residue; other site
351627001908	dimer interface [polypeptide binding]; other site
351627001909	H+/Cl- coupling transport residue; other site
351627001910	TrkA-C domain; Region: TrkA_C; pfam02080
351627001911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
351627001912	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
351627001913	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
351627001914	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
351627001915	putative active site [active]
351627001916	putative metal binding site [ion binding]; other site
351627001917	ribulokinase; Provisional; Region: PRK04123
351627001918	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
351627001919	N- and C-terminal domain interface [polypeptide binding]; other site
351627001920	active site
351627001921	MgATP binding site [chemical binding]; other site
351627001922	catalytic site [active]
351627001923	metal binding site [ion binding]; metal-binding site
351627001924	carbohydrate binding site [chemical binding]; other site
351627001925	homodimer interface [polypeptide binding]; other site
351627001926	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351627001927	DNA-binding site [nucleotide binding]; DNA binding site
351627001928	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627001929	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
351627001930	putative dimerization interface [polypeptide binding]; other site
351627001931	putative ligand binding site [chemical binding]; other site
351627001932	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
351627001933	intersubunit interface [polypeptide binding]; other site
351627001934	active site
351627001935	Zn2+ binding site [ion binding]; other site
351627001936	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
351627001937	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
351627001938	active site
351627001939	catalytic residues [active]
351627001940	metal binding site [ion binding]; metal-binding site
351627001941	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
351627001942	4Fe-4S binding domain; Region: Fer4; pfam00037
351627001943	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
351627001944	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
351627001945	glutamine binding [chemical binding]; other site
351627001946	catalytic triad [active]
351627001947	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
351627001948	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
351627001949	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
351627001950	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
351627001951	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
351627001952	substrate-cofactor binding pocket; other site
351627001953	homodimer interface [polypeptide binding]; other site
351627001954	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627001955	catalytic residue [active]
351627001956	FMN-binding domain; Region: FMN_bind; cl01081
351627001957	4Fe-4S binding domain; Region: Fer4_5; pfam12801
351627001958	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
351627001959	ApbE family; Region: ApbE; pfam02424
351627001960	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351627001961	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351627001962	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
351627001963	Penicillinase repressor; Region: Pencillinase_R; pfam03965
351627001964	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
351627001965	4Fe-4S binding domain; Region: Fer4; cl02805
351627001966	Fumarase C-terminus; Region: Fumerase_C; pfam05683
351627001967	Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276
351627001968	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
351627001969	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351627001970	catalytic residue [active]
351627001971	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
351627001972	thymidylate kinase; Validated; Region: tmk; PRK00698
351627001973	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
351627001974	TMP-binding site; other site
351627001975	ATP-binding site [chemical binding]; other site
351627001976	Protein of unknown function (DUF970); Region: DUF970; pfam06153
351627001977	Protein of unknown function (DUF327); Region: DUF327; pfam03885
351627001978	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
351627001979	DNA polymerase III subunit delta'; Validated; Region: PRK08485
351627001980	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
351627001981	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
351627001982	RmuC family; Region: RmuC; pfam02646
351627001983	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
351627001984	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
351627001985	active site
351627001986	catalytic residues [active]
351627001987	metal binding site [ion binding]; metal-binding site
351627001988	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
351627001989	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627001990	Walker A/P-loop; other site
351627001991	ATP binding site [chemical binding]; other site
351627001992	Q-loop/lid; other site
351627001993	ABC transporter signature motif; other site
351627001994	Walker B; other site
351627001995	D-loop; other site
351627001996	H-loop/switch region; other site
351627001997	aconitate hydratase; Validated; Region: PRK07229
351627001998	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
351627001999	substrate binding site [chemical binding]; other site
351627002000	ligand binding site [chemical binding]; other site
351627002001	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
351627002002	substrate binding site [chemical binding]; other site
351627002003	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
351627002004	isocitrate dehydrogenase; Validated; Region: PRK06451
351627002005	Transcriptional regulators [Transcription]; Region: GntR; COG1802
351627002006	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351627002007	DNA-binding site [nucleotide binding]; DNA binding site
351627002008	FCD domain; Region: FCD; pfam07729
351627002009	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
351627002010	ATP-grasp domain; Region: ATP-grasp_4; cl17255
351627002011	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351627002012	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351627002013	metal binding site [ion binding]; metal-binding site
351627002014	active site
351627002015	I-site; other site
351627002016	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
351627002017	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
351627002018	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
351627002019	active site
351627002020	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
351627002021	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351627002022	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
351627002023	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
351627002024	active site residue [active]
351627002025	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
351627002026	Domain of unknown function (DUF348); Region: DUF348; pfam03990
351627002027	Domain of unknown function (DUF348); Region: DUF348; pfam03990
351627002028	G5 domain; Region: G5; pfam07501
351627002029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
351627002030	Domain of unknown function (DUF377); Region: DUF377; pfam04041
351627002031	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
351627002032	active site
351627002033	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
351627002034	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
351627002035	putative NAD(P) binding site [chemical binding]; other site
351627002036	catalytic Zn binding site [ion binding]; other site
351627002037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627002038	ATP binding site [chemical binding]; other site
351627002039	Mg2+ binding site [ion binding]; other site
351627002040	G-X-G motif; other site
351627002041	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
351627002042	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
351627002043	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
351627002044	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
351627002045	substrate binding site [chemical binding]; other site
351627002046	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
351627002047	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
351627002048	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
351627002049	substrate binding site [chemical binding]; other site
351627002050	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
351627002051	nucleotide binding site [chemical binding]; other site
351627002052	Type III pantothenate kinase; Region: Pan_kinase; cl17198
351627002053	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
351627002054	aspartate aminotransferase; Provisional; Region: PRK06290
351627002055	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351627002056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627002057	homodimer interface [polypeptide binding]; other site
351627002058	catalytic residue [active]
351627002059	4Fe-4S binding domain; Region: Fer4_5; pfam12801
351627002060	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351627002061	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
351627002062	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
351627002063	ATP cone domain; Region: ATP-cone; pfam03477
351627002064	Class III ribonucleotide reductase; Region: RNR_III; cd01675
351627002065	effector binding site; other site
351627002066	active site
351627002067	Zn binding site [ion binding]; other site
351627002068	glycine loop; other site
351627002069	2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275
351627002070	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
351627002071	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
351627002072	nucleotide binding site [chemical binding]; other site
351627002073	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
351627002074	active site
351627002075	catalytic triad [active]
351627002076	oxyanion hole [active]
351627002077	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
351627002078	homodimer interface [polypeptide binding]; other site
351627002079	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
351627002080	active site pocket [active]
351627002081	glycogen synthase; Provisional; Region: glgA; PRK00654
351627002082	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
351627002083	ADP-binding pocket [chemical binding]; other site
351627002084	homodimer interface [polypeptide binding]; other site
351627002085	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
351627002086	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
351627002087	ligand binding site; other site
351627002088	oligomer interface; other site
351627002089	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
351627002090	dimer interface [polypeptide binding]; other site
351627002091	N-terminal domain interface [polypeptide binding]; other site
351627002092	sulfate 1 binding site; other site
351627002093	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
351627002094	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
351627002095	ligand binding site; other site
351627002096	oligomer interface; other site
351627002097	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
351627002098	dimer interface [polypeptide binding]; other site
351627002099	N-terminal domain interface [polypeptide binding]; other site
351627002100	sulfate 1 binding site; other site
351627002101	glycogen branching enzyme; Provisional; Region: PRK12313
351627002102	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
351627002103	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
351627002104	active site
351627002105	catalytic site [active]
351627002106	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
351627002107	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
351627002108	EamA-like transporter family; Region: EamA; pfam00892
351627002109	EamA-like transporter family; Region: EamA; pfam00892
351627002110	H+ Antiporter protein; Region: 2A0121; TIGR00900
351627002111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627002112	putative substrate translocation pore; other site
351627002113	hypothetical protein; Reviewed; Region: PRK00024
351627002114	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
351627002115	MPN+ (JAMM) motif; other site
351627002116	Zinc-binding site [ion binding]; other site
351627002117	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
351627002118	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351627002119	Bacterial SH3 domain; Region: SH3_3; pfam08239
351627002120	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351627002121	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627002122	active site
351627002123	NTP binding site [chemical binding]; other site
351627002124	metal binding triad [ion binding]; metal-binding site
351627002125	antibiotic binding site [chemical binding]; other site
351627002126	HEPN domain; Region: HEPN; pfam05168
351627002127	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
351627002128	homopentamer interface [polypeptide binding]; other site
351627002129	active site
351627002130	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
351627002131	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
351627002132	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
351627002133	dimerization interface [polypeptide binding]; other site
351627002134	active site
351627002135	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
351627002136	Lumazine binding domain; Region: Lum_binding; pfam00677
351627002137	Lumazine binding domain; Region: Lum_binding; pfam00677
351627002138	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
351627002139	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
351627002140	catalytic motif [active]
351627002141	Zn binding site [ion binding]; other site
351627002142	RibD C-terminal domain; Region: RibD_C; cl17279
351627002143	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
351627002144	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627002145	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351627002146	DNA binding site [nucleotide binding]
351627002147	domain linker motif; other site
351627002148	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
351627002149	dimerization interface [polypeptide binding]; other site
351627002150	ligand binding site [chemical binding]; other site
351627002151	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
351627002152	N- and C-terminal domain interface [polypeptide binding]; other site
351627002153	D-xylulose kinase; Region: XylB; TIGR01312
351627002154	active site
351627002155	MgATP binding site [chemical binding]; other site
351627002156	catalytic site [active]
351627002157	metal binding site [ion binding]; metal-binding site
351627002158	xylulose binding site [chemical binding]; other site
351627002159	homodimer interface [polypeptide binding]; other site
351627002160	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
351627002161	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627002162	Zn2+ binding site [ion binding]; other site
351627002163	Mg2+ binding site [ion binding]; other site
351627002164	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
351627002165	ANTAR domain; Region: ANTAR; pfam03861
351627002166	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
351627002167	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
351627002168	catalytic triad [active]
351627002169	Mechanosensitive ion channel; Region: MS_channel; pfam00924
351627002170	prolyl-tRNA synthetase; Provisional; Region: PRK09194
351627002171	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
351627002172	dimer interface [polypeptide binding]; other site
351627002173	motif 1; other site
351627002174	active site
351627002175	motif 2; other site
351627002176	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
351627002177	putative deacylase active site [active]
351627002178	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
351627002179	active site
351627002180	motif 3; other site
351627002181	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
351627002182	anticodon binding site; other site
351627002183	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
351627002184	Cache domain; Region: Cache_2; cl07034
351627002185	Transposase domain (DUF772); Region: DUF772; pfam05598
351627002186	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627002187	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627002188	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
351627002189	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351627002190	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
351627002191	putative binding surface; other site
351627002192	active site
351627002193	P2 response regulator binding domain; Region: P2; pfam07194
351627002194	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
351627002195	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627002196	ATP binding site [chemical binding]; other site
351627002197	Mg2+ binding site [ion binding]; other site
351627002198	G-X-G motif; other site
351627002199	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
351627002200	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
351627002201	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627002202	Zn2+ binding site [ion binding]; other site
351627002203	Mg2+ binding site [ion binding]; other site
351627002204	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627002205	dimer interface [polypeptide binding]; other site
351627002206	putative CheW interface [polypeptide binding]; other site
351627002207	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627002208	dimer interface [polypeptide binding]; other site
351627002209	putative CheW interface [polypeptide binding]; other site
351627002210	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
351627002211	putative CheA interaction surface; other site
351627002212	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
351627002213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627002214	active site
351627002215	phosphorylation site [posttranslational modification]
351627002216	intermolecular recognition site; other site
351627002217	dimerization interface [polypeptide binding]; other site
351627002218	CheB methylesterase; Region: CheB_methylest; pfam01339
351627002219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351627002220	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
351627002221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627002222	ATP binding site [chemical binding]; other site
351627002223	Mg2+ binding site [ion binding]; other site
351627002224	G-X-G motif; other site
351627002225	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
351627002226	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
351627002227	HEAT repeats; Region: HEAT_2; pfam13646
351627002228	protein binding surface [polypeptide binding]; other site
351627002229	HEAT repeats; Region: HEAT_2; pfam13646
351627002230	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
351627002231	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
351627002232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627002233	S-adenosylmethionine binding site [chemical binding]; other site
351627002234	Response regulator receiver domain; Region: Response_reg; pfam00072
351627002235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627002236	active site
351627002237	phosphorylation site [posttranslational modification]
351627002238	intermolecular recognition site; other site
351627002239	dimerization interface [polypeptide binding]; other site
351627002240	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351627002241	putative binding surface; other site
351627002242	active site
351627002243	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
351627002244	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627002245	dimer interface [polypeptide binding]; other site
351627002246	putative CheW interface [polypeptide binding]; other site
351627002247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627002248	Response regulator receiver domain; Region: Response_reg; pfam00072
351627002249	active site
351627002250	phosphorylation site [posttranslational modification]
351627002251	intermolecular recognition site; other site
351627002252	dimerization interface [polypeptide binding]; other site
351627002253	PAS domain; Region: PAS_9; pfam13426
351627002254	PAS domain; Region: PAS; smart00091
351627002255	putative active site [active]
351627002256	heme pocket [chemical binding]; other site
351627002257	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351627002258	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351627002259	metal binding site [ion binding]; metal-binding site
351627002260	active site
351627002261	I-site; other site
351627002262	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
351627002263	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627002264	active site
351627002265	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
351627002266	salt bridge; other site
351627002267	sequence-specific DNA binding site [nucleotide binding]; other site
351627002268	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
351627002269	Cation efflux family; Region: Cation_efflux; pfam01545
351627002270	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
351627002271	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
351627002272	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
351627002273	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
351627002274	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
351627002275	dimer interface [polypeptide binding]; other site
351627002276	putative anticodon binding site; other site
351627002277	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
351627002278	motif 1; other site
351627002279	active site
351627002280	motif 2; other site
351627002281	motif 3; other site
351627002282	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
351627002283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
351627002284	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
351627002285	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
351627002286	DNA binding residues [nucleotide binding]
351627002287	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
351627002288	catalytic nucleophile [active]
351627002289	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
351627002290	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
351627002291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
351627002292	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
351627002293	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
351627002294	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cd03873
351627002295	metal binding site [ion binding]; metal-binding site
351627002296	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
351627002297	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
351627002298	homodimer interface [polypeptide binding]; other site
351627002299	substrate-cofactor binding pocket; other site
351627002300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627002301	catalytic residue [active]
351627002302	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
351627002303	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
351627002304	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
351627002305	PYR/PP interface [polypeptide binding]; other site
351627002306	dimer interface [polypeptide binding]; other site
351627002307	TPP binding site [chemical binding]; other site
351627002308	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351627002309	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
351627002310	TPP-binding site [chemical binding]; other site
351627002311	dimer interface [polypeptide binding]; other site
351627002312	VanZ like family; Region: VanZ; cl01971
351627002313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627002314	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351627002315	Walker A motif; other site
351627002316	ATP binding site [chemical binding]; other site
351627002317	Walker B motif; other site
351627002318	arginine finger; other site
351627002319	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627002320	MULE transposase domain; Region: MULE; pfam10551
351627002321	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627002322	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351627002323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627002324	MULE transposase domain; Region: MULE; pfam10551
351627002325	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627002326	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627002327	Homeodomain-like domain; Region: HTH_23; pfam13384
351627002328	Integrase core domain; Region: rve; pfam00665
351627002329	Transposase, Mutator family; Region: Transposase_mut; pfam00872
351627002330	Putative amidase domain; Region: Amidase_6; pfam12671
351627002331	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
351627002332	Domain of unknown function (DUF377); Region: DUF377; pfam04041
351627002333	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
351627002334	active site
351627002335	Uncharacterized conserved protein [Function unknown]; Region: COG0432
351627002336	Integrase core domain; Region: rve; pfam00665
351627002337	S-adenosylmethionine synthetase; Validated; Region: PRK05250
351627002338	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
351627002339	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
351627002340	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
351627002341	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
351627002342	DHH family; Region: DHH; pfam01368
351627002343	DHHA1 domain; Region: DHHA1; pfam02272
351627002344	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
351627002345	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
351627002346	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
351627002347	Protein of unknown function (DUF964); Region: DUF964; pfam06133
351627002348	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
351627002349	Uncharacterized conserved protein [Function unknown]; Region: COG1615
351627002350	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
351627002351	intersubunit interface [polypeptide binding]; other site
351627002352	active site
351627002353	Zn2+ binding site [ion binding]; other site
351627002354	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
351627002355	intersubunit interface [polypeptide binding]; other site
351627002356	active site
351627002357	Zn2+ binding site [ion binding]; other site
351627002358	Uncharacterized conserved protein [Function unknown]; Region: COG3347
351627002359	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
351627002360	intersubunit interface [polypeptide binding]; other site
351627002361	active site
351627002362	Zn2+ binding site [ion binding]; other site
351627002363	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
351627002364	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
351627002365	active site
351627002366	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
351627002367	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351627002368	NAD(P) binding site [chemical binding]; other site
351627002369	active site
351627002370	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
351627002371	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
351627002372	putative NAD(P) binding site [chemical binding]; other site
351627002373	catalytic Zn binding site [ion binding]; other site
351627002374	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
351627002375	lipoyl synthase; Provisional; Region: PRK05481
351627002376	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627002377	FeS/SAM binding site; other site
351627002378	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
351627002379	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
351627002380	E3 interaction surface; other site
351627002381	lipoyl attachment site [posttranslational modification]; other site
351627002382	e3 binding domain; Region: E3_binding; pfam02817
351627002383	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
351627002384	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
351627002385	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
351627002386	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351627002387	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
351627002388	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
351627002389	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
351627002390	tetramer interface [polypeptide binding]; other site
351627002391	TPP-binding site [chemical binding]; other site
351627002392	heterodimer interface [polypeptide binding]; other site
351627002393	phosphorylation loop region [posttranslational modification]
351627002394	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
351627002395	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
351627002396	alpha subunit interface [polypeptide binding]; other site
351627002397	TPP binding site [chemical binding]; other site
351627002398	heterodimer interface [polypeptide binding]; other site
351627002399	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
351627002400	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
351627002401	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
351627002402	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
351627002403	L-rhamnose isomerase; Provisional; Region: PRK01076
351627002404	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
351627002405	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
351627002406	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
351627002407	hexamer (dimer of trimers) interface [polypeptide binding]; other site
351627002408	substrate binding site [chemical binding]; other site
351627002409	trimer interface [polypeptide binding]; other site
351627002410	Mn binding site [ion binding]; other site
351627002411	trigger factor; Provisional; Region: tig; PRK01490
351627002412	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
351627002413	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
351627002414	Clp protease; Region: CLP_protease; pfam00574
351627002415	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
351627002416	oligomer interface [polypeptide binding]; other site
351627002417	active site residues [active]
351627002418	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
351627002419	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
351627002420	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627002421	Walker A motif; other site
351627002422	ATP binding site [chemical binding]; other site
351627002423	Walker B motif; other site
351627002424	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
351627002425	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
351627002426	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627002427	Zn2+ binding site [ion binding]; other site
351627002428	Mg2+ binding site [ion binding]; other site
351627002429	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
351627002430	DNA primase; Validated; Region: dnaG; PRK05667
351627002431	CHC2 zinc finger; Region: zf-CHC2; pfam01807
351627002432	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
351627002433	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
351627002434	active site
351627002435	metal binding site [ion binding]; metal-binding site
351627002436	interdomain interaction site; other site
351627002437	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
351627002438	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
351627002439	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
351627002440	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
351627002441	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627002442	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
351627002443	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627002444	DNA binding residues [nucleotide binding]
351627002445	Homeobox associated leucine zipper; Region: HALZ; pfam02183
351627002446	NPCBM/NEW2 domain; Region: NPCBM; cl07060
351627002447	Predicted membrane protein [Function unknown]; Region: COG4640
351627002448	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
351627002449	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627002450	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627002451	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627002452	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627002453	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627002454	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
351627002455	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627002456	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627002457	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627002458	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
351627002459	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
351627002460	YceG-like family; Region: YceG; pfam02618
351627002461	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
351627002462	dimerization interface [polypeptide binding]; other site
351627002463	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
351627002464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627002465	S-adenosylmethionine binding site [chemical binding]; other site
351627002466	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
351627002467	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782
351627002468	Peptidase family U32; Region: Peptidase_U32; pfam01136
351627002469	sporulation sigma factor SigK; Reviewed; Region: PRK05803
351627002470	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627002471	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627002472	DNA binding residues [nucleotide binding]
351627002473	Protein of unknown function (DUF402); Region: DUF402; pfam04167
351627002474	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
351627002475	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
351627002476	substrate binding pocket [chemical binding]; other site
351627002477	dimer interface [polypeptide binding]; other site
351627002478	inhibitor binding site; inhibition site
351627002479	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
351627002480	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
351627002481	Protein of unknown function (DUF512); Region: DUF512; pfam04459
351627002482	GTP-binding protein Der; Reviewed; Region: PRK00093
351627002483	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
351627002484	G1 box; other site
351627002485	GTP/Mg2+ binding site [chemical binding]; other site
351627002486	Switch I region; other site
351627002487	G2 box; other site
351627002488	Switch II region; other site
351627002489	G3 box; other site
351627002490	G4 box; other site
351627002491	G5 box; other site
351627002492	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
351627002493	G1 box; other site
351627002494	GTP/Mg2+ binding site [chemical binding]; other site
351627002495	Switch I region; other site
351627002496	G2 box; other site
351627002497	G3 box; other site
351627002498	Switch II region; other site
351627002499	G4 box; other site
351627002500	G5 box; other site
351627002501	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
351627002502	Methyltransferase domain; Region: Methyltransf_31; pfam13847
351627002503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627002504	S-adenosylmethionine binding site [chemical binding]; other site
351627002505	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
351627002506	DNA-binding site [nucleotide binding]; DNA binding site
351627002507	RNA-binding motif; other site
351627002508	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
351627002509	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
351627002510	dimerization interface [polypeptide binding]; other site
351627002511	domain crossover interface; other site
351627002512	redox-dependent activation switch; other site
351627002513	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
351627002514	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
351627002515	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
351627002516	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
351627002517	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
351627002518	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
351627002519	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
351627002520	GatB domain; Region: GatB_Yqey; smart00845
351627002521	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627002522	active site
351627002523	NTP binding site [chemical binding]; other site
351627002524	metal binding triad [ion binding]; metal-binding site
351627002525	antibiotic binding site [chemical binding]; other site
351627002526	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
351627002527	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
351627002528	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
351627002529	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
351627002530	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
351627002531	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
351627002532	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
351627002533	cell division protein MraZ; Reviewed; Region: PRK00326
351627002534	MraZ protein; Region: MraZ; pfam02381
351627002535	MraZ protein; Region: MraZ; pfam02381
351627002536	MraW methylase family; Region: Methyltransf_5; pfam01795
351627002537	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
351627002538	Septum formation initiator; Region: DivIC; cl17659
351627002539	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
351627002540	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
351627002541	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
351627002542	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
351627002543	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
351627002544	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
351627002545	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
351627002546	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351627002547	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
351627002548	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
351627002549	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
351627002550	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351627002551	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
351627002552	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
351627002553	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
351627002554	Mg++ binding site [ion binding]; other site
351627002555	putative catalytic motif [active]
351627002556	putative substrate binding site [chemical binding]; other site
351627002557	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
351627002558	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
351627002559	NAD binding site [chemical binding]; other site
351627002560	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351627002561	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
351627002562	cell division protein FtsW; Region: ftsW; TIGR02614
351627002563	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
351627002564	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
351627002565	active site
351627002566	homodimer interface [polypeptide binding]; other site
351627002567	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
351627002568	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
351627002569	hinge; other site
351627002570	active site
351627002571	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
351627002572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
351627002573	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
351627002574	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
351627002575	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
351627002576	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
351627002577	nucleotide binding site [chemical binding]; other site
351627002578	SulA interaction site; other site
351627002579	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
351627002580	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
351627002581	sporulation sigma factor SigE; Reviewed; Region: PRK08301
351627002582	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627002583	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627002584	DNA binding residues [nucleotide binding]
351627002585	sporulation sigma factor SigG; Reviewed; Region: PRK08215
351627002586	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627002587	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
351627002588	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627002589	DNA binding residues [nucleotide binding]
351627002590	AMP-binding domain protein; Validated; Region: PRK08315
351627002591	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351627002592	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
351627002593	acyl-activating enzyme (AAE) consensus motif; other site
351627002594	acyl-activating enzyme (AAE) consensus motif; other site
351627002595	putative AMP binding site [chemical binding]; other site
351627002596	putative active site [active]
351627002597	putative CoA binding site [chemical binding]; other site
351627002598	diaminopimelate decarboxylase; Region: lysA; TIGR01048
351627002599	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
351627002600	active site
351627002601	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351627002602	substrate binding site [chemical binding]; other site
351627002603	catalytic residues [active]
351627002604	dimer interface [polypeptide binding]; other site
351627002605	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
351627002606	Peptidase family M50; Region: Peptidase_M50; pfam02163
351627002607	active site
351627002608	putative substrate binding region [chemical binding]; other site
351627002609	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
351627002610	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
351627002611	active site
351627002612	HIGH motif; other site
351627002613	dimer interface [polypeptide binding]; other site
351627002614	KMSKS motif; other site
351627002615	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
351627002616	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
351627002617	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
351627002618	Peptidase family M23; Region: Peptidase_M23; pfam01551
351627002619	Integrase core domain; Region: rve; pfam00665
351627002620	CHASE4 domain; Region: CHASE4; cl01308
351627002621	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
351627002622	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627002623	Zn2+ binding site [ion binding]; other site
351627002624	Mg2+ binding site [ion binding]; other site
351627002625	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
351627002626	Divergent AAA domain; Region: AAA_4; pfam04326
351627002627	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
351627002628	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351627002629	binding surface
351627002630	Tetratricopeptide repeat; Region: TPR_16; pfam13432
351627002631	TPR motif; other site
351627002632	Tetratricopeptide repeat; Region: TPR_16; pfam13432
351627002633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351627002634	binding surface
351627002635	TPR repeat; Region: TPR_11; pfam13414
351627002636	TPR motif; other site
351627002637	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
351627002638	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
351627002639	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
351627002640	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
351627002641	active site
351627002642	dimer interface [polypeptide binding]; other site
351627002643	motif 1; other site
351627002644	motif 2; other site
351627002645	motif 3; other site
351627002646	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
351627002647	anticodon binding site; other site
351627002648	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
351627002649	active site
351627002650	metal binding site [ion binding]; metal-binding site
351627002651	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
351627002652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627002653	active site
351627002654	phosphorylation site [posttranslational modification]
351627002655	intermolecular recognition site; other site
351627002656	CheB methylesterase; Region: CheB_methylest; pfam01339
351627002657	Integrase core domain; Region: rve; pfam00665
351627002658	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
351627002659	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
351627002660	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
351627002661	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
351627002662	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
351627002663	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
351627002664	RPB1 interaction site [polypeptide binding]; other site
351627002665	RPB10 interaction site [polypeptide binding]; other site
351627002666	RPB11 interaction site [polypeptide binding]; other site
351627002667	RPB3 interaction site [polypeptide binding]; other site
351627002668	RPB12 interaction site [polypeptide binding]; other site
351627002669	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
351627002670	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
351627002671	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
351627002672	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
351627002673	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
351627002674	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
351627002675	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
351627002676	G-loop; other site
351627002677	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
351627002678	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
351627002679	DNA binding site [nucleotide binding]
351627002680	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
351627002681	Integrase core domain; Region: rve; pfam00665
351627002682	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
351627002683	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
351627002684	S17 interaction site [polypeptide binding]; other site
351627002685	S8 interaction site; other site
351627002686	16S rRNA interaction site [nucleotide binding]; other site
351627002687	streptomycin interaction site [chemical binding]; other site
351627002688	23S rRNA interaction site [nucleotide binding]; other site
351627002689	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
351627002690	30S ribosomal protein S7; Validated; Region: PRK05302
351627002691	elongation factor G; Reviewed; Region: PRK00007
351627002692	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
351627002693	G1 box; other site
351627002694	putative GEF interaction site [polypeptide binding]; other site
351627002695	GTP/Mg2+ binding site [chemical binding]; other site
351627002696	Switch I region; other site
351627002697	G2 box; other site
351627002698	G3 box; other site
351627002699	Switch II region; other site
351627002700	G4 box; other site
351627002701	G5 box; other site
351627002702	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
351627002703	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
351627002704	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
351627002705	elongation factor Tu; Reviewed; Region: PRK00049
351627002706	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
351627002707	G1 box; other site
351627002708	GEF interaction site [polypeptide binding]; other site
351627002709	GTP/Mg2+ binding site [chemical binding]; other site
351627002710	Switch I region; other site
351627002711	G2 box; other site
351627002712	G3 box; other site
351627002713	Switch II region; other site
351627002714	G4 box; other site
351627002715	G5 box; other site
351627002716	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
351627002717	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
351627002718	Antibiotic Binding Site [chemical binding]; other site
351627002719	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
351627002720	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
351627002721	HflX GTPase family; Region: HflX; cd01878
351627002722	G1 box; other site
351627002723	GTP/Mg2+ binding site [chemical binding]; other site
351627002724	Switch I region; other site
351627002725	G2 box; other site
351627002726	G3 box; other site
351627002727	Switch II region; other site
351627002728	G4 box; other site
351627002729	G5 box; other site
351627002730	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
351627002731	active site
351627002732	Ap6A binding site [chemical binding]; other site
351627002733	nudix motif; other site
351627002734	metal binding site [ion binding]; metal-binding site
351627002735	Uncharacterized conserved protein [Function unknown]; Region: COG1739
351627002736	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
351627002737	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
351627002738	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
351627002739	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
351627002740	hypothetical protein; Validated; Region: PRK00110
351627002741	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
351627002742	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
351627002743	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
351627002744	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
351627002745	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
351627002746	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790
351627002747	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
351627002748	hypothetical protein; Provisional; Region: PRK08328
351627002749	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
351627002750	ATP binding site [chemical binding]; other site
351627002751	substrate interface [chemical binding]; other site
351627002752	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
351627002753	PBP superfamily domain; Region: PBP_like_2; pfam12849
351627002754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627002755	dimer interface [polypeptide binding]; other site
351627002756	conserved gate region; other site
351627002757	putative PBP binding loops; other site
351627002758	ABC-ATPase subunit interface; other site
351627002759	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
351627002760	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627002761	Walker A/P-loop; other site
351627002762	ATP binding site [chemical binding]; other site
351627002763	Q-loop/lid; other site
351627002764	ABC transporter signature motif; other site
351627002765	Walker B; other site
351627002766	D-loop; other site
351627002767	H-loop/switch region; other site
351627002768	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
351627002769	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
351627002770	dimer interface [polypeptide binding]; other site
351627002771	putative functional site; other site
351627002772	putative MPT binding site; other site
351627002773	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
351627002774	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
351627002775	dimer interface [polypeptide binding]; other site
351627002776	putative functional site; other site
351627002777	putative MPT binding site; other site
351627002778	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
351627002779	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627002780	FeS/SAM binding site; other site
351627002781	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
351627002782	molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499
351627002783	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
351627002784	trimer interface [polypeptide binding]; other site
351627002785	dimer interface [polypeptide binding]; other site
351627002786	putative active site [active]
351627002787	MOSC domain; Region: MOSC; pfam03473
351627002788	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
351627002789	MPT binding site; other site
351627002790	trimer interface [polypeptide binding]; other site
351627002791	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
351627002792	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
351627002793	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
351627002794	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
351627002795	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
351627002796	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
351627002797	Mg++ binding site [ion binding]; other site
351627002798	putative catalytic motif [active]
351627002799	substrate binding site [chemical binding]; other site
351627002800	Sporulation and spore germination; Region: Germane; pfam10646
351627002801	ribonuclease PH; Reviewed; Region: rph; PRK00173
351627002802	Ribonuclease PH; Region: RNase_PH_bact; cd11362
351627002803	hexamer interface [polypeptide binding]; other site
351627002804	active site
351627002805	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
351627002806	active site
351627002807	dimerization interface [polypeptide binding]; other site
351627002808	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
351627002809	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
351627002810	active site
351627002811	metal binding site [ion binding]; metal-binding site
351627002812	homotetramer interface [polypeptide binding]; other site
351627002813	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
351627002814	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
351627002815	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
351627002816	N- and C-terminal domain interface [polypeptide binding]; other site
351627002817	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
351627002818	active site
351627002819	putative catalytic site [active]
351627002820	metal binding site [ion binding]; metal-binding site
351627002821	ATP binding site [chemical binding]; other site
351627002822	carbohydrate binding site [chemical binding]; other site
351627002823	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
351627002824	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
351627002825	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
351627002826	aspartate kinase; Reviewed; Region: PRK06635
351627002827	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
351627002828	putative catalytic residues [active]
351627002829	putative nucleotide binding site [chemical binding]; other site
351627002830	putative aspartate binding site [chemical binding]; other site
351627002831	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
351627002832	putative allosteric regulatory site; other site
351627002833	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
351627002834	putative allosteric regulatory residue; other site
351627002835	homoserine kinase; Provisional; Region: PRK01212
351627002836	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
351627002837	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
351627002838	homoserine dehydrogenase; Provisional; Region: PRK06349
351627002839	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
351627002840	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
351627002841	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
351627002842	hypothetical protein; Provisional; Region: PRK04435
351627002843	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
351627002844	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
351627002845	Spore germination protein; Region: Spore_permease; cl17796
351627002846	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
351627002847	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
351627002848	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
351627002849	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627002850	active site
351627002851	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
351627002852	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627002853	Zn2+ binding site [ion binding]; other site
351627002854	Mg2+ binding site [ion binding]; other site
351627002855	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
351627002856	synthetase active site [active]
351627002857	NTP binding site [chemical binding]; other site
351627002858	metal binding site [ion binding]; metal-binding site
351627002859	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
351627002860	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
351627002861	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
351627002862	putative active site [active]
351627002863	dimerization interface [polypeptide binding]; other site
351627002864	putative tRNAtyr binding site [nucleotide binding]; other site
351627002865	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
351627002866	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
351627002867	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627002868	FeS/SAM binding site; other site
351627002869	Radical SAM superfamily; Region: Radical_SAM; pfam04055
351627002870	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627002871	FeS/SAM binding site; other site
351627002872	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
351627002873	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
351627002874	active site
351627002875	homodimer interface [polypeptide binding]; other site
351627002876	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
351627002877	Interdomain contacts; other site
351627002878	Cytokine receptor motif; other site
351627002879	Fibronectin type 3 domain; Region: FN3; smart00060
351627002880	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
351627002881	Interdomain contacts; other site
351627002882	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
351627002883	Interdomain contacts; other site
351627002884	Cytokine receptor motif; other site
351627002885	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
351627002886	Interdomain contacts; other site
351627002887	Cytokine receptor motif; other site
351627002888	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
351627002889	Interdomain contacts; other site
351627002890	Cytokine receptor motif; other site
351627002891	S-layer homology domain; Region: SLH; pfam00395
351627002892	S-layer homology domain; Region: SLH; pfam00395
351627002893	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
351627002894	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
351627002895	substrate binding pocket [chemical binding]; other site
351627002896	membrane-bound complex binding site; other site
351627002897	hinge residues; other site
351627002898	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
351627002899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627002900	dimer interface [polypeptide binding]; other site
351627002901	conserved gate region; other site
351627002902	putative PBP binding loops; other site
351627002903	ABC-ATPase subunit interface; other site
351627002904	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
351627002905	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
351627002906	Walker A/P-loop; other site
351627002907	ATP binding site [chemical binding]; other site
351627002908	Q-loop/lid; other site
351627002909	ABC transporter signature motif; other site
351627002910	Walker B; other site
351627002911	D-loop; other site
351627002912	H-loop/switch region; other site
351627002913	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
351627002914	EamA-like transporter family; Region: EamA; pfam00892
351627002915	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
351627002916	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
351627002917	Beta-Casp domain; Region: Beta-Casp; smart01027
351627002918	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
351627002919	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
351627002920	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
351627002921	Abhydrolase family; Region: Abhydrolase_7; pfam12715
351627002922	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
351627002923	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
351627002924	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
351627002925	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
351627002926	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
351627002927	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
351627002928	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627002929	FeS/SAM binding site; other site
351627002930	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
351627002931	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
351627002932	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
351627002933	hydroxyglutarate oxidase; Provisional; Region: PRK11728
351627002934	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
351627002935	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
351627002936	active site
351627002937	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
351627002938	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
351627002939	Competence protein; Region: Competence; pfam03772
351627002940	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
351627002941	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
351627002942	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
351627002943	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
351627002944	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
351627002945	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
351627002946	NAD binding site [chemical binding]; other site
351627002947	dimer interface [polypeptide binding]; other site
351627002948	substrate binding site [chemical binding]; other site
351627002949	tetramer (dimer of dimers) interface [polypeptide binding]; other site
351627002950	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
351627002951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627002952	dimer interface [polypeptide binding]; other site
351627002953	conserved gate region; other site
351627002954	putative PBP binding loops; other site
351627002955	ABC-ATPase subunit interface; other site
351627002956	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
351627002957	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
351627002958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627002959	dimer interface [polypeptide binding]; other site
351627002960	conserved gate region; other site
351627002961	putative PBP binding loops; other site
351627002962	ABC-ATPase subunit interface; other site
351627002963	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
351627002964	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351627002965	Walker A/P-loop; other site
351627002966	ATP binding site [chemical binding]; other site
351627002967	Q-loop/lid; other site
351627002968	ABC transporter signature motif; other site
351627002969	Walker B; other site
351627002970	D-loop; other site
351627002971	H-loop/switch region; other site
351627002972	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
351627002973	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
351627002974	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
351627002975	Walker A/P-loop; other site
351627002976	ATP binding site [chemical binding]; other site
351627002977	Q-loop/lid; other site
351627002978	ABC transporter signature motif; other site
351627002979	Walker B; other site
351627002980	D-loop; other site
351627002981	H-loop/switch region; other site
351627002982	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
351627002983	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
351627002984	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
351627002985	peptide binding site [polypeptide binding]; other site
351627002986	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
351627002987	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
351627002988	metal binding site [ion binding]; metal-binding site
351627002989	dimer interface [polypeptide binding]; other site
351627002990	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
351627002991	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351627002992	DNA-binding site [nucleotide binding]; DNA binding site
351627002993	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351627002994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627002995	homodimer interface [polypeptide binding]; other site
351627002996	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
351627002997	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
351627002998	active site
351627002999	multimer interface [polypeptide binding]; other site
351627003000	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
351627003001	imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855
351627003002	predicted active site [active]
351627003003	catalytic triad [active]
351627003004	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
351627003005	Uncharacterized conserved protein [Function unknown]; Region: COG0062
351627003006	putative carbohydrate kinase; Provisional; Region: PRK10565
351627003007	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
351627003008	putative substrate binding site [chemical binding]; other site
351627003009	putative ATP binding site [chemical binding]; other site
351627003010	alanine racemase; Reviewed; Region: alr; PRK00053
351627003011	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
351627003012	active site
351627003013	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351627003014	dimer interface [polypeptide binding]; other site
351627003015	substrate binding site [chemical binding]; other site
351627003016	catalytic residues [active]
351627003017	PemK-like protein; Region: PemK; pfam02452
351627003018	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
351627003019	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
351627003020	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
351627003021	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351627003022	catalytic residues [active]
351627003023	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
351627003024	lipoyl attachment site [posttranslational modification]; other site
351627003025	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
351627003026	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
351627003027	intersubunit interface [polypeptide binding]; other site
351627003028	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
351627003029	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
351627003030	ABC-ATPase subunit  interface; other site
351627003031	dimer interface [polypeptide binding]; other site
351627003032	putative PBP binding regions; other site
351627003033	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
351627003034	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
351627003035	Walker A/P-loop; other site
351627003036	ATP binding site [chemical binding]; other site
351627003037	Q-loop/lid; other site
351627003038	ABC transporter signature motif; other site
351627003039	Walker B; other site
351627003040	D-loop; other site
351627003041	H-loop/switch region; other site
351627003042	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
351627003043	Bacterial SH3 domain; Region: SH3_3; pfam08239
351627003044	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
351627003045	NlpC/P60 family; Region: NLPC_P60; pfam00877
351627003046	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
351627003047	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
351627003048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351627003049	active site
351627003050	motif I; other site
351627003051	motif II; other site
351627003052	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
351627003053	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
351627003054	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
351627003055	shikimate binding site; other site
351627003056	NAD(P) binding site [chemical binding]; other site
351627003057	Predicted membrane protein [Function unknown]; Region: COG2246
351627003058	GtrA-like protein; Region: GtrA; pfam04138
351627003059	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
351627003060	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
351627003061	Ligand binding site; other site
351627003062	Putative Catalytic site; other site
351627003063	DXD motif; other site
351627003064	Response regulator receiver domain; Region: Response_reg; pfam00072
351627003065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627003066	active site
351627003067	phosphorylation site [posttranslational modification]
351627003068	intermolecular recognition site; other site
351627003069	dimerization interface [polypeptide binding]; other site
351627003070	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
351627003071	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
351627003072	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
351627003073	Walker A motif; other site
351627003074	ATP binding site [chemical binding]; other site
351627003075	Walker B motif; other site
351627003076	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
351627003077	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627003078	Walker A motif; other site
351627003079	ATP binding site [chemical binding]; other site
351627003080	Walker B motif; other site
351627003081	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
351627003082	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351627003083	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351627003084	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
351627003085	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
351627003086	Late competence development protein ComFB; Region: ComFB; pfam10719
351627003087	Competence protein A; Region: Competence_A; pfam11104
351627003088	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
351627003089	Integrase core domain; Region: rve; pfam00665
351627003090	endoglucanase; Region: PLN02420
351627003091	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
351627003092	Cellulose binding domain; Region: CBM_3; smart01067
351627003093	Cellulose binding domain; Region: CBM_3; pfam00942
351627003094	Cellulose binding domain; Region: CBM_3; pfam00942
351627003095	Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011
351627003096	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
351627003097	Cellulose binding domain; Region: CBM_3; pfam00942
351627003098	Cellulose binding domain; Region: CBM_3; pfam00942
351627003099	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
351627003100	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
351627003101	Cellulose binding domain; Region: CBM_3; pfam00942
351627003102	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
351627003103	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
351627003104	endoglucanase; Region: PLN02420
351627003105	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
351627003106	Cellulose binding domain; Region: CBM_3; smart01067
351627003107	Cellulose binding domain; Region: CBM_3; pfam00942
351627003108	Cellulose binding domain; Region: CBM_3; pfam00942
351627003109	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
351627003110	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
351627003111	Predicted integral membrane protein [Function unknown]; Region: COG5542
351627003112	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
351627003113	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
351627003114	Cellulose binding domain; Region: CBM_3; pfam00942
351627003115	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627003116	MULE transposase domain; Region: MULE; pfam10551
351627003117	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
351627003118	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
351627003119	DNA binding site [nucleotide binding]
351627003120	active site
351627003121	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
351627003122	beta-galactosidase; Region: BGL; TIGR03356
351627003123	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
351627003124	catalytic domain interface [polypeptide binding]; other site
351627003125	putative homodimer interface [polypeptide binding]; other site
351627003126	Protein of unknown function, DUF608; Region: DUF608; pfam04685
351627003127	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
351627003128	N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754
351627003129	catalytic domain interface [polypeptide binding]; other site
351627003130	homodimer interface [polypeptide binding]; other site
351627003131	putative active site [active]
351627003132	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627003133	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
351627003134	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
351627003135	Bacterial sugar transferase; Region: Bac_transf; pfam02397
351627003136	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
351627003137	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
351627003138	SmpB-tmRNA interface; other site
351627003139	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
351627003140	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351627003141	active site
351627003142	catalytic tetrad [active]
351627003143	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351627003144	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
351627003145	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
351627003146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627003147	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351627003148	putative substrate translocation pore; other site
351627003149	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351627003150	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627003151	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627003152	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
351627003153	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
351627003154	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
351627003155	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
351627003156	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627003157	dimerization interface [polypeptide binding]; other site
351627003158	Histidine kinase; Region: His_kinase; pfam06580
351627003159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627003160	Mg2+ binding site [ion binding]; other site
351627003161	G-X-G motif; other site
351627003162	Response regulator receiver domain; Region: Response_reg; pfam00072
351627003163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627003164	active site
351627003165	phosphorylation site [posttranslational modification]
351627003166	intermolecular recognition site; other site
351627003167	dimerization interface [polypeptide binding]; other site
351627003168	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
351627003169	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627003170	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627003171	dimer interface [polypeptide binding]; other site
351627003172	conserved gate region; other site
351627003173	putative PBP binding loops; other site
351627003174	ABC-ATPase subunit interface; other site
351627003175	Integrase core domain; Region: rve; pfam00665
351627003176	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
351627003177	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
351627003178	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
351627003179	Integrase core domain; Region: rve; pfam00665
351627003180	Transposase domain (DUF772); Region: DUF772; pfam05598
351627003181	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627003182	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627003183	potential frameshift: common BLAST hit: gi|312128395|ref|YP_003993269.1| SNF2-like protein
351627003184	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
351627003185	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
351627003186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351627003187	active site
351627003188	catalytic tetrad [active]
351627003189	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351627003190	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627003191	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627003192	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
351627003193	Walker A/P-loop; other site
351627003194	ATP binding site [chemical binding]; other site
351627003195	Q-loop/lid; other site
351627003196	ABC transporter signature motif; other site
351627003197	Walker B; other site
351627003198	D-loop; other site
351627003199	H-loop/switch region; other site
351627003200	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
351627003201	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
351627003202	Melibiase; Region: Melibiase; pfam02065
351627003203	Predicted acetyltransferase [General function prediction only]; Region: COG3393
351627003204	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
351627003205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
351627003206	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
351627003207	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
351627003208	G1 box; other site
351627003209	GTP/Mg2+ binding site [chemical binding]; other site
351627003210	Switch I region; other site
351627003211	G2 box; other site
351627003212	Switch II region; other site
351627003213	G3 box; other site
351627003214	G4 box; other site
351627003215	G5 box; other site
351627003216	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
351627003217	Aspartase; Region: Aspartase; cd01357
351627003218	active sites [active]
351627003219	tetramer interface [polypeptide binding]; other site
351627003220	Radical SAM superfamily; Region: Radical_SAM; pfam04055
351627003221	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
351627003222	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
351627003223	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
351627003224	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627003225	Walker A/P-loop; other site
351627003226	ATP binding site [chemical binding]; other site
351627003227	Q-loop/lid; other site
351627003228	ABC transporter signature motif; other site
351627003229	Walker B; other site
351627003230	D-loop; other site
351627003231	H-loop/switch region; other site
351627003232	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
351627003233	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
351627003234	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
351627003235	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351627003236	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627003237	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627003238	Uncharacterized conserved protein [Function unknown]; Region: COG1633
351627003239	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
351627003240	diiron binding motif [ion binding]; other site
351627003241	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
351627003242	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351627003243	Coenzyme A binding pocket [chemical binding]; other site
351627003244	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
351627003245	active site
351627003246	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
351627003247	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
351627003248	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351627003249	NAD(P) binding site [chemical binding]; other site
351627003250	active site
351627003251	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
351627003252	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
351627003253	PYR/PP interface [polypeptide binding]; other site
351627003254	dimer interface [polypeptide binding]; other site
351627003255	TPP binding site [chemical binding]; other site
351627003256	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
351627003257	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
351627003258	TPP-binding site [chemical binding]; other site
351627003259	dimer interface [polypeptide binding]; other site
351627003260	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
351627003261	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
351627003262	putative valine binding site [chemical binding]; other site
351627003263	dimer interface [polypeptide binding]; other site
351627003264	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
351627003265	ketol-acid reductoisomerase; Provisional; Region: PRK05479
351627003266	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
351627003267	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
351627003268	2-isopropylmalate synthase; Validated; Region: PRK00915
351627003269	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
351627003270	active site
351627003271	catalytic residues [active]
351627003272	metal binding site [ion binding]; metal-binding site
351627003273	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
351627003274	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
351627003275	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
351627003276	active site
351627003277	catalytic residues [active]
351627003278	metal binding site [ion binding]; metal-binding site
351627003279	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
351627003280	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
351627003281	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351627003282	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
351627003283	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
351627003284	Penicillinase repressor; Region: Pencillinase_R; pfam03965
351627003285	Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945
351627003286	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
351627003287	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
351627003288	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351627003289	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
351627003290	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627003291	MULE transposase domain; Region: MULE; pfam10551
351627003292	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
351627003293	FAD binding domain; Region: FAD_binding_4; pfam01565
351627003294	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
351627003295	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
351627003296	shikimate kinase; Reviewed; Region: aroK; PRK00131
351627003297	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
351627003298	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
351627003299	phosphate binding site [ion binding]; other site
351627003300	putative substrate binding pocket [chemical binding]; other site
351627003301	dimer interface [polypeptide binding]; other site
351627003302	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
351627003303	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
351627003304	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
351627003305	regulatory protein interface [polypeptide binding]; other site
351627003306	active site
351627003307	regulatory phosphorylation site [posttranslational modification]; other site
351627003308	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
351627003309	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
351627003310	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
351627003311	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
351627003312	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
351627003313	FAD binding site [chemical binding]; other site
351627003314	Part of AAA domain; Region: AAA_19; pfam13245
351627003315	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
351627003316	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
351627003317	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
351627003318	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627003319	FeS/SAM binding site; other site
351627003320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627003321	putative substrate translocation pore; other site
351627003322	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351627003323	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627003324	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351627003325	DNA binding site [nucleotide binding]
351627003326	domain linker motif; other site
351627003327	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
351627003328	dimerization interface [polypeptide binding]; other site
351627003329	ligand binding site [chemical binding]; other site
351627003330	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
351627003331	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
351627003332	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
351627003333	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
351627003334	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
351627003335	AP (apurinic/apyrimidinic) site pocket; other site
351627003336	DNA interaction; other site
351627003337	Metal-binding active site; metal-binding site
351627003338	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
351627003339	RHS Repeat; Region: RHS_repeat; pfam05593
351627003340	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
351627003341	RHS Repeat; Region: RHS_repeat; pfam05593
351627003342	RHS Repeat; Region: RHS_repeat; cl11982
351627003343	RHS Repeat; Region: RHS_repeat; pfam05593
351627003344	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
351627003345	RHS Repeat; Region: RHS_repeat; pfam05593
351627003346	RHS Repeat; Region: RHS_repeat; cl11982
351627003347	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
351627003348	RHS Repeat; Region: RHS_repeat; pfam05593
351627003349	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
351627003350	RHS Repeat; Region: RHS_repeat; pfam05593
351627003351	RHS Repeat; Region: RHS_repeat; pfam05593
351627003352	RHS Repeat; Region: RHS_repeat; pfam05593
351627003353	RHS Repeat; Region: RHS_repeat; pfam05593
351627003354	RHS Repeat; Region: RHS_repeat; pfam05593
351627003355	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
351627003356	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
351627003357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627003358	MULE transposase domain; Region: MULE; pfam10551
351627003359	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351627003360	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627003361	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627003362	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627003363	MULE transposase domain; Region: MULE; pfam10551
351627003364	hypothetical protein; Provisional; Region: PRK03881
351627003365	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
351627003366	AMMECR1; Region: AMMECR1; pfam01871
351627003367	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
351627003368	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627003369	FeS/SAM binding site; other site
351627003370	Uncharacterized conserved protein [Function unknown]; Region: COG1624
351627003371	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
351627003372	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
351627003373	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
351627003374	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
351627003375	GIY-YIG motif/motif A; other site
351627003376	active site
351627003377	catalytic site [active]
351627003378	putative DNA binding site [nucleotide binding]; other site
351627003379	metal binding site [ion binding]; metal-binding site
351627003380	UvrB/uvrC motif; Region: UVR; pfam02151
351627003381	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
351627003382	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
351627003383	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
351627003384	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
351627003385	Hpr binding site; other site
351627003386	active site
351627003387	homohexamer subunit interaction site [polypeptide binding]; other site
351627003388	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
351627003389	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
351627003390	dimer interface [polypeptide binding]; other site
351627003391	active site
351627003392	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
351627003393	dimer interface [polypeptide binding]; other site
351627003394	active site
351627003395	putative hydrolase; Validated; Region: PRK09248
351627003396	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
351627003397	active site
351627003398	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
351627003399	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
351627003400	intersubunit interface [polypeptide binding]; other site
351627003401	active site
351627003402	zinc binding site [ion binding]; other site
351627003403	Na+ binding site [ion binding]; other site
351627003404	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
351627003405	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
351627003406	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627003407	FeS/SAM binding site; other site
351627003408	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
351627003409	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
351627003410	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
351627003411	trimer interface [polypeptide binding]; other site
351627003412	putative metal binding site [ion binding]; other site
351627003413	protein-export membrane protein SecD; Region: secD; TIGR01129
351627003414	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
351627003415	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
351627003416	Protein export membrane protein; Region: SecD_SecF; pfam02355
351627003417	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
351627003418	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
351627003419	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
351627003420	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
351627003421	Predicted amidohydrolase [General function prediction only]; Region: COG0388
351627003422	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
351627003423	active site
351627003424	catalytic triad [active]
351627003425	dimer interface [polypeptide binding]; other site
351627003426	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
351627003427	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
351627003428	hinge; other site
351627003429	active site
351627003430	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
351627003431	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
351627003432	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627003433	active site
351627003434	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
351627003435	catalytic motif [active]
351627003436	Zn binding site [ion binding]; other site
351627003437	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
351627003438	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
351627003439	Substrate binding site; other site
351627003440	Mg++ binding site; other site
351627003441	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
351627003442	active site
351627003443	substrate binding site [chemical binding]; other site
351627003444	CoA binding site [chemical binding]; other site
351627003445	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
351627003446	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
351627003447	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627003448	active site
351627003449	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
351627003450	putative active site [active]
351627003451	catalytic residue [active]
351627003452	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
351627003453	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
351627003454	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351627003455	ATP binding site [chemical binding]; other site
351627003456	putative Mg++ binding site [ion binding]; other site
351627003457	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351627003458	nucleotide binding region [chemical binding]; other site
351627003459	ATP-binding site [chemical binding]; other site
351627003460	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
351627003461	SurA N-terminal domain; Region: SurA_N_3; cl07813
351627003462	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
351627003463	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
351627003464	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
351627003465	Ligand Binding Site [chemical binding]; other site
351627003466	TilS substrate C-terminal domain; Region: TilS_C; smart00977
351627003467	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627003468	active site
351627003469	FtsH Extracellular; Region: FtsH_ext; pfam06480
351627003470	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
351627003471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627003472	Walker A motif; other site
351627003473	ATP binding site [chemical binding]; other site
351627003474	Walker B motif; other site
351627003475	arginine finger; other site
351627003476	Peptidase family M41; Region: Peptidase_M41; pfam01434
351627003477	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
351627003478	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
351627003479	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
351627003480	Stage III sporulation protein D; Region: SpoIIID; pfam12116
351627003481	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
351627003482	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
351627003483	homodimer interface [polypeptide binding]; other site
351627003484	metal binding site [ion binding]; metal-binding site
351627003485	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
351627003486	homodimer interface [polypeptide binding]; other site
351627003487	active site
351627003488	putative chemical substrate binding site [chemical binding]; other site
351627003489	metal binding site [ion binding]; metal-binding site
351627003490	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
351627003491	IHF dimer interface [polypeptide binding]; other site
351627003492	IHF - DNA interface [nucleotide binding]; other site
351627003493	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351627003494	RNA binding surface [nucleotide binding]; other site
351627003495	YabP family; Region: YabP; cl06766
351627003496	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
351627003497	Septum formation initiator; Region: DivIC; cl17659
351627003498	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
351627003499	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
351627003500	RNA binding site [nucleotide binding]; other site
351627003501	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
351627003502	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
351627003503	CoA binding domain; Region: CoA_binding; smart00881
351627003504	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
351627003505	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
351627003506	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627003507	catalytic residue [active]
351627003508	MgtE intracellular N domain; Region: MgtE_N; pfam03448
351627003509	FOG: CBS domain [General function prediction only]; Region: COG0517
351627003510	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
351627003511	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
351627003512	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
351627003513	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
351627003514	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
351627003515	Potassium binding sites [ion binding]; other site
351627003516	Cesium cation binding sites [ion binding]; other site
351627003517	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
351627003518	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
351627003519	substrate-cofactor binding pocket; other site
351627003520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627003521	catalytic residue [active]
351627003522	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
351627003523	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
351627003524	NAD(P) binding site [chemical binding]; other site
351627003525	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627003526	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351627003527	DNA binding site [nucleotide binding]
351627003528	domain linker motif; other site
351627003529	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
351627003530	putative dimerization interface [polypeptide binding]; other site
351627003531	putative ligand binding site [chemical binding]; other site
351627003532	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351627003533	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351627003534	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
351627003535	Predicted methyltransferases [General function prediction only]; Region: COG1568
351627003536	Uncharacterized conserved protein [Function unknown]; Region: COG0585
351627003537	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
351627003538	active site
351627003539	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
351627003540	putative acetyltransferase; Provisional; Region: PRK03624
351627003541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351627003542	Coenzyme A binding pocket [chemical binding]; other site
351627003543	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
351627003544	putative active site [active]
351627003545	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627003546	active site
351627003547	NTP binding site [chemical binding]; other site
351627003548	metal binding triad [ion binding]; metal-binding site
351627003549	antibiotic binding site [chemical binding]; other site
351627003550	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
351627003551	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
351627003552	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
351627003553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627003554	Walker A motif; other site
351627003555	ATP binding site [chemical binding]; other site
351627003556	Walker B motif; other site
351627003557	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
351627003558	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
351627003559	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
351627003560	ABC-ATPase subunit  interface; other site
351627003561	dimer interface [polypeptide binding]; other site
351627003562	putative PBP binding regions; other site
351627003563	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
351627003564	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
351627003565	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
351627003566	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
351627003567	intersubunit interface [polypeptide binding]; other site
351627003568	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
351627003569	metal binding site 2 [ion binding]; metal-binding site
351627003570	putative DNA binding helix; other site
351627003571	metal binding site 1 [ion binding]; metal-binding site
351627003572	dimer interface [polypeptide binding]; other site
351627003573	structural Zn2+ binding site [ion binding]; other site
351627003574	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627003575	dimerization interface [polypeptide binding]; other site
351627003576	putative DNA binding site [nucleotide binding]; other site
351627003577	putative Zn2+ binding site [ion binding]; other site
351627003578	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627003579	Radical SAM superfamily; Region: Radical_SAM; pfam04055
351627003580	FeS/SAM binding site; other site
351627003581	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
351627003582	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
351627003583	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
351627003584	hypothetical protein; Reviewed; Region: PRK09588
351627003585	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
351627003586	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
351627003587	DNA binding site [nucleotide binding]
351627003588	DNA protecting protein DprA; Region: dprA; TIGR00732
351627003589	DNA topoisomerase I; Validated; Region: PRK05582
351627003590	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
351627003591	active site
351627003592	interdomain interaction site; other site
351627003593	putative metal-binding site [ion binding]; other site
351627003594	nucleotide binding site [chemical binding]; other site
351627003595	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
351627003596	domain I; other site
351627003597	DNA binding groove [nucleotide binding]
351627003598	phosphate binding site [ion binding]; other site
351627003599	domain II; other site
351627003600	domain III; other site
351627003601	nucleotide binding site [chemical binding]; other site
351627003602	catalytic site [active]
351627003603	domain IV; other site
351627003604	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
351627003605	RNA polymerase subunit 9; Region: RPOL9; smart00661
351627003606	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
351627003607	Glucose inhibited division protein A; Region: GIDA; pfam01134
351627003608	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
351627003609	active site
351627003610	HslU subunit interaction site [polypeptide binding]; other site
351627003611	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
351627003612	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627003613	Walker A motif; other site
351627003614	ATP binding site [chemical binding]; other site
351627003615	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
351627003616	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
351627003617	transcriptional repressor CodY; Validated; Region: PRK04158
351627003618	CodY GAF-like domain; Region: CodY; pfam06018
351627003619	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
351627003620	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
351627003621	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
351627003622	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
351627003623	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
351627003624	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
351627003625	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
351627003626	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
351627003627	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
351627003628	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
351627003629	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
351627003630	FliG C-terminal domain; Region: FliG_C; pfam01706
351627003631	Flagellar assembly protein FliH; Region: FliH; pfam02108
351627003632	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
351627003633	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
351627003634	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
351627003635	Walker A motif/ATP binding site; other site
351627003636	Walker B motif; other site
351627003637	Uncharacterized conserved protein [Function unknown]; Region: COG3334
351627003638	MgtE intracellular N domain; Region: MgtE_N; cl15244
351627003639	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
351627003640	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
351627003641	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
351627003642	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
351627003643	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
351627003644	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
351627003645	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
351627003646	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
351627003647	Flagellar protein (FlbD); Region: FlbD; pfam06289
351627003648	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
351627003649	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
351627003650	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
351627003651	flagellar motor switch protein; Validated; Region: PRK08119
351627003652	CheC-like family; Region: CheC; pfam04509
351627003653	CheC-like family; Region: CheC; pfam04509
351627003654	flagellar motor switch protein FliN; Region: fliN; TIGR02480
351627003655	Response regulator receiver domain; Region: Response_reg; pfam00072
351627003656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627003657	active site
351627003658	phosphorylation site [posttranslational modification]
351627003659	intermolecular recognition site; other site
351627003660	dimerization interface [polypeptide binding]; other site
351627003661	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
351627003662	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
351627003663	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
351627003664	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
351627003665	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
351627003666	Predicted membrane protein [Function unknown]; Region: COG2259
351627003667	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
351627003668	Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419
351627003669	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
351627003670	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
351627003671	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
351627003672	P-loop; other site
351627003673	Flagellar protein YcgR; Region: YcgR_2; pfam12945
351627003674	PilZ domain; Region: PilZ; pfam07238
351627003675	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
351627003676	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
351627003677	putative binding surface; other site
351627003678	active site
351627003679	P2 response regulator binding domain; Region: P2; pfam07194
351627003680	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
351627003681	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627003682	ATP binding site [chemical binding]; other site
351627003683	Mg2+ binding site [ion binding]; other site
351627003684	G-X-G motif; other site
351627003685	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
351627003686	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
351627003687	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
351627003688	CheC-like family; Region: CheC; pfam04509
351627003689	Chemotaxis phosphatase CheX; Region: CheX; cl15816
351627003690	CheC-like family; Region: CheC; pfam04509
351627003691	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488
351627003692	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
351627003693	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627003694	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
351627003695	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627003696	DNA binding residues [nucleotide binding]
351627003697	Protein of unknown function (DUF342); Region: DUF342; pfam03961
351627003698	YceG-like family; Region: YceG; pfam02618
351627003699	Cupin domain; Region: Cupin_2; pfam07883
351627003700	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627003701	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627003702	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627003703	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
351627003704	oligomerisation interface [polypeptide binding]; other site
351627003705	mobile loop; other site
351627003706	roof hairpin; other site
351627003707	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
351627003708	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
351627003709	ring oligomerisation interface [polypeptide binding]; other site
351627003710	ATP/Mg binding site [chemical binding]; other site
351627003711	stacking interactions; other site
351627003712	hinge regions; other site
351627003713	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351627003714	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
351627003715	active site
351627003716	motif I; other site
351627003717	motif II; other site
351627003718	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351627003719	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
351627003720	Uncharacterized conserved protein [Function unknown]; Region: COG2006
351627003721	Domain of unknown function (DUF362); Region: DUF362; pfam04015
351627003722	4Fe-4S binding domain; Region: Fer4_6; pfam12837
351627003723	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
351627003724	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
351627003725	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
351627003726	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
351627003727	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
351627003728	EDD domain protein, DegV family; Region: DegV; TIGR00762
351627003729	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
351627003730	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
351627003731	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
351627003732	B12 binding site [chemical binding]; other site
351627003733	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627003734	FeS/SAM binding site; other site
351627003735	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
351627003736	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
351627003737	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
351627003738	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
351627003739	homodimer interface [polypeptide binding]; other site
351627003740	oligonucleotide binding site [chemical binding]; other site
351627003741	elongation factor P; Validated; Region: PRK00529
351627003742	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
351627003743	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
351627003744	RNA binding site [nucleotide binding]; other site
351627003745	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
351627003746	RNA binding site [nucleotide binding]; other site
351627003747	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
351627003748	homodimer interface [polypeptide binding]; other site
351627003749	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627003750	catalytic residue [active]
351627003751	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
351627003752	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
351627003753	ligand binding site [chemical binding]; other site
351627003754	NAD binding site [chemical binding]; other site
351627003755	dimerization interface [polypeptide binding]; other site
351627003756	catalytic site [active]
351627003757	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
351627003758	putative L-serine binding site [chemical binding]; other site
351627003759	Uncharacterized conserved protein [Function unknown]; Region: COG4198
351627003760	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
351627003761	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
351627003762	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351627003763	motif II; other site
351627003764	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351627003765	Integrase core domain; Region: rve; pfam00665
351627003766	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
351627003767	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
351627003768	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
351627003769	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
351627003770	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
351627003771	metal ion-dependent adhesion site (MIDAS); other site
351627003772	Right handed beta helix region; Region: Beta_helix; pfam13229
351627003773	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
351627003774	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
351627003775	putative substrate binding site [chemical binding]; other site
351627003776	putative ATP binding site [chemical binding]; other site
351627003777	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
351627003778	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
351627003779	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
351627003780	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
351627003781	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
351627003782	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
351627003783	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
351627003784	DNA binding residues [nucleotide binding]
351627003785	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
351627003786	catalytic residues [active]
351627003787	catalytic nucleophile [active]
351627003788	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
351627003789	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627003790	Zn2+ binding site [ion binding]; other site
351627003791	Mg2+ binding site [ion binding]; other site
351627003792	ribonuclease R; Region: RNase_R; TIGR02063
351627003793	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
351627003794	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
351627003795	RNB domain; Region: RNB; pfam00773
351627003796	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
351627003797	RNA binding site [nucleotide binding]; other site
351627003798	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
351627003799	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627003800	Walker A motif; other site
351627003801	ATP binding site [chemical binding]; other site
351627003802	Walker B motif; other site
351627003803	arginine finger; other site
351627003804	Domain of unknown function (DUF362); Region: DUF362; pfam04015
351627003805	Uncharacterized conserved protein [Function unknown]; Region: COG2006
351627003806	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
351627003807	30S subunit binding site; other site
351627003808	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
351627003809	DEAD/DEAH box helicase; Region: DEAD; pfam00270
351627003810	ATP binding site [chemical binding]; other site
351627003811	putative Mg++ binding site [ion binding]; other site
351627003812	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
351627003813	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351627003814	nucleotide binding region [chemical binding]; other site
351627003815	ATP-binding site [chemical binding]; other site
351627003816	peptide chain release factor 2; Provisional; Region: PRK05589
351627003817	This domain is found in peptide chain release factors; Region: PCRF; smart00937
351627003818	RF-1 domain; Region: RF-1; pfam00472
351627003819	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
351627003820	Response regulator receiver domain; Region: Response_reg; pfam00072
351627003821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627003822	active site
351627003823	phosphorylation site [posttranslational modification]
351627003824	intermolecular recognition site; other site
351627003825	dimerization interface [polypeptide binding]; other site
351627003826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351627003827	dimer interface [polypeptide binding]; other site
351627003828	phosphorylation site [posttranslational modification]
351627003829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627003830	ATP binding site [chemical binding]; other site
351627003831	G-X-G motif; other site
351627003832	Response regulator receiver domain; Region: Response_reg; pfam00072
351627003833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627003834	active site
351627003835	phosphorylation site [posttranslational modification]
351627003836	intermolecular recognition site; other site
351627003837	dimerization interface [polypeptide binding]; other site
351627003838	HDOD domain; Region: HDOD; pfam08668
351627003839	Response regulator receiver domain; Region: Response_reg; pfam00072
351627003840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627003841	active site
351627003842	phosphorylation site [posttranslational modification]
351627003843	intermolecular recognition site; other site
351627003844	dimerization interface [polypeptide binding]; other site
351627003845	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
351627003846	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
351627003847	substrate binding site [chemical binding]; other site
351627003848	ligand binding site [chemical binding]; other site
351627003849	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
351627003850	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
351627003851	substrate binding site [chemical binding]; other site
351627003852	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
351627003853	tartrate dehydrogenase; Region: TTC; TIGR02089
351627003854	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
351627003855	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351627003856	active site
351627003857	catalytic tetrad [active]
351627003858	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351627003859	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
351627003860	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
351627003861	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
351627003862	dimer interface [polypeptide binding]; other site
351627003863	ssDNA binding site [nucleotide binding]; other site
351627003864	tetramer (dimer of dimers) interface [polypeptide binding]; other site
351627003865	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
351627003866	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627003867	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351627003868	DNA binding site [nucleotide binding]
351627003869	domain linker motif; other site
351627003870	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
351627003871	dimerization interface [polypeptide binding]; other site
351627003872	ligand binding site [chemical binding]; other site
351627003873	L-fucose isomerase; Provisional; Region: fucI; PRK10991
351627003874	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
351627003875	hexamer (dimer of trimers) interface [polypeptide binding]; other site
351627003876	trimer interface [polypeptide binding]; other site
351627003877	substrate binding site [chemical binding]; other site
351627003878	Mn binding site [ion binding]; other site
351627003879	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
351627003880	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
351627003881	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
351627003882	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
351627003883	23S rRNA interface [nucleotide binding]; other site
351627003884	L3 interface [polypeptide binding]; other site
351627003885	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
351627003886	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
351627003887	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
351627003888	Nitrogen regulatory protein P-II; Region: P-II; smart00938
351627003889	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627003890	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
351627003891	DNA repair protein RadA; Provisional; Region: PRK11823
351627003892	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
351627003893	Walker A motif/ATP binding site; other site
351627003894	ATP binding site [chemical binding]; other site
351627003895	Walker B motif; other site
351627003896	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
351627003897	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
351627003898	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
351627003899	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
351627003900	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
351627003901	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
351627003902	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
351627003903	Uncharacterized conserved protein [Function unknown]; Region: COG1284
351627003904	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
351627003905	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
351627003906	transketolase; Reviewed; Region: PRK05899
351627003907	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
351627003908	TPP-binding site [chemical binding]; other site
351627003909	dimer interface [polypeptide binding]; other site
351627003910	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
351627003911	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
351627003912	PYR/PP interface [polypeptide binding]; other site
351627003913	dimer interface [polypeptide binding]; other site
351627003914	TPP binding site [chemical binding]; other site
351627003915	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
351627003916	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351627003917	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
351627003918	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627003919	putative alpha-glucosidase; Provisional; Region: PRK10658
351627003920	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
351627003921	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
351627003922	active site
351627003923	homotrimer interface [polypeptide binding]; other site
351627003924	catalytic site [active]
351627003925	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
351627003926	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627003927	dimerization interface [polypeptide binding]; other site
351627003928	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
351627003929	Histidine kinase; Region: His_kinase; pfam06580
351627003930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627003931	ATP binding site [chemical binding]; other site
351627003932	Mg2+ binding site [ion binding]; other site
351627003933	G-X-G motif; other site
351627003934	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
351627003935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627003936	active site
351627003937	phosphorylation site [posttranslational modification]
351627003938	intermolecular recognition site; other site
351627003939	dimerization interface [polypeptide binding]; other site
351627003940	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627003941	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627003942	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627003943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627003944	dimer interface [polypeptide binding]; other site
351627003945	conserved gate region; other site
351627003946	ABC-ATPase subunit interface; other site
351627003947	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627003948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627003949	dimer interface [polypeptide binding]; other site
351627003950	ABC-ATPase subunit interface; other site
351627003951	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627003952	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627003953	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
351627003954	MgtC family; Region: MgtC; pfam02308
351627003955	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
351627003956	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
351627003957	homodimer interface [polypeptide binding]; other site
351627003958	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627003959	catalytic residue [active]
351627003960	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
351627003961	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
351627003962	active site
351627003963	metal binding site [ion binding]; metal-binding site
351627003964	dimerization interface [polypeptide binding]; other site
351627003965	Protein of unknown function (DUF1646); Region: DUF1646; pfam07854
351627003966	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
351627003967	DNA replication protein DnaC; Validated; Region: PRK06835
351627003968	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627003969	Walker A motif; other site
351627003970	ATP binding site [chemical binding]; other site
351627003971	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
351627003972	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
351627003973	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
351627003974	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
351627003975	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
351627003976	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
351627003977	YacP-like NYN domain; Region: NYN_YacP; pfam05991
351627003978	RNA polymerase factor sigma-70; Validated; Region: PRK08295
351627003979	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627003980	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
351627003981	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
351627003982	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
351627003983	active site
351627003984	substrate binding site [chemical binding]; other site
351627003985	metal binding site [ion binding]; metal-binding site
351627003986	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
351627003987	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
351627003988	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
351627003989	glutamate racemase; Provisional; Region: PRK00865
351627003990	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
351627003991	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
351627003992	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
351627003993	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
351627003994	active site
351627003995	HIGH motif; other site
351627003996	KMSK motif region; other site
351627003997	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
351627003998	tRNA binding surface [nucleotide binding]; other site
351627003999	anticodon binding site; other site
351627004000	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
351627004001	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
351627004002	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
351627004003	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
351627004004	active site
351627004005	FMN binding site [chemical binding]; other site
351627004006	substrate binding site [chemical binding]; other site
351627004007	3Fe-4S cluster binding site [ion binding]; other site
351627004008	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
351627004009	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
351627004010	Int/Topo IB signature motif; other site
351627004011	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
351627004012	DNA-binding interface [nucleotide binding]; DNA binding site
351627004013	PrgI family protein; Region: PrgI; pfam12666
351627004014	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
351627004015	AAA-like domain; Region: AAA_10; pfam12846
351627004016	Domain of unknown function DUF87; Region: DUF87; pfam01935
351627004017	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627004018	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
351627004019	IHF dimer interface [polypeptide binding]; other site
351627004020	IHF - DNA interface [nucleotide binding]; other site
351627004021	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
351627004022	plasmid segregation protein ParM; Provisional; Region: PRK13917
351627004023	Mg binding site [ion binding]; other site
351627004024	nucleotide binding site [chemical binding]; other site
351627004025	putative protofilament interface [polypeptide binding]; other site
351627004026	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
351627004027	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627004028	Walker A motif; other site
351627004029	ATP binding site [chemical binding]; other site
351627004030	Walker B motif; other site
351627004031	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
351627004032	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
351627004033	RNA binding site [nucleotide binding]; other site
351627004034	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
351627004035	RNA binding site [nucleotide binding]; other site
351627004036	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
351627004037	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627004038	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
351627004039	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
351627004040	toxin interface [polypeptide binding]; other site
351627004041	Zn binding site [ion binding]; other site
351627004042	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351627004043	non-specific DNA binding site [nucleotide binding]; other site
351627004044	salt bridge; other site
351627004045	sequence-specific DNA binding site [nucleotide binding]; other site
351627004046	Domain of unknown function (DUF955); Region: DUF955; cl01076
351627004047	Large family of predicted nucleotide-binding domains; Region: PINc; smart00670
351627004048	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
351627004049	Helix-turn-helix domain; Region: HTH_36; pfam13730
351627004050	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351627004051	non-specific DNA binding site [nucleotide binding]; other site
351627004052	salt bridge; other site
351627004053	sequence-specific DNA binding site [nucleotide binding]; other site
351627004054	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627004055	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351627004056	Fic/DOC family; Region: Fic; cl00960
351627004057	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
351627004058	response regulator PleD; Reviewed; Region: pleD; PRK09581
351627004059	AAA domain; Region: AAA_31; pfam13614
351627004060	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351627004061	P-loop; other site
351627004062	Magnesium ion binding site [ion binding]; other site
351627004063	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
351627004064	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
351627004065	AAA domain; Region: AAA_31; pfam13614
351627004066	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
351627004067	AAA domain; Region: AAA_31; pfam13614
351627004068	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351627004069	P-loop; other site
351627004070	Magnesium ion binding site [ion binding]; other site
351627004071	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
351627004072	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627004073	Walker A motif; other site
351627004074	ATP binding site [chemical binding]; other site
351627004075	Walker B motif; other site
351627004076	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
351627004077	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351627004078	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
351627004079	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
351627004080	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
351627004081	dimer interface [polypeptide binding]; other site
351627004082	ssDNA binding site [nucleotide binding]; other site
351627004083	tetramer (dimer of dimers) interface [polypeptide binding]; other site
351627004084	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627004085	Zn2+ binding site [ion binding]; other site
351627004086	Mg2+ binding site [ion binding]; other site
351627004087	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
351627004088	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
351627004089	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351627004090	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351627004091	catalytic residue [active]
351627004092	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
351627004093	Peptidase family M23; Region: Peptidase_M23; pfam01551
351627004094	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
351627004095	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
351627004096	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351627004097	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
351627004098	active site
351627004099	DNA binding site [nucleotide binding]
351627004100	Int/Topo IB signature motif; other site
351627004101	Radical SAM superfamily; Region: Radical_SAM; pfam04055
351627004102	Integrase core domain; Region: rve; pfam00665
351627004103	RecT family; Region: RecT; pfam03837
351627004104	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
351627004105	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
351627004106	MPN+ (JAMM) motif; other site
351627004107	Zinc-binding site [ion binding]; other site
351627004108	DNA primase, catalytic core; Region: dnaG; TIGR01391
351627004109	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
351627004110	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627004111	seryl-tRNA synthetase; Provisional; Region: PRK05431
351627004112	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
351627004113	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
351627004114	dimer interface [polypeptide binding]; other site
351627004115	active site
351627004116	motif 1; other site
351627004117	motif 2; other site
351627004118	motif 3; other site
351627004119	Uncharacterized conserved protein [Function unknown]; Region: COG0398
351627004120	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
351627004121	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175
351627004122	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
351627004123	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
351627004124	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
351627004125	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
351627004126	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
351627004127	dimer interface [polypeptide binding]; other site
351627004128	PYR/PP interface [polypeptide binding]; other site
351627004129	TPP binding site [chemical binding]; other site
351627004130	substrate binding site [chemical binding]; other site
351627004131	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
351627004132	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
351627004133	TPP-binding site [chemical binding]; other site
351627004134	putative dimer interface [polypeptide binding]; other site
351627004135	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
351627004136	Prephenate dehydratase; Region: PDT; pfam00800
351627004137	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
351627004138	putative L-Phe binding site [chemical binding]; other site
351627004139	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
351627004140	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
351627004141	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
351627004142	DHH family; Region: DHH; pfam01368
351627004143	DHHA1 domain; Region: DHHA1; pfam02272
351627004144	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
351627004145	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
351627004146	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
351627004147	replicative DNA helicase; Region: DnaB; TIGR00665
351627004148	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
351627004149	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
351627004150	Walker A motif; other site
351627004151	ATP binding site [chemical binding]; other site
351627004152	Walker B motif; other site
351627004153	DNA binding loops [nucleotide binding]
351627004154	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
351627004155	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
351627004156	homotetramer interface [polypeptide binding]; other site
351627004157	ligand binding site [chemical binding]; other site
351627004158	catalytic site [active]
351627004159	NAD binding site [chemical binding]; other site
351627004160	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
351627004161	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
351627004162	active site
351627004163	putative substrate binding pocket [chemical binding]; other site
351627004164	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
351627004165	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
351627004166	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
351627004167	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
351627004168	active site
351627004169	HIGH motif; other site
351627004170	dimer interface [polypeptide binding]; other site
351627004171	KMSKS motif; other site
351627004172	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351627004173	RNA binding surface [nucleotide binding]; other site
351627004174	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
351627004175	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
351627004176	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
351627004177	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627004178	Walker A/P-loop; other site
351627004179	ATP binding site [chemical binding]; other site
351627004180	Q-loop/lid; other site
351627004181	ABC transporter signature motif; other site
351627004182	Walker B; other site
351627004183	D-loop; other site
351627004184	H-loop/switch region; other site
351627004185	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627004186	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351627004187	Transposase domain (DUF772); Region: DUF772; pfam05598
351627004188	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627004189	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627004190	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627004191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627004192	MULE transposase domain; Region: MULE; pfam10551
351627004193	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627004194	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351627004195	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627004196	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627004197	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
351627004198	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
351627004199	Walker A/P-loop; other site
351627004200	ATP binding site [chemical binding]; other site
351627004201	Q-loop/lid; other site
351627004202	ABC transporter signature motif; other site
351627004203	Walker B; other site
351627004204	D-loop; other site
351627004205	H-loop/switch region; other site
351627004206	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
351627004207	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
351627004208	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
351627004209	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351627004210	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
351627004211	1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181
351627004212	dimer interface [polypeptide binding]; other site
351627004213	active site
351627004214	metal binding site [ion binding]; metal-binding site
351627004215	hydroxyglutarate oxidase; Provisional; Region: PRK11728
351627004216	Predicted dehydrogenase [General function prediction only]; Region: COG0579
351627004217	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
351627004218	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
351627004219	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351627004220	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
351627004221	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
351627004222	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
351627004223	Found in ATP-dependent protease La (LON); Region: LON; smart00464
351627004224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627004225	Walker A motif; other site
351627004226	ATP binding site [chemical binding]; other site
351627004227	Walker B motif; other site
351627004228	arginine finger; other site
351627004229	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
351627004230	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
351627004231	G1 box; other site
351627004232	GTP/Mg2+ binding site [chemical binding]; other site
351627004233	Switch I region; other site
351627004234	G2 box; other site
351627004235	G3 box; other site
351627004236	Switch II region; other site
351627004237	G4 box; other site
351627004238	G5 box; other site
351627004239	Uncharacterized conserved protein [Function unknown]; Region: COG1683
351627004240	Sensory domain found in PocR; Region: PocR; pfam10114
351627004241	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
351627004242	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627004243	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627004244	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627004245	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
351627004246	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
351627004247	dimer interface [polypeptide binding]; other site
351627004248	active site
351627004249	galactokinase; Provisional; Region: PRK05322
351627004250	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
351627004251	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
351627004252	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
351627004253	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
351627004254	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
351627004255	NAD binding site [chemical binding]; other site
351627004256	homodimer interface [polypeptide binding]; other site
351627004257	active site
351627004258	substrate binding site [chemical binding]; other site
351627004259	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
351627004260	transcription termination factor Rho; Provisional; Region: PRK12608
351627004261	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
351627004262	RNA binding site [nucleotide binding]; other site
351627004263	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627004264	Walker A motif; other site
351627004265	ATP binding site [chemical binding]; other site
351627004266	Walker B motif; other site
351627004267	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
351627004268	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
351627004269	active site
351627004270	metal binding site [ion binding]; metal-binding site
351627004271	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
351627004272	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
351627004273	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
351627004274	minor groove reading motif; other site
351627004275	helix-hairpin-helix signature motif; other site
351627004276	substrate binding pocket [chemical binding]; other site
351627004277	active site
351627004278	Protease prsW family; Region: PrsW-protease; pfam13367
351627004279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627004280	putative substrate translocation pore; other site
351627004281	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351627004282	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
351627004283	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
351627004284	putative active site [active]
351627004285	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
351627004286	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
351627004287	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
351627004288	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627004289	S-adenosylmethionine binding site [chemical binding]; other site
351627004290	peptide chain release factor 1; Validated; Region: prfA; PRK00591
351627004291	This domain is found in peptide chain release factors; Region: PCRF; smart00937
351627004292	RF-1 domain; Region: RF-1; pfam00472
351627004293	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
351627004294	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
351627004295	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
351627004296	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
351627004297	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
351627004298	ligand binding site [chemical binding]; other site
351627004299	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
351627004300	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
351627004301	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
351627004302	Low molecular weight phosphatase family; Region: LMWPc; cd00115
351627004303	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
351627004304	active site
351627004305	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
351627004306	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
351627004307	feedback inhibition sensing region; other site
351627004308	homohexameric interface [polypeptide binding]; other site
351627004309	nucleotide binding site [chemical binding]; other site
351627004310	N-acetyl-L-glutamate binding site [chemical binding]; other site
351627004311	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
351627004312	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
351627004313	AMIN domain; Region: AMIN; pfam11741
351627004314	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
351627004315	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
351627004316	active site
351627004317	metal binding site [ion binding]; metal-binding site
351627004318	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
351627004319	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
351627004320	active site
351627004321	motif I; other site
351627004322	motif II; other site
351627004323	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
351627004324	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009
351627004325	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
351627004326	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
351627004327	NADH dehydrogenase; Region: NADHdh; cl00469
351627004328	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
351627004329	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
351627004330	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
351627004331	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
351627004332	4Fe-4S binding domain; Region: Fer4; cl02805
351627004333	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
351627004334	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
351627004335	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
351627004336	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
351627004337	Acylphosphatase; Region: Acylphosphatase; pfam00708
351627004338	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
351627004339	HypF finger; Region: zf-HYPF; pfam07503
351627004340	HypF finger; Region: zf-HYPF; pfam07503
351627004341	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
351627004342	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
351627004343	HupF/HypC family; Region: HupF_HypC; pfam01455
351627004344	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
351627004345	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
351627004346	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
351627004347	dimerization interface [polypeptide binding]; other site
351627004348	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
351627004349	ATP binding site [chemical binding]; other site
351627004350	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
351627004351	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
351627004352	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351627004353	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
351627004354	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
351627004355	dimer interface [polypeptide binding]; other site
351627004356	PYR/PP interface [polypeptide binding]; other site
351627004357	TPP binding site [chemical binding]; other site
351627004358	substrate binding site [chemical binding]; other site
351627004359	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
351627004360	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
351627004361	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
351627004362	TPP-binding site [chemical binding]; other site
351627004363	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
351627004364	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
351627004365	VanW like protein; Region: VanW; pfam04294
351627004366	G5 domain; Region: G5; pfam07501
351627004367	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
351627004368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
351627004369	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
351627004370	Predicted transcriptional regulator [Transcription]; Region: COG4189
351627004371	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
351627004372	dimerization interface [polypeptide binding]; other site
351627004373	putative DNA binding site [nucleotide binding]; other site
351627004374	putative Zn2+ binding site [ion binding]; other site
351627004375	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627004376	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627004377	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627004378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627004379	dimer interface [polypeptide binding]; other site
351627004380	conserved gate region; other site
351627004381	putative PBP binding loops; other site
351627004382	ABC-ATPase subunit interface; other site
351627004383	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627004384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627004385	dimer interface [polypeptide binding]; other site
351627004386	conserved gate region; other site
351627004387	putative PBP binding loops; other site
351627004388	ABC-ATPase subunit interface; other site
351627004389	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
351627004390	substrate binding site [chemical binding]; other site
351627004391	active site
351627004392	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
351627004393	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
351627004394	alpha-galactosidase; Provisional; Region: PRK15076
351627004395	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
351627004396	NAD binding site [chemical binding]; other site
351627004397	sugar binding site [chemical binding]; other site
351627004398	divalent metal binding site [ion binding]; other site
351627004399	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
351627004400	dimer interface [polypeptide binding]; other site
351627004401	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
351627004402	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351627004403	Coenzyme A binding pocket [chemical binding]; other site
351627004404	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
351627004405	active site
351627004406	putative DNA-binding cleft [nucleotide binding]; other site
351627004407	dimer interface [polypeptide binding]; other site
351627004408	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
351627004409	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
351627004410	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627004411	Walker A motif; other site
351627004412	ATP binding site [chemical binding]; other site
351627004413	Walker B motif; other site
351627004414	arginine finger; other site
351627004415	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
351627004416	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
351627004417	Ligand Binding Site [chemical binding]; other site
351627004418	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
351627004419	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
351627004420	hypothetical protein; Provisional; Region: PRK14553
351627004421	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
351627004422	GTPase CgtA; Reviewed; Region: obgE; PRK12297
351627004423	GTP1/OBG; Region: GTP1_OBG; pfam01018
351627004424	Obg GTPase; Region: Obg; cd01898
351627004425	G1 box; other site
351627004426	GTP/Mg2+ binding site [chemical binding]; other site
351627004427	Switch I region; other site
351627004428	G2 box; other site
351627004429	G3 box; other site
351627004430	Switch II region; other site
351627004431	G4 box; other site
351627004432	G5 box; other site
351627004433	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
351627004434	Integrase core domain; Region: rve; pfam00665
351627004435	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
351627004436	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
351627004437	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
351627004438	homodimer interface [polypeptide binding]; other site
351627004439	substrate-cofactor binding pocket; other site
351627004440	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627004441	catalytic residue [active]
351627004442	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
351627004443	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
351627004444	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
351627004445	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
351627004446	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
351627004447	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
351627004448	active site
351627004449	aspartate aminotransferase; Provisional; Region: PRK05764
351627004450	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351627004451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627004452	homodimer interface [polypeptide binding]; other site
351627004453	catalytic residue [active]
351627004454	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
351627004455	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
351627004456	tetramer interface [polypeptide binding]; other site
351627004457	active site
351627004458	reverse gyrase; Reviewed; Region: PRK09401
351627004459	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351627004460	ATP binding site [chemical binding]; other site
351627004461	putative Mg++ binding site [ion binding]; other site
351627004462	TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove; Region: TOPRIM_TopoIA_RevGyr; cd03361
351627004463	active site
351627004464	putative interdomain interaction site [polypeptide binding]; other site
351627004465	putative metal-binding site [ion binding]; other site
351627004466	putative nucleotide binding site [chemical binding]; other site
351627004467	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
351627004468	domain I; other site
351627004469	DNA binding groove [nucleotide binding]
351627004470	phosphate binding site [ion binding]; other site
351627004471	domain II; other site
351627004472	domain III; other site
351627004473	nucleotide binding site [chemical binding]; other site
351627004474	catalytic site [active]
351627004475	domain IV; other site
351627004476	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
351627004477	putative allosteric regulatory site; other site
351627004478	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
351627004479	putative allosteric regulatory residue; other site
351627004480	dihydrodipicolinate reductase; Provisional; Region: PRK00048
351627004481	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
351627004482	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
351627004483	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
351627004484	dihydrodipicolinate synthase; Region: dapA; TIGR00674
351627004485	dimer interface [polypeptide binding]; other site
351627004486	active site
351627004487	catalytic residue [active]
351627004488	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
351627004489	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
351627004490	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
351627004491	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
351627004492	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627004493	active site
351627004494	NTP binding site [chemical binding]; other site
351627004495	metal binding triad [ion binding]; metal-binding site
351627004496	antibiotic binding site [chemical binding]; other site
351627004497	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
351627004498	homotrimer interaction site [polypeptide binding]; other site
351627004499	zinc binding site [ion binding]; other site
351627004500	CDP-binding sites; other site
351627004501	NurA nuclease; Region: NurA; smart00933
351627004502	Domain of unknown function DUF87; Region: DUF87; pfam01935
351627004503	AAA-like domain; Region: AAA_10; pfam12846
351627004504	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
351627004505	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
351627004506	active site
351627004507	metal binding site [ion binding]; metal-binding site
351627004508	DNA binding site [nucleotide binding]
351627004509	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
351627004510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627004511	Walker A/P-loop; other site
351627004512	ATP binding site [chemical binding]; other site
351627004513	Q-loop/lid; other site
351627004514	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627004515	ABC transporter signature motif; other site
351627004516	Walker B; other site
351627004517	D-loop; other site
351627004518	H-loop/switch region; other site
351627004519	hypothetical protein; Validated; Region: PRK00153
351627004520	recombination protein RecR; Reviewed; Region: recR; PRK00076
351627004521	RecR protein; Region: RecR; pfam02132
351627004522	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
351627004523	putative active site [active]
351627004524	putative metal-binding site [ion binding]; other site
351627004525	tetramer interface [polypeptide binding]; other site
351627004526	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
351627004527	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
351627004528	NAD(P) binding site [chemical binding]; other site
351627004529	active site
351627004530	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
351627004531	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
351627004532	active site
351627004533	tetramer interface; other site
351627004534	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
351627004535	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
351627004536	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
351627004537	active site 1 [active]
351627004538	active site 2 [active]
351627004539	putative phosphate acyltransferase; Provisional; Region: PRK05331
351627004540	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
351627004541	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
351627004542	dimer interface [polypeptide binding]; other site
351627004543	active site
351627004544	CoA binding pocket [chemical binding]; other site
351627004545	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
351627004546	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
351627004547	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
351627004548	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
351627004549	NAD(P) binding site [chemical binding]; other site
351627004550	homotetramer interface [polypeptide binding]; other site
351627004551	homodimer interface [polypeptide binding]; other site
351627004552	active site
351627004553	acyl carrier protein; Provisional; Region: acpP; PRK00982
351627004554	ribonuclease III; Reviewed; Region: rnc; PRK00102
351627004555	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
351627004556	dimerization interface [polypeptide binding]; other site
351627004557	active site
351627004558	metal binding site [ion binding]; metal-binding site
351627004559	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
351627004560	dsRNA binding site [nucleotide binding]; other site
351627004561	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
351627004562	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627004563	FeS/SAM binding site; other site
351627004564	PBP superfamily domain; Region: PBP_like_2; cl17296
351627004565	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
351627004566	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
351627004567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627004568	dimer interface [polypeptide binding]; other site
351627004569	conserved gate region; other site
351627004570	putative PBP binding loops; other site
351627004571	ABC-ATPase subunit interface; other site
351627004572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
351627004573	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
351627004574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627004575	dimer interface [polypeptide binding]; other site
351627004576	conserved gate region; other site
351627004577	putative PBP binding loops; other site
351627004578	ABC-ATPase subunit interface; other site
351627004579	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
351627004580	Integrase core domain; Region: rve; pfam00665
351627004581	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
351627004582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627004583	dimer interface [polypeptide binding]; other site
351627004584	conserved gate region; other site
351627004585	ABC-ATPase subunit interface; other site
351627004586	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
351627004587	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
351627004588	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
351627004589	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
351627004590	Walker A/P-loop; other site
351627004591	ATP binding site [chemical binding]; other site
351627004592	Q-loop/lid; other site
351627004593	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
351627004594	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
351627004595	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
351627004596	ABC transporter signature motif; other site
351627004597	Walker B; other site
351627004598	D-loop; other site
351627004599	H-loop/switch region; other site
351627004600	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
351627004601	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
351627004602	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
351627004603	P loop; other site
351627004604	GTP binding site [chemical binding]; other site
351627004605	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
351627004606	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
351627004607	ligand binding site [chemical binding]; other site
351627004608	flexible hinge region; other site
351627004609	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
351627004610	Ferredoxin [Energy production and conversion]; Region: COG1146
351627004611	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
351627004612	hybrid cluster protein; Provisional; Region: PRK05290
351627004613	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
351627004614	ACS interaction site; other site
351627004615	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
351627004616	hybrid metal cluster; other site
351627004617	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
351627004618	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
351627004619	ATP-grasp domain; Region: ATP-grasp; pfam02222
351627004620	AIR carboxylase; Region: AIRC; pfam00731
351627004621	NMT1-like family; Region: NMT1_2; pfam13379
351627004622	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
351627004623	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
351627004624	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
351627004625	Walker A/P-loop; other site
351627004626	ATP binding site [chemical binding]; other site
351627004627	Q-loop/lid; other site
351627004628	ABC transporter signature motif; other site
351627004629	Walker B; other site
351627004630	D-loop; other site
351627004631	H-loop/switch region; other site
351627004632	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
351627004633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627004634	dimer interface [polypeptide binding]; other site
351627004635	conserved gate region; other site
351627004636	putative PBP binding loops; other site
351627004637	ABC-ATPase subunit interface; other site
351627004638	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
351627004639	thiS-thiF/thiG interaction site; other site
351627004640	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
351627004641	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
351627004642	ATP binding site [chemical binding]; other site
351627004643	substrate interface [chemical binding]; other site
351627004644	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
351627004645	MPN+ (JAMM) motif; other site
351627004646	Zinc-binding site [ion binding]; other site
351627004647	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
351627004648	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
351627004649	4Fe-4S binding domain; Region: Fer4; pfam00037
351627004650	4Fe-4S binding domain; Region: Fer4; pfam00037
351627004651	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
351627004652	CPxP  motif; other site
351627004653	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
351627004654	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
351627004655	homodimer interface [polypeptide binding]; other site
351627004656	substrate-cofactor binding pocket; other site
351627004657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627004658	catalytic residue [active]
351627004659	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
351627004660	L-aspartate oxidase; Provisional; Region: PRK06175
351627004661	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
351627004662	Ferredoxin [Energy production and conversion]; Region: COG1146
351627004663	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
351627004664	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
351627004665	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
351627004666	Active Sites [active]
351627004667	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
351627004668	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
351627004669	G1 box; other site
351627004670	GTP/Mg2+ binding site [chemical binding]; other site
351627004671	G2 box; other site
351627004672	Switch I region; other site
351627004673	G3 box; other site
351627004674	Switch II region; other site
351627004675	G4 box; other site
351627004676	G5 box; other site
351627004677	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
351627004678	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
351627004679	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
351627004680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
351627004681	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
351627004682	putative dimerization interface [polypeptide binding]; other site
351627004683	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
351627004684	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
351627004685	DsrE/DsrF-like family; Region: DrsE; cl00672
351627004686	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
351627004687	TatD related DNase; Region: TatD_DNase; pfam01026
351627004688	active site
351627004689	Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007
351627004690	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
351627004691	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
351627004692	tRNA; other site
351627004693	putative tRNA binding site [nucleotide binding]; other site
351627004694	putative NADP binding site [chemical binding]; other site
351627004695	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
351627004696	precorrin-2 dehydrogenase; Provisional; Region: PRK05562
351627004697	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
351627004698	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
351627004699	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
351627004700	domain interfaces; other site
351627004701	active site
351627004702	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
351627004703	active site
351627004704	SAM binding site [chemical binding]; other site
351627004705	homodimer interface [polypeptide binding]; other site
351627004706	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
351627004707	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
351627004708	active site
351627004709	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
351627004710	dimer interface [polypeptide binding]; other site
351627004711	active site
351627004712	Schiff base residues; other site
351627004713	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
351627004714	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351627004715	inhibitor-cofactor binding pocket; inhibition site
351627004716	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627004717	catalytic residue [active]
351627004718	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
351627004719	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
351627004720	Ligand Binding Site [chemical binding]; other site
351627004721	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
351627004722	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
351627004723	dimer interface [polypeptide binding]; other site
351627004724	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
351627004725	anti sigma factor interaction site; other site
351627004726	regulatory phosphorylation site [posttranslational modification]; other site
351627004727	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
351627004728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627004729	ATP binding site [chemical binding]; other site
351627004730	Mg2+ binding site [ion binding]; other site
351627004731	G-X-G motif; other site
351627004732	sporulation sigma factor SigF; Validated; Region: PRK05572
351627004733	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627004734	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
351627004735	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627004736	DNA binding residues [nucleotide binding]
351627004737	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
351627004738	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627004739	active site
351627004740	flagellar operon protein TIGR03826; Region: YvyF
351627004741	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
351627004742	FlgN protein; Region: FlgN; pfam05130
351627004743	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
351627004744	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
351627004745	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
351627004746	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
351627004747	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
351627004748	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627004749	active site
351627004750	NTP binding site [chemical binding]; other site
351627004751	metal binding triad [ion binding]; metal-binding site
351627004752	antibiotic binding site [chemical binding]; other site
351627004753	Transposase [DNA replication, recombination, and repair]; Region: COG5421
351627004754	Protein of unknown function DUF86; Region: DUF86; pfam01934
351627004755	flagellar assembly protein FliW; Provisional; Region: PRK13285
351627004756	Global regulator protein family; Region: CsrA; pfam02599
351627004757	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627004758	active site
351627004759	NTP binding site [chemical binding]; other site
351627004760	metal binding triad [ion binding]; metal-binding site
351627004761	antibiotic binding site [chemical binding]; other site
351627004762	Protein of unknown function DUF86; Region: DUF86; pfam01934
351627004763	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
351627004764	AAA domain; Region: AAA_14; pfam13173
351627004765	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
351627004766	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
351627004767	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
351627004768	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351627004769	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
351627004770	ATP binding site [chemical binding]; other site
351627004771	putative Mg++ binding site [ion binding]; other site
351627004772	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351627004773	nucleotide binding region [chemical binding]; other site
351627004774	ATP-binding site [chemical binding]; other site
351627004775	flagellin; Provisional; Region: PRK12804
351627004776	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
351627004777	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
351627004778	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
351627004779	putative metal binding site; other site
351627004780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
351627004781	TPR motif; other site
351627004782	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351627004783	binding surface
351627004784	TPR motif; other site
351627004785	TPR repeat; Region: TPR_11; pfam13414
351627004786	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627004787	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
351627004788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627004789	S-adenosylmethionine binding site [chemical binding]; other site
351627004790	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
351627004791	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627004792	Zn2+ binding site [ion binding]; other site
351627004793	Mg2+ binding site [ion binding]; other site
351627004794	Uncharacterized conserved protein [Function unknown]; Region: COG3465
351627004795	potential frameshift: common BLAST hit: gi|146297321|ref|YP_001181092.1| transposase, IS4 family protein
351627004796	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627004797	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
351627004798	Transposase domain (DUF772); Region: DUF772; pfam05598
351627004799	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627004800	Integrase core domain; Region: rve; pfam00665
351627004801	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
351627004802	Preprotein binding site; other site
351627004803	SecA binding site; other site
351627004804	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627004805	active site
351627004806	NTP binding site [chemical binding]; other site
351627004807	metal binding triad [ion binding]; metal-binding site
351627004808	HEPN domain; Region: HEPN; pfam05168
351627004809	FlaG protein; Region: FlaG; pfam03646
351627004810	flagellar capping protein; Validated; Region: fliD; PRK07737
351627004811	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
351627004812	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
351627004813	Flagellar protein FliS; Region: FliS; cl00654
351627004814	FlgN protein; Region: FlgN; pfam05130
351627004815	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
351627004816	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
351627004817	potential frameshift: common BLAST hit: gi|312793842|ref|YP_004026765.1| major facilitator superfamily protein
351627004818	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
351627004819	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
351627004820	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
351627004821	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
351627004822	gamma-glutamyl kinase; Provisional; Region: PRK05429
351627004823	nucleotide binding site [chemical binding]; other site
351627004824	homotetrameric interface [polypeptide binding]; other site
351627004825	putative phosphate binding site [ion binding]; other site
351627004826	putative allosteric binding site; other site
351627004827	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
351627004828	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
351627004829	putative catalytic cysteine [active]
351627004830	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627004831	active site
351627004832	NTP binding site [chemical binding]; other site
351627004833	metal binding triad [ion binding]; metal-binding site
351627004834	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
351627004835	MutS domain III; Region: MutS_III; pfam05192
351627004836	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
351627004837	Walker A/P-loop; other site
351627004838	ATP binding site [chemical binding]; other site
351627004839	Q-loop/lid; other site
351627004840	ABC transporter signature motif; other site
351627004841	Walker B; other site
351627004842	D-loop; other site
351627004843	H-loop/switch region; other site
351627004844	Smr domain; Region: Smr; pfam01713
351627004845	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
351627004846	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
351627004847	Catalytic site [active]
351627004848	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
351627004849	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
351627004850	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
351627004851	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
351627004852	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
351627004853	active site
351627004854	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
351627004855	active site
351627004856	catalytic residues [active]
351627004857	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
351627004858	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
351627004859	Ligand Binding Site [chemical binding]; other site
351627004860	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
351627004861	AIR carboxylase; Region: AIRC; smart01001
351627004862	Protein of unknown function DUF111; Region: DUF111; cl03398
351627004863	Protein of unknown function DUF111; Region: DUF111; cl03398
351627004864	GTP-binding protein YchF; Reviewed; Region: PRK09601
351627004865	YchF GTPase; Region: YchF; cd01900
351627004866	G1 box; other site
351627004867	GTP/Mg2+ binding site [chemical binding]; other site
351627004868	Switch I region; other site
351627004869	G2 box; other site
351627004870	Switch II region; other site
351627004871	G3 box; other site
351627004872	G4 box; other site
351627004873	G5 box; other site
351627004874	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
351627004875	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
351627004876	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351627004877	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351627004878	catalytic residue [active]
351627004879	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
351627004880	Heme NO binding; Region: HNOB; pfam07700
351627004881	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351627004882	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627004883	dimer interface [polypeptide binding]; other site
351627004884	putative CheW interface [polypeptide binding]; other site
351627004885	Predicted membrane protein [Function unknown]; Region: COG2510
351627004886	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
351627004887	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627004888	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627004889	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627004890	Uncharacterized conserved protein [Function unknown]; Region: COG2968
351627004891	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
351627004892	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
351627004893	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
351627004894	catalytic residues [active]
351627004895	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
351627004896	putative homodimer interface [polypeptide binding]; other site
351627004897	putative homotetramer interface [polypeptide binding]; other site
351627004898	putative allosteric switch controlling residues; other site
351627004899	putative metal binding site [ion binding]; other site
351627004900	putative homodimer-homodimer interface [polypeptide binding]; other site
351627004901	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627004902	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
351627004903	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
351627004904	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
351627004905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627004906	S-adenosylmethionine binding site [chemical binding]; other site
351627004907	Uncharacterized conserved protein [Function unknown]; Region: COG0327
351627004908	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
351627004909	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
351627004910	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
351627004911	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
351627004912	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
351627004913	nucleotide binding pocket [chemical binding]; other site
351627004914	K-X-D-G motif; other site
351627004915	catalytic site [active]
351627004916	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
351627004917	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
351627004918	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
351627004919	Dimer interface [polypeptide binding]; other site
351627004920	BRCT sequence motif; other site
351627004921	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
351627004922	ABC1 family; Region: ABC1; cl17513
351627004923	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
351627004924	active site
351627004925	ATP binding site [chemical binding]; other site
351627004926	Uncharacterized conserved protein [Function unknown]; Region: COG3937
351627004927	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
351627004928	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
351627004929	dimer interface [polypeptide binding]; other site
351627004930	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627004931	catalytic residue [active]
351627004932	probable regulatory domain; Region: near_KaiC_dom; TIGR03879
351627004933	KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878
351627004934	KaiC; Region: KaiC; pfam06745
351627004935	Walker A motif; other site
351627004936	ATP binding site [chemical binding]; other site
351627004937	Walker B motif; other site
351627004938	FeoA domain; Region: FeoA; pfam04023
351627004939	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
351627004940	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
351627004941	G1 box; other site
351627004942	GTP/Mg2+ binding site [chemical binding]; other site
351627004943	Switch I region; other site
351627004944	G2 box; other site
351627004945	G3 box; other site
351627004946	Switch II region; other site
351627004947	G4 box; other site
351627004948	G5 box; other site
351627004949	Nucleoside recognition; Region: Gate; pfam07670
351627004950	Nucleoside recognition; Region: Gate; pfam07670
351627004951	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
351627004952	metal binding site 2 [ion binding]; metal-binding site
351627004953	putative DNA binding helix; other site
351627004954	metal binding site 1 [ion binding]; metal-binding site
351627004955	dimer interface [polypeptide binding]; other site
351627004956	structural Zn2+ binding site [ion binding]; other site
351627004957	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
351627004958	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
351627004959	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
351627004960	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
351627004961	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
351627004962	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
351627004963	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
351627004964	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627004965	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
351627004966	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351627004967	RNA binding surface [nucleotide binding]; other site
351627004968	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
351627004969	active site
351627004970	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
351627004971	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
351627004972	putative active site [active]
351627004973	putative metal binding site [ion binding]; other site
351627004974	GTP-binding protein LepA; Provisional; Region: PRK05433
351627004975	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
351627004976	G1 box; other site
351627004977	putative GEF interaction site [polypeptide binding]; other site
351627004978	GTP/Mg2+ binding site [chemical binding]; other site
351627004979	Switch I region; other site
351627004980	G2 box; other site
351627004981	G3 box; other site
351627004982	Switch II region; other site
351627004983	G4 box; other site
351627004984	G5 box; other site
351627004985	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
351627004986	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
351627004987	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
351627004988	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
351627004989	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627004990	FeS/SAM binding site; other site
351627004991	HemN C-terminal domain; Region: HemN_C; pfam06969
351627004992	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
351627004993	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
351627004994	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
351627004995	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
351627004996	dimer interface [polypeptide binding]; other site
351627004997	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
351627004998	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
351627004999	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
351627005000	nucleotide binding site [chemical binding]; other site
351627005001	NEF interaction site [polypeptide binding]; other site
351627005002	SBD interface [polypeptide binding]; other site
351627005003	chaperone protein DnaJ; Provisional; Region: PRK14277
351627005004	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
351627005005	HSP70 interaction site [polypeptide binding]; other site
351627005006	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
351627005007	substrate binding site [polypeptide binding]; other site
351627005008	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
351627005009	Zn binding sites [ion binding]; other site
351627005010	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
351627005011	dimer interface [polypeptide binding]; other site
351627005012	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
351627005013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
351627005014	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
351627005015	RNA methyltransferase, RsmE family; Region: TIGR00046
351627005016	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
351627005017	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
351627005018	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351627005019	catalytic residue [active]
351627005020	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
351627005021	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
351627005022	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
351627005023	Ligand Binding Site [chemical binding]; other site
351627005024	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351627005025	RNA binding surface [nucleotide binding]; other site
351627005026	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
351627005027	pseudouridine synthase; Region: TIGR00093
351627005028	active site
351627005029	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
351627005030	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
351627005031	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
351627005032	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
351627005033	Walker A/P-loop; other site
351627005034	ATP binding site [chemical binding]; other site
351627005035	Q-loop/lid; other site
351627005036	ABC transporter signature motif; other site
351627005037	Walker B; other site
351627005038	D-loop; other site
351627005039	H-loop/switch region; other site
351627005040	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
351627005041	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
351627005042	Walker A/P-loop; other site
351627005043	ATP binding site [chemical binding]; other site
351627005044	Q-loop/lid; other site
351627005045	ABC transporter signature motif; other site
351627005046	Walker B; other site
351627005047	D-loop; other site
351627005048	H-loop/switch region; other site
351627005049	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
351627005050	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
351627005051	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
351627005052	dimerization interface 3.5A [polypeptide binding]; other site
351627005053	active site
351627005054	Integrase core domain; Region: rve; pfam00665
351627005055	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
351627005056	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
351627005057	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
351627005058	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
351627005059	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
351627005060	23S rRNA binding site [nucleotide binding]; other site
351627005061	L21 binding site [polypeptide binding]; other site
351627005062	L13 binding site [polypeptide binding]; other site
351627005063	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
351627005064	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
351627005065	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
351627005066	hypothetical protein; Provisional; Region: PRK05473
351627005067	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
351627005068	active site
351627005069	catalytic tetrad [active]
351627005070	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
351627005071	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
351627005072	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
351627005073	Quinolinate synthetase A protein; Region: NadA; pfam02445
351627005074	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
351627005075	L-aspartate oxidase; Provisional; Region: PRK06175
351627005076	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
351627005077	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
351627005078	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
351627005079	dimerization interface [polypeptide binding]; other site
351627005080	active site
351627005081	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
351627005082	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
351627005083	putative [4Fe-4S] binding site [ion binding]; other site
351627005084	putative molybdopterin cofactor binding site [chemical binding]; other site
351627005085	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
351627005086	molybdopterin cofactor binding site; other site
351627005087	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
351627005088	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
351627005089	GTP binding site; other site
351627005090	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
351627005091	nudix motif; other site
351627005092	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
351627005093	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
351627005094	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
351627005095	putative RNA binding site [nucleotide binding]; other site
351627005096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627005097	S-adenosylmethionine binding site [chemical binding]; other site
351627005098	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
351627005099	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627005100	S-adenosylmethionine binding site [chemical binding]; other site
351627005101	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
351627005102	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
351627005103	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351627005104	RNA binding surface [nucleotide binding]; other site
351627005105	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
351627005106	active site
351627005107	uracil binding [chemical binding]; other site
351627005108	Predicted membrane protein [Function unknown]; Region: COG3601
351627005109	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
351627005110	Asp23 family; Region: Asp23; pfam03780
351627005111	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
351627005112	DAK2 domain; Region: Dak2; pfam02734
351627005113	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
351627005114	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
351627005115	generic binding surface II; other site
351627005116	ssDNA binding site; other site
351627005117	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351627005118	ATP binding site [chemical binding]; other site
351627005119	putative Mg++ binding site [ion binding]; other site
351627005120	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351627005121	nucleotide binding region [chemical binding]; other site
351627005122	ATP-binding site [chemical binding]; other site
351627005123	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
351627005124	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
351627005125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627005126	S-adenosylmethionine binding site [chemical binding]; other site
351627005127	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
351627005128	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
351627005129	active site
351627005130	(T/H)XGH motif; other site
351627005131	phosphodiesterase; Provisional; Region: PRK12704
351627005132	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
351627005133	Nucleoside recognition; Region: Gate; pfam07670
351627005134	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
351627005135	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
351627005136	active site
351627005137	nucleophile elbow; other site
351627005138	hypothetical protein; Provisional; Region: PRK13670
351627005139	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
351627005140	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
351627005141	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
351627005142	active site
351627005143	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
351627005144	Ligand binding site [chemical binding]; other site
351627005145	Electron transfer flavoprotein domain; Region: ETF; pfam01012
351627005146	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
351627005147	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
351627005148	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
351627005149	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
351627005150	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
351627005151	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
351627005152	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
351627005153	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
351627005154	inhibitor-cofactor binding pocket; inhibition site
351627005155	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627005156	catalytic residue [active]
351627005157	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
351627005158	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
351627005159	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
351627005160	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
351627005161	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
351627005162	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
351627005163	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
351627005164	putative trimer interface [polypeptide binding]; other site
351627005165	putative CoA binding site [chemical binding]; other site
351627005166	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
351627005167	putative trimer interface [polypeptide binding]; other site
351627005168	putative active site [active]
351627005169	putative substrate binding site [chemical binding]; other site
351627005170	putative CoA binding site [chemical binding]; other site
351627005171	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
351627005172	O-Antigen ligase; Region: Wzy_C; pfam04932
351627005173	O-Antigen ligase; Region: Wzy_C; cl04850
351627005174	O-Antigen ligase; Region: Wzy_C; pfam04932
351627005175	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627005176	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
351627005177	Transcriptional regulator [Transcription]; Region: LytR; COG1316
351627005178	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
351627005179	Protein of unknown function, DUF624; Region: DUF624; pfam04854
351627005180	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
351627005181	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
351627005182	5S rRNA interface [nucleotide binding]; other site
351627005183	CTC domain interface [polypeptide binding]; other site
351627005184	L16 interface [polypeptide binding]; other site
351627005185	argininosuccinate lyase; Provisional; Region: PRK00855
351627005186	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
351627005187	active sites [active]
351627005188	tetramer interface [polypeptide binding]; other site
351627005189	argininosuccinate synthase; Provisional; Region: PRK13820
351627005190	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
351627005191	ANP binding site [chemical binding]; other site
351627005192	Substrate Binding Site II [chemical binding]; other site
351627005193	Substrate Binding Site I [chemical binding]; other site
351627005194	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
351627005195	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
351627005196	active site
351627005197	(T/H)XGH motif; other site
351627005198	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627005199	Zn2+ binding site [ion binding]; other site
351627005200	Mg2+ binding site [ion binding]; other site
351627005201	Transcriptional regulator [Transcription]; Region: LytR; COG1316
351627005202	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
351627005203	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
351627005204	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
351627005205	HIGH motif; other site
351627005206	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
351627005207	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
351627005208	active site
351627005209	KMSKS motif; other site
351627005210	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
351627005211	tRNA binding surface [nucleotide binding]; other site
351627005212	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
351627005213	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
351627005214	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
351627005215	SLBB domain; Region: SLBB; pfam10531
351627005216	comEA protein; Region: comE; TIGR01259
351627005217	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
351627005218	Integrase core domain; Region: rve; pfam00665
351627005219	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
351627005220	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
351627005221	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
351627005222	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
351627005223	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
351627005224	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627005225	Zn2+ binding site [ion binding]; other site
351627005226	Mg2+ binding site [ion binding]; other site
351627005227	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
351627005228	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
351627005229	active site
351627005230	PHP Thumb interface [polypeptide binding]; other site
351627005231	metal binding site [ion binding]; metal-binding site
351627005232	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
351627005233	generic binding surface II; other site
351627005234	generic binding surface I; other site
351627005235	transcription attenuation protein MtrB; Provisional; Region: PRK13251
351627005236	6-phosphofructokinase; Provisional; Region: PRK03202
351627005237	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
351627005238	active site
351627005239	ADP/pyrophosphate binding site [chemical binding]; other site
351627005240	dimerization interface [polypeptide binding]; other site
351627005241	allosteric effector site; other site
351627005242	fructose-1,6-bisphosphate binding site; other site
351627005243	pyruvate kinase; Provisional; Region: PRK06354
351627005244	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
351627005245	domain interfaces; other site
351627005246	active site
351627005247	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
351627005248	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
351627005249	active site
351627005250	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
351627005251	Yqey-like protein; Region: YqeY; pfam09424
351627005252	YabP family; Region: YabP; cl06766
351627005253	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
351627005254	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
351627005255	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
351627005256	PhoH-like protein; Region: PhoH; pfam02562
351627005257	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
351627005258	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627005259	Zn2+ binding site [ion binding]; other site
351627005260	Mg2+ binding site [ion binding]; other site
351627005261	metal-binding heat shock protein; Provisional; Region: PRK00016
351627005262	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
351627005263	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
351627005264	active site
351627005265	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
351627005266	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
351627005267	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
351627005268	Beta-Casp domain; Region: Beta-Casp; smart01027
351627005269	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
351627005270	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
351627005271	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
351627005272	Tetramer interface [polypeptide binding]; other site
351627005273	active site
351627005274	FMN-binding site [chemical binding]; other site
351627005275	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
351627005276	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
351627005277	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
351627005278	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
351627005279	regulatory protein interface [polypeptide binding]; other site
351627005280	regulatory phosphorylation site [posttranslational modification]; other site
351627005281	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
351627005282	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
351627005283	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627005284	FeS/SAM binding site; other site
351627005285	TRAM domain; Region: TRAM; cl01282
351627005286	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
351627005287	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
351627005288	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
351627005289	dimer interface [polypeptide binding]; other site
351627005290	motif 1; other site
351627005291	active site
351627005292	motif 2; other site
351627005293	motif 3; other site
351627005294	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
351627005295	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
351627005296	putative tRNA-binding site [nucleotide binding]; other site
351627005297	B3/4 domain; Region: B3_4; pfam03483
351627005298	tRNA synthetase B5 domain; Region: B5; smart00874
351627005299	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
351627005300	dimer interface [polypeptide binding]; other site
351627005301	motif 1; other site
351627005302	motif 3; other site
351627005303	motif 2; other site
351627005304	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
351627005305	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
351627005306	Part of AAA domain; Region: AAA_19; pfam13245
351627005307	Family description; Region: UvrD_C_2; pfam13538
351627005308	Divergent PAP2 family; Region: DUF212; pfam02681
351627005309	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
351627005310	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
351627005311	TPP-binding site; other site
351627005312	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
351627005313	PYR/PP interface [polypeptide binding]; other site
351627005314	dimer interface [polypeptide binding]; other site
351627005315	TPP binding site [chemical binding]; other site
351627005316	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
351627005317	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
351627005318	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351627005319	RNA binding surface [nucleotide binding]; other site
351627005320	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627005321	S-adenosylmethionine binding site [chemical binding]; other site
351627005322	DRTGG domain; Region: DRTGG; pfam07085
351627005323	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
351627005324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627005325	ATP binding site [chemical binding]; other site
351627005326	Mg2+ binding site [ion binding]; other site
351627005327	G-X-G motif; other site
351627005328	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
351627005329	4Fe-4S binding domain; Region: Fer4_6; pfam12837
351627005330	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
351627005331	Putative Fe-S cluster; Region: FeS; cl17515
351627005332	DRTGG domain; Region: DRTGG; pfam07085
351627005333	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
351627005334	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
351627005335	active site
351627005336	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
351627005337	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
351627005338	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
351627005339	putative dimer interface [polypeptide binding]; other site
351627005340	[2Fe-2S] cluster binding site [ion binding]; other site
351627005341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351627005342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627005343	ATP binding site [chemical binding]; other site
351627005344	Mg2+ binding site [ion binding]; other site
351627005345	G-X-G motif; other site
351627005346	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
351627005347	dimer interface [polypeptide binding]; other site
351627005348	[2Fe-2S] cluster binding site [ion binding]; other site
351627005349	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
351627005350	dimer interface [polypeptide binding]; other site
351627005351	[2Fe-2S] cluster binding site [ion binding]; other site
351627005352	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
351627005353	SLBB domain; Region: SLBB; pfam10531
351627005354	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
351627005355	4Fe-4S binding domain; Region: Fer4; pfam00037
351627005356	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
351627005357	4Fe-4S binding domain; Region: Fer4; pfam00037
351627005358	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
351627005359	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
351627005360	catalytic loop [active]
351627005361	iron binding site [ion binding]; other site
351627005362	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
351627005363	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
351627005364	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
351627005365	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
351627005366	Maf-like protein; Reviewed; Region: PRK00078
351627005367	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
351627005368	active site
351627005369	dimer interface [polypeptide binding]; other site
351627005370	rod shape-determining protein MreB; Provisional; Region: PRK13927
351627005371	MreB and similar proteins; Region: MreB_like; cd10225
351627005372	nucleotide binding site [chemical binding]; other site
351627005373	Mg binding site [ion binding]; other site
351627005374	putative protofilament interaction site [polypeptide binding]; other site
351627005375	RodZ interaction site [polypeptide binding]; other site
351627005376	rod shape-determining protein MreC; Provisional; Region: PRK13922
351627005377	rod shape-determining protein MreC; Region: MreC; pfam04085
351627005378	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
351627005379	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
351627005380	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
351627005381	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
351627005382	septum formation inhibitor; Reviewed; Region: minC; PRK00513
351627005383	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
351627005384	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
351627005385	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
351627005386	P-loop; other site
351627005387	ADP binding residues [chemical binding]; other site
351627005388	Switch I; other site
351627005389	Switch II; other site
351627005390	Septum formation topological specificity factor MinE; Region: MinE; cl00538
351627005391	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
351627005392	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
351627005393	active site
351627005394	dimer interfaces [polypeptide binding]; other site
351627005395	catalytic residues [active]
351627005396	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
351627005397	Protein of unknown function DUF115; Region: MAF_flag10; cl17471
351627005398	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
351627005399	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
351627005400	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
351627005401	active site
351627005402	spermidine synthase; Provisional; Region: PRK00811
351627005403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627005404	S-adenosylmethionine binding site [chemical binding]; other site
351627005405	agmatinase; Region: agmatinase; TIGR01230
351627005406	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
351627005407	putative active site [active]
351627005408	Mn binding site [ion binding]; other site
351627005409	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
351627005410	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
351627005411	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
351627005412	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
351627005413	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
351627005414	carboxyltransferase (CT) interaction site; other site
351627005415	biotinylation site [posttranslational modification]; other site
351627005416	oxaloacetate decarboxylase; Provisional; Region: PRK12331
351627005417	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
351627005418	active site
351627005419	catalytic residues [active]
351627005420	metal binding site [ion binding]; metal-binding site
351627005421	homodimer binding site [polypeptide binding]; other site
351627005422	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
351627005423	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
351627005424	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
351627005425	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
351627005426	putative active site [active]
351627005427	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
351627005428	catalytic core [active]
351627005429	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
351627005430	hexamer interface [polypeptide binding]; other site
351627005431	RNA binding site [nucleotide binding]; other site
351627005432	Histidine-zinc binding site [chemical binding]; other site
351627005433	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
351627005434	homotrimer interaction site [polypeptide binding]; other site
351627005435	active site
351627005436	cytidylate kinase; Provisional; Region: cmk; PRK00023
351627005437	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
351627005438	CMP-binding site; other site
351627005439	The sites determining sugar specificity; other site
351627005440	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
351627005441	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
351627005442	putative acyl-acceptor binding pocket; other site
351627005443	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
351627005444	LytB protein; Region: LYTB; cl00507
351627005445	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
351627005446	RNA binding site [nucleotide binding]; other site
351627005447	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
351627005448	RNA binding site [nucleotide binding]; other site
351627005449	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
351627005450	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
351627005451	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
351627005452	Domain of unknown function DUF20; Region: UPF0118; pfam01594
351627005453	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
351627005454	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
351627005455	motif 1; other site
351627005456	active site
351627005457	motif 2; other site
351627005458	motif 3; other site
351627005459	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
351627005460	DHHA1 domain; Region: DHHA1; pfam02272
351627005461	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
351627005462	nucleotide binding site/active site [active]
351627005463	HIT family signature motif; other site
351627005464	catalytic residue [active]
351627005465	ATP-NAD kinase; Region: NAD_kinase; pfam01513
351627005466	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
351627005467	arginine repressor; Provisional; Region: argR; PRK00441
351627005468	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
351627005469	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
351627005470	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
351627005471	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
351627005472	Walker A/P-loop; other site
351627005473	ATP binding site [chemical binding]; other site
351627005474	Q-loop/lid; other site
351627005475	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
351627005476	ABC transporter signature motif; other site
351627005477	Walker B; other site
351627005478	D-loop; other site
351627005479	H-loop/switch region; other site
351627005480	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
351627005481	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
351627005482	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
351627005483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627005484	active site
351627005485	phosphorylation site [posttranslational modification]
351627005486	intermolecular recognition site; other site
351627005487	dimerization interface [polypeptide binding]; other site
351627005488	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
351627005489	stage V sporulation protein B; Region: spore_V_B; TIGR02900
351627005490	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
351627005491	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
351627005492	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
351627005493	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
351627005494	RNA/DNA hybrid binding site [nucleotide binding]; other site
351627005495	active site
351627005496	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
351627005497	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
351627005498	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
351627005499	dimer interface [polypeptide binding]; other site
351627005500	ADP-ribose binding site [chemical binding]; other site
351627005501	active site
351627005502	nudix motif; other site
351627005503	metal binding site [ion binding]; metal-binding site
351627005504	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
351627005505	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
351627005506	active site
351627005507	PHP-associated; Region: PHP_C; pfam13263
351627005508	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
351627005509	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
351627005510	catalytic residue [active]
351627005511	Protein of unknown function (DUF552); Region: DUF552; pfam04472
351627005512	YGGT family; Region: YGGT; pfam02325
351627005513	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
351627005514	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351627005515	RNA binding surface [nucleotide binding]; other site
351627005516	DivIVA protein; Region: DivIVA; pfam05103
351627005517	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
351627005518	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
351627005519	HIGH motif; other site
351627005520	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
351627005521	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
351627005522	active site
351627005523	KMSKS motif; other site
351627005524	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
351627005525	tRNA binding surface [nucleotide binding]; other site
351627005526	anticodon binding site; other site
351627005527	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
351627005528	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
351627005529	active site
351627005530	dimer interface [polypeptide binding]; other site
351627005531	metal binding site [ion binding]; metal-binding site
351627005532	Penicillinase repressor; Region: Pencillinase_R; cl17580
351627005533	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
351627005534	SnoaL-like domain; Region: SnoaL_4; cl17707
351627005535	Putative amidase domain; Region: Amidase_6; pfam12671
351627005536	Putative amidase domain; Region: Amidase_6; pfam12671
351627005537	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
351627005538	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
351627005539	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
351627005540	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
351627005541	lipoprotein signal peptidase; Provisional; Region: PRK14791
351627005542	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
351627005543	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351627005544	RNA binding surface [nucleotide binding]; other site
351627005545	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
351627005546	active site
351627005547	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
351627005548	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627005549	active site
351627005550	uracil transporter; Provisional; Region: PRK10720
351627005551	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
351627005552	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
351627005553	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
351627005554	dihydroorotase; Validated; Region: pyrC; PRK09357
351627005555	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
351627005556	active site
351627005557	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
351627005558	active site
351627005559	dimer interface [polypeptide binding]; other site
351627005560	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
351627005561	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
351627005562	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
351627005563	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
351627005564	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
351627005565	ATP-grasp domain; Region: ATP-grasp_4; cl17255
351627005566	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
351627005567	IMP binding site; other site
351627005568	dimer interface [polypeptide binding]; other site
351627005569	interdomain contacts; other site
351627005570	partial ornithine binding site; other site
351627005571	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
351627005572	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
351627005573	FAD binding pocket [chemical binding]; other site
351627005574	FAD binding motif [chemical binding]; other site
351627005575	phosphate binding motif [ion binding]; other site
351627005576	beta-alpha-beta structure motif; other site
351627005577	NAD binding pocket [chemical binding]; other site
351627005578	Iron coordination center [ion binding]; other site
351627005579	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
351627005580	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
351627005581	heterodimer interface [polypeptide binding]; other site
351627005582	active site
351627005583	FMN binding site [chemical binding]; other site
351627005584	homodimer interface [polypeptide binding]; other site
351627005585	substrate binding site [chemical binding]; other site
351627005586	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
351627005587	catalytic core [active]
351627005588	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627005589	active site
351627005590	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
351627005591	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
351627005592	Walker A/P-loop; other site
351627005593	ATP binding site [chemical binding]; other site
351627005594	Q-loop/lid; other site
351627005595	ABC transporter signature motif; other site
351627005596	Walker B; other site
351627005597	D-loop; other site
351627005598	H-loop/switch region; other site
351627005599	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
351627005600	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
351627005601	Walker A/P-loop; other site
351627005602	ATP binding site [chemical binding]; other site
351627005603	Q-loop/lid; other site
351627005604	ABC transporter signature motif; other site
351627005605	Walker B; other site
351627005606	D-loop; other site
351627005607	H-loop/switch region; other site
351627005608	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
351627005609	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
351627005610	TM-ABC transporter signature motif; other site
351627005611	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351627005612	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
351627005613	TM-ABC transporter signature motif; other site
351627005614	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
351627005615	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
351627005616	putative ligand binding site [chemical binding]; other site
351627005617	Uncharacterized conserved protein [Function unknown]; Region: COG1751
351627005618	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
351627005619	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
351627005620	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351627005621	active site
351627005622	DNA binding site [nucleotide binding]
351627005623	Int/Topo IB signature motif; other site
351627005624	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351627005625	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
351627005626	putative active site [active]
351627005627	Glucuronate isomerase; Region: UxaC; pfam02614
351627005628	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
351627005629	enolase; Provisional; Region: eno; PRK00077
351627005630	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
351627005631	dimer interface [polypeptide binding]; other site
351627005632	metal binding site [ion binding]; metal-binding site
351627005633	substrate binding pocket [chemical binding]; other site
351627005634	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
351627005635	phosphoglyceromutase; Provisional; Region: PRK05434
351627005636	bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962
351627005637	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
351627005638	substrate binding site [chemical binding]; other site
351627005639	hinge regions; other site
351627005640	ADP binding site [chemical binding]; other site
351627005641	catalytic site [active]
351627005642	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
351627005643	substrate binding site [chemical binding]; other site
351627005644	dimer interface [polypeptide binding]; other site
351627005645	catalytic triad [active]
351627005646	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
351627005647	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
351627005648	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
351627005649	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
351627005650	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
351627005651	pyruvate phosphate dikinase; Provisional; Region: PRK09279
351627005652	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
351627005653	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
351627005654	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
351627005655	glycyl-tRNA synthetase; Provisional; Region: PRK04173
351627005656	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
351627005657	dimer interface [polypeptide binding]; other site
351627005658	motif 1; other site
351627005659	active site
351627005660	motif 2; other site
351627005661	motif 3; other site
351627005662	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
351627005663	anticodon binding site; other site
351627005664	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
351627005665	Recombination protein O N terminal; Region: RecO_N; pfam11967
351627005666	Recombination protein O C terminal; Region: RecO_C; pfam02565
351627005667	GTPase Era; Reviewed; Region: era; PRK00089
351627005668	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
351627005669	G1 box; other site
351627005670	GTP/Mg2+ binding site [chemical binding]; other site
351627005671	Switch I region; other site
351627005672	G2 box; other site
351627005673	Switch II region; other site
351627005674	G3 box; other site
351627005675	G4 box; other site
351627005676	G5 box; other site
351627005677	KH domain; Region: KH_2; pfam07650
351627005678	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
351627005679	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
351627005680	active site
351627005681	hypothetical protein; Validated; Region: PRK07682
351627005682	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351627005683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627005684	homodimer interface [polypeptide binding]; other site
351627005685	catalytic residue [active]
351627005686	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
351627005687	AsnC family; Region: AsnC_trans_reg; pfam01037
351627005688	DivIVA protein; Region: DivIVA; pfam05103
351627005689	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
351627005690	trimer interface [polypeptide binding]; other site
351627005691	active site
351627005692	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
351627005693	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
351627005694	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
351627005695	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
351627005696	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
351627005697	HSP70 interaction site [polypeptide binding]; other site
351627005698	Tetratricopeptide repeat; Region: TPR_16; pfam13432
351627005699	Cauliflower mosaic virus peptidase (A3); Region: Peptidase_A3; pfam02160
351627005700	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
351627005701	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
351627005702	gamma subunit interface [polypeptide binding]; other site
351627005703	epsilon subunit interface [polypeptide binding]; other site
351627005704	LBP interface [polypeptide binding]; other site
351627005705	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
351627005706	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
351627005707	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
351627005708	alpha subunit interaction interface [polypeptide binding]; other site
351627005709	Walker A motif; other site
351627005710	ATP binding site [chemical binding]; other site
351627005711	Walker B motif; other site
351627005712	inhibitor binding site; inhibition site
351627005713	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
351627005714	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
351627005715	core domain interface [polypeptide binding]; other site
351627005716	delta subunit interface [polypeptide binding]; other site
351627005717	epsilon subunit interface [polypeptide binding]; other site
351627005718	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
351627005719	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
351627005720	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
351627005721	beta subunit interaction interface [polypeptide binding]; other site
351627005722	Walker A motif; other site
351627005723	ATP binding site [chemical binding]; other site
351627005724	Walker B motif; other site
351627005725	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
351627005726	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
351627005727	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
351627005728	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
351627005729	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
351627005730	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
351627005731	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
351627005732	GMP synthase; Reviewed; Region: guaA; PRK00074
351627005733	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
351627005734	AMP/PPi binding site [chemical binding]; other site
351627005735	candidate oxyanion hole; other site
351627005736	catalytic triad [active]
351627005737	potential glutamine specificity residues [chemical binding]; other site
351627005738	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
351627005739	ATP Binding subdomain [chemical binding]; other site
351627005740	Ligand Binding sites [chemical binding]; other site
351627005741	Dimerization subdomain; other site
351627005742	Predicted permeases [General function prediction only]; Region: COG0679
351627005743	Transposase domain (DUF772); Region: DUF772; pfam05598
351627005744	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627005745	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627005746	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
351627005747	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
351627005748	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
351627005749	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
351627005750	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351627005751	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
351627005752	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
351627005753	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
351627005754	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
351627005755	excinuclease ABC subunit B; Provisional; Region: PRK05298
351627005756	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351627005757	ATP binding site [chemical binding]; other site
351627005758	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351627005759	nucleotide binding region [chemical binding]; other site
351627005760	ATP-binding site [chemical binding]; other site
351627005761	Ultra-violet resistance protein B; Region: UvrB; pfam12344
351627005762	UvrB/uvrC motif; Region: UVR; pfam02151
351627005763	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
351627005764	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351627005765	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351627005766	catalytic residue [active]
351627005767	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
351627005768	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
351627005769	CoA-binding site [chemical binding]; other site
351627005770	ATP-binding [chemical binding]; other site
351627005771	DNA polymerase I; Provisional; Region: PRK05755
351627005772	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
351627005773	active site
351627005774	metal binding site 1 [ion binding]; metal-binding site
351627005775	putative 5' ssDNA interaction site; other site
351627005776	metal binding site 3; metal-binding site
351627005777	metal binding site 2 [ion binding]; metal-binding site
351627005778	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
351627005779	putative DNA binding site [nucleotide binding]; other site
351627005780	putative metal binding site [ion binding]; other site
351627005781	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
351627005782	substrate binding site [chemical binding]; other site
351627005783	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
351627005784	active site
351627005785	DNA binding site [nucleotide binding]
351627005786	catalytic site [active]
351627005787	Rubredoxin; Region: Rubredoxin; pfam00301
351627005788	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
351627005789	iron binding site [ion binding]; other site
351627005790	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
351627005791	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
351627005792	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
351627005793	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
351627005794	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
351627005795	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
351627005796	purine monophosphate binding site [chemical binding]; other site
351627005797	dimer interface [polypeptide binding]; other site
351627005798	putative catalytic residues [active]
351627005799	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
351627005800	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
351627005801	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
351627005802	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
351627005803	active site
351627005804	substrate binding site [chemical binding]; other site
351627005805	cosubstrate binding site; other site
351627005806	catalytic site [active]
351627005807	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
351627005808	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
351627005809	dimerization interface [polypeptide binding]; other site
351627005810	putative ATP binding site [chemical binding]; other site
351627005811	amidophosphoribosyltransferase; Provisional; Region: PRK05793
351627005812	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
351627005813	active site
351627005814	tetramer interface [polypeptide binding]; other site
351627005815	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
351627005816	active site
351627005817	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
351627005818	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
351627005819	dimerization interface [polypeptide binding]; other site
351627005820	ATP binding site [chemical binding]; other site
351627005821	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
351627005822	dimerization interface [polypeptide binding]; other site
351627005823	ATP binding site [chemical binding]; other site
351627005824	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
351627005825	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
351627005826	putative active site [active]
351627005827	catalytic triad [active]
351627005828	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
351627005829	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
351627005830	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
351627005831	ATP binding site [chemical binding]; other site
351627005832	active site
351627005833	substrate binding site [chemical binding]; other site
351627005834	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
351627005835	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
351627005836	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
351627005837	LrgA family; Region: LrgA; cl00608
351627005838	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
351627005839	protein binding site [polypeptide binding]; other site
351627005840	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
351627005841	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627005842	dimerization interface [polypeptide binding]; other site
351627005843	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351627005844	dimer interface [polypeptide binding]; other site
351627005845	phosphorylation site [posttranslational modification]
351627005846	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627005847	ATP binding site [chemical binding]; other site
351627005848	Mg2+ binding site [ion binding]; other site
351627005849	G-X-G motif; other site
351627005850	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351627005851	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627005852	active site
351627005853	phosphorylation site [posttranslational modification]
351627005854	intermolecular recognition site; other site
351627005855	dimerization interface [polypeptide binding]; other site
351627005856	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351627005857	DNA binding site [nucleotide binding]
351627005858	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
351627005859	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
351627005860	dimerization interface [polypeptide binding]; other site
351627005861	putative ATP binding site [chemical binding]; other site
351627005862	Membrane protein of unknown function; Region: DUF360; pfam04020
351627005863	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
351627005864	single-stranded DNA-binding protein; Provisional; Region: PRK05813
351627005865	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
351627005866	dimer interface [polypeptide binding]; other site
351627005867	ssDNA binding site [nucleotide binding]; other site
351627005868	tetramer (dimer of dimers) interface [polypeptide binding]; other site
351627005869	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
351627005870	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
351627005871	NodB motif; other site
351627005872	active site
351627005873	catalytic site [active]
351627005874	metal binding site [ion binding]; metal-binding site
351627005875	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
351627005876	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
351627005877	putative ATP binding site [chemical binding]; other site
351627005878	putative substrate interface [chemical binding]; other site
351627005879	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
351627005880	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
351627005881	nucleotide binding site [chemical binding]; other site
351627005882	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
351627005883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
351627005884	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
351627005885	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
351627005886	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
351627005887	helix-hairpin-helix signature motif; other site
351627005888	substrate binding pocket [chemical binding]; other site
351627005889	active site
351627005890	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
351627005891	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
351627005892	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351627005893	Coenzyme A binding pocket [chemical binding]; other site
351627005894	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
351627005895	MviN-like protein; Region: MVIN; pfam03023
351627005896	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
351627005897	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
351627005898	Substrate binding site; other site
351627005899	Cupin domain; Region: Cupin_2; cl17218
351627005900	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
351627005901	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
351627005902	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
351627005903	metal binding site [ion binding]; metal-binding site
351627005904	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
351627005905	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
351627005906	substrate binding site [chemical binding]; other site
351627005907	glutamase interaction surface [polypeptide binding]; other site
351627005908	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
351627005909	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
351627005910	catalytic residues [active]
351627005911	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
351627005912	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
351627005913	putative active site [active]
351627005914	oxyanion strand; other site
351627005915	catalytic triad [active]
351627005916	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
351627005917	putative active site pocket [active]
351627005918	4-fold oligomerization interface [polypeptide binding]; other site
351627005919	metal binding residues [ion binding]; metal-binding site
351627005920	3-fold/trimer interface [polypeptide binding]; other site
351627005921	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
351627005922	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351627005923	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627005924	homodimer interface [polypeptide binding]; other site
351627005925	catalytic residue [active]
351627005926	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
351627005927	histidinol dehydrogenase; Region: hisD; TIGR00069
351627005928	NAD binding site [chemical binding]; other site
351627005929	dimerization interface [polypeptide binding]; other site
351627005930	product binding site; other site
351627005931	substrate binding site [chemical binding]; other site
351627005932	zinc binding site [ion binding]; other site
351627005933	catalytic residues [active]
351627005934	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
351627005935	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
351627005936	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
351627005937	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
351627005938	dimer interface [polypeptide binding]; other site
351627005939	motif 1; other site
351627005940	active site
351627005941	motif 2; other site
351627005942	motif 3; other site
351627005943	QueT transporter; Region: QueT; pfam06177
351627005944	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
351627005945	PhoU domain; Region: PhoU; pfam01895
351627005946	PhoU domain; Region: PhoU; pfam01895
351627005947	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
351627005948	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
351627005949	Walker A/P-loop; other site
351627005950	ATP binding site [chemical binding]; other site
351627005951	Q-loop/lid; other site
351627005952	ABC transporter signature motif; other site
351627005953	Walker B; other site
351627005954	D-loop; other site
351627005955	H-loop/switch region; other site
351627005956	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
351627005957	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
351627005958	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
351627005959	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351627005960	dimer interface [polypeptide binding]; other site
351627005961	phosphorylation site [posttranslational modification]
351627005962	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627005963	ATP binding site [chemical binding]; other site
351627005964	Mg2+ binding site [ion binding]; other site
351627005965	G-X-G motif; other site
351627005966	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351627005967	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627005968	active site
351627005969	phosphorylation site [posttranslational modification]
351627005970	intermolecular recognition site; other site
351627005971	dimerization interface [polypeptide binding]; other site
351627005972	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351627005973	DNA binding site [nucleotide binding]
351627005974	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
351627005975	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
351627005976	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
351627005977	active site
351627005978	intersubunit interactions; other site
351627005979	catalytic residue [active]
351627005980	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
351627005981	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351627005982	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
351627005983	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
351627005984	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
351627005985	HIGH motif; other site
351627005986	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
351627005987	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
351627005988	active site
351627005989	KMSKS motif; other site
351627005990	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
351627005991	tRNA binding surface [nucleotide binding]; other site
351627005992	anticodon binding site; other site
351627005993	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
351627005994	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
351627005995	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
351627005996	non-heme iron binding site [ion binding]; other site
351627005997	dimer interface [polypeptide binding]; other site
351627005998	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
351627005999	non-heme iron binding site [ion binding]; other site
351627006000	dimer interface [polypeptide binding]; other site
351627006001	propionate/acetate kinase; Provisional; Region: PRK12379
351627006002	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
351627006003	nucleotide binding site [chemical binding]; other site
351627006004	butyrate kinase; Provisional; Region: PRK03011
351627006005	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
351627006006	LexA repressor; Validated; Region: PRK00215
351627006007	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
351627006008	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
351627006009	Catalytic site [active]
351627006010	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
351627006011	Aluminium resistance protein; Region: Alum_res; pfam06838
351627006012	bacterial Hfq-like; Region: Hfq; cd01716
351627006013	Sm1 motif; other site
351627006014	RNA binding site [nucleotide binding]; other site
351627006015	hexamer interface [polypeptide binding]; other site
351627006016	Sm2 motif; other site
351627006017	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
351627006018	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
351627006019	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
351627006020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
351627006021	ATP binding site [chemical binding]; other site
351627006022	Mg2+ binding site [ion binding]; other site
351627006023	G-X-G motif; other site
351627006024	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
351627006025	ATP binding site [chemical binding]; other site
351627006026	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
351627006027	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
351627006028	MutS domain I; Region: MutS_I; pfam01624
351627006029	MutS domain II; Region: MutS_II; pfam05188
351627006030	MutS domain III; Region: MutS_III; pfam05192
351627006031	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
351627006032	Walker A/P-loop; other site
351627006033	ATP binding site [chemical binding]; other site
351627006034	Q-loop/lid; other site
351627006035	ABC transporter signature motif; other site
351627006036	Walker B; other site
351627006037	D-loop; other site
351627006038	H-loop/switch region; other site
351627006039	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
351627006040	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
351627006041	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627006042	FeS/SAM binding site; other site
351627006043	TRAM domain; Region: TRAM; pfam01938
351627006044	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
351627006045	ACT domain-containing protein [General function prediction only]; Region: COG4747
351627006046	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
351627006047	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
351627006048	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
351627006049	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351627006050	acyl-activating enzyme (AAE) consensus motif; other site
351627006051	AMP binding site [chemical binding]; other site
351627006052	active site
351627006053	CoA binding site [chemical binding]; other site
351627006054	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
351627006055	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
351627006056	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
351627006057	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
351627006058	dimer interface [polypeptide binding]; other site
351627006059	PYR/PP interface [polypeptide binding]; other site
351627006060	TPP binding site [chemical binding]; other site
351627006061	substrate binding site [chemical binding]; other site
351627006062	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
351627006063	TPP-binding site; other site
351627006064	4Fe-4S binding domain; Region: Fer4; pfam00037
351627006065	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
351627006066	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351627006067	acyl-activating enzyme (AAE) consensus motif; other site
351627006068	AMP binding site [chemical binding]; other site
351627006069	active site
351627006070	CoA binding site [chemical binding]; other site
351627006071	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
351627006072	Clp amino terminal domain; Region: Clp_N; pfam02861
351627006073	Clp amino terminal domain; Region: Clp_N; pfam02861
351627006074	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627006075	Walker A motif; other site
351627006076	ATP binding site [chemical binding]; other site
351627006077	Walker B motif; other site
351627006078	arginine finger; other site
351627006079	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627006080	Walker A motif; other site
351627006081	ATP binding site [chemical binding]; other site
351627006082	Walker B motif; other site
351627006083	arginine finger; other site
351627006084	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
351627006085	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
351627006086	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
351627006087	putative dimer interface [polypeptide binding]; other site
351627006088	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
351627006089	ATP cone domain; Region: ATP-cone; pfam03477
351627006090	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
351627006091	GAF domain; Region: GAF_3; pfam13492
351627006092	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351627006093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351627006094	metal binding site [ion binding]; metal-binding site
351627006095	active site
351627006096	I-site; other site
351627006097	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
351627006098	Malic enzyme, N-terminal domain; Region: malic; pfam00390
351627006099	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
351627006100	putative NAD(P) binding site [chemical binding]; other site
351627006101	recombination factor protein RarA; Reviewed; Region: PRK13342
351627006102	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627006103	Walker A motif; other site
351627006104	ATP binding site [chemical binding]; other site
351627006105	Walker B motif; other site
351627006106	arginine finger; other site
351627006107	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
351627006108	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
351627006109	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
351627006110	dimer interface [polypeptide binding]; other site
351627006111	active site
351627006112	glycine-pyridoxal phosphate binding site [chemical binding]; other site
351627006113	folate binding site [chemical binding]; other site
351627006114	Uncharacterized conserved protein [Function unknown]; Region: COG2966
351627006115	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
351627006116	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
351627006117	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
351627006118	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
351627006119	RNase E interface [polypeptide binding]; other site
351627006120	trimer interface [polypeptide binding]; other site
351627006121	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
351627006122	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
351627006123	RNase E interface [polypeptide binding]; other site
351627006124	trimer interface [polypeptide binding]; other site
351627006125	active site
351627006126	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
351627006127	putative nucleic acid binding region [nucleotide binding]; other site
351627006128	G-X-X-G motif; other site
351627006129	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
351627006130	RNA binding site [nucleotide binding]; other site
351627006131	domain interface; other site
351627006132	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
351627006133	16S/18S rRNA binding site [nucleotide binding]; other site
351627006134	S13e-L30e interaction site [polypeptide binding]; other site
351627006135	25S rRNA binding site [nucleotide binding]; other site
351627006136	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
351627006137	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
351627006138	active site
351627006139	Riboflavin kinase; Region: Flavokinase; pfam01687
351627006140	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
351627006141	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
351627006142	RNA binding site [nucleotide binding]; other site
351627006143	active site
351627006144	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
351627006145	DHH family; Region: DHH; pfam01368
351627006146	DHHA1 domain; Region: DHHA1; pfam02272
351627006147	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
351627006148	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
351627006149	translation initiation factor IF-2; Region: IF-2; TIGR00487
351627006150	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
351627006151	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
351627006152	G1 box; other site
351627006153	putative GEF interaction site [polypeptide binding]; other site
351627006154	GTP/Mg2+ binding site [chemical binding]; other site
351627006155	Switch I region; other site
351627006156	G2 box; other site
351627006157	G3 box; other site
351627006158	Switch II region; other site
351627006159	G4 box; other site
351627006160	G5 box; other site
351627006161	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
351627006162	Translation-initiation factor 2; Region: IF-2; pfam11987
351627006163	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
351627006164	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
351627006165	putative RNA binding cleft [nucleotide binding]; other site
351627006166	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
351627006167	NusA N-terminal domain; Region: NusA_N; pfam08529
351627006168	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
351627006169	RNA binding site [nucleotide binding]; other site
351627006170	homodimer interface [polypeptide binding]; other site
351627006171	NusA-like KH domain; Region: KH_5; pfam13184
351627006172	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
351627006173	G-X-X-G motif; other site
351627006174	ribosome maturation protein RimP; Reviewed; Region: PRK00092
351627006175	Sm and related proteins; Region: Sm_like; cl00259
351627006176	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
351627006177	putative oligomer interface [polypeptide binding]; other site
351627006178	putative RNA binding site [nucleotide binding]; other site
351627006179	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
351627006180	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
351627006181	substrate binding site [chemical binding]; other site
351627006182	hexamer interface [polypeptide binding]; other site
351627006183	metal binding site [ion binding]; metal-binding site
351627006184	GTPase RsgA; Reviewed; Region: PRK00098
351627006185	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
351627006186	RNA binding site [nucleotide binding]; other site
351627006187	homodimer interface [polypeptide binding]; other site
351627006188	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
351627006189	GTPase/Zn-binding domain interface [polypeptide binding]; other site
351627006190	GTP/Mg2+ binding site [chemical binding]; other site
351627006191	G4 box; other site
351627006192	G5 box; other site
351627006193	G1 box; other site
351627006194	Switch I region; other site
351627006195	G2 box; other site
351627006196	G3 box; other site
351627006197	Switch II region; other site
351627006198	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
351627006199	Catalytic domain of Protein Kinases; Region: PKc; cd00180
351627006200	active site
351627006201	ATP binding site [chemical binding]; other site
351627006202	substrate binding site [chemical binding]; other site
351627006203	activation loop (A-loop); other site
351627006204	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
351627006205	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
351627006206	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
351627006207	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
351627006208	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
351627006209	Protein phosphatase 2C; Region: PP2C; pfam00481
351627006210	active site
351627006211	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
351627006212	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627006213	FeS/SAM binding site; other site
351627006214	16S rRNA methyltransferase B; Provisional; Region: PRK14902
351627006215	NusB family; Region: NusB; pfam01029
351627006216	putative RNA binding site [nucleotide binding]; other site
351627006217	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627006218	S-adenosylmethionine binding site [chemical binding]; other site
351627006219	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
351627006220	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
351627006221	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
351627006222	putative active site [active]
351627006223	substrate binding site [chemical binding]; other site
351627006224	putative cosubstrate binding site; other site
351627006225	catalytic site [active]
351627006226	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
351627006227	substrate binding site [chemical binding]; other site
351627006228	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
351627006229	active site
351627006230	catalytic residues [active]
351627006231	metal binding site [ion binding]; metal-binding site
351627006232	primosome assembly protein PriA; Validated; Region: PRK05580
351627006233	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351627006234	ATP binding site [chemical binding]; other site
351627006235	putative Mg++ binding site [ion binding]; other site
351627006236	helicase superfamily c-terminal domain; Region: HELICc; smart00490
351627006237	nucleotide binding region [chemical binding]; other site
351627006238	ATP-binding site [chemical binding]; other site
351627006239	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
351627006240	Flavoprotein; Region: Flavoprotein; pfam02441
351627006241	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
351627006242	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
351627006243	Guanylate kinase; Region: Guanylate_kin; pfam00625
351627006244	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
351627006245	catalytic site [active]
351627006246	G-X2-G-X-G-K; other site
351627006247	hypothetical protein; Provisional; Region: PRK04323
351627006248	hypothetical protein; Provisional; Region: PRK11820
351627006249	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
351627006250	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
351627006251	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
351627006252	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
351627006253	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
351627006254	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
351627006255	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
351627006256	active site
351627006257	Zn binding site [ion binding]; other site
351627006258	Protein of unknown function DUF89; Region: DUF89; cl15397
351627006259	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
351627006260	putative active site [active]
351627006261	Transposase domain (DUF772); Region: DUF772; pfam05598
351627006262	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627006263	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627006264	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351627006265	non-specific DNA binding site [nucleotide binding]; other site
351627006266	salt bridge; other site
351627006267	sequence-specific DNA binding site [nucleotide binding]; other site
351627006268	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
351627006269	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
351627006270	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
351627006271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627006272	Walker A motif; other site
351627006273	ATP binding site [chemical binding]; other site
351627006274	Walker B motif; other site
351627006275	arginine finger; other site
351627006276	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627006277	Integrase core domain; Region: rve; pfam00665
351627006278	YcfA-like protein; Region: YcfA; pfam07927
351627006279	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
351627006280	CoA binding domain; Region: CoA_binding_2; pfam13380
351627006281	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
351627006282	Predicted membrane protein [Function unknown]; Region: COG2323
351627006283	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
351627006284	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
351627006285	acyl-activating enzyme (AAE) consensus motif; other site
351627006286	AMP binding site [chemical binding]; other site
351627006287	active site
351627006288	CoA binding site [chemical binding]; other site
351627006289	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
351627006290	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
351627006291	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
351627006292	dimer interface [polypeptide binding]; other site
351627006293	PYR/PP interface [polypeptide binding]; other site
351627006294	TPP binding site [chemical binding]; other site
351627006295	substrate binding site [chemical binding]; other site
351627006296	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
351627006297	TPP-binding site; other site
351627006298	4Fe-4S binding domain; Region: Fer4; pfam00037
351627006299	stage V sporulation protein T; Region: spore_V_T; TIGR02851
351627006300	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
351627006301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627006302	Major Facilitator Superfamily; Region: MFS_1; pfam07690
351627006303	putative substrate translocation pore; other site
351627006304	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
351627006305	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
351627006306	substrate binding pocket [chemical binding]; other site
351627006307	chain length determination region; other site
351627006308	substrate-Mg2+ binding site; other site
351627006309	catalytic residues [active]
351627006310	aspartate-rich region 1; other site
351627006311	active site lid residues [active]
351627006312	aspartate-rich region 2; other site
351627006313	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
351627006314	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
351627006315	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
351627006316	generic binding surface II; other site
351627006317	generic binding surface I; other site
351627006318	transcription antitermination factor NusB; Region: nusB; TIGR01951
351627006319	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
351627006320	Asp23 family; Region: Asp23; pfam03780
351627006321	Asp23 family; Region: Asp23; pfam03780
351627006322	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
351627006323	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
351627006324	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
351627006325	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
351627006326	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
351627006327	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548
351627006328	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
351627006329	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
351627006330	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
351627006331	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
351627006332	putative active site [active]
351627006333	metal binding site [ion binding]; metal-binding site
351627006334	homodimer binding site [polypeptide binding]; other site
351627006335	phosphodiesterase; Provisional; Region: PRK12704
351627006336	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
351627006337	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627006338	Zn2+ binding site [ion binding]; other site
351627006339	Mg2+ binding site [ion binding]; other site
351627006340	RecX family; Region: RecX; cl00936
351627006341	recombinase A; Provisional; Region: recA; PRK09354
351627006342	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
351627006343	hexamer interface [polypeptide binding]; other site
351627006344	Walker A motif; other site
351627006345	ATP binding site [chemical binding]; other site
351627006346	Walker B motif; other site
351627006347	competence damage-inducible protein A; Provisional; Region: PRK00549
351627006348	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
351627006349	putative MPT binding site; other site
351627006350	Competence-damaged protein; Region: CinA; pfam02464
351627006351	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
351627006352	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
351627006353	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
351627006354	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627006355	FeS/SAM binding site; other site
351627006356	TRAM domain; Region: TRAM; pfam01938
351627006357	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
351627006358	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
351627006359	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
351627006360	homodimer interface [polypeptide binding]; other site
351627006361	NADP binding site [chemical binding]; other site
351627006362	substrate binding site [chemical binding]; other site
351627006363	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
351627006364	hypothetical protein; Provisional; Region: PRK00955
351627006365	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
351627006366	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
351627006367	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
351627006368	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
351627006369	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
351627006370	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
351627006371	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
351627006372	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826
351627006373	hypothetical protein; Reviewed; Region: PRK12497
351627006374	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
351627006375	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
351627006376	RNA/DNA hybrid binding site [nucleotide binding]; other site
351627006377	active site
351627006378	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
351627006379	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
351627006380	GTP/Mg2+ binding site [chemical binding]; other site
351627006381	G4 box; other site
351627006382	G5 box; other site
351627006383	G1 box; other site
351627006384	Switch I region; other site
351627006385	G2 box; other site
351627006386	G3 box; other site
351627006387	Switch II region; other site
351627006388	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
351627006389	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
351627006390	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
351627006391	RimM N-terminal domain; Region: RimM; pfam01782
351627006392	PRC-barrel domain; Region: PRC; pfam05239
351627006393	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
351627006394	hypothetical protein; Provisional; Region: PRK00468
351627006395	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
351627006396	signal recognition particle protein; Provisional; Region: PRK10867
351627006397	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
351627006398	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
351627006399	P loop; other site
351627006400	GTP binding site [chemical binding]; other site
351627006401	Signal peptide binding domain; Region: SRP_SPB; pfam02978
351627006402	putative DNA-binding protein; Validated; Region: PRK00118
351627006403	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
351627006404	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627006405	Walker A/P-loop; other site
351627006406	ATP binding site [chemical binding]; other site
351627006407	Q-loop/lid; other site
351627006408	ABC transporter signature motif; other site
351627006409	Walker B; other site
351627006410	D-loop; other site
351627006411	H-loop/switch region; other site
351627006412	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
351627006413	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351627006414	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351627006415	DNA-binding site [nucleotide binding]; DNA binding site
351627006416	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627006417	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
351627006418	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
351627006419	HIGH motif; other site
351627006420	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
351627006421	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
351627006422	active site
351627006423	HIGH motif; other site
351627006424	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
351627006425	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627006426	Walker A/P-loop; other site
351627006427	ATP binding site [chemical binding]; other site
351627006428	Q-loop/lid; other site
351627006429	ABC transporter signature motif; other site
351627006430	Walker B; other site
351627006431	D-loop; other site
351627006432	H-loop/switch region; other site
351627006433	Transposase domain (DUF772); Region: DUF772; pfam05598
351627006434	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627006435	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627006436	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627006437	FeS/SAM binding site; other site
351627006438	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
351627006439	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
351627006440	HIGH motif; other site
351627006441	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
351627006442	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
351627006443	active site
351627006444	HIGH motif; other site
351627006445	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
351627006446	active site
351627006447	KMSKS motif; other site
351627006448	Integrase core domain; Region: rve; pfam00665
351627006449	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
351627006450	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
351627006451	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
351627006452	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627006453	Walker A/P-loop; other site
351627006454	ATP binding site [chemical binding]; other site
351627006455	Q-loop/lid; other site
351627006456	ABC transporter signature motif; other site
351627006457	Walker B; other site
351627006458	D-loop; other site
351627006459	H-loop/switch region; other site
351627006460	HlyD family secretion protein; Region: HlyD; pfam00529
351627006461	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
351627006462	HlyD family secretion protein; Region: HlyD_3; pfam13437
351627006463	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
351627006464	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
351627006465	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
351627006466	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
351627006467	putative FMN binding site [chemical binding]; other site
351627006468	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639
351627006469	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
351627006470	substrate binding site; other site
351627006471	dimer interface; other site
351627006472	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
351627006473	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
351627006474	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
351627006475	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
351627006476	active site residue [active]
351627006477	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
351627006478	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
351627006479	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
351627006480	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
351627006481	Soluble P-type ATPase [General function prediction only]; Region: COG4087
351627006482	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
351627006483	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627006484	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627006485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627006486	Walker A/P-loop; other site
351627006487	ATP binding site [chemical binding]; other site
351627006488	Q-loop/lid; other site
351627006489	ABC transporter signature motif; other site
351627006490	Walker B; other site
351627006491	D-loop; other site
351627006492	H-loop/switch region; other site
351627006493	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627006494	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627006495	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
351627006496	Walker A/P-loop; other site
351627006497	ATP binding site [chemical binding]; other site
351627006498	Q-loop/lid; other site
351627006499	ABC transporter signature motif; other site
351627006500	Walker B; other site
351627006501	D-loop; other site
351627006502	H-loop/switch region; other site
351627006503	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
351627006504	core dimer interface [polypeptide binding]; other site
351627006505	peripheral dimer interface [polypeptide binding]; other site
351627006506	L10 interface [polypeptide binding]; other site
351627006507	L11 interface [polypeptide binding]; other site
351627006508	putative EF-Tu interaction site [polypeptide binding]; other site
351627006509	putative EF-G interaction site [polypeptide binding]; other site
351627006510	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
351627006511	23S rRNA interface [nucleotide binding]; other site
351627006512	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
351627006513	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
351627006514	mRNA/rRNA interface [nucleotide binding]; other site
351627006515	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
351627006516	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
351627006517	23S rRNA interface [nucleotide binding]; other site
351627006518	L7/L12 interface [polypeptide binding]; other site
351627006519	putative thiostrepton binding site; other site
351627006520	L25 interface [polypeptide binding]; other site
351627006521	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
351627006522	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
351627006523	putative homodimer interface [polypeptide binding]; other site
351627006524	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
351627006525	heterodimer interface [polypeptide binding]; other site
351627006526	homodimer interface [polypeptide binding]; other site
351627006527	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
351627006528	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
351627006529	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351627006530	non-specific DNA binding site [nucleotide binding]; other site
351627006531	salt bridge; other site
351627006532	sequence-specific DNA binding site [nucleotide binding]; other site
351627006533	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627006534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627006535	MULE transposase domain; Region: MULE; pfam10551
351627006536	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627006537	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
351627006538	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351627006539	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
351627006540	Int/Topo IB signature motif; other site
351627006541	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
351627006542	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
351627006543	active site
351627006544	Transcriptional regulators [Transcription]; Region: FadR; COG2186
351627006545	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351627006546	DNA-binding site [nucleotide binding]; DNA binding site
351627006547	FCD domain; Region: FCD; pfam07729
351627006548	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
351627006549	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
351627006550	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
351627006551	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
351627006552	active site
351627006553	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
351627006554	dimer interface [polypeptide binding]; other site
351627006555	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
351627006556	Ligand Binding Site [chemical binding]; other site
351627006557	Molecular Tunnel; other site
351627006558	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
351627006559	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
351627006560	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
351627006561	catalytic site [active]
351627006562	subunit interface [polypeptide binding]; other site
351627006563	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
351627006564	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
351627006565	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
351627006566	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
351627006567	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
351627006568	ATP-grasp domain; Region: ATP-grasp_4; cl17255
351627006569	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
351627006570	substrate binding site [chemical binding]; other site
351627006571	ornithine carbamoyltransferase; Provisional; Region: PRK00779
351627006572	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
351627006573	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
351627006574	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
351627006575	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
351627006576	substrate binding site [chemical binding]; other site
351627006577	active site
351627006578	catalytic residues [active]
351627006579	heterodimer interface [polypeptide binding]; other site
351627006580	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
351627006581	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
351627006582	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627006583	catalytic residue [active]
351627006584	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
351627006585	active site
351627006586	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
351627006587	active site
351627006588	ribulose/triose binding site [chemical binding]; other site
351627006589	phosphate binding site [ion binding]; other site
351627006590	substrate (anthranilate) binding pocket [chemical binding]; other site
351627006591	product (indole) binding pocket [chemical binding]; other site
351627006592	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
351627006593	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
351627006594	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
351627006595	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
351627006596	Glutamine amidotransferase class-I; Region: GATase; pfam00117
351627006597	glutamine binding [chemical binding]; other site
351627006598	catalytic triad [active]
351627006599	anthranilate synthase component I, archaeal clade; Region: TrpE-arch; TIGR01820
351627006600	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
351627006601	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
351627006602	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
351627006603	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
351627006604	active site
351627006605	Dehydroquinase class II; Region: DHquinase_II; pfam01220
351627006606	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
351627006607	trimer interface [polypeptide binding]; other site
351627006608	active site
351627006609	dimer interface [polypeptide binding]; other site
351627006610	AP endonuclease family 2; Region: AP2Ec; smart00518
351627006611	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
351627006612	Metal-binding active site; metal-binding site
351627006613	AP (apurinic/apyrimidinic) site pocket; other site
351627006614	shikimate kinase; Reviewed; Region: aroK; PRK00131
351627006615	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
351627006616	ADP binding site [chemical binding]; other site
351627006617	magnesium binding site [ion binding]; other site
351627006618	putative shikimate binding site; other site
351627006619	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
351627006620	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
351627006621	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
351627006622	DNA binding residues [nucleotide binding]
351627006623	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
351627006624	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
351627006625	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627006626	Walker A/P-loop; other site
351627006627	ATP binding site [chemical binding]; other site
351627006628	Q-loop/lid; other site
351627006629	ABC transporter signature motif; other site
351627006630	Walker B; other site
351627006631	D-loop; other site
351627006632	H-loop/switch region; other site
351627006633	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
351627006634	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
351627006635	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
351627006636	dimer interface [polypeptide binding]; other site
351627006637	PYR/PP interface [polypeptide binding]; other site
351627006638	TPP binding site [chemical binding]; other site
351627006639	substrate binding site [chemical binding]; other site
351627006640	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
351627006641	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
351627006642	TPP-binding site [chemical binding]; other site
351627006643	putative dimer interface [polypeptide binding]; other site
351627006644	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
351627006645	pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028
351627006646	4Fe-4S binding domain; Region: Fer4_6; pfam12837
351627006647	4Fe-4S binding domain; Region: Fer4; pfam00037
351627006648	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
351627006649	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
351627006650	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
351627006651	active site
351627006652	NTP binding site [chemical binding]; other site
351627006653	metal binding triad [ion binding]; metal-binding site
351627006654	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
351627006655	histidinol-phosphatase; Provisional; Region: PRK05588
351627006656	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
351627006657	active site
351627006658	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
351627006659	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
351627006660	Ligand Binding Site [chemical binding]; other site
351627006661	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
351627006662	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
351627006663	trimerization site [polypeptide binding]; other site
351627006664	active site
351627006665	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
351627006666	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
351627006667	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
351627006668	catalytic residue [active]
351627006669	Transcriptional regulator; Region: Rrf2; cl17282
351627006670	Rrf2 family protein; Region: rrf2_super; TIGR00738
351627006671	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
351627006672	putative active site [active]
351627006673	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
351627006674	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
351627006675	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
351627006676	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
351627006677	alphaNTD homodimer interface [polypeptide binding]; other site
351627006678	alphaNTD - beta interaction site [polypeptide binding]; other site
351627006679	alphaNTD - beta' interaction site [polypeptide binding]; other site
351627006680	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
351627006681	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
351627006682	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
351627006683	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
351627006684	RNA binding surface [nucleotide binding]; other site
351627006685	30S ribosomal protein S11; Validated; Region: PRK05309
351627006686	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
351627006687	30S ribosomal protein S13; Region: bact_S13; TIGR03631
351627006688	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
351627006689	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
351627006690	rRNA binding site [nucleotide binding]; other site
351627006691	predicted 30S ribosome binding site; other site
351627006692	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
351627006693	RNA binding site [nucleotide binding]; other site
351627006694	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
351627006695	active site
351627006696	adenylate kinase; Reviewed; Region: adk; PRK00279
351627006697	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
351627006698	AMP-binding site [chemical binding]; other site
351627006699	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
351627006700	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
351627006701	SecY translocase; Region: SecY; pfam00344
351627006702	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
351627006703	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
351627006704	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
351627006705	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
351627006706	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
351627006707	23S rRNA interface [nucleotide binding]; other site
351627006708	5S rRNA interface [nucleotide binding]; other site
351627006709	L27 interface [polypeptide binding]; other site
351627006710	L5 interface [polypeptide binding]; other site
351627006711	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
351627006712	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
351627006713	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
351627006714	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
351627006715	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
351627006716	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
351627006717	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
351627006718	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
351627006719	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
351627006720	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
351627006721	RNA binding site [nucleotide binding]; other site
351627006722	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
351627006723	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
351627006724	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
351627006725	23S rRNA interface [nucleotide binding]; other site
351627006726	putative translocon interaction site; other site
351627006727	signal recognition particle (SRP54) interaction site; other site
351627006728	L23 interface [polypeptide binding]; other site
351627006729	trigger factor interaction site; other site
351627006730	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
351627006731	23S rRNA interface [nucleotide binding]; other site
351627006732	5S rRNA interface [nucleotide binding]; other site
351627006733	putative antibiotic binding site [chemical binding]; other site
351627006734	L25 interface [polypeptide binding]; other site
351627006735	L27 interface [polypeptide binding]; other site
351627006736	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
351627006737	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
351627006738	G-X-X-G motif; other site
351627006739	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
351627006740	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
351627006741	putative translocon binding site; other site
351627006742	protein-rRNA interface [nucleotide binding]; other site
351627006743	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
351627006744	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
351627006745	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
351627006746	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
351627006747	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
351627006748	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
351627006749	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
351627006750	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
351627006751	Integrase core domain; Region: rve; pfam00665
351627006752	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
351627006753	iron binding site [ion binding]; other site
351627006754	Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908
351627006755	Ferritin-like domain; Region: Ferritin; pfam00210
351627006756	dinuclear metal binding motif [ion binding]; other site
351627006757	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627006758	Zn2+ binding site [ion binding]; other site
351627006759	Mg2+ binding site [ion binding]; other site
351627006760	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
351627006761	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627006762	Zn2+ binding site [ion binding]; other site
351627006763	Mg2+ binding site [ion binding]; other site
351627006764	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351627006765	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627006766	dimerization interface [polypeptide binding]; other site
351627006767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351627006768	dimer interface [polypeptide binding]; other site
351627006769	phosphorylation site [posttranslational modification]
351627006770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627006771	ATP binding site [chemical binding]; other site
351627006772	Mg2+ binding site [ion binding]; other site
351627006773	G-X-G motif; other site
351627006774	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351627006775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627006776	active site
351627006777	phosphorylation site [posttranslational modification]
351627006778	intermolecular recognition site; other site
351627006779	dimerization interface [polypeptide binding]; other site
351627006780	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351627006781	DNA binding site [nucleotide binding]
351627006782	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
351627006783	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
351627006784	active site
351627006785	substrate binding site [chemical binding]; other site
351627006786	metal binding site [ion binding]; metal-binding site
351627006787	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
351627006788	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627006789	FeS/SAM binding site; other site
351627006790	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
351627006791	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
351627006792	H+ Antiporter protein; Region: 2A0121; TIGR00900
351627006793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
351627006794	putative substrate translocation pore; other site
351627006795	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
351627006796	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
351627006797	oligomer interface [polypeptide binding]; other site
351627006798	putative active site [active]
351627006799	metal binding site [ion binding]; metal-binding site
351627006800	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
351627006801	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
351627006802	B12 binding domain; Region: B12-binding; pfam02310
351627006803	B12 binding site [chemical binding]; other site
351627006804	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
351627006805	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627006806	FeS/SAM binding site; other site
351627006807	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
351627006808	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
351627006809	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
351627006810	CPxP  motif; other site
351627006811	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
351627006812	putative homodimer interface [polypeptide binding]; other site
351627006813	putative homotetramer interface [polypeptide binding]; other site
351627006814	putative allosteric switch controlling residues; other site
351627006815	putative metal binding site [ion binding]; other site
351627006816	putative homodimer-homodimer interface [polypeptide binding]; other site
351627006817	4Fe-4S binding domain; Region: Fer4; cl02805
351627006818	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
351627006819	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
351627006820	protein binding site [polypeptide binding]; other site
351627006821	Protein of unknown function DUF16; Region: DUF16; pfam01519
351627006822	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
351627006823	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
351627006824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
351627006825	Trp repressor protein; Region: Trp_repressor; cl17266
351627006826	YtxC-like family; Region: YtxC; pfam08812
351627006827	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
351627006828	purine nucleoside phosphorylase; Provisional; Region: PRK08202
351627006829	phosphopentomutase; Provisional; Region: PRK05362
351627006830	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
351627006831	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
351627006832	intersubunit interface [polypeptide binding]; other site
351627006833	active site
351627006834	catalytic residue [active]
351627006835	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
351627006836	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
351627006837	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
351627006838	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
351627006839	Protein of unknown function (DUF1427); Region: DUF1427; cl01771
351627006840	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
351627006841	active site
351627006842	catalytic motif [active]
351627006843	Zn binding site [ion binding]; other site
351627006844	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
351627006845	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351627006846	DNA-binding site [nucleotide binding]; DNA binding site
351627006847	UTRA domain; Region: UTRA; pfam07702
351627006848	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351627006849	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
351627006850	TM-ABC transporter signature motif; other site
351627006851	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351627006852	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
351627006853	TM-ABC transporter signature motif; other site
351627006854	Transposase domain (DUF772); Region: DUF772; pfam05598
351627006855	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
351627006856	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
351627006857	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
351627006858	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
351627006859	Walker A/P-loop; other site
351627006860	ATP binding site [chemical binding]; other site
351627006861	Q-loop/lid; other site
351627006862	ABC transporter signature motif; other site
351627006863	Walker B; other site
351627006864	D-loop; other site
351627006865	H-loop/switch region; other site
351627006866	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
351627006867	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
351627006868	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
351627006869	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
351627006870	ligand binding site [chemical binding]; other site
351627006871	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
351627006872	catalytic triad [active]
351627006873	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
351627006874	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
351627006875	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
351627006876	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
351627006877	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
351627006878	active site
351627006879	Int/Topo IB signature motif; other site
351627006880	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
351627006881	stage II sporulation protein P; Region: spore_II_P; TIGR02867
351627006882	germination protease; Provisional; Region: PRK12362
351627006883	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
351627006884	germination protein YpeB; Region: spore_YpeB; TIGR02889
351627006885	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
351627006886	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
351627006887	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
351627006888	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
351627006889	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
351627006890	Peptidase family M23; Region: Peptidase_M23; pfam01551
351627006891	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
351627006892	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
351627006893	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
351627006894	C-terminal peptidase (prc); Region: prc; TIGR00225
351627006895	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
351627006896	protein binding site [polypeptide binding]; other site
351627006897	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
351627006898	Catalytic dyad [active]
351627006899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
351627006900	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
351627006901	Peptidase family M23; Region: Peptidase_M23; pfam01551
351627006902	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
351627006903	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
351627006904	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
351627006905	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627006906	Walker A/P-loop; other site
351627006907	ATP binding site [chemical binding]; other site
351627006908	Q-loop/lid; other site
351627006909	ABC transporter signature motif; other site
351627006910	Walker B; other site
351627006911	D-loop; other site
351627006912	H-loop/switch region; other site
351627006913	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
351627006914	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
351627006915	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
351627006916	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
351627006917	Walker A/P-loop; other site
351627006918	ATP binding site [chemical binding]; other site
351627006919	Q-loop/lid; other site
351627006920	ABC transporter signature motif; other site
351627006921	Walker B; other site
351627006922	D-loop; other site
351627006923	H-loop/switch region; other site
351627006924	TOBE domain; Region: TOBE; pfam03459
351627006925	Predicted membrane protein [Function unknown]; Region: COG2261
351627006926	Thiamine pyrophosphokinase; Region: TPK; cd07995
351627006927	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
351627006928	active site
351627006929	dimerization interface [polypeptide binding]; other site
351627006930	thiamine binding site [chemical binding]; other site
351627006931	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
351627006932	DNA polymerase III PolC; Validated; Region: polC; PRK00448
351627006933	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
351627006934	generic binding surface II; other site
351627006935	generic binding surface I; other site
351627006936	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
351627006937	active site
351627006938	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
351627006939	active site
351627006940	catalytic site [active]
351627006941	substrate binding site [chemical binding]; other site
351627006942	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
351627006943	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
351627006944	Ligand binding site; other site
351627006945	Putative Catalytic site; other site
351627006946	DXD motif; other site
351627006947	GcpE protein; Region: GcpE; pfam04551
351627006948	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
351627006949	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
351627006950	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
351627006951	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
351627006952	active site
351627006953	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
351627006954	protein binding site [polypeptide binding]; other site
351627006955	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
351627006956	putative substrate binding region [chemical binding]; other site
351627006957	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
351627006958	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
351627006959	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
351627006960	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
351627006961	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
351627006962	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
351627006963	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
351627006964	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
351627006965	catalytic residue [active]
351627006966	putative FPP diphosphate  binding site; other site
351627006967	putative FPP binding hydrophobic cleft; other site
351627006968	dimer interface [polypeptide binding]; other site
351627006969	putative IPP diphosphate binding site; other site
351627006970	ribosome recycling factor; Reviewed; Region: frr; PRK00083
351627006971	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
351627006972	hinge region; other site
351627006973	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
351627006974	putative nucleotide binding site [chemical binding]; other site
351627006975	uridine monophosphate binding site [chemical binding]; other site
351627006976	homohexameric interface [polypeptide binding]; other site
351627006977	elongation factor Ts; Reviewed; Region: tsf; PRK12332
351627006978	UBA/TS-N domain; Region: UBA; pfam00627
351627006979	Elongation factor TS; Region: EF_TS; pfam00889
351627006980	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
351627006981	rRNA interaction site [nucleotide binding]; other site
351627006982	S8 interaction site; other site
351627006983	putative laminin-1 binding site; other site
351627006984	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
351627006985	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
351627006986	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
351627006987	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
351627006988	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
351627006989	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627006990	putative homodimer interface [polypeptide binding]; other site
351627006991	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
351627006992	O-Antigen ligase; Region: Wzy_C; cl04850
351627006993	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
351627006994	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
351627006995	Domain of unknown function (DUF814); Region: DUF814; pfam05670
351627006996	6-phosphofructokinase; Provisional; Region: PRK14072
351627006997	active site
351627006998	ADP/pyrophosphate binding site [chemical binding]; other site
351627006999	dimerization interface [polypeptide binding]; other site
351627007000	allosteric effector site; other site
351627007001	fructose-1,6-bisphosphate binding site; other site
351627007002	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
351627007003	Clp amino terminal domain; Region: Clp_N; pfam02861
351627007004	Clp amino terminal domain; Region: Clp_N; pfam02861
351627007005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627007006	Walker A motif; other site
351627007007	ATP binding site [chemical binding]; other site
351627007008	Walker B motif; other site
351627007009	arginine finger; other site
351627007010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627007011	Walker A motif; other site
351627007012	ATP binding site [chemical binding]; other site
351627007013	Walker B motif; other site
351627007014	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
351627007015	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
351627007016	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
351627007017	ADP binding site [chemical binding]; other site
351627007018	phosphagen binding site; other site
351627007019	substrate specificity loop; other site
351627007020	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
351627007021	UvrB/uvrC motif; Region: UVR; pfam02151
351627007022	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
351627007023	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
351627007024	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
351627007025	NodB motif; other site
351627007026	active site
351627007027	catalytic site [active]
351627007028	Zn binding site [ion binding]; other site
351627007029	Probable zinc-binding domain; Region: zf-trcl; pfam13451
351627007030	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
351627007031	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
351627007032	elongation factor G; Reviewed; Region: PRK12740
351627007033	G1 box; other site
351627007034	putative GEF interaction site [polypeptide binding]; other site
351627007035	GTP/Mg2+ binding site [chemical binding]; other site
351627007036	Switch I region; other site
351627007037	G2 box; other site
351627007038	G3 box; other site
351627007039	Switch II region; other site
351627007040	G4 box; other site
351627007041	G5 box; other site
351627007042	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
351627007043	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
351627007044	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
351627007045	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
351627007046	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627007047	Zn2+ binding site [ion binding]; other site
351627007048	Mg2+ binding site [ion binding]; other site
351627007049	UGMP family protein; Validated; Region: PRK09604
351627007050	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
351627007051	Bacitracin resistance protein BacA; Region: BacA; pfam02673
351627007052	Uncharacterized membrane protein [Function unknown]; Region: COG3949
351627007053	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
351627007054	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
351627007055	acetylornithine aminotransferase; Provisional; Region: PRK02627
351627007056	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
351627007057	inhibitor-cofactor binding pocket; inhibition site
351627007058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627007059	catalytic residue [active]
351627007060	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
351627007061	Fe-S cluster binding site [ion binding]; other site
351627007062	active site
351627007063	S-layer homology domain; Region: SLH; pfam00395
351627007064	S-layer homology domain; Region: SLH; pfam00395
351627007065	S-layer homology domain; Region: SLH; pfam00395
351627007066	GAF domain; Region: GAF; cl17456
351627007067	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
351627007068	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
351627007069	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
351627007070	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
351627007071	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
351627007072	metal binding site [ion binding]; metal-binding site
351627007073	active site
351627007074	I-site; other site
351627007075	Double zinc ribbon; Region: DZR; pfam12773
351627007076	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
351627007077	cyclase homology domain; Region: CHD; cd07302
351627007078	nucleotidyl binding site; other site
351627007079	metal binding site [ion binding]; metal-binding site
351627007080	dimer interface [polypeptide binding]; other site
351627007081	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627007082	Predicted ATPase [General function prediction only]; Region: COG3899
351627007083	Walker A motif; other site
351627007084	ATP binding site [chemical binding]; other site
351627007085	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351627007086	binding surface
351627007087	TPR motif; other site
351627007088	TPR repeat; Region: TPR_11; pfam13414
351627007089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
351627007090	binding surface
351627007091	TPR motif; other site
351627007092	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627007093	MULE transposase domain; Region: MULE; pfam10551
351627007094	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627007095	Walker A motif; other site
351627007096	ATP binding site [chemical binding]; other site
351627007097	Integrase core domain; Region: rve; pfam00665
351627007098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627007099	Integrase core domain; Region: rve; pfam00665
351627007100	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351627007101	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627007102	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627007103	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
351627007104	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
351627007105	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
351627007106	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
351627007107	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
351627007108	CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895
351627007109	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
351627007110	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
351627007111	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
351627007112	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
351627007113	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
351627007114	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
351627007115	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
351627007116	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
351627007117	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
351627007118	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
351627007119	G5 domain; Region: G5; pfam07501
351627007120	Peptidase family M23; Region: Peptidase_M23; pfam01551
351627007121	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
351627007122	Glycosyl hydrolase family 10; Region: Glyco_10; smart00633
351627007123	Putative esterase; Region: Esterase; pfam00756
351627007124	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
351627007125	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
351627007126	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
351627007127	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627007128	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627007129	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
351627007130	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
351627007131	active site
351627007132	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627007133	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
351627007134	substrate binding site [chemical binding]; other site
351627007135	active site
351627007136	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
351627007137	metal binding site [ion binding]; metal-binding site
351627007138	ligand binding site [chemical binding]; other site
351627007139	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627007140	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627007141	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627007142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007143	dimer interface [polypeptide binding]; other site
351627007144	conserved gate region; other site
351627007145	putative PBP binding loops; other site
351627007146	ABC-ATPase subunit interface; other site
351627007147	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627007148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
351627007149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007150	ABC-ATPase subunit interface; other site
351627007151	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351627007152	binding surface
351627007153	Tetratricopeptide repeat; Region: TPR_16; pfam13432
351627007154	TPR motif; other site
351627007155	Yip1 domain; Region: Yip1; pfam04893
351627007156	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627007157	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007158	dimer interface [polypeptide binding]; other site
351627007159	conserved gate region; other site
351627007160	putative PBP binding loops; other site
351627007161	ABC-ATPase subunit interface; other site
351627007162	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627007163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007164	dimer interface [polypeptide binding]; other site
351627007165	conserved gate region; other site
351627007166	putative PBP binding loops; other site
351627007167	ABC-ATPase subunit interface; other site
351627007168	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
351627007169	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
351627007170	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627007171	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627007172	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
351627007173	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
351627007174	Predicted methyltransferases [General function prediction only]; Region: COG0313
351627007175	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
351627007176	putative SAM binding site [chemical binding]; other site
351627007177	putative homodimer interface [polypeptide binding]; other site
351627007178	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
351627007179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627007180	S-adenosylmethionine binding site [chemical binding]; other site
351627007181	Response regulator receiver domain; Region: Response_reg; pfam00072
351627007182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627007183	active site
351627007184	phosphorylation site [posttranslational modification]
351627007185	intermolecular recognition site; other site
351627007186	dimerization interface [polypeptide binding]; other site
351627007187	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
351627007188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627007189	FeS/SAM binding site; other site
351627007190	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
351627007191	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
351627007192	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
351627007193	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
351627007194	active site
351627007195	membrane protein; Provisional; Region: PRK14404
351627007196	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
351627007197	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
351627007198	Ca binding site [ion binding]; other site
351627007199	active site
351627007200	catalytic site [active]
351627007201	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
351627007202	metal binding site 2 [ion binding]; metal-binding site
351627007203	putative DNA binding helix; other site
351627007204	metal binding site 1 [ion binding]; metal-binding site
351627007205	dimer interface [polypeptide binding]; other site
351627007206	structural Zn2+ binding site [ion binding]; other site
351627007207	Rubrerythrin [Energy production and conversion]; Region: COG1592
351627007208	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
351627007209	binuclear metal center [ion binding]; other site
351627007210	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
351627007211	iron binding site [ion binding]; other site
351627007212	Short C-terminal domain; Region: SHOCT; pfam09851
351627007213	CAAX protease self-immunity; Region: Abi; pfam02517
351627007214	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
351627007215	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627007216	Walker A/P-loop; other site
351627007217	ATP binding site [chemical binding]; other site
351627007218	Q-loop/lid; other site
351627007219	ABC transporter signature motif; other site
351627007220	Walker B; other site
351627007221	D-loop; other site
351627007222	H-loop/switch region; other site
351627007223	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
351627007224	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
351627007225	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
351627007226	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
351627007227	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
351627007228	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
351627007229	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
351627007230	dimerization domain swap beta strand [polypeptide binding]; other site
351627007231	regulatory protein interface [polypeptide binding]; other site
351627007232	active site
351627007233	regulatory phosphorylation site [posttranslational modification]; other site
351627007234	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
351627007235	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
351627007236	active site
351627007237	P-loop; other site
351627007238	phosphorylation site [posttranslational modification]
351627007239	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
351627007240	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
351627007241	active site
351627007242	phosphorylation site [posttranslational modification]
351627007243	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
351627007244	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
351627007245	putative substrate binding site [chemical binding]; other site
351627007246	putative ATP binding site [chemical binding]; other site
351627007247	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
351627007248	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351627007249	DNA-binding site [nucleotide binding]; DNA binding site
351627007250	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
351627007251	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
351627007252	S-layer homology domain; Region: SLH; pfam00395
351627007253	S-layer homology domain; Region: SLH; pfam00395
351627007254	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
351627007255	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
351627007256	FtsX-like permease family; Region: FtsX; pfam02687
351627007257	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
351627007258	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
351627007259	Walker A/P-loop; other site
351627007260	ATP binding site [chemical binding]; other site
351627007261	Q-loop/lid; other site
351627007262	ABC transporter signature motif; other site
351627007263	Walker B; other site
351627007264	D-loop; other site
351627007265	H-loop/switch region; other site
351627007266	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
351627007267	E3 interaction surface; other site
351627007268	lipoyl attachment site [posttranslational modification]; other site
351627007269	HlyD family secretion protein; Region: HlyD_3; pfam13437
351627007270	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
351627007271	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
351627007272	HlyD family secretion protein; Region: HlyD_3; pfam13437
351627007273	Homeobox associated leucine zipper; Region: HALZ; pfam02183
351627007274	NPCBM/NEW2 domain; Region: NPCBM; cl07060
351627007275	S-layer homology domain; Region: SLH; pfam00395
351627007276	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627007277	dimerization interface [polypeptide binding]; other site
351627007278	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351627007279	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627007280	dimer interface [polypeptide binding]; other site
351627007281	putative CheW interface [polypeptide binding]; other site
351627007282	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
351627007283	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
351627007284	putative ligand binding site [chemical binding]; other site
351627007285	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
351627007286	antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819
351627007287	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351627007288	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351627007289	non-specific DNA binding site [nucleotide binding]; other site
351627007290	salt bridge; other site
351627007291	sequence-specific DNA binding site [nucleotide binding]; other site
351627007292	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
351627007293	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
351627007294	active site
351627007295	catalytic residues [active]
351627007296	metal binding site [ion binding]; metal-binding site
351627007297	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
351627007298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007299	dimer interface [polypeptide binding]; other site
351627007300	conserved gate region; other site
351627007301	putative PBP binding loops; other site
351627007302	ABC-ATPase subunit interface; other site
351627007303	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
351627007304	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
351627007305	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
351627007306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
351627007307	Radical SAM superfamily; Region: Radical_SAM; pfam04055
351627007308	FeS/SAM binding site; other site
351627007309	Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967
351627007310	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
351627007311	Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia.  This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965
351627007312	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
351627007313	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
351627007314	Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967
351627007315	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
351627007316	Nitrogen regulatory protein P-II; Region: P-II; smart00938
351627007317	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
351627007318	Nitrogen regulatory protein P-II; Region: P-II; smart00938
351627007319	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
351627007320	nitrogenase iron protein; Region: nifH; TIGR01287
351627007321	Nucleotide-binding sites [chemical binding]; other site
351627007322	Walker A motif; other site
351627007323	Switch I region of nucleotide binding site; other site
351627007324	Fe4S4 binding sites [ion binding]; other site
351627007325	Switch II region of nucleotide binding site; other site
351627007326	urease subunit alpha; Reviewed; Region: ureC; PRK13207
351627007327	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
351627007328	subunit interactions [polypeptide binding]; other site
351627007329	active site
351627007330	flap region; other site
351627007331	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
351627007332	gamma-beta subunit interface [polypeptide binding]; other site
351627007333	alpha-beta subunit interface [polypeptide binding]; other site
351627007334	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627007335	MULE transposase domain; Region: MULE; pfam10551
351627007336	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
351627007337	alpha-gamma subunit interface [polypeptide binding]; other site
351627007338	beta-gamma subunit interface [polypeptide binding]; other site
351627007339	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
351627007340	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
351627007341	Walker A/P-loop; other site
351627007342	ATP binding site [chemical binding]; other site
351627007343	Q-loop/lid; other site
351627007344	ABC transporter signature motif; other site
351627007345	Walker B; other site
351627007346	D-loop; other site
351627007347	H-loop/switch region; other site
351627007348	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
351627007349	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
351627007350	Walker A/P-loop; other site
351627007351	ATP binding site [chemical binding]; other site
351627007352	Q-loop/lid; other site
351627007353	ABC transporter signature motif; other site
351627007354	Walker B; other site
351627007355	D-loop; other site
351627007356	H-loop/switch region; other site
351627007357	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
351627007358	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
351627007359	TM-ABC transporter signature motif; other site
351627007360	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351627007361	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
351627007362	TM-ABC transporter signature motif; other site
351627007363	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
351627007364	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
351627007365	putative ligand binding site [chemical binding]; other site
351627007366	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
351627007367	Nitrogen regulatory protein P-II; Region: P-II; smart00938
351627007368	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
351627007369	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
351627007370	Probable transposase; Region: OrfB_IS605; pfam01385
351627007371	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
351627007372	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351627007373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627007374	S-adenosylmethionine binding site [chemical binding]; other site
351627007375	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
351627007376	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
351627007377	carboxyltransferase (CT) interaction site; other site
351627007378	biotinylation site [posttranslational modification]; other site
351627007379	oxaloacetate decarboxylase; Provisional; Region: PRK12331
351627007380	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
351627007381	active site
351627007382	catalytic residues [active]
351627007383	metal binding site [ion binding]; metal-binding site
351627007384	homodimer binding site [polypeptide binding]; other site
351627007385	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627007386	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351627007387	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627007388	dimer interface [polypeptide binding]; other site
351627007389	putative CheW interface [polypeptide binding]; other site
351627007390	Cache domain; Region: Cache_1; pfam02743
351627007391	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627007392	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627007393	dimerization interface [polypeptide binding]; other site
351627007394	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
351627007395	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627007396	dimer interface [polypeptide binding]; other site
351627007397	putative CheW interface [polypeptide binding]; other site
351627007398	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627007399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007400	dimer interface [polypeptide binding]; other site
351627007401	conserved gate region; other site
351627007402	putative PBP binding loops; other site
351627007403	ABC-ATPase subunit interface; other site
351627007404	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
351627007405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007406	dimer interface [polypeptide binding]; other site
351627007407	conserved gate region; other site
351627007408	putative PBP binding loops; other site
351627007409	ABC-ATPase subunit interface; other site
351627007410	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627007411	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627007412	Transcriptional regulators [Transcription]; Region: PurR; COG1609
351627007413	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
351627007414	DNA binding site [nucleotide binding]
351627007415	domain linker motif; other site
351627007416	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
351627007417	dimerization interface [polypeptide binding]; other site
351627007418	ligand binding site [chemical binding]; other site
351627007419	Predicted transcriptional regulators [Transcription]; Region: COG1725
351627007420	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
351627007421	DNA-binding site [nucleotide binding]; DNA binding site
351627007422	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
351627007423	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
351627007424	Walker A/P-loop; other site
351627007425	ATP binding site [chemical binding]; other site
351627007426	Q-loop/lid; other site
351627007427	ABC transporter signature motif; other site
351627007428	Walker B; other site
351627007429	D-loop; other site
351627007430	H-loop/switch region; other site
351627007431	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
351627007432	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627007433	Walker A/P-loop; other site
351627007434	ATP binding site [chemical binding]; other site
351627007435	Q-loop/lid; other site
351627007436	ABC transporter signature motif; other site
351627007437	Walker B; other site
351627007438	D-loop; other site
351627007439	H-loop/switch region; other site
351627007440	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
351627007441	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
351627007442	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
351627007443	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351627007444	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
351627007445	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
351627007446	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
351627007447	TM-ABC transporter signature motif; other site
351627007448	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
351627007449	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
351627007450	Walker A/P-loop; other site
351627007451	ATP binding site [chemical binding]; other site
351627007452	Q-loop/lid; other site
351627007453	ABC transporter signature motif; other site
351627007454	Walker B; other site
351627007455	D-loop; other site
351627007456	H-loop/switch region; other site
351627007457	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
351627007458	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
351627007459	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
351627007460	putative ligand binding site [chemical binding]; other site
351627007461	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
351627007462	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
351627007463	ligand binding site [chemical binding]; other site
351627007464	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627007465	dimerization interface [polypeptide binding]; other site
351627007466	Histidine kinase; Region: His_kinase; pfam06580
351627007467	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627007468	ATP binding site [chemical binding]; other site
351627007469	Mg2+ binding site [ion binding]; other site
351627007470	G-X-G motif; other site
351627007471	Response regulator receiver domain; Region: Response_reg; pfam00072
351627007472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627007473	active site
351627007474	phosphorylation site [posttranslational modification]
351627007475	intermolecular recognition site; other site
351627007476	dimerization interface [polypeptide binding]; other site
351627007477	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627007478	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627007479	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627007480	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
351627007481	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
351627007482	putative ligand binding site [chemical binding]; other site
351627007483	Transposase [DNA replication, recombination, and repair]; Region: COG5421
351627007484	Protein of unknown function DUF72; Region: DUF72; pfam01904
351627007485	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
351627007486	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
351627007487	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627007488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007489	dimer interface [polypeptide binding]; other site
351627007490	conserved gate region; other site
351627007491	putative PBP binding loops; other site
351627007492	ABC-ATPase subunit interface; other site
351627007493	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
351627007494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007495	dimer interface [polypeptide binding]; other site
351627007496	conserved gate region; other site
351627007497	putative PBP binding loops; other site
351627007498	ABC-ATPase subunit interface; other site
351627007499	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627007500	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627007501	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
351627007502	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627007503	dimerization interface [polypeptide binding]; other site
351627007504	Histidine kinase; Region: His_kinase; pfam06580
351627007505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627007506	ATP binding site [chemical binding]; other site
351627007507	Mg2+ binding site [ion binding]; other site
351627007508	G-X-G motif; other site
351627007509	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
351627007510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627007511	active site
351627007512	phosphorylation site [posttranslational modification]
351627007513	intermolecular recognition site; other site
351627007514	dimerization interface [polypeptide binding]; other site
351627007515	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627007516	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
351627007517	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
351627007518	sugar binding site [chemical binding]; other site
351627007519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627007520	MULE transposase domain; Region: MULE; pfam10551
351627007521	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351627007522	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627007523	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627007524	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627007525	dimer interface [polypeptide binding]; other site
351627007526	putative CheW interface [polypeptide binding]; other site
351627007527	Domain of unknown function (DUF377); Region: DUF377; pfam04041
351627007528	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
351627007529	active site
351627007530	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
351627007531	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627007532	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627007533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007534	dimer interface [polypeptide binding]; other site
351627007535	ABC-ATPase subunit interface; other site
351627007536	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627007537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007538	dimer interface [polypeptide binding]; other site
351627007539	conserved gate region; other site
351627007540	putative PBP binding loops; other site
351627007541	ABC-ATPase subunit interface; other site
351627007542	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
351627007543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627007544	active site
351627007545	phosphorylation site [posttranslational modification]
351627007546	intermolecular recognition site; other site
351627007547	dimerization interface [polypeptide binding]; other site
351627007548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627007549	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351627007550	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627007551	dimerization interface [polypeptide binding]; other site
351627007552	Histidine kinase; Region: His_kinase; pfam06580
351627007553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627007554	ATP binding site [chemical binding]; other site
351627007555	Mg2+ binding site [ion binding]; other site
351627007556	G-X-G motif; other site
351627007557	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
351627007558	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
351627007559	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351627007560	non-specific DNA binding site [nucleotide binding]; other site
351627007561	salt bridge; other site
351627007562	sequence-specific DNA binding site [nucleotide binding]; other site
351627007563	Domain of unknown function (DUF955); Region: DUF955; cl01076
351627007564	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
351627007565	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
351627007566	active site
351627007567	dimer interface [polypeptide binding]; other site
351627007568	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
351627007569	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
351627007570	putative active site [active]
351627007571	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
351627007572	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351627007573	Coenzyme A binding pocket [chemical binding]; other site
351627007574	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627007575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007576	dimer interface [polypeptide binding]; other site
351627007577	conserved gate region; other site
351627007578	putative PBP binding loops; other site
351627007579	ABC-ATPase subunit interface; other site
351627007580	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627007581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007582	dimer interface [polypeptide binding]; other site
351627007583	ABC-ATPase subunit interface; other site
351627007584	putative PBP binding loops; other site
351627007585	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627007586	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627007587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627007588	Response regulator receiver domain; Region: Response_reg; pfam00072
351627007589	active site
351627007590	phosphorylation site [posttranslational modification]
351627007591	intermolecular recognition site; other site
351627007592	dimerization interface [polypeptide binding]; other site
351627007593	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627007594	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627007595	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627007596	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
351627007597	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627007598	dimerization interface [polypeptide binding]; other site
351627007599	Histidine kinase; Region: His_kinase; pfam06580
351627007600	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
351627007601	ATP binding site [chemical binding]; other site
351627007602	Mg2+ binding site [ion binding]; other site
351627007603	G-X-G motif; other site
351627007604	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
351627007605	active site
351627007606	catalytic residues [active]
351627007607	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627007608	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627007609	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
351627007610	metal binding site [ion binding]; metal-binding site
351627007611	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627007612	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627007613	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627007614	S-layer homology domain; Region: SLH; pfam00395
351627007615	S-layer homology domain; Region: SLH; pfam00395
351627007616	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
351627007617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627007618	active site
351627007619	phosphorylation site [posttranslational modification]
351627007620	intermolecular recognition site; other site
351627007621	dimerization interface [polypeptide binding]; other site
351627007622	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627007623	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351627007624	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627007625	dimerization interface [polypeptide binding]; other site
351627007626	Histidine kinase; Region: His_kinase; pfam06580
351627007627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627007628	ATP binding site [chemical binding]; other site
351627007629	Mg2+ binding site [ion binding]; other site
351627007630	G-X-G motif; other site
351627007631	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
351627007632	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627007633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007634	dimer interface [polypeptide binding]; other site
351627007635	conserved gate region; other site
351627007636	putative PBP binding loops; other site
351627007637	ABC-ATPase subunit interface; other site
351627007638	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627007639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007640	dimer interface [polypeptide binding]; other site
351627007641	conserved gate region; other site
351627007642	ABC-ATPase subunit interface; other site
351627007643	YycH protein; Region: YycI; pfam09648
351627007644	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
351627007645	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627007646	dimerization interface [polypeptide binding]; other site
351627007647	PAS domain; Region: PAS; smart00091
351627007648	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
351627007649	dimer interface [polypeptide binding]; other site
351627007650	phosphorylation site [posttranslational modification]
351627007651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627007652	ATP binding site [chemical binding]; other site
351627007653	Mg2+ binding site [ion binding]; other site
351627007654	G-X-G motif; other site
351627007655	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
351627007656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627007657	active site
351627007658	phosphorylation site [posttranslational modification]
351627007659	intermolecular recognition site; other site
351627007660	dimerization interface [polypeptide binding]; other site
351627007661	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
351627007662	DNA binding site [nucleotide binding]
351627007663	CTP synthetase; Validated; Region: pyrG; PRK05380
351627007664	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
351627007665	Catalytic site [active]
351627007666	active site
351627007667	UTP binding site [chemical binding]; other site
351627007668	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
351627007669	active site
351627007670	putative oxyanion hole; other site
351627007671	catalytic triad [active]
351627007672	Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907
351627007673	ADP-ribose binding site [chemical binding]; other site
351627007674	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
351627007675	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
351627007676	ADP-ribose binding site [chemical binding]; other site
351627007677	dimer interface [polypeptide binding]; other site
351627007678	active site
351627007679	nudix motif; other site
351627007680	metal binding site [ion binding]; metal-binding site
351627007681	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
351627007682	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
351627007683	active site
351627007684	metal binding site [ion binding]; metal-binding site
351627007685	Bacterial sugar transferase; Region: Bac_transf; pfam02397
351627007686	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
351627007687	putative metal binding site; other site
351627007688	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627007689	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
351627007690	putative ADP-binding pocket [chemical binding]; other site
351627007691	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
351627007692	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627007693	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627007694	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
351627007695	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
351627007696	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
351627007697	O-Antigen ligase; Region: Wzy_C; pfam04932
351627007698	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
351627007699	TPR repeat; Region: TPR_11; pfam13414
351627007700	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
351627007701	binding surface
351627007702	TPR motif; other site
351627007703	Tetratricopeptide repeat; Region: TPR_12; pfam13424
351627007704	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
351627007705	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
351627007706	Integral membrane protein DUF95; Region: DUF95; pfam01944
351627007707	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627007708	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627007709	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
351627007710	Walker A/P-loop; other site
351627007711	ATP binding site [chemical binding]; other site
351627007712	Q-loop/lid; other site
351627007713	ABC transporter signature motif; other site
351627007714	Walker B; other site
351627007715	D-loop; other site
351627007716	H-loop/switch region; other site
351627007717	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
351627007718	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
351627007719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
351627007720	Walker A/P-loop; other site
351627007721	ATP binding site [chemical binding]; other site
351627007722	Q-loop/lid; other site
351627007723	ABC transporter signature motif; other site
351627007724	Walker B; other site
351627007725	D-loop; other site
351627007726	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
351627007727	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
351627007728	GDP-binding site [chemical binding]; other site
351627007729	ACT binding site; other site
351627007730	IMP binding site; other site
351627007731	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
351627007732	Putative amidase domain; Region: Amidase_6; pfam12671
351627007733	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
351627007734	putative active site [active]
351627007735	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
351627007736	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
351627007737	nucleotide binding region [chemical binding]; other site
351627007738	ATP-binding site [chemical binding]; other site
351627007739	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
351627007740	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
351627007741	DNA binding residues [nucleotide binding]
351627007742	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
351627007743	catalytic residues [active]
351627007744	catalytic nucleophile [active]
351627007745	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
351627007746	DEAD-like helicases superfamily; Region: DEXDc; smart00487
351627007747	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351627007748	ATP binding site [chemical binding]; other site
351627007749	putative Mg++ binding site [ion binding]; other site
351627007750	Repair protein; Region: Repair_PSII; pfam04536
351627007751	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
351627007752	putative active site [active]
351627007753	Repair protein; Region: Repair_PSII; pfam04536
351627007754	LemA family; Region: LemA; pfam04011
351627007755	potential frameshift: common BLAST hit: gi|302870749|ref|YP_003839385.1| KWG Leptospira repeat protein
351627007756	KWG Leptospira; Region: KWG; pfam07656
351627007757	Domain of unknown function DUF87; Region: DUF87; pfam01935
351627007758	AAA-like domain; Region: AAA_10; pfam12846
351627007759	NurA domain; Region: NurA; pfam09376
351627007760	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
351627007761	CHC2 zinc finger; Region: zf-CHC2; cl17510
351627007762	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
351627007763	MPN+ (JAMM) motif; other site
351627007764	Zinc-binding site [ion binding]; other site
351627007765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627007766	MULE transposase domain; Region: MULE; pfam10551
351627007767	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
351627007768	RecT family; Region: RecT; pfam03837
351627007769	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
351627007770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
351627007771	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
351627007772	Walker A motif; other site
351627007773	ATP binding site [chemical binding]; other site
351627007774	Walker B motif; other site
351627007775	arginine finger; other site
351627007776	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627007777	MULE transposase domain; Region: MULE; pfam10551
351627007778	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627007779	Integrase core domain; Region: rve; pfam00665
351627007780	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627007781	MULE transposase domain; Region: MULE; pfam10551
351627007782	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
351627007783	Radical SAM superfamily; Region: Radical_SAM; pfam04055
351627007784	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351627007785	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
351627007786	active site
351627007787	DNA binding site [nucleotide binding]
351627007788	Int/Topo IB signature motif; other site
351627007789	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
351627007790	PemK-like protein; Region: PemK; pfam02452
351627007791	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
351627007792	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
351627007793	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
351627007794	N-acetyl-D-glucosamine binding site [chemical binding]; other site
351627007795	catalytic residue [active]
351627007796	Peptidase family M23; Region: Peptidase_M23; pfam01551
351627007797	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
351627007798	Zn2+ binding site [ion binding]; other site
351627007799	Mg2+ binding site [ion binding]; other site
351627007800	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442
351627007801	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
351627007802	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
351627007803	dimer interface [polypeptide binding]; other site
351627007804	ssDNA binding site [nucleotide binding]; other site
351627007805	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
351627007806	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
351627007807	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
351627007808	Ligand binding site; other site
351627007809	Ligand binding site; other site
351627007810	Ligand binding site; other site
351627007811	Putative Catalytic site; other site
351627007812	DXD motif; other site
351627007813	Methyltransferase domain; Region: Methyltransf_23; pfam13489
351627007814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627007815	S-adenosylmethionine binding site [chemical binding]; other site
351627007816	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
351627007817	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627007818	Walker A motif; other site
351627007819	ATP binding site [chemical binding]; other site
351627007820	Walker B motif; other site
351627007821	AAA domain; Region: AAA_31; pfam13614
351627007822	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
351627007823	Domain of unknown function (DUF955); Region: DUF955; cl01076
351627007824	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351627007825	non-specific DNA binding site [nucleotide binding]; other site
351627007826	salt bridge; other site
351627007827	sequence-specific DNA binding site [nucleotide binding]; other site
351627007828	PIN domain; Region: PIN; pfam01850
351627007829	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
351627007830	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
351627007831	Flagellin N-methylase; Region: FliB; pfam03692
351627007832	Probable transposase; Region: OrfB_IS605; pfam01385
351627007833	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
351627007834	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
351627007835	Transposase IS200 like; Region: Y1_Tnp; pfam01797
351627007836	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
351627007837	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
351627007838	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
351627007839	active site
351627007840	RNA/DNA hybrid binding site [nucleotide binding]; other site
351627007841	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
351627007842	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
351627007843	RNA binding site [nucleotide binding]; other site
351627007844	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
351627007845	RNA binding site [nucleotide binding]; other site
351627007846	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
351627007847	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
351627007848	Walker A motif; other site
351627007849	ATP binding site [chemical binding]; other site
351627007850	Walker B motif; other site
351627007851	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
351627007852	nucleotide binding site [chemical binding]; other site
351627007853	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
351627007854	AAA-like domain; Region: AAA_10; pfam12846
351627007855	Domain of unknown function DUF87; Region: DUF87; pfam01935
351627007856	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
351627007857	PrgI family protein; Region: PrgI; pfam12666
351627007858	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
351627007859	DNA-binding interface [nucleotide binding]; DNA binding site
351627007860	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
351627007861	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
351627007862	Int/Topo IB signature motif; other site
351627007863	Protein of unknown function DUF45; Region: DUF45; pfam01863
351627007864	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
351627007865	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
351627007866	ATP binding site [chemical binding]; other site
351627007867	putative Mg++ binding site [ion binding]; other site
351627007868	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
351627007869	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
351627007870	Protein of unknown function DUF86; Region: DUF86; cl01031
351627007871	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
351627007872	active site
351627007873	NTP binding site [chemical binding]; other site
351627007874	metal binding triad [ion binding]; metal-binding site
351627007875	antibiotic binding site [chemical binding]; other site
351627007876	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
351627007877	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
351627007878	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
351627007879	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
351627007880	Divergent AAA domain; Region: AAA_4; pfam04326
351627007881	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
351627007882	HsdM N-terminal domain; Region: HsdM_N; pfam12161
351627007883	Methyltransferase domain; Region: Methyltransf_26; pfam13659
351627007884	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
351627007885	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
351627007886	active site
351627007887	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
351627007888	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
351627007889	Walker A/P-loop; other site
351627007890	ATP binding site [chemical binding]; other site
351627007891	Q-loop/lid; other site
351627007892	ABC transporter signature motif; other site
351627007893	Walker B; other site
351627007894	D-loop; other site
351627007895	H-loop/switch region; other site
351627007896	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
351627007897	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
351627007898	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
351627007899	mannonate dehydratase; Provisional; Region: PRK03906
351627007900	mannonate dehydratase; Region: uxuA; TIGR00695
351627007901	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
351627007902	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
351627007903	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
351627007904	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
351627007905	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
351627007906	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
351627007907	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
351627007908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
351627007909	active site
351627007910	phosphorylation site [posttranslational modification]
351627007911	intermolecular recognition site; other site
351627007912	dimerization interface [polypeptide binding]; other site
351627007913	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627007914	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
351627007915	HAMP domain; Region: HAMP; pfam00672
351627007916	Histidine kinase; Region: His_kinase; pfam06580
351627007917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
351627007918	ATP binding site [chemical binding]; other site
351627007919	Mg2+ binding site [ion binding]; other site
351627007920	G-X-G motif; other site
351627007921	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627007922	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007923	dimer interface [polypeptide binding]; other site
351627007924	ABC-ATPase subunit interface; other site
351627007925	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627007926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627007927	dimer interface [polypeptide binding]; other site
351627007928	conserved gate region; other site
351627007929	ABC-ATPase subunit interface; other site
351627007930	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
351627007931	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627007932	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
351627007933	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627007934	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627007935	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
351627007936	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
351627007937	pyridoxal 5'-phosphate binding site [chemical binding]; other site
351627007938	homodimer interface [polypeptide binding]; other site
351627007939	catalytic residue [active]
351627007940	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
351627007941	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
351627007942	Uncharacterized protein family (UPF0146); Region: UPF0146; cl00552
351627007943	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
351627007944	prephenate dehydrogenase; Validated; Region: PRK08507
351627007945	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
351627007946	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
351627007947	hinge; other site
351627007948	active site
351627007949	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
351627007950	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
351627007951	DNA interaction; other site
351627007952	Metal-binding active site; metal-binding site
351627007953	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
351627007954	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
351627007955	Integrase core domain; Region: rve; pfam00665
351627007956	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
351627007957	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
351627007958	Coenzyme A binding pocket [chemical binding]; other site
351627007959	Coat F domain; Region: Coat_F; pfam07875
351627007960	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
351627007961	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
351627007962	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
351627007963	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
351627007964	tetramerization interface [polypeptide binding]; other site
351627007965	active site
351627007966	pantoate--beta-alanine ligase; Region: panC; TIGR00018
351627007967	Pantoate-beta-alanine ligase; Region: PanC; cd00560
351627007968	active site
351627007969	ATP-binding site [chemical binding]; other site
351627007970	pantoate-binding site; other site
351627007971	HXXH motif; other site
351627007972	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
351627007973	oligomerization interface [polypeptide binding]; other site
351627007974	active site
351627007975	metal binding site [ion binding]; metal-binding site
351627007976	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
351627007977	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
351627007978	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
351627007979	Ferritin-like domain; Region: Ferritin; pfam00210
351627007980	ferroxidase diiron center [ion binding]; other site
351627007981	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
351627007982	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
351627007983	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
351627007984	Int/Topo IB signature motif; other site
351627007985	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
351627007986	Transposase; Region: DDE_Tnp_ISL3; pfam01610
351627007987	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
351627007988	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
351627007989	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
351627007990	Transposase; Region: DDE_Tnp_ISL3; pfam01610
351627007991	Transposase; Region: DEDD_Tnp_IS110; pfam01548
351627007992	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
351627007993	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
351627007994	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
351627007995	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
351627007996	NADP binding site [chemical binding]; other site
351627007997	homodimer interface [polypeptide binding]; other site
351627007998	active site
351627007999	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
351627008000	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
351627008001	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
351627008002	substrate binding site [chemical binding]; other site
351627008003	ATP binding site [chemical binding]; other site
351627008004	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
351627008005	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627008006	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
351627008007	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
351627008008	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
351627008009	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
351627008010	S-layer homology domain; Region: SLH; pfam00395
351627008011	S-layer homology domain; Region: SLH; pfam00395
351627008012	S-layer homology domain; Region: SLH; pfam00395
351627008013	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
351627008014	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
351627008015	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627008016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627008017	dimer interface [polypeptide binding]; other site
351627008018	ABC-ATPase subunit interface; other site
351627008019	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
351627008020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627008021	dimer interface [polypeptide binding]; other site
351627008022	conserved gate region; other site
351627008023	putative PBP binding loops; other site
351627008024	ABC-ATPase subunit interface; other site
351627008025	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627008026	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
351627008027	Cache domain; Region: Cache_1; pfam02743
351627008028	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
351627008029	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
351627008030	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
351627008031	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
351627008032	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
351627008033	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
351627008034	active site
351627008035	catalytic triad [active]
351627008036	dimer interface [polypeptide binding]; other site
351627008037	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
351627008038	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
351627008039	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
351627008040	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
351627008041	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
351627008042	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
351627008043	Transcriptional regulator [Transcription]; Region: IclR; COG1414
351627008044	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
351627008045	Bacterial transcriptional regulator; Region: IclR; pfam01614
351627008046	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
351627008047	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
351627008048	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
351627008049	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
351627008050	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
351627008051	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
351627008052	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
351627008053	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
351627008054	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
351627008055	active site pocket [active]
351627008056	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
351627008057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627008058	dimer interface [polypeptide binding]; other site
351627008059	conserved gate region; other site
351627008060	putative PBP binding loops; other site
351627008061	ABC-ATPase subunit interface; other site
351627008062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
351627008063	dimer interface [polypeptide binding]; other site
351627008064	conserved gate region; other site
351627008065	putative PBP binding loops; other site
351627008066	ABC-ATPase subunit interface; other site
351627008067	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
351627008068	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
351627008069	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
351627008070	dihydrodipicolinate synthase; Region: dapA; TIGR00674
351627008071	active site
351627008072	inhibitor site; inhibition site
351627008073	dimer interface [polypeptide binding]; other site
351627008074	catalytic residue [active]
351627008075	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
351627008076	MULE transposase domain; Region: MULE; pfam10551
351627008077	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351627008078	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
351627008079	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
351627008080	putative active site [active]
351627008081	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
351627008082	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
351627008083	NAD binding site [chemical binding]; other site
351627008084	sugar binding site [chemical binding]; other site
351627008085	divalent metal binding site [ion binding]; other site
351627008086	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
351627008087	dimer interface [polypeptide binding]; other site
351627008088	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
351627008089	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
351627008090	AlwI restriction endonuclease; Region: RE_AlwI; pfam09491
351627008091	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
351627008092	DNA methylase; Region: N6_N4_Mtase; pfam01555
351627008093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627008094	S-adenosylmethionine binding site [chemical binding]; other site
351627008095	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
351627008096	DNA methylase; Region: N6_N4_Mtase; pfam01555
351627008097	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627008098	S-adenosylmethionine binding site [chemical binding]; other site
351627008099	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
351627008100	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
351627008101	dimerization interface [polypeptide binding]; other site
351627008102	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
351627008103	dimer interface [polypeptide binding]; other site
351627008104	putative CheW interface [polypeptide binding]; other site
351627008105	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
351627008106	fumarate hydratase; Provisional; Region: PRK06246
351627008107	PAS domain; Region: PAS_9; pfam13426
351627008108	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
351627008109	ParB-like nuclease domain; Region: ParB; smart00470
351627008110	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
351627008111	non-specific DNA binding site [nucleotide binding]; other site
351627008112	salt bridge; other site
351627008113	sequence-specific DNA binding site [nucleotide binding]; other site
351627008114	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
351627008115	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351627008116	P-loop; other site
351627008117	Magnesium ion binding site [ion binding]; other site
351627008118	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
351627008119	Magnesium ion binding site [ion binding]; other site
351627008120	Bacterial Ig-like domain; Region: Big_5; pfam13205
351627008121	PBP superfamily domain; Region: PBP_like_2; cl17296
351627008122	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
351627008123	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
351627008124	dimer interface [polypeptide binding]; other site
351627008125	Alkaline phosphatase homologues; Region: alkPPc; smart00098
351627008126	active site
351627008127	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
351627008128	ParB-like nuclease domain; Region: ParB; smart00470
351627008129	KorB domain; Region: KorB; pfam08535
351627008130	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
351627008131	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
351627008132	S-adenosylmethionine binding site [chemical binding]; other site
351627008133	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
351627008134	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
351627008135	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
351627008136	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
351627008137	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
351627008138	trmE is a tRNA modification GTPase; Region: trmE; cd04164
351627008139	G1 box; other site
351627008140	GTP/Mg2+ binding site [chemical binding]; other site
351627008141	Switch I region; other site
351627008142	G2 box; other site
351627008143	Switch II region; other site
351627008144	G3 box; other site
351627008145	G4 box; other site
351627008146	G5 box; other site
351627008147	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
351627008148	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
351627008149	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
351627008150	G-X-X-G motif; other site
351627008151	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
351627008152	RxxxH motif; other site
351627008153	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
351627008154	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
351627008155	Haemolytic domain; Region: Haemolytic; pfam01809
351627008156	Ribonuclease P; Region: Ribonuclease_P; pfam00825
351627008157	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
351627008158	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
351627008159	Spore germination protein; Region: Spore_permease; cl17796
351627008160	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
351627008161	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504