-- dump date 20140619_020728 -- class Genbank::misc_feature -- table misc_feature_note -- id note 511051000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 511051000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 511051000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051000004 Walker A motif; other site 511051000005 ATP binding site [chemical binding]; other site 511051000006 Walker B motif; other site 511051000007 arginine finger; other site 511051000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 511051000009 DnaA box-binding interface [nucleotide binding]; other site 511051000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 511051000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 511051000012 putative DNA binding surface [nucleotide binding]; other site 511051000013 dimer interface [polypeptide binding]; other site 511051000014 beta-clamp/clamp loader binding surface; other site 511051000015 beta-clamp/translesion DNA polymerase binding surface; other site 511051000016 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 511051000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051000018 Walker A/P-loop; other site 511051000019 ATP binding site [chemical binding]; other site 511051000020 Q-loop/lid; other site 511051000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051000022 ABC transporter signature motif; other site 511051000023 Walker B; other site 511051000024 D-loop; other site 511051000025 H-loop/switch region; other site 511051000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 511051000027 BioY family; Region: BioY; pfam02632 511051000028 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 511051000029 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 511051000030 homodimer interface [polypeptide binding]; other site 511051000031 substrate-cofactor binding pocket; other site 511051000032 catalytic residue [active] 511051000033 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 511051000034 PAS domain S-box; Region: sensory_box; TIGR00229 511051000035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511051000036 putative active site [active] 511051000037 heme pocket [chemical binding]; other site 511051000038 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 511051000039 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000040 metal binding site [ion binding]; metal-binding site 511051000041 active site 511051000042 I-site; other site 511051000043 PAS domain; Region: PAS; smart00091 511051000044 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 511051000045 Clp amino terminal domain; Region: Clp_N; pfam02861 511051000046 Clp amino terminal domain; Region: Clp_N; pfam02861 511051000047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051000048 Walker A motif; other site 511051000049 ATP binding site [chemical binding]; other site 511051000050 Walker B motif; other site 511051000051 arginine finger; other site 511051000052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051000053 Walker A motif; other site 511051000054 ATP binding site [chemical binding]; other site 511051000055 Walker B motif; other site 511051000056 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511051000057 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 511051000058 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 511051000059 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 511051000060 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 511051000061 metal binding triad [ion binding]; metal-binding site 511051000062 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN [Function unknown]; Region: COG2250 511051000063 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 511051000064 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051000065 dimer interface [polypeptide binding]; other site 511051000066 PYR/PP interface [polypeptide binding]; other site 511051000067 TPP binding site [chemical binding]; other site 511051000068 substrate binding site [chemical binding]; other site 511051000069 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511051000070 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 511051000071 TPP-binding site; other site 511051000072 4Fe-4S binding domain; Region: Fer4_6; pfam12837 511051000073 Cation efflux family; Region: Cation_efflux; cl00316 511051000074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511051000075 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511051000076 Coenzyme A binding pocket [chemical binding]; other site 511051000077 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 511051000078 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000079 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 511051000080 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511051000081 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 511051000082 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 511051000083 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 511051000084 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 511051000085 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 511051000086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000087 FeS/SAM binding site; other site 511051000088 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 511051000089 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 511051000090 NAD synthetase; Provisional; Region: PRK13980 511051000091 homodimer interface [polypeptide binding]; other site 511051000092 NAD binding pocket [chemical binding]; other site 511051000093 ATP binding pocket [chemical binding]; other site 511051000094 Mg binding site [ion binding]; other site 511051000095 active-site loop [active] 511051000096 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 511051000097 AAA domain; Region: AAA_14; pfam13173 511051000098 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511051000099 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 511051000100 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511051000101 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 511051000102 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511051000103 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511051000104 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 511051000105 HTH domain; Region: HTH_11; pfam08279 511051000106 3H domain; Region: 3H; pfam02829 511051000107 benzoate transport; Region: 2A0115; TIGR00895 511051000108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000110 NTPase; Region: NTPase_1; cl17478 511051000111 Uncharacterized conserved protein [Function unknown]; Region: COG2014 511051000112 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 511051000113 Domain of unknown function (DUF364); Region: DUF364; pfam04016 511051000114 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000115 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 511051000116 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 511051000117 intersubunit interface [polypeptide binding]; other site 511051000118 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 511051000119 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511051000120 Walker A/P-loop; other site 511051000121 ATP binding site [chemical binding]; other site 511051000122 Q-loop/lid; other site 511051000123 ABC transporter signature motif; other site 511051000124 Walker B; other site 511051000125 D-loop; other site 511051000126 H-loop/switch region; other site 511051000127 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 511051000128 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511051000129 ABC-ATPase subunit interface; other site 511051000130 dimer interface [polypeptide binding]; other site 511051000131 putative PBP binding regions; other site 511051000132 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 511051000133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051000135 putative substrate translocation pore; other site 511051000136 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051000137 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051000138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 511051000139 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 511051000140 Putative amidase domain; Region: Amidase_6; pfam12671 511051000141 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051000142 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051000143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 511051000144 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 511051000145 BNR repeat-like domain; Region: BNR_2; pfam13088 511051000146 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 511051000147 Asp-box motif; other site 511051000148 Putative amidase domain; Region: Amidase_6; pfam12671 511051000149 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511051000150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051000151 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051000152 DNA binding residues [nucleotide binding] 511051000153 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511051000154 IHF dimer interface [polypeptide binding]; other site 511051000155 IHF - DNA interface [nucleotide binding]; other site 511051000156 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511051000157 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511051000158 P-loop; other site 511051000159 Magnesium ion binding site [ion binding]; other site 511051000160 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511051000161 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511051000162 Magnesium ion binding site [ion binding]; other site 511051000163 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511051000164 IHF dimer interface [polypeptide binding]; other site 511051000165 IHF - DNA interface [nucleotide binding]; other site 511051000166 Initiator Replication protein; Region: Rep_3; pfam01051 511051000167 Domain of unknown function (DUF239); Region: DUF239; pfam03080 511051000168 beta-galactosidase; Provisional; Region: PLN03059 511051000169 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511051000170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051000171 Walker A/P-loop; other site 511051000172 ATP binding site [chemical binding]; other site 511051000173 Q-loop/lid; other site 511051000174 ABC transporter signature motif; other site 511051000175 Walker B; other site 511051000176 D-loop; other site 511051000177 H-loop/switch region; other site 511051000178 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 511051000179 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 511051000180 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 511051000181 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 511051000182 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 511051000183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511051000184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511051000185 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 511051000186 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 511051000187 putative NADP binding site [chemical binding]; other site 511051000188 putative substrate binding site [chemical binding]; other site 511051000189 active site 511051000190 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 511051000191 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511051000192 Walker A/P-loop; other site 511051000193 ATP binding site [chemical binding]; other site 511051000194 Q-loop/lid; other site 511051000195 ABC transporter signature motif; other site 511051000196 Walker B; other site 511051000197 D-loop; other site 511051000198 H-loop/switch region; other site 511051000199 TOBE domain; Region: TOBE; cl01440 511051000200 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 511051000201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000202 dimer interface [polypeptide binding]; other site 511051000203 conserved gate region; other site 511051000204 putative PBP binding loops; other site 511051000205 ABC-ATPase subunit interface; other site 511051000206 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 511051000207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000208 FeS/SAM binding site; other site 511051000209 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 511051000210 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511051000211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051000212 Walker A/P-loop; other site 511051000213 ATP binding site [chemical binding]; other site 511051000214 Q-loop/lid; other site 511051000215 ABC transporter signature motif; other site 511051000216 Walker B; other site 511051000217 D-loop; other site 511051000218 H-loop/switch region; other site 511051000219 potential frameshift: common BLAST hit: gi|20807599|ref|NP_622770.1| ABC-type multidrug transport system, permease component 511051000220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000221 Radical SAM superfamily; Region: Radical_SAM; pfam04055 511051000222 FeS/SAM binding site; other site 511051000223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000224 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051000225 putative substrate translocation pore; other site 511051000226 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000227 FeS/SAM binding site; other site 511051000228 HTH-like domain; Region: HTH_21; pfam13276 511051000229 Integrase core domain; Region: rve; pfam00665 511051000230 Integrase core domain; Region: rve_3; pfam13683 511051000231 YcaO-like family; Region: YcaO; pfam02624 511051000232 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 511051000233 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 511051000234 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 511051000235 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 511051000236 putative FMN binding site [chemical binding]; other site 511051000237 NADPH bind site [chemical binding]; other site 511051000238 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511051000239 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511051000240 Walker A/P-loop; other site 511051000241 ATP binding site [chemical binding]; other site 511051000242 Q-loop/lid; other site 511051000243 ABC transporter signature motif; other site 511051000244 Walker B; other site 511051000245 D-loop; other site 511051000246 H-loop/switch region; other site 511051000247 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 511051000248 Peptidase family M50; Region: Peptidase_M50; pfam02163 511051000249 active site 511051000250 CAAX protease self-immunity; Region: Abi; pfam02517 511051000251 Integrase core domain; Region: rve_3; pfam13683 511051000252 Transposase domain (DUF772); Region: DUF772; pfam05598 511051000253 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511051000254 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 511051000255 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051000256 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511051000257 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 511051000258 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000259 FeS/SAM binding site; other site 511051000260 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051000261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000262 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511051000263 dimerization interface [polypeptide binding]; other site 511051000264 putative DNA binding site [nucleotide binding]; other site 511051000265 putative Zn2+ binding site [ion binding]; other site 511051000266 Predicted integral membrane protein [Function unknown]; Region: COG5658 511051000267 SdpI/YhfL protein family; Region: SdpI; pfam13630 511051000268 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 511051000269 SdpI/YhfL protein family; Region: SdpI; pfam13630 511051000270 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511051000271 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511051000272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051000273 Walker A/P-loop; other site 511051000274 ATP binding site [chemical binding]; other site 511051000275 Q-loop/lid; other site 511051000276 ABC transporter signature motif; other site 511051000277 Walker B; other site 511051000278 D-loop; other site 511051000279 H-loop/switch region; other site 511051000280 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 511051000281 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000282 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000283 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 511051000284 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 511051000285 PAS domain; Region: PAS_10; pfam13596 511051000286 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511051000287 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 511051000288 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511051000289 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 511051000290 putative active site [active] 511051000291 putative metal binding site [ion binding]; other site 511051000292 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 511051000293 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 511051000294 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511051000295 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511051000296 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511051000297 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511051000298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511051000299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051000300 dimer interface [polypeptide binding]; other site 511051000301 phosphorylation site [posttranslational modification] 511051000302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051000303 ATP binding site [chemical binding]; other site 511051000304 Mg2+ binding site [ion binding]; other site 511051000305 G-X-G motif; other site 511051000306 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511051000307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051000308 active site 511051000309 phosphorylation site [posttranslational modification] 511051000310 intermolecular recognition site; other site 511051000311 dimerization interface [polypeptide binding]; other site 511051000312 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511051000313 DNA binding site [nucleotide binding] 511051000314 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 511051000315 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 511051000316 active site 511051000317 Predicted membrane protein [Function unknown]; Region: COG3212 511051000318 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 511051000319 Putative amidase domain; Region: Amidase_6; pfam12671 511051000320 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511051000321 NTPase; Region: NTPase_1; pfam03266 511051000322 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 511051000323 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 511051000324 DXD motif; other site 511051000325 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 511051000326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000327 dimer interface [polypeptide binding]; other site 511051000328 conserved gate region; other site 511051000329 putative PBP binding loops; other site 511051000330 ABC-ATPase subunit interface; other site 511051000331 NMT1/THI5 like; Region: NMT1; pfam09084 511051000332 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 511051000333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051000334 Walker A/P-loop; other site 511051000335 ATP binding site [chemical binding]; other site 511051000336 Q-loop/lid; other site 511051000337 ABC transporter signature motif; other site 511051000338 Walker B; other site 511051000339 D-loop; other site 511051000340 H-loop/switch region; other site 511051000341 FOG: WD40-like repeat [Function unknown]; Region: COG1520 511051000342 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000343 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000344 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 511051000345 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 511051000346 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000347 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 511051000348 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 511051000349 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000350 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000351 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 511051000352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051000353 FeS/SAM binding site; other site 511051000354 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051000355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000356 putative substrate translocation pore; other site 511051000357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051000358 Chromate transporter; Region: Chromate_transp; pfam02417 511051000359 Chromate transporter; Region: Chromate_transp; pfam02417 511051000360 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511051000361 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 511051000362 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 511051000363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511051000364 putative active site [active] 511051000365 heme pocket [chemical binding]; other site 511051000366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051000367 Walker A motif; other site 511051000368 ATP binding site [chemical binding]; other site 511051000369 Walker B motif; other site 511051000370 arginine finger; other site 511051000371 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511051000372 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 511051000373 trimer interface [polypeptide binding]; other site 511051000374 putative Zn binding site [ion binding]; other site 511051000375 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 511051000376 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 511051000377 tetramer interface [polypeptide binding]; other site 511051000378 TPP-binding site [chemical binding]; other site 511051000379 heterodimer interface [polypeptide binding]; other site 511051000380 phosphorylation loop region [posttranslational modification] 511051000381 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 511051000382 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 511051000383 alpha subunit interface [polypeptide binding]; other site 511051000384 TPP binding site [chemical binding]; other site 511051000385 heterodimer interface [polypeptide binding]; other site 511051000386 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511051000387 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 511051000388 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511051000389 E3 interaction surface; other site 511051000390 lipoyl attachment site [posttranslational modification]; other site 511051000391 e3 binding domain; Region: E3_binding; pfam02817 511051000392 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 511051000393 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000394 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000395 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 511051000396 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 511051000397 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 511051000398 DctM-like transporters; Region: DctM; pfam06808 511051000399 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 511051000400 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511051000401 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 511051000402 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 511051000403 dimer interface [polypeptide binding]; other site 511051000404 active site 511051000405 CoA binding pocket [chemical binding]; other site 511051000406 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 511051000407 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 511051000408 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 511051000409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051000410 NAD(P) binding site [chemical binding]; other site 511051000411 active site 511051000412 acyl carrier protein; Provisional; Region: acpP; PRK00982 511051000413 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 511051000414 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 511051000415 dimer interface [polypeptide binding]; other site 511051000416 active site 511051000417 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 511051000418 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 511051000419 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051000420 dimer interface [polypeptide binding]; other site 511051000421 PYR/PP interface [polypeptide binding]; other site 511051000422 TPP binding site [chemical binding]; other site 511051000423 substrate binding site [chemical binding]; other site 511051000424 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11866 511051000425 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 511051000426 TPP-binding site [chemical binding]; other site 511051000427 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 511051000428 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 511051000429 diiron binding motif [ion binding]; other site 511051000430 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 511051000431 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 511051000432 Uncharacterized conserved protein [Function unknown]; Region: COG3350 511051000433 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 511051000434 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 511051000435 metal-binding site [ion binding] 511051000436 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511051000437 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511051000438 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 511051000439 putative homodimer interface [polypeptide binding]; other site 511051000440 putative homotetramer interface [polypeptide binding]; other site 511051000441 putative allosteric switch controlling residues; other site 511051000442 putative metal binding site [ion binding]; other site 511051000443 putative homodimer-homodimer interface [polypeptide binding]; other site 511051000444 Short C-terminal domain; Region: SHOCT; pfam09851 511051000445 potential frameshift: common BLAST hit: gi|320159705|ref|YP_004172929.1| amidohydrolase family protein 511051000446 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051000447 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 511051000448 active site 511051000449 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 511051000450 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051000451 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 511051000452 S-layer homology domain; Region: SLH; pfam00395 511051000453 S-layer homology domain; Region: SLH; pfam00395 511051000454 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 511051000455 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 511051000456 active site 511051000457 metal binding site [ion binding]; metal-binding site 511051000458 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511051000459 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 511051000460 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 511051000461 ATP cone domain; Region: ATP-cone; pfam03477 511051000462 Class III ribonucleotide reductase; Region: RNR_III; cd01675 511051000463 effector binding site; other site 511051000464 active site 511051000465 Zn binding site [ion binding]; other site 511051000466 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511051000467 IHF dimer interface [polypeptide binding]; other site 511051000468 IHF - DNA interface [nucleotide binding]; other site 511051000469 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 511051000470 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 511051000471 putative ligand binding site [chemical binding]; other site 511051000472 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511051000473 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 511051000474 TM-ABC transporter signature motif; other site 511051000475 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 511051000476 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 511051000477 TM-ABC transporter signature motif; other site 511051000478 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 511051000479 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 511051000480 Walker A/P-loop; other site 511051000481 ATP binding site [chemical binding]; other site 511051000482 Q-loop/lid; other site 511051000483 ABC transporter signature motif; other site 511051000484 Walker B; other site 511051000485 D-loop; other site 511051000486 H-loop/switch region; other site 511051000487 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 511051000488 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 511051000489 Walker A/P-loop; other site 511051000490 ATP binding site [chemical binding]; other site 511051000491 Q-loop/lid; other site 511051000492 ABC transporter signature motif; other site 511051000493 Walker B; other site 511051000494 D-loop; other site 511051000495 H-loop/switch region; other site 511051000496 Yqey-like protein; Region: YqeY; cl17540 511051000497 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511051000498 nucleotide binding site [chemical binding]; other site 511051000499 Acetokinase family; Region: Acetate_kinase; cl17229 511051000500 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511051000501 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 511051000502 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511051000503 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 511051000504 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051000505 dimer interface [polypeptide binding]; other site 511051000506 PYR/PP interface [polypeptide binding]; other site 511051000507 TPP binding site [chemical binding]; other site 511051000508 substrate binding site [chemical binding]; other site 511051000509 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 511051000510 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 511051000511 TPP-binding site [chemical binding]; other site 511051000512 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 511051000513 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 511051000514 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 511051000515 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 511051000516 classical (c) SDRs; Region: SDR_c; cd05233 511051000517 NAD(P) binding site [chemical binding]; other site 511051000518 active site 511051000519 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 511051000520 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051000521 active site 511051000522 metal binding site [ion binding]; metal-binding site 511051000523 DNA binding site [nucleotide binding] 511051000524 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 511051000525 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 511051000526 N-acetyl-D-glucosamine binding site [chemical binding]; other site 511051000527 catalytic residue [active] 511051000528 PEGA domain; Region: PEGA; pfam08308 511051000529 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 511051000530 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000531 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 511051000532 MPT binding site; other site 511051000533 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511051000534 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 511051000535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 511051000536 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 511051000537 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 511051000538 phosphate binding site [ion binding]; other site 511051000539 4Fe-4S binding domain; Region: Fer4; pfam00037 511051000540 4Fe-4S binding domain; Region: Fer4; pfam00037 511051000541 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 511051000542 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511051000543 catalytic loop [active] 511051000544 iron binding site [ion binding]; other site 511051000545 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 511051000546 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 511051000547 Ligand binding site; other site 511051000548 metal-binding site 511051000549 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 511051000550 XdhC Rossmann domain; Region: XdhC_C; pfam13478 511051000551 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 511051000552 FAD binding domain; Region: FAD_binding_4; pfam01565 511051000553 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 511051000554 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 511051000555 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 511051000556 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 511051000557 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 511051000558 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 511051000559 active site 511051000560 putative substrate binding pocket [chemical binding]; other site 511051000561 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511051000562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051000563 Walker A/P-loop; other site 511051000564 ATP binding site [chemical binding]; other site 511051000565 Q-loop/lid; other site 511051000566 ABC transporter signature motif; other site 511051000567 Walker B; other site 511051000568 D-loop; other site 511051000569 H-loop/switch region; other site 511051000570 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 511051000571 ABC-2 type transporter; Region: ABC2_membrane; cl17235 511051000572 ABC-2 type transporter; Region: ABC2_membrane; cl17235 511051000573 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 511051000574 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 511051000575 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000576 Interdomain contacts; other site 511051000577 Cytokine receptor motif; other site 511051000578 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000579 Interdomain contacts; other site 511051000580 Cytokine receptor motif; other site 511051000581 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000582 Interdomain contacts; other site 511051000583 Cytokine receptor motif; other site 511051000584 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000585 Interdomain contacts; other site 511051000586 Cytokine receptor motif; other site 511051000587 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000588 Interdomain contacts; other site 511051000589 Cytokine receptor motif; other site 511051000590 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000591 Interdomain contacts; other site 511051000592 Cytokine receptor motif; other site 511051000593 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000594 Interdomain contacts; other site 511051000595 Cytokine receptor motif; other site 511051000596 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000597 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 511051000598 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 511051000599 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000600 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511051000601 nucleotide binding site [chemical binding]; other site 511051000602 Acetokinase family; Region: Acetate_kinase; cl17229 511051000603 Domain of unknown function DUF11; Region: DUF11; pfam01345 511051000604 Domain of unknown function DUF11; Region: DUF11; pfam01345 511051000605 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 511051000606 Domain of unknown function DUF11; Region: DUF11; pfam01345 511051000607 Domain of unknown function DUF11; Region: DUF11; pfam01345 511051000608 Domain of unknown function DUF11; Region: DUF11; pfam01345 511051000609 Domain of unknown function DUF11; Region: DUF11; pfam01345 511051000610 Domain of unknown function DUF11; Region: DUF11; pfam01345 511051000611 Domain of unknown function DUF11; Region: DUF11; pfam01345 511051000612 conserved repeat domain; Region: B_ant_repeat; TIGR01451 511051000613 conserved repeat domain; Region: B_ant_repeat; TIGR01451 511051000614 conserved repeat domain; Region: B_ant_repeat; TIGR01451 511051000615 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 511051000616 S-layer homology domain; Region: SLH; pfam00395 511051000617 S-layer homology domain; Region: SLH; pfam00395 511051000618 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511051000619 dimerization interface [polypeptide binding]; other site 511051000620 putative DNA binding site [nucleotide binding]; other site 511051000621 putative Zn2+ binding site [ion binding]; other site 511051000622 DGC domain; Region: DGC; cl01742 511051000623 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 511051000624 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511051000625 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 511051000626 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 511051000627 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 511051000628 dimer interface [polypeptide binding]; other site 511051000629 catalytic triad [active] 511051000630 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 511051000631 FMN binding site [chemical binding]; other site 511051000632 dimer interface [polypeptide binding]; other site 511051000633 Isochorismatase family; Region: Isochorismatase; pfam00857 511051000634 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511051000635 catalytic triad [active] 511051000636 conserved cis-peptide bond; other site 511051000637 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 511051000638 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 511051000639 Ligand Binding Site [chemical binding]; other site 511051000640 TIGR00269 family protein; Region: TIGR00269 511051000641 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 511051000642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051000643 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 511051000644 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000645 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000646 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000647 Interdomain contacts; other site 511051000648 Cytokine receptor motif; other site 511051000649 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 511051000650 Interdomain contacts; other site 511051000651 Cytokine receptor motif; other site 511051000652 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 511051000653 AAA ATPase domain; Region: AAA_16; pfam13191 511051000654 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 511051000655 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 511051000656 AAA ATPase domain; Region: AAA_16; pfam13191 511051000657 AAA domain; Region: AAA_14; pfam13173 511051000658 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 511051000659 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 511051000660 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 511051000661 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 511051000662 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 511051000663 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 511051000664 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687 511051000665 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 511051000666 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 511051000667 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 511051000668 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 511051000669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 511051000670 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 511051000671 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 511051000672 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 511051000673 Arginine repressor [Transcription]; Region: ArgR; COG1438 511051000674 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511051000675 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511051000676 argininosuccinate synthase; Provisional; Region: PRK13820 511051000677 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 511051000678 ANP binding site [chemical binding]; other site 511051000679 Substrate Binding Site II [chemical binding]; other site 511051000680 Substrate Binding Site I [chemical binding]; other site 511051000681 Lyase; Region: Lyase_1; pfam00206 511051000682 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 511051000683 active sites [active] 511051000684 tetramer interface [polypeptide binding]; other site 511051000685 S-layer homology domain; Region: SLH; pfam00395 511051000686 S-layer homology domain; Region: SLH; pfam00395 511051000687 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511051000688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051000689 DNA binding residues [nucleotide binding] 511051000690 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 511051000691 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 511051000692 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 511051000693 potential frameshift: common BLAST hit: gi|298675969|ref|YP_003727719.1| cobyrinic acid ac-diamide synthase 511051000694 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511051000695 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 511051000696 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 511051000697 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 511051000698 switch II; other site 511051000699 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 511051000700 NlpC/P60 family; Region: NLPC_P60; pfam00877 511051000701 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 511051000702 dimer interface [polypeptide binding]; other site 511051000703 catalytic triad [active] 511051000704 diaminopimelate decarboxylase; Region: lysA; TIGR01048 511051000705 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 511051000706 active site 511051000707 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511051000708 substrate binding site [chemical binding]; other site 511051000709 catalytic residues [active] 511051000710 dimer interface [polypeptide binding]; other site 511051000711 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 511051000712 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 511051000713 active site 511051000714 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511051000715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511051000716 DNA-binding site [nucleotide binding]; DNA binding site 511051000717 UTRA domain; Region: UTRA; pfam07702 511051000718 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511051000719 nucleotide binding site [chemical binding]; other site 511051000720 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 511051000721 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 511051000722 putative active site [active] 511051000723 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 511051000724 S-layer homology domain; Region: SLH; pfam00395 511051000725 S-layer homology domain; Region: SLH; pfam00395 511051000726 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 511051000727 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 511051000728 peptide binding site [polypeptide binding]; other site 511051000729 dimer interface [polypeptide binding]; other site 511051000730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511051000731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000732 dimer interface [polypeptide binding]; other site 511051000733 conserved gate region; other site 511051000734 putative PBP binding loops; other site 511051000735 ABC-ATPase subunit interface; other site 511051000736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 511051000737 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 511051000738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051000739 dimer interface [polypeptide binding]; other site 511051000740 conserved gate region; other site 511051000741 putative PBP binding loops; other site 511051000742 ABC-ATPase subunit interface; other site 511051000743 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 511051000744 AP (apurinic/apyrimidinic) site pocket; other site 511051000745 Metal-binding active site; metal-binding site 511051000746 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 511051000747 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 511051000748 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 511051000749 Beta-lactamase; Region: Beta-lactamase; pfam00144 511051000750 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 511051000751 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 511051000752 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511051000753 dimer interface [polypeptide binding]; other site 511051000754 active site 511051000755 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511051000756 dimer interface [polypeptide binding]; other site 511051000757 active site 511051000758 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 511051000759 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 511051000760 active site 511051000761 dimer interface [polypeptide binding]; other site 511051000762 Protein of unknown function (DUF422); Region: DUF422; cl00991 511051000763 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 511051000764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511051000765 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 511051000766 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 511051000767 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 511051000768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051000769 Walker A/P-loop; other site 511051000770 ATP binding site [chemical binding]; other site 511051000771 Q-loop/lid; other site 511051000772 ABC transporter signature motif; other site 511051000773 Walker B; other site 511051000774 D-loop; other site 511051000775 H-loop/switch region; other site 511051000776 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 511051000777 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 511051000778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511051000779 PAS domain; Region: PAS_9; pfam13426 511051000780 putative active site [active] 511051000781 heme pocket [chemical binding]; other site 511051000782 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 511051000783 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000784 metal binding site [ion binding]; metal-binding site 511051000785 active site 511051000786 I-site; other site 511051000787 Protein of unknown function (DUF996); Region: DUF996; cl00970 511051000788 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000789 metal binding site [ion binding]; metal-binding site 511051000790 active site 511051000791 I-site; other site 511051000792 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 511051000793 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511051000794 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 511051000795 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 511051000796 putative dimer interface [polypeptide binding]; other site 511051000797 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 511051000798 16S/18S rRNA binding site [nucleotide binding]; other site 511051000799 S13e-L30e interaction site [polypeptide binding]; other site 511051000800 25S rRNA binding site [nucleotide binding]; other site 511051000801 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 511051000802 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 511051000803 RNase E interface [polypeptide binding]; other site 511051000804 trimer interface [polypeptide binding]; other site 511051000805 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 511051000806 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 511051000807 RNase E interface [polypeptide binding]; other site 511051000808 trimer interface [polypeptide binding]; other site 511051000809 active site 511051000810 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 511051000811 putative nucleic acid binding region [nucleotide binding]; other site 511051000812 G-X-X-G motif; other site 511051000813 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511051000814 RNA binding site [nucleotide binding]; other site 511051000815 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511051000816 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 511051000817 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511051000818 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 511051000819 Fe-S cluster binding site [ion binding]; other site 511051000820 active site 511051000821 protein-export membrane protein SecD; Region: secD; TIGR01129 511051000822 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 511051000823 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 511051000824 Protein export membrane protein; Region: SecD_SecF; pfam02355 511051000825 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051000826 active site 511051000827 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 511051000828 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051000829 Zn2+ binding site [ion binding]; other site 511051000830 Mg2+ binding site [ion binding]; other site 511051000831 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511051000832 synthetase active site [active] 511051000833 NTP binding site [chemical binding]; other site 511051000834 metal binding site [ion binding]; metal-binding site 511051000835 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 511051000836 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 511051000837 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511051000838 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 511051000839 putative active site [active] 511051000840 dimerization interface [polypeptide binding]; other site 511051000841 putative tRNAtyr binding site [nucleotide binding]; other site 511051000842 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 511051000843 catalytic triad [active] 511051000844 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051000845 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 511051000846 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051000847 Zn2+ binding site [ion binding]; other site 511051000848 Mg2+ binding site [ion binding]; other site 511051000849 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 511051000850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051000851 Zn2+ binding site [ion binding]; other site 511051000852 Mg2+ binding site [ion binding]; other site 511051000853 Transcriptional regulator [Transcription]; Region: LytR; COG1316 511051000854 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 511051000855 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 511051000856 replicative DNA helicase; Region: DnaB; TIGR00665 511051000857 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 511051000858 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 511051000859 Walker A motif; other site 511051000860 ATP binding site [chemical binding]; other site 511051000861 Walker B motif; other site 511051000862 DNA binding loops [nucleotide binding] 511051000863 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 511051000864 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 511051000865 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 511051000866 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 511051000867 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 511051000868 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 511051000869 dimer interface [polypeptide binding]; other site 511051000870 ssDNA binding site [nucleotide binding]; other site 511051000871 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511051000872 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 511051000873 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 511051000874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 511051000875 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 511051000876 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 511051000877 trimer interface [polypeptide binding]; other site 511051000878 putative metal binding site [ion binding]; other site 511051000879 Protein of unknown function (DUF554); Region: DUF554; pfam04474 511051000880 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511051000881 catalytic core [active] 511051000882 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511051000883 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 511051000884 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511051000885 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 511051000886 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 511051000887 Protein of unknown function DUF45; Region: DUF45; pfam01863 511051000888 hypothetical protein; Reviewed; Region: PRK00024 511051000889 hypothetical protein; Reviewed; Region: PRK00024 511051000890 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 511051000891 MPN+ (JAMM) motif; other site 511051000892 Zinc-binding site [ion binding]; other site 511051000893 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 511051000894 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 511051000895 MoaE homodimer interface [polypeptide binding]; other site 511051000896 MoaD interaction [polypeptide binding]; other site 511051000897 active site residues [active] 511051000898 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 511051000899 MoaE interaction surface [polypeptide binding]; other site 511051000900 MoeB interaction surface [polypeptide binding]; other site 511051000901 thiocarboxylated glycine; other site 511051000902 Predicted integral membrane protein [Function unknown]; Region: COG5658 511051000903 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 511051000904 SdpI/YhfL protein family; Region: SdpI; pfam13630 511051000905 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 511051000906 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 511051000907 intersubunit interface [polypeptide binding]; other site 511051000908 active site 511051000909 zinc binding site [ion binding]; other site 511051000910 Na+ binding site [ion binding]; other site 511051000911 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 511051000912 transmembrane helices; other site 511051000913 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 511051000914 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511051000915 DNA-binding site [nucleotide binding]; DNA binding site 511051000916 RNA-binding motif; other site 511051000917 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 511051000918 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 511051000919 substrate-cofactor binding pocket; other site 511051000920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051000921 catalytic residue [active] 511051000922 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051000923 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051000924 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051000925 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 511051000926 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 511051000927 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511051000928 DXD motif; other site 511051000929 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511051000930 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511051000931 Walker A/P-loop; other site 511051000932 ATP binding site [chemical binding]; other site 511051000933 Q-loop/lid; other site 511051000934 ABC transporter signature motif; other site 511051000935 Walker B; other site 511051000936 D-loop; other site 511051000937 H-loop/switch region; other site 511051000938 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 511051000939 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 511051000940 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 511051000941 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051000942 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 511051000943 VID27 cytoplasmic protein; Region: VID27; pfam08553 511051000944 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 511051000945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000946 metal binding site [ion binding]; metal-binding site 511051000947 active site 511051000948 I-site; other site 511051000949 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 511051000950 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 511051000951 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 511051000952 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051000953 metal binding site [ion binding]; metal-binding site 511051000954 active site 511051000955 I-site; other site 511051000956 GAF domain; Region: GAF; pfam01590 511051000957 HDOD domain; Region: HDOD; pfam08668 511051000958 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051000959 Zn2+ binding site [ion binding]; other site 511051000960 Mg2+ binding site [ion binding]; other site 511051000961 GTP-binding protein YchF; Reviewed; Region: PRK09601 511051000962 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 511051000963 G1 box; other site 511051000964 GTP/Mg2+ binding site [chemical binding]; other site 511051000965 G2 box; other site 511051000966 Switch I region; other site 511051000967 G3 box; other site 511051000968 Switch II region; other site 511051000969 G4 box; other site 511051000970 G5 box; other site 511051000971 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 511051000972 YtxH-like protein; Region: YtxH; pfam12732 511051000973 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 511051000974 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 511051000975 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 511051000976 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 511051000977 helix-hairpin-helix signature motif; other site 511051000978 substrate binding pocket [chemical binding]; other site 511051000979 active site 511051000980 dipeptidase PepV; Reviewed; Region: PRK07318 511051000981 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 511051000982 active site 511051000983 metal binding site [ion binding]; metal-binding site 511051000984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051000985 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 511051000986 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 511051000987 active site 511051000988 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 511051000989 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 511051000990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511051000991 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 511051000992 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511051000993 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 511051000994 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511051000995 active site 511051000996 HIGH motif; other site 511051000997 nucleotide binding site [chemical binding]; other site 511051000998 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 511051000999 active site 511051001000 KMSKS motif; other site 511051001001 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 511051001002 tRNA binding surface [nucleotide binding]; other site 511051001003 anticodon binding site; other site 511051001004 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 511051001005 Cation transport protein; Region: TrkH; pfam02386 511051001006 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 511051001007 TrkA-N domain; Region: TrkA_N; pfam02254 511051001008 TrkA-C domain; Region: TrkA_C; pfam02080 511051001009 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 511051001010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511051001011 motif II; other site 511051001012 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 511051001013 active sites [active] 511051001014 tetramer interface [polypeptide binding]; other site 511051001015 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 511051001016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 511051001017 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 511051001018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001019 dimer interface [polypeptide binding]; other site 511051001020 conserved gate region; other site 511051001021 putative PBP binding loops; other site 511051001022 ABC-ATPase subunit interface; other site 511051001023 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511051001024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001025 dimer interface [polypeptide binding]; other site 511051001026 conserved gate region; other site 511051001027 putative PBP binding loops; other site 511051001028 ABC-ATPase subunit interface; other site 511051001029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051001030 AAA domain; Region: AAA_23; pfam13476 511051001031 Walker A/P-loop; other site 511051001032 ATP binding site [chemical binding]; other site 511051001033 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 511051001034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051001035 ABC transporter signature motif; other site 511051001036 Walker B; other site 511051001037 D-loop; other site 511051001038 H-loop/switch region; other site 511051001039 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 511051001040 PSP1 C-terminal conserved region; Region: PSP1; cl00770 511051001041 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 511051001042 DNA polymerase III subunit delta'; Validated; Region: PRK08485 511051001043 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 511051001044 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 511051001045 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 511051001046 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 511051001047 CoA binding domain; Region: CoA_binding; smart00881 511051001048 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 511051001049 propionate/acetate kinase; Provisional; Region: PRK12379 511051001050 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 511051001051 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 511051001052 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051001053 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511051001054 DsrH like protein; Region: DsrH; cl17347 511051001055 DsrE/DsrF-like family; Region: DrsE; cl00672 511051001056 DsrE/DsrF-like family; Region: DrsE; cl00672 511051001057 Sulphur transport; Region: Sulf_transp; pfam04143 511051001058 Sulphur transport; Region: Sulf_transp; pfam04143 511051001059 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 511051001060 CPxP motif; other site 511051001061 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 511051001062 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 511051001063 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 511051001064 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 511051001065 hypothetical protein; Provisional; Region: PRK08378 511051001066 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 511051001067 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 511051001068 NADH dehydrogenase subunit N; Validated; Region: PRK08377 511051001069 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511051001070 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 511051001071 NADH:ubiquinone oxidoreductase subunit 1 (chain H) [Energy production and conversion]; Region: NuoH; COG1005 511051001072 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 511051001073 NADH dehydrogenase subunit B; Validated; Region: PRK06411 511051001074 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 511051001075 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 511051001076 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 511051001077 putative oxidoreductase; Provisional; Region: PRK13984 511051001078 4Fe-4S binding domain; Region: Fer4; pfam00037 511051001079 4Fe-4S binding domain; Region: Fer4; pfam00037 511051001080 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511051001081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 511051001082 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 511051001083 protein-splicing catalytic site; other site 511051001084 thioester formation/cholesterol transfer; other site 511051001085 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 511051001086 dihydropteroate synthase; Region: DHPS; TIGR01496 511051001087 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 511051001088 substrate binding pocket [chemical binding]; other site 511051001089 dimer interface [polypeptide binding]; other site 511051001090 inhibitor binding site; inhibition site 511051001091 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 511051001092 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 511051001093 catalytic center binding site [active] 511051001094 ATP binding site [chemical binding]; other site 511051001095 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 511051001096 putative catalytic site [active] 511051001097 putative phosphate binding site [ion binding]; other site 511051001098 active site 511051001099 metal binding site A [ion binding]; metal-binding site 511051001100 DNA binding site [nucleotide binding] 511051001101 putative AP binding site [nucleotide binding]; other site 511051001102 putative metal binding site B [ion binding]; other site 511051001103 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 511051001104 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 511051001105 active site 511051001106 dimerization interface [polypeptide binding]; other site 511051001107 EDD domain protein, DegV family; Region: DegV; TIGR00762 511051001108 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511051001109 Domain of unknown function (DUF348); Region: DUF348; pfam03990 511051001110 G5 domain; Region: G5; pfam07501 511051001111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 511051001112 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 511051001113 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 511051001114 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 511051001115 lipoyl attachment site [posttranslational modification]; other site 511051001116 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 511051001117 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 511051001118 tetramer interface [polypeptide binding]; other site 511051001119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001120 catalytic residue [active] 511051001121 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 511051001122 tetramer interface [polypeptide binding]; other site 511051001123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001124 catalytic residue [active] 511051001125 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 511051001126 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 511051001127 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 511051001128 active site 511051001129 HIGH motif; other site 511051001130 KMSK motif region; other site 511051001131 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511051001132 tRNA binding surface [nucleotide binding]; other site 511051001133 anticodon binding site; other site 511051001134 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 511051001135 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511051001136 active site 511051001137 O-Antigen ligase; Region: Wzy_C; cl04850 511051001138 O-Antigen ligase; Region: Wzy_C; pfam04932 511051001139 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 511051001140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511051001141 putative homodimer interface [polypeptide binding]; other site 511051001142 integral membrane protein MviN; Region: mviN; TIGR01695 511051001143 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 511051001144 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 511051001145 cytidylate kinase; Provisional; Region: cmk; PRK00023 511051001146 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 511051001147 CMP-binding site; other site 511051001148 The sites determining sugar specificity; other site 511051001149 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 511051001150 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511051001151 putative acyl-acceptor binding pocket; other site 511051001152 LytB protein; Region: LYTB; cl00507 511051001153 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 511051001154 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 511051001155 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 511051001156 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511051001157 active site 511051001158 catalytic tetrad [active] 511051001159 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511051001160 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 511051001161 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 511051001162 FeoA domain; Region: FeoA; pfam04023 511051001163 FeoA domain; Region: FeoA; pfam04023 511051001164 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 511051001165 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 511051001166 G1 box; other site 511051001167 GTP/Mg2+ binding site [chemical binding]; other site 511051001168 Switch I region; other site 511051001169 G2 box; other site 511051001170 G3 box; other site 511051001171 Switch II region; other site 511051001172 G4 box; other site 511051001173 G5 box; other site 511051001174 Nucleoside recognition; Region: Gate; pfam07670 511051001175 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 511051001176 Nucleoside recognition; Region: Gate; pfam07670 511051001177 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 511051001178 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 511051001179 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 511051001180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001181 dimer interface [polypeptide binding]; other site 511051001182 conserved gate region; other site 511051001183 putative PBP binding loops; other site 511051001184 ABC-ATPase subunit interface; other site 511051001185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051001186 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 511051001187 Walker A/P-loop; other site 511051001188 ATP binding site [chemical binding]; other site 511051001189 Q-loop/lid; other site 511051001190 ABC transporter signature motif; other site 511051001191 Walker B; other site 511051001192 D-loop; other site 511051001193 H-loop/switch region; other site 511051001194 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 511051001195 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 511051001196 MPT binding site; other site 511051001197 Domain of unknown function (DUF364); Region: DUF364; pfam04016 511051001198 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 511051001199 integral membrane protein MviN; Region: mviN; TIGR01695 511051001200 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 511051001201 TIGR00159 family protein; Region: TIGR00159 511051001202 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 511051001203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 511051001204 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 511051001205 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 511051001206 active site 511051001207 DNA binding site [nucleotide binding] 511051001208 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 511051001209 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 511051001210 RNA binding site [nucleotide binding]; other site 511051001211 active site 511051001212 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 511051001213 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 511051001214 active site 511051001215 Riboflavin kinase; Region: Flavokinase; pfam01687 511051001216 Protein of unknown function DUF262; Region: DUF262; pfam03235 511051001217 Uncharacterized conserved protein [Function unknown]; Region: COG1479 511051001218 Uncharacterized conserved protein [Function unknown]; Region: COG3472 511051001219 HsdM N-terminal domain; Region: HsdM_N; pfam12161 511051001220 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 511051001221 probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316 511051001222 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511051001223 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511051001224 peptidase; Reviewed; Region: PRK13004 511051001225 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 511051001226 putative metal binding site [ion binding]; other site 511051001227 putative dimer interface [polypeptide binding]; other site 511051001228 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 511051001229 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 511051001230 putative substrate binding site [chemical binding]; other site 511051001231 nucleotide binding site [chemical binding]; other site 511051001232 nucleotide binding site [chemical binding]; other site 511051001233 homodimer interface [polypeptide binding]; other site 511051001234 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 511051001235 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 511051001236 motif 1; other site 511051001237 active site 511051001238 motif 2; other site 511051001239 motif 3; other site 511051001240 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 511051001241 Sec34-like family; Region: Sec34; pfam04136 511051001242 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 511051001243 YceG-like family; Region: YceG; pfam02618 511051001244 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 511051001245 dimerization interface [polypeptide binding]; other site 511051001246 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 511051001247 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 511051001248 Threonine dehydrogenase; Region: TDH; cd05281 511051001249 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 511051001250 structural Zn binding site [ion binding]; other site 511051001251 catalytic Zn binding site [ion binding]; other site 511051001252 tetramer interface [polypeptide binding]; other site 511051001253 NADP binding site [chemical binding]; other site 511051001254 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 511051001255 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 511051001256 substrate-cofactor binding pocket; other site 511051001257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001258 catalytic residue [active] 511051001259 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 511051001260 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 511051001261 Substrate binding site; other site 511051001262 Mg++ binding site; other site 511051001263 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 511051001264 active site 511051001265 substrate binding site [chemical binding]; other site 511051001266 CoA binding site [chemical binding]; other site 511051001267 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 511051001268 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511051001269 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051001270 active site 511051001271 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 511051001272 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 511051001273 5S rRNA interface [nucleotide binding]; other site 511051001274 CTC domain interface [polypeptide binding]; other site 511051001275 L16 interface [polypeptide binding]; other site 511051001276 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 511051001277 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051001278 putative active site [active] 511051001279 metal binding site [ion binding]; metal-binding site 511051001280 homodimer binding site [polypeptide binding]; other site 511051001281 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 511051001282 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 511051001283 metal binding triad [ion binding]; metal-binding site 511051001284 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 511051001285 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511051001286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001287 FeS/SAM binding site; other site 511051001288 TRAM domain; Region: TRAM; pfam01938 511051001289 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 511051001290 ScpA/B protein; Region: ScpA_ScpB; cl00598 511051001291 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 511051001292 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 511051001293 active site 511051001294 HIGH motif; other site 511051001295 dimer interface [polypeptide binding]; other site 511051001296 KMSKS motif; other site 511051001297 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 511051001298 Peptidase family M50; Region: Peptidase_M50; pfam02163 511051001299 active site 511051001300 putative substrate binding region [chemical binding]; other site 511051001301 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 511051001302 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 511051001303 Aluminium resistance protein; Region: Alum_res; pfam06838 511051001304 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 511051001305 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 511051001306 spermidine synthase; Provisional; Region: PRK00811 511051001307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051001308 S-adenosylmethionine binding site [chemical binding]; other site 511051001309 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 511051001310 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 511051001311 active site 511051001312 putative substrate binding pocket [chemical binding]; other site 511051001313 Thiamine pyrophosphokinase; Region: TPK; cd07995 511051001314 active site 511051001315 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 511051001316 dimerization interface [polypeptide binding]; other site 511051001317 thiamine binding site [chemical binding]; other site 511051001318 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 511051001319 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051001320 active site 511051001321 metal binding site [ion binding]; metal-binding site 511051001322 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511051001323 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 511051001324 active site 511051001325 intersubunit interactions; other site 511051001326 catalytic residue [active] 511051001327 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 511051001328 TPP-binding site [chemical binding]; other site 511051001329 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 511051001330 PYR/PP interface [polypeptide binding]; other site 511051001331 dimer interface [polypeptide binding]; other site 511051001332 TPP binding site [chemical binding]; other site 511051001333 Haemolysin-III related; Region: HlyIII; cl03831 511051001334 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 511051001335 Methyltransferase domain; Region: Methyltransf_23; pfam13489 511051001336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051001337 S-adenosylmethionine binding site [chemical binding]; other site 511051001338 Domain of unknown function DUF77; Region: DUF77; pfam01910 511051001339 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 511051001340 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 511051001341 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 511051001342 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 511051001343 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 511051001344 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 511051001345 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 511051001346 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051001347 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051001348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 511051001349 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 511051001350 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511051001351 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511051001352 Walker A/P-loop; other site 511051001353 ATP binding site [chemical binding]; other site 511051001354 Q-loop/lid; other site 511051001355 ABC transporter signature motif; other site 511051001356 Walker B; other site 511051001357 D-loop; other site 511051001358 H-loop/switch region; other site 511051001359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001360 dimer interface [polypeptide binding]; other site 511051001361 conserved gate region; other site 511051001362 putative PBP binding loops; other site 511051001363 ABC-ATPase subunit interface; other site 511051001364 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 511051001365 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511051001366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511051001367 substrate binding pocket [chemical binding]; other site 511051001368 membrane-bound complex binding site; other site 511051001369 hinge residues; other site 511051001370 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 511051001371 active site 511051001372 EDD domain protein, DegV family; Region: DegV; TIGR00762 511051001373 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511051001374 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 511051001375 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 511051001376 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051001377 RmuC family; Region: RmuC; pfam02646 511051001378 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 511051001379 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 511051001380 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511051001381 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 511051001382 active site 511051001383 catalytic site [active] 511051001384 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511051001385 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511051001386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051001387 Walker A/P-loop; other site 511051001388 ATP binding site [chemical binding]; other site 511051001389 Q-loop/lid; other site 511051001390 ABC transporter signature motif; other site 511051001391 Walker B; other site 511051001392 D-loop; other site 511051001393 H-loop/switch region; other site 511051001394 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511051001395 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 511051001396 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511051001397 Walker A/P-loop; other site 511051001398 ATP binding site [chemical binding]; other site 511051001399 Q-loop/lid; other site 511051001400 ABC transporter signature motif; other site 511051001401 Walker B; other site 511051001402 D-loop; other site 511051001403 H-loop/switch region; other site 511051001404 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001405 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 511051001406 FeS/SAM binding site; other site 511051001407 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 511051001408 short chain dehydrogenase; Provisional; Region: PRK06197 511051001409 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 511051001410 putative NAD(P) binding site [chemical binding]; other site 511051001411 active site 511051001412 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 511051001413 threonine synthase; Validated; Region: PRK06260 511051001414 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 511051001415 homodimer interface [polypeptide binding]; other site 511051001416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001417 catalytic residue [active] 511051001418 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 511051001419 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 511051001420 putative catalytic residues [active] 511051001421 nucleotide binding site [chemical binding]; other site 511051001422 aspartate binding site [chemical binding]; other site 511051001423 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 511051001424 dimer interface [polypeptide binding]; other site 511051001425 putative threonine allosteric regulatory site; other site 511051001426 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 511051001427 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 511051001428 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 511051001429 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 511051001430 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 511051001431 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 511051001432 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511051001433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001434 homodimer interface [polypeptide binding]; other site 511051001435 catalytic residue [active] 511051001436 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 511051001437 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 511051001438 intersubunit interface [polypeptide binding]; other site 511051001439 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 511051001440 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 511051001441 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 511051001442 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511051001443 ABC-ATPase subunit interface; other site 511051001444 dimer interface [polypeptide binding]; other site 511051001445 putative PBP binding regions; other site 511051001446 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 511051001447 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 511051001448 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511051001449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001450 FeS/SAM binding site; other site 511051001451 TRAM domain; Region: TRAM; cl01282 511051001452 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 511051001453 active site 511051001454 tetramer interface; other site 511051001455 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 511051001456 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051001457 putative active site [active] 511051001458 putative metal binding site [ion binding]; other site 511051001459 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 511051001460 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 511051001461 homotetramer interface [polypeptide binding]; other site 511051001462 ligand binding site [chemical binding]; other site 511051001463 catalytic site [active] 511051001464 NAD binding site [chemical binding]; other site 511051001465 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 511051001466 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 511051001467 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 511051001468 homodimer interface [polypeptide binding]; other site 511051001469 NADP binding site [chemical binding]; other site 511051001470 substrate binding site [chemical binding]; other site 511051001471 HerA helicase [Replication, recombination, and repair]; Region: COG0433 511051001472 Domain of unknown function DUF87; Region: DUF87; pfam01935 511051001473 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 511051001474 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 511051001475 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 511051001476 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051001477 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051001478 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 511051001479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 511051001480 TPR motif; other site 511051001481 binding surface 511051001482 Uncharacterized conserved protein [Function unknown]; Region: COG0062 511051001483 putative carbohydrate kinase; Provisional; Region: PRK10565 511051001484 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 511051001485 putative substrate binding site [chemical binding]; other site 511051001486 putative ATP binding site [chemical binding]; other site 511051001487 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 511051001488 Predicted methyltransferases [General function prediction only]; Region: COG1568 511051001489 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 511051001490 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 511051001491 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 511051001492 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 511051001493 Divergent PAP2 family; Region: DUF212; pfam02681 511051001494 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 511051001495 Ligand Binding Site [chemical binding]; other site 511051001496 EamA-like transporter family; Region: EamA; pfam00892 511051001497 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 511051001498 EamA-like transporter family; Region: EamA; pfam00892 511051001499 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 511051001500 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511051001501 Signal peptide binding domain; Region: SRP_SPB; pfam02978 511051001502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 511051001503 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 511051001504 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 511051001505 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511051001506 ribonuclease III; Reviewed; Region: rnc; PRK00102 511051001507 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 511051001508 dimerization interface [polypeptide binding]; other site 511051001509 active site 511051001510 metal binding site [ion binding]; metal-binding site 511051001511 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 511051001512 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 511051001513 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 511051001514 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 511051001515 HIGH motif; other site 511051001516 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511051001517 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511051001518 active site 511051001519 KMSKS motif; other site 511051001520 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 511051001521 tRNA binding surface [nucleotide binding]; other site 511051001522 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 511051001523 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 511051001524 glutaminase active site [active] 511051001525 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511051001526 dimer interface [polypeptide binding]; other site 511051001527 active site 511051001528 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511051001529 dimer interface [polypeptide binding]; other site 511051001530 active site 511051001531 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 511051001532 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 511051001533 active site 511051001534 substrate binding site [chemical binding]; other site 511051001535 metal binding site [ion binding]; metal-binding site 511051001536 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 511051001537 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 511051001538 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 511051001539 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 511051001540 GAF domain; Region: GAF_3; pfam13492 511051001541 Histidine kinase; Region: His_kinase; pfam06580 511051001542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051001543 ATP binding site [chemical binding]; other site 511051001544 Mg2+ binding site [ion binding]; other site 511051001545 G-X-G motif; other site 511051001546 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 511051001547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051001548 active site 511051001549 phosphorylation site [posttranslational modification] 511051001550 intermolecular recognition site; other site 511051001551 dimerization interface [polypeptide binding]; other site 511051001552 LytTr DNA-binding domain; Region: LytTR; pfam04397 511051001553 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 511051001554 Carbon starvation protein CstA; Region: CstA; pfam02554 511051001555 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 511051001556 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 511051001557 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 511051001558 P loop; other site 511051001559 Nucleotide binding site [chemical binding]; other site 511051001560 DTAP/Switch II; other site 511051001561 Switch I; other site 511051001562 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511051001563 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 511051001564 active site 511051001565 metal binding site [ion binding]; metal-binding site 511051001566 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 511051001567 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 511051001568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511051001569 inhibitor-cofactor binding pocket; inhibition site 511051001570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001571 catalytic residue [active] 511051001572 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 511051001573 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 511051001574 Ligand Binding Site [chemical binding]; other site 511051001575 Domain of unknown function (DUF814); Region: DUF814; pfam05670 511051001576 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 511051001577 active site 511051001578 dimer interface [polypeptide binding]; other site 511051001579 catalytic nucleophile [active] 511051001580 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 511051001581 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 511051001582 PhoU domain; Region: PhoU; pfam01895 511051001583 PhoU domain; Region: PhoU; pfam01895 511051001584 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 511051001585 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 511051001586 Walker A/P-loop; other site 511051001587 ATP binding site [chemical binding]; other site 511051001588 Q-loop/lid; other site 511051001589 ABC transporter signature motif; other site 511051001590 Walker B; other site 511051001591 D-loop; other site 511051001592 H-loop/switch region; other site 511051001593 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 511051001594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001595 dimer interface [polypeptide binding]; other site 511051001596 conserved gate region; other site 511051001597 putative PBP binding loops; other site 511051001598 ABC-ATPase subunit interface; other site 511051001599 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 511051001600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051001601 dimer interface [polypeptide binding]; other site 511051001602 conserved gate region; other site 511051001603 putative PBP binding loops; other site 511051001604 ABC-ATPase subunit interface; other site 511051001605 PBP superfamily domain; Region: PBP_like_2; cl17296 511051001606 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 511051001607 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 511051001608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051001609 dimer interface [polypeptide binding]; other site 511051001610 phosphorylation site [posttranslational modification] 511051001611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051001612 ATP binding site [chemical binding]; other site 511051001613 Mg2+ binding site [ion binding]; other site 511051001614 G-X-G motif; other site 511051001615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511051001616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051001617 active site 511051001618 phosphorylation site [posttranslational modification] 511051001619 intermolecular recognition site; other site 511051001620 dimerization interface [polypeptide binding]; other site 511051001621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511051001622 DNA binding site [nucleotide binding] 511051001623 Protein of unknown function (DUF763); Region: DUF763; pfam05559 511051001624 Uncharacterized conserved protein [Function unknown]; Region: COG1739 511051001625 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 511051001626 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 511051001627 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 511051001628 KH domain; Region: KH_4; pfam13083 511051001629 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 511051001630 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 511051001631 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 511051001632 EamA-like transporter family; Region: EamA; pfam00892 511051001633 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 511051001634 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 511051001635 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511051001636 Catalytic site [active] 511051001637 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 511051001638 RNA/DNA hybrid binding site [nucleotide binding]; other site 511051001639 active site 511051001640 hypothetical protein; Reviewed; Region: PRK12497 511051001641 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511051001642 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511051001643 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511051001644 phosphodiesterase YaeI; Provisional; Region: PRK11340 511051001645 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 511051001646 putative active site [active] 511051001647 putative metal binding site [ion binding]; other site 511051001648 LexA repressor; Validated; Region: PRK00215 511051001649 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 511051001650 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511051001651 Catalytic site [active] 511051001652 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 511051001653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001654 Walker A motif; other site 511051001655 ATP binding site [chemical binding]; other site 511051001656 Isochorismatase family; Region: Isochorismatase; pfam00857 511051001657 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511051001658 catalytic triad [active] 511051001659 conserved cis-peptide bond; other site 511051001660 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 511051001661 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 511051001662 catalytic triad [active] 511051001663 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 511051001664 putative active site pocket [active] 511051001665 cleavage site 511051001666 OPT oligopeptide transporter protein; Region: OPT; cl14607 511051001667 OPT oligopeptide transporter protein; Region: OPT; cl14607 511051001668 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 511051001669 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 511051001670 nucleotide binding pocket [chemical binding]; other site 511051001671 K-X-D-G motif; other site 511051001672 catalytic site [active] 511051001673 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 511051001674 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 511051001675 Helix-hairpin-helix motif; Region: HHH; pfam00633 511051001676 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 511051001677 Dimer interface [polypeptide binding]; other site 511051001678 BRCT sequence motif; other site 511051001679 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 511051001680 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 511051001681 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 511051001682 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 511051001683 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 511051001684 GatB domain; Region: GatB_Yqey; pfam02637 511051001685 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 511051001686 putative FMN binding site [chemical binding]; other site 511051001687 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 511051001688 Peptidase family M48; Region: Peptidase_M48; cl12018 511051001689 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 511051001690 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 511051001691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 511051001692 active site 511051001693 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 511051001694 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 511051001695 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 511051001696 asparagine synthetase A; Reviewed; Region: PRK06462 511051001697 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511051001698 motif 1; other site 511051001699 dimer interface [polypeptide binding]; other site 511051001700 active site 511051001701 motif 2; other site 511051001702 motif 3; other site 511051001703 Domain of unknown function DUF20; Region: UPF0118; pfam01594 511051001704 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 511051001705 DNA gyrase subunit A; Validated; Region: PRK05560 511051001706 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 511051001707 CAP-like domain; other site 511051001708 active site 511051001709 primary dimer interface [polypeptide binding]; other site 511051001710 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001711 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001712 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001713 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001714 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511051001715 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 511051001716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051001717 Mg2+ binding site [ion binding]; other site 511051001718 G-X-G motif; other site 511051001719 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511051001720 anchoring element; other site 511051001721 dimer interface [polypeptide binding]; other site 511051001722 ATP binding site [chemical binding]; other site 511051001723 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511051001724 active site 511051001725 putative metal-binding site [ion binding]; other site 511051001726 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511051001727 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 511051001728 Clp amino terminal domain; Region: Clp_N; pfam02861 511051001729 Clp amino terminal domain; Region: Clp_N; pfam02861 511051001730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001731 Walker A motif; other site 511051001732 ATP binding site [chemical binding]; other site 511051001733 Walker B motif; other site 511051001734 arginine finger; other site 511051001735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001736 Walker A motif; other site 511051001737 ATP binding site [chemical binding]; other site 511051001738 Walker B motif; other site 511051001739 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511051001740 GTP-binding protein LepA; Provisional; Region: PRK05433 511051001741 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 511051001742 G1 box; other site 511051001743 putative GEF interaction site [polypeptide binding]; other site 511051001744 GTP/Mg2+ binding site [chemical binding]; other site 511051001745 Switch I region; other site 511051001746 G2 box; other site 511051001747 G3 box; other site 511051001748 Switch II region; other site 511051001749 G4 box; other site 511051001750 G5 box; other site 511051001751 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 511051001752 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 511051001753 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 511051001754 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 511051001755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001756 FeS/SAM binding site; other site 511051001757 HemN C-terminal domain; Region: HemN_C; pfam06969 511051001758 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051001759 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 511051001760 shikimate kinase; Reviewed; Region: aroK; PRK00131 511051001761 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 511051001762 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 511051001763 phosphate binding site [ion binding]; other site 511051001764 putative substrate binding pocket [chemical binding]; other site 511051001765 dimer interface [polypeptide binding]; other site 511051001766 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 511051001767 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 511051001768 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 511051001769 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 511051001770 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 511051001771 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 511051001772 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 511051001773 Phosphoglycerate kinase; Region: PGK; pfam00162 511051001774 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 511051001775 substrate binding site [chemical binding]; other site 511051001776 hinge regions; other site 511051001777 ADP binding site [chemical binding]; other site 511051001778 catalytic site [active] 511051001779 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051001780 Preprotein translocase SecG subunit; Region: SecG; pfam03840 511051001781 potential protein location (hypothetical protein CSE_06520 [Caldisericum exile AZM16c01]) that overlaps RNA (tRNA-F) 511051001782 potential frameshift: common BLAST hit: gi|20808813|ref|NP_623984.1| major facilitator superfamily permease 511051001783 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051001784 Transmembrane secretion effector; Region: MFS_3; pfam05977 511051001785 Chromate transporter; Region: Chromate_transp; pfam02417 511051001786 Chromate transporter; Region: Chromate_transp; pfam02417 511051001787 Chromate transporter; Region: Chromate_transp; pfam02417 511051001788 CARDB; Region: CARDB; pfam07705 511051001789 CARDB; Region: CARDB; pfam07705 511051001790 Uncharacterized conserved protein [Function unknown]; Region: COG1572 511051001791 CARDB; Region: CARDB; pfam07705 511051001792 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 511051001793 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 511051001794 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511051001795 Caspase domain; Region: Peptidase_C14; pfam00656 511051001796 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 511051001797 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 511051001798 active site 511051001799 homotetramer interface [polypeptide binding]; other site 511051001800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511051001801 active site 511051001802 motif I; other site 511051001803 motif II; other site 511051001804 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK04210 511051001805 active site 511051001806 metal-binding site [ion binding] 511051001807 nucleotide-binding site [chemical binding]; other site 511051001808 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 511051001809 putative ligand binding pocket/active site [active] 511051001810 putative metal binding site [ion binding]; other site 511051001811 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 511051001812 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 511051001813 putative active site [active] 511051001814 putative metal binding site [ion binding]; other site 511051001815 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 511051001816 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 511051001817 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511051001818 active site 511051001819 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 511051001820 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 511051001821 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 511051001822 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 511051001823 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511051001824 catalytic loop [active] 511051001825 iron binding site [ion binding]; other site 511051001826 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 511051001827 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 511051001828 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 511051001829 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 511051001830 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 511051001831 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 511051001832 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 511051001833 RNA binding site [nucleotide binding]; other site 511051001834 Septum formation initiator; Region: DivIC; cl17659 511051001835 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 511051001836 4Fe-4S binding domain; Region: Fer4; cl02805 511051001837 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 511051001838 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 511051001839 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 511051001840 4Fe-4S binding domain; Region: Fer4; cl02805 511051001841 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511051001842 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 511051001843 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051001844 dimer interface [polypeptide binding]; other site 511051001845 PYR/PP interface [polypeptide binding]; other site 511051001846 TPP binding site [chemical binding]; other site 511051001847 substrate binding site [chemical binding]; other site 511051001848 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511051001849 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 511051001850 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 511051001851 TPP-binding site [chemical binding]; other site 511051001852 putative dimer interface [polypeptide binding]; other site 511051001853 Plasmodium yoelii subtelomeric domain PYST-C2; Region: PYST-C2; TIGR01604 511051001854 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 511051001855 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 511051001856 GrpE; Region: GrpE; pfam01025 511051001857 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 511051001858 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 511051001859 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 511051001860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 511051001861 nucleotide binding site [chemical binding]; other site 511051001862 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 511051001863 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511051001864 HSP70 interaction site [polypeptide binding]; other site 511051001865 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 511051001866 substrate binding site [polypeptide binding]; other site 511051001867 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 511051001868 Zn binding sites [ion binding]; other site 511051001869 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 511051001870 dimer interface [polypeptide binding]; other site 511051001871 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 511051001872 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 511051001873 domain interfaces; other site 511051001874 active site 511051001875 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 511051001876 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 511051001877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051001878 H+ Antiporter protein; Region: 2A0121; TIGR00900 511051001879 putative substrate translocation pore; other site 511051001880 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 511051001881 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 511051001882 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 511051001883 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051001884 Zn2+ binding site [ion binding]; other site 511051001885 Mg2+ binding site [ion binding]; other site 511051001886 hypothetical protein; Provisional; Region: PRK08609 511051001887 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 511051001888 active site 511051001889 primer binding site [nucleotide binding]; other site 511051001890 NTP binding site [chemical binding]; other site 511051001891 metal binding triad [ion binding]; metal-binding site 511051001892 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 511051001893 active site 511051001894 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 511051001895 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511051001896 substrate binding site [chemical binding]; other site 511051001897 ATP binding site [chemical binding]; other site 511051001898 excinuclease ABC subunit B; Provisional; Region: PRK05298 511051001899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051001900 ATP binding site [chemical binding]; other site 511051001901 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051001902 nucleotide binding region [chemical binding]; other site 511051001903 ATP-binding site [chemical binding]; other site 511051001904 Ultra-violet resistance protein B; Region: UvrB; pfam12344 511051001905 UvrB/uvrC motif; Region: UVR; pfam02151 511051001906 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 511051001907 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 511051001908 active site 511051001909 nucleophile elbow; other site 511051001910 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 511051001911 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511051001912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051001913 homodimer interface [polypeptide binding]; other site 511051001914 catalytic residue [active] 511051001915 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 511051001916 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 511051001917 Moco binding site; other site 511051001918 metal coordination site [ion binding]; other site 511051001919 putative phosphate acyltransferase; Provisional; Region: PRK05331 511051001920 EDD domain protein, DegV family; Region: DegV; TIGR00762 511051001921 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511051001922 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 511051001923 hypothetical protein; Reviewed; Region: PRK09588 511051001924 endonuclease IV; Provisional; Region: PRK01060 511051001925 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 511051001926 AP (apurinic/apyrimidinic) site pocket; other site 511051001927 DNA interaction; other site 511051001928 Metal-binding active site; metal-binding site 511051001929 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 511051001930 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511051001931 catalytic residue [active] 511051001932 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 511051001933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001934 FeS/SAM binding site; other site 511051001935 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 511051001936 membrane protein FdrA; Validated; Region: PRK06091 511051001937 CoA-ligase; Region: Ligase_CoA; pfam00549 511051001938 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 511051001939 Putative cyclase; Region: Cyclase; pfam04199 511051001940 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 511051001941 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 511051001942 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 511051001943 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511051001944 catalytic loop [active] 511051001945 iron binding site [ion binding]; other site 511051001946 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 511051001947 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 511051001948 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 511051001949 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 511051001950 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 511051001951 trigger factor; Region: tig; TIGR00115 511051001952 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 511051001953 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 511051001954 Clp protease; Region: CLP_protease; pfam00574 511051001955 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 511051001956 oligomer interface [polypeptide binding]; other site 511051001957 active site residues [active] 511051001958 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 511051001959 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 511051001960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001961 Walker A motif; other site 511051001962 ATP binding site [chemical binding]; other site 511051001963 Walker B motif; other site 511051001964 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 511051001965 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 511051001966 Found in ATP-dependent protease La (LON); Region: LON; smart00464 511051001967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051001968 Walker A motif; other site 511051001969 ATP binding site [chemical binding]; other site 511051001970 Walker B motif; other site 511051001971 arginine finger; other site 511051001972 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 511051001973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511051001974 non-specific DNA binding site [nucleotide binding]; other site 511051001975 salt bridge; other site 511051001976 sequence-specific DNA binding site [nucleotide binding]; other site 511051001977 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 511051001978 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 511051001979 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 511051001980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051001981 FeS/SAM binding site; other site 511051001982 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 511051001983 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 511051001984 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 511051001985 recombinase A; Provisional; Region: recA; PRK09354 511051001986 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 511051001987 hexamer interface [polypeptide binding]; other site 511051001988 Walker A motif; other site 511051001989 ATP binding site [chemical binding]; other site 511051001990 Walker B motif; other site 511051001991 recombination regulator RecX; Reviewed; Region: recX; PRK00117 511051001992 phosphodiesterase; Provisional; Region: PRK12704 511051001993 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051001994 Zn2+ binding site [ion binding]; other site 511051001995 Mg2+ binding site [ion binding]; other site 511051001996 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 511051001997 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 511051001998 GIY-YIG motif/motif A; other site 511051001999 active site 511051002000 catalytic site [active] 511051002001 putative DNA binding site [nucleotide binding]; other site 511051002002 metal binding site [ion binding]; metal-binding site 511051002003 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 511051002004 Membrane protein of unknown function; Region: DUF360; pfam04020 511051002005 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 511051002006 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 511051002007 HflX GTPase family; Region: HflX; cd01878 511051002008 G1 box; other site 511051002009 GTP/Mg2+ binding site [chemical binding]; other site 511051002010 Switch I region; other site 511051002011 G2 box; other site 511051002012 G3 box; other site 511051002013 Switch II region; other site 511051002014 G4 box; other site 511051002015 G5 box; other site 511051002016 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 511051002017 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 511051002018 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 511051002019 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 511051002020 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 511051002021 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 511051002022 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 511051002023 putative ligand binding site [chemical binding]; other site 511051002024 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051002025 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 511051002026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511051002027 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511051002028 nucleotide binding site [chemical binding]; other site 511051002029 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 511051002030 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 511051002031 dimer interface [polypeptide binding]; other site 511051002032 anticodon binding site; other site 511051002033 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 511051002034 homodimer interface [polypeptide binding]; other site 511051002035 motif 1; other site 511051002036 active site 511051002037 motif 2; other site 511051002038 GAD domain; Region: GAD; pfam02938 511051002039 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511051002040 active site 511051002041 motif 3; other site 511051002042 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 511051002043 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 511051002044 dimer interface [polypeptide binding]; other site 511051002045 motif 1; other site 511051002046 active site 511051002047 motif 2; other site 511051002048 motif 3; other site 511051002049 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 511051002050 anticodon binding site; other site 511051002051 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 511051002052 dinuclear metal binding motif [ion binding]; other site 511051002053 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 511051002054 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 511051002055 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 511051002056 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 511051002057 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 511051002058 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 511051002059 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511051002060 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 511051002061 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 511051002062 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511051002063 hinge; other site 511051002064 active site 511051002065 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 511051002066 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 511051002067 active site 511051002068 homodimer interface [polypeptide binding]; other site 511051002069 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 511051002070 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 511051002071 Mg++ binding site [ion binding]; other site 511051002072 putative catalytic motif [active] 511051002073 substrate binding site [chemical binding]; other site 511051002074 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051002075 active site 511051002076 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 511051002077 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 511051002078 dimer interface [polypeptide binding]; other site 511051002079 active site 511051002080 glycine-pyridoxal phosphate binding site [chemical binding]; other site 511051002081 folate binding site [chemical binding]; other site 511051002082 comF family protein; Region: comF; TIGR00201 511051002083 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051002084 active site 511051002085 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 511051002086 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 511051002087 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 511051002088 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 511051002089 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 511051002090 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 511051002091 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 511051002092 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 511051002093 NAD(P) binding site [chemical binding]; other site 511051002094 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 511051002095 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 511051002096 urocanate hydratase; Provisional; Region: PRK05414 511051002097 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 511051002098 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511051002099 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511051002100 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511051002101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511051002102 motif II; other site 511051002103 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511051002104 Ubiquitin-like proteins; Region: UBQ; cl00155 511051002105 charged pocket; other site 511051002106 hydrophobic patch; other site 511051002107 PEGA domain; Region: PEGA; pfam08308 511051002108 PEGA domain; Region: PEGA; pfam08308 511051002109 PEGA domain; Region: PEGA; pfam08308 511051002110 PEGA domain; Region: PEGA; pfam08308 511051002111 thymidylate kinase; Validated; Region: tmk; PRK00698 511051002112 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 511051002113 TMP-binding site; other site 511051002114 ATP-binding site [chemical binding]; other site 511051002115 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 511051002116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051002117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002118 Walker A motif; other site 511051002119 Walker A/P-loop; other site 511051002120 ATP binding site [chemical binding]; other site 511051002121 ATP binding site [chemical binding]; other site 511051002122 Walker B motif; other site 511051002123 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 511051002124 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 511051002125 Substrate-binding site [chemical binding]; other site 511051002126 Substrate specificity [chemical binding]; other site 511051002127 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 511051002128 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 511051002129 SurA N-terminal domain; Region: SurA_N_3; cl07813 511051002130 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 511051002131 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 511051002132 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511051002133 phosphopentomutase; Provisional; Region: PRK05362 511051002134 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 511051002135 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 511051002136 Y-family of DNA polymerases; Region: PolY; cl12025 511051002137 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 511051002138 ssDNA binding site; other site 511051002139 generic binding surface II; other site 511051002140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051002141 ATP binding site [chemical binding]; other site 511051002142 putative Mg++ binding site [ion binding]; other site 511051002143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051002144 nucleotide binding region [chemical binding]; other site 511051002145 ATP-binding site [chemical binding]; other site 511051002146 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 511051002147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051002148 S-adenosylmethionine binding site [chemical binding]; other site 511051002149 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 511051002150 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 511051002151 dimer interface [polypeptide binding]; other site 511051002152 putative functional site; other site 511051002153 putative MPT binding site; other site 511051002154 PBP superfamily domain; Region: PBP_like; pfam12727 511051002155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051002156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051002157 putative substrate translocation pore; other site 511051002158 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 511051002159 MoxR-like ATPases [General function prediction only]; Region: COG0714 511051002160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002161 Walker A motif; other site 511051002162 ATP binding site [chemical binding]; other site 511051002163 Walker B motif; other site 511051002164 arginine finger; other site 511051002165 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 511051002166 Protein of unknown function DUF58; Region: DUF58; pfam01882 511051002167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511051002168 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 511051002169 dimerization interface [polypeptide binding]; other site 511051002170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051002171 dimer interface [polypeptide binding]; other site 511051002172 phosphorylation site [posttranslational modification] 511051002173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051002174 ATP binding site [chemical binding]; other site 511051002175 Mg2+ binding site [ion binding]; other site 511051002176 G-X-G motif; other site 511051002177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511051002178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051002179 active site 511051002180 phosphorylation site [posttranslational modification] 511051002181 intermolecular recognition site; other site 511051002182 dimerization interface [polypeptide binding]; other site 511051002183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511051002184 DNA binding site [nucleotide binding] 511051002185 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 511051002186 elongation factor P; Validated; Region: PRK00529 511051002187 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 511051002188 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 511051002189 RNA binding site [nucleotide binding]; other site 511051002190 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 511051002191 RNA binding site [nucleotide binding]; other site 511051002192 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 511051002193 putative RNA binding site [nucleotide binding]; other site 511051002194 Acylphosphatase; Region: Acylphosphatase; pfam00708 511051002195 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 511051002196 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511051002197 substrate binding pocket [chemical binding]; other site 511051002198 chain length determination region; other site 511051002199 substrate-Mg2+ binding site; other site 511051002200 catalytic residues [active] 511051002201 aspartate-rich region 1; other site 511051002202 active site lid residues [active] 511051002203 aspartate-rich region 2; other site 511051002204 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 511051002205 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 511051002206 TPP-binding site; other site 511051002207 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 511051002208 PYR/PP interface [polypeptide binding]; other site 511051002209 dimer interface [polypeptide binding]; other site 511051002210 TPP binding site [chemical binding]; other site 511051002211 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511051002212 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 511051002213 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511051002214 RNA binding surface [nucleotide binding]; other site 511051002215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051002216 S-adenosylmethionine binding site [chemical binding]; other site 511051002217 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 511051002218 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 511051002219 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 511051002220 Walker A/P-loop; other site 511051002221 ATP binding site [chemical binding]; other site 511051002222 Q-loop/lid; other site 511051002223 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 511051002224 ABC transporter signature motif; other site 511051002225 Walker B; other site 511051002226 D-loop; other site 511051002227 H-loop/switch region; other site 511051002228 butyrate kinase; Provisional; Region: PRK03011 511051002229 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 511051002230 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 511051002231 RNA binding site [nucleotide binding]; other site 511051002232 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 511051002233 RNA binding site [nucleotide binding]; other site 511051002234 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 511051002235 RNA binding site [nucleotide binding]; other site 511051002236 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 511051002237 RNA binding site [nucleotide binding]; other site 511051002238 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511051002239 acyl carrier protein; Provisional; Region: acpP; PRK00982 511051002240 prolyl-tRNA synthetase; Provisional; Region: PRK09194 511051002241 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 511051002242 dimer interface [polypeptide binding]; other site 511051002243 motif 1; other site 511051002244 active site 511051002245 motif 2; other site 511051002246 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 511051002247 putative deacylase active site [active] 511051002248 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511051002249 active site 511051002250 motif 3; other site 511051002251 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 511051002252 anticodon binding site; other site 511051002253 Competence-damaged protein; Region: CinA; pfam02464 511051002254 6-phosphofructokinase; Provisional; Region: PRK03202 511051002255 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 511051002256 active site 511051002257 ADP/pyrophosphate binding site [chemical binding]; other site 511051002258 dimerization interface [polypeptide binding]; other site 511051002259 allosteric effector site; other site 511051002260 fructose-1,6-bisphosphate binding site; other site 511051002261 6-phosphofructokinase; Provisional; Region: PRK03202 511051002262 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 511051002263 active site 511051002264 ADP/pyrophosphate binding site [chemical binding]; other site 511051002265 dimerization interface [polypeptide binding]; other site 511051002266 allosteric effector site; other site 511051002267 fructose-1,6-bisphosphate binding site; other site 511051002268 HAMP domain; Region: HAMP; pfam00672 511051002269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051002270 dimer interface [polypeptide binding]; other site 511051002271 phosphorylation site [posttranslational modification] 511051002272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051002273 ATP binding site [chemical binding]; other site 511051002274 Mg2+ binding site [ion binding]; other site 511051002275 G-X-G motif; other site 511051002276 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 511051002277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051002278 active site 511051002279 phosphorylation site [posttranslational modification] 511051002280 intermolecular recognition site; other site 511051002281 dimerization interface [polypeptide binding]; other site 511051002282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002283 Walker A motif; other site 511051002284 ATP binding site [chemical binding]; other site 511051002285 Walker B motif; other site 511051002286 arginine finger; other site 511051002287 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 511051002288 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 511051002289 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 511051002290 metal binding site [ion binding]; metal-binding site 511051002291 dimer interface [polypeptide binding]; other site 511051002292 KWG Leptospira; Region: KWG; pfam07656 511051002293 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 511051002294 rRNA interaction site [nucleotide binding]; other site 511051002295 S8 interaction site; other site 511051002296 putative laminin-1 binding site; other site 511051002297 elongation factor Ts; Reviewed; Region: tsf; PRK12332 511051002298 UBA/TS-N domain; Region: UBA; pfam00627 511051002299 Elongation factor TS; Region: EF_TS; pfam00889 511051002300 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 511051002301 nucleotide binding site [chemical binding]; other site 511051002302 substrate binding site [chemical binding]; other site 511051002303 ribosome recycling factor; Reviewed; Region: frr; PRK00083 511051002304 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 511051002305 hinge region; other site 511051002306 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 511051002307 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 511051002308 catalytic residue [active] 511051002309 putative FPP diphosphate binding site; other site 511051002310 putative FPP binding hydrophobic cleft; other site 511051002311 dimer interface [polypeptide binding]; other site 511051002312 putative IPP diphosphate binding site; other site 511051002313 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 511051002314 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 511051002315 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 511051002316 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 511051002317 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 511051002318 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 511051002319 active site 511051002320 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 511051002321 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511051002322 putative substrate binding region [chemical binding]; other site 511051002323 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 511051002324 GcpE protein; Region: GcpE; pfam04551 511051002325 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 511051002326 NurA nuclease; Region: NurA; smart00933 511051002327 Protein of unknown function (DUF401); Region: DUF401; cl00830 511051002328 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 511051002329 active site 511051002330 putative GTP cyclohydrolase; Provisional; Region: PRK13674 511051002331 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 511051002332 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 511051002333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051002334 ATP binding site [chemical binding]; other site 511051002335 putative Mg++ binding site [ion binding]; other site 511051002336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051002337 nucleotide binding region [chemical binding]; other site 511051002338 ATP-binding site [chemical binding]; other site 511051002339 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 511051002340 triosephosphate isomerase; Provisional; Region: PRK14567 511051002341 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 511051002342 substrate binding site [chemical binding]; other site 511051002343 dimer interface [polypeptide binding]; other site 511051002344 catalytic triad [active] 511051002345 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 511051002346 active site 511051002347 catalytic motif [active] 511051002348 Zn binding site [ion binding]; other site 511051002349 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 511051002350 Domain of unknown function DUF21; Region: DUF21; pfam01595 511051002351 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511051002352 Transporter associated domain; Region: CorC_HlyC; smart01091 511051002353 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 511051002354 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 511051002355 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051002356 Zn2+ binding site [ion binding]; other site 511051002357 Mg2+ binding site [ion binding]; other site 511051002358 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 511051002359 PhoH-like protein; Region: PhoH; pfam02562 511051002360 antiporter inner membrane protein; Provisional; Region: PRK11670 511051002361 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 511051002362 Walker A motif; other site 511051002363 Rrf2 family protein; Region: rrf2_super; TIGR00738 511051002364 Transcriptional regulator; Region: Rrf2; pfam02082 511051002365 Methyltransferase domain; Region: Methyltransf_23; pfam13489 511051002366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051002367 S-adenosylmethionine binding site [chemical binding]; other site 511051002368 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 511051002369 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 511051002370 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 511051002371 peptidase T; Region: peptidase-T; TIGR01882 511051002372 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 511051002373 metal binding site [ion binding]; metal-binding site 511051002374 dimer interface [polypeptide binding]; other site 511051002375 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 511051002376 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 511051002377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051002378 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 511051002379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051002380 DNA binding residues [nucleotide binding] 511051002381 DNA primase; Validated; Region: dnaG; PRK05667 511051002382 CHC2 zinc finger; Region: zf-CHC2; pfam01807 511051002383 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 511051002384 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 511051002385 active site 511051002386 metal binding site [ion binding]; metal-binding site 511051002387 interdomain interaction site; other site 511051002388 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 511051002389 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051002390 Zn2+ binding site [ion binding]; other site 511051002391 Mg2+ binding site [ion binding]; other site 511051002392 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 511051002393 pyruvate phosphate dikinase; Provisional; Region: PRK09279 511051002394 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 511051002395 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511051002396 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511051002397 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 511051002398 DALR anticodon binding domain; Region: DALR_1; pfam05746 511051002399 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 511051002400 motif 1; other site 511051002401 dimer interface [polypeptide binding]; other site 511051002402 active site 511051002403 motif 2; other site 511051002404 motif 3; other site 511051002405 Recombination protein O N terminal; Region: RecO_N; pfam11967 511051002406 DNA repair protein RecO; Region: reco; TIGR00613 511051002407 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 511051002408 intersubunit interface [polypeptide binding]; other site 511051002409 active site 511051002410 catalytic residue [active] 511051002411 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 511051002412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002413 Walker A motif; other site 511051002414 ATP binding site [chemical binding]; other site 511051002415 Walker B motif; other site 511051002416 arginine finger; other site 511051002417 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 511051002418 hypothetical protein; Validated; Region: PRK00153 511051002419 recombination protein RecR; Reviewed; Region: recR; PRK00076 511051002420 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 511051002421 RecR protein; Region: RecR; pfam02132 511051002422 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 511051002423 putative active site [active] 511051002424 putative metal-binding site [ion binding]; other site 511051002425 tetramer interface [polypeptide binding]; other site 511051002426 enolase; Provisional; Region: eno; PRK00077 511051002427 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 511051002428 dimer interface [polypeptide binding]; other site 511051002429 metal binding site [ion binding]; metal-binding site 511051002430 substrate binding pocket [chemical binding]; other site 511051002431 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 511051002432 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 511051002433 DNA binding site [nucleotide binding] 511051002434 catalytic residue [active] 511051002435 H2TH interface [polypeptide binding]; other site 511051002436 putative catalytic residues [active] 511051002437 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 511051002438 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511051002439 SLBB domain; Region: SLBB; pfam10531 511051002440 comEA protein; Region: comE; TIGR01259 511051002441 Helix-hairpin-helix motif; Region: HHH; pfam00633 511051002442 Competence protein; Region: Competence; pfam03772 511051002443 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 511051002444 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 511051002445 trimerization site [polypeptide binding]; other site 511051002446 active site 511051002447 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 511051002448 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 511051002449 active site 511051002450 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 511051002451 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051002452 active site 511051002453 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 511051002454 KaiC; Region: KaiC; pfam06745 511051002455 ATP binding site [chemical binding]; other site 511051002456 Walker A motif; other site 511051002457 Walker B motif; other site 511051002458 Predicted transcriptional regulators [Transcription]; Region: COG1318 511051002459 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 511051002460 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 511051002461 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 511051002462 dimer interface [polypeptide binding]; other site 511051002463 putative functional site; other site 511051002464 putative MPT binding site; other site 511051002465 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 511051002466 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 511051002467 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 511051002468 Ligand Binding Site [chemical binding]; other site 511051002469 Electron transfer flavoprotein domain; Region: ETF; pfam01012 511051002470 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 511051002471 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 511051002472 putative active site [active] 511051002473 substrate binding site [chemical binding]; other site 511051002474 putative cosubstrate binding site; other site 511051002475 catalytic site [active] 511051002476 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 511051002477 substrate binding site [chemical binding]; other site 511051002478 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 511051002479 active site 511051002480 catalytic residues [active] 511051002481 metal binding site [ion binding]; metal-binding site 511051002482 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 511051002483 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 511051002484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051002485 S-adenosylmethionine binding site [chemical binding]; other site 511051002486 peptide chain release factor 1; Validated; Region: prfA; PRK00591 511051002487 This domain is found in peptide chain release factors; Region: PCRF; smart00937 511051002488 RF-1 domain; Region: RF-1; pfam00472 511051002489 thymidine kinase; Provisional; Region: PRK04296 511051002490 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 511051002491 transcription termination factor Rho; Provisional; Region: PRK12608 511051002492 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 511051002493 RNA binding site [nucleotide binding]; other site 511051002494 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 511051002495 Walker A motif; other site 511051002496 ATP binding site [chemical binding]; other site 511051002497 Walker B motif; other site 511051002498 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 511051002499 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 511051002500 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 511051002501 Ligand Binding Site [chemical binding]; other site 511051002502 TilS substrate C-terminal domain; Region: TilS_C; smart00977 511051002503 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051002504 active site 511051002505 FtsH Extracellular; Region: FtsH_ext; pfam06480 511051002506 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 511051002507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051002508 Walker A motif; other site 511051002509 ATP binding site [chemical binding]; other site 511051002510 Walker B motif; other site 511051002511 arginine finger; other site 511051002512 Peptidase family M41; Region: Peptidase_M41; pfam01434 511051002513 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 511051002514 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511051002515 minor groove reading motif; other site 511051002516 helix-hairpin-helix signature motif; other site 511051002517 substrate binding pocket [chemical binding]; other site 511051002518 active site 511051002519 ferredoxin; Validated; Region: PRK07118 511051002520 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 511051002521 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 511051002522 transmembrane helices; other site 511051002523 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511051002524 Ligand Binding Site [chemical binding]; other site 511051002525 GTPase Era; Reviewed; Region: era; PRK00089 511051002526 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 511051002527 G1 box; other site 511051002528 GTP/Mg2+ binding site [chemical binding]; other site 511051002529 Switch I region; other site 511051002530 G2 box; other site 511051002531 Switch II region; other site 511051002532 G3 box; other site 511051002533 G4 box; other site 511051002534 G5 box; other site 511051002535 KH domain; Region: KH_2; pfam07650 511051002536 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 511051002537 homotrimer interaction site [polypeptide binding]; other site 511051002538 putative active site [active] 511051002539 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511051002540 Ligand Binding Site [chemical binding]; other site 511051002541 Bacitracin resistance protein BacA; Region: BacA; pfam02673 511051002542 intracellular protease, PfpI family; Region: PfpI; TIGR01382 511051002543 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 511051002544 proposed catalytic triad [active] 511051002545 conserved cys residue [active] 511051002546 Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907 511051002547 ADP-ribose binding site [chemical binding]; other site 511051002548 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 511051002549 RNA/DNA hybrid binding site [nucleotide binding]; other site 511051002550 active site 511051002551 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 511051002552 NHL repeat; Region: NHL; pfam01436 511051002553 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 511051002554 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 511051002555 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051002556 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051002557 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 511051002558 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 511051002559 putative active site [active] 511051002560 catalytic triad [active] 511051002561 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 511051002562 putative integrin binding motif; other site 511051002563 PA/protease domain interface [polypeptide binding]; other site 511051002564 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 511051002565 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 511051002566 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 511051002567 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 511051002568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511051002569 motif II; other site 511051002570 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 511051002571 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 511051002572 active site 511051002573 NAD binding site [chemical binding]; other site 511051002574 metal binding site [ion binding]; metal-binding site 511051002575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 511051002576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051002577 Uncharacterized conserved protein [Function unknown]; Region: COG1633 511051002578 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 511051002579 diiron binding motif [ion binding]; other site 511051002580 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051002581 Uncharacterized conserved protein [Function unknown]; Region: COG1633 511051002582 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 511051002583 diiron binding motif [ion binding]; other site 511051002584 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 511051002585 Rubredoxin; Region: Rubredoxin; pfam00301 511051002586 iron binding site [ion binding]; other site 511051002587 Rubrerythrin [Energy production and conversion]; Region: COG1592 511051002588 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 511051002589 binuclear metal center [ion binding]; other site 511051002590 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 511051002591 iron binding site [ion binding]; other site 511051002592 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 511051002593 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 511051002594 ATP binding site [chemical binding]; other site 511051002595 substrate interface [chemical binding]; other site 511051002596 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 511051002597 Ubiquitin-like proteins; Region: UBQ; cl00155 511051002598 charged pocket; other site 511051002599 hydrophobic patch; other site 511051002600 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 511051002601 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 511051002602 trimerization site [polypeptide binding]; other site 511051002603 active site 511051002604 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 511051002605 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 511051002606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511051002607 catalytic residue [active] 511051002608 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 511051002609 Uncharacterized conserved protein [Function unknown]; Region: COG2461 511051002610 Family of unknown function (DUF438); Region: DUF438; pfam04282 511051002611 Hemerythrin-like domain; Region: Hr-like; cd12108 511051002612 Fe binding site [ion binding]; other site 511051002613 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 511051002614 threonine synthase; Validated; Region: PRK06260 511051002615 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 511051002616 homodimer interface [polypeptide binding]; other site 511051002617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051002618 catalytic residue [active] 511051002619 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 511051002620 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 511051002621 putative ligand binding site [chemical binding]; other site 511051002622 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 511051002623 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511051002624 Walker A/P-loop; other site 511051002625 ATP binding site [chemical binding]; other site 511051002626 Q-loop/lid; other site 511051002627 ABC transporter signature motif; other site 511051002628 Walker B; other site 511051002629 D-loop; other site 511051002630 H-loop/switch region; other site 511051002631 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511051002632 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511051002633 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051002634 TM-ABC transporter signature motif; other site 511051002635 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511051002636 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051002637 TM-ABC transporter signature motif; other site 511051002638 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051002639 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 511051002640 active site 511051002641 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 511051002642 Amidohydrolase; Region: Amidohydro_5; pfam13594 511051002643 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 511051002644 active site 511051002645 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 511051002646 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 511051002647 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051002648 active site 511051002649 Protein of unknown function (DUF503); Region: DUF503; pfam04456 511051002650 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 511051002651 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 511051002652 Walker A/P-loop; other site 511051002653 ATP binding site [chemical binding]; other site 511051002654 Q-loop/lid; other site 511051002655 ABC transporter signature motif; other site 511051002656 Walker B; other site 511051002657 D-loop; other site 511051002658 H-loop/switch region; other site 511051002659 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 511051002660 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 511051002661 ADP-glucose phosphorylase; Region: PLN02643 511051002662 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 511051002663 dimer interface [polypeptide binding]; other site 511051002664 active site 511051002665 glycogen synthase; Provisional; Region: glgA; PRK00654 511051002666 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 511051002667 ADP-binding pocket [chemical binding]; other site 511051002668 homodimer interface [polypeptide binding]; other site 511051002669 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 511051002670 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 511051002671 active site 511051002672 substrate binding site [chemical binding]; other site 511051002673 metal binding site [ion binding]; metal-binding site 511051002674 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 511051002675 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 511051002676 active site 511051002677 dimer interface [polypeptide binding]; other site 511051002678 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 511051002679 dimer interface [polypeptide binding]; other site 511051002680 active site 511051002681 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 511051002682 C-terminal peptidase (prc); Region: prc; TIGR00225 511051002683 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 511051002684 protein binding site [polypeptide binding]; other site 511051002685 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 511051002686 Catalytic dyad [active] 511051002687 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 511051002688 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 511051002689 catalytic site [active] 511051002690 G-X2-G-X-G-K; other site 511051002691 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 511051002692 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 511051002693 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 511051002694 CoA-binding site [chemical binding]; other site 511051002695 ATP-binding [chemical binding]; other site 511051002696 DNA polymerase I; Provisional; Region: PRK05755 511051002697 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 511051002698 active site 511051002699 metal binding site 1 [ion binding]; metal-binding site 511051002700 putative 5' ssDNA interaction site; other site 511051002701 metal binding site 3; metal-binding site 511051002702 metal binding site 2 [ion binding]; metal-binding site 511051002703 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 511051002704 putative DNA binding site [nucleotide binding]; other site 511051002705 putative metal binding site [ion binding]; other site 511051002706 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 511051002707 active site 511051002708 substrate binding site [chemical binding]; other site 511051002709 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 511051002710 active site 511051002711 DNA binding site [nucleotide binding] 511051002712 catalytic site [active] 511051002713 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 511051002714 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 511051002715 active site 511051002716 NAD binding site [chemical binding]; other site 511051002717 metal binding site [ion binding]; metal-binding site 511051002718 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 511051002719 Sporulation and spore germination; Region: Germane; pfam10646 511051002720 Domain of unknown function DUF59; Region: DUF59; pfam01883 511051002721 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 511051002722 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 511051002723 inhibitor site; inhibition site 511051002724 active site 511051002725 dimer interface [polypeptide binding]; other site 511051002726 catalytic residue [active] 511051002727 Protein of unknown function DUF89; Region: DUF89; cl15397 511051002728 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 511051002729 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 511051002730 peptide binding site [polypeptide binding]; other site 511051002731 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511051002732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051002733 dimer interface [polypeptide binding]; other site 511051002734 conserved gate region; other site 511051002735 putative PBP binding loops; other site 511051002736 ABC-ATPase subunit interface; other site 511051002737 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 511051002738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051002739 dimer interface [polypeptide binding]; other site 511051002740 conserved gate region; other site 511051002741 putative PBP binding loops; other site 511051002742 ABC-ATPase subunit interface; other site 511051002743 QueT transporter; Region: QueT; pfam06177 511051002744 Predicted amidohydrolase [General function prediction only]; Region: COG0388 511051002745 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 511051002746 active site 511051002747 catalytic triad [active] 511051002748 dimer interface [polypeptide binding]; other site 511051002749 NAD synthetase; Provisional; Region: PRK13980 511051002750 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 511051002751 homodimer interface [polypeptide binding]; other site 511051002752 NAD binding pocket [chemical binding]; other site 511051002753 ATP binding pocket [chemical binding]; other site 511051002754 Mg binding site [ion binding]; other site 511051002755 active-site loop [active] 511051002756 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 511051002757 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 511051002758 active site 511051002759 metal binding site [ion binding]; metal-binding site 511051002760 homotetramer interface [polypeptide binding]; other site 511051002761 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 511051002762 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 511051002763 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 511051002764 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511051002765 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511051002766 oligomer interface [polypeptide binding]; other site 511051002767 active site 511051002768 metal binding site [ion binding]; metal-binding site 511051002769 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511051002770 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511051002771 oligomer interface [polypeptide binding]; other site 511051002772 active site 511051002773 metal binding site [ion binding]; metal-binding site 511051002774 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511051002775 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 511051002776 oligomer interface [polypeptide binding]; other site 511051002777 active site 511051002778 metal binding site [ion binding]; metal-binding site 511051002779 Nucleoside diphosphate kinase; Region: NDK; pfam00334 511051002780 active site 511051002781 multimer interface [polypeptide binding]; other site 511051002782 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 511051002783 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 511051002784 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 511051002785 Walker A/P-loop; other site 511051002786 ATP binding site [chemical binding]; other site 511051002787 Q-loop/lid; other site 511051002788 ABC transporter signature motif; other site 511051002789 Walker B; other site 511051002790 D-loop; other site 511051002791 H-loop/switch region; other site 511051002792 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 511051002793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 511051002794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051002795 dimer interface [polypeptide binding]; other site 511051002796 conserved gate region; other site 511051002797 putative PBP binding loops; other site 511051002798 ABC-ATPase subunit interface; other site 511051002799 TIGR04076 family protein; Region: TIGR04076 511051002800 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar1_1; cd09127 511051002801 PLD-like domain; Region: PLDc_2; pfam13091 511051002802 putative active site [active] 511051002803 putative catalytic site [active] 511051002804 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051002805 PLD-like domain; Region: PLDc_2; pfam13091 511051002806 putative active site [active] 511051002807 catalytic site [active] 511051002808 4-alpha-glucanotransferase; Provisional; Region: PRK14508 511051002809 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 511051002810 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 511051002811 B12 binding site [chemical binding]; other site 511051002812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051002813 FeS/SAM binding site; other site 511051002814 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 511051002815 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 511051002816 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 511051002817 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 511051002818 Switch I; other site 511051002819 Switch II; other site 511051002820 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 511051002821 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 511051002822 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 511051002823 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511051002824 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511051002825 rod shape-determining protein MreC; Provisional; Region: PRK13922 511051002826 rod shape-determining protein MreC; Region: MreC; pfam04085 511051002827 rod shape-determining protein MreB; Provisional; Region: PRK13927 511051002828 MreB and similar proteins; Region: MreB_like; cd10225 511051002829 nucleotide binding site [chemical binding]; other site 511051002830 Mg binding site [ion binding]; other site 511051002831 putative protofilament interaction site [polypeptide binding]; other site 511051002832 RodZ interaction site [polypeptide binding]; other site 511051002833 Maf-like protein; Region: Maf; pfam02545 511051002834 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 511051002835 active site 511051002836 dimer interface [polypeptide binding]; other site 511051002837 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 511051002838 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 511051002839 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846 511051002840 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 511051002841 ApbE family; Region: ApbE; pfam02424 511051002842 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 511051002843 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 511051002844 putative oxidoreductase; Provisional; Region: PRK12831 511051002845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 511051002846 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 511051002847 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 511051002848 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 511051002849 FAD binding pocket [chemical binding]; other site 511051002850 FAD binding motif [chemical binding]; other site 511051002851 phosphate binding motif [ion binding]; other site 511051002852 beta-alpha-beta structure motif; other site 511051002853 NAD binding pocket [chemical binding]; other site 511051002854 Iron coordination center [ion binding]; other site 511051002855 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 511051002856 active site 511051002857 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 511051002858 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 511051002859 active site 511051002860 HIGH motif; other site 511051002861 KMSKS motif; other site 511051002862 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 511051002863 tRNA binding surface [nucleotide binding]; other site 511051002864 anticodon binding site; other site 511051002865 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 511051002866 dimer interface [polypeptide binding]; other site 511051002867 putative tRNA-binding site [nucleotide binding]; other site 511051002868 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 511051002869 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 511051002870 Oligomerisation domain; Region: Oligomerisation; pfam02410 511051002871 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 511051002872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511051002873 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051002874 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 511051002875 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 511051002876 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 511051002877 catalytic residues [active] 511051002878 ornithine carbamoyltransferase; Provisional; Region: PRK00779 511051002879 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511051002880 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511051002881 Predicted GTPase [General function prediction only]; Region: COG2403 511051002882 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 511051002883 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 511051002884 active site 511051002885 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 511051002886 putative ligand binding pocket/active site [active] 511051002887 putative metal binding site [ion binding]; other site 511051002888 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 511051002889 AMMECR1; Region: AMMECR1; pfam01871 511051002890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051002891 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051002892 putative substrate translocation pore; other site 511051002893 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511051002894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511051002895 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 511051002896 Walker A/P-loop; other site 511051002897 ATP binding site [chemical binding]; other site 511051002898 Q-loop/lid; other site 511051002899 ABC transporter signature motif; other site 511051002900 Walker B; other site 511051002901 D-loop; other site 511051002902 H-loop/switch region; other site 511051002903 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511051002904 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511051002905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051002906 Walker A/P-loop; other site 511051002907 ATP binding site [chemical binding]; other site 511051002908 Q-loop/lid; other site 511051002909 ABC transporter signature motif; other site 511051002910 Walker B; other site 511051002911 D-loop; other site 511051002912 H-loop/switch region; other site 511051002913 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 511051002914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 511051002915 hypothetical protein; Provisional; Region: PRK07236 511051002916 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511051002917 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 511051002918 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 511051002919 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 511051002920 Asp23 family; Region: Asp23; pfam03780 511051002921 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 511051002922 DAK2 domain; Region: Dak2; pfam02734 511051002923 purine nucleoside phosphorylase; Provisional; Region: PRK08202 511051002924 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511051002925 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 511051002926 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511051002927 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 511051002928 DHH family; Region: DHH; pfam01368 511051002929 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 511051002930 FOG: CBS domain [General function prediction only]; Region: COG0517 511051002931 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 511051002932 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 511051002933 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 511051002934 active site 511051002935 NTP binding site [chemical binding]; other site 511051002936 metal binding triad [ion binding]; metal-binding site 511051002937 MoxR-like ATPases [General function prediction only]; Region: COG0714 511051002938 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 511051002939 ATP binding site [chemical binding]; other site 511051002940 Walker A motif; other site 511051002941 Walker B motif; other site 511051002942 arginine finger; other site 511051002943 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 511051002944 Protein of unknown function DUF58; Region: DUF58; pfam01882 511051002945 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 511051002946 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 511051002947 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 511051002948 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 511051002949 catalytic residues [active] 511051002950 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511051002951 catalytic residues [active] 511051002952 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 511051002953 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 511051002954 substrate binding site [chemical binding]; other site 511051002955 hexamer interface [polypeptide binding]; other site 511051002956 metal binding site [ion binding]; metal-binding site 511051002957 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511051002958 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511051002959 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511051002960 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 511051002961 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 511051002962 active site 511051002963 (T/H)XGH motif; other site 511051002964 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 511051002965 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 511051002966 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 511051002967 putative dimer interface [polypeptide binding]; other site 511051002968 putative anticodon binding site; other site 511051002969 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 511051002970 homodimer interface [polypeptide binding]; other site 511051002971 motif 1; other site 511051002972 motif 2; other site 511051002973 active site 511051002974 motif 3; other site 511051002975 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 511051002976 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 511051002977 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 511051002978 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 511051002979 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 511051002980 active site 511051002981 Zn binding site [ion binding]; other site 511051002982 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511051002983 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511051002984 nucleotide binding site [chemical binding]; other site 511051002985 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 511051002986 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511051002987 active site 511051002988 DNA binding site [nucleotide binding] 511051002989 Int/Topo IB signature motif; other site 511051002990 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 511051002991 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 511051002992 active site 511051002993 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 511051002994 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511051002995 active site 511051002996 catalytic site [active] 511051002997 substrate binding site [chemical binding]; other site 511051002998 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 511051002999 MutS domain III; Region: MutS_III; pfam05192 511051003000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051003001 Walker A/P-loop; other site 511051003002 ATP binding site [chemical binding]; other site 511051003003 Q-loop/lid; other site 511051003004 ABC transporter signature motif; other site 511051003005 Walker B; other site 511051003006 D-loop; other site 511051003007 H-loop/switch region; other site 511051003008 Smr domain; Region: Smr; pfam01713 511051003009 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 511051003010 metal binding triad [ion binding]; metal-binding site 511051003011 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 511051003012 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 511051003013 active site 511051003014 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 511051003015 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511051003016 putative tRNA-binding site [nucleotide binding]; other site 511051003017 B3/4 domain; Region: B3_4; pfam03483 511051003018 tRNA synthetase B5 domain; Region: B5; smart00874 511051003019 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 511051003020 dimer interface [polypeptide binding]; other site 511051003021 motif 1; other site 511051003022 motif 3; other site 511051003023 motif 2; other site 511051003024 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 511051003025 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 511051003026 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 511051003027 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 511051003028 dimer interface [polypeptide binding]; other site 511051003029 motif 1; other site 511051003030 active site 511051003031 motif 2; other site 511051003032 motif 3; other site 511051003033 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 511051003034 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 511051003035 transmembrane helices; other site 511051003036 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 511051003037 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 511051003038 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 511051003039 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 511051003040 TPP-binding site [chemical binding]; other site 511051003041 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 511051003042 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051003043 dimer interface [polypeptide binding]; other site 511051003044 PYR/PP interface [polypeptide binding]; other site 511051003045 TPP binding site [chemical binding]; other site 511051003046 substrate binding site [chemical binding]; other site 511051003047 Ferredoxin [Energy production and conversion]; Region: COG1146 511051003048 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 511051003049 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 511051003050 CoA binding domain; Region: CoA_binding; smart00881 511051003051 CoA-ligase; Region: Ligase_CoA; pfam00549 511051003052 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 511051003053 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 511051003054 CoA-ligase; Region: Ligase_CoA; pfam00549 511051003055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 511051003056 YheO-like PAS domain; Region: PAS_6; pfam08348 511051003057 HTH domain; Region: HTH_22; pfam13309 511051003058 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 511051003059 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 511051003060 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 511051003061 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 511051003062 4Fe-4S binding domain; Region: Fer4; pfam00037 511051003063 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511051003064 catalytic loop [active] 511051003065 iron binding site [ion binding]; other site 511051003066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 511051003067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511051003068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051003069 Integrase core domain; Region: rve; pfam00665 511051003070 Putative amidase domain; Region: Amidase_6; pfam12671 511051003071 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 511051003072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 511051003073 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 511051003074 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 511051003075 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 511051003076 active site 511051003077 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 511051003078 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 511051003079 active site 511051003080 DNA binding site [nucleotide binding] 511051003081 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 511051003082 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511051003083 carboxyltransferase (CT) interaction site; other site 511051003084 biotinylation site [posttranslational modification]; other site 511051003085 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 511051003086 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 511051003087 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 511051003088 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 511051003089 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 511051003090 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 511051003091 MPT binding site; other site 511051003092 trimer interface [polypeptide binding]; other site 511051003093 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 511051003094 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 511051003095 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 511051003096 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511051003097 protein binding site [polypeptide binding]; other site 511051003098 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 511051003099 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 511051003100 iron binding site [ion binding]; other site 511051003101 S-adenosylmethionine synthetase; Validated; Region: PRK05250 511051003102 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 511051003103 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 511051003104 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 511051003105 Flavoprotein; Region: Flavoprotein; cl08021 511051003106 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 511051003107 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511051003108 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 511051003109 active site 511051003110 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 511051003111 Peptidase family M23; Region: Peptidase_M23; pfam01551 511051003112 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 511051003113 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 511051003114 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511051003115 Walker A/P-loop; other site 511051003116 ATP binding site [chemical binding]; other site 511051003117 Q-loop/lid; other site 511051003118 ABC transporter signature motif; other site 511051003119 Walker B; other site 511051003120 D-loop; other site 511051003121 H-loop/switch region; other site 511051003122 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511051003123 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511051003124 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 511051003125 peptide chain release factor 2; Validated; Region: prfB; PRK00578 511051003126 PCRF domain; Region: PCRF; pfam03462 511051003127 RF-1 domain; Region: RF-1; pfam00472 511051003128 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 511051003129 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 511051003130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051003131 nucleotide binding region [chemical binding]; other site 511051003132 ATP-binding site [chemical binding]; other site 511051003133 Sigma 54 modulation protein / S30EA ribosomal protein; Region: Ribosomal_S30AE; pfam02482 511051003134 30S subunit binding site; other site 511051003135 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 511051003136 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 511051003137 active site 511051003138 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511051003139 dimer interface [polypeptide binding]; other site 511051003140 substrate binding site [chemical binding]; other site 511051003141 catalytic residues [active] 511051003142 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 511051003143 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 511051003144 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 511051003145 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 511051003146 active site 511051003147 Competence protein A; Region: Competence_A; pfam11104 511051003148 Cell division protein FtsA; Region: FtsA; cl17206 511051003149 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 511051003150 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 511051003151 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 511051003152 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 511051003153 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 511051003154 Ribosome-binding factor A; Region: RBFA; pfam02033 511051003155 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 511051003156 DHH family; Region: DHH; pfam01368 511051003157 DHHA1 domain; Region: DHHA1; pfam02272 511051003158 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 511051003159 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 511051003160 tandem repeat interface [polypeptide binding]; other site 511051003161 oligomer interface [polypeptide binding]; other site 511051003162 active site residues [active] 511051003163 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 511051003164 Part of AAA domain; Region: AAA_19; pfam13245 511051003165 Family description; Region: UvrD_C_2; pfam13538 511051003166 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 511051003167 active site 2 [active] 511051003168 Transglycosylase; Region: Transgly; pfam00912 511051003169 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 511051003170 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 511051003171 seryl-tRNA synthetase; Provisional; Region: PRK05431 511051003172 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 511051003173 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 511051003174 dimer interface [polypeptide binding]; other site 511051003175 active site 511051003176 motif 1; other site 511051003177 motif 2; other site 511051003178 motif 3; other site 511051003179 Uncharacterized conserved protein [Function unknown]; Region: COG3379 511051003180 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 511051003181 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 511051003182 EamA-like transporter family; Region: EamA; pfam00892 511051003183 EamA-like transporter family; Region: EamA; pfam00892 511051003184 Protein of unknown function DUF72; Region: DUF72; pfam01904 511051003185 fructuronate transporter; Provisional; Region: PRK10034; cl15264 511051003186 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 511051003187 fructuronate transporter; Provisional; Region: PRK10034; cl15264 511051003188 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 511051003189 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 511051003190 MOFRL family; Region: MOFRL; pfam05161 511051003191 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 511051003192 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 511051003193 active site 511051003194 multimer interface [polypeptide binding]; other site 511051003195 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 511051003196 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 511051003197 predicted active site [active] 511051003198 catalytic triad [active] 511051003199 hypothetical protein; Validated; Region: PRK00110 511051003200 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 511051003201 active site 511051003202 putative DNA-binding cleft [nucleotide binding]; other site 511051003203 dimer interface [polypeptide binding]; other site 511051003204 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 511051003205 RuvA N terminal domain; Region: RuvA_N; pfam01330 511051003206 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 511051003207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051003208 Walker A motif; other site 511051003209 ATP binding site [chemical binding]; other site 511051003210 Walker B motif; other site 511051003211 arginine finger; other site 511051003212 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 511051003213 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 511051003214 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 511051003215 ligand binding site; other site 511051003216 oligomer interface; other site 511051003217 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 511051003218 dimer interface [polypeptide binding]; other site 511051003219 N-terminal domain interface [polypeptide binding]; other site 511051003220 sulfate 1 binding site; other site 511051003221 Uncharacterized conserved protein [Function unknown]; Region: COG1543 511051003222 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 511051003223 active site 511051003224 substrate binding site [chemical binding]; other site 511051003225 catalytic site [active] 511051003226 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 511051003227 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 511051003228 Uncharacterized conserved protein [Function unknown]; Region: COG0327 511051003229 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 511051003230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 511051003231 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 511051003232 Uncharacterized conserved protein [Function unknown]; Region: COG0327 511051003233 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 511051003234 core dimer interface [polypeptide binding]; other site 511051003235 peripheral dimer interface [polypeptide binding]; other site 511051003236 L10 interface [polypeptide binding]; other site 511051003237 L11 interface [polypeptide binding]; other site 511051003238 putative EF-Tu interaction site [polypeptide binding]; other site 511051003239 putative EF-G interaction site [polypeptide binding]; other site 511051003240 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 511051003241 23S rRNA interface [nucleotide binding]; other site 511051003242 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 511051003243 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 511051003244 mRNA/rRNA interface [nucleotide binding]; other site 511051003245 Ribosomal protein L11/L12; Region: RL11; smart00649 511051003246 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 511051003247 putative thiostrepton binding site; other site 511051003248 23S rRNA interface [nucleotide binding]; other site 511051003249 L7/L12 interface [polypeptide binding]; other site 511051003250 L25 interface [polypeptide binding]; other site 511051003251 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 511051003252 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 511051003253 putative homodimer interface [polypeptide binding]; other site 511051003254 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 511051003255 heterodimer interface [polypeptide binding]; other site 511051003256 homodimer interface [polypeptide binding]; other site 511051003257 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 511051003258 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 511051003259 elongation factor Tu; Reviewed; Region: PRK00049 511051003260 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511051003261 G1 box; other site 511051003262 GEF interaction site [polypeptide binding]; other site 511051003263 GTP/Mg2+ binding site [chemical binding]; other site 511051003264 Switch I region; other site 511051003265 G2 box; other site 511051003266 G3 box; other site 511051003267 Switch II region; other site 511051003268 G4 box; other site 511051003269 G5 box; other site 511051003270 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511051003271 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511051003272 Antibiotic Binding Site [chemical binding]; other site 511051003273 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 511051003274 RNA polymerase factor sigma-70; Validated; Region: PRK08295 511051003275 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 511051003276 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 511051003277 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 511051003278 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511051003279 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 511051003280 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511051003281 active site 511051003282 HIGH motif; other site 511051003283 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511051003284 KMSKS motif; other site 511051003285 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511051003286 tRNA binding surface [nucleotide binding]; other site 511051003287 anticodon binding site; other site 511051003288 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511051003289 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511051003290 active site 511051003291 HIGH motif; other site 511051003292 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511051003293 active site 511051003294 KMSKS motif; other site 511051003295 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 511051003296 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 511051003297 23S rRNA interface [nucleotide binding]; other site 511051003298 L3 interface [polypeptide binding]; other site 511051003299 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 511051003300 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 511051003301 active site 511051003302 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 511051003303 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511051003304 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511051003305 Walker A/P-loop; other site 511051003306 ATP binding site [chemical binding]; other site 511051003307 Q-loop/lid; other site 511051003308 ABC transporter signature motif; other site 511051003309 Walker B; other site 511051003310 D-loop; other site 511051003311 H-loop/switch region; other site 511051003312 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 511051003313 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511051003314 Walker A/P-loop; other site 511051003315 ATP binding site [chemical binding]; other site 511051003316 Q-loop/lid; other site 511051003317 ABC transporter signature motif; other site 511051003318 Walker B; other site 511051003319 D-loop; other site 511051003320 H-loop/switch region; other site 511051003321 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 511051003322 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 511051003323 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 511051003324 alphaNTD - beta interaction site [polypeptide binding]; other site 511051003325 alphaNTD homodimer interface [polypeptide binding]; other site 511051003326 alphaNTD - beta' interaction site [polypeptide binding]; other site 511051003327 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 511051003328 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 511051003329 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 511051003330 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511051003331 RNA binding surface [nucleotide binding]; other site 511051003332 30S ribosomal protein S11; Validated; Region: PRK05309 511051003333 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 511051003334 30S ribosomal protein S13; Region: bact_S13; TIGR03631 511051003335 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 511051003336 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 511051003337 rRNA binding site [nucleotide binding]; other site 511051003338 predicted 30S ribosome binding site; other site 511051003339 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 511051003340 active site 511051003341 adenylate kinase; Reviewed; Region: adk; PRK00279 511051003342 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 511051003343 AMP-binding site [chemical binding]; other site 511051003344 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 511051003345 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 511051003346 SecY translocase; Region: SecY; pfam00344 511051003347 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 511051003348 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 511051003349 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 511051003350 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 511051003351 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 511051003352 23S rRNA interface [nucleotide binding]; other site 511051003353 5S rRNA interface [nucleotide binding]; other site 511051003354 L27 interface [polypeptide binding]; other site 511051003355 L5 interface [polypeptide binding]; other site 511051003356 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 511051003357 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511051003358 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511051003359 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 511051003360 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 511051003361 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 511051003362 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 511051003363 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 511051003364 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 511051003365 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 511051003366 RNA binding site [nucleotide binding]; other site 511051003367 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 511051003368 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 511051003369 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 511051003370 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 511051003371 23S rRNA interface [nucleotide binding]; other site 511051003372 putative translocon interaction site; other site 511051003373 signal recognition particle (SRP54) interaction site; other site 511051003374 L23 interface [polypeptide binding]; other site 511051003375 trigger factor interaction site; other site 511051003376 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 511051003377 23S rRNA interface [nucleotide binding]; other site 511051003378 5S rRNA interface [nucleotide binding]; other site 511051003379 putative antibiotic binding site [chemical binding]; other site 511051003380 L25 interface [polypeptide binding]; other site 511051003381 L27 interface [polypeptide binding]; other site 511051003382 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 511051003383 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 511051003384 G-X-X-G motif; other site 511051003385 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 511051003386 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 511051003387 putative translocon binding site; other site 511051003388 protein-rRNA interface [nucleotide binding]; other site 511051003389 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 511051003390 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 511051003391 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 511051003392 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 511051003393 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 511051003394 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 511051003395 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 511051003396 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 511051003397 elongation factor Tu; Reviewed; Region: PRK00049 511051003398 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511051003399 G1 box; other site 511051003400 GEF interaction site [polypeptide binding]; other site 511051003401 GTP/Mg2+ binding site [chemical binding]; other site 511051003402 Switch I region; other site 511051003403 G2 box; other site 511051003404 G3 box; other site 511051003405 Switch II region; other site 511051003406 G4 box; other site 511051003407 G5 box; other site 511051003408 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511051003409 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511051003410 Antibiotic Binding Site [chemical binding]; other site 511051003411 elongation factor G; Reviewed; Region: PRK00007 511051003412 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 511051003413 G1 box; other site 511051003414 putative GEF interaction site [polypeptide binding]; other site 511051003415 GTP/Mg2+ binding site [chemical binding]; other site 511051003416 Switch I region; other site 511051003417 G2 box; other site 511051003418 G3 box; other site 511051003419 Switch II region; other site 511051003420 G4 box; other site 511051003421 G5 box; other site 511051003422 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 511051003423 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 511051003424 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 511051003425 30S ribosomal protein S7; Validated; Region: PRK05302 511051003426 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 511051003427 S17 interaction site [polypeptide binding]; other site 511051003428 S8 interaction site; other site 511051003429 16S rRNA interaction site [nucleotide binding]; other site 511051003430 streptomycin interaction site [chemical binding]; other site 511051003431 23S rRNA interaction site [nucleotide binding]; other site 511051003432 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 511051003433 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 511051003434 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 511051003435 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 511051003436 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 511051003437 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 511051003438 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 511051003439 G-loop; other site 511051003440 DNA binding site [nucleotide binding] 511051003441 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 511051003442 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 511051003443 elongation factor G; Reviewed; Region: PRK12740 511051003444 G1 box; other site 511051003445 putative GEF interaction site [polypeptide binding]; other site 511051003446 GTP/Mg2+ binding site [chemical binding]; other site 511051003447 Switch I region; other site 511051003448 G2 box; other site 511051003449 G3 box; other site 511051003450 Switch II region; other site 511051003451 G4 box; other site 511051003452 G5 box; other site 511051003453 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 511051003454 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 511051003455 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 511051003456 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 511051003457 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 511051003458 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 511051003459 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 511051003460 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 511051003461 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 511051003462 RPB10 interaction site [polypeptide binding]; other site 511051003463 RPB1 interaction site [polypeptide binding]; other site 511051003464 RPB11 interaction site [polypeptide binding]; other site 511051003465 RPB3 interaction site [polypeptide binding]; other site 511051003466 RPB12 interaction site [polypeptide binding]; other site 511051003467 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 511051003468 trimer interface [polypeptide binding]; other site 511051003469 dimer interface [polypeptide binding]; other site 511051003470 putative active site [active] 511051003471 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 511051003472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051003473 FeS/SAM binding site; other site 511051003474 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 511051003475 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 511051003476 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 511051003477 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 511051003478 Ligand binding site; other site 511051003479 Putative Catalytic site; other site 511051003480 DXD motif; other site 511051003481 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 511051003482 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 511051003483 putative acyl-acceptor binding pocket; other site 511051003484 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 511051003485 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511051003486 dimer interface [polypeptide binding]; other site 511051003487 ADP-ribose binding site [chemical binding]; other site 511051003488 active site 511051003489 nudix motif; other site 511051003490 metal binding site [ion binding]; metal-binding site 511051003491 ATP synthase subunit D; Region: ATP-synt_D; cl00613 511051003492 V-type ATP synthase subunit B; Provisional; Region: PRK04196 511051003493 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511051003494 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 511051003495 Walker A motif homologous position; other site 511051003496 Walker B motif; other site 511051003497 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511051003498 V-type ATP synthase subunit A; Provisional; Region: PRK04192 511051003499 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511051003500 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 511051003501 Walker A motif/ATP binding site; other site 511051003502 Walker B motif; other site 511051003503 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511051003504 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 511051003505 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 511051003506 V-type ATP synthase subunit K; Validated; Region: PRK06558 511051003507 V-type ATP synthase subunit I; Validated; Region: PRK05771 511051003508 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 511051003509 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 511051003510 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 511051003511 homodimer interface [polypeptide binding]; other site 511051003512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051003513 catalytic residue [active] 511051003514 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 511051003515 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 511051003516 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 511051003517 Putative zinc ribbon domain; Region: DUF164; pfam02591 511051003518 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 511051003519 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511051003520 Walker A/P-loop; other site 511051003521 ATP binding site [chemical binding]; other site 511051003522 Q-loop/lid; other site 511051003523 ABC transporter signature motif; other site 511051003524 Walker B; other site 511051003525 D-loop; other site 511051003526 H-loop/switch region; other site 511051003527 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 511051003528 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 511051003529 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511051003530 Walker A/P-loop; other site 511051003531 ATP binding site [chemical binding]; other site 511051003532 Q-loop/lid; other site 511051003533 ABC transporter signature motif; other site 511051003534 Walker B; other site 511051003535 D-loop; other site 511051003536 H-loop/switch region; other site 511051003537 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 511051003538 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 511051003539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003540 dimer interface [polypeptide binding]; other site 511051003541 conserved gate region; other site 511051003542 putative PBP binding loops; other site 511051003543 ABC-ATPase subunit interface; other site 511051003544 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511051003545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003546 dimer interface [polypeptide binding]; other site 511051003547 conserved gate region; other site 511051003548 putative PBP binding loops; other site 511051003549 ABC-ATPase subunit interface; other site 511051003550 S-layer homology domain; Region: SLH; pfam00395 511051003551 S-layer homology domain; Region: SLH; pfam00395 511051003552 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 511051003553 peptide binding site [polypeptide binding]; other site 511051003554 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 511051003555 dimer interface [polypeptide binding]; other site 511051003556 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 511051003557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051003558 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051003559 DNA binding residues [nucleotide binding] 511051003560 HlyD family secretion protein; Region: HlyD_2; pfam12700 511051003561 cell division protein FtsZ; Validated; Region: PRK09330 511051003562 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 511051003563 nucleotide binding site [chemical binding]; other site 511051003564 SulA interaction site; other site 511051003565 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 511051003566 Cell division protein FtsA; Region: FtsA; smart00842 511051003567 Cell division protein FtsA; Region: FtsA; pfam14450 511051003568 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 511051003569 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 511051003570 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511051003571 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 511051003572 FAD binding domain; Region: FAD_binding_4; pfam01565 511051003573 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 511051003574 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 511051003575 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003576 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003577 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 511051003578 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 511051003579 active site 511051003580 homodimer interface [polypeptide binding]; other site 511051003581 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 511051003582 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 511051003583 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003584 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003585 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 511051003586 Mg++ binding site [ion binding]; other site 511051003587 putative catalytic motif [active] 511051003588 putative substrate binding site [chemical binding]; other site 511051003589 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 511051003590 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511051003591 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003592 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003593 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 511051003594 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511051003595 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003596 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003597 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 511051003598 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511051003599 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511051003600 Septum formation initiator; Region: DivIC; cl17659 511051003601 MraW methylase family; Region: Methyltransf_5; cl17771 511051003602 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 511051003603 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 511051003604 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 511051003605 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 511051003606 GTP binding site; other site 511051003607 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 511051003608 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 511051003609 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 511051003610 catalytic loop [active] 511051003611 iron binding site [ion binding]; other site 511051003612 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 511051003613 4Fe-4S binding domain; Region: Fer4_6; pfam12837 511051003614 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 511051003615 [4Fe-4S] binding site [ion binding]; other site 511051003616 molybdopterin cofactor binding site; other site 511051003617 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 511051003618 molybdopterin cofactor binding site; other site 511051003619 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 511051003620 dimer interface [polypeptide binding]; other site 511051003621 [2Fe-2S] cluster binding site [ion binding]; other site 511051003622 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 511051003623 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 511051003624 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 511051003625 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 511051003626 putative dimer interface [polypeptide binding]; other site 511051003627 [2Fe-2S] cluster binding site [ion binding]; other site 511051003628 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 511051003629 dimer interface [polypeptide binding]; other site 511051003630 [2Fe-2S] cluster binding site [ion binding]; other site 511051003631 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 511051003632 SLBB domain; Region: SLBB; pfam10531 511051003633 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 511051003634 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 511051003635 dimer interface [polypeptide binding]; other site 511051003636 [2Fe-2S] cluster binding site [ion binding]; other site 511051003637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511051003638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051003639 ATP binding site [chemical binding]; other site 511051003640 Mg2+ binding site [ion binding]; other site 511051003641 G-X-G motif; other site 511051003642 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 511051003643 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 511051003644 putative dimer interface [polypeptide binding]; other site 511051003645 [2Fe-2S] cluster binding site [ion binding]; other site 511051003646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511051003647 dimerization interface [polypeptide binding]; other site 511051003648 putative Zn2+ binding site [ion binding]; other site 511051003649 putative DNA binding site [nucleotide binding]; other site 511051003650 DRTGG domain; Region: DRTGG; pfam07085 511051003651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 511051003652 ATP binding site [chemical binding]; other site 511051003653 Mg2+ binding site [ion binding]; other site 511051003654 G-X-G motif; other site 511051003655 DRTGG domain; Region: DRTGG; pfam07085 511051003656 Putative Fe-S cluster; Region: FeS; cl17515 511051003657 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 511051003658 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 511051003659 FMN-binding domain; Region: FMN_bind; cl01081 511051003660 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 511051003661 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 511051003662 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 511051003663 SLBB domain; Region: SLBB; pfam10531 511051003664 Double zinc ribbon; Region: DZR; pfam12773 511051003665 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 511051003666 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 511051003667 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511051003668 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511051003669 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 511051003670 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511051003671 active site 511051003672 HIGH motif; other site 511051003673 nucleotide binding site [chemical binding]; other site 511051003674 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511051003675 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 511051003676 active site 511051003677 KMSKS motif; other site 511051003678 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 511051003679 tRNA binding surface [nucleotide binding]; other site 511051003680 anticodon binding site; other site 511051003681 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 511051003682 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 511051003683 trimer interface [polypeptide binding]; other site 511051003684 putative Zn binding site [ion binding]; other site 511051003685 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 511051003686 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511051003687 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511051003688 RNA binding surface [nucleotide binding]; other site 511051003689 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511051003690 active site 511051003691 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 511051003692 SmpB-tmRNA interface; other site 511051003693 Bacterial SH3 domain homologues; Region: SH3b; smart00287 511051003694 Bacterial SH3 domain homologues; Region: SH3b; smart00287 511051003695 Bacterial SH3 domain; Region: SH3_3; pfam08239 511051003696 Bacterial SH3 domain; Region: SH3_3; pfam08239 511051003697 AMIN domain; Region: AMIN; pfam11741 511051003698 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 511051003699 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 511051003700 active site 511051003701 metal binding site [ion binding]; metal-binding site 511051003702 glutamate racemase; Provisional; Region: PRK00865 511051003703 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 511051003704 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 511051003705 putative NAD(P) binding site [chemical binding]; other site 511051003706 putative substrate binding site [chemical binding]; other site 511051003707 catalytic Zn binding site [ion binding]; other site 511051003708 structural Zn binding site [ion binding]; other site 511051003709 UGMP family protein; Validated; Region: PRK09604 511051003710 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 511051003711 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 511051003712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511051003713 Coenzyme A binding pocket [chemical binding]; other site 511051003714 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 511051003715 Glycoprotease family; Region: Peptidase_M22; pfam00814 511051003716 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 511051003717 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 511051003718 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 511051003719 oligomerisation interface [polypeptide binding]; other site 511051003720 mobile loop; other site 511051003721 roof hairpin; other site 511051003722 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 511051003723 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 511051003724 ring oligomerisation interface [polypeptide binding]; other site 511051003725 ATP/Mg binding site [chemical binding]; other site 511051003726 stacking interactions; other site 511051003727 hinge regions; other site 511051003728 Integrase core domain; Region: rve; pfam00665 511051003729 Helix-turn-helix domain; Region: HTH_28; pfam13518 511051003730 Winged helix-turn helix; Region: HTH_29; pfam13551 511051003731 Homeodomain-like domain; Region: HTH_32; pfam13565 511051003732 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511051003733 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051003734 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051003735 DNA binding residues [nucleotide binding] 511051003736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511051003737 binding surface 511051003738 TPR motif; other site 511051003739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 511051003740 TPR motif; other site 511051003741 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 511051003742 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051003743 Zn2+ binding site [ion binding]; other site 511051003744 Mg2+ binding site [ion binding]; other site 511051003745 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 511051003746 RNA methyltransferase, RsmE family; Region: TIGR00046 511051003747 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511051003748 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511051003749 active site 511051003750 HIGH motif; other site 511051003751 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511051003752 active site 511051003753 KMSKS motif; other site 511051003754 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 511051003755 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 511051003756 Creatinine amidohydrolase; Region: Creatininase; pfam02633 511051003757 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 511051003758 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 511051003759 Ferritin-like domain; Region: Ferritin; pfam00210 511051003760 ferroxidase diiron center [ion binding]; other site 511051003761 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 511051003762 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 511051003763 non-heme iron binding site [ion binding]; other site 511051003764 dimer interface [polypeptide binding]; other site 511051003765 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 511051003766 non-heme iron binding site [ion binding]; other site 511051003767 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 511051003768 non-heme iron binding site [ion binding]; other site 511051003769 tetramer interface [polypeptide binding]; other site 511051003770 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 511051003771 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511051003772 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 511051003773 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 511051003774 homotrimer interaction site [polypeptide binding]; other site 511051003775 zinc binding site [ion binding]; other site 511051003776 CDP-binding sites; other site 511051003777 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 511051003778 substrate binding site; other site 511051003779 dimer interface; other site 511051003780 DNA repair protein RadA; Provisional; Region: PRK11823 511051003781 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 511051003782 Walker A motif; other site 511051003783 ATP binding site [chemical binding]; other site 511051003784 Walker B motif; other site 511051003785 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 511051003786 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 511051003787 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 511051003788 dimer interface [polypeptide binding]; other site 511051003789 putative anticodon binding site; other site 511051003790 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 511051003791 motif 1; other site 511051003792 active site 511051003793 motif 2; other site 511051003794 motif 3; other site 511051003795 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 511051003796 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511051003797 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511051003798 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 511051003799 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 511051003800 FMN binding site [chemical binding]; other site 511051003801 active site 511051003802 catalytic residues [active] 511051003803 substrate binding site [chemical binding]; other site 511051003804 Type III pantothenate kinase; Region: Pan_kinase; cl17198 511051003805 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 511051003806 intersubunit interface [polypeptide binding]; other site 511051003807 active site 511051003808 Zn2+ binding site [ion binding]; other site 511051003809 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051003810 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 511051003811 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 511051003812 oligomer interface [polypeptide binding]; other site 511051003813 putative active site [active] 511051003814 metal binding site [ion binding]; metal-binding site 511051003815 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051003816 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 511051003817 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 511051003818 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 511051003819 G1 box; other site 511051003820 GTP/Mg2+ binding site [chemical binding]; other site 511051003821 G2 box; other site 511051003822 Switch I region; other site 511051003823 G3 box; other site 511051003824 Switch II region; other site 511051003825 G4 box; other site 511051003826 G5 box; other site 511051003827 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 511051003828 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 511051003829 ATP-binding site [chemical binding]; other site 511051003830 Sugar specificity; other site 511051003831 Pyrimidine base specificity; other site 511051003832 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051003833 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051003834 PLD-like domain; Region: PLDc_2; pfam13091 511051003835 putative active site [active] 511051003836 catalytic site [active] 511051003837 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051003838 PLD-like domain; Region: PLDc_2; pfam13091 511051003839 putative active site [active] 511051003840 catalytic site [active] 511051003841 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 511051003842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003843 dimer interface [polypeptide binding]; other site 511051003844 conserved gate region; other site 511051003845 putative PBP binding loops; other site 511051003846 ABC-ATPase subunit interface; other site 511051003847 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511051003848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051003849 dimer interface [polypeptide binding]; other site 511051003850 conserved gate region; other site 511051003851 putative PBP binding loops; other site 511051003852 ABC-ATPase subunit interface; other site 511051003853 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051003854 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511051003855 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 511051003856 conserved hypothetical protein; Region: MG423; TIGR00649 511051003857 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511051003858 Radical SAM superfamily; Region: Radical_SAM; pfam04055 511051003859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051003860 FeS/SAM binding site; other site 511051003861 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 511051003862 Glucose inhibited division protein A; Region: GIDA; pfam01134 511051003863 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 511051003864 DNA protecting protein DprA; Region: dprA; TIGR00732 511051003865 Predicted membrane protein [Function unknown]; Region: COG3601 511051003866 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 511051003867 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 511051003868 23S rRNA binding site [nucleotide binding]; other site 511051003869 L21 binding site [polypeptide binding]; other site 511051003870 L13 binding site [polypeptide binding]; other site 511051003871 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 511051003872 translation initiation factor IF-3; Region: infC; TIGR00168 511051003873 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 511051003874 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 511051003875 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 511051003876 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 511051003877 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 511051003878 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 511051003879 active site 511051003880 dimer interface [polypeptide binding]; other site 511051003881 motif 1; other site 511051003882 motif 2; other site 511051003883 motif 3; other site 511051003884 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 511051003885 anticodon binding site; other site 511051003886 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 511051003887 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 511051003888 DNA topoisomerase III; Validated; Region: PRK08173 511051003889 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 511051003890 active site 511051003891 putative interdomain interaction site [polypeptide binding]; other site 511051003892 putative metal-binding site [ion binding]; other site 511051003893 putative nucleotide binding site [chemical binding]; other site 511051003894 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511051003895 domain I; other site 511051003896 DNA binding groove [nucleotide binding] 511051003897 phosphate binding site [ion binding]; other site 511051003898 domain II; other site 511051003899 domain III; other site 511051003900 nucleotide binding site [chemical binding]; other site 511051003901 catalytic site [active] 511051003902 domain IV; other site 511051003903 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 511051003904 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 511051003905 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 511051003906 DNA-binding site [nucleotide binding]; DNA binding site 511051003907 RNA-binding motif; other site 511051003908 recombination factor protein RarA; Reviewed; Region: PRK13342 511051003909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511051003910 Walker A motif; other site 511051003911 ATP binding site [chemical binding]; other site 511051003912 Walker B motif; other site 511051003913 arginine finger; other site 511051003914 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 511051003915 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 511051003916 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 511051003917 active site 511051003918 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 511051003919 S-layer homology domain; Region: SLH; pfam00395 511051003920 S-layer homology domain; Region: SLH; pfam00395 511051003921 S-layer homology domain; Region: SLH; pfam00395 511051003922 metal-dependent hydrolase; Provisional; Region: PRK00685 511051003923 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 511051003924 NAD-dependent deacetylase; Provisional; Region: PRK00481 511051003925 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 511051003926 NAD+ binding site [chemical binding]; other site 511051003927 substrate binding site [chemical binding]; other site 511051003928 Zn binding site [ion binding]; other site 511051003929 Tetratricopeptide repeat; Region: TPR_12; pfam13424 511051003930 Tetratricopeptide repeat; Region: TPR_12; pfam13424 511051003931 KIF-1 binding protein C terminal; Region: KBP_C; pfam12309 511051003932 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 511051003933 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 511051003934 Walker A/P-loop; other site 511051003935 ATP binding site [chemical binding]; other site 511051003936 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 511051003937 ABC transporter signature motif; other site 511051003938 Walker B; other site 511051003939 D-loop; other site 511051003940 H-loop/switch region; other site 511051003941 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 511051003942 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 511051003943 Potassium binding sites [ion binding]; other site 511051003944 Cesium cation binding sites [ion binding]; other site 511051003945 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 511051003946 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 511051003947 iron-sulfur cluster [ion binding]; other site 511051003948 [2Fe-2S] cluster binding site [ion binding]; other site 511051003949 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 511051003950 hydrophobic ligand binding site; other site 511051003951 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511051003952 endonuclease III; Region: ENDO3c; smart00478 511051003953 minor groove reading motif; other site 511051003954 helix-hairpin-helix signature motif; other site 511051003955 substrate binding pocket [chemical binding]; other site 511051003956 active site 511051003957 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 511051003958 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 511051003959 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 511051003960 active site 511051003961 PHP Thumb interface [polypeptide binding]; other site 511051003962 metal binding site [ion binding]; metal-binding site 511051003963 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 511051003964 generic binding surface II; other site 511051003965 generic binding surface I; other site 511051003966 short chain dehydrogenase; Provisional; Region: PRK08339 511051003967 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 511051003968 putative NAD(P) binding site [chemical binding]; other site 511051003969 putative active site [active] 511051003970 Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739 511051003971 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918 511051003972 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 511051003973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511051003974 catalytic residue [active] 511051003975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051003976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051003977 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 511051003978 EamA-like transporter family; Region: EamA; pfam00892 511051003979 EamA-like transporter family; Region: EamA; pfam00892 511051003980 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 511051003981 active site 511051003982 catalytic triad [active] 511051003983 Predicted methyltransferases [General function prediction only]; Region: COG0313 511051003984 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 511051003985 putative SAM binding site [chemical binding]; other site 511051003986 putative homodimer interface [polypeptide binding]; other site 511051003987 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511051003988 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 511051003989 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 511051003990 G1 box; other site 511051003991 putative GEF interaction site [polypeptide binding]; other site 511051003992 GTP/Mg2+ binding site [chemical binding]; other site 511051003993 Switch I region; other site 511051003994 G2 box; other site 511051003995 G3 box; other site 511051003996 Switch II region; other site 511051003997 G4 box; other site 511051003998 G5 box; other site 511051003999 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 511051004000 Translation-initiation factor 2; Region: IF-2; pfam11987 511051004001 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 511051004002 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 511051004003 NusA N-terminal domain; Region: NusA_N; pfam08529 511051004004 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 511051004005 RNA binding site [nucleotide binding]; other site 511051004006 homodimer interface [polypeptide binding]; other site 511051004007 NusA-like KH domain; Region: KH_5; pfam13184 511051004008 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 511051004009 G-X-X-G motif; other site 511051004010 ribosome maturation protein RimP; Reviewed; Region: PRK00092 511051004011 Sm and related proteins; Region: Sm_like; cl00259 511051004012 heptamer interface [polypeptide binding]; other site 511051004013 Sm1 motif; other site 511051004014 hexamer interface [polypeptide binding]; other site 511051004015 RNA binding site [nucleotide binding]; other site 511051004016 Sm2 motif; other site 511051004017 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 511051004018 trimer interface [polypeptide binding]; other site 511051004019 active site 511051004020 EDD domain protein, DegV family; Region: DegV; TIGR00762 511051004021 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511051004022 EDD domain protein, DegV family; Region: DegV; TIGR00762 511051004023 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511051004024 Esterase/lipase [General function prediction only]; Region: COG1647 511051004025 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 511051004026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051004027 S-adenosylmethionine binding site [chemical binding]; other site 511051004028 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 511051004029 active site 511051004030 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 511051004031 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511051004032 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511051004033 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 511051004034 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 511051004035 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 511051004036 Walker A motif; other site 511051004037 ATP binding site [chemical binding]; other site 511051004038 Walker B motif; other site 511051004039 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 511051004040 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 511051004041 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 511051004042 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 511051004043 putative active site [active] 511051004044 catalytic residue [active] 511051004045 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 511051004046 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 511051004047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051004048 ATP binding site [chemical binding]; other site 511051004049 putative Mg++ binding site [ion binding]; other site 511051004050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051004051 nucleotide binding region [chemical binding]; other site 511051004052 ATP-binding site [chemical binding]; other site 511051004053 TRCF domain; Region: TRCF; pfam03461 511051004054 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 511051004055 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 511051004056 homodimer interface [polypeptide binding]; other site 511051004057 metal binding site [ion binding]; metal-binding site 511051004058 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 511051004059 homodimer interface [polypeptide binding]; other site 511051004060 active site 511051004061 putative chemical substrate binding site [chemical binding]; other site 511051004062 metal binding site [ion binding]; metal-binding site 511051004063 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 511051004064 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 511051004065 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051004066 active site 511051004067 metal binding site [ion binding]; metal-binding site 511051004068 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 511051004069 active site 511051004070 dimerization interface [polypeptide binding]; other site 511051004071 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 511051004072 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 511051004073 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 511051004074 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 511051004075 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 511051004076 putative ligand binding site [chemical binding]; other site 511051004077 NAD binding site [chemical binding]; other site 511051004078 dimer interface [polypeptide binding]; other site 511051004079 putative catalytic site [active] 511051004080 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 511051004081 putative active site; other site 511051004082 putative metal binding residues [ion binding]; other site 511051004083 signature motif; other site 511051004084 putative triphosphate binding site [ion binding]; other site 511051004085 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 511051004086 pyrroline-5-carboxylate reductase; Region: PLN02688 511051004087 glutamate formiminotransferase; Region: FtcD; TIGR02024 511051004088 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 511051004089 Formiminotransferase domain; Region: FTCD; pfam02971 511051004090 imidazolonepropionase; Validated; Region: PRK09356 511051004091 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 511051004092 active site 511051004093 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 511051004094 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 511051004095 aspartate aminotransferase; Provisional; Region: PRK05764 511051004096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511051004097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051004098 homodimer interface [polypeptide binding]; other site 511051004099 catalytic residue [active] 511051004100 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 511051004101 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 511051004102 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 511051004103 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 511051004104 active site 511051004105 nucleophile elbow; other site 511051004106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051004107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051004108 putative substrate translocation pore; other site 511051004109 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 511051004110 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 511051004111 active site 511051004112 HIGH motif; other site 511051004113 dimer interface [polypeptide binding]; other site 511051004114 KMSKS motif; other site 511051004115 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511051004116 RNA binding surface [nucleotide binding]; other site 511051004117 ferric uptake regulator; Provisional; Region: fur; PRK09462 511051004118 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 511051004119 metal binding site 2 [ion binding]; metal-binding site 511051004120 putative DNA binding helix; other site 511051004121 metal binding site 1 [ion binding]; metal-binding site 511051004122 dimer interface [polypeptide binding]; other site 511051004123 structural Zn2+ binding site [ion binding]; other site 511051004124 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 511051004125 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511051004126 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511051004127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051004128 dimer interface [polypeptide binding]; other site 511051004129 conserved gate region; other site 511051004130 putative PBP binding loops; other site 511051004131 ABC-ATPase subunit interface; other site 511051004132 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511051004133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051004134 Walker A/P-loop; other site 511051004135 ATP binding site [chemical binding]; other site 511051004136 Q-loop/lid; other site 511051004137 ABC transporter signature motif; other site 511051004138 Walker B; other site 511051004139 D-loop; other site 511051004140 H-loop/switch region; other site 511051004141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051004142 dimer interface [polypeptide binding]; other site 511051004143 conserved gate region; other site 511051004144 putative PBP binding loops; other site 511051004145 ABC-ATPase subunit interface; other site 511051004146 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511051004147 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511051004148 substrate binding pocket [chemical binding]; other site 511051004149 membrane-bound complex binding site; other site 511051004150 hinge residues; other site 511051004151 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 511051004152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511051004153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511051004154 DNA binding residues [nucleotide binding] 511051004155 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511051004156 Sporulation and spore germination; Region: Germane; pfam10646 511051004157 Sporulation and spore germination; Region: Germane; pfam10646 511051004158 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 511051004159 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511051004160 active site 511051004161 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 511051004162 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 511051004163 Walker A motif; other site 511051004164 ATP binding site [chemical binding]; other site 511051004165 Walker B motif; other site 511051004166 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 511051004167 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 511051004168 MPT binding site; other site 511051004169 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 511051004170 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511051004171 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511051004172 photolyase PhrII; Region: phr2; TIGR00591 511051004173 DNA photolyase; Region: DNA_photolyase; pfam00875 511051004174 Protein of unknown function (DUF523); Region: DUF523; pfam04463 511051004175 Uncharacterized conserved protein [Function unknown]; Region: COG3272 511051004176 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 511051004177 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 511051004178 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 511051004179 active site 511051004180 (T/H)XGH motif; other site 511051004181 GTPase CgtA; Reviewed; Region: obgE; PRK12297 511051004182 GTP1/OBG; Region: GTP1_OBG; pfam01018 511051004183 Obg GTPase; Region: Obg; cd01898 511051004184 G1 box; other site 511051004185 GTP/Mg2+ binding site [chemical binding]; other site 511051004186 Switch I region; other site 511051004187 G2 box; other site 511051004188 G3 box; other site 511051004189 Switch II region; other site 511051004190 G4 box; other site 511051004191 G5 box; other site 511051004192 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 511051004193 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 511051004194 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 511051004195 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 511051004196 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004197 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511051004198 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 511051004199 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 511051004200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051004201 dimer interface [polypeptide binding]; other site 511051004202 conserved gate region; other site 511051004203 putative PBP binding loops; other site 511051004204 ABC-ATPase subunit interface; other site 511051004205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051004206 putative PBP binding loops; other site 511051004207 ABC-ATPase subunit interface; other site 511051004208 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 511051004209 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 511051004210 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 511051004211 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 511051004212 Metal-binding active site; metal-binding site 511051004213 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511051004214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051004215 Walker A/P-loop; other site 511051004216 ATP binding site [chemical binding]; other site 511051004217 Q-loop/lid; other site 511051004218 ABC transporter signature motif; other site 511051004219 Walker B; other site 511051004220 D-loop; other site 511051004221 H-loop/switch region; other site 511051004222 TOBE domain; Region: TOBE_2; pfam08402 511051004223 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 511051004224 classical (c) SDRs; Region: SDR_c; cd05233 511051004225 NAD(P) binding site [chemical binding]; other site 511051004226 active site 511051004227 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511051004228 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 511051004229 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511051004230 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 511051004231 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 511051004232 active site 511051004233 dimerization interface [polypeptide binding]; other site 511051004234 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 511051004235 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 511051004236 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 511051004237 active site 511051004238 metal binding site [ion binding]; metal-binding site 511051004239 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 511051004240 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 511051004241 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 511051004242 N- and C-terminal domain interface [polypeptide binding]; other site 511051004243 putative active site [active] 511051004244 MgATP binding site [chemical binding]; other site 511051004245 catalytic site [active] 511051004246 metal binding site [ion binding]; metal-binding site 511051004247 putative xylulose binding site [chemical binding]; other site 511051004248 putative homodimer interface [polypeptide binding]; other site 511051004249 BtpA family; Region: BtpA; cl00440 511051004250 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 511051004251 Phosphoenolpyruvate carboxylase; Region: PEPcase_2; pfam14010 511051004252 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511051004253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051004254 Walker A/P-loop; other site 511051004255 ATP binding site [chemical binding]; other site 511051004256 Q-loop/lid; other site 511051004257 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511051004258 ABC transporter; Region: ABC_tran_2; pfam12848 511051004259 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511051004260 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 511051004261 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 511051004262 trimer interface [polypeptide binding]; other site 511051004263 active site 511051004264 substrate binding site [chemical binding]; other site 511051004265 CoA binding site [chemical binding]; other site 511051004266 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 511051004267 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 511051004268 dimer interface [polypeptide binding]; other site 511051004269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511051004270 catalytic residue [active] 511051004271 Sugar fermentation stimulation protein; Region: SfsA; cl00647 511051004272 Protein of unknown function DUF72; Region: DUF72; pfam01904 511051004273 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 511051004274 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 511051004275 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 511051004276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004277 FeS/SAM binding site; other site 511051004278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511051004279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511051004280 dimerization interface [polypeptide binding]; other site 511051004281 putative DNA binding site [nucleotide binding]; other site 511051004282 putative Zn2+ binding site [ion binding]; other site 511051004283 Protein of unknown function (DUF996); Region: DUF996; cl00970 511051004284 Protein of unknown function (DUF996); Region: DUF996; cl00970 511051004285 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 511051004286 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 511051004287 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 511051004288 Flavodoxin domain; Region: Flavodoxin_5; cl17428 511051004289 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 511051004290 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511051004291 Uncharacterized conserved protein [Function unknown]; Region: COG1615 511051004292 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 511051004293 Protein of unknown function (DUF505); Region: DUF505; pfam04458 511051004294 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051004295 Zn2+ binding site [ion binding]; other site 511051004296 Mg2+ binding site [ion binding]; other site 511051004297 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511051004298 amidase catalytic site [active] 511051004299 Zn binding residues [ion binding]; other site 511051004300 substrate binding site [chemical binding]; other site 511051004301 S-layer homology domain; Region: SLH; pfam00395 511051004302 YvrJ protein family; Region: YvrJ; pfam12841 511051004303 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 511051004304 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 511051004305 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 511051004306 substrate binding site [chemical binding]; other site 511051004307 dimer interface [polypeptide binding]; other site 511051004308 ATP binding site [chemical binding]; other site 511051004309 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 511051004310 active site 511051004311 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 511051004312 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 511051004313 ligand binding site [chemical binding]; other site 511051004314 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 511051004315 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511051004316 Walker A/P-loop; other site 511051004317 ATP binding site [chemical binding]; other site 511051004318 Q-loop/lid; other site 511051004319 ABC transporter signature motif; other site 511051004320 Walker B; other site 511051004321 D-loop; other site 511051004322 H-loop/switch region; other site 511051004323 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511051004324 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511051004325 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051004326 TM-ABC transporter signature motif; other site 511051004327 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511051004328 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051004329 TM-ABC transporter signature motif; other site 511051004330 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 511051004331 active site 511051004332 tetramer interface [polypeptide binding]; other site 511051004333 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 511051004334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511051004335 AAA domain; Region: AAA_12; pfam13087 511051004336 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 511051004337 six-cysteine peptide SCIFF; Region: six_Cys_in_45; TIGR03973 511051004338 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 511051004339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004340 FeS/SAM binding site; other site 511051004341 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 511051004342 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 511051004343 nucleotide binding site/active site [active] 511051004344 HIT family signature motif; other site 511051004345 catalytic residue [active] 511051004346 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 511051004347 Cl- selectivity filter; other site 511051004348 Cl- binding residues [ion binding]; other site 511051004349 pore gating glutamate residue; other site 511051004350 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 511051004351 dimer interface [polypeptide binding]; other site 511051004352 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 511051004353 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 511051004354 Predicted transcriptional regulators [Transcription]; Region: COG1695 511051004355 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 511051004356 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 511051004357 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511051004358 DXD motif; other site 511051004359 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 511051004360 4Fe-4S binding domain; Region: Fer4_5; pfam12801 511051004361 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 511051004362 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 511051004363 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 511051004364 dinuclear metal binding motif [ion binding]; other site 511051004365 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 511051004366 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511051004367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511051004368 non-specific DNA binding site [nucleotide binding]; other site 511051004369 salt bridge; other site 511051004370 sequence-specific DNA binding site [nucleotide binding]; other site 511051004371 Domain of unknown function (DUF955); Region: DUF955; cl01076 511051004372 CTP synthetase; Validated; Region: pyrG; PRK05380 511051004373 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 511051004374 Catalytic site [active] 511051004375 active site 511051004376 UTP binding site [chemical binding]; other site 511051004377 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 511051004378 active site 511051004379 putative oxyanion hole; other site 511051004380 catalytic triad [active] 511051004381 short chain dehydrogenase; Validated; Region: PRK06182 511051004382 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 511051004383 NADP binding site [chemical binding]; other site 511051004384 active site 511051004385 steroid binding site; other site 511051004386 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 511051004387 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 511051004388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 511051004389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511051004390 Predicted dehydrogenase [General function prediction only]; Region: COG0579 511051004391 hydroxyglutarate oxidase; Provisional; Region: PRK11728 511051004392 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 511051004393 glycerol kinase; Provisional; Region: glpK; PRK00047 511051004394 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 511051004395 N- and C-terminal domain interface [polypeptide binding]; other site 511051004396 active site 511051004397 MgATP binding site [chemical binding]; other site 511051004398 catalytic site [active] 511051004399 metal binding site [ion binding]; metal-binding site 511051004400 putative homotetramer interface [polypeptide binding]; other site 511051004401 glycerol binding site [chemical binding]; other site 511051004402 homodimer interface [polypeptide binding]; other site 511051004403 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511051004404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511051004405 Walker A/P-loop; other site 511051004406 ATP binding site [chemical binding]; other site 511051004407 Q-loop/lid; other site 511051004408 ABC transporter signature motif; other site 511051004409 Walker B; other site 511051004410 D-loop; other site 511051004411 H-loop/switch region; other site 511051004412 TOBE domain; Region: TOBE_2; pfam08402 511051004413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051004414 dimer interface [polypeptide binding]; other site 511051004415 conserved gate region; other site 511051004416 putative PBP binding loops; other site 511051004417 ABC-ATPase subunit interface; other site 511051004418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511051004419 dimer interface [polypeptide binding]; other site 511051004420 conserved gate region; other site 511051004421 ABC-ATPase subunit interface; other site 511051004422 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 511051004423 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 511051004424 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 511051004425 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 511051004426 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 511051004427 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 511051004428 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 511051004429 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 511051004430 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511051004431 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511051004432 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511051004433 dimerization domain swap beta strand [polypeptide binding]; other site 511051004434 regulatory protein interface [polypeptide binding]; other site 511051004435 active site 511051004436 regulatory phosphorylation site [posttranslational modification]; other site 511051004437 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 511051004438 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 511051004439 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 511051004440 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 511051004441 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 511051004442 active site 511051004443 P-loop; other site 511051004444 phosphorylation site [posttranslational modification] 511051004445 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511051004446 active site 511051004447 phosphorylation site [posttranslational modification] 511051004448 HTH domain; Region: HTH_11; pfam08279 511051004449 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 511051004450 HTH domain; Region: HTH_11; pfam08279 511051004451 PRD domain; Region: PRD; pfam00874 511051004452 PRD domain; Region: PRD; pfam00874 511051004453 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 511051004454 active site 511051004455 P-loop; other site 511051004456 phosphorylation site [posttranslational modification] 511051004457 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511051004458 active site 511051004459 phosphorylation site [posttranslational modification] 511051004460 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051004461 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 511051004462 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 511051004463 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 511051004464 DXD motif; other site 511051004465 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 511051004466 Predicted membrane protein [Function unknown]; Region: COG1288 511051004467 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 511051004468 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 511051004469 active site 511051004470 Zn binding site [ion binding]; other site 511051004471 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 511051004472 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 511051004473 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004474 FeS/SAM binding site; other site 511051004475 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 511051004476 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 511051004477 glutamate dehydrogenase; Provisional; Region: PRK09414 511051004478 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 511051004479 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 511051004480 NAD(P) binding site [chemical binding]; other site 511051004481 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 511051004482 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 511051004483 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 511051004484 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 511051004485 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 511051004486 G1 box; other site 511051004487 GTP/Mg2+ binding site [chemical binding]; other site 511051004488 Switch I region; other site 511051004489 G2 box; other site 511051004490 G3 box; other site 511051004491 Switch II region; other site 511051004492 G4 box; other site 511051004493 G5 box; other site 511051004494 Nucleoside recognition; Region: Gate; pfam07670 511051004495 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 511051004496 Nucleoside recognition; Region: Gate; pfam07670 511051004497 FeoA domain; Region: FeoA; pfam04023 511051004498 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 511051004499 Spherulation-specific family 4; Region: Spherulin4; pfam12138 511051004500 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 511051004501 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 511051004502 active site 511051004503 putative substrate binding pocket [chemical binding]; other site 511051004504 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 511051004505 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 511051004506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 511051004507 TPR motif; other site 511051004508 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 511051004509 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 511051004510 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 511051004511 Walker A motif; other site 511051004512 ATP binding site [chemical binding]; other site 511051004513 Walker B motif; other site 511051004514 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 511051004515 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 511051004516 Walker A motif; other site 511051004517 ATP binding site [chemical binding]; other site 511051004518 Walker B motif; other site 511051004519 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 511051004520 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511051004521 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511051004522 YcfA-like protein; Region: YcfA; pfam07927 511051004523 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 511051004524 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511051004525 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051004526 TM-ABC transporter signature motif; other site 511051004527 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511051004528 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511051004529 TM-ABC transporter signature motif; other site 511051004530 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 511051004531 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511051004532 Walker A/P-loop; other site 511051004533 ATP binding site [chemical binding]; other site 511051004534 Q-loop/lid; other site 511051004535 ABC transporter signature motif; other site 511051004536 Walker B; other site 511051004537 D-loop; other site 511051004538 H-loop/switch region; other site 511051004539 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511051004540 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 511051004541 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 511051004542 ligand binding site [chemical binding]; other site 511051004543 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 511051004544 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 511051004545 G1 box; other site 511051004546 GTP/Mg2+ binding site [chemical binding]; other site 511051004547 G2 box; other site 511051004548 Switch I region; other site 511051004549 G3 box; other site 511051004550 Switch II region; other site 511051004551 G4 box; other site 511051004552 G5 box; other site 511051004553 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 511051004554 6-phosphofructokinase; Provisional; Region: PRK03202 511051004555 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 511051004556 active site 511051004557 ADP/pyrophosphate binding site [chemical binding]; other site 511051004558 dimerization interface [polypeptide binding]; other site 511051004559 allosteric effector site; other site 511051004560 fructose-1,6-bisphosphate binding site; other site 511051004561 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 511051004562 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 511051004563 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 511051004564 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 511051004565 trmE is a tRNA modification GTPase; Region: trmE; cd04164 511051004566 G1 box; other site 511051004567 GTP/Mg2+ binding site [chemical binding]; other site 511051004568 Switch I region; other site 511051004569 G2 box; other site 511051004570 Switch II region; other site 511051004571 G3 box; other site 511051004572 G4 box; other site 511051004573 G5 box; other site 511051004574 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 511051004575 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 511051004576 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 511051004577 G-X-X-G motif; other site 511051004578 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 511051004579 RxxxH motif; other site 511051004580 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 511051004581 Haemolytic domain; Region: Haemolytic; pfam01809 511051004582 Ribonuclease P; Region: Ribonuclease_P; pfam00825 511051004583 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 511051004584 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 511051004585 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 511051004586 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 511051004587 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 511051004588 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511051004589 carboxyltransferase (CT) interaction site; other site 511051004590 biotinylation site [posttranslational modification]; other site 511051004591 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 511051004592 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511051004593 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511051004594 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 511051004595 active site 511051004596 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511051004597 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 511051004598 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 511051004599 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 511051004600 Substrate-binding site [chemical binding]; other site 511051004601 Substrate specificity [chemical binding]; other site 511051004602 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 511051004603 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 511051004604 active site 511051004605 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 511051004606 metal binding site [ion binding]; metal-binding site 511051004607 active site 511051004608 I-site; other site 511051004609 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 511051004610 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511051004611 DXD motif; other site 511051004612 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004613 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 511051004614 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004615 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004616 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511051004617 active site 511051004618 Uncharacterized conserved protein [Function unknown]; Region: COG2361 511051004619 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 511051004620 active site 511051004621 NTP binding site [chemical binding]; other site 511051004622 metal binding triad [ion binding]; metal-binding site 511051004623 antibiotic binding site [chemical binding]; other site 511051004624 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 511051004625 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 511051004626 Peptidase family M23; Region: Peptidase_M23; pfam01551 511051004627 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 511051004628 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004629 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004630 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004631 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 511051004632 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004633 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004634 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 511051004635 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 511051004636 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 511051004637 active site 511051004638 dimer interfaces [polypeptide binding]; other site 511051004639 catalytic residues [active] 511051004640 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051004641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 511051004642 Transposase; Region: DEDD_Tnp_IS110; pfam01548 511051004643 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 511051004644 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 511051004645 GIY-YIG motif/motif A; other site 511051004646 putative active site [active] 511051004647 putative metal binding site [ion binding]; other site 511051004648 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 511051004649 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511051004650 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 511051004651 putative active site [active] 511051004652 putative metal binding site [ion binding]; other site 511051004653 Predicted transcriptional regulators [Transcription]; Region: COG1695 511051004654 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 511051004655 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 511051004656 O-Antigen ligase; Region: Wzy_C; pfam04932 511051004657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511051004658 TPR motif; other site 511051004659 binding surface 511051004660 TPR repeat; Region: TPR_11; pfam13414 511051004661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511051004662 binding surface 511051004663 TPR motif; other site 511051004664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511051004665 binding surface 511051004666 TPR motif; other site 511051004667 Fibronectin type 3 domain; Region: FN3; smart00060 511051004668 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 511051004669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511051004670 NAD(P) binding site [chemical binding]; other site 511051004671 active site 511051004672 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 511051004673 active site 511051004674 NTP binding site [chemical binding]; other site 511051004675 metal binding triad [ion binding]; metal-binding site 511051004676 antibiotic binding site [chemical binding]; other site 511051004677 Protein of unknown function DUF86; Region: DUF86; cl01031 511051004678 Bacterial sugar transferase; Region: Bac_transf; pfam02397 511051004679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511051004680 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 511051004681 putative ADP-binding pocket [chemical binding]; other site 511051004682 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511051004683 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 511051004684 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 511051004685 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511051004686 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 511051004687 putative ADP-binding pocket [chemical binding]; other site 511051004688 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 511051004689 active site 511051004690 Integrase core domain; Region: rve; pfam00665 511051004691 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 511051004692 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 511051004693 active site 511051004694 catalytic residues [active] 511051004695 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 511051004696 PA/protease domain interface [polypeptide binding]; other site 511051004697 putative integrin binding motif; other site 511051004698 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 511051004699 catalytic residues [active] 511051004700 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 511051004701 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 511051004702 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 511051004703 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 511051004704 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004705 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004706 Bacterial Ig-like domain; Region: Big_5; pfam13205 511051004707 Bacterial Ig-like domain; Region: Big_5; pfam13205 511051004708 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 511051004709 generic binding surface I; other site 511051004710 generic binding surface II; other site 511051004711 Bacterial Ig-like domain; Region: Big_5; pfam13205 511051004712 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051004713 PLD-like domain; Region: PLDc_2; pfam13091 511051004714 putative active site [active] 511051004715 catalytic site [active] 511051004716 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 511051004717 PLD-like domain; Region: PLDc_2; pfam13091 511051004718 putative active site [active] 511051004719 catalytic site [active] 511051004720 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 511051004721 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004722 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004723 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 511051004724 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 511051004725 active site 511051004726 Zn binding site [ion binding]; other site 511051004727 EamA-like transporter family; Region: EamA; pfam00892 511051004728 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 511051004729 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 511051004730 MoaE interaction surface [polypeptide binding]; other site 511051004731 MoeB interaction surface [polypeptide binding]; other site 511051004732 thiocarboxylated glycine; other site 511051004733 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 511051004734 active site 511051004735 Uncharacterized conserved protein [Function unknown]; Region: COG3391 511051004736 NHL repeat; Region: NHL; pfam01436 511051004737 NHL repeat; Region: NHL; pfam01436 511051004738 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 511051004739 NHL repeat; Region: NHL; pfam01436 511051004740 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 511051004741 dockerin binding interface; other site 511051004742 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004743 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 511051004744 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 511051004745 putative active site [active] 511051004746 catalytic triad [active] 511051004747 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 511051004748 PA/protease domain interface [polypeptide binding]; other site 511051004749 putative integrin binding motif; other site 511051004750 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 511051004751 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 511051004752 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 511051004753 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 511051004754 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 511051004755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511051004756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511051004757 Esterase/lipase [General function prediction only]; Region: COG1647 511051004758 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 511051004759 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 511051004760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051004761 active site 511051004762 phosphorylation site [posttranslational modification] 511051004763 intermolecular recognition site; other site 511051004764 dimerization interface [polypeptide binding]; other site 511051004765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051004766 Zn2+ binding site [ion binding]; other site 511051004767 Mg2+ binding site [ion binding]; other site 511051004768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 511051004769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511051004770 dimer interface [polypeptide binding]; other site 511051004771 phosphorylation site [posttranslational modification] 511051004772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511051004773 ATP binding site [chemical binding]; other site 511051004774 Mg2+ binding site [ion binding]; other site 511051004775 G-X-G motif; other site 511051004776 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 511051004777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511051004778 active site 511051004779 phosphorylation site [posttranslational modification] 511051004780 intermolecular recognition site; other site 511051004781 peroxiredoxin; Provisional; Region: PRK13189 511051004782 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 511051004783 dimer interface [polypeptide binding]; other site 511051004784 decamer (pentamer of dimers) interface [polypeptide binding]; other site 511051004785 catalytic triad [active] 511051004786 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 511051004787 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 511051004788 reverse gyrase; Reviewed; Region: PRK09401 511051004789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511051004790 ATP binding site [chemical binding]; other site 511051004791 putative Mg++ binding site [ion binding]; other site 511051004792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511051004793 nucleotide binding region [chemical binding]; other site 511051004794 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 511051004795 active site 511051004796 metal binding site [ion binding]; metal-binding site 511051004797 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511051004798 domain I; other site 511051004799 DNA binding groove [nucleotide binding] 511051004800 phosphate binding site [ion binding]; other site 511051004801 domain II; other site 511051004802 domain III; other site 511051004803 nucleotide binding site [chemical binding]; other site 511051004804 catalytic site [active] 511051004805 domain IV; other site 511051004806 Methyltransferase domain; Region: Methyltransf_23; pfam13489 511051004807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511051004808 S-adenosylmethionine binding site [chemical binding]; other site 511051004809 YKOF-related Family; Region: Ykof; pfam07615 511051004810 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 511051004811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004812 FeS/SAM binding site; other site 511051004813 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 511051004814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004815 FeS/SAM binding site; other site 511051004816 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 511051004817 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 511051004818 AAA domain; Region: AAA_14; pfam13173 511051004819 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 511051004820 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511051004821 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511051004822 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 511051004823 Predicted transcriptional regulators [Transcription]; Region: COG1695 511051004824 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 511051004825 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 511051004826 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511051004827 active site 511051004828 metal binding site [ion binding]; metal-binding site 511051004829 homotetramer interface [polypeptide binding]; other site 511051004830 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 511051004831 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511051004832 P-loop; other site 511051004833 Magnesium ion binding site [ion binding]; other site 511051004834 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 511051004835 Magnesium ion binding site [ion binding]; other site 511051004836 ParB-like nuclease domain; Region: ParB; smart00470 511051004837 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 511051004838 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 511051004839 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 511051004840 Moco binding site; other site 511051004841 metal coordination site [ion binding]; other site 511051004842 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 511051004843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511051004844 FeS/SAM binding site; other site 511051004845 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 511051004846 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511051004847 Zn2+ binding site [ion binding]; other site 511051004848 Mg2+ binding site [ion binding]; other site 511051004849 Transposase [DNA replication, recombination, and repair]; Region: COG5421 511051004850 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 511051004851 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511051004852 FtsX-like permease family; Region: FtsX; pfam02687 511051004853 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511051004854 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511051004855 Walker A/P-loop; other site 511051004856 ATP binding site [chemical binding]; other site 511051004857 Q-loop/lid; other site 511051004858 ABC transporter signature motif; other site 511051004859 Walker B; other site 511051004860 D-loop; other site 511051004861 H-loop/switch region; other site 511051004862 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 511051004863 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 511051004864 HlyD family secretion protein; Region: HlyD_3; pfam13437 511051004865 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11866 511051004866 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 511051004867 TPP-binding site [chemical binding]; other site 511051004868 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 511051004869 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 511051004870 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 511051004871 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 511051004872 dimer interface [polypeptide binding]; other site 511051004873 PYR/PP interface [polypeptide binding]; other site 511051004874 TPP binding site [chemical binding]; other site 511051004875 substrate binding site [chemical binding]; other site 511051004876 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 511051004877 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 511051004878 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 511051004879 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 511051004880 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 511051004881 DNA binding residues [nucleotide binding] 511051004882 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 511051004883 catalytic residues [active] 511051004884 catalytic nucleophile [active]